Science Simplified!

                       JAI VIGNAN

All about Science - to remove misconceptions and encourage scientific temper

Communicating science to the common people

'To make  them see the world differently through the beautiful lense of  science'

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  • Dr. Krishna Kumari Challa

    Tugs and Prods on a Cell, Not Just Its Genes, Determine Its Fate in the Human Body
    Physical pushes and pulls on a cell, not just genes, determine whether it will become part of a bone, a brain—or a deadly tumor
    The human cells in our laboratory looked mild-mannered. They were normal cells, not cancer cells, which are able to proliferate rampantly, invade nearby tissues, and ultimately can kill.

    But something disturbingly malignant occurred when we forced these cells to change their shape, stretching them by pulling on their edges. This maneuver, flattening out their rounded mounds, increased the activity of two proteins within the cells, YAP and TAZ. As the proteins peaked, our benign cells began acting cancerous, replicating uncontrollably. It was stunning to see how these changes were triggered not by gene modifications but by a physical force.
    - Scientific American
    http://www.scientificamerican.com/article/tugs-and-prods-on-a-cell-...

  • Dr. Krishna Kumari Challa

    Inducing Task-Relevant Responses to Speech in the Sleeping Brain
    Our brains sort words as we sleep
    Vigilance in slumber may explain how meaningful sounds wake a person
    •Subjects classifying spoken words continue performing the task after falling asleep
    •Movement-related brain activity in the absence of overt behavior is demonstrated
    •The sleeping brain can process spoken words in a task-dependent manner
    •Response preparation is slower in sleep than in wakefulness
    http://www.cell.com/current-biology/abstract/S0960-9822%2814%2900994-4

  • Dr. Krishna Kumari Challa

    Persistence of livestock-associated antibiotic-resistant Staphylococcus aureus among industrial hog operation workers in North Carolina over 14 days
    http://oem.bmj.com/content/early/2014/09/05/oemed-2014-102095.full
    a small study finds that drug-resistant bacteria may hang out in the noses of some workers even after four days away from work following exposure. Almost half of the tested workers continued to harbor drug-resistant bacteria two weeks after their initial exposure, perhaps due to re-exposures on the job.

  • Dr. Krishna Kumari Challa

    The study of the Cognitive Psychology shows us the following results
    It takes years of extreme hard work to become a famous scientist. Getting fame by other means is relatively easy. That is why usually ordinary people follow 'other' means to become rich and famous and don't follow the path of  science!

    But, Einstein, Curie, Tesla, Pasteur, Hawking, Edison, Turing, Feynman , Oppenheimer, Salk, Da Vinci, Freud, Chomsky
    The half-life of scientists is longer.
    There are few celebrities from Einstein's time who are as adored today.
    That is the  'quality' aspect of science.

    Celebrities-- pop stars, movie stars, models and co invest heavy amount of their resources, time and hardwork only for the fact that they can be liked and adored by their fans. This is what makes them tick. This is their living. On the other hand; professions like academicians, scientists and others don't require such empty validations from us. And they get their shared adulations from those who matters. Still they deserve more.

  • Dr. Krishna Kumari Challa

    Hacked photosynthesis could boost crop yields
    An enzyme found in algae can make plants convert carbon dioxide into sugar more efficiently.
    Photosynthesis is the crucial process by which plants convert sunlight, water and air into energy and food - and scientists from the US and UK have now taken the first step towards speeding the process up using enzymes from blue-green algae.
    This is an important breakthrough that could lead to new ways to feed the world’s growing population.
    http://www.nature.com/news/hacked-photosynthesis-could-boost-crop-y...

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    QOTD: “I think we risk becoming the best informed society that has ever died of ignorance.” -Reuben Blades

  • Dr. Krishna Kumari Challa

    Spoof Nobel prizes that honor the humor in science were handed out at Harvard University on 18th sept. 2014, celebrating the physics of stepping on a banana skin and the neuroscience behind spotting Jesus in toast.

    The 24th edition of the annual Ig Nobel Prizes were handed out to winners from across the world by genuine, if baffled, Nobel laureates in Cambridge, Massachusetts.

