How scientists hauling logs on their heads may have solved a Chaco Canyon mystery!

Why did researchers carry a log weighing more than 130 pounds for 15 miles? Their feat of endurance could reveal new information about how ancient peoples hauled more than 200,000 heavy timbers to a site in the modern-day Southwest called Chaco Canyon.

In a new study, several researchers reenacted a small part of a trek that people in the Southwest United States may have made more than 1,000 years ago.

They described their experiment Feb. 22 in the Journal of Archaeological Science: Reports.

This is also done by sherpas in Nepal.

The researchers  they were hoping to solve an archaeological mystery that has perplexed researchers for decades: How did ancient peoples transport more than 200,000 heavy construction timbers over 60 miles to a famous site in the Southwest called Chaco Canyon?

The team's findings show that the key to this testament to human labor may have been simple devices called tumplines. These straps, which sherpas, or native mountain peoples of Nepal, still widely use today, loop over the top of the head. They help porters to support weight using the bones of their neck and spine rather than their muscles. Archaeological evidence suggests that ancient peoples in the Southwest employed tumplines woven from yucca plants to transport everyday items like food and water.

Tumplines allow one to carry heavier weights over larger distances without getting fatigued.

Chaco Canyon sits near the border between New Mexico and Colorado. Thousands of people, the ancestors of today's Diné, or Navajo, and Pueblo peoples, may have lived there from around A.D. 850 to 1200. They built "Great Houses," which were as much as four stories tall and contained hundreds of rooms.

But how this society got its construction supplies has been a long-standing mystery. Human porters would have needed to carry 16-foot-long wooden beams to Chaco Canyon by foot—following a network of ancient roads to sites like the Chuska Mountains to the west.

The team's findings open up a new understanding of the day-to-day lives of the people who shaped the Southwest more than a thousand years ago.

the team's results show that supplying Chaco Canyon with goods may not have been as back-breaking an undertaking as archaeologists once assumed.

As these guys showed, you don't have to be super trained to carry a log.

ames A. Wilson et al, Were timbers transported to Chaco using tumplines? A feasibility study, Journal of Archaeological Science: Reports (2023). DOI: 10.1016/j.jasrep.2023.103876

Combining forces to advance ocean science

All Living Cells Could Have The Molecular Machinery For a 'Sixth Sense'

Every animal on Earth may house the molecular machinery to sense magnetic fields, even those organisms that don't navigate or migrate using this mysterious 'sixth sense'.

Scientists working on fruit flies have now identified a ubiquitous molecule in all living cells that can respond to magnetic sensitivity if it is present in high enough amounts or if other molecules assist it.

The new findings suggest that magnetoreception could be much more common in the animal kingdom than we ever knew. If researchers are right, it might be an astonishingly ancient trait shared by virtually all living things, albeit with differing strengths.

That doesn't mean all animals or plants can actively sense and follow magnetic fields, but it does suggest that all living cells might, including ours.

How we sense the external world, from vision, hearing through to touch, taste, and smell, are well understood.

But by contrast, which animals can sense and how they respond to a magnetic field remains unknown. This study has made significant advances in understanding how animals sense and respond to external magnetic fields - a very active and disputed field.

Magnetoreception might sound like magic to us, but plenty of fish, amphibians, reptiles, birds, and other mammals in the wild can sense the tug of Earth's magnetic field and use it to navigate space.

Because this force is essentially invisible to our species, it took a remarkably long time for scientists to notice it.

Only in the 1960s did scientists show that bacteria can sense magnetic fields and orient themselves in relation to those fields; in the 1970s, we found that some birds and fish follow Earth's magnetic field when migrating.

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Even to this day, however, it's still unclear how so many animals achieve these incredible feats of navigation.

In the 1970s, scientists suggested that this magnetic-compass sense could involve radical pairs, molecules with unpaired outer shell electrons that form a pair of entangled electrons whose spins are altered by the Earth's magnetic field.

Twenty-two years later, that study's lead author co-authored a new paper proposing a specific molecule in which the radical pairs could be formed.

This molecule – a receptor in the retina of migrating birds called a cryptochrome – can sense light and magnetism, and it seems to work through quantum entanglement.

In basic terms, when a cryptochrome absorbs light, the energy triggers one of its electrons, pushing it to occupy one of two spinning states, each of which is differently influenced by Earth's geomagnetic field.

Cryptochromes have been a leading explanation for how animals sense magnetic fields for two decades, but now researchers at the Universities of Manchester and Leicester have identified another candidate.

Manipulating the genes of fruit flies, the team found that a molecule called Flavin Adenine Dinucleotide (FAD), which usually forms a radical pair with cryptochromes, is actually a magnetoreceptor in and of itself.

This basic molecule is found at differing levels in all cells, and the higher the concentration, the more likely it is to impart magnetic sensitivity, even when cryptochromes are lacking.

In fruit flies, for instance, when FAD is stimulated by light, it generates a radical pair of electrons that are responsive to magnetic fields.

However, when cryptochromes are present alongside FADs, a cell's sensitivity to magnetic fields increases. The findings suggest that cryptochromes are not as essential as we thought for magnetoreception.

That shows cells can, at least in a laboratory, sense magnetic fields through other ways."

The discovery could help explain why human cells show sensitivity to magnetic fields in the lab. The form of cryptochrome present in the cells of our species' retina has proved capable of magnetoreception at a molecular level when expressed in fruit flies.

However, this doesn't mean humans utilize that function, nor is there evidence that cryptochrome guides our cells to line up along magnetic fields in the lab.

Tissue engineering: Developing bioinspired multi-functional tendon-mimetic hydrogels

Materials scientists work to develop advanced biological materials for medical devices and tissue engineering platforms to emulate natural biological tissue architectures via materials engineering. However, the natural tissue architecture has a variety of characteristics that are difficult to synthetically replicate. The architecture of tendons relies on the load-bearing capacities of the musculoskeletal system to provide biophysical cues that translate into cellular behaviors via interfacial interactions. In the past decade, researchers had devoted extensive research efforts to engineer tendon-mimetic materials with high structural anisotropy.

In a new report now published in Science Advances,  a research team in physics, mechanical engineering, electrical and electronic engineering reported the development of multifunctional tendon-mimetic hydrogels by assembling aramid nanofiber composites. 

The anisotropic composite hydrogels (ACH) contained stiff nanofibers and soft polyvinyl alcohol moieties to mimic biological interactions that typically occur between collagen fibers and proteoglycans  in tendons. The team was bioinspired by natural tendons to develop hydrogels with a high elastic modulus, strength and fracture toughness.

The researchers biofunctionalized these material surfaces with bioactive molecules to present biophysical cues to impart behavioral similarities to those of cell attachment. Additionally, the soft bioelectronic components integrated on the hydrogels facilitated a variety of physiological benefits. Based on the outstanding functionality of the tendon-mimetics, the team envisioned broader applications of the materials in advanced tissue engineering to form implantable prosthetics for human-machine interactions.

Mingze Sun et al, Multifunctional tendon-mimetic hydrogels, Science Advances (2023). DOI: 10.1126/sciadv.ade6973

Jeong-Yun Sun et al, Highly stretchable and tough hydrogels, Nature (2012). DOI: 10.1038/nature11409

Study finds common artificial sweetener linked to higher rates of heart attack and stroke

New research showed that erythritol, a popular artificial sweetener, is associated with an increased risk of heart attack and stroke. Findings were published today in Nature Medicine.

Researchers studied more than 4,000 people in the U.S. and Europe and found those with higher blood erythritol levels were at elevated risk of experiencing a major adverse cardiac event such as heart attack, stroke or death. They also examined the effects of adding erythritol to either whole blood or isolated platelets, which are cell fragments that clump together to stop bleeding and contribute to blood clots. Results revealed that erythritol made platelets easier to activate and form a clot. Pre-clinical studies confirmed ingestion of erythritol heightened clot formation.

Artificial sweeteners, such as erythritol, are common replacements for table sugar in low-calorie, low-carbohydrate and "keto" products. Sugar-free products containing erythritol are often recommended for people who have obesity, diabetes or metabolic syndrome and are looking for options to help manage their sugar or calorie intake. People with these conditions also are at higher risk for adverse cardiovascular events like heart attack and stroke.

