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Scientists at the University of California, San Diego, have developed a smartphone app that can detect early signs of Alzheimer’s disease and other neurological conditions. The app uses the phone’s near-infrared camera to track changes in the size of a person’s pupils at a sub-millimetre level. These measurements can then be used to assess that person’s cognitive condition.

As technology evolves, the eyes will prove more and more useful as a means of diagnosing all kinds of diseases and conditions because, by being transparent, the eye requires far less invasive methods of examination than other body parts.

But even without technology, it is possible to detect a number of health problems simply by looking at the eyes. Here are some of the warning signs.

Pupil size

The pupil responds instantly to light, becoming smaller in bright environments and larger in dimmer conditions. Sluggish or delayed responses in pupil size can point to several diseases that can include serious conditions such as Alzheimer’s disease, as well as effects of medications and evidence of drug use. Dilated pupils are common in those who use stimulant drugs, such as cocaine and amphetamine. Very small pupils can be seen in heroin users.

Red or yellow eyes

A change in the colour of the sclera (the “whites of the eyes”) suggests that something is not right. A red, bloodshot eye can be triggered by excess alcohol or drug abuse. It can also be caused by an irritation or infection that, in most cases, passes within days.

If the change in colour is persistent, it can signal a more serious infection, inflammation, or a reaction to contact lenses or their solutions. In extreme cases, a red eye indicates glaucoma, a sinister disease that can lead to blindness.

When the sclera become yellow, this is a most obvious sign of jaundice and a diseased liver. The underlying causes of jaundice vary widely. They include inflammation of the liver (hepatitis), genetic or autoimmune conditions, and certain medications, viruses or tumours.

Yellow sclera is a possible sign of liver disease. sruilk/Shutterstock

Red spot

A blood-red spot on the white of the eye (subconjunctival haemorrhage) can look frightening and is always the result of a small localised blood vessel that has burst. Most times, there is no known cause, and it disappears within days. However, it can also be an indication of high blood pressure, diabetes and blood-clotting disorders that cause excessive bleeding. Blood-thinning drugs such as aspirin can also be the cause, and if the problem is frequent, might suggest that the dosage should be reviewed.

A bleed in the eye is rarely as serious as it looks. 

Source: Google images

Ring around the cornea

A white or grey ring around the cornea is often linked to high cholesterol and an increased risk of heart disease. It can also reveal alcoholism and is sometimes seen in the eyes of older people, which is why the medical name given to it is arcus senilis.

Arcus senilis is common in older people. 

Fatty lump

Sometimes the most alarming features that can appear on the eyes are actually the most benign and easy to treat. A yellowish fatty lump that can appear on the white of the eye is a pinguecula (pronounced pin-GWEK-you-la), a small deposit of fat and protein that may be easily remedied by eye drops or removed by a simple operation.

A pterygium (pronounced tur-RIDGE-ium) that appears as a pinkish growth over the white of the eye is not a danger to sight until it starts to grow over the cornea (the coloured part of the eye).

Fortunately, pterygia grow very slowly. As with pinguecula, it can easily be removed. Indeed, it should be removed well before it reaches the cornea. If allowed to keep growing, the pterygium will form an opaque “film” over the cornea that will obstruct vision. One of the major causal factors for both pinguecula and pterygium is believed to be chronic exposure to ultraviolet light from the Sun.

A pinguecula is a yellowish raised growth on the conjunctiva. 

Image source: Google images

Bulging eyes

Bulging eyes can be part of a normal facial feature, but when eyes that were not previously bulging start to protrude forward, the most obvious cause is a problem with the thyroid gland and needs medical attention. A single eye that is bulging can be caused by an injury, infection or, more rarely, a tumour behind the eye.

Bulging eyes can be a sign of a thyroid problem, such as Graves’ disease

Image source: Google images

Swollen or twitching eyelids

The eyelids can also indicate many diseases. These are mostly related to minor conditions of the glands in the eyelids. A common condition is the stye or chalazion, which appears as a red lump on the upper and, less often, lower eyelid and is caused by a blocked oil gland. A stye generally disappears on its own or with warm compresses. If it persists, it needs to be removed with a simple procedure.

A twitching eyelid (ocular myokymia) can be an irritation, even an embarrassment, and often feels far worse than it looks. In most cases, it is perfectly harmless and can be linked to stress, nutrient imbalance or consuming too much caffeine.

