Sunderbans mangrove trees losing capacity to absorb CO2: Study
The vast mangrove forest in the Sunderbans is fast losing its capacity to absorb carbon dioxide, one of the main greenhouse gases, from the atmosphere due to rise in the salinity of water, rampant deforestation and pollution, a study has found.

The mangrove forest, marsh grass, phytoplanktons, molluscus and other coastal vegetation in the world's largest delta are the natural absorbers of carbon dioxide (CO2), according to the study.

The stored carbon in the plants is known as "Blue Carbons". The absorption of CO2 is a process which contributes to reduction of the warming of the earth and other ill effects of climate change.
The research study, "Blue Carbon Estimation in Coastal Zone of Eastern India - Sunderbans", was financed by the Union government and headed by noted marine scientist Abhijit Mitra.

The report took three years to prepare and it was submitted to the government last year.

The scientists involved in the study have sounded an alarm bell, especially in the central Sunderbans, one of the three zones into which the forest was divided for the study, the other two being western and eastern.

"The situation is quite alarming, especially in the central part. The capacity of the mangrove forest, especially the Byne species, to absorb carbon dioxide has eroded to a large extent. This will effect the entire ecosystem of the area," Sufia Zaman, a senior marine biologist who was a part of the team.
-PTI

Prof Sir Alec Jeffreys, who discovered DNA fingerprinting, win's the world’s oldest science prize
The man who discovered DNA fingerprinting has won the world's oldest science prize — Royal Society's Copley Medal.

In 1984, Prof Sir Alec Jeffreys stumbled on a method for distinguishing individuals based on their DNA. It was a discovery that went on to transform forensic science and resolve questions of identity and kinship.

He received the medal "for his pioneering work on variation and mutation in the human genome".

The Copley medal was first awarded by the Royal Society in 1731, 170 years before the first Nobel Prize. It is awarded for outstanding achievements in scientific research and has been awarded to eminent scientists such as Charles Darwin, Michael Faraday, Albert Einstein and Stephen Hawking.

In 1984 Jeffreys discovered a method of showing the variation between individuals' DNA, a technique which he developed and became known as genetic fingerprinting.

Himalayas ‘Too Seismic’ For Big Dams
Scientists have raised concerns that the ambitious dam projects planned in the Himalayan region do not adequately account for seismic activity
http://www.currentscience.ac.in/Volumes/106/12/1658.p

Elderly patients could benefit from pretreatment with imiquimod before seasonal influenza vaccination.
Scientists have found that treating elderly patients with imiquimod before immunizing them against influenza improved the protective effects of the vaccine. This study has been published in the journal Clinical Infectious Diseases.
In a study, a team led by Professor Yuen Kwok-yung, Chair Professor of Department of Microbiology, Li Ka Shing Faculty of Medicine of The University of Hong Kong (HKU) has discovered a simple and practical way of protecting elderly patients with medical illness from seasonal influenza. By applying the Toll-like receptor 7 agonist imiquimod before intradermal injection, the protection by flu vaccine is enhanced, thus decreasing the risk of hospitalization. Imiquimod is a safe immune-stimulatory drug, which has used topically to treat skin warts for many years.
http://cid.oxfordjournals.org/content/early/2014/07/20/cid.ciu582

Unmanned aerial vehicles or drones will soon fly over India's forests to monitor poaching, track wildlife and even count the population of tigers.

Scientists at the Wildlife Institute of India (WII) are coming up with a series of such drones which are being customised indigenously to suit different types of forest landscape.
Under a joint collaboration with the National Tiger Conservation Authority (NTCA) and international environment body WWF, they are preparing a detailed project report for introducing drone monitoring in 10 wildlife-rich areas across the country.

The primary objectives of these drones would be to track the movements of wildlife and monitor poaching.

They may also be used in counting the population of animals like tiger.
A drone can be put on autopilot mode and sent as far as 40-50 km deep into the forest where it can record images and videos and transmit them on a realtime basis. Its movement can also be controlled through a GPS-based system.

Such drones were recently tested successfully in Panna Tiger Reserve and Kaziranga.
Drones can also be used for night surveillance and tracking of many elusive and shy animals like the red panda and snow leopard, which are very rarely seen by the human eye in their natural wild habitat.

Travelling at a speed of 40 -100km per hour, the drones can be used for around 40-50 minutes.

