Scientists engineer human antibodies that could neutralize black widow toxin

There are various types of widow spiders, including black, red, and brown varieties in North and South America, the Australian redback spider, and several button spider species that inhabit South Africa. In Europe, Latrodectus tredecimguttatus—the European black widow—inhabits the Mediterranean region, but recently and due to the changing climate, the widows have been expanding their habitat.

Widow spiders' bites can cause latrodectism, a disease where the spider's venom, a neurotoxin known as alpha-latrotoxin, attacks the nervous system and causes symptoms like severe pain, hypertension, headache, and nausea. Black widow bites can be treated with antibodies derived from horses, but to make treatment safer for patients, researchers have set out to develop fully human antibodies.

For the first time, they presented human antibodies which show neutralization of black widow spider venom in a cell-based assay. This is the first step to replace the horse sera that are still used to treat the severe symptoms after a black widow spider bite.

Many patients bitten by black widows aren't treated altogether because the antivenom is made from proteins derived from horses which are foreign to the human body and can cause undesirable side effects. These include serum sickness, a reaction to proteins in antisera derived from non-human animal sources, and serious allergic reaction. The available antivenom is also an undefined mix of antibodies that varies from batch to batch. Despite these shortcomings, this antivenom is the most efficient treatment option available right now.

Scientists set out to replace horse sera with recombinant human antibodies to get a better product for the patients and to avoid the use of horses for serum production. 

To do so, the scientists used an in vitro method called antibody phage display.

This approach uses extremely diverse gene collections of more than 10 billion different antibodies. From this large diversity of antibodies, phage display can fish out antibodies which can bind the desired target, in this case the toxin.

Antibodies engineered in such a way can be reproduced in the same quality again and again because the DNA sequence of the human antibody is known. They also could also improve animal welfare because horses do not need to be immunized and bled to produce black window anti-toxins.

Human antibodies neutralizing the alpha-latrotoxin of the European black widow, Frontiers in Immunology (2024). DOI: 10.3389/fimmu.2024.1407398

New theory describes how waves carry information from surroundings

Waves pick up information from their environment through which they propagate. A theory of information carried by waves has now been developed at TU Wien—with astonishing results that can be utilized for technical applications.

Ultrasound is used to analyze the body, radar systems to study airspace or seismic waves to study the interior of our planet. Many areas of research are dealing with waves that are deflected, scattered or reflected by their surroundings. As a result, these waves carry a certain amount of information about their environment, and this information must then be extracted as comprehensively and precisely as possible.

Searching for the best way to do this has been the subject of research around the world for many years. Researchers have now succeeded in describing the information carried by a wave about its environment with mathematical precision. This has made it possible to show how waves pick up information about an object and then transport it to a measuring device.

This can now be used to generate customized waves to extract the maximum amount of information from the environment—for more precise imaging processes, for example. This theory was confirmed with microwave experiments. The results were published in the journal Nature Physics.

Jakob Hüpfl et al, Continuity equation for the flow of Fisher information in wave scattering, Nature Physics (2024). DOI: 10.1038/s41567-024-02519-8

How spaceflight disrupts a person’s biology
Just a few days in orbit can cause immune-cell disruption, dehydration and cloudy thinking — but most of these conditions revert to normal soon after travellers return to Earth, according to the largest catalogue of data detailing the impacts of space travel on the human body. The reports aim to chart how spaceflight affects space tourists, who have a wider variety of health histories than trained astronauts. This is the beginning of precision medicine for spaceflight.

https://www.nature.com/articles/s41586-024-07639-y.epdf?sharing_tok...

https://www.nature.com/articles/s41586-024-07648-x.epdf?sharing_tok...

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A glass that builds and heals itself

A glass that builds and heals itself

Drug that ‘melts away’ tumours hailed as ‘gamechanger’ for some bowel cancer patients
Pembrolizumab triples chance of survival for the 10-15% of patients with the 'right genetic makeup', study finds
A “gamechanger” immunotherapy drug that “melts away” tumours dramatically increases the chances of curing some bowel cancers and may even replace the need for surgery, doctors have said.

Pembrolizumab targets and blocks a specific protein on the surface of immune cells that then seek out and destroy cancer cells.

Giving the drug before surgery instead of chemotherapy led to a huge increase in patients being declared cancer-free, a clinical trial found. The results were presented at the annual meeting of the American Society of Clinical Oncology (ASCO), the world’s largest cancer conference.

https://meetings.asco.org/abstracts-presentations/234190?utm_source...

Imaging techniques peek into the placenta
Researchers are finding ways to monitor an understudied human organ: the placenta. Defects in the placenta might be responsible for many miscarriages and stillbirths. The mysterious organ has proven difficult to study, largely because of the risks to pregnant women and their historical exclusion from clinical trials. Magnetic resonance imaging and ultrasounds help researchers to visualize the placenta and its blood flow in a non-invasive way, and spot potential problems before they lead to pregnancy loss. But progress remains slow. We’re dealing with a paradigm change, and there’s a lot of resistance to changing the paradigm now.  

https://www.theatlantic.com/health/archive/2024/06/placenta-stillbi...

Chronic Insomnia Linked to Ultra-Processed Foods

Permanent gene edits to tardigrades help shed light on their amazing resilience

Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. And we need to know the genetic basis of this resilience to use the knowledge. 

For the first time, researchers successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The work has been published in PLoS Genetics.

The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.

If you've heard about tardigrades, then you've no doubt heard about their uncommon abilities to survive things like extreme heat, cold, drought, and even the vacuum of space, which different members of the species possess. So naturally, they attract researchers keen to explore these novelties, not just out of curiosity, but also to look at what applications might one day be possible if we learn their secrets.

To understand tardigrades' superpowers, we first need to understand the way their genes function. 

Researchers have developed a method to edit genes—adding, removing or overwriting them—like you would do on computer data, in a very tolerant species of tardigrade, Ramazzottius varieornatus. This can now allow researchers to study tardigrade genetic traits as they might more established lab-based animals, such as fruit flies or nematodes.

The team used a recently-developed technique called direct parental CRISPR (DIPA-CRISPR), based on the now-famous CRISPR gene-editing technique, which can serve as a genetic scalpel to cut and modify specific genes more efficiently than ever before. DIPA-CRISPR has the advantage of being able to affect the genome of a target organism's offspring and had previously been shown to work on insects, but this is the first time it's been used on the non-insect organisms that include tardigrades.

