Researchers have established that variation of a gene may help protect cancer patients from developing chemotherapy-induced cognitive impairment, commonly known as ‘chemofog’ or ‘chemobrain.’ Early-stage breast cancer patients who carry a specific variation of the brain derived neurotrophic factor (BDNF) gene are less likely to develop cognitive impairment after undergoing chemotherapy, according to the findings published in Neuro-Oncology. The BDNF gene is responsible for producing a protein that controls the growth and function of nerve cells in the brain and spinal cord. Studies have shown that a reduction in blood level of BDNF—due to variation in the BDNF gene—is associated with cognitive impairment in patients with Alzheimer’s disease and other neuropsychological disorders. The finding, from a recent study led by Associate Professor Alexandre Chan and PhD candidate Mr. Terence Ng from the National University of Singapore's (NUS) Department of Pharmacy, is the first time that the BDNF gene has been associated with cognitive changes in cancer patients. The discovery can help researchers better understand the underlying mechanisms that lead to the development of this chemotherapy-induced side effect.
Background Brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal function and development, is implicated in several neurodegenerative conditions. Preliminary data suggest that a reduction of BDNF concentrations may lead to postchemotherapy cognitive impairment. The researchers hypothesized that a single nucleotide polymorphism (rs6265) of the BDNF gene may predispose patients to cognitive impairment. This study was aimed to evaluate the effect of BDNF gene polymorphism on chemotherapy-associated cognitive impairment. http://neuro-oncology.oxfordjournals.org/content/early/2015/08/18/n...
Pesticide In Milk Associated With Parkinson’s Disease: Exposure to a pineapple pesticide via milk intake has been linked to an increased incidence of Parkinson’s in Japanese men. A pesticide used prior to the early 1980s and found in milk at that time may be associated with signs of Parkinson's disease in the brain, according to a study published in Neurology.
For the study, 449 Japanese-American men with an average age of 54 who participated in the Honolulu-Asia Aging Study were followed for more than 30 years and until death, after which autopsies were performed. Tests looked at whether participants had lost brain cells in the substantia nigra area of the brain, which occurs in Parkinson's disease and can start decades before any symptoms begin. Researchers also measured in 116 brains the amount of residue of a pesticide called heptachlor epoxide. The pesticide was found at very high levels in the milk supply in the early 1980s in Hawaii, where it was used in the pineapple industry. It was used to kill insects and was removed from use in the US around that time. The pesticide may also be found in well water. The study found that non-smokers who drank more than two cups of milk per day had 40 percent fewer brain cells in that area of the brain than people who drank less than two cups of milk per day. For those who were smokers at any point, there was no association between milk intake and loss of brain cells. Previous studies have shown that people who smoke have a lower risk of developing Parkinson's disease. Residues of heptachlor epoxide were found in 90 percent of people who drank the most milk, compared to 63 percent of those who did not drink any milk. Abbott noted that the researchers do not have evidence that the milk participants drank contained heptachlor epoxide. He also stated that the study does not show that the pesticide or milk intake cause Parkinson's disease; it only shows an association. http://www.neurology.org/content/early/2015/12/09/WNL.0000000000002254
Arsenic release metabolically limited to permanently water-saturated soil Scientists have solved the mystery of where the microbes responsible for releasing dangerous arsenic into groundwater in Southeast Asia get their food. Their findings, published Nature Geosciences, could guide future land management and future development. Groundwater in South and Southeast Asia commonly contains concentrations of arsenic 20 to 100 times greater than the World Health Organization's recommended limit, resulting in more than 100 million people being poisoned by drinking arsenic-laced water in Bangladesh, Cambodia, India, Myanmar, Vietnam and China. Arsenic is bound to iron oxide compounds in rocks from the Himalayas, and gets washed down the major rivers and deposited in the lowland basins and deltas. Scientists know that in the absence of oxygen, some bacteria living in those deposited sediments can use arsenic and iron oxide particles as an alternative means of respiration. When they do this, however, the microbes separate the arsenic and iron oxides and transfer the toxin into underlying groundwater. The mystery in this system, though, is an obvious source of energy that the microbes can tap to fuel the separation process. The scientists hypothesized that bacteria residing in the shallow layers of seasonal wetlands were eating all of the digestible plant material during dry periods, when sediments are exposed to air and the microbes have access to oxygen. As a result, no food is left for the microbes when the floods returned, rendering them unable to cleave arsenic particles from iron oxides. The same experiment repeated with samples taken from about 100 feet underground—the depth of most drinking wells in Asia—showed that bacteria living deep beneath permanent and seasonal wetlands are similarly limited and and do not release arsenic into groundwater under normal conditions. The careful sleuthing has identified the bacteria in the permanent wetlands as the primary culprit of arsenic release. The work suggests that, under normal conditions, microbes in seasonal wetlands don't pose a significant threat for adding arsenic to groundwater. But what if the conditions changed ? To answer this question, the team conducted a second type of experiment, in which they simulated the conversion of a small, remote seasonal wetland into a permanent one by digging out a seasonal wetland plot and keeping it permanently filled with water. As predicted, this resulted in the release of arsenic. (The amount was small and transient and people were never threatened by the experiment.) The findings have large-scale implications for projecting changes in arsenic concentrations with land development in South and Southeast Asia and for the terrestrial carbon cycle. http://www.nature.com/ngeo/journal/vaop/ncurrent/full/ngeo2589.html
The route followed by Hepatitis C to escape our Immune System : A high proportion of hepatitis C-infected individuals develop chronic infections, suggesting that hepatitis C can subvert host antiviral responses.