Scientists turn a brown butterfly purple—in just six generations
Structural and pigment changes combine to turn brown into purple.
The results show that, although the individual structures are tiny and delicate, the butterfly's wing as a whole is remarkably robust and can easily undergo rearrangements that radically change its optical properties. In fact, as the authors point out, a bit of variability in these properties appears to be a normal part of the genetic background of these species. This natural variability means that evolution doesn't have to wait for a fortunate mutation to get to work.
http://arstechnica.com/science/2014/08/scientists-turn-a-brown-butt...

Bugs that can co-operate best with each other are most likely to be able to infect new species, including humans, a new study has found.

Scientists have discovered that bacteria co-operate with each other when causing infection, a finding that may help identify animal diseases that transmit to people such as anthrax and the superbug MRSA.

Bacteria interact by releasing molecules to help them adapt to their environment - for example, when killing competing infections in their victim. They co-ordinate these actions by releasing tiny amounts of chemicals as signals.

Bacteria that can co-operate to create an environment in which they can thrive are potentially able to infect lots of different species, including humans, researchers said.

Discovering why some diseases are better equipped to infect more species than others - and therefore could affect humans - could be valuable in predicting and managing health threats.

Most new human infections arise from diseases that transmit from animals to humans. Many of these cause serious infections and are difficult to control, such as anthrax and the superbug MRSA.

Research led by the University of Edinburgh used a combination of mathematical models and scientific analysis of genetic code in almost 200 types of bacteria.

They found that those bugs that carry lots of genes that help them to co-operate are best equipped to adapt to various environments.

"Humans have been able to colonise almost all of their planet by collectively modifying the environment to suit themselves. Our study shows bugs try to do the same - co-operation is important for the spread of bacteria to new species," Dr Luke McNally of the University of Edinburgh' School of Biological Sciences, who led the study, said.

The study was published in the journal Nature Communications.

Why Can’t You Remember Being a Baby?
The fast growth of young brains may come at the expense of infant memories
The results of a study , published in May in the journal Science, neuro-scientists Frankland and Josselyn think that rapid neuron growth during early childhood disrupts the brain circuitry that stores old memories, making them inaccessible. Young children also have an underdeveloped prefrontal cortex, another region of the brain that encodes memories, so infantile amnesia may be a combination of these two factors.

MIT creates magnetic microhair that lets water defy gravity

Researchers have created an elastic material bristling with microscopic strands of nickel that can direct the flow of liquids and light.

Two species of birds — carrion crows, which predominate in western Germany, and the closely related hooded crows that prevail further to the east, in Sweden and Poland can mate with each other, but they look very different — carrion crows are black, and hooded crows have black-and-gray bodies — and the birds strongly prefer mates of their own kind. For a long as anyone can remember, the two groups have remained distinct, save for a narrow band of habitat stretching from Denmark through eastern Germany to northern Italy where they sometimes intermingle.

The crows present a puzzling question to biologists, which gets to the heart of what it means to be a species: Given that hooded and carrion crows can mate and swap genes, how do the two groups maintain their individual identities? It’s as if you mixed red and yellow paint in a bucket but the two colors stubbornly refused to make orange.

In new research published in June in the journal Science, Wolf’s ( an Evolutionary Biologist) team has found that a surprisingly small chunk of DNA may hold the answer. A comparison of the carrion and hooded-crow genomes showed that the sequences are almost identical. Differences in just 82 DNA letters, out of a total of about 1.2 billion, appear to separate the two groups. Almost all of them are clustered in a small part of one chromosome. “Maybe just a few genes make a species what they are,” said Chris Jiggins, a biologist at the University of Cambridge in England, who was not involved in the study. “Maybe the rest of genome can flow, so species are much more fluid than we imagined before.”

The findings are striking because they suggest that just a few genes can keep two populations apart. Something within that segment of DNA stops black crows from mating with gray ones and vice versa, creating a tenuous mating barrier that could represent one of the earliest steps in the formation of new species. “They look very different and prefer to mate with their own kind, and all of that must be controlled by these narrow regions,” Jiggins said.
http://www.ncbi.nlm.nih.gov/pubmed/24948738
http://www.simonsfoundation.org/quanta/20140805-as-animals-mingle-a...