Single-step generation of homozygous knockout/knock-in individuals in an extremotolerant parthenogenetic tardigrade using DIPA-CRISPR, PLoS Genetics (2024). DOI: 10.1371/journal.pgen.1011298

Why many lung cancer patients who have never smoked have worse outcomes
The reason targeted treatment for non-small cell lung cancer fails to work for some patients, particularly those who have never smoked, has been discovered by researchers.
The study, published in Nature Communications, shows that lung cancer cells with two particular genetic mutations are more likely to double their genome, which helps them to withstand treatment and develop resistance to it.
The most common genetic mutation found in NSCLC is in the epidermal growth factor receptor gene (EGFR), which enables cancer cells to grow faster. It is found in 10-15 % of patients who have never smoked.
Survival rates vary depending on how advanced the cancer is, with only around a third of patients with Stage IV NSCLC and an EGFR mutation surviving for up to three years.
Lung cancer treatments that target this mutation, known as EGFR inhibitors, have been available for over 15 years. However, while some patients see their cancer tumors shrink with EGFR inhibitors, other patients, particularly those with an additional mutation in the p53 gene (which plays a role in tumor suppression), fail to respond and experience far worse survival rates.
Part 1

To find the answer, the researchers re-analyzed data from trials of the newest EGFR inhibitor, osimertinib, developed by AstraZeneca. They looked at baseline scans and first follow-up scans taken a few months into treatment for patients with either EGFR-only or with EGFR and p53 mutations.

The team compared every tumor on the scans, far more than were measured in the original trial. They found that for patients with just the EGFR mutations, all tumors got smaller in response to treatment. But for patients with both mutations, while some tumors had shrunk, others had grown, providing evidence of rapid drug resistance. This pattern of response, when some but not all areas of a cancer are shrinking in response to a drug treatment within an individual patient, is known as a "mixed response" and is a challenge for oncologists caring for patients with cancer.
To investigate why some tumors in these patients might be more prone to drug resistance, the team then studied a mouse model with both the EGFR and p53 mutation. They found that within resistant tumors in these mice, far more cancer cells had doubled their genome, giving them extra copies of all their chromosomes.

The researchers then treated lung cancer cells in the lab, some with just the single EGFR mutation and some with both mutations, with an EGFR inhibitor. They found that within five weeks of exposure to the drug, a significantly higher percentage of cells with both the double mutation and double genomes had multiplied into new drug-resistant cells.
Once we can identify patients with both EGFR and p53 mutations whose tumors display whole genome doubling, we can then treat these patients in a more selective way now.

 Sebastijan Hobor, Heterogeneous responses to EGFR tyrosine kinase inhibition in non-small cell lung cancer result from chromosomal instability facilitated by whole genome doubling and TP53 co-mutation, Nature Communications (2024). DOI: 10.1038/s41467-024-47606-9

Part 2

New study shows outdoor recreation noise affects wildlife behaviour and habitat use

We may go to the woods seeking peace and quiet, but are we taking our noise with us? A study published in the journal, Current Biology, led by scientists from the USDA Forest Service Rocky Mountain Research Station indicates that the answer is yes—and that this noise can trigger a fear response, as if escaping from predators.

This new science calls into question whether otherwise high-quality habitat truly provides refugia for wildlife when recreationists are present and underscores the challenges land managers face in balancing outdoor recreational opportunities with wildlife conservation.

This new study is the first to quantify responses to human-produced recreation noise based on recreation type, group size, group vocalizations, and wildlife species. Information like this can help managers balance recreation opportunities with wildlife management, which is critical as outdoor recreation continues to grow in popularity.

The study was conducted in the Bridger-Teton National Forest, Wyoming. Researchers used a novel experimental setup to isolate and investigate the effects of recreation noise on several mammal species.

Scientists placed wildlife cameras and speakers on wildlife trails throughout the study areas. Animals that entered study areas triggered speakers to broadcast different types of noise, and nearby cameras captured video of the animals' behavioral responses to the sounds.

The broadcasted noises were associated with different types of recreation such as hiking, mountain biking, and off highway vehicle use, as well as different-sized groups, and both with and without human voices. This setup allowed the researchers to observe both the immediate responses in animal behavior to recreation noise and changes in wildlife presence at the study areas.

Part 1

Scientists analyzed the video footage and compared how wildlife responded to various recreation noises as well as nature sounds and periods without any broadcasted noise. Key findings from the study:

• Increased fleeing and vigilance: Wildlife were 3.1 to 4.7 times more likely to flee and exhibited vigilance behaviors for 2.2 to 3.0 times longer when exposed to recreation noise compared to natural sounds or no noise.
• Reduced wildlife presence: The local relative abundance of wildlife was observed to be 1.5 times lower in the week following the deployment of recreation noise.
• Impact of group size and activity type: Larger groups, particularly vocal hikers and mountain bikers, caused the highest probability of wildlife flight, with 6 to 8 times greater likelihood.
• Species sensitivity: Elk and black bears were the most sensitive to recreation noise, fleeing from the recreationist sounds most consistently, while large carnivores were the least affected.

Outdoor recreation activities like hiking, mountain biking, and motorized vehicle use are steadily increasing, both in numbers of people recreating and number of days spent participating in these activities.

Noise from recreation can carry far beyond a trail system, so understanding how noise alone can affect wildlife is important for management.

Experimental recreationist noise alters behavior and space use of wildlife, Current Biology (2024). DOI: 10.1016/j.cub.2024.05.030. www.cell.com/current-biology/f … 0960-9822(24)00673-0

Part 2

Confronting trauma alleviates chronic pain among older veterans, study shows

Our soap operas and movies say as some  people cannot bear pain from trauma, it is better to hide things from them.

However, science has a different view on this. A new study found chronic pain among older adults could be significantly reduced through a newly developed psychotherapy that works by confronting past trauma and stress-related emotions that can exacerbate pain symptoms.

Published in JAMA Network Open on June 13, the study compared the newer therapy, known as emotional awareness and expression therapy, or EAET, to traditional cognitive behavioral therapy, or CBT, in treating chronic pain as well as mental health symptoms such as depression, anxiety and post-traumatic stress disorder symptoms among older veterans.

The study found that 63% of veterans who underwent EAET reported at least a 30% reduction in pain—a clinically significant reduction—after treatment compared to only 17% of veterans who underwent cognitive behavioral therapy.

Pain reduction was sustained among 41% of EAET participants six months after treatment compared to 14% of CBT patients. Additionally, EAET patients reported greater benefits for addressing anxiety, depression, PTSD and life satisfaction.