    The awards showcase "achievements that first make people laugh, and then make them think," said the organizers. The ceremony at Harvard's Sanders Theatre was attended by hundreds and broadcast live online.

    The winners are serious scientists whose work is generally considered only unintentionally funny.
    Japanese researchers won the physics prize for measuring the amount of friction between a shoe and a banana skin, and between a banana skin and the floor when a person steps on the discarded fruit peel.

    Scientists in China and Canada won a neuroscience prize for trying to understand what happens in the brains of people who see the face of Jesus in a piece of toast.

    The authors come from Beijing Jiaotong University's School of Computer and Information Technology, Xidian University, the Institute of Automation Chinese Academy of Sciences in Beijing, and the University of Toronto.

    Australia, Britain and the United States shared the psychology prize for collecting evidence that people who habitually stay up late are, on average, more self-admiring, manipulative and psychopathic than early risers.

    The public health prize was shared by the Czech Republic, India, Japan and the United States for investigating whether it is mentally hazardous to own a cat.

    The Czech Republic also joined Germany and Zambia in winning the biology prize for documenting that when dogs defecate and urinate, they prefer to align their body axis with Earth's north-south geomagnetic field lines.

    Italy took the art prize for measuring the relative pain people suffer while looking at an ugly rather than a pretty painting.

    The Italian government's National Institute of Statistics walked away with the economics prize for increasing the official size of its national economy by including revenue from prostitution, illegal drug sales, smuggling, and other unlawful financial transactions between willing participants, organizers said.

    India and the United States shared the medicine prize for treating "uncontrollable" nosebleeds with strips of cured pork.

    Germany and Norway won the Arctic science award for testing how reindeer react to seeing humans who are disguised as polar bears.

    And Spanish researchers took home the nutrition prize for a study titled "Characterization of Lactic Acid Bacteria Isolated from Infant Faeces as Potential Probiotic Starter Cultures for Fermented Sausages."

    The prize-winners, who travel to collect the awards at their own expense, were given 60 seconds for an acceptance speech, a time limit enforced by an eight-year-old girl.

    The ceremony also included the premiere of a mini-opera called "What's Eating You," about people who stop eating food in favor of nourishing themselves exclusively with pills.

  • Dr. Krishna Kumari Challa

    We will have to think about this:

    Radio-collar infection kills tigress in MP

    The first tigress in India to be translocated to the wild after being hand-bred was on 19th sept., 2014, found dead of an infection caused by its radio collar at the Panna Tiger Reserve in Madhya Pradesh. T4 had earlier being showcased as the biggest success story of a big-cat breeding experiment.  Can't we be careful?

    The radio-collar caused infection around her neck. Rigor mortis set in around the maggot-infested wounds. This is the second incident of collar-related infection. In the first case, we had prior information and timely action was taken to remove the collar. This time, the wound was spotted only during autopsy.

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    Computer simulations point to formamide as prebiotic intermediate in ‘Miller’ mixtures

    New Steps Shown Toward Creation of Life by Electric Charge
    Simulating a famous experiment to produce life's building blocks by jolting molecules with electricity, scientists may have found a strange new intermediate state .

    Localized electrical fields on the surface of minerals may have had a bigger part in prebiotic chemistry than has been appreciated.

    Short-range, localized electric fields on the surface of minerals may have played a part in directing the chemistry that led to the molecules of life, according to this new study. The work does provide ‘new insights into the idea that electrical discharges, for example lightning, could have played a role in the formation of prebiotic molecules on early Earth’.

    However, ‘One criticism is that the authors chose to use a somewhat reduced or hydrogen-rich mixture in their study, whereas the atmosphere on early Earth is thought to have been carbon dioxide rich, which could entail very different chemistry in the presence of an electric field. Similar studies on a more realistic prebiotic mixture could yield interesting predictions for future experiments.
    http://www.rsc.org/chemistryworld/2014/09/modelling-points-formamid...