Crows aren’t alone in their behavio

Partial Recovery From Disorders of Consciousness
Traumatic Brain Injury Patients Treated with Anti-Spasm Agent Partially Recover from Disorders of Consciousness

At the International Neuromodulation Society’s 11th World Congress, Dr. Stefanos Korfias of the Department of Neurosurgery at the University of Athens will present the results of a clinical study led by Professor Damianos Sakas, which showed that two of six in-patients studied at Evangelismos Hospital in Athens steadily emerged from minimally conscious state after receiving intrathecal baclofen (ITB) after traumatic brain injury.

The drug relaxes spasticity that can result from brain injury and may be used to facilitate care, but is not normally used to restore function. The patients, a 24-year-old man and a 29-year-old man, had been in minimally conscious states for three years and 18 months, respectively. Their scores on a revised coma recovery scale (with a maximum of 23) increased from 10 – 19 and 11 – 22, respectively
http://www.newswise.com/articles/partial-recovery-from-disorders-of...
Electrical Brain Stimulation Can Restore Consciousness
Mild electrical stimulation might help brain-damaged patients communicate
http://www.scientificamerican.com/article/electrical-brain-stimulat...

Releasing genetically engineered fruit flies into the wild could prove to be a cheap, effective and environmentally friendly way of pest control, a new study has found.

New research by scientists at the University of East Anglia and Oxitec Ltd shows the release of genetically engineered male flies could be used as an effective population suppression method - saving crops around the world.

The Mediterranean fruit fly is a serious agricultural pest which causes extensive damage to crops.
The genetically engineered flies are not sterile, but they are only capable of producing male offspring after mating with local pest females - which rapidly reduces the number of crop-damaging females in the population.
This method presents a cheap and effective alternative to irradiation. This is a promising new tool to deal with insects which is both environmentally friendly and effective.
The method works by introducing a female-specific gene into the insects that interrupts development before females reach a reproductive stage.

Populations of healthy males and females can be produced in controlled environments by the addition of a chemical repressor.

If the chemical repressor is absent in the genetically engineered flies' diet, only males survive.

The surviving males are released, mate with local wild pest females and pass the female specific self-limiting trait onto the progeny resulting in no viable female offspring.

The research was published in the journal Proceedings of the Royal Society B.

Genomic-scale exchange of mRNA between a parasitic plant and its hosts
Abstract: Movement of RNAs between cells of a single plant is well documented, but cross-species RNA transfer is largely unexplored. Cuscuta pentagona (dodder) is a parasitic plant that forms symplastic connections with its hosts and takes up host messenger RNAs (mRNAs). We sequenced transcriptomes of Cuscuta growing on Arabidopsis and tomato hosts to characterize mRNA transfer between species and found that mRNAs move in high numbers and in a bidirectional manner. The mobile transcripts represented thousands of different genes, and nearly half the expressed transcriptome of Arabidopsis was identified in Cuscuta. These findings demonstrate that parasitic plants can exchange large proportions of their transcriptomes with hosts, providing potential mechanisms for RNA-based interactions between species and horizontal gene transfer.
http://www.sciencemag.org/content/345/6198/808
What this means: A vampire-like parasitic plant could reveal new secrets of plant communication. According to a study published Thursday in Science, species of the strangleweed plant are able to share genetic information in the form of messenger RNA molecules (mRNA) with the plants they invade. It's possible that this RNA shuffling is allowing for communication between the parasite and the host, and if we crack their codes we could exploit them to protect crops.

All babies lack sufficient vitamin K at birth, putting them at risk for severe bleeding in the brain or intestines until they get the vitamin by eating solid foods, typically around six months of age. The vitamin is essential for blood clotting, and a vitamin K injection after birth eliminates this bleeding risk.
Therefore, Vitamin K injections are recommended at birth in some countries because the vitamin does not cross the placenta well during pregnancy. The shot provides infants with enough vitamin K to last until they get sufficient amounts through diet. Vitamin K deficiency bleeding has always occurred but for years the condition was less common than other causes of infant death.

http://pediatrics.aappublications.org/content/112/1/191.full

Asthma and odors: The role of risk perception in asthma exacerbation
Fragrances and strong odors have been characterized as putative triggers that may exacerbate asthma symptoms and many asthmatics readily avoid odors and fragranced products. However, the mechanism by which exposure to pure, non-irritating odorants can elicit an adverse reaction in asthmatic patients is still unclear and may involve both physiological and psychological processes. The aim of this study was to investigate how beliefs about an odor's relationship to asthmatic symptoms could affect the physiological and psychological responses of asthmatics.
Results

Predictably, manipulations of perceived risk altered both the quality ratings of the fragrance as well as the reported levels of asthma symptoms. Perceived risk also modulated the inflammatory airway response.
Conclusions

Expectations elicited by smelling a perceived harmful odor may affect airway physiology and impact asthma exacerbations.
Highlights

•Asthmatics were exposed to an odor characterized as ‘asthmogenic’ or ‘therapeutic’.