Author: 

Professor and Deputy Dean, Research and Innovation, Anglia Ruskin University

This article is republished from The Conversation under a Creative Commons license. You can find the original article here: what-your-eyes-reveal-about-your-health

PS: I am adding a few more things to this ----

Toxoplasma gondii is probably the most successful parasite in the world today. This microscopic creature is capable of infecting any mammal or bird, and people across all continents are infected . Once infected, a person carries Toxoplasma for life. So far, we don’t have a drug that can eradicate the parasite from the body. 

Across the world, it’s estimated 30–50% of people are infected with Toxoplasma – and infections may be increasing .

How it affects the eye

Toxoplasma really likes the retina, the multi-layered nerve tissue that lines the eye and generates vision. Infection can cause recurring attacks of retinal inflammation and permanent retinal scarring. This is known as ocular toxoplasmosis.

Ocular Toxoplasmosis

Source: https://imagebank.asrs.org/file/3916/ocular-toxoplasmosis

Contrary to much that is written about ocular toxoplasmosis, medical research shows this condition usually affects healthy adults. However, in aged persons or people with a weakened immune system, or when contracted during pregnancy, it can be more severe.

An attack of active inflammation causes “floaters” and blurred vision. When the inflammation progresses to scarring, there may be permanent loss of vision.

In a study of patients with ocular toxoplasmosis seen at a large ophthalmology clinic, we measured reduced vision to below driving level in more than 50% of eyes, and 25% of eyes were irreversibly blind.

https://theconversation.com/one-in-three-people-are-infected-with-t...

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Getting Your Eyes Checked Could Help Prevent This 'Silent Killer' From Striking

REBEKKA HEITMAR AND CHRISTIAN FRENCH, THE CONVERSATION
24 JULY 2022

Most people over the age of 40 regularly see an optometrist. But while most see their optometrist for an eye exam, many don't realize just how much our eyes can tell someone about our health.

In fact, your eyes may actually be one of the first parts of our body to show signs of high blood pressure – often before most people are even aware they have the condition.

An estimated 1.3 billion people worldwide have hypertension – but only half of these people are aware of it or have been diagnosed. Many people may be unaware they have high blood pressure because it has few warning signs or symptoms. This is also why it's often called "the silent killer".

High blood pressure isn't something that develops suddenly. It's often the result of many years of an unhealthy lifestyle with poor diet, lack of physical activity, smoking, and excess alcohol consumption. Family history of high blood pressure, alongside other conditions – such as diabetes and kidney disease – are also risk factors.

If left untreated, high blood pressure can increase risk of heart disease (including heart attacks and heart failure), stroke, kidney disease, vascular dementia, as well as causing eye problems. This is why it's important to catch high blood pressure early – and regular eye exams could be one way to do this.

Pressure changes

There are several ways to find out if you have high blood pressure. You can get it checked by your doctor, at a pharmacy, or using a home testing kit. This is usually done with a stethoscope, arm cuff, or an automated arm cuff, which can be used at home.

The NHS advises people get their blood pressure checked every five years – though this may be yearly if a person is at greater risk of having high blood pressure.

But your optometrist may also be able to spot signs of high blood pressure – possibly even before your GP does.

When viewing inside the eye with a slit-lamp (a specialized microscope used during an eye exam) or taking a retinal photograph, many different parts of the eyes can be seen – including the small blood vessels.

These small blood vessels are very sensitive to changes in blood pressure and may become damaged as a result of high blood pressure – which may lead to blurry vision. High blood pressure may also cause a buildup of fluid beneath our retina, which may also affect the health of the eye.

During an eye exam, an optometrist may be able to measure the diameter of blood vessels to determine if a person is likely to have high blood pressure. If the optometrist takes a retinal photograph, signs of high blood pressure will be seen in red areas of hemorrhaging in the eyes.

The eye's circulation is very similar to the brain's circulation. This is because eyes developed from brain tissue, hence they're often referred to as "the window to the brain". This is also the reason why changes in the eye's blood vessels can be used as an early warning sign for what is likely to go on in the brain and elsewhere in the body.

But because changes in the eye's blood vessels can also be due to other diseases affecting the eyes (such as diabetes), any changes that your optometrist spots would need to be confirmed by a GP or at-home blood pressure device.

In order to diagnose someone with high blood pressure by looking at their eyes, optometrists will look for fluid build-up in the eye (which may lead to swelling), inflammation, and blood vessel dysfunction. They may also measure the diameter of blood vessels in the eyes to predict who is at higher risk of developing high blood pressure and cardiovascular disease.

Your optometrist may also ask you questions about your health during an exam – including if you have high blood pressure – to better identify risk factors for certain eye conditions. Someday, AI could even be used during regular eye exams to better identify those at risk of having a heart attack.