  • Dr. Krishna Kumari Challa

    Here is another warning:
    Artificial sweeteners can trigger diabetes
    Artificial sweeteners may disrupt the body's ability to regulate blood sugar, causing metabolic changes that can be a precursor to diabetes, researchers are reporting. That is "the very same condition that we often aim to prevent" by consuming sweeteners instead of sugar, said Dr Eran Elinav, an immunologist at the Weizmann Institute of Science in Israel, at a news conference to discuss the findings. The scientists performed a multitude of experiments, mostly on mice, to back up their assertion that the sweeteners alter the microbiome, the population of bacteria that is in the digestive system.

    The different mix of microbes, the researchers contend, changes the metabolism of glucose, causing levels to rise higher after eating and to decline more slowly than they otherwise would. The findings by Dr Elinav and his collaborators in Israel, including Eran Segal, a professor of computer science and applied mathematics at Weizmann, are being published Wednesday by the journal Nature.

    Cathryn R Nagler, a professor of pathology at the University of Chicago who was not involved with the research but did write an accompanying commentary in Nature, called the results "very compelling." She noted that many conditions, including obesity and diabetes, had been linked to changes in the microbiome. "What the study suggests," she said, "is we should step back and reassess our extensive use of artificial sweeteners."
    Previous studies on the health effects of artificial sweeteners have come to conflicting and confusing findings. Some found that they were associated with weight loss; others found the exact opposite, that people who drank diet soda actually weighed more. Some found a correlation between artificial sweeteners and diabetes, but those findings were not entirely convincing: Those who switch to the products may already be overweight and prone to the disease.

    While acknowledging that it is too early for broad or definitive conclusions, Dr Elinav said he had already changed his own behaviour.

    "I've consumed very large amounts of coffee, and extensively used sweeteners, thinking like many other people that they are at least not harmful to me and perhaps even beneficial," he said. "Given the surprising results that we got in our study, I made a personal preference to stop using them."

    In the initial set of experiments, the scientists added saccharin (the sweetener in the pink packets of Sweet'N Low), sucralose (the yellow packets of Splenda) or aspartame (the blue packets of Equal) to the drinking water of 10-week-old mice. Other mice drank plain water or water supplemented with glucose or with ordinary table sugar. After a week, there was little change in the mice who drank water or sugar water, but the group getting artificial sweeteners developed marked intolerance to glucose. Glucose intolerance, in which the body is less able to cope with large amounts of sugar, can lead to more serious illnesses like metabolic syndrome and Type 2 diabetes.

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    Six Reasons Not to Worry about the Higgs Boson Destroying the Universe
    https://storify.com/AstroKatie/six-reasons-not-to-worry-about-the-h...

  • Dr. Krishna Kumari Challa

    Source diversity among journals cited in Science Times
    A content analysis of The New York Times’ Science Times section from 1998 to 2012 found evidence of increased source diversity in use of scientific journals as news sources. Science Times increased the frequency at which it cited journals, the number of different journals that it cited, and the number of disciplines represented by cited journals. The results suggest that online availability of a wide array of scientific journals has changed sourcing behaviors.

    http://pus.sagepub.com/content/early/2014/07/24/0963662514542908.ab...

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    Generation of Macroscopic Singlet States in a Cold Atomic Ensemble
    http://journals.aps.org/prl/abstract/10.1103/PhysRevLett.113.093601 Quantum Entanglement Creates New State of Matter
    Half a million ultracold atoms were linked together in the first-ever “macroscopic spin singlet” state.
    Physicists have used a quantum connection Albert Einstein called “spooky action at a distance” to link 500,000 atoms together so that their fates were entwined. The atoms were connected via “entanglement,” which means an action performed on one atom will reverberate on any atom entangled with it, even if the particles are far apart. The huge cloud of entangled atoms is the first “macroscopic spin singlet,” a new state of matter that was predicted but never before realized.

