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Comment by Dr. Krishna Kumari Challa on July 29, 2016 at 7:35am

Open-source drug discovery a success
Researchers from around the world collaborate
In what is being called the first-ever test of open-source drug-discovery, researchers from around the world have successfully identified compounds to pursue in treating and preventing parasite-borne illnesses such as malaria as well as cancer.

Starting in late 2011, the Medicines for Malaria Venture, based in Geneva, Switzerland, distributed 400 diverse compounds with antimalarial activity free of charge to 200 labs in 30 countries. One-third of the labs reported their results in a paper published today in PLOS Pathogens, "Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond."

The results have ignited more a dozen drug-development projects for a variety of diseases.

"The trial was successful not only in identifying compounds to pursue for anti-malarials, but it also identified compounds to treat other parasites and cancer," said lead author Wesley Van Voorhis. To help lead the project, Van Voorhis took a sabbatical from his roles as a University of Washington professor of medicine (allergy and infectious diseases) and director of the Center for Emerging and Re-emerging Infectious Diseases.

The National Cancer Institute is now working on a colon cancer drug that emerged from the testing, Van Voorhis said. Several European labs are working on anti-worm compounds, and numerous U.S. labs are investigating drugs to combat other parasites. Medicines for Malaria Venture is also working with pharmaceutical companies GSK and Novartis on related anti-malarials, he added.

In their paper, researchers cited the lack of interaction between academia and industry as a major curb to innovation in drug discovery.
Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open-source drug discovery, with sharing of information, is clearly a first step towards overcoming that gap," they wrote.

The Malaria Box distributed 400 diverse druglike molecules that were most often found in industry collections, helping to bridge the gap between industry and academia.

This open-access effort was so successful that Medicines for Malaria Venture has begun to distribute another set of compounds with broader potential applicability, called the Pathogen Box. The box is available now to scientific labs globally.
Source: UNIVERSITY OF WASHINGTON HEALTH SCIENCES/UW MEDICINE

Comment by Dr. Krishna Kumari Challa on July 27, 2016 at 8:10am

Researchers in China and the UK have attempted to define and measure human intelligence and discover how intellect works. The research team, which includes researchers from Fudan University, quantified the brain’s dynamic functions and identified how different parts of the brain interact with each other at different times. The work was published in Brain. Using resting-state magnetic resonance imaging analysis on thousands of people’s brains around the world, the research has found that the areas of the brain that are associated with learning and development show high levels of variability, meaning that they change their neural connections with other parts of the brain more frequently—over a matter of minutes or seconds. On the other hand, regions of the brain that aren’t associated with intelligence—the visual, auditory, and sensory-motor areas—show small variability and adaptability. What the researchers found was that the more variable a brain is, and the more its different parts frequently connect with each other, the higher a person’s IQ and creativity are.
http://brain.oxfordjournals.org/content/139/8/2307

Comment by Dr. Krishna Kumari Challa on July 23, 2016 at 9:45am

How bees cool their homes...
When a honeybee colony gets hot and bothered, the crisis sets tongues wagging. Middle-aged bees stick their tongues into the mouths of their elders, launching these special drinker bees to go collect water. That’s just one detail uncovered during a new study of how a colony superorganism cools in hot weather.
Honeybees communicate about collecting water and work together in deploying it as air-conditioning. The tests show just how important water is for protecting a colony from overheating.
Bees often get as much water as they need in the nectar they sip. But they do need extra water at times, such as during overheating in the center of the nest where eggs and young are coddled. When researchers artificially heated that zone in two colonies confined in a greenhouse, worker bees fought back. They used their wings to fan hot air out of the hive. “You can put your hand in the opening of a hive on a hot day and feel the blast of air that’s being pushed out.
Several hundred bees also move out of the nest to cluster in a beardlike mass nearby. Their evacuation reduces body heat within the nest and opens up passageways for greater airflow.
The bees also had a Plan C — evaporative cooling. Middle-aged bees inside a hive walked toward the nest entrance to where a small number of elderly bees, less than 1 percent of the colony, hang out and wait until water is needed.
http://jeb.biologists.org/content/219/14/2156.abstract

Comment by Dr. Krishna Kumari Challa on July 23, 2016 at 9:03am

A family of related, exotic particles, each made up of four quarks, has been discovered. The finding could hold clues about the evolution of the universe, the researchers said.

