Comparing individual patient blood samples to their biopsies, the team identified 158 genes that were differentially expressed across all four organs during cases of rejection. That's nearly 20 times higher than what was expected by chance.

This discovery is pivotal as it allows us to develop strategies to enhance the success rates of all transplants.
Some of these shared biomarkers are involved in the secretion of proteins that stimulate white blood cells, enzymes that induce cell death, receptors on cells that allow materials in and out, and bone marrow cells involved in the immune response.
These findings demonstrate a "unifying pan-organ molecular marker".
The research team has made an interactive website that allows scientists around the world to compare possible biomarkers of transplant rejection against other methods, providing a much-needed standardized evaluation. This atlas has led to the development of a proof of principle for a universal blood test that can predict the likelihood of transplant rejection before it occurs.

https://www.nature.com/articles/s41591-024-03030-6

Part 2

Fire on Earth vs. in space - Gravity has more of an impact than you might think!

The Rarest Eye Colors in the World - Eye Colors Explained

NASA's Curiosity rover discovers yellow sulfur crystals in a Martian rock

On May 30th when a rock that NASA's Curiosity Mars rover drove over cracked open to reveal something never seen before on the Red Planet: yellow sulfur crystals.

Since October 2023, the rover has been exploring a region of Mars rich with sulfates, a kind of salt that contains sulfur and forms as water evaporates. But where past detections have been of sulfur-based minerals—in other words, a mix of sulfur and other materials—the rock Curiosity recently cracked open is made of elemental (pure) sulfur. It isn't clear what relationship, if any, the elemental sulfur has to other sulfur-based minerals in the area.

While people associate sulfur with the odor from rotten eggs (the result of hydrogen sulfide gas), elemental sulfur is odorless. It forms in only a narrow range of conditions that scientists haven't associated with the history of this location. And Curiosity found a lot of it—an entire field of bright rocks that look similar to the one the rover crushed.

It's one of several discoveries Curiosity has made while off-roading within Gediz Vallis channel, a groove that winds down part of the 3-mile-tall (5-kilometer-tall) Mount Sharp, the base of which the rover has been ascending since 2014. Each layer of the mountain represents a different period of Martian history. Curiosity's mission is to study where and when the planet's ancient terrain could have provided the nutrients needed for microbial life, if any ever formed on Mars.

Source: NASA

Ovarian Egg Cells Live an Unusually Long Time, And We Finally Know Why

Mammals are born with all the oocytes (or egg cells) they'll ever need, but how the cells remain alive and active for so long is something of a mystery. A pair of studies have now revealed it could all come down to the robustness of their proteins. The two investigations used traceable isotopes incorporated into growing mouse fetuses to measure the lifespans of proteins in their ovaries, finding many of them survived far longer than proteins in the rest of the body. The presence of these 'long life' molecules and the support they give oocytes and the surrounding cells seem to be crucial in maintaining fertility.
the first study analyzed oocytes in 8-week-old mice, when the animals were at their reproductive prime. Around 10 percent of the oocyte proteins produced while the animals were in utero were still present.

The researchers then looked at older mice to see how long it took for these persistent proteins to break down. The answer: not very quickly at all, relatively speaking. Some of the proteins remained in the ovaries of the mice for most of the animals' short lives.
The data establishes that many proteins in oocytes and the ovary are unusually stable, with half-lives well above those reported in other cell types and organs, including the liver, heart, cartilage, muscle and the brain.
The half-lives of many proteins are much higher in the ovary than in other organs, and many additional proteins are uniquely long-lived in the ovary.
Part 1

A second study by researchers also found evidence of long-lasting ovary proteins in young mice, including proteins that were present before the mice were born. Certain long-lasting proteins, such as ZP3, were identified for future studies.

Some of these hardy proteins were present in the cell mitochondria, where a cell's energy is generated. Since mitochondria are inherited as part of the egg cell a mammal grows from, it could ensure these critical organelles can remain functional as they're passed from mother to offspring.

Eventually, even these proteins that live way beyond the norm fade away and die, the researchers report. That could be connected to the natural decline in a woman's ability to have children, the study suggests – and could ultimately point to ways to treat or at least better diagnose infertility.

The findings from these studies of mice still need to be replicated in humans, but if they are, it would represent a significant step forward in our understanding of fertility and how oocytes can be kept in a healthy state.

https://elifesciences.org/reviewed-preprints/93172

https://www.nature.com/articles/s41556-024-01442-7

Part 2

Biologists discover male elephants use infrasonic rumbles to signal 'let's go'

Bull elephants gather in the evening coolness to drink. After a spell, a senior male lifts his head and turns from the waterhole. With ears flapping gently, he lets out a deep, resonant rumble.

One by one, the others respond, their voices overlapping in a sonorous, infrasonic chorus that whispers across the savanna. This elephant barbershop quartet conveys a clear message: It's time to move on.

Gradually, the elephants shift, their massive bodies swaying as they follow their rumbling leader to the next stop on their nocturnal wanderings.

For the first time, scientists  have documented male elephants using "let's go" rumbles to signal the start of group departures from the Mushara waterhole in Etosha National Park, Namibia. The vocalizations are initiated by the most socially integrated, and often the most dominant, males in close-knit social groups.

The findings, detailed in the open-access journal PeerJ, are surprising because this behavior was previously thought to be exclusive to female elephants in family groups.

Male elephants, typically considered to have loose social ties, engaging in such sophisticated vocal coordination to trigger action is surprising. 

The "let's go" rumbles observed in male elephants bear striking similarities to those previously recorded in female elephants. The researchers hypothesized that male elephants likely learn the behaviour when they are young.

In the case of both male and female elephants, the initiator's call is followed by the next individual's rumble, with each elephant waiting for the preceding call to nearly finish before adding their own voice. This creates a harmonious, turn-taking pattern akin to a barbershop quartet.

It's very synchronized and ritualized. When one goes high, the other goes low, and they have this vocal space where they're coordinating.

PeerJ (2024). doi.org/10.7717/peerj.17767

Smell of human stress can affect dogs' emotions, leading them to make more pessimistic choices

Dogs experience emotional contagion from the smell of human stress, leading them to make more 'pessimistic' choices, new research finds. 

Evidence in humans suggests that the smell of a stressed person subconsciously affects the emotions and choices made by others around them.