  • Dr. Krishna Kumari Challa

    Epidemiology: Mapping Ebola in wild animals for better disease control
    Identifying the regions where wild animal populations could transmit the Ebola virus should help with efforts to prepare at-risk areas for future outbreaks.
    http://elifesciences.org/content/3/e04565

    Mapping the zoonotic niche of Ebola virus disease in Africa

    Ebola virus disease (EVD) is a complex zoonosis that is highly virulent in humans. The largest recorded outbreak of EVD is ongoing in West Africa, outside of its previously reported and predicted niche. We assembled location data on all recorded zoonotic transmission to humans and Ebola virus infection in bats and primates (1976–2014). Using species distribution models, these occurrence data were paired with environmental covariates to predict a zoonotic transmission niche covering 22 countries across Central and West Africa. Vegetation, elevation, temperature, evapotranspiration, and suspected reservoir bat distributions define this relationship. At-risk areas are inhabited by 22 million people; however, the rarity of human outbreaks emphasises the very low probability of transmission to humans. Increasing population sizes and international connectivity by air since the first detection of EVD in 1976 suggest that the dynamics of human-to-human secondary transmission in contemporary outbreaks will be very different to those of the past.

    http://elifesciences.org/content/3/e04395

  • Dr. Krishna Kumari Challa

    T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity

    T cell self-tolerance is thought to involve peripheral tolerance and negative selection, involving apoptosis of autoreactive thymocytes. However, evidence supporting an essential role for negative selection is limited. Loss of Bim, a Bcl-2 BH3-only protein essential for thymocyte apoptosis, rarely results in autoimmunity on the C57BL/6 background. Mice with T cell-specific over-expression of Bcl-2, that blocks multiple BH3-only proteins, are also largely normal. The nuclear receptor Nur77, also implicated in negative selection, might function redundantly to promote apoptosis by associating with Bcl-2 and exposing its potentially pro-apoptotic BH3 domain. Here, we report that T cell-specific expression of a Bcl2 BH3 mutant transgene results in enhanced rescue of thymocytes from negative selection. Concomitantly, Treg development is increased. However, aged BH3 mutant mice progressively accumulate activated, autoreactive T cells, culminating in development of multi-organ autoimmunity and lethality. These data provide strong evidence that negative selection is crucial for establishing T cell tolerance.
    http://elifesciences.org/content/3/e03468#sthash.vBgMe7lK.dpuf

  • Dr. Krishna Kumari Challa

    Active invasion of bacteria into living fungal cells
    The rice seedling blight fungus Rhizopus microsporus and its endosymbiont Burkholderia rhizoxinica form an unusual, highly specific alliance to produce the highly potent antimitotic phytotoxin rhizoxin. Yet, it has remained a riddle how bacteria invade the fungal cells. Genome mining for potential symbiosis factors and functional analyses revealed that a type 2 secretion system (T2SS) of the bacterial endosymbiont is required for the formation of the endosymbiosis. Comparative proteome analyses show that the T2SS releases chitinolytic enzymes (chitinase, chitosanase) and chitin-binding proteins. The genes responsible for chitinolytic proteins and T2SS components are highly expressed during infection. Through targeted gene knock-outs, sporulation assays and microscopic investigations we found that chitinase is essential for bacteria to enter hyphae. Unprecedented snapshots of the traceless bacterial intrusion were obtained using cryo-electron microscopy. Beyond unveiling the pivotal role of chitinolytic enzymes in the active invasion of a fungus by bacteria, these findings grant unprecedented insight into the fungal cell wall penetration and symbiosis formation.
    http://elifesciences.org/content/3/e03007

  • Dr. Krishna Kumari Challa

    Winners of the 2014 Google Science Fair
    Ciara, Émer and Sophie were named the Grand Prize Winner and the 15-16 age category winners of our fourth annual Google Science Fair. They are some of thousands of students ages 13-18 who dared to ask tough questions like: How can we stop cyberbullying? How can I help my grandfather who has Alzheimer's from wandering out of bed at night? How can we protect the environment? And then they actually went out and answered them.
    18 finalists representing nine countries—Australia, Canada, France, India, Russia, U.K., Ukraine and the U.S.—who spent today impressing Googlers and local school students at our Mountain View, Calif. headquarters. In addition to our Grand Prize Winners, the winners of the 2014 Google Science Fair are:

    13-14 age category: Mihir Garimella (Pennsylvania, USA) for his project FlyBot: Mimicking Fruit Fly Response Patterns for Threat Evasion. Like many boys his age, Mihir is fascinated with robots. But he took it to the next level and actually built a flying robot, much like the ones used in search and rescue missions, that was inspired by the way fruit flies detect and respond to threats. Mihir is also the winner of the very first Computer Science award, sponsored by Google.
    17-18 age category: Hayley Todesco (Alberta, Canada) for her project Waste to Water: Biodegrading Naphthenic Acids using Novel Sand Bioreactors. Hayley became deeply interested in the environment after watching Al Gore’s documentary “An Inconvenient Truth.” Her project uses a sustainable and efficient method to break down pollutant substances and toxins found in tailing ponds water in her hometown, a hub of the oil sands industry.
    The Scientific American Science in Action award: Kenneth Shinozuka (Brooklyn, New York) for his wearable sensors project. Kenneth was inspired by his grandfather and hopes to help others around the world dealing with Alzheimer's. The Scientific American award is given to a project that addresses a health, resource or environmental challenge.
    Voter’s Choice award: Arsh Dilbagi (India) for his project Talk, which enables people with speech difficulties to communicate by simply exhaling.
    As the Grand Prize winners, Ciara, Émer and Sophie receive a 10-day trip to the Galapagos Islands provided by National Geographic, a $50,000 scholarship from Google, a personalized LEGO prize provided by LEGO Education and the chance to participate in astronaut training at the Virgin Galactic Spaceport in the Mojave desert.
    - Google Blog

    Teens show off inventions at Google Science Fair

    http://abc7news.com/technology/teens-show-off-inventions-at-google-...

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    'Time dilation' predicted by Einstein confirmed by lithium ion experiment.

    Physicists have verified a key prediction of Albert Einstein’s special theory of relativity with unprecedented accuracy. Experiments at a particle accelerator in Germany confirm that time moves slower for a moving clock than for a stationary one.

    The work is the most stringent test yet of this ‘time-dilation’ effect, which Einstein predicted. One of the consequences of this effect is that a person travelling in a high-speed rocket would age more slowly than people back on Earth.

    Few scientists doubt that Einstein was right. But the mathematics describing the time-dilation effect are “fundamental to all physical theories”, says Thomas Udem, a physicist at the Max Planck Institute for Quantum Optics in Garching, Germany, who was not involved in the research. “It is of utmost importance to verify it with the best possible accuracy.”

    The paper was published on September 16 in Physical Review Letters. It is the culmination of 15 years of work by an international group of collaborators including Nobel laureate Theodor Hänsch, director of the Max Planck optics institute.

    To test the time-dilation effect, physicists need to compare two clocks — one that is stationary and one that moves. To do this, the researchers used the Experimental Storage Ring, where high-speed particles are stored and studied at the GSI Helmholtz Centre for heavy-ion research in Darmstadt, Germany.
    http://www.nature.com/news/special-relativity-aces-time-trial-1.15970

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    Force of nature gave life its asymmetry

    'Left-handed' electrons destroy certain organic molecules faster than their mirror versions.
    Weak Nuclear Force Shown to Give Asymmetry to Biochemistry of Life
    "Left-handed" electrons have been found to destroy certain organic molecules faster than their mirror versions

    http://www.nature.com/news/force-of-nature-gave-life-its-asymmetry-...

  • Dr. Krishna Kumari Challa

    Cold Atom Laboratory Chills Atoms to New Lows
    Nasa's Cold Atom Laboratory (CAL) mission has succeeded in producing a state of matter known as a Bose-Einstein condensate, a key breakthrough for the instrument leading up to its debut on the International Space Station in late 2016.
    According to Nasa, a Bose-Einstein condensate (BEC) is a collection of atoms in a dilute gas that have been lowered to extremely cold temperatures and all occupy the same quantum state, in which all of the atoms have the same energy levels. At a critical temperature, atoms begin to coalesce, overlap and become synchronized. The resulting condensate is a new state of matter that behaves like a giant — by atomic standards — wave.
    "CAL's ground testbed is the coolest spot at Nasa's Jet Propulsion Laboratory at 200 nano-Kelvin (200 billionths of 1 Kelvin)," CAL Project Scientist Rob Thompson at JPL in Pasadena, California said. "Achieving Bose-Einstein condensation in our prototype hardware is a crucial step for the mission."
    While so far, the Cold Atom Laboratory researchers have created Bose-Einstein condensates with rubidium atoms, eventually they will also add in potassium. The behavior of two condensates mixing together will be fascinating for physicists to observe, especially in space.