Erythritol is about 70% as sweet as sugar and is produced through fermenting corn. After ingestion, erythritol is poorly metabolized by the body. Instead, it goes into the bloodstream and leaves the body mainly through urine. The human body creates low amounts of erythritol naturally, so any additional consumption can accumulate.

Measuring artificial sweeteners is difficult and labeling requirements are minimal and often do not list individual compounds. Erythritol is "Generally Recognized As Safe (GRAS)" by the FDA, which means there is no requirement for long-term safety studies.

The authors note the importance of follow-up studies to confirm their findings in the general population. The study had several limitations, including that clinical observation studies demonstrate association and not causation.

This study shows that when participants consumed an artificially sweetened beverage with an amount of erythritol found in many processed foods, markedly elevated levels in the blood are observed for days—levels well above those observed to enhance clotting risks. It is important that further safety studies are conducted to examine the long-term effects of artificial sweeteners in general, and erythritol specifically, on risks for heart attack and stroke, particularly in people at higher risk for cardiovascular disease.

 Stanley Hazen, The artificial sweetener erythritol and cardiovascular event risk, Nature Medicine (2023). DOI: 10.1038/s41591-023-02223-9. www.nature.com/articles/s41591-023-02223-9

Tiny environmental plastic particles in mom's food reach unborn children

Nanoscale plastic particles like those that permeate most food and water pass from pregnant rats to their unborn children and may impair fetal development, according to a  study that suggests the same process happens in humans.

Erosion chips microscopic particles off the billions of tons of plastics that are exposed to the elements in the environment. These particles mix with the food we eat and the air we breathe. A typical person ingests a credit card's worth of them every week.

Previous studies in pregnant laboratory animals have found adding these plastics to food impairs their offspring in numerous ways, but those studies didn't determine whether mothers passed the plastics to their children in utero.

The study provided specially marked nanoscale plastics to five pregnant rats. Subsequent imaging found that these nanoplastic particles permeated not only their placentas but also the livers, kidneys, hearts, lungs and brains of their offspring.

These findings demonstrate that ingested nanoscale polystyrene plastics can breach the intestinal barrier of pregnant mammals, the maternal-fetal barrier of the placenta and all fetal tissues. Future studies will investigate how different types of plastics cross cell barriers, how plastic particle size affects the process and how plastics harm fetal  development, the researchers said.

 Chelsea M. Cary et al, Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications, Nanomaterials (2023). DOI: 10.3390/nano13040720

Researchers discover the mechanism by which tumor cells become resistant to chemotherapy in colorectal cancer

 Platinum-based chemotherapy, which is used to treat advanced colorectal cancer, accumulates in the healthy cells surrounding the cancer cells and, as a result, can reduce tumor sensitivity to treatment. This is demonstrated by a study published in the journal Nature Communications.

 A large number of cancer patients are treated with platinum-based therapy. However, many tumors are capable of developing resistance to treatment. In this study, the researchers examined tumor samples from patients and pre-clinical models of colorectal cancer to better understand the resistance to platinum-based therapy. They observed that platinum accumulates prominently in the healthy cells that surround the cancer cells, particularly in fibroblasts, the cells that contribute to tissue formation. Furthermore, this accumulation persists for more than two years after treatment has been completed. This discovery was made using techniques developed in geology and applied to biological samples.

The effect of platinum on fibroblasts
The researchers were able to demonstrate how the accumulation of platinum in the fibroblasts induced the activation of certain genes associated with a poor response to chemotherapy and tumor progression. Among them, the TGF-β protein redirected these fibroblasts to support cancer cells aggressiveness and resistance to treatment. 

There are currently no predictive biomarkers of benefit from chemotherapy in colorectal cancer. The analysis of about thirty patients before and after chemotherapy presented in this study reveals that periostin levels are an indicator of TGF-β activity in fibroblasts and serve as a robust marker of response to chemotherapy. Indeed, treatment benefit was significantly reduced in patients with elevated periostin levels before and/or after chemotherapy. Accordingly, chemotherapy was found to be less effective in tumors with high levels of periostin in pre-clinical colorectal cancer models.

The researchers are now working on developing a novel approach to improve the efficacy of chemotherapy in colorectal cancer.

This study is an important step toward understanding why chemotherapy does not work the same way in all cancer patients, and how to prevent or reverse resistance. This work is also essential in demonstrating that cancer treatment must take into account not only the cancer cells but also the healthy cells in the tumor. The next critical step will be to develop pharmacological strategies that act on the cancer cell and modulate the microenvironment in favor of tumor elimination.

 Jenniffer Linares et al, Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy, Nature Communications (2023). DOI: 10.1038/s41467-023-36334-1

Your pets leaking information about you? Yes, considering this:

Pet and animal-related apps are creating cybersecurity risks to their owners, new research has shown.

While being able to trace your cat and dog may be an attractive benefit to many pet owners as it can provide peace of mind, allowing a third party to track your movements may be much less attractive.

Computer scientists 

have exposed multiple security and privacy issues by evaluating 40 popular Android apps for pets and other companion animals as well as farm animals. The results show that several of these apps are putting their users at risk by exposing their login or location details. Password vulnerability was one of the areas exposed by the team. They identified three applications that had the user's login details visible in plain text within non-secure HTTP traffic. This means that anyone is able to observe the internet traffic of someone using one of these apps and will be able to find out their login information. In addition to login information, two of the apps also showed user details, such as their location, that may enable someone to gain access to their devices and risk a cyber-attack. Another area of concern identified in the study was the use of trackers. All but four of the applications were found to feature some form of tracking software. A tracker gathers information on the person using the application, on how they use it, or on the smartphone being used. The scientists also warn that the apps perform very poorly in terms of notifying the user of their privacy policy. Their analysis shows that 21 of the apps are tracking the user in some way before the user even has a chance to consent to this, violating current data protection regulations.

Scott Harper et al, Security and Privacy Concerns of Pet Tech Users, Proceedings of the 12th International Conference on the Internet of Things (2023). DOI: 10.1145/3567445.3571102

Scot Harper et al, Are Our Animals Leaking Information About Us? Security and Privacy Evaluation of Animal-related Apps, IEEE European Symposium on Security and Privacy Workshops (EuroS&PW) (2022). DOI: 10.1109/EuroSPW55150.2022.00012

'Dead zone' within tumor promotes cancer spread, helped by a protein secreted by cancer cells

A tumor's necrotic core contains factors that appear to promote metastasis, or the seeding of tumors cells throughout the body, according to a new study in rats by researchers. 

Tumor necrotic cores are a fairly common phenomenon, but they haven't been linked to cancer metastasis until recently. This research put together observations other people have made into the specific context of breast cancer metastasis. It shows a link between necrosis, circulating tumour cells and cancer metastasis.

Necrotic cores are tumors that are dying from the inside out, and they make for a perfect environment for cancer to spread.

Dead zones of tumors have leaky blood vessels, hypoxia or low levels of oxygen and the recruitment of immune cells, some of which have been shown to help cancer cells spread. What the researchers think is happening is that the necrotic core is mostly a dead zone, but it also has some surviving tumour cells that help the cancer disseminate in the body.

Surgeons, pathologists, radiologists, clinicians and researchers often come across necrotic cores in their line of work and they're usually not a good sign.

Necrosis is a clinical finding seen in aggressive tumors that grow quickly. 

When doctors see it in a patient's biopsy, it means this is a dangerous tumor that needs to be treated aggressively. But necrosis isn't only something seen in large, late-stage tumours. It can happen in early-stage and small tumours too.

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Researchers developed a new rat model of breast cancer metastasis to study the necrotic core of tumors. Over several weeks, they tracked the progression of circulating tumor cells (CTCs), which is a measure of whether the cancer cells are escaping into the bloodstream to spread throughout the body. They found zero CTCs at the first two time points examined (after 13 and 17 days), but that changed by the fourth time point at 27 days.

