Fetal brain harm linked to pregnancy infection

A specific bacterial infection during pregnancy that can cause severe harm to the unborn brain has been identified for the first time, in a finding that could have huge implications for prenatal health.

Previous studies have disagreed on whether fetal exposure to Ureaplasma parvum has a detrimental effect on brain development, so newborn health specialists of Medical Research set out to determine the answer, once and for all.

Ureaplasma parvum Serovars 3 and 6 are among the most common types that are isolated in pregnancies complicated by infection/inflammation, so they tested them individually in a pre-clinical model and the results were clear.

They showed that long-term exposure to a specific subtype of Ureaplasma (parvum 6) resulted in loss of cells that are responsible for the production of myelin (the fatty sheath that insulates nerve cells in the brain).

This resulted in less myelin production and a disruption to the architecture of myelin in the brain. This sort of disruption to myelin production can have a devastating and lifelong impact on neurodevelopment, cognition and motor function.

By contrast, they also showed that exposure to another subtype of Ureaplasma (parvum 3) had little effect on neurodevelopment.

Many of the babies affected by this infection in utero are at a much higher risk of preterm birth and the chronic intensive care and inflammation associated with being born too early, the researchers say.

Dima Abdu et al, Intra-amniotic infection with Ureaplasma parvum causes serovar-dependent white matter damage in preterm fetal sheep, Brain Communications (2025). DOI: 10.1093/braincomms/fcaf182

After early-life stress, astrocytes can affect behaviour

Astrocytes in the lateral hypothalamus region of the brain, an area involved in the regulation of sleep and wakefulness, play a key role in neuron activity in mice and affect their behavior,  researchers have found.

By broadening medical science's understanding of cerebral mechanisms, the discovery could someday help in the treatment and prevention of depression in humans, the researchers say.

According to the scientific literature, early-life stress leads to a five-fold increase in the risk of developing a mental-health disorder as an adult, notably causing treatment-resistant disorders.

As brain cells, astrocytes are sensitive to variations in the blood concentration of metabolites and, in response to changes in the blood, astrocytes can modulate the extent of their interaction with neurons, their neighboring cells.

In mice, those changes are particularly responsive to the level of corticosterone, the stress hormone in the rodents' blood.

In adult mice who experienced early-life stress, researchers saw abnormally high levels of corticosterone. The impact of stress on behavior also differed according to sex. Females were less active at night, while males were hyperactive during the day.

In people with depression who have experienced a similar type of stress, these sex differences have also been observed.

 Lewis R. Depaauw-Holt et al, A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice, Nature Communications (2025). DOI: 10.1038/s41467-025-61643-y

Is this the future of food? 'Sexless' seeds that could transform farming
Scientists are tinkering with plant genes to create crops that seed their own clones, with a host of benefits for farmers.
Sacks of seeds without the sex
Agriculture is on the brink of a revolution: grain crops that produce seeds asexually. The technology — trials of which could start sprouting as early as next month — exploits a quirk of nature called apomixis, in which plants create seeds that produce clones of the parent. Apomixis could slash the time needed to create new varieties of crops, and give smallholder farmers access to affordable high-yielding sorghum (Sorghum bicolor) and cowpea (Vigna unguiculata). But before self-cloning crops can be commercialized, the technology must run the regulatory gauntlet.

https://www.nature.com/articles/d41586-025-02753-x?utm_source=Live+...