The researchers recruited 18 dog-owner partnerships to take part in a series of trials with different human smells present. During the trials, dogs were trained that when a food bowl was placed in one location, it contained a treat, but when placed in another location, it was empty.

Once a dog learned the difference between these bowl locations, they were faster to approach the location with a treat than the empty location. Researchers then tested how quickly the dog would approach new, ambiguous bowl locations positioned between the original two.

A quick approach reflected 'optimism' about food being present in these ambiguous locations—a marker of a positive emotional state—while a slow approach indicated 'pessimism' and negative emotion. These trials were repeated while each dog was exposed to either no odor or the odors of sweat and breath samples from humans in either a stressed (arithmetic test) or relaxed (listening to soundscapes) state.

Researchers discovered that the stress smell made dogs slower to approach the ambiguous bowl location nearest the trained location of the empty bowl. An effect that was not seen with the relaxed smell. These findings suggest that the stress smell may have increased the dogs' expectations that this new location contained no food, similar to the nearby empty bowl location.

Researchers suggest this 'pessimistic' response reflects a negative emotional state and could possibly be a way for the dog to conserve energy and avoid disappointment.

The team also found that dogs continued to improve their learning about the presence or absence of food in the two trained bowl locations and that they improved faster when the stress smell was present.

Parr-Cortes, Zoe ; Muller, Carsten T ; Talas, Laszlo et al, The odour of an unfamiliar stressed or relaxed person affects dogs' responses to a cognitive bias test, Scientific Reports (2024). DOI: 10.1038/s41598-024-66147-1

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Scientists uncover fundamental rules for how dengue virus infects its mosquito and human hosts

Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease.

Now, research from the Stowers Institute for Medical Research has uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.

Exposing Dengue’s Invasion Strategies

 Luciana A Castellano et al, Dengue virus preferentially uses human and mosquito non-optimal codons, bioRxiv (2023). DOI: 10.1101/2023.06.14.544804

Luciana A Castellano et al, Dengue virus preferentially uses human and mosquito non-optimal codons, Molecular Systems Biology (2024). doi.org/10.1038/s44320-024-00052-7

New study identifies two proteins that may contribute to stroke recurrence

People who experience an arterial ischemic stroke (AIS) or transient ischemic stroke (TIA) are at an increased risk of suffering a second stroke or other major adverse cardiovascular event (MACE), making it critically important to identify risk factors and treatments to prevent these subsequent occurrences.

A new study has identified new genetic and molecular risk factors that may reveal new pathways for treating patients after they experience their first stroke.

Published in Stroke, the study identified CCL27 and TNFRSF14, two proteins that are associated with subsequent MACE, but not initial strokes. These proteins are known to activate inflammation, which plays a key role in the development of strokes and many chronic conditions and diseases.

The findings suggest that inflammation is a contributing factor to MACE outcomes among people after they have their first stroke.

Utilizing genetic information and medical history data from two large biobanks, the VA's Million Veteran Program and UK Biobank, the research team conducted ancestry-specific genome-wide association studies (GWAS) to find associations between DNA and incident and subsequent AIS and MACE.

GWAS are typically performed to determine whether individuals have had a medical event for the first time, but applying this method to subsequent MACE events could shed novel insights about stroke progression, information that would be valuable for therapeutic drug identification, the researchers say.

Protein Identification for Stroke Progression via Mendelian Randomization in Million Veteran Program and UK Biobank, Stroke (2024). DOI: 10.1161/STROKEAHA.124.047103

Blood proteins predict the risk of developing more than 60 diseases, study finds

Research on thousands of proteins measured from a drop of blood demonstrates the ability of proteins to predict the onset of many diverse diseases.

The researchers used data from the UK Biobank Pharma Proteomics Project (UKB-PPP), the largest proteomics study to date with measurements for approximately 3,000 plasma proteins from a randomly selected set of over 40,000 UK Biobank participants.

The protein data is linked to the participants' electronic health records. The authors used advanced analytical techniques to pinpoint, for each disease, a 'signature' of between the five and 20 proteins most important for prediction.

The researchers report the ability of protein 'signatures' to predict the onset of 67 diseases including multiple myeloma, non-Hodgkin lymphoma, motor neuron disease, pulmonary fibrosis, and dilated cardiomyopathy.

The protein prediction models out-performed models based on standard, clinically recorded information. Prediction based on blood cell counts, cholesterol, kidney function and diabetes tests (glycated hemoglobin) performed less well than the protein prediction models for most examples.

The patient benefits of measuring and discussing the risk of future heart attack and stroke ('cardiovascular risk scores') are well established. This research opens up new prediction possibilities for a wide range of diseases, including rarer conditions. Many of these can currently take months and years to diagnose, and this research offers wholly new opportunities for timely diagnoses.

These findings require validation in different populations, including people with and without symptoms and signs of diseases and in different ethnic groups.

 Proteomic signatures improve risk prediction for common and rare diseases', Nature Medicine (2024). DOI: 10.1038/s41591-024-03142-z

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'New El Niño' discovered south of the equator

A small area of the southwestern Pacific Ocean, near New Zealand and Australia, can trigger temperature changes that affect the entire Southern Hemisphere, a new study has found.

The new climate pattern, which shares some characteristics with the El Niño phenomenon, has been named the "Southern Hemisphere Circumpolar Wavenumber-4 Pattern."

Unlike El Niño, which starts in the tropics, this new pattern begins in the mid-latitudes. The study, published this month in the Journal of Geophysical Research: Oceans, highlights how important the interaction between the ocean and atmosphere is for our climate.

This discovery is like finding a new switch in Earth's climate. It shows that a relatively small area of the ocean can have wide-reaching effects on global weather and climate patterns.

Understanding this new weather system could greatly improve weather forecasting and climate prediction, especially in the Southern Hemisphere. It might help explain climate changes that were previously mysterious and could improve our ability to predict extreme weather and climate events.

 Balaji Senapati et al, Southern Hemisphere Circumpolar Wavenumber‐4 Pattern Simulated in SINTEX‐F2 Coupled Model, Journal of Geophysical Research: Oceans (2024). DOI: 10.1029/2023JC020801

Switching from gas to electric stoves cuts indoor air pollution

Switching from a gas stove to an electric induction stove can reduce indoor nitrogen dioxide air pollution, a known health hazard, by more than 50 percent according to new research led by scientists.  The findings appear in the journal Energy Research & Social Science.

this study is the the first to evaluate the feasibility and benefits of transitioning from gas to induction stoves in affordable housing. The study is the first to evaluate the effects of residential cooking electrification in a public housing setting.