Suddenly, they found hundreds of CTCs. They linked the increase in cancer cells with when the primary tumour developed a large central area of necrosis.

Further investigation showed a stark difference in gene expression between the necrotic and the non-necrotic regions of the tumour.

Scientists  found that a gene which encodes angiopoietin-like 7, a secreted protein, was the most enriched tumour-derived gene in the necrotic and regions next to necrotic regions of the tumour.

The researchers found that this single protein, angiopoietin-like-7, remodels the tumour microenvironment, somehow encouraging the tumour cells to grow past their nutrient limits, undergo necrosis and start spreading to other parts of the body.

They then did experiments to see how controlling the protein would impact necrosis.

When they suppressed the expression of this protein in the tumours, there was a dramatic reduction of necrotic tumour area. Suppression of angiopoietin-like 7, or A-7, also reduced circulating tumour cells to almost zero and reduced distant metastases and dilated, large blood vessels.

This research not only showed A-7 regulates the development of central necrosis in the primary tumour, but also the development of dilated blood vessels which could be helping the dissemination of circulating tumor cells and metastasis.

Beyond the surprise of such an important mechanism to necrosis, these findings unveiled the potential for a new targeted treatment for patients.

 Yamamoto, Ami et al, Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7, Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2214888120. doi.org/10.1073/pnas.2214888120

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Breathing is going to get tougher as hotter temps mean more air pollution

 When global temperatures increase by 4°C, harmful plant emissions and dust will also increase by as much as 14%, according to new  research.

The research does not account for a simultaneous increase in human-made sources of air pollution, which has already been predicted by other studies.

Human beings can change their behaviour. We can switch to electric cars. But that may not change air pollution from plants or dust.

Details of the degradation in future air quality from these natural sources have now been published in the journal Communications Earth & Environment. About two-thirds of the future pollution is predicted to come from plants.

All plants produce chemicals called biogenic volatile organic compounds, or BVOCs. The smell of a just-mowed lawn, or the sweetness of a ripe strawberry, those are BVOCs. Plants are constantly emitting them. 

On their own, BVOCs are benign. However, once they react with oxygen, they produce organic aerosols. As they're inhaled, these aerosols can cause infant mortality and childhood asthma, as well as heart disease and lung cancer in adults. There are two reasons plants increase BVOC production: increases in atmospheric carbon dioxide and increases in temperatures. Both of these factors are projected to continue increasing. To be clear, growing plants is a net positive for the environment. They reduce the amount of carbon dioxide in the atmosphere, which helps control global warming.

BVOCs from small gardens will not harm people. It's the large-scale increase in carbon dioxide that contributes to the biosphere increasing BVOCs, and then organic aerosols.

The second-largest contributor to future air pollution is likely to be dust from the Saharan desert. In scientists' models, an increase in winds is projected to loft more dust into the atmosphere. 

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As the climate warms, increased Saharan dust is likely to get blown around the globe, with higher levels of dust in Africa, the eastern U.S., and the Caribbean. Dust over Northern Africa, including the Sahel and the Sahara, is likely to increase due to more intense West African monsoons.

Both organic aerosols and dust, as well as sea salt, black carbon, and sulfate, fall into a category of airborne pollutants known as PM_2.5, because they have a diameter of 2.5 micrometers or less. The increase in naturally sourced PM_2.5 pollution increased, in this study, in direct proportion to CO₂ levels.

The more we increase CO₂, the more PM_2.5 we see being put into the atmosphere, and the inverse is also true. The more we reduce, the better the air quality gets.

For example, if the climate warms only 2°C, the study found only a 7% increase in PM_2.5. All of these results only apply to changes found in air quality over land, as the study is focused on human health impacts.

The researchers hope the potential to improve air quality will inspire swift and decisive action to decrease CO₂ emissions. Without it, temperatures may increase 4°C by the end of this century, though it's possible for the increase to happen sooner.

If things go on like this, in the future, make sure you get an air purifier. 

James Gomez et al, The projected future degradation in air quality is caused by more abundant natural aerosols in a warmer world, Communications Earth & Environment (2023). DOI: 10.1038/s43247-023-00688-7

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Child didn’t die of global bird-flu variant

An 11-year-old girl in Cambodia who died after being infected with avian influenza A (H5N1) had a different variant from that causing mass deaths in birds globally. The strain she was carrying is endemic to the region, and last infected people in Cambodia about a decade ago. Investigations are under way into why the virus has spilled over from birds to people again. “Hopefully this is an isolated incident, but it could be indicative of a larger issue,” says virologist Erik Karlsson at the Pasteur Institute of Cambodia in Phnom Penh.

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Hints that flu arose underwater

Corals, sturgeon and other aquatic creatures harbour signs of infection by influenza and its distant relatives. A genetic analysis reveals that the virus family probably originated hundreds of millions of years ago in primordial aquatic ... that evolved well before the first fishes. It’s not clear whether influenza moved onto land with early terrestrial vertebrates, or jumped from sea to land more recently.

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The molecule that kickstarted life

For more than 15 years, scientists have been on a quest: create a functional ‘protoribosome’, a reconstructed version of the protein-building machine that many t.... The modern ribosome is a key ingredient of life as we know it because it translates genetic information into proteins. At its heart sits a small RNA pocket that some think might be closest to what the very first ribosome looked like. Now, there’s proof that some reconstructed protoribosome-like RNAs can link amino acids — the first step to making proteins. Some scientists say there are other ways for proteins to emerge, without a ribosome. But others are already thinking about repurposing these simple machines to manufacture new kinds of biomolecule.

Satellite images show coastal algae blooms have grown larger over past two decades

A team of Earth scientists affiliated with multiple institutions has found that coastal algae blooms (also known as phytoplankton blooms) have been getting bigger over the past couple of decades. In their study, published in the journal Nature, the group analyzed satellite data supplied to them by NASA to compare the size and frequency of algae blooms along the coasts of the world's continents.

Algae blooms are accumulations of algae in a shared area atop a water source. Algae are aquatic plants that contain chlorophyll, but have no leaves, roots, stems, vascular tissue or flowers. They vary in size, from single-celled species to large strands of seaweed. They can have different colors and can inhabit either fresh or saltwater systems. Algae blooms grow larger as their food source grows, particularly nitrogen and phosphorus, both of which are supplied indirectly through human sources such as fertilizer runoff. Prior research has shown that algae blooms can serve as a food source for some sea creatures, but they can also cause problems, such as carrying and dispersing toxic material. Such toxins have been found to accumulate in ocean networks, sometimes leading to oxygen depletion, which can lead to ocean dead zones. In this new effort, the research team found evidence that algae blooms are getting larger, which suggests fertilizer runoff has been increasing.

The work involved studying satellite images obtained from NASA's Aqua satellite over the years 2003 to 2020. By comparing such blooms over time, they found them to be growing at an increasing rate of 59.2%, globally. They also found that as of 2020, the combined size of all ocean-based algae blooms was 31.47 million km², which, they note, is approximately 8.6% of total ocean surface area.

The researchers also found patterns of increase—the areas where the water temperatures were rising the fastest were the same areas where the algae blooms were growing the fastest. Additionally, they found associations between sea surface temperatures, ocean circulation and the frequency of algae blooms.

'Rivers in the sky' shape African climate

East Africa is much drier than other tropical land regions, including the Amazon and Congo rainforests. The geography of East Africa was always thought to make the region dry and susceptible to drought, but the precise mechanism has been elusive until now. This research demonstrates the east to west river valleys are a crucial factor in the low annual rainfall.

Normally, when we think of valleys and water, we think of the rivers that flow along the ground. In East Africa, deep valleys, such as the Turkana Valley, channel strong winds and create invisible rivers in the sky. These invisible rivers carry millions of tons of water vapor, the key ingredient for rainfall.

New experiments show the valleys affect climate on a continental scale. It can't rain equally everywhere, and the valleys help to sustain high rainfall in the Congo basin, while leaving East Africa prone to drought.

Callum Munday et al, Valley formation aridifies East Africa and elevates Congo Basin rainfall, Nature (2023). DOI: 10.1038/s41586-022-05662-5

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Social animals should limit individuality to conform with the behaviour of the group, says study

Scientists  have observed that group safety was improved when animals paid attention to the behaviours of each other.