The innate immune system, the body's first line of defence, is known to depend on the transcription factor nuclear factor κB (NF-κB). Its activation requires the ubiquitylation of upstream proteins including the adaptor protein NEMO (NF-κB essential modulator). Hepatitis C is one of many infectious pathogens that survive by inhibiting NF-κB signaling in host cells. Normally, the inflammatory cytokine tumor necrosis factor-α (TNF-α) induces antiviral innate immune responses by stimulating NF-κB through a cascade of signaling events. However patients with chronic hepatitis C infections have increased serum amounts of TNF-α, but have ineffective immune responses due to the inhibited NF-κB activation. The researchers hypothesized that the inhibition of TNF-α–induced NF-κB activation might be mediated by a viral protein expressed during hepatitis C infection. They used a luciferase reporter assay to screen which viral protein suppresses TNF-α–induced NF-κB activation and found that NS3 was sufficient to block NF-κB signaling in cells. Co-immunoprecipitation and immunofluorescence staining experiments showed that NS3 directly interacted with the linear ubiquitin chain assembly complex (LUBAC). More detailed domain mapping experiments showed that NS3 is bound to the ZnF-RBZ domain of HOIP (HOIL-1L–interacting protein; also known as RNF31), which is the same domain in LUBAC that binds to NEMO. To investigate the role of NS3 binding to HOIP, the researchers performed competitive coimmunoprecipitation experiments. They found that overexpression NS3 disrupted the interaction between HOIP and NEMO in a concentration-dependent manner. NS3 directly interacted with LUBAC, competed with NEMO for binding to LUBAC, and inhibited the LUBAC-mediated linear ubiquitylation of NEMO as well as the subsequent activation of NF-κB. The results highlight a novel immune evasion strategy adopted by hepatitis C to modulate host antiviral responses and enhance virus survival and persistence. http://stke.sciencemag.org/content/8/403/ra118
Dead people tell no tales — but dead people’s microbes do.
Bacteria, fungi and worms living in the soil beneath a decomposing body can help reveal the time — and place — of death, scientists report December 10 in Science.
Researchers have tracked the comings and goings of cadaver microbes before, but the new study is the most comprehensive survey yet. For months, microbial ecologist Jessica Metcalf of the University of Colorado Boulder and colleagues tallied up microbes on and near dead mice and humans.
As bodies decayed, similar microbes cropped up like clockwork, even on different soil types and during different seasons of the year, the team found. The microbes were so predictable that researchers could estimate the time of death (within a few days) of a body that had been dead for about a month.
And because telltale microbes stayed in the soil long after a body had been moved, they could offer investigators clues about potential crime scenes, the team suggests.
What causes changes in speed of Earth's rotation? Rising sea levels!
The connection is through the change in the speed of Earth’s rotation. Meltwater from glaciers not only causes sea levels to rise, but also shifts mass from the pole to the equator, which slows down the rotation. (Picture the Earth as a spinning figure skater. The skater moves his or her arms in to spin more quickly or out to slow down.) The gravity pull from the Moon also contributes to the slowdown, acting a little like a lever brake. However, the combination of these effects is not enough to explain the observations of the slowing down of Earth’s rotation: a contribution from Earth’s core must be added.
Over the past 3,000 years, the core of the Earth has been speeding up a little, and the mantle-crust on which we stand is slowing down. As a consequence of Earth rotating more slowly, the length of our days is slowly increasing. In fact, a century from now, the length of a day will have increased by 1.7 milliseconds. This may not seem like much, but note that this is a cumulative effect that adds up over time.
Based on their work reconciling these discrepancies, the scientists involved in the study are confident in predicting sea levels to the end of the 21st century. This can help to better prepare coastal towns, for example, to cope with climate change.
The findings, “Reconciling past changes in Earth’s rotation with 20th century global sea-level rise: Resolving Munk’s enigma,” were published in the Dec. 11 issue of the journal Science Advances.
The lead author of the study is Mathieu Dumberry, a professor in the Dept. of Physics at the University of Alberta.
A study, out of Duke University, analyzed the health of nearly one thousand 38-year-olds and found that some resembled people a decade older while others appeared years younger. Researchers determined this “biological age” based on health indicators such as body mass index, blood pressure and cholesterol level. The finding tapped into a mystery that has long captivated scientists and the public alike — “why some people can live to 120 with no disease, and others are already in bad shape at age 70”.
3. Irreproducibility problem; why?
Because scientists understood the problem and are trying to rectify it.
Experimental results that don’t hold up to replication have caused consternation among scientists for years, especially in the life and social sciences. In 2015 several research groups examining the issue reported on the magnitude of the irreproducibility problem. The news was not good.
Results from only 35 of 97 psychology experiments published in three major journals in 2008 could be replicated, researchers reported in August. The tumor-shrinking ability of the cancer drug sunitinib was overestimated by 45 percent on average, an analysis published in October showed . And a report in June found that, in the United States alone, an estimated $28 billion is spent annually on life sciences research that can’t be reproduced .
There are many possible reasons for the problem, including pressure to publish, data omission and contamination of cell cultures. Faulty statistics are another major source of irreproducibility, and several prominent scientific journals have set guidelines for how statistical analyses should be conducted. Very large datasets, which have become common in genetics and other fields, present their own challenges: Different analytic methods can produce widely different results, and the sheer size of big data studies makes replication difficult.
Perfect reproductions might never be possible in biology and psychology, where variability among and between people, lab animals and cells, as well as unknown variables, influences the results. But several groups, including the Science Exchange and the Center for Open Science, are leading efforts to replicate psychology and cancer studies to pinpoint major sources of irreproducibility.
Although there is no consensus on how to solve the problem, suggestions include improving training for young scientists, describing methods more completely in published papers and making all data and reagents available for repeat experiments.
4. Understanding why life got so complicated; why?
Microbes discovered in Arctic mud could be the closest relatives yet found to the single-celled ancestor that swallowed a bacterium and made life so complicated. Biologists have proposed that this swallowing event, perhaps 1.8 billion years ago, led to complex cells with membrane-wrapped organelles, the hallmark of all eukaryotes from amoebas to zebras.
Researchers discovered the new phylum of microbes, dubbed Lokiarchaeota, by screening DNA from sediment . Though no one has identified an actual cell yet, the new phylum appears to mingle genes similar to those in modern eukaryotes and genes from archaea, the sister group to bacteria. Analyses suggest the cells have dynamic structures that could have engulfed bacteria long ago. (Biologists have proposed representing that merger as a ring of life, rather than a tree.) What happened next in the tale is clearer but still a puzzle.