The four newfound tetraquarks, now called X(4140), X(4274), X(4500) and X(4700), each are composed of two quarks and two antiquarks (the antimatter partners of quarks). Yet each of the newfound particles has a different mass and different subatomic properties. They are considered a family of tetraquark siblings because of having the same quark composition and arrangement.

Quarks are elementary particles, the building blocks of protons and neutrons. Until the recent discoveries of tetra and even pentaquarks, physicists thought quarks grouped only into pairs or triplets. The newfound tetraquark family is even more distinct because the family members are made up of heavy, exotic types of quarks — known as charm quarks and strange quarks — which are not found in everyday materials.
Skwarnicki and Britton detailed their discoveries in the June issue of the journal Physical Review Letters.

http://arxiv.org/abs/1606.07898

Comment by Dr. Krishna Kumari Challa on July 21, 2016 at 9:44am

Scientists explain Why the turtle got its shell
Burrowing power, not protection may have triggered carapace evolution
Turtle shells didn’t get their start as natural armor, it seems. The reptiles’ ancestors might have evolved partial shells to help them burrow instead, new research suggests. Only later did the hard body covering become useful for protection.

The findings might also help explain how turtles’ ancestors survived a mass extinction 250 million years ago that wiped out most plants and animals on earth, scientists report online July 14 in Current Biology.

Most shelled animals, like armadillos, get their shells by adding bony scales all over their bodies. Turtles, though, form shells by gradually broadening their ribs until the bones fuse together. Fossils from ancient reptiles with partial shells made from thickened ribs suggest that turtles’ ancestors began to suit up in the same way.

It’s an unusual mechanism, says Tyler Lyson, a paleontologist at the Denver Museum of Nature and Science who led the study. Thicker ribs don’t offer much in the way of protection until they’re fully fused, as they are in modern turtles. And the modification makes critical functions like moving and breathing much harder — a steep price for an animal to pay. So Lyson suspected there was some advantage other than protection to the partial shells.

It’s a very plausible idea, although many other animals burrow but don’t have these specializations.

T. Lyson et al. Fossorial origin of the turtle shell. Current Biology. Vol. 26, July 25, 2016, p. 1. doi: 10.1016/j.cub.2016.05.020.

Comment by Dr. Krishna Kumari Challa on July 21, 2016 at 8:34am

A research project led by The Australian National University (ANU) has closed an important gap in the understanding of a fundamental process of life -- the creation of proteins based on recipes called RNA.

RNAs are short-lived copies of genetic information stored in DNA. They are read by cellular ribosomes, which translate the recipes into proteins to become the main building blocks of life.

Lead researcher Professor Thomas Preiss from The John Curtin School of Medical Research (JCSMR) at ANU, said the new understanding would open up avenues for treatment of a wide range of diseases including cancer, heart disease and a spectrum of rarer genetic diseases.
The research team took snapshots of how ribosomes distribute along the RNA strings, paying particular attention to how ribosomes make sure they read the recipe from the correct starting point.

Cells throughout the body contain the same complete blueprint for life in their DNA.

"To create and maintain cells as diverse as those in the brain, bone or liver requires great precision in terms of which RNA recipes are made available, where and when.
How efficiently and accurately ribosomes read and translate the recipes is also critical.

For example, ribosomes are known to become over-active in cancer.
The research confirms a 40-year-old theory that explains how the ribosome correctly picks up the beginning of the code, even though the code usually only begins some distance inside the RNA string.
Research team member Dr Nikolay Shirokikh from ANU said the project examined where the two components of the ribosome started to attach to RNA strings.

"The theory was that the smaller half of the ribosome attaches itself to the very beginning of the RNA and then scans along the string until it finds the start signal of the recipe. There, the larger half joins and the whole ribosome begins to manufacture a protein," Dr Shirokikh said.

"Our ribosome snapshot approach has finally provided proof that the scanning model is correct. We also gained new insight into how fast the ribosome can complete the different tasks and how other cellular components come in to help it along."
The ribosome snapshot data generated with the new technique was made available to scientists globally via an app for high-content data visualisation developed at the Monash Bioinformatics Platform.
The research has been published in the journal Nature.
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18647...

Comment by Dr. Krishna Kumari Challa on July 17, 2016 at 10:51am

Species Biodiversity has fallen below 'safe' level on majority of land on Earth, a recent study reported in Science  says. 

Each year humans use more land for buildings, roads, industries and agriculture purposes. That may not always cause extinctions, it does reduce the number of species within specific ecosystems. When bio-diversity drops too low ecosystems can loose their resilience and even stop functioning.