    Besides merely creating Bose-Einstein condensates, CAL provides a suite of tools to manipulate and probe these quantum gases in a variety of ways. It has a unique role as a facility for the atomic, molecular and optical physics community to study cold atomic physics in microgravity, said David Aveline of JPL, CAL ground testbed lead.

    "Instead of a state-of-the-art telescope looking outward into the cosmos, CAL will look inward, exploring physics at the atomic scale".

    http://www.jpl.nasa.gov/news/news.php?release=2014-325

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    The Science Of Blue Light And Why You Maybe Can't Sleep At Night
    https://www.upworthy.com/the-science-of-blue-light-and-why-you-mayb...

  • Dr. Krishna Kumari Challa

    Higgs Boson to the World Wide Web: 7 Big Discoveries Made at CERN
    http://news.yahoo.com/higgs-boson-world-wide-7-big-discoveries-made...

  • Dr. Krishna Kumari Challa

    Automating Scientific Discovery
    The power of computers to juggle vast quantities of data has proved invaluable to science. In the early days, machines performed calculations that would have taken humans far too long to perform by hand. More recently, data mining has found relationships that were not known to exist—noticing, for instance, a correlation between use of a painkiller and incidence of heart attacks. Now some computer scientists are working on the next logical step—teaching machines to run experiments, make inferences from the data, and use the results to perform new experiments. In essence, they wish to automate the scientific process.

    One team of researchers, from Cornell and Vanderbilt universities and CFD Research Corporation, took a significant step in that direction when they reported last year that a program of theirs had been able to solve a complex biological problem. They focused on glycolysis, the metabolic process by which cells—yeast, in this case—break down sugars to produce energy. The team fed their algorithm with experimental data about yeast metabolism, along with theoretical models in the form of sets of equations that could fit the data.

    The team seeded the program with approximately 1,000 equations, all of which had the correct mathematical syntax but were otherwise random. The computer changed and recombined the equations and ranked the results according to which produced answers that fit the data—an evolutionary technique that has been used since the early 1990s. The key step, explains Hod Lipson, associate professor of computing and information science at Cornell, was to not only rank how the equations fit the data at any given point in the dataset, but also at points where competing models disagreed.
    Read more here:
    http://cacm.acm.org/magazines/2012/5/148614-automating-scientific-d...

  • Dr. Krishna Kumari Challa

    Cancer: How the immune system spots tumors
    The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. http://elifesciences.org/content/3/e04476#sthash.I8siNatR.dpuf

  • Dr. Krishna Kumari Challa

    Lower IQ in Children Linked to Chemical in Water
    Babies born to mothers with high levels of perchlorate during their first trimester are more likely to have lower IQs later in life, according to a new study
    Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring; Data from the Controlled Antenatal Thyroid Study.
    http://www.ncbi.nlm.nih.gov/pubmed/25057878

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    Rabies can be eliminated from around the world, say Scots scientists
    “Vaccinating dogs is the single-most effective way of eliminating rabies."
    If you can vaccinate more than 70% of dogs through sustained campaigns, it is enough to interrupt transmission in the reservoir population so that the disease if eliminated.
    That is how rabies has been purged from most industrialised countries and why South America is so close to eradicating dog-transmitted rabies from the whole American continent.
    http://news.stv.tv/scotland/294128-glasgow-university-scientists-sa...

  • Dr. Krishna Kumari Challa

    Artificial sweeteners induce glucose intolerance by altering the gut microbiota
    What makes life sweet for those of us who are counting calories is artificial sweeteners. Diet soda gives a sweet carbonated fix. A packet of artificial sweetener in your coffee or tea makes it a delicious morning dose.

    But a new study, published September 17 in Nature, found that the artificial sweetener saccharin has an unintended side effect: It alters the bacterial composition of the gut in mice and humans. The new bacterial neighborhood brings with it higher blood glucose levels, putting the humans and the murine counterparts at risk for diabetes.
    http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13793...