Most people with chronic pain don't consider psychotherapy at all. They're thinking along the lines of medications, injections, sometimes surgery or bodily treatments like physical therapy.
Psychotherapy is an evidence-based treatment for chronic pain. What this study adds is that the type of psychotherapy matters.
EAET has one primary intervention: experiencing, expressing and releasing emotions.
Developed in the 2010s, the therapy aims to show patients that the brain's perception of pain is strongly influenced by stress-related emotions. Patients are asked to focus on a stressful interaction, from anything as mundane as being cut off by a driver to severe traumas .
The purpose is to have patients experience these emotions both in mind and in body. The patients then work to confront these emotions, express their reactions and ultimately to let go.
If there is a hurt or stressor people have a series of normal, natural emotional reactions. There might be anger, guilt and sadness. Because these feelings are painful, people often avoid them, but EAET helps people face difficult feelings with honesty and self-compassion. In therapy, they can release anger, pain and guilt that they've been carrying and are left with self-compassion in the end.

Emotional Awareness and Expression Therapy or Cognitive Behavioral Therapy for Chronic Pain in Older Adults: A Randomized Clinical Trial, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.15842. jamanetwork.com/journals/jaman … tworkopen.2024.15842

Part 2

Discovery of antimicrobial peptides in the global microbiome with machine learning
800,000 possible new antibiotics
Researchers used a machine learning approach to survey tens of thousands of genomes found in soils, oceans and the human gut, and in microbial databases. They identified over 800,000 potential antimicrobial peptides (AMPs) — small molecules used by organisms to fight off microbial infections — most of which had not been seen before. As a proof of concept, researchers took 100 of these peptides and tested them against 11 pathogens in the lab. Of these, 63 peptides could halt the growth of at least one pathogen and a smaller number could fight off infections in mice. The 800,000 AMPs are now housed in an open-access resource for antibiotic discovery.

https://www.cell.com/cell/fulltext/S0092-8674(24)00522-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424005221%3Fshowall%3Dtrue

• Machine learning predicts nearly 1 million new antibiotics in the global microbiome
• •
  Out of 100 tested peptides, 79 were active in vitro; 63 of these targeted pathogens
• •
  Some peptides may originate from longer sequences through genomic fragmentation
• •
  The AMPSphere is an open-access resource to accelerate antibiotic discovery

Dietary Supplement Found to Reduce Aggression by Up to 28%

Third Form of Life Makes Energy in 'Remarkable' Ways, Scientists Discover
As the world turns to green hydrogen and other renewable energy sources, scientists have discovered that archaea – the third form of life after bacteria and eukaryotes – have been making energy using hydrogen gas and 'ultraminimal' enzymes for billions of years.
Specifically, the international team of researchers discovered that at least nine phyla of archaea, a domain of single-celled organisms lacking internal membrane-bound structures, produce hydrogen gas using enzymes thought to only exist in the other two forms of life.

Archaea, they realized, not only have the smallest hydrogen-using enzymes compared to bacteria and eukaryotes, but their enzymes for consuming and producing hydrogen are also the most complex characterized so far.
Small and mighty, these enzymes have seemingly allowed archaea to survive and thrive in some of Earth's most hostile environments where little to no oxygen is found.
https://www.cell.com/cell/fulltext/S0092-8674(24)00573-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424005737%3Fshowall%3Dtrue
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How the human hippocampus contributes to value-based decision-making under uncertainty

Value-based decision-making is the process through which humans choose between options associated with different costs or efforts, as well as rewards. These choices include, for instance, selecting different products at the grocery stores or making substantial lifestyle changes to accomplish a specific goal.

Past studies on animals have found that the hippocampus, a key brain region associated with learning and memory, could play a role in the processing and evaluation of rewards, which is thought to also occur during value-based decision-making. In addition, research on humans has linked the hippocampus to memory, associative learning and imagination, which could also be connected to value-based decision-making.

Researchers  have recently been investigating the role of this brain region in the valuation and selection of different options. In one study involving individuals with cognitive impairments, they found that the hippocampus could support the active gathering of information that precedes value-based decisions in situations where outcomes are uncertain.

Their latest paper, published in Nature Human Behaviour, built on these findings to further explore how the hippocampus contributes to human decision-making under uncertainty. In this new work, they specifically examined how individuals with a neurological condition affecting the hippocampus decided between different options associated with varying rewards.

Part 1

Across four experiments requiring participants to make trade-offs between reward, uncertainty and effort, patients with acute limbic encephalitis demonstrated blunted sensitivity to reward and effort whenever uncertainty was considered, despite demonstrating intact uncertainty sensitivity.

By contrast, the valuation of these two attributes (reward and effort) was intact on uncertainty-free tasks. Reduced sensitivity to changes in reward under uncertainty correlated with the severity of hippocampal damage.

They found that patients diagnosed with ALE were sensitive to uncertainty, yet they were less sensitive to information related to changes in reward values and effort. Their study gathered evidence suggesting that the hippocampus has a context-sensitive role in value-based decision-making, which is specifically relevant under conditions of uncertainty and influences how they evaluate the rewards and efforts linked with different options.

The researchers' new observations are a further step towards better understanding the hippocampus and its contribution to decision making in instances where outcomes are uncertain.

Bahaaeddin Attaallah et al, The role of the human hippocampus in decision-making under uncertainty, Nature Human Behaviour (2024). DOI: 10.1038/s41562-024-01855-2.

Part 2

What if you just put a robot in the driver's seat instead of automating the car?

A team of roboticists  has taken a new approach to autonomous driving—instead of automating the entire car, simply put a robot in the driver's seat. The group built a robot capable of driving a car and tested it on a real-world track. They also published a paper describing their efforts on the arXiv preprint server.

Virtually all efforts to build a self-driving car have focused on making the car itself autonomous—humans sit in the passenger seat or in the back. These efforts involve adding a host of sensors in addition to processing power. They have also been met with mixed results.

In this new effort, the research team wondered if it might not be easier and cheaper simply to build a robot that can be taught how to drive a car and put it in the driver's seat of a normal vehicle. To find out if that might be possible, they built such a robot and tested it on a track at the University of Tokyo's Kashiwa Campus.

The robot is named Musashi and it was designed to operate in much the same way as a human car driver. To that end, the researchers created what they describe as a "musculoskeletal humanoid"—a robot with two arms and two legs, with feet and hands, a torso, neck and head.

They also gave it movable eyes, each equipped with a high-resolution camera. The jointed arms have hands with five digits, and the feet have "grippiness" to ensure precise control of the gas pedal and brake. The robot has a computer, of course, with software for training and to serve as the brains of the robot when driving. After building their robot, the research team put it in a small electric car and then sent it off for some test driving. In addition to simply driving around, the robot was tested on its ability to recognize and respond to objects in its path, including humans.

The team reports that initial testing was "encouraging", though they acknowledge that Musashi is a long way from being ready to drive on a public road.