Their findings, accepted for publication in PLoS Computational Biology, reveal that simple social behavioral rules can drive conformity behaviour in groups, eroding consistent behavioural differences shown by individual animals.

Personality suppression may be a common strategy in group-living animals, and in particular, we should tend to see the behaviors of the most adventurous or shy individuals shifting towards what the majority of the group are doing.

The team modeled the behavior of a small group of animals with differing tendencies while performing risky behaviours when traveling away from a safe home site towards a foraging site. They then compared this to their behaviour while completing the same activity in a group.

The group-aware individuals spent longer in the safe space and moved more quickly to the foraging spot, making the mission less dangerous. Groups are usually made up of individuals who are different to each other in the way that they normally behave—these consistent individual differences are what determines the personality of the individual.

This study was based on fish behaviour. 

When faced with a social task,  researchers found that the fish tend to suppress their own behavior, and instead conform with what other fish in the group are doing.

 If individuals pay attention to other group members, this has an overall impact on the efficiency of the group, and demonstrates that simple social behaviors can result in the suppression of individual personalities.

.This suggests that compromise may lie at the heart of many social behaviors across the animal kingdom.

Sean A. Rands et al, Personality variation is eroded by simple social behaviours in collective foragers, PLoS Computational Biology (2023). DOI: 10.1371/journal.pcbi.1010908. journals.plos.org/ploscompbiol … journal.pcbi.1010908 On bioRxiv: DOI: 10.1101/2022.03.21.485155

Scientists push the boundaries of manipulating light at the submicroscopic level

A team of researchers  has shown light can be moved within a distance which is smaller than its own wavelength—a level of unprecedented precision.

Scientists have demonstrated that a beam of light can not only be confined to a spot which is 50 times smaller than its own wavelength, but that also—in a first of its kind—the spot can be moved by miniscule amounts at the point where the light is confined. The detailed findings of their theoretical study are published in the journal Optica.

Confining and controlling light on ever smaller volumes is one of the defining challenges in modern photonics; the science behind the generation, detection and manipulation of light. How tightly the light is confined determines the limits for the observability of nanoparticles, as well as the intensity and the precision of light-based devices. One example is optical tweezers. These are widely used in laboratories around the world in fields such as that of DNA research. They consist of highly focused laser beams that trap, manipulate and move particles with astounding precision. One of the limitations with standard optical tweezers is that lenses cannot focus beams on lengths much smaller than the laser beam's own wavelength, limiting the achievable precision.

By its nature, light is indeed very difficult to localize on a smaller length scale than its wavelength, a critical threshold known as the Abbe limit. However, using a sophisticated model and numerical simulation, scientists have successfully demonstrated a novel approach to localize and dynamically manipulate light at a sub-wavelength scale.

Erika Cortese et al, Real-space nanophotonic field manipulation using non-perturbative light–matter coupling, Optica (2022). DOI: 10.1364/OPTICA.473085

Asteroid lost 1 million kilograms after collision with DART spacecraft

How to stop bird flu becoming a pandemic

After avian influenza killed a girl in Cambodia last week, fears are rising about the virus’s potential to spark a human pandemic. It’s hard to say whether this will actually happen, says veterinary pathologist Thijs Kuiken. Versions of the H5N1 influenza virus have been circulating in birds for about 25 years, but the discovery of a variant that transmits between mink increases the risk that the virus could start spreading in humans. Scientists say it’s important to keep tracking the disease’s spread.... Because drugs and vaccines against H5N1 are already available, a bird flu pandemic would probably be more manageable than COVID-19.

https://www.nature.com/articles/d41586-023-00591-3?utm_source=Natur...

Researchers have discovered a new type of coexistence between algae and fungi

Researchers  have described the symbiotic relationship between fungi and algae.  The coexistence of algae and corticioid basidiomycetes, which are common in temperate forests, has been given a new name: "alcobiosis." Their work has been published in Scientific Reports.

Years ago, during field trips, researchers were repeatedly puzzled to find a layer of green algae where some of the fungal coatings on wood or bark (so-called corticioid fungi) are disturbed. They discovered that this is a close symbiosis of fungi and algae, not a lichen, though, because the fungus does not depend on its alga for nourishment.

The new term introduced by the researchers for this type of coexistence, "alcobiosis," is formed by letters from the three key words: algae, corticioid fungi and symbiosis.

In the course of several years, the team of researchers gathered a large number of samples and performed DNA sequencing of the algal and fungal partners. They discovered that the symbiosis is very common and occurs in a great many corticioid fungi across the class of agaricomycetes. Individual fungal species are usually faithful to a specific algal species from a range of algae described in various alcobioses.

Ensuing physiological measurements of algal activity in alcobioses confirmed that the algae are alive, active and engage heavily in photosynthesis, which proves that they prosper inside fungal tissue. Alcobioses bear a striking resemblance to lichens, but differ from them in that the fungal partner does not depend on its alga for nourishment.

And so the main unknown still is in what way this symbiosis is beneficial for each of the partners.

But this study shows alcobioses as a widespread phenomenon which includes a large number of algae and fungi.

During their research, the authors also discovered that the spread of alcobioses is aided by small gastropods who often feed on corticioid fungi. Their excrements contain viable cells of algae and fungi who give rise to new alcobiotic coating shortly after. This type of reproduction is similar to lichen "isidia" (i.e., specific lichen thallus structures used in vegetative reproduction). Alcobioses are clearly visible to the naked eye and it is easy to distinguish them from similar fungi that do not form this kind of relationship.

Alcobioses are common in urban areas, too. Lyomyces sambuci, pictured here, is abundant on elder bark. Credit: Institute of Botany, Czech Academy of SciencesJan Vondrák et al, Alcobiosis, an algal-fungal association on the threshold of lichenisation, Scientific Reports (2023). DOI: 10.1038/s41598-023-29384-4. www.nature.com/articles/s41598-023-29384-4

Breathtakingly Beautiful Photo Gives an Astronaut's View of an Aurora

For The First Time Ever, Physicists See Molecules Form Through Quantum Tunneling

Chemistry takes effort. Whether it's by raising the temperature, increasing the odds that compatible atoms will collide in a heated smash-up, or increasing the pressure and squeezing them together, building molecules usually demands a certain cost in energy.

Quantum theory does provide a workaround if you're patient. And a team of researchers from the University of Innsbruck in Austria has finally seen the quantum tunneling in action in a world-first experiment measuring the merger of deuterium ions with hydrogen molecules.

Tunneling is a quirk of the quantum universe that makes it seem like particles can pass through obstacles that are ordinarily too hard to overcome.

In chemistry, this obstacle is the energy required for atoms to bond with one another, or with existing molecules.

Yet theory says that, in extremely rare instances, it's possible for atoms in close proximity to 'tunnel' their way through this energy barrier and connect without any effort.

Quantum mechanics allows particles to break through the energetic barrier due to their quantum mechanical wave properties, and a reaction occurs.

Quantum waves are the ghosts that drive the behaviors of objects like electrons, photons, and even entire groups of atoms, blurring their existence before any observation so they sit not in any one precise place but occupy a continuum of possible positions.

This blurring is insignificant for larger objects like molecules, cats, and galaxies. But as we zoom in on individual subatomic particles, the range of possibilities expands, forcing the location states of various quantum waves to overlap.

When that happens, particles have a slight chance of appearing where they have no business being, tunneling into regions that would otherwise require a great deal of force to enter.

One of those regions for an electron might be within the bonding-zone of a chemical reaction, welding together neighboring atoms and molecules without the boom-crash-crush of heat or pressure.

part1

Understanding the role quantum tunneling plays in the building and rearrangements of molecules could have important ramifications in the calculations of energy release in nuclear reactions, such as those involving hydrogen in stars and fusion reactors here on Earth.

While we've modeled this phenomenon for examples involving reactions between a negatively charged form of deuterium – an isotope of hydrogen containing a neutron – and dihydrogen or H₂, proving the numbers experimentally requires a challenging level of precision.