 In many parts of the world, we are approaching a situation where human intervention might be needed to sustain ecosystem function, according to the study. 

Biodiversity intactness within most biomes (especially grassland biomes), most biodiversity hotspots, and even some wilderness areas is inferred to be beyond the boundary. Such widespread transgression of safe limits suggests that biodiversity loss, if unchecked, will undermine efforts toward long-term sustainable development.

The greatest changes have happened in those places where most people live, which might affect physical and psychological wellbeing. To address this, we will have to preserve the remaining areas of natural vegetation and restore human-used lands

http://science.sciencemag.org/content/353/6296/288

Comment by Dr. Krishna Kumari Challa on July 16, 2016 at 8:16am

Bright light accelerates ageing in mice

Exposure to artificial light weakens rodent’ muscles and bones, but risks to humans are not clear 

Lucassen and Johanna Meijer, a neuroscientist at Leiden, report  in Current Biology that a constant barrage of bright light prematurely ages mice, playing havoc with their circadian clocksand causing a cascade of health problems.

Mice exposed to constant light experienced bone-density loss, skeletal-muscle weakness and inflammation; restoring their health was as simple as turning the lights off. The findings are preliminary, but they suggest that people living in cities flooded with artificial light may face similar health risks.

Many previous studies have hinted at a connection between artificial light exposure and health problems in animals and people. Epidemiological analyses have found that shift workers have an increased risk of breast cancer, metabolic syndrom and osteoporosis. People exposed to bright light at night are more likely to have cardiovascular disease and often don’t get enough sleep.

And disruption of the biological clock alone might not cause the health effects reported in the study, says Steven Lockley, a neuroscientist at Harvard Medical School in Boston, Massachusetts. Poor sleep and light itself can each affect health, so an altered circadian clock may not be to blame.

The study should be a warning to people who work in intensive-care facilities or long-term care facilities, and to shift workers.

http://www.nature.com/news/bright-light-accelerates-ageing-in-mice-...

Comment by Dr. Krishna Kumari Challa on July 16, 2016 at 7:27am

Mice Watching "Touch of Evil" Teach Scientists About the Mind's Eye

By tracking mice neurons, scientists hope to understand consciousness

Comment by Dr. Krishna Kumari Challa on July 14, 2016 at 6:07am

Astronomers find a freak Frankenstein galaxy made of parts of other galaxies
The unassuming galaxy turns out to have a lot of parts taken from galaxies that came before.
About 250 million light-years away, there's a neighborhood of our universe that astronomers had considered quiet and unremarkable. But now, scientists have uncovered an enormous, bizarre galaxy possibly formed from the parts of other galaxies.

A new study to be published in the Astrophysical Journal reveals the secret of UGC 1382, a galaxy that had originally been thought to be old, small and typical. Instead, scientists using data from NASA telescopes and other observatories have discovered that the galaxy is 10 times bigger than previously thought and, unlike most galaxies, its insides are younger than its outsides, almost as if it had been built using spare parts.
"This rare, 'Frankenstein' galaxy formed and is able to survive because it lies in a quiet little suburban neighborhood of the universe, where none of the hubbub of the more crowded parts can bother it," said study co-author Mark Seibert of the Observatories of the Carnegie Institution for Science, Pasadena, California. "It is so delicate that a slight nudge from a neighbor would cause it to disintegrate."
As it turns out, UGC 1382, at about 718,000 light-years across, is more than seven times wider than the Milky Way. It is also one of the three largest isolated disk galaxies ever discovered, according to the study. This galaxy is a rotating disk of low-density gas. Stars don't form here very quickly because the gas is so spread out.

But the biggest surprise was how the relative ages of the galaxy's components appear backwards. In most galaxies, the innermost portion forms first and contains the oldest stars. As the galaxy grows, its outer, newer regions have the youngest stars. Not so with UGC 1382. By combining observations from many different telescopes, astronomers were able to piece together the historical record of when stars formed in this galaxy -- and the result was bizarre.

"The center of UGC 1382 is actually younger than the spiral disk surrounding it," Seibert said. "It's old on the outside and young on the inside. This is like finding a tree whose inner growth rings are younger than the outer rings."

The unique galactic structure may have resulted from separate entities coming together, rather than a single entity that grew outward. In other words, two parts of the galaxy seem to have evolved independently before merging -- each with its own history.
More galaxies like this may exist, but more research is needed to look for them.

"By understanding this galaxy, we can get clues to how galaxies form on a larger scale, and uncover more galactic neighborhood surprises".
- Astronomy.com

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