Kento Kawaharazuka et al, Toward Autonomous Driving by Musculoskeletal Humanoids: A Study of Developed Hardware and Learning-Based Software, arXiv (2024). DOI: 10.48550/arxiv.2406.05573

A fully edible robot could soon end up on our plate, say scientists

A fully edible robot could soon end up on our plate if we overcome some technical hurdles, say  scientists involved in RoboFood—a project which aims to connect robots to food.

Robots and food have long been distant worlds: Robots are inorganic, bulky, and non-disposable; food is organic, soft, and biodegradable. Yet, research that develops edible robots has progressed recently and promises positive impacts: Robotic food could reduce electronic waste, help deliver nutrition and medicines to people and animals in need, monitor health, and even pave the way to novel gastronomical experiences.

But how far are we from having a fully edible robot for lunch or dessert? And what are the challenges? Scientists from the RoboFood project, based at EPFL, address these and other questions in a perspective article in the journal Nature Reviews Materials.

In the perspective article, RoboFood authors analyze which edible ingredients can be used to make edible robot parts and whole robots, and discuss the challenges of making them.

Dario Floreano et al, Towards edible robots and robotic food, Nature Reviews Materials (2024). DOI: 10.1038/s41578-024-00688-9

Drinking Alcohol on Planes May Pose a  Danger

A new look at why old age is linked to severe, even fatal COVID

A longstanding question has nagged the COVID battle for more than four years: Why does the infection cause severe disease in older people?

Ever since the beginning of the pandemic in 2020, it has been abundantly clear that older adults are at substantial risk of severe, even fatal COVID. Yet, the underlying mechanisms for their susceptibility were not always clear despite studies that took co-morbidities into account, like diabetes, heart and lung disorders, and other chronic vagaries of age that can worsen a bout with an infectious disease.

To date, scientists have blamed a dysregulated immune system, an age-related affinity toward excessive blood clotting, and an overall decline in the key soldiers of the adaptive immune system, T and B cells, to explain increased risks for severe COVID in the aging population. And while all of those factors may play a role, an inevitable question looms large: Why?

A new multicenter clinical study, reported in Science Translational Medicine, has provided comprehensive answers and peels away some of the mystery surrounding poor outcomes for older people. 

Results from the new tests bore novel data and a new level of understanding.

Older age correlated with increased SARS-CoV-2 viral abundance upon hospital admission, delayed viral clearance, and increased type I interferon gene expression in both the blood and upper airway.

Researchers also observed age-dependent up-regulation of innate immune signaling pathways and down-regulation of adaptive immune signaling pathways.

The innate immune system's monocyte production escalated while naïve T and B cells of the adaptive immune system were low.

Unlike younger patients, older ones also displayed more active innate immune pathways and a persistent rise in pro-inflammatory genes and cytokines, suggesting that advancing age may disrupt the body's ability to turn off the inflammatory response. Additionally, biomarkers of disease severity, such as interleukin-6, were the most extreme in the oldest patients. Together, these data provide insight into why age is a major risk factor for severe COVID, the research team concluded.

The study finds that aging is associated with impaired viral clearance, dysregulated immune signaling, and persistent and potentially pathologic activation of pro-inflammatory genes and proteins.

These differences raise the possibility that older adults with severe COVID-19 may respond differently, and perhaps more favorably, to immunomodulatory therapies directed at certain inflammatory cytokines.

 Hoang Van Phan et al, Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology, Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj5154

An earthquake changed the course of the Ganges: Could it happen again?

A major earthquake 2,500 years ago caused one of the largest rivers on Earth to abruptly change course, according to a new study. The previously undocumented quake rerouted the main channel of the Ganges River in what is now densely populated Bangladesh, which remains vulnerable to big quakes. The study was published in the journal Nature Communications.

Scientists have documented many river-course changes, called avulsions, including some in response to earthquakes.

It was not previously confirmed that earthquakes could drive avulsion in deltas, especially for an immense river like the Ganges.

The Ganges rises in the Himalayas and flows for some 1,600 miles, eventually combining with other major rivers including the Brahmaputra and the Meghna to form a labyrinth of waterways that empty into a wide stretch of the Bay of Bengal spanning Bangladesh and India. Together, they form the world's second-largest river system as measured by discharge. (The Amazon is first.)

Like other rivers that run through major deltas, the Ganges periodically undergoes minor or major course changes without any help from earthquakes. Sediments washed from upstream settle and build up in the channel, until eventually the river bed grows subtly higher than the surrounding flood plain.

At some point, the water breaks through and begins constructing a new path for itself. But this does not generally happen all at once—it may take successive floods over years or decades. An earthquake-related avulsion, on the other hand, can occur more or less instantaneously.

Part 1

In satellite imagery, the authors of the new study spotted what they say was probably the former main channel of the river, some 100 kilometers south of the Bangladeshi capital of Dhaka. This is a low-lying area about 1.5 kilometers wide that can be found intermittently for some 100 kilometers more or less parallel to the current river course. Filled with mud, it frequently floods, and is used mainly for rice cultivation.

Chamberlain and other researchers were exploring this area in 2018 when they came across a freshly dug excavation for a pond that had not yet been filled with water.

On one flank, they spotted distinct vertical dikes of light-colored sand cutting up through horizontal layers of mud. This is a well-known feature created by earthquakes: In such watery areas, sustained shaking can pressurize buried layers of sand and inject them upward through overlying mud. The result: literal sand volcanoes, which can erupt at the surface. Called seismites, here, they were 30 or 40 centimeters wide, cutting up through 3 or 4 meters of mud.

Further investigation showed the seismites were oriented in a systematic pattern, suggesting they were all created at the same time. Chemical analyses of sand grains and particles of mud showed that the eruptions and the abandonment and infilling of the channel both took place about 2,500 years ago.

Furthermore, there was a similar site some 85 kilometers downstream in the old channel that had filled in with mud at the same time. The authors' conclusion: This was a big, sudden avulsion triggered by an earthquake, estimated to be magnitude 7 or 8.
The quake could have had one of two possible sources, they say. One is a subduction zone to the south and east, where a huge plate of oceanic crust is shoving itself under Bangladesh, Myanmar and northeastern India. Or it could have come from giant splay faults at the foot of the Himalayas to the north, which are slowly rising because the Indian subcontinent is slowly colliding with the rest of Asia.
Part 2

A 2016 study led by Steckler shows that these zones are now building stress, and could produce earthquakes comparable to the one 2,500 years ago. The last one of this size occurred in 1762, producing a deadly tsunami that traveled up the river to Dhaka. Another may have occurred around 1140 CE.