5. New light on Quantum Spookiness; Why?
Some loopholes no longer plague a crucial test for assessing the weirdness of quantum mechanics. Experiments reported in 2015 definitively demonstrate that the quantum world violates locality, the principle that events sufficiently separated in spacetime must be independent.
European researchers this year performed an experiment with electrons on opposite sides of a university campus, nearly 1.3 kilometers apart. In trials lasting 18 days, the team coaxed the electrons into an entangled state 245 times, reliably measuring the electrons’ spins every time. The results showed a clear nonlocal connection.
6. Epigenome effect; Why?
This yea,r Researchers cataloged how chemical modifications fold, compress and unwind the static DNA over time and how those modifications control when genes are on or off. The researchers cataloged epigenetic marks — chemical modifications either of DNA itself or proteins called histones — in more than 100 types of human cells. The epic effort revealed that gene variants associated with Alzheimer’s disease are more active in immune cells in the brain than in nerve cells as researchers had assumed. Another interesting aspect of this research:Tightly packed areas of the genome are more vulnerable to cancer-causing mutations.
Researchers using data from this project and other efforts to view the genome in 3-D have made startling discoveries . For instance, researchers found that a gene called FTO, thought to be a major genetic contributor to obesity, isn’t involved in fat production. Instead, a genetic variant hiding in the gene’s vicinity actually determines what type of fat the body builds . Disorganized DNA may be a cause of aging, researchers also discovered .
7. The discovery that Alzheimer's protein behaves like a prion; Why?
Under some conditions, an Alzheimer’s-related protein may have jumped between people, scientists reported this year. If true, that observation, the first of its kind, could recast the way scientists view the disease.
Scientists already had hints that the protein in question, amyloid-beta, behaves like an infectious prion, a misshapen protein that coaxes other proteins to misfold and spread from cell to cell. In a study reported in Nature, Collinge and colleagues found A-beta buildup in four of eight postmortem brains from people who had received growth hormone injections derived from cadavers. Because A-beta buildup is rare in relatively young people — all were between the ages of 36 and 51 — the finding suggests that the buildup might have been seeded by growth hormone contaminated with A-beta.
This result adds to evidence that prions may be behind Alzheimer’s disease as well as other neurodegenerative disorders such as Parkinson’s and Huntington’s. But some scientists caution that it’s too soon to label these disorders as prion diseases.
8. The genetics of cancer; Why?
Personalized genomics has been heralded as the next big weapon in the war on cancer. But researchers analyzing various tissue types this year, looking for mutations linked to the disease, have found that not all genetic alterations should be targeted equally.
Genetic profiles of tumors offer unprecedented opportunities for both cancer diagnostics and for doctors planning treatment. Bowel cancer tumors with mutations in the KRAS gene, for example, respond poorly to the drug cetuximab; the skin cancer drug vemurafenib works only if melanomas have a particular mutation in the BRAF gene.
But such genetic testing can be misleading if it isn’t conducted alongside tests of healthy cells from the same person. A vast analysis comparing the genetic profiles of tumors and normal tissue of more than 800 cancer patients found that nearly two-thirds of mutations in the studied tumors — many of which might be used to guide treatment — also showed up in patients’ healthy tissues . For those patients, the mutations were probably just benign variants unrelated to the cancer. Analyzing healthy tissue can also reveal whether mutations found in tumors are heritable or not, scientists say, which is important for deciding whether a cancer patient’s family should receive genetic counseling.
Complicating matters further is the fact that even mutations that have been linked to cancer will not always manifest as cancer. A study published in May examining eyelid skin discovered numerous cancer-associated mutations in normal, healthy patches of the skin . Detecting these mutations might lead to great anxiety and unnecessary, sometimes invasive treatments.As genetic testing of tumors becomes more widespread, best practices will emerge, as will a better understanding of the disease. Therefore, scientists working in the field are trying to change the way we look at cancer.
Stephen Hawking launches medal for science communication
Renowned British cosmologist Stephen Hawking on Wednesday launched an award for science communication that will bear his name.
The "Stephen Hawking Medal for Science Communication" will be awarded to those who help promote science to the public through media such as cinema, music, writing and art.
"People worldwide display an incredible appetite of scientific information... The public want to know, they want to understand."
The first medals will be awarded next summer in three different categories: the scientific, artistic and film communities.
The winners will be announced at the Starmus Festival, a gathering celebrating art and science in Spain's Canary Islands that will take place from June 27 to July 2 next year.
You are filled with bacteria, and you are covered in them. And a whole lot of them are just waiting for you to drop dead.
As soon as you die, they’ll swoop in. This week, we learned exactlyhow microbes chow downon us. A brave and strong-stomached team of scientists spent months watching dead bodies decompose, tracking all the bacteria, fungi, and worms, day by day. Forensic scientists can use this timeline, published inScience, to help determine time—and even place—of death.
Why some animals, especially those people consume contain mercury?
Here is the answer...
It is advisable for children and pregnant women not to eat too much fish. Why? Because they might contain harmful mercury!
Mercury pollution, from sources such as gold mining and power generation, ends up in the atmosphere and then the oceans, where it is transformed into methylmercury, which is as toxic as the element. Methylmercury accumulates in ocean creatures, and animals higher up in the food chain, such as tuna, tend to have higher levels of mercury. People who eat enough of those fish can experience health problems; mercury can impair development in children, infants and fetuses.
In 2012, researchers reported that methylmercury could be found in fog water along the central Californian coast. Now researchers are finding that the mercury, picked up from ocean water, is being deposited on land and accumulating in animals, from spiders to mountain lions. Starting with arthropods, wolf spiders, camel crickets and pill bugs all contained mercury. The researchers found mercury in all the arthropods, but the highest levels were in the wolf spiders, the team reported in the April Bulletin of Environmental Contamination and Toxicology. Wolf spiders are carnivorous, and they appeared to be acquiring more mercury through bioaccumulation. Other species, bigger ones, may also be affected.
Preliminary data shows high levels of mercury in deer in central California and in the mountain lions that eat them. A couple of mountain lions had mercury levels high enough that they could be experiencing health problems.
Researchers are still working to trace the path of toxic mercury from ocean waters to fog to land to animals, and on up the food chain.