•Irritation and annoyance ratings were elevated in the asthmogenic group.

•The asthmogenic group showed a rapid and persistent increase in airway inflammation.
http://www.jpsychores.com/article/S0022-3999%2814%2900252-9/abstract

Bypassing The Brain To Walk Again
Bypassing the spinal cord with an artificial neural connection enables subjects to control their legs by swinging their arms.
A Japanese research group has successfully made an artificial connection from the brain to the locomotion center, bypassing the spinal cord with a computer interface. This research, published in the Journal of Neuroscience, allowed subjects to perform a walking-like behavior in their legs by swinging their arms.
Neural networks in the locomotion center of the spinal cord are capable of producing rhythmic movements, such as swimming and walking, even when isolated from the brain. The brain controls the spinal locomotion center by sending commands to the spinal locomotion center to start, stop and change waking speed. In most cases of spinal cord injury, the loss of this link from the brain to the locomotion center causes problems with walking.
Although gait disturbance in individuals with spinal cord injury is attributed to the interruption of neural pathways from brain to the spinal locomotor center, neural circuits located above and below the lesion maintain most of their functions. An artificial connection that bridges the lost pathway and connects brain to spinal circuits has potential to ameliorate the functional loss.
http://www.ncbi.nlm.nih.gov/pubmed/25122909

How You Meditate Matters
Research shows that Vajrayana meditation can enhance cognitive performance, while Theravada meditation is relaxing.
not all meditation techniques produce similar effects of body and mind. Indeed, a study published in PLoS One demonstrates that different types of Buddhist meditation—namely the Vajrayana and Theravada styles of meditation—elicit qualitatively different influences on human physiology and behaviour, producing arousal and relaxation responses respectively.
The researchers had also observed an immediate dramatic increase in performance on cognitive tasks following only Vajrayana styles of meditation. They noted that such dramatic boost in attentional capacity is impossible during a state of relaxation. Their results show that Vajrayana and Theravada styles of meditation are based on different neurophysiological mechanisms, which give rise to either an arousal or relaxation response.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone....

A new study shows that weak electromagnetic stimulation could reorganize the brain with few side effects.
Researchers have shown that electromagnetic stimulation can alter brain organization which may make your brain work better.

In results from a study published in the Journal of Neuroscience, researchers from The University of Western Australia and the Université Pierre et Marie Curie in France demonstrated that weak sequential electromagnetic pulses (repetitive transcranial magnetic stimulation, or rTMS) on mice can shift abnormal neural connections to more normal locations.

The discovery has important implications for treatment of many nervous system disorders related to abnormal brain organisation such as depression, epilepsy and tinnitus.

http://www.researchgate.net/publication/264545425_Low-Intensity_Rep...

At higher levels, fluoride in drinking water can lead to pitted teeth and discoloration. It also makes bones brittle and more prone to fractures. And recent studies have also linked high levels of fluoride exposure with IQ deficits.

Mapping the Mind: An Interview with Eric Kandel from Imaginal Disc on Vimeo.

Forces driving epithelial wound healing
Abstract of the research paper:
A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and ‘purse-string’ contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate.
http://www.nature.com/nphys/journal/vaop/ncurrent/full/nphys3040.html

First Global Conference on Science Advice to Governments
Responding to the increasingly global nature of societal challenges, practitioners of science advice to governments formed a global network to share practice and strengthen their ties, at the first global conference on science advice to governments, which was held in Auckland, New Zealand on 28-29 August, 2014.
This Science Advice to Governments meeting had its origin in an editorial in Nature two years ago by James Wilsdon and Robert Doubleday
Summary of Panel 3: Science advice in the context of opposing political/ideological positions
Posted on August 28, 2014

One of the most difficult situations for science advisors to government is when evidence contradicts entrenched political (ideological) positions, whether these are within national, regional or local governments. Well established examples are seen in debates around controlled substances and public health.