 Misbath Daouda et al, Out of Gas, In with Justice: Findings from a gas-to-induction pilot in low-income housing in NYC, Energy Research & Social Science (2024). DOI: 10.1016/j.erss.2024.103662

Scientists use AI to predict a wildfire's next move accurately

Researchers  have developed a new method to accurately predict wildfire spread. By combining satellite imagery and artificial intelligence, their model offers a potential breakthrough in wildfire management and emergency response.

Detailed in an early study proof published in Artificial Intelligence for the Earth Systems, the new model uses satellite data to track a wildfire's progression in real time, then feeds this information into a sophisticated computer algorithm that can accurately forecast the fire's likely path, intensity and growth rate.

This model represents an important step forward in our ability to combat wildfires.

 Bryan Shaddy et al, Generative Algorithms for Fusion of Physics-Based Wildfire Spread Models with Satellite Data for Initializing Wildfire Forecasts, Artificial Intelligence for the Earth Systems (2024). DOI: 10.1175/AIES-D-23-0087.1

Dual action antibiotic could make bacterial resistance nearly impossible

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research.

For a new paper in Nature Chemical Biology, researchers probed how a class of synthetic drugs called macrolones disrupt bacterial cell function to fight infectious diseases. Their experiments demonstrate that macrolones can work two different ways—either by interfering with protein production or corrupting DNA structure.

Because bacteria would need to implement defenses to both attacks simultaneously, the researchers calculated that drug resistance is nearly impossible.

The beauty of this antibiotic is that it kills through two different targets in bacteria. If the antibiotic hits both targets at the same concentration, then the bacteria lose their ability to become resistant via acquisition of random mutations in any of the two targets.

Macrolones are synthetic antibiotics that combine the structures of two widely used antibiotics with different mechanisms. Macrolides, such as erythromycin, block the ribosome, the protein manufacturing factories of the cell. Fluoroquinolones, such as ciprofloxacin, target a bacteria-specific enzyme called DNA gyrase.

Elena V. Aleksandrova et al, Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms, Nature Chemical Biology (2024). DOI: 10.1038/s41589-024-01685-3

New findings shed light on risks and benefits of integrating AI into medical decision-making

Researchers have found that an artificial intelligence (AI) model solved medical quiz questions—designed to test health professionals' ability to diagnose patients based on clinical images and a brief text summary—with high accuracy. However, physician-graders found the AI model made mistakes when describing images and explaining how its decision-making led to the correct answer.

The findings, which shed light on AI's potential in the clinical setting, were published in npj Digital Medicine. 

Integration of AI into health care holds great promise as a tool to help medical professionals diagnose patients faster, allowing them to start treatment sooner.

However, as this study shows, AI is not advanced enough yet to replace human experience, which is crucial for accurate diagnosis.

Part 1

The AI model and human physicians answered questions from the New England Journal of Medicine's Image Challenge. The challenge is an online quiz that provides real clinical images and a short text description that includes details about the patient's symptoms and presentation, then asks users to choose the correct diagnosis from multiple-choice answers.

The researchers tasked the AI model to answer 207 image challenge questions and provide a written rationale to justify each answer. The prompt specified that the rationale should include a description of the image, a summary of relevant medical knowledge, and provide step-by-step reasoning for how the model chose the answer.

Nine physicians from various institutions were recruited, each with a different medical specialty, and answered their assigned questions first in a "closed-book" setting, (without referring to any external materials such as online resources) and then in an "open-book" setting (using external resources). The researchers then provided the physicians with the correct answer, along with the AI model's answer and corresponding rationale. Finally, the physicians were asked to score the AI model's ability to describe the image, summarize relevant medical knowledge, and provide its step-by-step reasoning.

The researchers found that the AI model and physicians scored highly in selecting the correct diagnosis. Interestingly, the AI model selected the correct diagnosis more often than physicians in closed-book settings, while physicians with open-book tools performed better than the AI model, especially when answering the questions ranked most difficult.

Importantly, based on physician evaluations, the AI model often made mistakes when describing the medical image and explaining its reasoning behind the diagnosis—even in cases where it made the correct final choice. In one example, the AI model was provided with a photo of a patient's arm with two lesions. A physician would easily recognize that both lesions were caused by the same condition. However, because the lesions were presented at different angles—causing the illusion of different colors and shapes—the AI model failed to recognize that both lesions could be related to the same diagnosis.

The researchers argue that these findings underpin the importance of evaluating multi-modal AI technology further before introducing it into the clinical setting.

 Hidden Flaws Behind Expert-Level Accuracy of Multimodal GPT-4 Vision in Medicine, npj Digital Medicine (2024). DOI: 10.1038/s41746-024-01185-7. www.nature.com/articles/s41746-024-01185-7

Part 2

Electric scooter and bike accidents are soaring across the US, researchers report

In the crowded urban landscape, where small electric vehicles—primarily scooters and bicycles—have transformed short distance travel,  researchers are reporting a major national surge in accidents tied to "micromobility."

The researchers analyzed injuries and hospitalizations from electric bicycles, electric scooters, conventional bicycles and conventional scooters. The study, which appears July 23 in JAMA Network Open, is believed to be the first investigation into recent injury patterns in the U.S.

E-bicycle injuries doubled every year from 2017 to 2022, while e-scooter injuries rose by 45%. Injured e-riders tended to be slightly older and wore helmets less often than conventional riders. And e-scooter riders were more likely to sustain internal injuries than conventional scooter riders, while upper extremity injuries were more common among non-EV riders.

JAMA Network Open (2024). jamanetwork.com/journals/jaman … tworkopen.2024.24131

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Chinese lunar probe finds water in moon samples

A Chinese lunar probe found traces of water in samples of the moon's soil, scientists have said, as the country pushes its ambitious space program into high gear.

The Chang'e-5 rover completed its mission in 2020, returning to Earth with rock and  soil samples from the moon.

The lunar samples "revealed the presence of trace water", the group of scientists from Chinese universities wrote in the Nature Astronomy journal published recently.