But this research is a worrying sign that mercury pollution may be a much bigger problem than we realize, and one that can’t be solved by simply limiting the amount of tuna you eat.
HIV antibody infusion safely suppresses virus in infected people
A single infusion of a powerful antibody called VRC01 can suppress the level of HIV in the blood of infected people who are not taking antiretroviral therapy (ART), scientists at the US National Institutes of Health report in a paper published on 23rd Dec, 2015. The researchers also found that giving HIV-infected people VRC01 antibodies by infusing them into a vein or under the skin is safe and well tolerated, and the antibodies remain in the blood for an extended period.
The researchers found that while antibody infusions did not reduce the amount of HIV in blood cells, they reduced plasma viral load more than 10-fold in six of the eight people who were not on ART. In the two people in this group who began the study with the lowest viral loads, the antibody suppressed HIV to extremely low levels for approximately 3 weeks--as long as VRC01 was present at therapeutic concentrations. In the other four people whose HIV levels declined, their viral load fell substantially but did not reach undetectable levels. In the two people not on ART whose viral loads remained steady despite the antibody infusion, it was subsequently found that the predominant HIV strain in their bodies had been resistant to VRC01 at the outset. The antibody also did not appear to have any effect in people taking ART, whose virus was already suppressed.
New medicine to fight drug -resistant Mycobacterium tuberculosis, the bacterium responsible for causing tuberculosis (TB). Scientists from India and the US say they have discovered a group of compounds that can kill Mycobacterium tuberculosis
by disabling a major defense mechanism it uses to survive in the human body.
The study, supported by the National Institutes of Health, India’s ministry of science and technology and the Wellcome Trust-Department of Biotechnology alliance was published in ACS Chemical Biology.
These plant based compounds show tremendous promise as lead scaffolds for the development of new, anti-TB treatments. Specifically, these compounds inhibit the function of a critical enzyme responsible for survival of M. tuberculosis .
The new compounds belong to the ellipticine plant alkaloid family, which also is active in targeting cancerous cells. The active compounds have exerted a very high activity against drug-resistant M. tuberculosis strains isolated from patients of Indian origin. The new compounds have shown potent bactericidal activity against active as well as dormant form of drug-susceptible and MDR/XDR strains. http://pubs.acs.org/doi/10.1021/acschembio.5b00517
Bipolar disorder, or manic-depressive illness, causes dramatic mood shifts – often called episodes – in which the person is overly excited, extremely sad or depressed, or a mixed state of both, including irritable or explosive behavior, according to the National Institute of Mental Health, part of the National Institutes of Health.
Causes of bipolar disorder (BP) are thought to be both genetic and environmental, and researchers have long suspected that disruption in normal daily circadian rhythms, including sleep and wake cycles, can precede mood shifts. Researchers in a recent study found that those with bipolar disorder awoke later and slept longer, on average were awake fewer minutes overall, and were active for shorter periods than those without the disorder. Researchers also found that those with bipolar disorder displayed lower activity levels while awake and had greater variations in sleep and wake cycles. The findings are reported in the journal Proceedings of the National Academy of Sciences.
A team of international scientists led by UT Southwestern Medical Center and UCLA researchers have identified a dozen inherited traits related to sleep, wake, and activity cycles that are associated with severe bipolar disorder. Researchers also were able to tie the traits to specific chromosomes, providing important clues to the genetic nature of the disorder, as well as potential new avenues for prevention and treatment.
The 13 endophenotypes (biological or behavioral markers found more commonly in those with a certain disease than without) are: mean of awake duration, amplitude, Hill acrophase, interdaily stability, interdaily variability, median activity, relative amplitude, mean length of sleep bouts during the sleep period, mean number of sleep bouts during awake period, time of sleep offset, time of sleep onset, mean total minutes scored awake, and WASO (total minutes in awake bouts after sleep onset). http://www.pnas.org/content/early/2015/12/23/1513525113.abstract
Reusable launch vehicle trial in 2016 - ISRO India’s reusable launch vehicle being developed by the Indian Space Research Organisation (ISRO) is slated for trials in 2016 and will help reduce the cost of access to space in the long run, said ISRO Chairman A.S. Kiran Kumar.
The project was still in the experimental stage and the demonstration vehicle will have a range of 100 km, though eventually it will be like a space shuttle. The ISRO uses multi-stage rockets for satellite launch, but the reusable vehicle will be a single-stage rocket to start with. The single-stage rocket will have a solid propellant stored in casing. For a reusable vehicle, the casings have to be re-used or rebuilt and its evolution will hinge on cost benefits, said the ISRO chairman.
How much would you weigh on another star? The timescale of turbulence and vibration at a star's surface, based on its brightness variations, tells you its surface gravity. If stars had solid surfaces on which you could stand, then your weight would change from star to star. Here we show how much a 75-kg adult would tip the bathroom scale in the surface gravities of three stars. The sun is hotter than a sauna, but don't expect to lose weight there. You'd weigh 20 times more than on Earth. A red giant star (the far-future fate of our Sun, with a diameter about 35 times larger) has a much weaker pull at its surface, so you'd be 50 times lighter.
103rd version of Indian Science congress was inaugurated by Indian PM, Mr. Narendra Modi in Mysore on 3rd Jan., 2016. On Sunday, the opening day of the 103rd Indian Science Congress on the verdant campus of Mysore University, top foreign and Indian scientists again highlighted India’s particle physics research initiatives.
After playing a key role in international research initiatives like the Large Hadron Collider project at CERN to find the Higgs Boson, India is participating in several mega initiatives — a global nuclear fusion experiment called International Thermonuclear Experimental Reactor (ITER) in France, a Laser Interferometer Gravitational-wave Observatory (LIGO-India) and a world-class, underground India-based Neutrino Observatory (INO).
“Nearly 10 per cent of the contribution in the ITER project is from India. This will help in leapfrogging India’s nuclear fusion programme,’’ former ISRO chairman K Kasturirangan said Sunday during a talk on mega science projects being taken up by India. The ITER project, which involves the European Union, the United States, Russia, China, Japan and South Korea apart from India, will create the world’s largest confined plasma physics experiment facility in an effort to move towards full-fledged nuclear fusion plants for power generation. The reactor is scheduled to begin basic experiments by 2020 and will produce 500 MW using nominal energy inputs, Kasturirangan said.