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

    The Nobel Prize in Physiology/Medicine 2014 was given to three people this time-divided, one half awarded to John O'Keefe, the other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain".
    The brain has a GPS-like function that enables people to produce mental maps and navigate the world — a discovery for which three scientists won the Nobel Prize in medicine this year. The findings might help scientists design tests that can pick up the very earliest signs of the mind-robbing disease, whose victims lose their spatial memory and get easily lost.

    O'Keefe discovered the first component of the brain's positioning system in 1971. He found that a certain type of nerve cell was always activated when a rat was at a certain place in a room. Other nerve cells were activated when the rat moved to another place. He demonstrated that these "place cells" were building up a map, not just registering visual input.
    In 2005, the Mosers identified another type of nerve cell — the "grid cell" — that generates a coordinate system for precise "positioning and path-finding".
    The laureates' discoveries marked a shift in scientists' understanding of how specialized cells work together to perform complex cognitive tasks. They have also opened new avenues for understanding cognitive functions such as memory, thinking and planning.

  • Dr. Krishna Kumari Challa

    The Nobel Prize in Physics 2014 was awarded jointly to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura "for the invention of efficient blue light-emitting diodes which has enabled bright and energy-saving white light sources".
    The invention of an energy source that lights up our computer and/or mobile phone screens and holds promise to brighten up the quality of life of over 1.5 billion people around the world.
    The laureates were rewarded for having invented a new energy-efficient and environment-friendly light source — the blue light-emitting diode (LED).

    According to the committee, the laureates' inventions revolutionized the field of illumination technology.

    New, more efficient, cheaper and smarter lamps are developed all the time. White LED lamps can be created in two different ways. One way is to use blue light to excite a phosphor so that it shines in red and green. When all colours come together, white light is produced.

    The laureates were rewarded for having invented a new energy-efficient and environment-friendly light source — the blue light-emitting diode (LED).

    According to the committee, the laureates' inventions revolutionized the field of illumination technology.

    New, more efficient, cheaper and smarter lamps are developed all the time. White LED lamps can be created in two different ways. One way is to use blue light to excite a phosphor so that it shines in red and green. When all colours come together, white light is produced.

    The other way is to construct the lamp out of three LEDs, red, green and blue, and let the eye do the work of combining the three colours into white.

    LED lamps are thus flexible light sources, already with several applications in the field of illumination — millions of different colours can be produced.
    The invention of the LED however will be highly beneficial and safer than older light sources. For example, fluorescent light has mercury whereas LEDs doesn't. In future, it can be used to sterilise water as we know that UV light can kill bacteria and viruses. It has been known since 1671 that to get white light, we have to combine red, green and blue light. Red and green light has been around for half a century. Now we have blue which we can effectively mix and create new white light sources.
    The LED lamp holds great promise: due to low power requirements it can be powered by cheap local solar power.

  • Dr. Krishna Kumari Challa

    ‘Virological Penicillin’ Found In Chinese Traditional Medicine
    Researchers have isolated the first compound that can directly act on viral infectious agents, an miRNA found in honeysuckle used in traditional Chinese medicine.
    Research has validated the use of honeysuckle (Lonicera japonica) to treat viral infections, showing that it contains a plant microRNA (miRNA) which directly targets influenza A viruses (IAV) including H1N1, H5N1 and H7N9. This research has been published in Cell Research.
    http://www.nature.com/cr/journal/vaop/ncurrent/full/cr2014130a.html

  • Dr. Krishna Kumari Challa

    If you are one of those who supports organic farming this news is for you to have a rethink :

    Manure fertilizer increases antibiotic resistance

    Faeces from antibiotic-free cows helps resistant bacteria to flourish in soil, puzzling researchers.

    Treating dairy cows and other farm animals with antibiotics and then laying their manure in soil can cause the bacteria in the dirt to grow resistant to the drugs. But a study now suggests that the manure itself could be contributing to resistance, even when it comes from cows that are free of antibiotics.

    The mechanism at work is not yet clear, but the finding — published on October 6 in Proceedings of the National Academy of Sciences — suggests a complex link between antibiotic use in agriculture and resistance in human pathogens.