To accomplish this, Wild and his colleagues cooled negative deuterium ions to a temperature that brought them close to a standstill before introducing a gas made of hydrogen molecules.

Without heat, the deuterium ion was far less likely to have the energy required to force hydrogen molecules into a rearrangement of atoms. Yet it also forced the particles into sitting quietly near one another, giving them more time to bond through tunneling.

In their experiment, scientists give possible reactions in the trap about 15 minutes and then determine the amount of hydrogen ions formed. From their number, they can deduce how often a reaction has occurred.

That figure is just over 5 x 10^-20 reactions per second taking place in each cubic centimeter, or around one tunneling event for around every hundred billion collisions. So not a lot. Though the experiment does back up previous modeling, confirming a benchmark that can be used in predictions elsewhere.

Given tunneling plays a fairly important role in a diverse range of nuclear and chemical reactions, much of which is also likely to occur out in the cold depths of space, getting a precise grip on the factors at play gives us a more solid grounding to base our predictions on.

https://www.nature.com/articles/s41586-023-05727-z

part 2

A Rise in Online Shopping Partially to Blame For Recent Spike in Whale Deaths

Our addiction to online shopping is contributing to the recent spike in whale deaths, The New York Times reports.

Since early December, 23 whales have washed up dead along the East Coast, according to data the National Oceanic and Atmospheric Administration provided to The Times. Their deaths are due to a confluence of factors, both environmental and the result of human interference.

NOAA has been tracking an "unusual mortality event" among the Atlantic Coast humpback whale population since 2016, but the recent spike in whale deaths – which has included humpback whales, minke whales, and North Atlantic right whales, which are critically endangered – prompted the NOAA Fisheries to address the crisis during a call with reporters in January.

Lauren Gaches, the agency's public affairs director, said during the call that climate change is partly to blame for the number of whales washing up dead, because warming oceans are causing the fish they eat to move closer to shore.

"We're seeing populations of many marine species adapting by moving into new areas where conditions are more favorable," Gaches said.

"Changing distributions of prey impact larger marine species that depend on them. This can lead to increased interactions with humans as some whales move closer to near-shore habitats."

Which means as some whales seek out prey, they're moving into the path of cargo ships, which have gotten bigger and more plentiful over the past three years.

Part 1

Boat strikes can be deadly for whale populations all over the world The surge in online shopping that began during the pandemic has led to an increase in cargo ships hauling those goods across the Atlantic to the busy Port of New York and New Jersey. Those ships, larger than they were in the past in order to carry more shipping containers, are also taking new routes in an effort to avoid clogging up shipping lanes like in years past, according to The Times. The Port Authority of New York and New Jersey saw a 27 percent increase in volume last year compared to 2019 levels, and shipping traffic along the East Coast has increased as boats have started making down-and-back trips to retrieve empty shipping containers. While NOAA has proposed speed limits, which could give whales time to move out of the way of oncoming ships, the fact remains that whales are always going to follow their food. "When the whales are in these channels, you have to cross your fingers and hope there are no collisions," Paul Sieswerda, executive director of New York City-based research group Gotham Whale, told The Times. Boat strikes can cause internal injuries from the blunt force trauma, and their propellers can inflict large gashes. Two whales that washed up dead along the Atlantic Coast this month were determined to have been struck by vessels, USA Today reported. This isn't the first time experts have raised the alarm about ships harming whale populations. A year ago, scientists began calling for cargo ships to start rerouting in order to protect endangered blue whales that live off the coast of Sri Lanka. Mediterranean Shipping Company, the largest container line in the world, complied with the request, and animal welfare groups said at the time that if other companies followed, it could reduce ship strikes by 95 percent. This article was originally published by Business Insider.

https://www.sciencealert.com/a-rise-in-online-shopping-partially-to...

Part 2

**

Black Hole Mergers

6174 is known as Kaprekar's constant after the Indian mathematician D. R. Kaprekar. This number is renowned for the following rule:

1. Take any four-digit number, using at least two different digits (leading zeros are allowed).
2. Arrange the digits in descending and then in ascending order to get two four-digit numbers, adding leading zeros if necessary.
3. Subtract the smaller number from the bigger number.
4. Go back to step 2 and repeat.

The above process, known as Kaprekar's routine, will always reach its fixed point, 6174, in at most 7 iterations. Once 6174 is reached, the process will continue yielding 7641 – 1467 = 6174. For example, choose 1459:

9541 – 1459 = 8082

8820 – 0288 = 8532

8532 – 2358 = 6174

7641 – 1467 = 6174

The only four-digit numbers for which Kaprekar's routine does not reach 6174 are repdigits such as 1111, which give the result 0000 after a single iteration. All other four-digit numbers eventually reach 6174 if leading zeros are used to keep the number of digits at 4. For numbers with three identical numbers and a fourth number that is one number higher or lower (such as 2111), it is essential to treat 3-digit numbers with a leading zero; for example: 2111 – 1112 = 0999; 9990 – 999 = 8991; 9981 – 1899 = 8082; 8820 – 288 = 8532; 8532 – 2358 = 6174.

6174 (number) - Wikipedia

Hubble’s Inside The Image: V838

Scientists found a way to generate new neurons in the brain

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A research team  has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them.

Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

Stem cells have the unique ability to continuously produce copies of themselves and give rise to differentiated cells with more specialized functions. Neural stem cells (NSCs) are responsible for building the brain during embryonic development, generating all the cells of the central nervous system, including neurons.

Surprisingly, NSCs persist in certain brain regions even after the brain is fully formed and can make new neurons throughout life. This biological phenomenon, called adult neurogenesis, is important for specific functions such as learning and memory processes. However, in the adult brain, these stem cells become more silent or "dormant" and reduce their capacity for renewal and differentiation.

As a result, neurogenesis decreases significantly with age. Researchers have uncovered a metabolic mechanism by which adult NSCs can emerge from their dormant state and become active again.

They found that mitochondria, the energy-producing organelles within cells, are involved in regulating the level of activation of adult NSCs.

 The mitochondrial pyruvate transporter (MPC), a protein complex discovered eleven years ago, plays a particular role in this regulation. Its activity influences the metabolic options a cell can use. By knowing the metabolic pathways that distinguish active cells from dormant cells, scientists can wake up dormant cells by modifying their mitochondrial metabolism.

Biologists have blocked MPC activity by using chemical inhibitors or by generating mutant mice for the Mpc1gene. Using these pharmacological and genetic approaches, the scientists were able to activate dormant NSCs and thus generate new neurons in the brains of adult and even aged mice.

These results shed new light on the role of cell metabolism in the regulation of neurogenesis. In the long term, these results could lead to potential treatments for conditions such as depression or neurodegenerative diseases.

Francesco Petrelli, Valentina Scandella, Sylvie Montessuit, Nicola Zamboni, Jean-Claude Martinou, Marlen Knobloch. Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells. Science Advances, 2023; 9 (9) DOI: 10.1126/sciadv.add5220

'Plasticosis': The First Disease Caused by Ingested Plastic Was Just Described by Scientists

One of the most plastic-contaminated birds in the whole world is silently suffering from a novel, emerging disease scientists have coined 'plasticosis'.

It's reportedly the first time researchers have ever documented and quantified the pathological effects of ingested plastic in wild animals, and it's got scientists stressing about the health of more than just one species.

The new findings suggest sharp plastic fragments can literally tear some seabirds apart from the inside.

This new  study clearly demonstrates the ability of plastic to directly induce severe, organ-wide scar tissue formation or 'plasticosis' in wild, free-living animals, which is likely to be detrimental to individual health and survival, acccording to reporters. 

When it comes to physical damage caused by ingested plastic, flesh-footed shearwaters (Ardenna carneipes) are the canaries in the coal mine.

Despite the sheer distance from human civilization, many of the chicks hatched on Lord Howe are suffering a slow and sickly death that seems to be all our fault.

Each autumn, gaunt and bedraggled fledglings litter the island's beaches, and for years now, scientists have been trying to figure out why so many of these seabirds are sick and dying.