The 2016 study estimates that a modern recurrence of such a quake could affect 140 million people. Large earthquakes impact large areas and can have long-lasting economic, social and political effects.
The Ganges is not the only river facing such hazards. Others cradled in tectonically-active deltas include China's Yellow River; Myanmar's Irrawaddy; the Klamath, San Joaquin and Santa Clara rivers, which flow off the U.S. West Coast; and the Jordan, spanning the borders of Syria, Jordan, the Palestinian West Bank and Israel.
Cascading hazards of a major Bengal basin earthquake and abrupt avulsion of the Ganges River, Nature Communications (2024). DOI: 10.1038/s41467-024-47786-4
Part 3
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How things appear in your mind’s eye

Picture a rose.

Most people can easily distinguish between that image in their mind’s eye and an actual rose flower. Now researchers say that they’ve worked out how the brain draws this distinction and where in the brain the process happens.

According to a study in monkeys, the key part of the brain is the primary visual cortex, which is also involved in vision. The authors found that neurons in this region displayed a different activity pattern for images conjured up from memory compared with that for real-time visual input. They conclude that the primary visual cortex is crucial for recalling images stored in memory.

The study in monkeys suggests that neurons there display a different activity pattern when images are conjured up from memory compared with real-time vision. Some researchers say that other areas, such as the prefrontal cortex, are more likely to be the seat of the ‘mind’s eye’. “There’s a possibility that the actual memory encoding is happening elsewhere, and that what you’re seeing in the primary visual cortex is the downstream consequences’, say the experts.

https://www.science.org/doi/10.1126/sciadv.adk3953

Bacterial batteries harvest energy from soil

Researchers developed a bacteria-powered battery which harvests energy from microorganisms in the soil to recharge itself, with a prototype already rolled out in Brazil.

Data on conditions in the field are crucial to help farmers make informed decisions and achieve the best possible yields, but powering the sensors that provide such data can be problematic.

Inventors of this technology say their low-cost, “always-on”, sustainable device – named Bactery – can help overcome some of these barriers.

The device, with an anticipated cost of around £25 per unit (US$32), operates by using bacteria present in the soil to generate electricity.

The technology makes use of microorganisms called electrigens which are naturally present in the soil and generate electrons when they consume organic matter.

One barrier to scaling, according to the researchers, is that the operating environment around the plant roots must be anaerobic – oxygen-free – to prevent the free electrons from attaching to the oxygen, which would make electricity generation unfeasible.

Therefore, he says, the system is designed to work in conditions where the plant roots are submerged in water, ensuring an oxygen-free environment and facilitating the transport of electrons.

There is a need for anaerobic conditions around one of the electrodes.

You can either install the technology in environments that accommodate this, or semi-engineer the environment to minimise the dependence on moisture.

According to Bactery, the technology promises an “install and forget” functionality and has a usable lifespan of over 25 years.

https://www.scidev.net/global/news/bacterial-batteries-harvest-ener...

Astronomers see a massive black hole awaken in real time

In late 2019, the previously unremarkable galaxy SDSS1335+0728 suddenly started shining brighter than ever before. To understand why, astronomers have used data from several space and ground-based observatories, including the European Southern Observatory's Very Large Telescope (ESO's VLT), to track how the galaxy's brightness has varied. In a study out recently, they conclude that they are witnessing changes never seen before in a galaxy—likely the result of the sudden awakening of the massive black hole at its core.

Some phenomena, like supernova explosions or tidal disruption events—when a star gets too close to a black hole and is torn apart—can make galaxies suddenly light up. But these brightness variations typically last only a few dozen or, at most, a few hundreds of days. SDSS1335+0728 is still growing brighter today, more than four years after it was first seen to "switch on." Moreover, the variations detected in the galaxy, which is located 300 million light-years away in the constellation Virgo, are unlike any seen before, pointing astronomers towards a different explanation.

The team tried to understand these brightness variations using a combination of archival data and new observations from several facilities, including the X-shooter instrument on ESO's VLT in Chile's Atacama Desert. Comparing the data taken before and after December 2019, they found that SDSS1335+0728 is now radiating much more light at ultraviolet, optical, and infrared wavelengths. The galaxy also started emitting X-rays in February 2024.

The most tangible option to explain this phenomenon is that we are seeing how the core of the galaxy is beginning to show  activity. If so, this would be the first time that we see the activation of a massive black hole in real time.

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Massive black holes—with masses over one hundred thousand times that of our sun—exist at the center of most galaxies, including the Milky Way.

These giant monsters usually are sleeping and not directly visible. In the case of SDSS1335+0728, scientists were able to observe the awakening of the massive black hole, which suddenly started to feast on gas available in its surroundings, becoming very bright.
This process has never been observed before.
Follow-up observations are still needed to rule out alternative explanations. Another possibility is that we are seeing an unusually slow tidal disruption event, or even a new phenomenon. If it is in fact a tidal disruption event, this would be the longest and faintest such event ever observed.

SDSS1335+0728: The awakening of a ∼ 10⁶M⊙ black hole, Astronomy & Astrophysics (2024). (PDF)

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Large wildfires create weather that favours more fire

A new  study shows soot from large wildfires in California traps sunlight, making days warmer and drier than they ought to be.

Many studies look at the effect of climate change on wildfires. However, this study sought to understand the reverse—whether large fires are also changing the climate.

Published in the journal Atmospheric Chemistry and Physics, the study found that large fires did have an effect. They made it hotter and drier than usual on the days the fires burned. The extra heat and aridity may then make conditions favorable for more fire.

It appears these fires are creating their own fire weather.

There are likely two reasons for this. One—soot traps heat, and two —the extra heat reduces humidity in the atmosphere, making it more difficult for clouds to form.

Fires emit smoke with black carbon, or soot. Since it is very dark, the soot absorbs sunlight more readily than bright or reflective things.

There are two types of aerosols: reflective and absorptive. Sulfate aerosols, which are byproducts of fossil fuel burning, are reflective and can cool the environment. These particles reflect the sun's energy back into space, keeping it out of the atmosphere.

Recent research points to an unfortunate byproduct of improving air quality by reducing sulfate aerosols. Since these particles have a cooling effect, removing them makes climate change more severe and leads to an increase in wildfires, especially in northern hemisphere forests.

Sulfate aerosols can also help make clouds brighter, more reflective, and more effective at cooling the planet.

The researchers note that the only way to prevent additional wildfires when cleaning up reflective sulfate air pollution is to simultaneously reduce emissions of greenhouse gases like carbon dioxide and methane.

Absorptive aerosols have the opposite effect. They trap light and heat in the atmosphere, which can raise temperatures. Black carbon, the most common aerosol emission from wildfires, is an absorbing aerosol. They not only directly make temperatures hotter, but indirectly as well by discouraging cloud formation and precipitation.

Fewer clouds mean less precipitation, which is problematic for drought-prone states.While some studies have shown an association between fires and brighter, more numerous clouds, this one did not.