Shifeng Jin et al, Evidence of a hydrated mineral enriched in water and ammonium molecules in the Chang'e-5 lunar sample, Nature Astronomy (2024). DOI: 10.1038/s41550-024-02306-8 , www.nature.com/articles/s41550-024-02306-8

Evidence of ‘Dark oxygen’ production from the sea floor

A chemical reaction could be producing oxygen by splitting water molecules, but its source of energy remains unknown.

The phenomenon was discovered in a region strewn with ancient, plum-sized formations called polymetallic nodules, which could play a part in the oxygen production by catalysing the splitting of water molecules, researchers suspect. The findings are published in Nature Geoscience.
Something is pumping out large amounts of oxygen at the bottom of the Pacific Ocean, at depths where a lack of sunlight makes photosynthesis impossible. The find has surprised scientists and the source remains a mystery. The oxygen might be generated by metal-rich mineral deposits, or nodules. To researchers’ surprise, they measured voltages of up to 0.95 volts across the surface of the nodules. It is possible that the nodules catalyse the splitting of water into oxygen and hydrogen, but more experiments are needed.

https://www.nature.com/articles/s41561-024-01480-8?utm_source=Live+...

https://www.nature.com/articles/d41586-024-02393-7?utm_source=Live+...

Virus spreading in Latin America may cause stillbirths and birth defects
Brazilian Ministry of Health tells doctors to closely monitor pregnant women infected with the little-known Oropouche virus
Fears over viral infection during pregnancy
The 2015-2016 outbreak of the Zika virus in Brazil caused thousands of birth defects after women were infected during pregnancy; now the country is facing the same fears with the Oropouche virus. Brazil’s health ministry has reported four cases of microcephaly — a type of reduced brain development — in newborns of infected mothers and one fetal death that might be associated with the virus. The virus is transmitted by Culicoides paraensis, a tiny midge found across the Americas. Cases of Oropouche fever have surged in Brazil since late 2022. “The cases are worrisome and a sign to be alert,” says virologist Amilcar Tanuri.

https://www.science.org/content/article/virus-spreading-in-latin-am...

Plastic Was Found Inside More Than 50% of Plaques From Clogged Arteries

Plastics are now everywhere, with tiny fragments found in several major organs of the human body, including the placenta.
Given how easily the microscopic particles infiltrate our tissues, it's vital that we learn exactly what kinds of risks they could pose to our health.
Researchers have been busy studying the effects of microplastics in mini-replicas of organs, and in mice, to get a sense of how they might impact the human body. However, the concentrations of microplastics used in those studies might not reflect people's real-world exposure, and few studies have been done in humans.

In March, a small study in Italy found shards of microplastics in fatty deposits surgically removed from patients who had an operation to open up their clogged arteries – and reported their health outcomes nearly 3 years later.

Removing fatty plaques from narrowed arteries in a procedure called a carotid endarterectomy reduces the risk of future strokes.

The team behind this recent study, led by Raffaele Marfella, a medical researcher at the University of Campania in Naples, wondered how the risk of stroke – as well as heart attacks and death – compared between patients who had microplastics in their plaques and those who did not.
Following 257 patients for 34 months, the researchers found nearly 60 percent of them had measurable amounts of polyethylene in plaques pulled from their fat-thickened arteries, and 12 percent also had polyvinyl chloride (PVC) in extracted fat deposits.

PVC comes in both rigid and flexible forms, and is used to make water pipes, plastic bottles, flooring, and packaging. Polyethylene is the most commonly produced plastic, used for plastic bags, films, and bottles, too.
Part 1

With microplastics previously found coursing through people's bloodstream, the researchers were reasonably concerned about heart health. Lab-based studies suggest microplastics can trigger inflammation and oxidative stress in heart cells, and impair heart function, alter heart rate, and cause scarring of the heart in animals such as mice.

"Observational data from occupational-exposure studies [also] suggest an increased risk of cardiovascular disease among persons who are exposed to plastics-related pollution, including polyvinyl chloride, than that seen in the general population," Marfella and colleagues write.
In the study, patients with microplastics in their excised plaques were 4.5 times as likely to have experienced a stroke, non-fatal heart attack or died from any cause after 34 months than people who had no detectable microplastics in the plaques that surgeons had removed.

The amount of microplastics, and even smaller particles called nanoplastics, was measured using a technique called pyrolysis–gas chromatography–mass spectrometry, and their presence confirmed using another method, stable isotopes analysis, which can distinguish between the carbon of human tissues and that of plastics made from petrochemicals.

Microplastics were also visible under powerful microscopes: The researchers observed plastic fragments with jagged edges inside immune cells called macrophages, and within the fatty plaques. Examining the tissue samples, the team also found higher levels of inflammatory markers in patients with microplastics in their plaques.
Part 2

Bear in mind, however, that an observational study like this can't definitively conclude that microplastics are causing the downstream heart effects; only that there is an association. The study did not consider other risk factors for cardiovascular disease, such as smoking, physical inactivity, and air pollution.
"Although we do not know what other exposures may have contributed to the adverse outcomes among patients in this study, the finding of microplastics and nanoplastics in plaque tissue is itself a breakthrough discovery that raises a series of urgent questions," such as how to reduce exposure, explained pediatrician, public health physician and epidemiologist Philip J. Landrigan, of Boston College, in an accompanying editorial.

Plastic production has exploded in the past two decades, only a fraction of which has been recycled, and yet rates of cardiovascular disease have been falling in some parts of the world, so more research is needed to understand the link between the two.

https://www.nejm.org/doi/10.1056/NEJMoa2309822

Part 3

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Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report in the Journal of Studies on Alcohol and Drugs.

Over the years, many studies have suggested that moderate drinkers enjoy longer lives with lower risks of heart disease and other chronic ills than abstainers do. That spurred the widespread belief that alcohol, in moderation, can be a health tonic. However, not all studies have painted such a rosy picture—and the new analysis sheds light on why.

In a nutshell, studies linking moderate drinking to health benefits suffer from fundamental design flaws, said lead researcher Tim Stockwell, Ph.D., a scientist with the Canadian Institute for Substance Use Research at the University of Victoria.

The major issue: Those studies have generally focused on older adults and failed to account for people's lifetime drinking habits. So moderate drinkers were compared with "abstainer" and "occasional drinker" groups that included some older adults who had quit or cut down on drinking because they'd developed any number of health conditions.