When researchers examined the carcasses of dozens of dead birds from Lord Howe, they found excessive and irreversible signs of scar tissue in stomach after stomach. The extensive internal scarring is most likely caused by tiny bits of sharp plastic digging into a bird's internal lining over and over. Without the chance to heal, the first chamber of the bird's stomach, called the proventriculus, grows distorted with damage.

Sometime back researchers described about a bird stomach so full of plastic it was "bulging… almost rupturing". The scientists conducting the necropsy counted 202 plastic pieces in total.

That's hardly an exceptional circumstance. Roughly 90 percent of necropsied birds on Lord Howe island have contained plastic in their stomachs.

The consistent scarring and chronic inflammation observed in seabird stomachs filled with plastic has scientists thinking this is a specific fibrotic disease.

They've called it 'plasticosis' to keep in line with other fibrotic diseases, like silicosis and asbestosis, which are also marked by tissue damage from pollutants, except in these cases the damage occurs in the lungs.

lab studies have shown that sharp, ingested macroplastics, around 5 millimeters in size, can block, ulcerate, or perforate digestive tracts, while also reducing feeding behavior. In severe cases, the animal can even starve to death.

The study among shearwaters is the first to show plasticosis occurring among wild animals.

Part 1

In the hardened and inflexible stomach of a plastic-filled shearwater, room for new food is limited and digestion seems to be severely impacted. With so much scar tissue, scientists say the lining of the internal organ is not nearly as good at secreting digestive enzymes or absorbing nutrients.

The resulting loss of nourishment could be a key reason why so many shearwaters on Lord Howe are underweight. Since 2010, their average body mass has plummeted. And in the current study, higher numbers of plastic pieces in a shearwater's stomach were associated with a lower overall body weight.

"The tubular glands, which secrete digestive compounds, are perhaps the best example of the impact of plasticosis.

"When plastic is consumed, these glands get gradually more stunted until they eventually lose their tissue structure entirely at the highest levels of exposure."

The consequences of ingesting plastic may not be the same for all seabird stomachs, or even all animal stomachs, but given the ubiquitous nature of ingested plastic in the marine food web, there's reason to worry about the health effects.

In humans, recent studies have shown people with inflammatory bowel disease (IBD) tend to have elevated levels of microplastics in their feces.

Among 52 participants, greater plastic exposure was closely aligned with the worst IBD symptoms.

That study was only small and does not establish cause and effect, but since microplastics have been found in human blood, placenta, feces, and the deepest parts of our lungs, toxicologists say we need urgent health assessments.

Ingested plastic can not only cause physical damage, it can also provide a way for parasites and microbes to hitchhike into the body. In addition, as plastics degrade, they may leech toxic and persistent chemicals with potentially dangerous health effects.

Part 2

Plasticosis may be the first wildlife disease connected to plastics, but it may not be the last.

https://www.sciencedirect.com/science/article/pii/S0304389423003722...

Part 3

New treatment of autoimmune diseases revealed in new study

Scientists  have revealed a chemical compound that could be used for the treatment of various autoimmune diseases like multiple sclerosis and rheumatoid arthritis. These diseases occur when the body's immune response goes awry. The immune system, which normally attacks pathogens and infections, instead attacks healthy cells and tissues. For the millions of people who suffer from autoimmune diseases worldwide, the result can be debilitating—rheumatoid arthritis causes excessive joint pain, while multiple sclerosis can disable one's brain and spinal cord function.

The research focused on T helper 17 cells, or Th17 cells. Th17 cells are a type of T cell—a group of cells, which form major parts of the immune system. These cells, which exist in high numbers in our guts, evolved to help us fight invasive pathogens but, sometimes, they're overactivated and mistake normal, healthy tissue as pathogens, resulting in autoimmunity. The generation of Th17 cells requires glycolysis, a metabolic process in which glucose is broken down and converted to energy to support the metabolic needs of cells. Glycolysis is essential for the growth of not only Th17 cells but also a variety of cells in our body.

 Excessive glycolysis seems to suppress Th17 cell activity. So scientists hypothesized that molecules produced during glycolysis may inhibit the cells.

Enter phosphoenolpyruvate, or PEP for short. This chemical compound  is a metabolite produced when glucose is converted to energy. Since it is part of such an important process, PEP is generated every day in our bodies. The researchers found that treatment with PEP can inhibit the maturation of TH17 cells, leading to resolution of inflammatory response.

The research led to a protein called JunB, which is essential for the maturation of Th17 cells. JunB promotes Th17 maturation by binding to a set of specific genes. The researchers found that PEP treatment inhibits the generation of Th17 cells by blocking JunB activity.

Armed with this knowledge, the researchers went on to treat mice that had neuroinflammation caused by autoimmunity with PEP. This disease is very similar to multiple sclerosis and these mice showed positive signs of recovery. The scientists have now filed a patent to continue with this research.

Tsung-Yen Huang et al, Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity, Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112205

In the past, researchers who were interested in developing a treatment for autoimmune diseases, often looked at inhibiting glycolysis and thus Th17 cells. But glycolysis is essential to various types of cells in the body and inhibiting it could have significant side-effects. PEP has the potential to be used as a treatment without resulting in such side-effects.

Trapping and killing superbugs with novel peptide 'nanonets'

Scientists have developed synthetic peptide nanonets for treating infections by bacteria strains resistant to last-resort antibiotics.

In nature, trap-and-kill is a common immune defense mechanism employed by various species, including humans. In response to the presence of pathogens, peptides are released from host cells and they promptly self-assemble in solution to form cross-linked nanonets, which then entrap the bacteria and render them more vulnerable to antimicrobial components.

Several research groups have explored synthetic biomimetics of nanonets as an avenue for addressing the global healthcare challenge of widespread antibiotic resistance. However, most prominent studies in the field only yielded disjointed short nanofibrils restricted to the bacterial surfaces and are incapable of physically immobilizing the bacteria. Additionally, these designs were lacking in control over the initiation of the self-assembly process.

International Women's Day 2023 - "DigitALL: Innovation & Technology for Gender Equality"

UN forges historic deal to protect ocean life: what researchers think

Nations forge a historic High Seas Treaty

After two decades of talks and a marathon 38-hour final session of negotiations, United Nations member countries have agreed on a framework to protect marine biodiversity and provide oversight of international waters. The High Seas Treaty will cover waters outside countries’ national .... The treaty establishes a mechanism to designate marine protected areas and creates several groups — including a scientific and technical body — to oversee regulations covering issues including marine genetic resources. “We’re ecstatic,” says Kristina Gjerde, who researches marine environmental law. “This long-awaited treaty contains many of the vital things we need to safeguard our oceans.”

Enzyme that turns air into electricity discovered, providing a new clean source of energy

Scientists have discovered an enzyme that converts air into energy. The finding, published recently in the journal Nature, reveals that this enzyme uses the low amounts of the hydrogen in the atmosphere to create an electrical current. This finding opens the way to create devices that literally make energy from thin air.

The researchers produced and analyzed a hydrogen-consuming enzyme from a common soil bacterium. Recent work by the team has shown that many bacteria use hydrogen from the atmosphere as an energy source in nutrient-poor environments. Bacteria can use the trace hydrogen in the air as a source of energy to help them grow and survive, including in Antarctic soils, volcanic craters, and the deep ocean. But this new discovery made it clear that this enzyme used by the bacteria can produce electricity from air.

The researchers extracted the enzyme responsible for using atmospheric hydrogen from a bacterium called Mycobacterium smegmatis. They showed that this enzyme, called Huc, turns hydrogen gas into an electric current. Huc is extraordinarily efficient. Unlike all other known enzymes and chemical catalysts, it even consumes hydrogen below atmospheric levels—as little as 0.00005% of the air we breathe.

The researchers used several cutting-edge methods to reveal the molecular blueprint of atmospheric hydrogen oxidation. They used advanced microscopy (cryo-EM) to determine its atomic structure and electrical pathways, pushing boundaries to produce the most resolved enzyme structure reported by this method to date. They also used a technique called electrochemistry to demonstrate the purified enzyme creates electricity at minute hydrogen concentrations.

