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Science Simplified!

                       JAI VIGNAN

All about Science - to remove misconceptions and encourage scientific temper

Communicating science to the common people

'To make  them see the world differently through the beautiful lense of  science'

Members: 22
Latest Activity: 16 hours ago

         WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING

     THIS  IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS                                               

“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”             

                    "Being a scientist is a state of mind, not a profession!"

                  "Science, when it's done right, can yield amazing things".

         The Reach of Scientific Research From Labs to Laymen

The aim of science is not only to open a door to infinite knowledge and                                     wisdom but to set a limit to infinite error.

"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.

Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.

If you are scientifically literate the world looks very different to you.

We do science and science communication not because they are easy but because they are difficult!

“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"

 Links to some important articles :

1. Interactive science series...

a. how-to-do-research-and-write-research-papers-part 13

b. Some Qs people asked me on science and my replies to them...

Part 6part-10part-11part-12, part 14  ,  part- 8

part- 1part-2part-4part-5part-16part-17part-18 , part-19 , part-20

part-21 , part-22part-23part-24part-25part-26part-27 , part-28

part-29part-30part-31part-32part-33part-34part-35part-36part-37,

 part-38part-40part-41part-42part-43part-44part-45part-46part-47

Part 48 part49Critical thinking -part 50 , part -51part-52part-53

part-54part-55part-57part-58part-59part-60part-61part-62part-63

part 64, part-65part-66part-67part-68part 69part-70 part-71part-73 ...

.......306

BP variations during pregnancy part-72

who is responsible for the gender of  their children - a man or a woman -part-56

c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7

d. science-s-rules-are-unyielding-they-will-not-be-bent-for-anybody-part-3-

e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9

f. why astrology is pseudo-science part 15

g. How Science is demolishing patriarchal ideas - part-39

2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes

3. Science communication series:

a. science-communication - part 1

b. how-scienitsts-should-communicate-with-laymen - part 2

c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3

d. the-importance-of-science-communication-through-art- part 4

e. why-science-communication-is-geting worse - part  5

f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6

g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7

h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8

i. science-writers-and-communicators-where-are-you - part 9

j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10

k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11

l.  golden-rules-of-science-communication- Part 12

m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13

n. an-informed-patient-is-the-most-cooperative-one -part 14

o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15

p. the-most-difficult-part-of-science-communication - part 16

q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17

r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18

s. is-post-truth-another-name-for-science-communication-failure?

t. why-is-it-difficult-for-scientists-to-have-high-eqs

u. art-and-literature-as-effective-aids-in-science-communication-and teaching

v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them

 ** qs-people-asked-me-on-science-and-my-replies-to-them-part-173

w. why-motivated-perception-influences-your-understanding-of-science

x. science-communication-in-uncertain-times

y. sci-com: why-keep-a-dog-and-bark-yourself

z. How to deal with sci com dilemmas?

 A+. sci-com-what-makes-a-story-news-worthy-in-science

 B+. is-a-perfect-language-important-in-writing-science-stories

C+. sci-com-how-much-entertainment-is-too-much-while-communicating-sc

D+. sci-com-why-can-t-everybody-understand-science-in-the-same-way

E+. how-to-successfully-negotiate-the-science-communication-maze

4. Health related topics:

a. why-antibiotic-resistance-is-increasing-and-how-scientists-are-tr

b. what-might-happen-when-you-take-lots-of-medicines

c. know-your-cesarean-facts-ladies

d. right-facts-about-menstruation

e. answer-to-the-question-why-on-big-c

f. how-scientists-are-identifying-new-preventive-measures-and-cures-

g. what-if-little-creatures-high-jack-your-brain-and-try-to-control-

h. who-knows-better?

i. mycotoxicoses

j. immunotherapy

k. can-rust-from-old-drinking-water-pipes-cause-health-problems

l. pvc-and-cpvc-pipes-should-not-be-used-for-drinking-water-supply

m. melioidosis

n.vaccine-woes

o. desensitization-and-transplant-success-story

p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!