That makes people who continue to drink look much healthier by comparison, And in this case, the researchers noted, looks are deceiving.

Part 1

For the analysis,  researchers identified 107 published studies that followed people over time and looked at the relationship between drinking habits and longevity. When the researchers combined all the data, it looked like light to moderate drinkers (that is, those who drank between one drink per week and two per day) had a 14% lower risk of dying during the study period compared with abstainers.

Things changed, however, when the investigators did a deeper dive. There were a handful of "higher quality" studies that included people who were relatively young at the outset (younger than 55, on average) and that made sure former and occasional drinkers were not considered "abstainers." In those studies, moderate drinking was not linked to a longer life.

Instead, it was the "lower quality" studies (older participants, no distinction between former drinkers and lifelong abstainers) that did link moderate drinking to greater longevity.

"If you look at the weakest studies," the researchers said, "that's where you see health benefits."

Part 2

The notion that moderate drinking leads to a longer, healthier life goes back decades. As an example, the scientists pointed to the "French paradox"—the idea, popularized in the 1990s, that red wine helps explain why the French enjoy relatively low rates of heart disease, despite a rich, fatty diet. That view of alcohol as an elixir still seems to be "ingrained" in the public imagination, Stockwell noted.

In reality, they said, moderate drinking likely does not extend people's lives—and, in fact, carries some potential health hazards, including increased risks of certain cancers. That's why no major health organization has ever established a risk-free level of alcohol consumption.

"There is simply no completely 'safe' level of drinking," the researchers confirm.

Stockwell, T., et al. Why do only some cohort studies find health benefits from low volume alcohol use? A systematic review and meta-analysis of study characteristics that may bias mortality risk estimates. Journal of Studies on Alcohol and Drugs (2024). DOI: 10.15288/jsad.23-00283. www.jsad.com/doi/10.15288/jsad.23-00283

New study confirms mammal-to-mammal avian flu spread

A new study provides evidence that a spillover of avian influenza from birds to dairy cattle across several U.S. states has now led to mammal-to-mammal transmission—between cows and from cows to cats and a raccoon.

This is one of the first times that we are seeing evidence of efficient and sustained mammalian-to-mammalian transmission of highly pathogenic avian influenza H5N1.

Whole genome sequencing of the virus did not reveal any mutations in the virus that would lead to enhanced transmissibility of H5N1 in humans, although the data clearly shows mammal-to-mammal transmission, which is concerning as the virus may adapt in mammals.

So far, 11 human cases have been reported in the U.S., with the first dating back to April 2022, each with mild symptoms: four were linked to cattle farms and seven have been linked to poultry farms, including an outbreak of four cases reported in the last few weeks.

Part1

These recent patients fell ill with the same strain identified in the study as circulating in dairy cows, leading the researchers to suspect that the virus likely originated from dairy farms in the same county.

While the virus does have the ability to infect and replicate in people, the efficiency of those infections is low.

How epigenetics influence memory formation

When we form a new memory, the brain undergoes physical and functional changes known collectively as a "memory trace." A memory trace represents the specific patterns of activity and structural modifications of neurons that occur when a memory is formed and later recalled.

But how does the brain "decide" which neurons will be involved in a memory trace? Studies have suggested that the inherent excitability of neurons plays a role, but the currently accepted view of learning has neglected to look inside the command center of the neuron itself, its nucleus. In the nucleus, there seems to be another dimension altogether that has gone unexplored: epigenetics.

Inside every cell of a given living organism, the genetic material encoded by the DNA is the same, yet the various cell types that make up the body, like skin cells, kidney cells, or nerve cells each express a different set of genes. Epigenetics is the mechanism of how cells control such gene activity without changing the DNA sequence.

Now, scientists  have explored whether epigenetics might affect the likelihood of neurons to be selected for memory formation. Their research on mice, published in Science, shows that the epigenetic state of a neuron is key to its role in memory encoding.

The researchers  wondered if epigenetic factors could influence the "mnemonic" function of a neuron. A neuron can be epigenetically open when the DNA inside its nucleus is unraveled or relaxed; and closed when the DNA is compact and tight.

They found that it is the open ones that are more likely to be recruited into the "memory trace," the sparse set of neurons in the brain that shows electrical activity when learning something new. Indeed, the neurons that were in a more open chromatin state were also the ones demonstrating higher electrical activity.

The 

scientists then used a virus to deliver epigenetic enzymes to artificially induce openness of the neurons. They found that the corresponding mice learned much better. When the scientists used the opposite approach to close the neurons' DNA, the mice's ability to learn was canceled.

The findings open up new ways to understand learning that encompass the neuron's nucleus, and may even lead one day to medication for improving learning.

Giulia Santoni et al, Chromatin plasticity predetermines neuronal eligibility for memory trace formation, Science (2024). DOI: 10.1126/science.adg9982. www.science.org/doi/10.1126/science.adg9982

Fecal matter transplant helps half of patients with GI cancers overcome immunotherapy resistance

Findings from a small, proof-of-concept clinical trial have suggested that fecal microbiota transplants (FMTs) can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers.

In the study, published July 25 in the journal Cell Host & Microbe, six of 13 patients who had previously shown resistance to immune checkpoint inhibitors benefited from receiving FMTs from donors who had previously responded to treatment. The investigators also identified specific strains of bacteria associated with better or worse responses to FMT and immune checkpoint drugs.

This research highlights the complex interplay between beneficial and detrimental bacteria within the gut microbiota in determining treatment outcomes.

Immune checkpoint inhibitors have revolutionized cancer treatment, but many patients never respond or develop resistance after an initial response. The researchers decided to study FMT in patients receiving immune checkpoint inhibitors because emerging evidence suggests that the gut microbiota plays a crucial role in modulating the immune system and can significantly impact the efficacy of these therapies.

Part 1

This study is the first to show the potential benefits of this treatment in clinical settings beyond melanoma.

The trial included patients with metastatic solid-tumor cancers who were resistant to the anti-PD-1 drug nivolumab. Four had gastric cancer, five had esophageal cancer, and four had hepatocellular carcinoma.

