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Comment by Dr. Krishna Kumari Challa yesterday

Reprogrammed Human Stomach Organoids Secrete Insulin

Transplanting human gastric organoids engineered to release insulin in diabetic mice reduced hyperglycemia, offering a therapeutic avenue for type 1 diabetes.

An estimated 9.5 million people all over the world live with type 1 diabetes, wherein the beta cells in their pancreas cannot produce enough insulin to keep blood glucose in check. In the long run, elevated glucose can damage organs such as the kidneys, heart, and eyes. Over the past few decades, scientists have been studying how to generate functional insulin-secreting cells which could be transplanted into patients.

Now, researchers engineered human stomach organoids to secrete insulin. Transplanting these into diabetic mice reduced hyperglycemia. Their findings, published today in Stem Cell Reports, could help develop technologies to engineer a person’s own insulin-secreting cells for diabetes treatment.

Lu J, et al. Modeling in vivo induction of gastric insulin-secreting cells using.... Stem Cell Rep. 2025. 

Comment by Dr. Krishna Kumari Challa yesterday

Scientists recruit bed bugs as crime scene sleuths

Tropical bed bugs can retain human DNA for up to 45 days after feeding, enabling recovery of phenotypic traits such as gender, eye, hair, and skin color using STR and SNP markers. Their limited mobility and tendency to remain hidden make them valuable forensic tools at crime scenes, though their usefulness is restricted to recent events within a 45-day window.

Comment by Dr. Krishna Kumari Challa yesterday

Virus battles drug-resistant infections

Jumbo bacteriophages, viruses that infect bacteria, possess unique shielded compartments protecting their genetic material and can evade bacterial immune defenses. Advances in imaging have revealed these features, suggesting that engineered jumbo phages could offer effective therapies against drug-resistant bacterial infections, addressing a growing global health threat.

Thomas G. Laughlin et al, Architecture and self-assembly of the jumbo bacteriophage nuclear shell, Nature (2022). DOI: 10.1038/s41586-022-05013-4

Comment by Dr. Krishna Kumari Challa yesterday

How to turn water into wine using Raisins

Sun-dried raisins submerged in water can reliably ferment into wine due to a high abundance of Saccharomyces cerevisiae on their surfaces, unlike fresh grapes. Successful fermentation was observed only with sun-dried raisins, yielding higher ethanol concentrations and a dominance of alcohol-producing yeasts. Oil-coated commercial raisins do not support this process.

https://phys.org/news/2025-11-wine-raisins.html?utm_source=nwletter...

Comment by Dr. Krishna Kumari Challa yesterday

To show how it is possible that our sense of touch is activated purely by visual information, the researchers developed novel methods to analyze brain activity in 174 people while they watched films such as "The Social Network" and "Inception."Surprisingly, brain regions traditionally considered to process purely visual information showed patterns that reflected sensations on the viewer's own body, not just what appeared on screen. These visual regions contained "maps" of the body similar to those usually found in touch-processing areas of the brain. In other words, the "machinery" the brain uses to process touch is "baked in" to our visual system.The study found two ways these body maps line up with visual information. In dorsal (higher up) regions of the visual system, body maps match where things appear in our field of view: Parts of the brain tuned to feet sensations were also tuned to lower parts of the visual scene, while parts tuned to face sensations were also tuned to upper parts of the visual scene. In ventral (lower down) regions, the body maps match what body part someone is looking at, regardless of where it appears in the visual scene. Put simply, our visual system is intimately connected to our sense of touch, mapping what we observe onto the coordinates of our body.The researchers are particularly excited by the clinical applications of this research. Dr. Hedger said, "This discovery could transform how we understand conditions like autism."Many theories suggest that internally simulating what we see helps us understand other people's experiences, and these processes may work differently in autistic people. Traditional sensory tests are exhausting, especially for children or people with clinical conditions. We can now measure these brain mechanisms while someone simply watches a film, opening up new possibilities for research and diagnosis."

Part2

Comment by Dr. Krishna Kumari Challa yesterday

Why watching someone get hurt on screen makes you wince: How the brain triggers echoes of touch sensation

Many people say that seeing bodily injury on film makes them flinch, as if they "feel" it themselves. It is as if the sting leaps straight off the screen and into your skin. 

But explaining why and how this happens has puzzled scientists for a long time. Now, scientists have uncovered a major clue as to why. Parts of the brain originally thought to only process vision are also organized according to a "map" of the body, allowing what we see to trigger echoes of touch sensations. 

The study, published recently (Wednesday, 26 November), in the journal Nature, shows that watching movies can activate touch-processing regions of your own brain in a highly organized way. In short, your brain doesn't just watch, it simulates what it sees. 

When you watch someone being tickled or getting hurt, areas of the brain that process touch light up in patterns that match the body part involved. Your brain maps what you see onto your own body, 'simulating' a touch sensation even though nothing physical happened to you.