q. swine-flu-the-difficlulties-we-still-face-while-tackling-the-outb

r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine

s. don-t-ignore-these-head-injuries

t. the-detoxification-scam

u. allergic- agony-caused-by-caterpillars-and-moths

General science: 

a.why-do-water-bodies-suddenly-change-colour

b. don-t-knock-down-your-own-life-line

c. the-most-menacing-animal-in-the-world

d. how-exo-planets-are-detected

e. the-importance-of-earth-s-magnetic-field

f. saving-tigers-from-extinction-is-still-a-travail

g. the-importance-of-snakes-in-our-eco-systems

h. understanding-reverse-osmosis

i. the-importance-of-microbiomes

j. crispr-cas9-gene-editing-technique-a-boon-to-fixing-defective-gen

k. biomimicry-a-solution-to-some-of-our-problems

5. the-dilemmas-scientists-face

6. why-we-get-contradictory-reports-in-science

7. be-alert-pseudo-science-and-anti-science-are-on-prowl

8. science-will-answer-your-questions-and-solve-your-problems

9. how-science-debunks-baseless-beliefs

10. climate-science-and-its-relevance

11. the-road-to-a-healthy-life

12. relative-truth-about-gm-crops-and-foods

13. intuition-based-work-is-bad-science

14. how-science-explains-near-death-experiences

15. just-studies-are-different-from-thorough-scientific-research

16. lab-scientists-versus-internet-scientists

17. can-you-challenge-science?

18. the-myth-of-ritual-working

19.science-and-superstitions-how-rational-thinking-can-make-you-work-better

20. comets-are-not-harmful-or-bad-omens-so-enjoy-the-clestial-shows

21. explanation-of-mysterious-lights-during-earthquakes

22. science-can-tell-what-constitutes-the-beauty-of-a-rose

23. what-lessons-can-science-learn-from-tragedies-like-these

24. the-specific-traits-of-a-scientific-mind

25. science-and-the-paranormal

26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?

27. how-the-brain-of-a-polymath-copes-with-all-the-things-it-does

28. how-to-make-scientific-research-in-india-a-success-story

29. getting-rid-of-plastic-the-natural-way

30. why-some-interesting-things-happen-in-nature

31. real-life-stories-that-proves-how-science-helps-you

32. Science and trust series:

a. how-to-trust-science-stories-a-guide-for-common-man

b. trust-in-science-what-makes-people-waver

c. standing-up-for-science-showing-reasons-why-science-should-be-trusted

You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum

( Please go through the comments section below to find scientific research  reports posted on a daily basis and watch videos based on science)

Get interactive...

Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.

Our mail ID: kkartlabin@gmail.com

Discussion Forum

What is a three body problem?

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 16 hours ago. 1 Reply

Q: What is a three body problem?Krishna: I don't know about  science fiction or movies that are made based on the theme, but I will tell you what it is based on science.  Systems with two objects…Continue

Your Biological Age Can Be Different From Your Actual (Chronological)Age!

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 19 hours ago. 6 Replies

Recently I have seen an old lady teasing an young girl who became breathless after climbing up a few steps.  "Look I am 78. But still I can climb steps with ease. I can go anywhere I want without any…Continue

How Soil Microorganisms Can Combat Desertification

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 20 hours ago. 1 Reply

 Soil Microbiology is the specialized subject I studied during my Post…Continue

DNA can be considered as a natural flame retardant and suppressant

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 1 Reply

Q: Is DNA fire-proof?Krishna: Research has shown that DNA is flame retardant (1). Yes, DNA can be considered as a natural flame retardant and suppressant.NORMALLY, COTTON FABRICS are highly…Continue

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Comment by Dr. Krishna Kumari Challa on June 1, 2022 at 8:28am

Science academies publish statements on primary concerns for international action ahead of the G7 summit

The science academies of the G7 states are calling for urgent international action to protect the ocean and polar regions and to accelerate decarbonization. In the healthcare sector, scientists demand increased global pandemic preparedness and the implementation of a One Health approach, which considers the health of humans, animals, plants and the wider environment as closely linked and interdependent. Their recommendations are set out in four statements which were submitted to the German federal government today at the Science7 Dialogue Forum 2022 in Berlin/Germany.

https://www.leopoldina.org/en/events/event/event/2962/

Comment by Dr. Krishna Kumari Challa on June 1, 2022 at 8:04am

A world first: Human liver was treated in a machine and then successfully transplanted

The Liver4Life research has developed a perfusion machine that makes it possible to implant a human organ into a patient after a storage period of three days outside a body. The machine mimics the human body as accurately as possible, in order to provide ideal conditions for human livers. A pump serves as a replacement heart, an oxygenator replaces the lungs and a dialysis unit performs the functions of the kidneys. In addition, numerous hormone and nutrient infusions perform the functions of the intestine and pancreas.

Like the diaphragm in the , the machine also moves the  to the rhythm of human breathing. In January 2020, the multidisciplinary Zurich research team—involving the collaboration of University Hospital Zurich (USZ), ETH Zurich and the University of Zurich (UZH)—demonstrated for the first time that perfusion technology makes it possible to store a liver outside the body for several days.