The six FMT donors, who also had gastric cancer, esophageal cancer, or hepatocellular carcinoma, had had a complete or partial response for at least six months after treatment with nivolumab or pembrolizumab. The FMTs were given via colonoscopy after the recipients had received antibiotics to tamp down their own microbiotas.
One of the most surprising results was from a hepatocellular carcinoma patient who initially showed no response to the first FMT and continued to experience cancer progression. However, after switching the donor for the second FMT, the patient exhibited remarkable tumor shrinkage.
The investigators then took a closer look at which bacteria were most likely to affect whether patients benefited from FMT combined with checkpoint inhibitors. In doing so, they identified a novel bacterial strain that helped to improve FMT efficacy, Prevotella merdae Immunoactis.

They also identified two strains that had a detrimental impact on FMT efficacy, Lactobacillus salivarius and Bacteroides plebeius.

They plan to continue studying these and other strains with the goal of developing better ways to boost immunotherapy effectiveness by altering the gut microbiota.
By examining the complex interactions within the microbiome, the researchers hope to identify optimal microbial communities that can be used to enhance cancer treatment outcomes.
This comprehensive approach will help us understand how the microbial ecosystem as a whole contributes to therapeutic success.
Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in refractory unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor, Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.06.010. www.cell.com/cell-host-microbe … 1931-3128(24)00228-2

Fears over viral infection during pregnancy
The 2015-2016 outbreak of the Zika virus caused thousands of birth defects among Brazilians infected during pregnancy; now the country is facing the same fears with the Oropouche virus. Brazil’s health ministry has reported four cases of microcephaly — a type of reduced brain development — in newborns of infected mothers and one fetal death that might be associated with the virus. Oropouche is transmitted by Culicoides paraensis, a tiny midge found across the Americas. Cases of Oropouche fever have surged in Brazil since late 2022. The cases are worrisome and a sign to be alert.

https://www.science.org/content/article/virus-spreading-in-latin-am...

Stolen bacterial genes defeat fungus

Microscopic freshwater animals, just half a millimetre long, have perfected the trick of stealing genes from bacteria, allowing them to fight off infections and survive for millions of years without sex. These unusual creatures, bdelloid rotifers, are all females and 10% of their genes come from foreign organisms. Asexual reproduction should leave them vulnerable to pathogens but some of the ‘borrowed genes’ code for bacterial enzymes known as synthetases, w... — helping the rotifers to defeat fungal infections.

https://www.nature.com/articles/s41467-024-49919-1?utm_source=Live+...

Hungry fungi clean up contamination

A growing number of biotech companies are investing in fungal treatments that break down environmental contaminants — from.... Fungi tend to be better than bacteria at tackling large, complex chemicals like the hydrocarbons in many plastics, although this sometimes requires combining different strains of fungi to perform different steps of the process. They can be applied directly to contaminated soil or water, as well as used to break down plastic-based garbage like carpets or mattresses.

https://www.nature.com/articles/s41587-024-02315-y.epdf?sharing_tok...

Scientists figure out why there are so many colorful birds in the tropics and how these colours spread over time

The color palette of the birds you see out your window depends on where you live. If you're far from the Equator, most birds tend to have drab colors, but the closer you are to the tropics, you'll probably see more and more colorful feathers.

Scientists have long been puzzled about why there are more brilliantly-colored birds in the tropics than in other places, and they've also wondered how those brightly-colored birds got there in the first place: that is, if those colorful feathers evolved in the tropics, or if tropical birds have colorful ancestors that came to the region from somewhere else.

In a study published in the journal Nature Ecology and Evolution, scientists built a database of 9,409 birds to explore the spread of color across the globe.

They found that iridescent, colorful feathers originated 415 times across the bird tree of life, and in most cases, arose outside of the tropics– and that the ancestor of all modern birds likely had iridescent feathers, too.

There are two main ways that color is produced in animals: pigments and structures. Cells produce pigments like melanin, which is responsible for black and brown coloration. Meanwhile, structural color comes from the way light bounces off different arrangements of cell structures. Iridescence, the rainbow shimmer that changes depending how light hits an object, is an example of structural colour.

Tropical birds get their colors from a combination of brilliant pigments and structural color.

Researchers  combed through photographs, videos, and even scientific illustrations of 9,409 species of birds— the vast majority of the 10,000-ish living bird species known to science. The researchers kept track of which species have iridescent feathers, and where those birds are found.

The scientists then combined their data on bird coloration and distribution with a pre-existing family tree, based on DNA, showing how all the known bird species are related to each other. They fed the information to a modeling system to extrapolate the origins and spread of iridescence.

Given how modern species are related to each other and where they're found, and overall patterns of how species form and how traits like colors change over time, the modeling software determined the most likely explanation for the bird colors we see today: colorful birds from outside the tropics often came to the region millions of years ago, and then branched out into more and more different species. The model also revealed a surprise about the ancestor of all modern birds.

Part 1

Birds are a specialized group of dinosaurs— the earliest known bird, Archaeopteryx, lived 140 million years ago. A sub-group of birds called Neornithes evolved 80 million years ago, and this group became the only birds (and dinosaurs) to survive the mass extinction 66 million years ago.
All modern birds are members of Neornithes.The model produced by researchers now suggests that the common ancestor of all Neornithes, 80 million years ago, had iridescent feathers that still glitter across the bird family tree.
Researchers found fossil evidence of iridescent birds and other feathered dinosaurs before, by examining fossil feathers and the preserved pigment-producing structures in those feathers. So we know that iridescent feathers existed back in the Cretaceous—those fossils help support the idea from this new model that the ancestor of all modern birds was iridescent too.
The discovery that the first Neornithes was likely iridescent could have important implications for paleontology.

Transitions between colour mechanisms affect speciation dynamics and range distributions of birds, Nature Ecology & Evolution (2024). DOI: 10.1038/s41559-024-02487-5

Part 2

Ice 0: Researchers discover a new mechanism for ice formation

Ice is far more complicated than most of us realize, with over 20 different varieties known to science, forming under various combinations of pressure and temperature. The kind we use to chill our drinks is known as ice I, and it's one of the few forms of ice that exist naturally on Earth.

Researchers have recently discovered another type of ice: ice 0, an unusual form of ice that can seed the formation of ice crystals in supercooled water.

The formation of ice near the surface of liquid water can start from tiny crystal precursors with a structure similar to a rare type of ice, known as ice 0.