The Rs 1,500-crore observatory for neutrinos (a subatomic particle) is planned near Theni in Tamil Nadu. LIGO-India is an international collaboration to study gravitational waves, which were incidentally first theorised in Albert Einstein’s Theory of General Relativity. Scientists from the US, UK, Germany and Australia, under the aegis of an Indian Initiative for Gravitational Observations (IndIGO), will help Indian scientists set up and operate a world-class observatory.
Reason for frothing lake... Phosphates in detergents is what causes frothing Bellandur lake in Bangalore. Based on a report by researchers from Indian Institute of Science (IISc.), Union Environment Minister Prakash Javadekar said on Thursday he would consider restrictions on detergents which were considered the primary reason for the froth that has engulfed the nearly 700-acre lake.
“I will take it up with the department concerned, to check if an alternative that is environmentally friendly and cost-effective to phosphates can be used. If we can ban diclofenac (a painkiller for cattle which was found to be the reason for the mass deaths of endangered vultures), then we can surely consult and think of a better alternative,” he said at a seminar on climate change here.
The Minister was briefed about the problems of Bellandur lake, where froth started to rise alarmingly in April 2015, and within a month, a portion of froth was even seen catching fire.
A recent report by researcher T.V. Ramachandra on the pollution in the lake, submitted to the Minister, conclusively shows that the froth appeared because of higher concentration of phosphates in the lake.
Phosphates form a major component in household detergents, and make their way to the lake through the estimated 500 million litres of sewage that flows into Bellandur and Vathur lakes. Phosphates do not disintegrate, and continue to remain in the water, which ends up being used for agriculture further downstream of the lake.
The researcher had previously said that more than 70 per cent reduction in phosphates was needed to reduce eutrophication (excessive nutrients in the lake that cause dense growth of plants, including water hyacinth) in the lake. This sort of reduction has been seen in lakes of developed countries where stringent measures on phosphates were imposed to preserve waterbodies.
On May 16, 2015, Pockets of froth on the lake caught fire, which is believed to have been caused by built-up methane in the bubbles.
High phosphate regions are when the limit reaches 4.22 to 5.76 parts per million (for drinking water, less than 0.1 ppm prescribed by the WHO)
Enhanced biological oxygen demand is when 119 to 140 parts per million (should be 30 ppm or less)
Decreased dissolved oxygen is 0 to 1.06 parts per million
Excessive phosphate encourages wild growth of algae and aquatic plants which sucks up oxygen from the lake and chokes inlets. This in turn adversely affects flora and fauna of the lake.
The periodic table has been given four new elements, changing one of science’s most fundamental pieces of knowledge.
Elements 113, 115, 117 and 118 will now be added to the table’s seventh row and make it complete, after they were verified by the International Union of Pure and Applied Chemistry on 30 December,2015. But they are yet to receive their final names or symbols.
The new elements were discovered by team from Japan, Russia and the USA, who will all get to name their own new elements. Read more
All of the four new admissions are man-made. The super-heavy elements are created by shoving lighter nuclei into each other and are found in the radioactive decay — which only exists for a tiny fraction of a second before they decay into other elements.
Graphene shows promise to efficiently filter nuclear waste
Membranes made from graphene can act as a sieve, separating protons from heavier nuclei of hydrogen isotope deuterium graphene can be used to clean up nuclear waste by filtering different isotopes of hydrogen, a new study has found.
Researchers led by Andre Geim from University of Manchester in UK demonstrated that using membranes made from graphene can act as a sieve, separating protons — nuclei of hydrogen — from heavier nuclei of hydrogen isotope deuterium.
The process could mean producing heavy water for nuclear power plants could be ten times less energy intensive, simpler and cheaper using graphene.
One of the hydrogen isotopes, deuterium, is widely used in analytical and chemical tracing technologies and, also, as heavy water required in thousands of tonnes for operation of nuclear power stations.
The heaviest isotope, tritium, is radioactive and needs to be safely removed as a byproduct of electricity generation at nuclear fission plants. Future nuclear technology is based on fusion of the two heavy isotopes. The researchers found that deuterons were not only effectively sieved out by their one atom thick membranes, but were sieved with a high separation efficiency. The discovery makes monolayers of graphene and boron nitride attractive as separation membranes to enrich mixtures of deuterium and tritium.
Furthermore, the researchers showed that the separation is fully scalable. Using chemical-vapour-deposited (CVD) graphene, they built centimetre-sized devices to effectively pump out hydrogen from a mixture of deuterium and hydrogen. The study was published in the journal Science.
A new half-solid, half-liquid material can heal itself ... A new half-solid, half-liquid adaptive material created by scientists in the US displays a number of amazing properties, including the ability to self-heal – stitching itself back together once divided – and self-stiffen back into its original shape after being compressed.
The material, called SAC – which stands for self-adaptive composite – is composed of a mass of sticky, micron-scale rubber balls that cling together to create a solid matrix. The composite is capable of healing itself repeatedly when cracked, and behaves kind of like a sponge, regaining its original form after being disturbed.
Researchers have confirmed that a toxic chemical in the fruit of the Asian lychee tree (Litchi chinensis) is responsible for outbreaks of a fatal brain sickness in children in India’s Bihar state where the fruit is commercially grown. Methylene cyclopropyl-glycine (MCPG) or hypoglycin G was detected in both semi-ripe and ripe lychee fruit by a team of virologists led by T. Jacob John at the Christian Medical College (CMC), Vellore, in Tamil Nadu. The findings were published in Current Science. The chemical is akin to another toxin methylene cyclopropylalanine (MCPA), which is found in ackee (Blighia sapida), a West Indian fruit. Both lychee and ackee come from the Sapindaceae (soapberry) family of plants. MCPG is known to cause hypoglycaemic encephalopathy, a metabolic illness that affects the brain when body sugar levels are low due to fasting or undernourishment.