Panellists discussed what models of science advice giving (ex: individual experts; commissioned reports; representative committees) have worked best in participating countries.
For more details please visit:
http://www.globalscienceadvice.org/

Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3622.html
A quick method detects by-products of the parasite's growth in the blood and is more portable and less error-prone than conventional tests
Jongyoon Han, a bioengineer at the Singapore-MIT Alliance for Research and Technology Centre, and his colleagues, have devised a diagnostic test that avoids many of the problems faced by today's anlysts. Their method, described in a paper published on 31 August in Nature Medicine, works with a tiny droplet — as little as 10 microlitres — of blood, and can provide a diagnosis in just a few minutes. In addition, it does not rely on the expertise of a technician.

When P. falciparum invades red blood cells and feeds on their contents, it breaks down haemoglobin into amino acids and haem, a chemical compound that contains iron. Free haem is toxic, so the parasite quickly converts it into an insoluble crystal known as haemozoin.

“Haemozoin crystals behave like little magnets,” explains Han. He and his team used a technique called magnetic resonance relaxometry (MRR) to detect the magnetic signal of haemozoin in human blood samples that they infected with P. falciparum, and in samples from mice infected withPlasmodium berghei, a mouse model of the disease.

MRR is a type of nuclear magnetic resonance (NMR) spectroscopy, a workhorse of chemical analysis. Although NMR machines are notoriously bulky, in recent years researchers have scaled them down to sizes small enough to fit on a benchtop. Another important step towards bringing the technique to the field, Han says, was that his team was able to detect haemozoin directly in the blood sample without first processing it in the lab.

A better understanding of plasma cell signaling could lead to better vaccines and therapies for autoimmune disease.
Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands
http://www.pnas.org/content/111/31/11431
Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool
http://www.nature.com/ncomms/2014/140630/ncomms5273/full/ncomms5273...
Scientists have uncovered the crucial role of two signalling molecules involved in the development and production of plasma cells. These discoveries, published in the Proceedings of the National Academy of Sciences of the United States of America and Nature Communications, advance the understanding of plasma cells and antibody response, and may lead to optimised vaccine development and autoimmune disease treatments.

A study in rats suggests that eating junk food weakens self control, leading to overeating and obesity.
Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning
http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00852/abs...
A range of animal and human data demonstrates that excessive consumption of palatable food leads to neuroadaptive responses in brain circuits underlying reward. Unrestrained consumption of palatable food has been shown to increase the reinforcing value of food and weaken inhibitory control; however, whether it impacts upon the sensory representations of palatable solutions has not been formally tested. These experiments sought to determine whether exposure to a cafeteria diet consisting of palatable high fat foods impacts upon the ability of rats to learn about food-associated cues and the sensory properties of ingested foods. We found that rats fed a cafeteria diet for 2 weeks were impaired in the control of Pavlovian responding in accordance to the incentive value of palatable outcomes associated with auditory cues following devaluation by sensory-specific satiety. Sensory-specific satiety is one mechanism by which a diet containing different foods increases ingestion relative to one lacking variety. Hence, choosing to consume greater quantities of a range of foods may contribute to the current prevalence of obesity. We observed that rats fed a cafeteria diet for 2 weeks showed impaired sensory-specific satiety following consumption of a high calorie solution. The deficit in expression of sensory-specific satiety was also present 1 week following the withdrawal of cafeteria foods. Thus, exposure to obesogenic diets may impact upon neurocircuitry involved in motivated control of behavior.

Conspicuous absences at global science advice meeting held recently.
The Science Advice to Governments conference, a gathering of scientists and science advisers from nearly 50 countries in Auckland, New Zealand: The conference explored how scientists should convey knowledge to policymakers, and what obstacles stand in their way. Discussions ranged from how to provide scientific input during humanitarian emergencies to how a country can effectively build science capacity.
However, there were no young scientists, women & scientists from most of the developing countries! And no politicians!There were several complaints. The gaps in representation at scientific conferences were, unfortunately, symptomatic of a wider problem. Although it would be beneficial to society to bring more women and young people from developing countries into the scientific community, they often have trouble breaking in because the “old boys’ network” is too quick to “discount” their work, which tends to explore new paradigms and use interdisciplinary approaches that challenge the status quo.
So?!
Let us think about the remedy.

What makes humans special?

The Milky Way is part of a much vaster galactic network than previously thought. The galaxy drifts along in a stream of galaxies on the outskirts of a newly identified collection of galaxy clusters, a supercluster named Laniakea. This supercluster — whose name means “heaven immeasurable” in Hawaiian — holds the mass of 100 million billion suns within a region that spans about 520 million light-years.