In a study published in Nature Communications, researchers showed that these ice 0-like structures can cause a water droplet to freeze near its surface rather than at its core. This discovery resolves a longstanding puzzle and could help redefine our understanding of how ice forms.

Crystallization of ice, known as ice nucleation, usually happens heterogeneously, or in other words, at a solid surface. This is normally expected to happen at the surface of the water's container, where liquid meets solid.

However, this new research shows that ice crystallization can also occur just below the water's surface, where it meets the air. Here, the ice nucleates around small precursors with the same characteristic ring-shaped structure as ice 0.

Simulations have shown that a water droplet is more likely to crystallize near the free surface under isothermal conditions. This resolves a longstanding debate about whether crystallization occurs more readily on the surface or internally.

Ice 0 precursors have a structure very similar to supercooled water, allowing water molecules to crystallize more readily from it, without needing to directly form themselves into the structure of regular ice.

The tiny ice 0 precursors are formed spontaneously, as a result of negative pressure effects caused by the surface tension of water. Once crystallization begins from these precursors, structures similar to ice 0 quickly rearrange themselves into the more familiar ice I.

Surface-induced water crystallization driven by precursors formed in negative pressure regions, Nature Communications (2024). DOI: 10.1038/s41467-024-50188-1

New aerospace and building materials could repair themselves thanks to fungi and bacteria

Researchers are using biological matter to create unique new materials that can adapt to their environment and repair themselves.

Researchers are developing what they call "living materials," for use in the aerospace and transportation sectors. These living materials are, precisely as they sound, literally alive. They contain microorganisms such as fungi and bacteria, which give them the capacity to sustain their integrity and self-healing.

The goal is to make engineered structures that can behave like living organisms, able to sense and adapt to mechanical stresses.

The material they are developing is a composite that combines living fungi cells and wood. It consists of a hydrogel and mycelium, a root-like structure of a fungus that normally lives underground.

They chose to work with fungi because fungus is a really robust organism, it is tolerant to harsh conditions and is relatively easy to cultivate. 

Moreover, fungal cells have a great ability to connect. Mycelium can grow a vast sensing network that allows it to send signals throughout the organism. That means the scientists can distribute only a few cells throughout the material, and these cells will reconnect and form a sensing network.

Biological materials could help to improve the performance and durability of critical structures used in areas like aerospace and transportation.

These materials are very lightweight and more sustainable than currently used materials. 

Sources: 

• AM-IMATE
• ARCHISKIN
• EU research and innovation for chemicals and advanced materials

Scientists control bacterial mutations to preserve antibiotic effectiveness

Scientists have discovered a way to control mutation rates in bacteria, paving the way for new strategies to combat antibiotic resistance.

Antibiotics are given to kill bad bacteria; however, with just one mutation a bacteria can evolve to become resistant to that antibiotic, making common infections potentially fatal.

The new research, published recently in the journal PLOS Biology, used high-performance computing to simulate more than 8,000 years of bacterial evolution, allowing scientists to predict mechanisms that control mutation rates.

They then made more than 15,000 cultures of E. coli in lab conditions to test their predictions—that's so many that if you lined up all of the bacteria in this study, they would stretch 860,000 km, or wrap around the Earth more than 20 times.

The tests revealed that bacteria living in a lowly populated community are more prone to developing antibiotic resistance due to a naturally occurring DNA-damaging chemical, peroxide. In crowded environments, where cells are more densely packed, bacteria work collectively to detoxify peroxide, reducing the likelihood of mutations that lead to antibiotic resistance.

The finding could help develop "anti-evolution drugs" to preserve antibiotic effectiveness by limiting the mutation rates in bacteria.

By understanding the environmental conditions that influence mutation rates, we can develop strategies to safeguard antibiotic effectiveness. This new study shows that bacterial mutation rates are not fixed and can be manipulated by altering their surroundings, which is vital on our journey to combat antibiotic resistance.

Peroxide, a chemical found in many environments, is key to this process. When E. coli populations become denser, they work together to lower peroxide levels, protecting their DNA from damage and reducing mutation rates. The study showed that genetically modified E. coli that is unable to break down peroxide had the same mutation rates, no matter the population size. However, when helper cells that could break down peroxide were added, the mutation rate in these genetically modified E. coli decreased.

Rowan Green et al, Collective peroxide detoxification determines microbial mutation rate plasticity in E. coli, PLOS Biology (2024). DOI: 10.1371/journal.pbio.3002711

Komodo Dragon Teeth Have Iron Caps For Sharpness, Scientists Discover

As if komodo dragons weren't amazing enough, these giant lizards literally have teeth of iron.

A new study of these formidable predators' chompers has revealed concentrated deposits of iron along the serrated tearing edges and the tips of their teeth, helping to keep them razor-sharp for tearing the flesh from the prey they devour.

Although many vertebrates have iron enhancements in their teeth, komodo dragons (Varanus komodoensis) and other similar species with serrated teeth, called ziphodonts, represent the most striking examples found to date.
In fact, so much iron is concentrated along the sharp edges of komodo teeth that they are tinted orange.

Never before has iron been found so localized along the cutting edge of a vertebrate tooth. This suggests that a stronger cutting edge confers a competitive advantage, and may yield insights into how some of the fiercest dinosaurs devoured their food.

https://www.nature.com/articles/s41559-024-02477-7

Biologists discover human-infecting parasite produces sterile soldiers like ants and termites

Neuroscientists discover brain circuitry of placebo effect for pain relief

Signs of Ancient Life on Mars?

NASA’s Perseverance rover has made very compelling observations in a Martian rock that, with further study, could prove that life was present on Mars in the distant past – but how can we determine that from a rock, and what do we need to do to confirm it? Morgan Cable, a scientist on the Perseverance team, takes a closer look.

Trees reveal climate surprise: Microbes living in bark remove methane from the atmosphere

Tree bark surfaces play an important role in removing methane gas from the atmosphere, according to a study published 24 July in Nature.

While trees have long been known to benefit the climate by removing carbon dioxide from the atmosphere, this new research reveals a surprising additional climate benefit. Microbes hidden within tree bark can absorb methane—a powerful greenhouse gas—from the atmosphere.

An international team of researchers has shown for the first time that microbes living in bark or in the wood itself are removing atmospheric methane on a scale equal to or above that of soil. They calculate that this newly discovered process makes trees 10% more beneficial for climate overall than previously thought.