Only undernourished children living near lychee orchards appeared to suffer and during May and June, when the fruit is harvested.
MCPG forms compounds with carnitine and coenzyme A and makes them less available for important metabolic reactions in the body. Both carnitine and coenzyme A are essential for fatty acid metabolism. When a person is fasting, stored glycogen is released initially for energy production. Later, body fat is mobilized and this requires breakdown of fatty acids aided by carnitine and coenzyme. When this metabolism is impaired, hypoglycaemia develops.The toxin is seen in high concentrations in the seed and semi-ripe pulp. Children who are malnourished are most vulnerable as they have low glycogen stores While MCPG was known to be present in lychee seeds, the study established its presence in the flesh of the fruits as well. Immediate treatment for victims includes administration of glucose.
Astronomers have discovered the brightest star explosion ever, a super supernova that easily outshines our entire Milky Way. An international team revealed “the most powerful supernova observed in human history” Thursday in the latest Science journal. The astronomers used a network of telescopes around the world to spot the record-breaking supernova last year.
The complication that needs to be overcome is that plants make use of gravity when planted to orient themselves (as they can't rely on being planted the right way up), so that their roots go down and their sprouts go up. Without gravity, they will tend to just stay at around the same depth and not sprout. One astronaut reported that this was simple enough to fix, however, just by plucking the ends out of the soil, pulling them to the surface, when they first sprout. From this point, the plant can orient itself using light and will continue to grow. Roots don't suffer as much, as they just grow away from the seed and avoid light (the surface), so develop relatively normally.
After this, growth is mostly normal. The resulting plants can look a little unusual because they don't have the usual drooping from gravity, so will tend to be more upright. Crew members aboard the International Space Station have been growing plants and vegetables for years in their "space garden." A space station study is helping investigators develop procedures and methods that allow astronauts to grow and safely eat space-grown vegetables.
Surprises in microgravity research are not unusual, though, and it turned out that overwatered traditional module sprouted and developed leaves about twice as fast.
The second surprising result was discovered when the root modules were unpacked on the ground. The new fertilizer being tested had a slower and more even release rate, which had helped lower the plants' accumulation of salts during ground studies. Investigators expected to see higher salt accumulation in the space modules, but the opposite occurred.
The current theory is that the extra water and larger plant uptake of fertilizer caused the root modules to remove nutrients faster and release fertilizer faster, thus preventing the salt accumulations that were observed in the slower-growing ground studies.
The space station's ability to provide on-the-spot adjustments to experiment conditions or opportunities to quickly repeat microgravity experiments with new conditions are a big plus for researchers.
Q:How can we receive digital imagery of Pluto so quickly from across the solar system?
Answer: Pluto is about 4.9 billion kilometers away from earth. The digital imagery is transmitted via wireless communication, which is based on electromagnetic radiation which travels with light speed, e.g. about 300.000 kilometers per second in the vacuum of space. Which means signals need about 4 1/2 hours to earth. It takes additional time to actually transmit all the data, but probably not too much. Five hours all in all are enough.
More than 90 percent of the heat trapped by greenhouse gas pollution since the 1970s has wound up in the oceans, and research published Monday revealed that a little more than a third of that seafaring heat has worked its way down to depths greater than 2,300 feet (700 meters). Plunged to ocean depths by winds and currents, that trapped heat has eluded surface temperature measurements, fueling claims of a “hiatus” or “pause” in global warming from 1998 to 2013. But by expanding cool water, the deep-sea heat’s impacts have been indirectly visible in coastal regions by pushing up sea levels, contributing to worsening high-tide flooding. The research, published in Nature Climate Change, was led by Lawrence Livermore National Laboratory.
Adding pollinators could boost small-farm yields Analysis shows bees, bugs could significantly increase crop production in poor-performing farms. Coaxing more bees, beetles and other pollinators to buzz around small fields could on average boost crop yields enough to close the gap between the worst and the best of these farms by almost a quarter, says agroecologist Lucas Alejandro Garibaldi of the National University of Río Negro and Argentina’s CONICET research network. To see whether improving pollination could make a noticeable difference, Garibaldi and an international network of researchers carefully used the same sampling protocols to observe 344 fields on large and small farms in Africa, Asia and South America over the course of five years. Looking at 33 crops that need pollinators — raspberries, apples, coffee and so on — the researchers monitored pollinator visits and diversity as well as the ultimate yields.
The low-yielding farms on average produced only 47 percent of the yield that the best did, a notable gap. On the small operations, the sheer density of pollinators visiting crop flowers made a bigger difference in the amount of food produced, the researchers found. On larger farms, pollinator diversity mattered more: Those farms with a greater variety of pollinators produced more food. Analyzing the way yields responded to the number of pollinators shows that improving pollination could help close the yield gap, Garibaldi and his colleagues say in the Jan. 22 Science.
When you see a bad moon rising, expect an ever-so-slightly wetter day. The lunar gravitational pull imperceptibly boosts rainfall when the moon is on the horizon and somewhat reduces rainfall when the moon is overhead or on the opposite side of the Earth, a new analysis of global rainfall concludes.
The cause is the atmospheric equivalent of ocean tides, researchers propose in a paper to be published in Geophysical Research Letters. Air gathers on Earth’s moon-facing side and on the opposite end of the globe. Scientists noticed that this pileup increases atmospheric pressure and predicted that atmospheric tides could alter precipitation rates as well. Scouring 15 years of global precipitation data, the researchers have discovered that the effect is present, but tiny: an approximately one micrometer per hour change in rainfall rate. The moon’s gravitational pull, which is responsible for ocean tides, also creates atmospheric tides. As more air gathers during atmospheric high tide, atmospheric pressure increases. Satellites now offer global coverage of where and when rain falls.
The data revealed that during atmospheric high tide, rising air pressure slightly increases air temperature. That temperature boost allows the air to hold more water vapor, lowering the relative humidity and making rain less likely. During low tide, pressures drop slightly, cooling the air, raising the relative humidity and making rain more likely. This effect amounts to about a hundredth that of the typical background weather variability.
Understanding the lunar influence on rainfall won’t change how we predict the weather. The effect is so small that it quickly disappears into the background noise with time.