James L. Gomez et al, California wildfire smoke contributes to a positive atmospheric temperature anomaly over the western United States, Atmospheric Chemistry and Physics (2024). DOI: 10.5194/acp-24-6937-2024

More than a century ago, researchers observed that rats that consumed less food lived longer. We now know that being able to manipulate lifespan is not about specifically eating less, but actually is related to signals inside cells that turn on and off specific pathways in response to available nutrients. Many of those pathways are related to aging, such as controlling protein turnover and metabolism.

Some of those signals are the ketone bodies, which consist of acetoacetate (AcAc), β-hydroxybutyrate (BHB) and to a much lesser extent, acetone. These molecules are routinely produced in the liver. They ramp up when glucose is in short supply, whether due to caloric restriction, intense exercise or low carbohydrate intake, such as with a ketogenic diet.

Diego Acuña-Catalán et al, Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice, Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101593

Study reveals genetic basis of sepsis response variability

Sepsis causes an estimated 11 million deaths worldwide per year, with one death every three seconds. 

Sepsis response varies between patients and depends on the different underlying immune response pathways.

Sepsis patients could be treated based on their immune system's response to infection, not their symptoms.

New research uncovers how different people respond to sepsis based on their genetic makeup, which could help identify who would benefit from certain treatments and lead to the development of targeted therapies.

The study, published in Cell Genomics, details the genetic basis of variability in sepsis response, and the different regulators and cell types involved in the different immune responses in each subgroup of patients.

Having a more detailed understanding of sepsis at a molecular level could identify those who would benefit from different therapies, helping to design rapid tests, organize clinical trials, and develop targeted treatments based on the individual immune response.

The ultimate aim is for patients to receive the most effective treatment for their sepsis more quickly, based on their immune response rather than their symptoms. In the future, this approach to personalized medicine could also be applied to other less severe infections, not just sepsis.

Sepsis arises when the body has an extreme response to an infection and injures its own tissues and organs. Sepsis can cause different downstream immune responses in different people. Depending on this immune response, the treatment varies. However, it is difficult to identify which response is happening based on symptoms alone. Sepsis can progress quickly, and if the wrong treatment is given, valuable time could be lost.

Understanding the regulatory networks underlying the different patient responses provides additional information for developing treatments that work with the immune system and are a step towards a personalized medicine approach to treating sepsis.

K. Burnham, eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis, Cell Genomics (2024). DOI: 10.1016/j.xgen.2024.100587. www.cell.com/cell-genomics/ful … 2666-979X(24)00171-X

Discovery of 'new rules of the immune system' could improve treatment of inflammatory diseases, say scientists

Scientists  have discovered that a type of white blood cell—called a regulatory T cell—exists as a single large population of cells that constantly move throughout the body looking for, and repairing, damaged tissue.

This overturns the traditional thinking that regulatory T cells exist as multiple specialist populations that are restricted to specific parts of the body. The finding has implications for the treatment of many different diseases—because almost all diseases and injuries trigger the body's immune system.

Current anti-inflammatory drugs treat the whole body, rather than just the part needing treatment. The researchers say their findings mean it could be possible to shut down the body's immune response and repair damage in any specific part of the body, without affecting the rest of it. This means that higher, more targeted doses of drugs could be used to treat disease—potentially with rapid results.

Researchers have uncovered new rules of the immune system. This 'unified healer army' can do everything—repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles. To think that we could use it in such an enormous range of diseases is fantastic: it's got the potential to be used for almost everything.

To reach this discovery, the researchers analyzed the regulatory T cells present in 48 different tissues in the bodies of mice. This revealed that the cells are not specialized or static, but move through the body to where they're needed. The results are published in the journal Immunity.

Most white blood cells attack infections in the body by triggering an immune response. In contrast, regulatory T cells act like a 'unified healer army' whose purpose is to shut down this immune response once it has done its job—and repair the tissue damage caused by it.

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program, Immunity (2024). DOI: 10.1016/j.immuni.2024.05.023. www.cell.com/immunity/fulltext … 1074-7613(24)00277-2

Starlings found to expend 25% less energy in follower position compared to flying solo

A multidisciplinary, multi-institutional team of researchers  has found that starlings that fly in a follower position expend 25% less energy than when they fly solo. In their study, published in the Proceedings of the National Academy of Sciences, the group designed complex experiments to learn more about the amount of energy savings for birds following another bird in flight rather than going it alone.

Prior research and logic suggest that if a bird were to fly behind another bird, it would use less energy because there would be less wind resistance. But testing the idea has proven difficult. In this new effort, the research team designed and carried out what they describe as "difficult" experiments to test energy expenditure by birds in flight.

Sonja I. Friman et al, It pays to follow the leader: Metabolic cost of flight is lower for trailing birds in small groups, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2319971121

Researchers create new class of materials called 'glassy gels'

Researchers have created a new class of materials called "glassy gels" that are very hard and difficult to break despite containing more than 50% liquid. Coupled with the fact that glassy gels are simple to produce, the material holds promise for a variety of applications.

A paper describing this work, titled "Glassy Gels Toughened by Solvent," appears in the journal Nature.

Gels and glassy polymers are classes of materials that have historically been viewed as distinct from one another. Glassy polymers are hard, stiff and often brittle. They're used to make things like water bottles or airplane windows. Gels—such as contact lenses—contain liquid and are soft and stretchy.

Now researchers have created a class of materials that they've termed glassy gels, which are as hard as glassy polymers, but—if you apply enough force—can stretch up to five times their original length, rather than breaking.

What's more, once the material has been stretched, you can get it to return to its original shape by applying heat. In addition, the surface of the glassy gels is highly adhesive, which is unusual for hard materials.

A key thing that distinguishes glassy gels is that they are more than 50% liquid, which makes them more efficient conductors of electricity than common plastics that have comparable physical characteristics.

Considering the number of unique properties they possess, researchers are optimistic that these materials will be very useful.

Michael Dickey, Glassy gels toughened by solvent, Nature (2024). DOI: 10.1038/s41586-024-07564-0. www.nature.com/articles/s41586-024-07564-0

New technology provides electrifying insights into how catalysts work at the atomic level

A team led by Lawrence Berkeley National Laboratory (Berkeley Lab) has invented a technique to study electrochemical processes at the atomic level with unprecedented resolution and used it to gain new insights into a popular catalyst material.

Electrochemical reactions—chemical transformations that are caused by or accompanied by the flow of electric currents—are the basis of batteries, fuel cells, electrolysis, and solar-powered fuel generation, among other technologies. They also drive biological processes such as photosynthesis and occur under the Earth's surface in the formation and breakdown of metal ores.