The team prepared the liver in the machine with various drugs. In this way, it was possible to transform the liver into a good , even though it was originally not approved for transplantation due to its poor quality. The multi-day perfusion—the mechanical circulation of the organ—enables antibiotic or hormonal therapies or the optimization of liver metabolism, for example. In addition, lengthy laboratory or tissue tests can be carried out without . Under normal circumstances, this is not possible because organs can only be stored for 12 hours if they are stored conventionally on ice and in commercially available perfusion machines.

As part of an approved individual treatment attempt, the doctors gave a  on the Swiss transplant waiting list the choice of using the treated human liver. Following his consent, the organ was transplanted in May 2021. The patient was able to leave hospital a few days after the transplantation and is now doing well.

Pierre-Alain Clavien, Transplantation of a human liver following 3 days of ex situ normothermic preservation, Nature Biotechnology (2022). DOI: 10.1038/s41587-022-01354-7www.nature.com/articles/s41587-022-01354-7

Comment by Dr. Krishna Kumari Challa on June 1, 2022 at 7:18am

Driver mutations vs passenger mutations

Comment by Dr. Krishna Kumari Challa on May 30, 2022 at 8:25am

Threat to 6G: Eavesdroppers can hack 6G frequency with DIY metasurface

Comment by Dr. Krishna Kumari Challa on May 29, 2022 at 12:38pm

Why the memory of fear is seared into our brains

Experiencing a frightening event is likely something you’ll never forget. But why does it stay with you when other kinds of occurrences become increasingly difficult to recall with the passage of time?

A team of neuroscientists have been studying the formation of fear memories in the emotional hub of the brain – the amygdala — and think they have a mechanism.

In a nutshell, the researchers found that the stress neurotransmitter norepinephrine, also known as noradrenaline, facilitates fear processing in the brain by stimulating a certain population of inhibitory neurons in the amygdala to generate a repetitive bursting pattern of electrical discharges. This bursting pattern of electrical activity changes the frequency of brain wave oscillation in the amygdala from a resting state to an aroused state that promotes the formation of fear memories.

If you are held up at gunpoint, your brain secretes a bunch of the stress neurotransmitter norepinephrine, akin to an adrenaline rush.

This changes the electrical discharge pattern in specific circuits in your emotional brain, centered in the amygdala, which in turn transitions the brain to a state of heightened arousal that facilitates memory formation, fear memory, since it’s scary. This is the same process, we think, that goes awry in PTSD and makes it so you cannot forget traumatic experiences.

https://www.nature.com/articles/s41467-022-28928-y

https://news.tulane.edu/pr/study-examines-why-memory-fear-seared-ou...

Comment by Dr. Krishna Kumari Challa on May 28, 2022 at 11:06am

How the brain links memories

Our brains rarely record single memories. Instead, they store memories in groups so that the recollection of one significant memory triggers the recall of others that are connected chronologically. As we age, however, our brains gradually lose this ability to link related memories.

Now researchers have discovered a key molecular mechanism behind this memory linking. They’ve also identified a way to restore this brain function genetically in aging mice — and an FDA-approved drug that achieves the same thing.

Published in the journal Nature, the findings suggest a new method for strengthening human memory in middle age and a possible early intervention for dementia.

Brain cells are studded with receptors. To enter a cell, a molecule must latch onto a specific receptor, which operates like a doorknob to provide access inside. The UCLA team focused on a gene that encodes a receptor for CCR5 molecules — the same receptor that HIV hitches a ride on to infect brain cells and cause memory loss in AIDS patients.

As people age, the amount of CCR5 expressed in the brain rises, and increased CCR5 gene expression reduces memory recall.

In the current study, researchers discovered a key mechanism underlying mice’s ability to link memories of their experiences in two different cages. A tiny microscope opened a window into the animals’ brains, enabling the scientists to observe neurons firing and creating new memories.

They found that boosting CCR5 gene expression in the brains of mice interfered with memory linking. The animals forgot the connection between the two cages. But when the scientists deleted the CCR5 gene in the animals, the mice were able to link memories that normal mice could not.

When the researchers gave maraviroc, a drug used for HIV patients, to older mice, the drug duplicated the effect of genetically deleting CCR5 from their DNA. The older animals were able to link memories again.

The finding suggests that beyond reversing the cognitive deficits caused by HIV infection, maraviroc can also be used to help restore middle-aged memory loss.