Laboratory work performed by researchers shows that it is possible to store purified Huc for long periods. It is astonishingly stable. It is possible to freeze the enzyme or heat it to 80 degrees celsius, and it retains its power to generate energy. This reflects that this enzyme helps bacteria to survive in the most extreme environments. 

Huc is a "natural battery" that produces a sustained electrical current from air or added hydrogen. While this research is at an early stage, the discovery of Huc has considerable potential to develop small air-powered devices, for example as an alternative to solar-powered devices.

The bacteria that produce enzymes like Huc are common and can be grown in large quantities, meaning we have access to a sustainable source of the enzyme.

 Chris Greening, Structural basis for bacterial energy extraction from atmospheric hydrogen, Nature (2023). DOI: 10.1038/s41586-023-05781-7. www.nature.com/articles/s41586-023-05781-7

A spontaneous gravity prior: newborn chicks prefer stimuli that move against gravity

Heavy alcohol consumption increases brain inflammation and influences decision making

For people with alcohol use disorder (AUD), there is a constant, vicious cycle between changes to the brain and changes to behavior. AUD can alter signaling pathways in the brain; in turn, those changes can exacerbate drinking.

Now, scientists  have uncovered new details about the immune system's role in this cycle. They reported in the journal Brain, Behavior and Immunity on Feb. 28, 2023, that the immune signaling molecule interleukin 1β (IL-1β) is present at higher levels in the brains of mice with alcohol dependence. In addition, the IL-1β pathway takes on a different role in these animals, causing inflammation in critical areas of the brain known to be involved in decision-making.

These inflammatory changes to the brain could explain some of the risky decision-making and impulsivity we see in people with alcohol use disorder.

In addition, these findings are incredibly exciting because they suggest a potential way to treat alcohol use disorder with existing anti-inflammatory drugs targeting the IL-1β pathway.

AUD is characterized by uncontrolled and compulsive drinking, and it encompasses a range of conditions including alcohol abuse, dependence and binge drinking. Researchers have previously discovered numerous links between the immune system and AUD—many of them centered around IL-1β. People with certain mutations in the gene that codes for the IL-1β molecule, for instance, are more prone to developing AUD. In addition, autopsies of people who had AUD have found higher levels of IL-1β in the brain.

In the new study, researchers compared alcohol-dependent mice with animals drinking moderate or no alcohol at all. They discovered that the alcohol-dependent group had about twice as much IL-1β in the medial prefrontal cortex (mPFC), a part of the brain that plays a role in regulating emotions and behaviors.

The research team then went on to show that IL-1β signaling in the alcohol-dependent group was not only increased, but also fundamentally different. In mice that had not been exposed to alcohol, as well as in mice that had drunk moderate amounts of alcohol, IL-1β activated an anti-inflammatory signaling pathway. In turn, this lowered levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), a signaling molecule known to regulate neural activity in the brain.

However, in alcohol-dependent mice, IL-1β instead activated pro-inflammatory signaling and boosted levels of GABA, likely contributing to some of the changes in brain activity associated with AUD. Notably, these changes in IL-1β signaling in the alcohol-dependent mice persisted even during alcohol withdrawal.

F.P. Varodayan, A.R. Pahng, T.D. Davis, P. Gandhi, M. Bajo, M.Q. Steinman, W.B. Kiosses, Y.A. Blednov, M.D. Burkart, S. Edwards, A.J. Roberts, M. Roberto. Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice. Brain, Behavior, and Immunity, 2023; 110: 125 DOI: 10.1016/j.bbi.2023.02.020

Low-dose radiation linked to increased lifetime risk of heart disease

Exposure to low doses of ionizing radiation is associated with a modestly increased excess risk of heart disease, finds an analysis of the latest evidence published by The BMJ recently.

The researchers say these findings "have implications for patients who undergo radiation exposure as part of their medical care, as well as policy makers involved in managing radiation risks to radiation workers and the public." A linked editorial suggests that these risks "should now be carefully considered in protection against radiation in medicine and elsewhere."

It's well recognized that exposure to high dose radiation can damage the heart, but firm evidence linking low dose radiation to heart disease (e.g., scatter radiation dose from radiotherapy or working in the nuclear industry) is less clear.

To address this knowledge gap, an international team of researchers examined scientific databases for studies evaluating links between a range of cardiovascular diseases and exposure to radiation (mostly radiotherapy and occupational exposures).

They excluded uninformative datasets or those largely duplicating others, leaving 93 studies, published mainly during the past decade, suitable for analysis. These studies covered a broad range of doses, brief and prolonged exposures, and evaluated frequency (incidence) and mortality of various types of vascular diseases.

After taking account of other important factors, such as age at exposure, the researchers found consistent evidence for a dose dependent increase in cardiovascular risks across a broad range of radiation doses.

For example, the relative risk per gray (Gy) increased for all cardiovascular disease and for specific types of cardiovascular disease, and there was a higher relative risk per dose unit at lower dose ranges (less than 0.1 Gy), and also for lower dose rates (multiple exposures over hours to years).

At a population level, excess absolute risks ranged from 2.33% per Gy for a current England and Wales population to 3.66% per Gy for Germany, largely reflecting the underlying rates of cardiovascular disease mortality in these populations.

This equates to a modest but significantly increased excess lifetime risk of 2.3-3.9 cardiovascular deaths per 100 persons exposed to one Gy of radiation, explain the authors.

Ionising radiation and cardiovascular disease: systematic review and meta-analysis, The BMJ (2023). DOI: 10.1136/bmj-2022-072924

Researchers discover how too much oxygen damages cells and tissues

Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in people and animals, particularly if it's in excess of the body's oxygen needs. Until now, however, scientists have mostly speculated about the mechanisms behind this phenomenon, known as oxygen toxicity, or hyperoxia.

Now, researchers at Gladstone Institutes have discovered how excess  oxygen changes a handful of proteins in our cells that contain iron and sulfur—a chemical process similar to the rusting of iron. In turn, those "rusty" proteins trigger a cascade of events that damage cells and tissues. The findings, published in the journal Molecular Cell, have implications for conditions such as heart attacks and sleep apnea.

At high levels, oxygen is toxic to every form of life, from bacteria and plants to animals and people. Of course, not enough oxygen is also fatal; there's an intermediate, "Goldilocks" amount under which most life on Earth thrives—not too much and not too little.

While clinicians have long studied the details of how oxygen shortage impacts cells and tissues (for example, in heart attacks and strokes), the effects of excess oxygen have been relatively understudied.

Studies have recently revealed, for instance, that breathing too much supplemental oxygen might be detrimental to heart attack  patients and premature infants. Similarly, in obstructive sleep apnea,  the sudden bursts of oxygen that follow pauses in breathing have been shown to be a key component of how the disorder increases patients' risks of chronic health problems.

Part 1

So researchers now turned to the genome editing technology CRISPR to test the roles of a variety of genes in hyperoxia.

Using CRISPR, the researchers removed, one at a time, more than 20,000 different genes from human cells grown in the lab and then compared the growth of each group of cells at 21 percent oxygen and 50 percent oxygen.

This kind of unbiased screen let researchers probe the contributions of thousands of different pathways in hyperoxia rather than just focusing on those we already suspected might be involved.

Four molecular pathways stood out in the screen as being involved in the effects of hyperoxia. They related to diverse cellular functions including the repair of damaged DNA, the production of new DNA building blocks, and the generation of cellular energy.

It took some molecular sleuthing to discover that each pathway had a critical protein that contained iron atoms connected to sulfur atoms—so-called "iron-sulfur clusters"—in its molecular structure.

The researchers went on to show that in as little as 30 percent oxygen, the iron-sulfur clusters in the four proteins become oxidized—they chemically react with oxygen atoms—and that change causes the proteins to degrade. As a result, cells stop functioning correctly and consume even less oxygen, causing a further increase in oxygen levels in the surrounding tissues.

One important thing found in this work is that hyperoxia is not impacting cells and tissues solely through reactive oxygen species, as many had assumed. That means the use of antioxidants—which can combat reactive oxygen species to some degree—is unlikely to be sufficient to prevent oxygen toxicity.

