Science Simplified!

                       JAI VIGNAN

All about Science - to remove misconceptions and encourage scientific temper

Communicating science to the common people

'To make  them see the world differently through the beautiful lense of  science'

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  • Dr. Krishna Kumari Challa

    New research suggests maternal asthma may heighten risk of retinopathy of prematurity
    Maternal asthma was associated with approximately a twofold increase in risk of treatment-requiring retinopathy of prematurity in a cohort of 2,237 screened premature infants. The association appeared independent of established risk factors such as gestational age and birth weight. Findings support maternal asthma control during pregnancy as a potential strategy to reduce severe ROP risk.

    Dallin Milner et al, The Clinical Association of Maternal Asthma and the Development of Retinopathy of Prematurity in Preterm Infants, Journal of VitreoRetinal Diseases (2026). DOI: 10.1177/24741264261421789

  • Dr. Krishna Kumari Challa

    Killing cancer requires immune cells to infiltrate tumors' hostile microenvironment—sugar shields can help them break in

    Tumors create a hostile microenvironment that impairs immune and CAR-T cell function, partly via altered surface glycans and inhibitory molecules such as galectin-3. Glycoengineering CAR-T cells to express a modified glycan “sugar coat” reduces galectin-3 binding, enhances T-cell survival and communication in tumors, and prolongs antitumor activity, emphasizing resilience and microenvironment adaptation over increased cytotoxic potency.

    original article.

  • Dr. Krishna Kumari Challa

    The mysterious tooth condition affecting millions of children
    Molar incisor hypomineralisation (MIH) is a common developmental enamel defect affecting first permanent molars and often incisors, leading to weak, discolored, sensitive teeth unrelated to oral hygiene. Suspected contributors include early-life illness, antibiotics, perinatal complications, environmental factors, and genetic susceptibility. MIH cannot currently be prevented, so management focuses on fluoride, sealants, fillings, crowns, or extractions, plus aesthetic treatments in older patients. Improved diagnostic consistency and etiological research are needed to refine prevention and care.

    original article.