Yang Shen, Miou Zhou, Denise Cai, Daniel Almeida Filho, Giselle Fernandes, Ying Cai, André F. de Sousa, Min Tian, Nury Kim, Jinsu Lee, Deanna Necula, Chengbin Zhou, Shuoyi Li, Shelbi Salinas, Andy Liu, Xiaoman Kang, Masakazu Kamata, Ayal Lavi, Shan Huang, Tawnie Silva, Won Do Heo, Alcino J. Silva. CCR5 closes the temporal window for memory linkingNature, 2022; DOI: 10.1038/s41586-022-04783-1

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Comment by Dr. Krishna Kumari Challa on May 28, 2022 at 10:44am

T cells found to require rest and maintenance

T cells are the soldiers of the immune system, constantly on the ready to respond to a variety of threats, from viruses to tumors. However, without rest and maintenance T cells can die and leave their hosts more susceptible to pathogens,  scientists report May 27 in the journal Science.

Until pathogens are detected, T cells remain in a quiescent state. However, the molecular mechanisms that keep T cells inactive were previously unknown.

In the new study,  researchers show that a protein known as CD8a—which is found in a subset of T cells called CD8 cells—is crucial to keeping the cells in this dormant state. When scientists deleted this protein in mice, the protective CD8 cells were unable to enter a quiescent state and died, leaving the host vulnerable to infections.

Further, they identified another protein, PILRa, that provides a biochemical signal to CD8a. By disrupting this protein pair, both "memory" CD8 cells—cells that previously had been exposed to pathogens—and naïve cells died because they lacked the ability to stay in a quiescent state.

The researchers hope that understanding why this resting state is crucial to maintenance and survival of T cells can lead to improved immune system function.

They noted that as people age they tend to lose both naïve and memory T cells, making older individuals more susceptible to infections. It is possible that the inability of T cells to remain in a quiescent state could lead to people becoming more susceptible to infections and cancer, the authors suggest.

Linghua Zheng et al, The CD8α–PILRα interaction maintains CD8 + T cell quiescence, Science (2022). DOI: 10.1126/science.aaz8658

Comment by Dr. Krishna Kumari Challa on May 28, 2022 at 10:18am

Mixing drugs into oil-based gels could help the medicine go down

For most children and even some adults, swallowing pills or tablets is difficult. To make it easier to give those medicines, researchers  have created a drug-delivering gel that is much easier to swallow and could be used to administer a variety of different kinds of drugs.

The gels, made from plant-based oils such as sesame oil, can be prepared with a variety of textures, from a thickened beverage to a yogurt-like substance. The gels are stable without refrigeration, which could make them easier to get to children in developing nations, but they could also be beneficial for children anywhere, the researchers say. They could also help adults who have difficulty swallowing pills, such as older people or people who have suffered a stroke.

This platform will change our capacity for what we can do for kids, and also for adults who have difficulty receiving medication. Given the simplicity of the system and its low cost, it could have a tremendous impact on making it easier for patients to take medications.

Ameya R. Kirtane et al, Development of Oil-Based Gels as Versatile Drug Delivery Systems for Pediatric Applications, Science Advances (2022). DOI: 10.1126/sciadv.abm8478www.science.org/doi/10.1126/sciadv.abm8478

Comment by Dr. Krishna Kumari Challa on May 27, 2022 at 10:04am

Worms Live Longer with Mitochondria Powered by Light: Preprint

Increasing mitochondrial activity in worms by engineering a light-activated proton pump into the organelle’s membrane extends the animals’ lifespan without evidence of health decline, according to a preprint.

Mitochondrial dysfunction has long been associated with aging, making preventing or reversing the organelle’s decay a high priority for longevity researchers. One key target for such work is the decline in the organelle’s membrane potential: the difference in electrical charge between each side of the inner mitochondrial membrane that is essential for energy production. Now, research published May 12 as a bioRxiv preprint that has not yet been peer reviewed demonstrates that it’s possible to genetically engineer a light-activated proton pump into the mitochondria of Caenorhabditis elegans that maintains the voltage across the inner mitochondrial membrane as the worms age—and doing so, prolongs the animals’ lifespan.

The underlying technology was first described in 2020 research, in which University of Rochester Medical Center mitochondria researcher Andrew Wojtovich and his colleagues uncovered the proton pump’s impact on mitochondria. When they engineered the pump—naturally found in the cells of a fungus—into C. elegans, the animals’ mitochondrial membrane potential was increased, which ramped up the production of molecular fuel. The process, they showed, required neither metabolic substrates like glucose nor oxygen. Instead, the pump used light to fuel the movement of protons across the inner membrane, driving the synthesis of ATP. The team named this tool mitochondria-ON (mtON), which only works if the gene-edited animals are treated with light and supplemented with a vitamin A derivative called all-trans retinal, which acts as a cofactor for the pump. 

https://www.the-scientist.com/news-opinion/worms-live-longer-with-m...

Comment by Dr. Krishna Kumari Challa on May 27, 2022 at 9:48am

Why unprecedented bird flu outbreaks sweeping the world are concerning scientists

 

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