- Science News.Org
Researchers inferred Planet X's presence from the peculiar clustering of six previously known objects that orbit beyond Neptune.
They say there's only a 0.007% chance, or about one in 15,000, that the clustering could be a coincidence.
Instead, they say, a planet with the mass of 10 Earths has shepherded the six objects into their strange elliptical orbits, tilted out of the plane of the solar system.
The editors of the leading medical journals around the world made a proposal recently that could change medical science forever. They said that researchers would have to publicly share the data gathered in their clinical studies as a condition of publishing the results in the journals. This idea is now out for public comment.
As it stands now, medical scientists can publish their findings without ever making available the data upon which their conclusions were based.
Only some of the top journals, such as The BMJ, have tried to make data sharing a condition of publication. But authors who didn't want to comply could just go elsewhere.
Think about it. The scientists who generate the data, with the participation of the people being studied and often with public funding, control it and most often don't share. By holding the data tight, researchers who ran a study are the only ones who can conduct additional analysis and studies.
If the proposed change is adopted it would make sharing more compelling. Inaccessible data is a problem rife throughout medical science. Industry traditionally held its data close — but so did academics.
These researchers have felt that they deserved the right to future papers for all their hard work gathering the original data. And maybe they didn't want others examining their work.
But this practice shields data from scrutiny. It forgoes an opportunity to crowdsource knowledge from scientists who weren't associated with the original study. It also violates the sensible practice of showing your work, not just the presumed answer. The editors who made the proposal sought to be sensitive to the rights of researchers, funders and participants. But their intent is clear: It's time to share. http://www.npr.org/sections/health-shots/2016/01/26/464010931/journ...
Tenacious proteins similar to those implicated in Alzheimer’s disease could help purify polluted water.
A newly designed membrane uses thin amyloid protein fibers to pull heavy metals and radioactive wastes out of water. The membranes can capture more than their own weight in some contaminants, scientists in Switzerland report January 25 in Nature Nanotechnology. Specifically, the team converted milk proteins into fibers of durable amyloid protein. Other amyloids are infamous for building up in the brains of Alzheimer’s patients, but the team put their amyloids’ sticky tendrils to different use.
When paired with strong, porous carbon in a membrane, the lab-made amyloids successfully filtered over 99 percent of toxic materials out of solutions that mimicked severely polluted waters, the scientists report. The amyloids trapped particles of lead and mercury at a molecular site that is involved in turning the original milk protein into its pasty form. Radioactive waste particles also got tangled in the membranes. And the membranes snagged gold contaminants, which the team found could later be recovered and purified. A membrane with less than 6 milligrams of amyloids could trap 100 milligrams of gold, the scientists report.
The membranes could be developed for small- or large-scale water purification units, says study coauthor Raffaele Mezzenga, a physicist at ETH Zurich. Mezzenga estimates the technology would cost roughly one dollar per every thousand liters of water filtered. And a membrane can recover hundreds of times its own value in precious metals, Mezzenga says. The membrane design is simple and flexible, and could be adjusted to optimize cleanup or metal recovery, he says. http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2015.3...
A new global analysis of seafood found that fish populations throughout the world's oceans are contaminated with industrial and agricultural pollutants, collectively known as persistent organic pollutants (POPs). The study from researchers at Scripps Institution of Oceanography at UC San Diego also uncovered some good news?concentrations of these pollutants have been consistently dropping over the last 30 years. The findings, reported in the Jan. 28, 2016 issue of the journal PeerJ, were based on an analysis by Scripps researchers Lindsay Bonito, Amro Hamdoun, and Stuart Sandin of hundreds of peer-reviewed articles from 1969-2012. The pollutants studied included older 'legacy' chemicals, such as DDT and mercury, as well as newer industrial chemicals, such as flame retardants and coolants. Although POPs were found in fish in all of the world's oceans, the researchers say that concentrations in the consumable meat of marine fish are highly variable, where one region or group of fish may find concentrations of POPs that vary by 1,000-fold. The analysis revealed that average concentrations of each class of POP were significantly higher in the 1980s than is found today, with a drop in concentration of 15-30 percent per decade.
"This means that the typical fish that you consume today can have approximately 50 percent of the concentration of most POPs when compared to the same fish eaten by your parents at your age," said Bonito, the lead author of the study. "But there still remains a chance of getting a fillet as contaminated as what your parents ate. The authors caution that although pollutant concentrations in marine fish are steadily declining, they still remain quite high, and that understanding the cumulative effects of numerous exposures to pollutants in seafood is necessary to determine the specific risk to consumers.
Source: University of California - San Diego
and Science news
Electrons do not orbit around an atomic nucleus like planets around a star. This outdated model of the atom (called the Bohr-Rutherford model) is still taught in schools, but only as an introduction to modern ideas about the atom.
Max Born showed us that electrons do not have a definite position, but instead exist as probability wave functions that describe how likely it is that the electron would be at a particular point in its atomic orbit. That is to say, the electron exists in a superposition of all possible locations around the atom. Werner Heisenberg discovered that it isn't until an electron is observed (detected by an instrument) that its wave function collapses and it takes on a discrete location.
So, really, electrons do not orbit around a nucleus; they exist in all possible locations around that nucleus simultaneously. Quantum mechanics!
Electrons don't orbit around atomic nucleuses like planets around a star. But that doesn't mean that they aren't moving.
The probability density for an electron is symmetric around the nucleus, so the average velocity would cancel out to zero. So let's calculate a typical speed from the square-root of the average velocity squared instead. (This is the referred to as root-mean-squared or r.m.s. for short.)
It's actually pretty easy to figure out the r.m.s. velocity for a typical electron from a few physics facts.
First, we need to the know the binding energy of the electron to the nucleus. We might as well assume it's in hydrogen, the simplest atom, so it has total binding energy of E = -13.6 eV (electron-volts):
Next, we need to know what part of the energy is kinetic (moving) instead of potential (due to the electric force holding the atom together). For closed orbits (electrons or planets), there is very handy relationship known as the Virial Theorem [1]. The Virial Theorem tells us that for particles experiencing an attractive 1/r21/r2 force like that between opposite charges, the average kinetic energy is equal to the negative of the total energy: ⟨T⟩=−E⟨T⟩=−E.