    “Before we say anything about ‘nitrogen treatment is terrible and organic is wonderful’, we need to see what the downsides are.”

    http://www.nature.com/news/manure-fertilizer-increases-antibiotic-r...

  • Dr. Krishna Kumari Challa

    "Why Mental Rehearsals Work."
    A common theory is that mental imagery activates some of the same neural pathways involved in the actual experience, and a recent study in Psychological Science lends support to that idea. The finding helps to explain why imagined rehearsals can improve your game. The mental picture activates and strengthens the very neural circuits—even subconscious ones that control automated processes like pupil dilation—that you will need to recruit when it is time to perform.
    http://www.readcube.com/articles/10.1038/scientificamericanmind0914...

  • Dr. Krishna Kumari Challa

    The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan W. Hell and William E. Moerner "for the development of super-resolved fluorescence microscopy"/ for making "an optical microscope into a nanoscope"/ Ability to See Single Molecules .


    The Royal Swedish Academy of Sciences announced on Wednesday that for a long time, optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light.

    Helped by fluorescent molecules, the Nobel laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work has brought optical microscopy into the nano dimension.

    The prize was given "for the development of super-resolved fluorescence microscopy".

    The techniques they developed enabled extremely high resolution images to be produced using optical microscopy. Their work circumvented the problem of the ‘diffraction limit’ – the inability of light microscopy to distinguish between structures smaller than half the wavelength of visible light or about 200nm. This advance allowed nanoscale structures – including individual molecules – to be visualised within cells while they are still alive, something that isn’t possible with techniques such as electron microscopy.

  • Dr. Krishna Kumari Challa

    In India several farmers commit suicide each year. People blame this trend on failed crops, loan payment failure, multinational seeds that don't yield good results here etc. But a recent research work shows the problem from another angle .
    Pesticide use by farmers linked to high rates of depression and suicides.
    Experts say that some of the chemicals used to control pests may make matters worse by changing farmers’ brain chemistry. Recent research has linked long-term use of pesticides to higher rates of depression and suicide. Evidence also suggests that pesticide poisoning – a heavy dose in a short amount of time – doubles the risk of depression.
    The causes are complex. There “are millions, even billions, of chemical reactions that make up the dynamic system that is responsible for your mood, perceptions, and how you experience life”. Some research suggests that the chemicals that farmers and their workers spread on fields may alter some of these brain chemicals. The studies don’t prove that pesticides cause depression, but animal testing indicates that it’s possible, said Cheryl Beseler, an environmental health researcher at Colorado State University. In rat tests pesticides have altered brain cells, neurotransmitters and production of a protective acid. In France, farmers who used herbicides were nearly twice as likely to have been treated for depression than those who didn’t use herbicides, according to a study published last year. Most insecticides work by disrupting insects' nerve cells. At high enough doses, they can alter human nerve cells as well.
    http://www.environmentalhealthnews.org/ehs/news/2014/oct/pesticides...

  • Dr. Krishna Kumari Challa

    ''Morning glory clouds'' are long bands of cigar-shaped formations can stretch up to 1,000 kilometres in length. And they can only be seen reliably in one place in the world - Australia’s Gulf Country township around the Gulf of Carpenteria in northwestern Queensland, each spring.

    They look like some kind of alien wormhole, but the iconic roll shape of the cloud is actually caused by a drop in temperature, a spike in pressure and strong sea breezes. Because of these conditions, air at the front edge of the cloud is moving up rapidly, while the air at the back is dropping, rolling the cloud into a neat little cylinder. It’s been reported that up to 10 of these clouds can appear across the sky at one time, up to 2 kilometres off the ground.

    The morning glory clouds can travel at an incredible speed of 10 to 20 metres per second - that’s around 60 kilometres per hour - with new cloud continuously being formed at the leading edge while being eroded from behind. While scientists still don’t fully understand the weather conditions that lead to the clouds, they’re associated with humidity in the area and strong sea breezes across the Gulf of Carpenteria, which are the conditions that occur here each spring between late Spetember and early November.
    http://www.sciencealert.com.au/news/20140810-26303.html

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa

  • Dr. Krishna Kumari Challa