While a regular eye exam doesn't replace a regular health checkup with your doctor, it's often the first place that high blood pressure is picked up, as patients are often symptom-free.

Optometrists may also be able to catch signs of other diseases too – such as diabetes – which can also cause damage to the eyes.The Conversation

Rebekka Heitmar, Reader, Optometry and Vision Sciences, University of Huddersfield and Christian French, Senior Lecturer, Optometry, University of Hertfordshire.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Your eyes could reveal the first signs of many diseases


Melissa, a 30-year-old educator, came to the emergency department with a sudden onset of double vision. She had not been in an accident or suffered any trauma and had never experienced this symptom before. However, she noted that a few months earlier, the vision in one of her eyes had become blurred and then returned to normal shortly after. She told herself it was a sign of fatigue after a period of intense work on a screen.

After some basic optometric tests, then more advanced tests of visual perception, the visual episodes were thought to be related to multiple sclerosis. Melissa was then referred to a neuro-ophthalmology specialist who confirmed the diagnosis, and she was quickly treated.

Is Melissa's case unique? Over my 30 years working as an optometrist, I've seen many patients with different vision and eye health problems, the cause of which turned out to be an illness they didn't know they had.

As a professor at the School of Optometry at the Université de Montréal, I teach students that certain ocular symptoms can be linked to general health problems. Optometrists are trained to identify the various diseases that can manifest themselves through the eyes and to work with other health professionals to manage them.

Diabetes

Because diabetes will affect almost 8% of the population by 2030, screening is a crucial issue. However, it is estimated that diabetes is not generally diagnosed until six to 13 years after its onset. An eye health examination can shorten this delay since it is often possible to identify characteristic lesions of the disease at the back of the eye before other symptoms of diabetes appear.

Early diagnosis is crucial since within five years of diagnosis (i.e., 11 to 15 years after the onset of diabetes), 25% of patients with Type 1 () and 40% of those with Type 2 (adult diabetes) who are treated with insulin will develop eye lesions that can have a major effect on their vision. Early identification and rigorous monitoring of eye health significantly reduces the risk of blindness, which can happen when the disease is not treated.

Unmasking the silent killer

If  affects a significant number of patients without them knowing it, what can be said about  and high cholesterol? These two conditions significantly increase the risk of coronary heart disease or stroke in our societies.

The eye is the only place in the human body where  can be seen without having to make an incision or use invasive techniques.

In all these cases, very often the symptoms experienced by the patient are so few, or progress so slowly, that he or she considers them almost normal.

Normotensive or open-angle glaucoma

The absence of symptoms is also the norm for glaucoma. This pathology of the optic nerve is usually associated with excessive production of aqueous humor in the eye or a deficit in its evacuation.

The pressure inside the eye then increases and through different mechanisms leads to the loss of nerve fibers in the nerve. The visual field narrows very slowly (and therefore can go unnoticed), so the person ends up with tunnel vision after several years.

By the time this loss of vision affects them, it is often late, so the damage to the optic nerve can be very extensive. This damage is mainly ocular, although it can also be induced by the effect of certain drugs (such as cortisone).

Normotensive glaucoma is of a completely different nature. In this case, the pressure inside the eye remains normal but the nerve is still damaged. The mechanisms at play are different from those in chronic open-angle glaucoma.

Normotensive glaucoma is often associated with low blood pressure or conditions such as sleep apnea. If it is present, the patient must be referred to a family doctor for a thorough investigation.

The disease of the century

Because cancer is becoming so widespread and is expressed in so many ways, we call it the disease of the century. Cancers that affect the eye (retinoblastoma) can also cause metastases to the lungs and liver.

Here again, the disease often develops without symptoms until it is too late. So early detection is crucial, because the patient's very survival is at stake.

Other types of asymptomatic retinal pigment (shaped like a bear's paw) may be associated with cancer of the colon, which has a very negative prognosis if management is delayed.

A simple visual field measurement may reveal abnormalities that some patients are unaware of, or that they consider so benign they don't bother to report them. However, many visual field abnormalities hide brain tumors, such as pituitary adenoma, or nerve fibers compressed by blood vessels.

Abnormal eye movements, asymmetric pupillary responses, sudden reading problems or the appearance of diplopia are all yellow flags that require further ocular and neurological investigation.

Rather than the mirror of the soul, the eyes become an open window on our overall health. That makes regular consultations with an optometrist more important than ever, even when there are no symptoms. Many disorders can be detected and treated to either minimize illnesses or prevent them altogether.


This article is republished from THE CONVERSATION under a Creative Commons license. Read the original article.The Conversation

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