The scientists have developed a cell—a small enclosed chamber that can hold all the components of an electrochemical reaction—that can be paired with transmission electron microscopy (TEM) to generate precise views of a reaction at an atomic scale. Better yet, their device, which they call a polymer liquid cell (PLC), can be frozen to stop the reaction at specific timepoints, so scientists can observe composition changes at each stage of a reaction with other characterization tools.

In a paper appearing in Nature, the team describes their cell and a proof of principle investigation using it to study a copper catalyst that reduces carbon dioxide to generate fuels.

Haimei Zheng, Atomic dynamics of electrified solid–liquid interfaces in liquid-cell TEM, Nature (2024). DOI: 10.1038/s41586-024-07479-w. www.nature.com/articles/s41586-024-07479-w

Air pollution linked to nearly 2,000 child deaths a day: Report

Nearly 2,000 children die every day from health problems linked to air pollution, which is now the second biggest risk factor for early death worldwide, a report said recently.

Exposure to air pollution contributed to the deaths of 8.1 million people—around 12 percent of all fatalities—in 2021, according to the report from the US-based Health Effects Institute.

This means air pollution has overtaken tobacco use and poor diet to become the second leading risk factor for early death, behind only high blood pressure, it said.

Little kids are particularly vulnerable to air pollution, and the institute partnered with the UN Children's Fund UNICEF for its annual State of Global Air report.

Air pollution contributed to the deaths of more than 700,000 children under the age of five, the report found.

More than 500,000 of those deaths were attributed to cooking indoors using dirty fuels such as coal, wood or dung, mostly in Africa and Asia.

Nearly every person in the world breathes unhealthy levels of air pollution every day, the report found. Over 90 percent of the deaths were linked to tiny airborne pollutants called PM2.5, which measure 2.5 micrometres or less, it said. Inhaling PM2.5 has been found to increase the risk of lung cancer, heart disease, stroke, diabetes and a range of other health problems.

The report aimed to link the rates of such diseases with air pollution levels.

But despite the "pretty stark" figures, the report could still be underestimating air pollution's impact, according to experts.

It did not take into account, for instance, how air pollution could affect brain health, neurodegenerative diseases or what impact using solid fuels for heating could have.

The report also found that ozone pollution—which is expected to get worse as the world warms due to human-driven climate change—was linked to nearly 500,000 deaths in 2021.

Source: AFP and other news agencies

https://ceh.unicef.org/spotlight-risk/air-pollution

Travelers urged to keep it local in the name of sustainable tourism

From rolling vineyards to stunning beaches, there's no shortage of beauty to discover in our own backyards.

A tourism expert from the University of South Australia is urging travelers to support local destinations and experiences close to home, instead of long-haul international trips, to lessen the impacts of tourism on the environment.

Adjunct Senior Lecturer in Tourism Management Dr. Freya Higgins-Desbiolles says we should be considering more localized travel and doing everything we can to reduce unnecessary emissions.

She says space travel, private jet travel and mass travel to far off and remote and extreme environments are "unethical" and contribute to a culture of privileged over-consumption.

"In these conditions, it is hard to justify tourism . We have to question our use of cruising or flights in our tourism consumption," she says.

We need to create a cultural shift that sees tourism consumption as a luxury to be savored and not something we can have every year or multiple times a year, like many have come to expect in the Global North. Shifting to an appreciation of local leisure and domestic travels and lower expectations of long-haul international travel is a must.

The Global North, i.e., the northern hemisphere, is responsible for 92% of global emissions.

Dr. Higgins-Desbiolles outlines how tourism is contributing to the depletion of natural resources, pollution, over-consumption and environmental destruction.

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She recommends that travelers be more considerate in their choices of holiday destinations and reflect on the impact of their activities on the environment.

"Tourism should be defined by the local community, with decision-making controlled at the lowest level and an emphasis on the interrelationships between people, place, ecology and all living things. We need to slow down—stay longer, stay local, be thoughtful with our holiday choices," she says. "There are so many resources out there like Rise Travel Institute or The Travel Foundation that shed light on sustainable, responsible and just tourism.
It's about respecting the destination, looking out for codes of responsibility, and making yourself aware of the culture and what challenges the communities you're visiting are facing. I encourage people to try being more conscious on their next trip—stay in one place longer, travel more slowly, go for nature walks, engage with the culture, try to leave the destination a better place than how you found it."
Tourism Research Australia forecasts that over the next five years, domestic travel will see only moderate growth, largely due to increased competition from international outbound travel, which is set to continue to climb.

The tourism industry contributes 8% of total global carbon emissions, yet the Tourism Panel on Climate Change—an international body of climate scientists and tourism experts—focuses on profit-first climate-resilient tourism, rather than addressing the contribution of the industry to environmental destruction.
Dr. Higgins-Desbiolles says it's up to everyone to make more environmentally conscious travel decisions.

"We must see all governments willing to legislate and regulate tourism better. For example, France has passed legislation banning short-haul flights—the transport method contributing the second most to emissions—when a train journey of less than 2.5 hours is available," she says.

"Meaningful change is needed at every level; governments, organizations and travelers need to put their focus towards sustainable and climate-just tourism."

Freya Higgins-Desbiolles, The end of tourism? Contemplations of collapse, Journal of Tourism Futures (2024). DOI: 10.1108/JTF-11-2023-0259

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Personalized cancer vaccines are coming
The same mRNA technology that underpins COVID-19 vaccines could train the immune system to attack cancer cells. In a small trial, mRNA treatment in combination with an established immunotherapy nearly halved the risk of melanoma recurrence, compared with the immunotherapy on its own. We have the first proof of concept that these things can work, says cancer immunologists. Now, we just need to make them better. Key to this will be to predict which of the cancer cells’ mutant proteins — unique to each person and cancer type — the vaccine needs to target.

https://www.nature.com/articles/d41586-024-01717-x?utm_source=Live+...

Improving crops with laser beams and 3D printing

A demonstration of how new technologies can be used in 21st century crop breeding comes from just published research that combines laser scanning and 3D printing to create a detailed 3D model of a sugar beet plant.

Taking the next step beyond having genetic information to guide intelligent breeding, the 3D plant models here capture the essential characteristics of the above-ground parts of the sugar beet plant and can be used for AI-assisted crop improvement pipelines. The sugar beet plant models are reproducible and fit for field use.

All the research information, data, methodology, as well as the 3D printing files are freely available. Crop management is gaining much needed tools, and, of course, everyone can now print their own 3D sugar beet plant (Minimum maintenance required.) The sugar beet plant 3D model and its validation are presented in a  new publication    in the journal GigaScience.

Jonas Bömer et al, A 3D printed plant model for accurate and reliable 3D plant phenotyping, GigaScience (2024). DOI: 10.1093/gigascience/giae035

Researchers discover why people who lack a specific blood group are genetically predisposed to be overweight or obese

A team of international researchers has discovered that people with a genetic variant that disables the SMIM1 gene have higher body weight because they expend less energy when at rest.