Astrophysicist R. Brent Tully of the University of Hawaii in Honolulu and colleagues sifted through data describing the positions and velocities of over 8,000 galaxies to get a fresh look at the Milky Way’s place in space. After accounting for the motion caused by the expansion of the universe, the team created a three-dimensional view of how gravity molds the galaxy’s cosmic neighborhood.

The new map, published in the Sept. 4 Nature, reveals Laniakea’s boundaries and weblike framework. The Milky Way lies along one of the lines of that web, in a tributary feeding one of many galactic rivers. Those streams converge in a gravitational valley roughly 200 million light-years away near two massive galaxy clusters: Norma and Centaurus. Their combined gravity appears to be drawing in other galaxies and clusters within Laniakea, including the Milky Way.

Milky Way connected to a vast network of galaxies
Astronomers name home galactic supercluster Laniakea
http://www.nature.com/nature/journal/v513/n7516/full/nature13674.html

Removing both breasts may not boost cancer survival
Women diagnosed with cancer in one breast who choose to have both removed may have no better survival rates than women who opt for breast-conserving surgery and radiation. In a study of nearly 190,000 women, the 10-year mortality rate was 18.8 percent for women who had double mastectomies, 20.1 for those who had single mastectomies and 16.8 percent for women who had lumpectomies plus radiation, researchers report in the Sept. 3 JAMA. The slightly lower survival rate among women who had only one breast removed may be influenced by socioeconomic status and race and ethnicity, the researchers say.
http://jama.jamanetwork.com/article.aspx?articleid=1900512&resu...

Rabies races up nerve cells
Virus may speed to the brain by hitching a ride with a protein
Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery
Abstract:
Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS). The strategy RABV uses to hijack the cellular transport machinery is still not clear. It is thought that RABV interacts with membrane receptors in order to internalize and exploit the endosomal trafficking pathway, yet this has never been demonstrated directly. The p75 Nerve Growth Factor (NGF) receptor (p75NTR) binds RABV Glycoprotein (RABV-G) with high affinity. However, as p75NTR is not essential for RABV infection, the specific role of this interaction remains in question. Here we used live cell imaging to track RABV entry at nerve terminals and studied its retrograde transport along the axon with and without the p75NTR receptor. First, we found that NGF, an endogenous p75NTR ligand, and RABV, are localized in corresponding domains along nerve tips. RABV and NGF were internalized at similar time frames, suggesting comparable entry machineries. Next, we demonstrated that RABV could internalize together with p75NTR. Characterizing RABV retrograde movement along the axon, we showed the virus is transported in acidic compartments, mostly with p75NTR. Interestingly, RABV is transported faster than NGF, suggesting that RABV not only hijacks the transport machinery but can also manipulate it. Co-transport of RABV and NGF identified two modes of transport, slow and fast, that may represent a differential control of the trafficking machinery by RABV. Finally, we determined that p75NTR-dependent transport of RABV is faster and more directed than p75NTR-independent RABV transport. This fast route to the neuronal cell body is characterized by both an increase in instantaneous velocities and fewer, shorter stops en route. Hence, RABV may employ p75NTR-dependent transport as a fast mechanism to facilitate movement to the CNS.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal...

Synthetic Fabrics Host More Stench-Producing Bacteria

Micrococcus bacteria thrive on the open-air lattice of synthetic fibers—where they sit chomping on the fatty acids in our sweat, turning them into shorter, stinkier molecules.
http://aem.asm.org/content/early/2014/08/12/AEM.01422-14.full.pdf+h...

Mutations: Stop that nonsense!
Cells can avoid the effects of so-called ‘nonsense’ mutations by several methods, including a newly discovered mechanism driven by microRNA molecules.
http://elifesciences.org/content/3/e04300

Fact or Fiction?: What the experts say...
Oxytocin Is the “Love Hormone”
Love is complicated, and so is the purported molecule d’amour
“Oxytocin is not the love hormone,” says Larry Young of Emory University. “It’s tuning us into social information and allowing us to analyze it at higher resolution.”

And from Shelley Taylor of the University of California, Los Angeles: “It’s never a good idea to map a psychological profile onto a hormone; they don’t have psychological profiles.”
http://www.scientificamerican.com/article/fact-or-fiction-oxytocin-...