Methane is responsible for around 30% of global warming since pre-industrial times and emissions are currently rising faster than at any point since records began in the 1980s.

Although most methane is removed by processes in the atmosphere, soils are full of bacteria that absorb the gas and break it down for use as energy. Soil had been thought of as the only terrestrial sink for methane, but researchers now show that trees may be as important, perhaps more so.

Vincent Gauci, Global atmospheric methane uptake by upland tree woody surfaces, Nature (2024). DOI: 10.1038/s41586-024-07592-w. www.nature.com/articles/s41586-024-07592-w

New study links brain microstructure to gender differences in mental health

A team of neuroscientists and behavioral specialists has found differences between male and female brain structure in areas associated with decision-making, memory processing and handling emotions.

In their study, published in the Proceedings of the National Academy of Sciences, the group compared more than 1,000 brain scans to better understand why men and women are more prone to different kinds of brain illness.

Prior research has shown that male babies are three times as likely to be diagnosed with autism as they grow older than are female babies—they are also twice as likely to be diagnosed with ADHD. On the other hand, female babies are almost twice as likely to be diagnosed with anxiety or mood disorders later in life than are boys.

Mental health specialists have wondered for many years why there are differences, and many suspect that it is due to physical brain differences between the genders. The research team thinks they may have found evidence for such differences.

To spot possible gender differences in the brain, the researchers focused their attention on subcortical gray matter regions that prior researchers have associated with mental health, including the amygdala and the thalamus. They then analyzed MRI scans of 1,065 male and female brains, looking for differences in brain microstructure, such as the way cells are concentrated, their arrangement or even their physical characteristics.

The research team found what they describe as "large, sex-related differences in microstructures." They noted that such changes were still apparent after adjusting for age and the relative size of the brains under study. They also found diffusion metrics in the amygdala and thalamus that they believe could be associated with mental disorders such as anxiety, ADHD, social skills issues and depression.

They suggest that further study of diffusion MRI imagery could provide more insight into gender-based brain disorders.

Richard Watts et al, Sex and mental health are related to subcortical brain microstructure, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2403212121. www.pnas.org/doi/full/10.1073/pnas.2403212121

NASA streams first 4K video from aircraft to space station and back

A team at NASA's Glenn Research Center in Cleveland has streamed 4K video footage from an aircraft to the International Space Station and back for the first time using optical (laser) communications. The feat was part of a series of tests on new technology that could provide live video coverage of astronauts on the moon during the Artemis missions.

Historically, NASA has relied on radio waves to send information to and from space. Laser communications use infrared light to transmit 10 to 100 times more data faster than radio frequency systems.

Working with the Air Force Research Laboratory and NASA's Small Business Innovation Research program, Glenn engineers temporarily installed a portable laser terminal on the belly of a Pilatus PC-12 aircraft. They then flew over Lake Erie, sending data from the aircraft to an optical ground station in Cleveland. From there, it was sent over an Earth-based network to NASA's White Sands Test Facility in Las Cruces, New Mexico, where scientists used infrared light signals to send the data.

The signals traveled 22,000 miles away from Earth to NASA's Laser Communications Relay Demonstration (LCRD), an orbiting experimental platform. The LCRD then relayed the signals to the ILLUMA-T (Integrated LCRD LEO User Modem and Amplifier Terminal) payload mounted on the orbiting laboratory, which then sent data back to Earth. During the experiments, High-Rate Delay Tolerant Networking (HDTN), a new system developed at Glenn, helped the signal penetrate cloud coverage more effectively.

After each flight test, the team continuously improved the functionality of their technology.

Source: NASA

Part 2

Blood thinner stops cobra venom
A common blood thinner can fight the toxins in cobra venom, potentially preventing limb amputations caused by snakebites. Using the genetic editing tool CRISPR, researchers found that eliminating certain sugars on the outside of human cells allowed the cells to resist cobra toxins. In experiments with mice, a class of drugs known as heparinoids soaked up the toxin and shrank venom-induced wounds by 94%. The drugs worked against several cobra species’ venoms, but not against viper venoms.

https://www.science.org/doi/10.1126/scitranslmed.adk4802?utm_source...

A passive, renewable, more efficient way to extract water from the atmosphere

Freshwater scarcity affects  billions of people in the world, primarily in arid and remote regions, as well as islands and coastal areas without freshwater sources. Climate change and population growth are only making the problem worse, and existing methods require an energy input, usually electrical.

Renewable energy can fix this and is required for these regions for drinking water and irrigation, using water extracted from the atmosphere.

It is estimated the atmosphere holds about 13 trillion tons of water, six times the freshwater in the globe's rivers; global warming allows the air to hold more water vapor, by a theoretical 7% per degree Celsius of warming.

Now engineers and scientists  have created a system that uses  solar energy to extract as much as 3 liters (0.8 gallons) of water per square meter per day from air, in a purely passive way, requiring no maintenance or human operators. The study is published in the journal Nature Communications.

Existing solar-driven atmospheric water extraction (SAWE) systems typically rely on absorbing water vapor from the air. When the absorbing material reaches saturation, the system is sealed and exposed to sunlight, which begins the release of the captured water. They are an improvement over passive atmospheric water technologies such as fog and dew collection, and more available in other geographies and sites with climate constraints.

To design a passive, efficient, easily scalable and minimal-labor system, the group used a structure of multiple vertical microchannels, called mass transport bridges. The tubes, sitting in a container, are filled with a liquid salt solution that acts as a liquid absorber; they used lithium chloride.

Depending on the temperature distribution, the ambient temperature region, exposed to the environment, continuously captures atmospheric water and stores it in a container. When the system receives sunlight, the absorber converts the light into heat and generates concentrated water vapor in the high-temperature region.

The water vapor condenses on the chamber wall, producing freshwater. More captured water from the absorber's container moves uninterrupted to the high-temperature region.

At the same time, the concentrated liquid in the high-temperature region is transported back to the ambient temperature region via diffusion—the movement of molecules from a region of high concentration to low concentration—and by convection—the movement of the hotter, lower density solution through the colder, denser regions—enabling continuous capture of water vapor as long as sunlight is available.

Kaijie Yang et al, A solar-driven atmospheric water extractor for off-grid freshwater generation and irrigation, Nature Communications (2024). DOI: 10.1038/s41467-024-50715-0