 Alan H. Baik et al, Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes, Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.02.013

Part 2

Bacterial enzyme traps and breaks down PFAS molecules

Highly nondegradable chemicals such as PFAS and pesticides can have useful properties in some situations, but are extremely difficult for nature to remove afterwards. Now researchers have found that certain bacteria use an enzyme that acts as a molecular nutcracker to crush the harmful substances.

All cells contain a large number of enzymes, each of which functions as a small machine that carries out a specific task. Inside E. coli bacteria, researchers have found an enzyme, C-P lyase, that enables the microbe to degrade highly stable chemicals. By rapidly freezing purified samples of the enzyme, the researchers have succeeded in capturing the molecular nutcracker in two different states that represent an open and closed form, respectively. The results show that the bacterium uses the energy from ATP, the cellular energy source, to both open and close the nutcracker.

Two similar, ATP-consuming modules, which are mostly known from transport proteins, have been put together to be able to open and close the enzyme.

The results, which have recently been published in the journal, Nature Communications, are expected to be useful in developing dedicated strains of bacteria that survive by breaking down the difficult substances and therefore potentially can be of great importance for the future use of pesticides in agriculture.

Søren K. Amstrup et al, Structural remodelling of the carbon–phosphorus lyase machinery by a dual ABC ATPase, Nature Communications (2023). DOI: 10.1038/s41467-023-36604-y

**

Scientists harness power, precision of RNA to make mutations invisible

Scientists have discovered a new way to suppress mutations that lead to a wide range of genetic disorders.

A study recently published in the journal Molecular Cell describes a strategy that co-opts a normal RNA modification process within cells to transform disease genes into normal genes that produce healthy proteins. The findings are significant because they may ultimately help researchers alter the course of devastating disorders such as cystic fibrosis, muscular dystrophy and many forms of cancer.

About 15% of mutations that lead to genetic diseases are called nonsense mutations. Aptly named, nonsense mutations occur when an mRNA molecule contains an early "stop" signal. When the mRNA takes genetic instructions from DNA to create a protein, this early stop sign orders the cell to stop reading the instructions partway through the process. This results in the creation of an incomplete protein that can lead to disease.

A team of researchers  designed an artificial guide RNA—a piece of RNA that can modify other types of RNA—to target mRNA molecules that contain early stop signals (also called premature termination codons). Guide RNAs are a natural mechanism that cells use all the time; This  team altered this already existing process.

Like DNA, RNA is made up of molecular building blocks that are represented by the letters A (adenine), G (guanine), U (uracil), and C (cytosine). Premature termination codons always have the building block U in the first position (for example, UAG, UAA or UGA). The team's artificial guide RNA was designed to modify the U in the first position, changing the molecular makeup of the targeted mRNA so that the stop signal is no longer—or less well—recognized by the cell.

Researchers tested the artificial guide RNA in yeast cells and in human disease cells (derived from cystic fibrosis and neurofibromatosis patients). In both cases, they found the action of the artificial guide RNA rendered the premature termination codon (stop sign) invisible, allowing cells to read the genetic instructions all the way through and create full-length, functional proteins.

They also discovered that the guide RNA suppressed another mechanism in the cell known as nonsense-mediated mRNA decay or NMD. One of the major surveillance systems in the body, NMD targets and eliminates mRNAs with premature termination codons, so no protein is produced. Curbing NMD is another way the artificial guide RNA ensured that a significant amount of mRNA was present in the cell, and that the genetic instructions carried by the targeted mRNAs were read all the way through and translated into complete proteins.

Hironori Adachi et al, Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes, Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.01.009

In the world's smallest ball game, scientists throw and catch singl...

In many baseball-obsessed countries like Korea, Japan and the United States, with spring months comes the start of the season and quite a few balls flying through the air. But it's not just balls that can be thrown. On the tiniest field imaginable, scientists have now shown they can also throw and catch individual atoms using light.

This amazing feat was achieved with optical traps, which use a highly focused laser beam to hold and move tiny objects. Although optical traps have been used to move individual atoms before, this is the first time an atom has been released from a trap—or thrown—and then caught by another trap.

 Jaewook Ahn et al, Optical tweezers throw and catch single atoms, Optica (2023). DOI: 10.1364/OPTICA.480535

The mice with two dads: scientists create eggs from male cells

How wildfires shred the ozone layer

Huge wildfires that raged across Australia in 2019–20 unleashed chemicals that chewed through the ozone layer. The wildfire smoke combined with harmless remnants of now-banned chlorinated compounds, reactivating their ozone-eating form — a reaction that doesn’t usually happen in the warm air away from the poles. More-frequent wildfires resulting from climate change could expand ..., which protects Earth from harmful ultraviolet rays.

https://www.nature.com/articles/d41586-023-00687-w?utm_source=Natur...

https://www.nature.com/articles/s41586-022-05683-0.epdf?sharing_tok...

Ancient dormant viruses found in permafrost, once revived, can infect 

A team of climate scientists has found that ancient viruses dormant for tens of thousands of years in permafrost can infect modern amoeba when they are revived. For their study, reported on the open-access site Viruses, the group collected several giant virus specimens from permafrost in Siberia and tested them to see if they could still infect modern creatures.

Prior research has shown that permafrost—frozen soil—is an excellent preservative. Many carcasses of frozen extinct animals have been extracted from permafrost in the Northern Hemisphere. Prior research has also shown that plant seeds lying dormant in permafrost can be coaxed to grow once revived. And there is evidence suggesting that viruses and bacteria trapped in permafrost could infect hosts if revived. In this new effort, the researchers tested this theory.

The effort by the research team followed up on prior work in 2014 that showed a 30,000-year-old virus could be revived—and that it could be infectious. The team followed up on that effort by reviving a different virus in 2015 and allowing it to infect an amoeba. In this new effort, the team collected several virus specimens from multiple permafrost sites across Siberia for lab testing. For safety reasons, the research team collects only so-called giant viruses and only those that can infect amoeba, not humans or any other creature. In reviving the virus samples, the team found that they were still capable of infecting amoeba. They also found, via radiocarbon dating of the permafrost in which they were found, that the viruses had been in a dormant state for between 27,000 and 48,500 years.

The researchers suggest their findings hint at a much bigger problem—as the planet warms and the permafrost melts, there is a chance of viruses emerging that are capable of infecting humans. Such a threat is not science fiction, they note—prior researchers found influenza viruses in a lung sample of a woman who had died in Alaska during the flu pandemic of 1918. And another team found a virus related to smallpox in a mummified woman found in Siberia—she had been there for 300 years.

Jean-Marie Alempic et al, An Update on Eukaryotic Viruses Revived from Ancient Permafrost, Viruses (2023). DOI: 10.3390/v15020564

You're stuck with your same old genome, but corals aren't

Some corals live to be hundreds, and even thousands, of years old. They were born with genes that were successful back in their parent's generation, so how can these old corals still be successful now? Especially in a changing climate? It's possible that the generation and the filtering of mutations that occur in different parts of a big coral act as a proving ground for adaptive genetics for the future. A new study shows a novel way that some very ancient animals might be surviving.

You got your entire set of genes—good or bad—from your parents, and those are the only genes you will have for your entire life. Those genes are also the only ones you will pass along to your children. Of course, there are a few exceptions—like mutations that happen in sperm or egg cells that you might pass along to the next generation. And a growing chorus of technologies is poised to alter harmful mutations in human genes that make life difficult, such as recent success in altering the genes in lung cells that cause cystic fibrosis.

Nearly every animal must make a living with a set of genes that remains virtually unchanged during their lifetime, but a recent study of tropical reef building corals shows something different. These very long-lived animals are constantly changing and testing their genes—and some of these changes make it into the next generation. In this way a centuries-old coral might be a cauldron of genetic innovation, and it might help prepare them for climate change.

Elora H. López-Nandam et al, Mutations in coral soma and sperm imply lifelong stem cell renewal and cell lineage selection, Proceedings of the Royal Society B: Biological Sciences (2023). DOI: 10.1098/rspb.2022.1766

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