How much does the Earth weigh?
According to Terry Quinn, emeritus director of the International Bureau of Weights and Measures, the Earth weighs about 7,000,000,000,000,000,000,000,000 Kg.
http://www.bbc.com/news/science-environment-29108451

Broken Signals Lead To Neurodegeneration
Neurogenerative diseases could be explained by modifications of the IP3 receptor which lock it in a closed state.
Scientists have discovered that a cell receptor widely involved in intracellular calcium signaling can be locked into a closed state by enzyme action, and that this locking may potentially play a role in the reduction of neuron signaling seen in neurodegenerative diseases such as Huntington’s and Alzheimer’s disease.
This insight could eventually lead to the development of new drug therapies for a number of neurodegenerative diseases that place a high burden on patients and society
Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors
http://www.pnas.org/content/early/2014/09/04/1409730111

Researchers have identified the mechanism the influenza A virus uses to introduce genetic diversity and increase its chances of survival.
Scientists have demonstrated that the influenza A virus makes use of its error-prone genetic replication to increase diversity, thereby facilitating viral survival under different selection pressures. This research has been published in Nature Communications.
Generation and characterization of influenza A viruses with altered polymerase fidelity
http://www.nature.com/ncomms/2014/140903/ncomms5794/full/ncomms5794...

Researchers in Japan have engineered a membrane with advanced features capable of removing harmful greenhouse gases from the atmosphere. Their findings, published in the journal Nature Communications, may one day contribute to lower greenhouse gas emissions and cleaner skies.
Scientists have developed a membrane that selects for carbon dioxide while allowing air to pass through 100 times faster than existing polymers.
Photo-oxidative enhancement of polymeric molecular sieve membranes
http://www.nature.com/ncomms/journal/v4/n5/full/ncomms2942.html

Where Is Human Evolution Taking Us?
http://www.scientificamerican.com/article/where-is-human-evolution-...

Scientists say ozone layer is recovering, credit phase-out of aerosol chemicals since the '80s
Earth protective but fragile ozone layer is finally starting to rebound, says a United Nations panel of scientists. Scientists hail this as rare environmental good news, demonstrating that when the world comes together it can stop a brewing ecological crisis.
http://montreal-protocol.org//new_site/en/index.php

The role of anti-oxidants in diabetes:
Antioxidants in Diabetes
http://www.brunswicklabs.com/blog/bid/354571/Antioxidants-in-Diabetes

Understanding anemia:
A critical role for mTORC1 in erythropoiesis and anemia
Abstract

Red blood cells (RBC) must coordinate their rate of growth and proliferation with the availability of nutrients, such as iron, but the signaling mechanisms that link nutritional state to RBC growth are incompletely understood. We performed a screen for cell types that have high levels of signaling through mTORC1, a protein kinase that couples nutrient availability to cell growth. This screen revealed that reticulocytes show high levels of phosphorylated ribosomal protein S6, a downstream target of mTORC1. We found that mTORC1 activity in RBCs is regulated by dietary iron, and that genetic activation or inhibition of mTORC1 results in macrocytic or microcytic anemia, respectively. Finally, ATP competitive mTOR inhibitors reduced RBC proliferation and were lethal after treatment with phenylhydrazine, an inducer of hemolysis. These results identify the mTORC1 pathway as a critical regulator of RBC growth and proliferation, and establish that perturbations in this pathway result in anemia.

http://elifesciences.org/content/early/2014/09/09/eLife.01913#sthas...

World's First Three-Dimensional Printed Car Made in Chicago
An Arizona company is the first to use 3-D printing to make a car
http://www.scientificamerican.com/article/world-s-first-three-dimen...

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This news has not been confirmed at when doubts were raised about the study. But still it is a beautiful explanation of expansion theory:

I Contain Multitudes

Our bodies are a genetic patchwork, possessing variation from cell to cell. Is that a good thing?
You are an assemblage of genetically distinctive cells, some of which have radically different operating instructions.
Even though each of your cells supposedly contains a replica of the DNA in the fertilized egg that began your life, mutations, copying errors and editing mistakes began modifying that code as soon as your zygote self began to divide. In your adult body, your DNA is peppered by pinpoint mutations, riddled with repeated or rearranged or missing information, even lacking huge chromosome-sized chunks. Your data is hopelessly corrupt!

Surprised to hear this? Click on the link to find out more...
http://www.simonsfoundation.org/quanta/20140821-i-contain-multitudes/