This cross-talk works in the other direction too. For example, when you navigate to the bathroom in the dark, touch sensations help your visual system create an internal map of where things are, even with minimal visual input. This 'filling in' reflects our different senses cooperating to generate a coherent picture of the world.

Nicholas Hedger, Vicarious body maps bridge vision and touch in the human brain, Nature (2025). DOI: 10.1038/s41586-025-09796-0. www.nature.com/articles/s41586-025-09796-0

Part1

Comment by Dr. Krishna Kumari Challa yesterday

To confirm feathers were the cause, the scientists also studied two related pheasant species that lack elaborate head plumage. In these birds, male and female fields of vision were identical. 

According to the researchers, the enlarged blind area of the Lady Amherst's and golden pheasant males leaves them more vulnerable to predation than females. This visual cost is the latest example of the handicap principle, an evolutionary idea that suggests that if a male can survive despite carrying a feature that puts it at a disadvantage, it must have superior genes.

"The reduced visual field in males compared to females in these pheasants, as a result of feather ornamentation, could be viewed as a relative handicap," wrote the researchers in their paper.

Alexandra E. R. Lamond et al, The visual impediment of cranial ornamentation in male Chrysolophuspheasants, Biology Letters (2025). DOI: 10.1098/rsbl.2025.0405

Part2

Comment by Dr. Krishna Kumari Challa yesterday

Flashy feathers may put some male pheasant species' lives at risk

The male Lady Amherst's pheasant knows how to put on a show when it comes to attracting mates. As well as elaborate courtship displays, they will unfurl their golden feathers to form a cape around their neck, which can prove irresistible to some females of the species. 

However, according to new research published in the journal Biology Letters, this spectacular ornamentation comes at a potentially life-threatening cost. It can severely restrict their field of vision, making them more vulnerable to predators.

As with most animals, vision is critical for birds, helping them forage for food, spot lurking predators, and keep an eye on rivals. For years, scientists understood that a bird's vision was largely shaped by its ecology (where it lives, what it eats, and how it forages) rather than its gender. But this research is the first to show that male and female birds see the world differently.

The study authors used a technique called ophthalmoscopic reflex to map the bird's visual field. This involves shining a light into a bird's eye and mapping where the reflection disappears, which marks the edge of its field of vision.

The team studied four captive Lady Amherst's pheasants and three golden pheasants (males of this species also have a colorful cape of feathers).

They found that males have a 30 to 40-degree smaller vertical range of binocular vision, which means they can't see as well above and in front of their heads. The researchers also discovered that males have a blind spot that is much larger than females, measuring over 114 square centimeters compared to about 21 square centimeters. The blind spot behind their head was also wider than that of females by about 10 degrees.

Part1

Comment by Dr. Krishna Kumari Challa yesterday

Persistent environmental toxins already accumulate in animal tissues during the fetal stage, research finds

Persistent organic pollutants (POPs) begin to accumulate in the tissues of mammals already during the fetal stage, according to new research.

  The animal-model study found that environmental toxins had built up in the tissues of sheep raised in clean organic production, and that the same substances were transferred in notable amounts to the developing fetuses' adipose tissue. 

Persistent environmental toxins, such as PCBs and DDT, remain in nature for long periods without breaking down. They can accumulate in the fatty tissues of organisms and bioaccumulate through the food chain. These substances were previously used in industry and as insecticides, and although their use is now strictly regulated, they remain widespread in the environment.

A study appearing in Environmental Research analyzed tissue samples from 15 organic ewes and their lambs shortly after birth, searching for the most common POPs.

Almost all of the substances investigated were detected in both adult sheep and lamb tissues. All the compounds identified were able to cross the placenta, and the transfer was so effective that concentrations in the lambs' tissues averaged 30–103% of those measured in the mothers. 

Because placental structure in sheep differs from that in humans, no direct conclusions can be drawn regarding human exposure. However, concentrations of POPs in adult human adipose tissue are on average higher than in sheep, underscoring the need for further research. 

In epidemiological studies, POP concentrations measured from umbilical cord blood after birth have been linked to obesity, metabolic syndrome and lower IQ 

Ella Vuoti et al, Adipose tissue deposition and placental transfer of persistent organic pollutants in ewes, Environmental Research (2025). DOI: 10.1016/j.envres.2025.123164

Comment by Dr. Krishna Kumari Challa yesterday

Mini-fridges on a nanoscale? New cooling technique could make computer chips more powerful

A new ion-based cooling method uses voltage-controlled nanopores in semiconductor membranes to drive selective ion flow, enabling localized heating or cooling at the nanoscale. This approach achieves temperature drops over 2 K and is compatible with current chip fabrication, offering improved thermal management and reduced environmental impact for advanced semiconductor devices.

Makusu Tsutsui et al, Gate-Tunable Ionothermoelectric Cooling in a Solid-State Nanopore, ACS Nano (2025). DOI: 10.1021/acsnano.5c13339

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