SMIM1 was only identified 10 years ago, while researchers were searching for the gene encoding a specific blood group, known as Vel. One in 5,000 people lack both copies of the gene, making them Vel-negative. The findings from the new research suggest that this group is also more likely to be overweight, a conclusion that could one day lead to new treatments.

The study found that people without both copies of the gene have other measures linked to obesity, including high levels of fat in the blood, signs of fat tissue dysfunction, increased liver enzymes as well as lower levels of thyroid hormones.

SMIM1 absence is associated with reduced energy expenditure and excess weight', Med (2024). DOI: 10.1016/j.medj.2024.05.015. www.cell.com/med/fulltext/S2666-6340(24)00219-8

Turning infrared light visible: New device uses 2D material to up-convert infrared light

The human eye can only see light at certain frequencies (called the visible spectrum), the lowest of which constitutes red light. Infrared light, which we can't see, has an even lower frequency than red light. Researchers at the Indian Institute of Science (IISc) have now fabricated a device to increase or "up-convert" the frequency of short infrared light to the visible range.

Up-conversion of light has diverse applications, especially in defense and optical communications. In a first, the IISc team used a 2D material to design what they call a non-linear optical mirror stack to achieve this up-conversion, combined with widefield imaging capability. The stack consists of multilayered gallium selenide fixed to the top of a gold reflective surface, with a silicon dioxide layer sandwiched in between.
Traditional infrared imaging uses exotic low-energy bandgap semiconductors or micro-bolometer arrays, which usually pick up heat or absorption signatures from the object being studied.

Infrared imaging and sensing is useful in diverse areas, from astronomy to chemistry. For example, when infrared light is passed through a gas, sensing how the light changes can help scientists tease out specific properties of the gas. Such sensing is not always possible using visible light.
However, existing infrared sensors are bulky and not very efficient. They are also export-restricted because of their utility in defense. There is, therefore, a critical need to develop indigenous and efficient devices.

The method used by the IISc team involves feeding an input infrared signal along with a pump beam onto the mirror stack. The nonlinear optical properties of the material constituting the stack result in a mixing of the frequencies, leading to an output beam of increased (up-converted) frequency, but with the rest of the properties intact. Using this method, they were able to up-convert infrared light of wavelength around 1550 nm to 622 nm visible light. The output light wave can be detected using traditional silicon-based cameras.

 Jyothsna Konkada Manattayil et al, 2D Material Based Nonlinear Optical Mirror for Widefield Up‐Conversion Imaging from Near Infrared to Visible Wavelengths, Laser & Photonics Reviews (2024). DOI: 10.1002/lpor.202400374

Four in five people want more climate action: UN survey

Four in every five people want their country to strengthen its commitments to addressing climate change, according to a global poll of 75,000 participants published this week.

The survey by the UN Development Program, Oxford University and GeoPoll posed 15 questions by randomized telephone calls to people in 77 countries representing 87 percent of the world's population.

The key finding was that 80 percent of respondents want their governments to increase efforts to fight against global warming.

Poorer countries beat this drum the loudest, with 89 percent in favor, though appetite is also high in the wealthy G20 nations (76 percent), according to the survey.

China (73 percent) and the United States (66 percent)—the world's biggest greenhouse gas emitters—also saw a majority of respondents in favor of climate action.

As world leaders decide on the next round of pledges under the Paris Agreement by 2025, these results are undeniable evidence that people everywhere support bold climate action.

A majority of respondents in 62 of the 77 countries surveyed said they supported a quick transition away from fossil fuels to clean energy.

Worries about global warming have also increased, the survey found, with 56 percent saying they think about climate change at least once a week.

Over half (53 percent) of those surveyed said they were more worried about climate change than last year, compared with 15 percent who said they were less worried.

More than two-thirds of survey respondents (69 percent) said that global warming had impacted their life decisions, such as where to live or work and what to buy.

Source: AFP and other news agencies.

Defunct satellites burning up in the atmosphere could damage the ozone layer

Communications companies such as Starlink plan to launch tens of thousands of satellites into orbit around Earth over the next decade or so. The growing swarm is already causing problems for astronomers, but recent research has raised another question: What happens when they start to come down?

When these satellites reach the end of their useful life, they will fall into Earth's atmosphere and burn up. Along the way, they will leave a trail of tiny metallic particles.

According to a study published last week by a team of American researchers, this satellite rain may dump 360 tons of tiny aluminum oxide particles into the atmosphere each year. The aluminum will mostly be injected at altitudes between 50 and 85 kilometers, but it will then drift down to the stratosphere—home to Earth's protective ozone layer.

What does that mean? According to the study, the satellite's contrail could facilitate ozone-destroying chemical reactions.

This could destroy the ozone layer that protects life on Earth.

https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2024GL109280

https://www.space.com/air-pollution-reentering-space-junk-detected

https://theconversation.com/defunct-satellites-burning-up-in-the-at...

How extreme heat kills

The World Health Organisation (WHO) has calculated that heat kills at least half a million people every year but warns that the real figure could be up to 30 times higher.

How does extreme heat damage the body and how physical activity outdoors raises the risk?

In normal conditions, the body regulates its own temperature like a thermostat, holding it steady at about 36.8C (98.2F).

When outside heat rises, the body cools itself by raising blood-flow to vessels near the skin.

This emits heat at the surface, while perspiration also cools the outside of the body.

To ensure the correct functioning of the cells, enzymes and vital organs, the body's temperature must stay constant, whatever the external conditions.

During an outside activity such as workers working in fields, where people spend hours outdoors in the sun, "the body can quickly become exhausted and can no longer find the reserves of water needed to perspire". Then the kidneys, heart and brain risk overheating and "stop working".

When the body's natural thermostat is overwhelmed in this way, symptoms strike: fatigue, headaches, fever and broken sleep.

These can herald more serious effects, such as dehydration, which chokes off water to the vital organs.

The biggest risk is heatstroke, when the body's temperature exceeds 40C (104F) as the body has its limits. When the weather is too hot or when extreme heat is combined with physical activity, for example, the body can find itself unable to self-regulate.

Babies, the elderly, people with health problems and outdoor workers are most at risk.

The number of sweat glands in the body decreases with age, leaving the body less able to cool itself.

Several factors determine our reaction to heat: age, body mass, physical activity, genes. But when the heat is too strong, even young, healthy bodies can lack the energy to keep the temperature close to 37C.

The WHO warns that hot nights pose a particular health risk.

Nighttime heat gives the body no chance to cool down, leading to a rise in heart attacks.

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