To calculate the r.m.s. velocity, we just need the non-relativistic [2] formula relating kinetic energy T and velocity v: T=12mv2T=12mv2,
where m is the mass of the object.
Solving the above equations, we find: vrms=−2Em−−−−√.vrms=−2Em.
Plugging in the binding energy and mass of an electron, we see that our hypothetical electron is moving at 2.2*10^6 m/s [3] or just shy of 5 million mph. Fast, but still about a factor of 100 times slower than the limit, the speed of light.
Till now we are under the impression that earthworms are highly beneficial to plants. But listen to this: Earthworms not always beneficial, may threaten plant diversity!
A new study suggests that an abundance of earthworms in soils could lead to reductions in the number of trees and and other plant species.
Contrary to the popular belief that these creatures and beneficial to the natural ecosystem, the scarcity of these invertebrates can be a threat to certain plant species, causing adverse effects on the ecosystem.
Researchers from Canada's Université Laval and Université de Sherbrooke visited sugar maple forests in Quebec province where they found half of which were populated by earthworms.
Their analysis revealed a correlation between the number of earthworms and the abundance and diversity of certain understory species as they found that new shoots of red maple, striped maple, American beech, and two fern species became rarer as populations of these invertebrates increased.
"The most likely explanation is that the earthworms consume organic matter in forest litter," said Line Lapointe, a professor at Université Laval's faculty of science and engineering and the study's lead author.
"This results in soils that can't hold as much moisture, and that in turn interferes with seed germination and the ability of some species' plantlets to survive," she added.
Earthworms have started to change plant composition in sugar maple forests, according to the researchers.
Researchers suggest that earthworms used for bait should never be released in the forest, instead they be thrown into the lake to avoid overpopulation in the ecosystem.
The study has been published in the journal Forest Ecology and Management.
New evidence emerges for 'transmissible Alzheimer's' theory: Autopsies reveal plaques in the brains of people who died after receiving grafts from cadavers.
For the second time in four months, researchers have reported autopsy results that suggest Alzheimer’s disease might occasionally be transmitted to people during certain medical treatments — although scientists say that neither set of findings is conclusive. The latest autopsies, described in the Swiss Medical Weekly1 on 26 January, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt–Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater — the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.
But in addition to the damage caused by the prions, five of the brains displayed some of the pathological signs that are associated with Alzheimer’s disease, researchers from Switzerland and Austria report. Plaques formed from amyloid-β protein were discovered in the grey matter and blood vessels. The individuals, aged between 28 and 63, were unusually young to have developed such plaques. A set of 21 controls, who had not had surgical grafts of dura mater but died of sporadic CJD at similar ages, did not have this amyloid signature. According to the authors, it is possible that the transplanted dura mater was contaminated with small ‘seeds’ of amyloid-β protein — which some scientists think could be a trigger for Alzheimer’s — along with the prion protein that gave the recipients CJD. http://www.smw.ch/content/smw-2016-14287/ http://www.nature.com/news/autopsies-reveal-signs-of-alzheimer-s-in...
UK scientists just got approval to edit human embryos Scientists in Britain just got approval to conduct research that involves editing the genetic material of healthy human embryos.
This is a big deal: The UK's Human Fertilisation and Embryology Authority is the first government agency in the world to endorse research that involves altering the human genome for research — a move that could signal broader acceptance for a promising (but controversial) new area of science.
The research team, led by Dr. Kathy Niakan at the UK's Francis Crick Institute, is trying to better understand which genes allow a healthy human embryo to develop. Niakan’s team will use a promising new technique, known as CRISPR/Cas9, to edit genes that are active following conception. They'll then stop the experiments at day seven and destroy the embryos (so that they can't be used to start a pregnancy).
The hope is that this gene hacking could help researchers better understand what causes miscarriages and infertility — and perhaps one day lead to better treatments for infertility.
Small ponds produce an outsized share of greenhouse gases Tiny ponds play a disproportionately large role in global greenhouse gas emissions from inland waters, according to a new study by Yale's School of Forestry & Environmental Studies.
The reason has to do with the physical makeup of very small ponds and the way they cycle carbon. Small ponds have a high perimeter-to-surface-area ratio, for example, and accumulate a higher load of terrestrial carbon -- so-called "leaf litter," sediment particles and other material. Small ponds also tend to be shallow, which means their terrestrial carbon loads are highly concentrated compared to larger lakes. Lastly, gases produced at the bottom of these ponds are able to reach the top more often than what occurs in larger lakes, due to greater water mixing and shallower waters. Because of this, CO2 and CH4 generated in sediments affects the entire pond.
That makes small ponds an important player in the carbon cycle. The carbon cycling that happens in freshwater systems needs to be accounted for in estimates of terrestrial production. These numbers are important to quantifying the global carbon cycle and making predictions about future stocks and flows of carbon.
Although ponds less than a quarter of an acre in size make up only 8.6% of the surface area of the world's lakes and ponds, they account for 15.1% of carbon dioxide (CO2) emissions and 40.6% of diffusive methane (CH4) emissions. The findings appear in the Feb. 1 online edition of the journal Nature Geoscience.
Chromosomes must be accurately segregated during the production of sex cells to ensure that the next generation inherits an intact copy of the genome. However, this process is particularly error-prone in women and gets worse as they get older. Errors in chromosome segregation produce egg cells with the wrong number of chromosomes, which can lead to infertility and Down syndrome . New eggs develop from immature egg cells (or oocytes) via meiosis: this process involves the original cell’s DNA being replicated once before it divides twice to produce four new cells, each with half the original number of chromosomes. Most errors in the number of chromosomes in human eggs come from mistakes made when the oocyte divides for the first time in a process commonly called meiosis I. Multiple factors can contribute to these errors, but it is not clear which are most significant in human oocytes. Human oocytes start with 23 pairs of homologous chromosomes, which are split during the anaphase stage of meiosis I so that the egg contains one from each pair. There are two main requirements that must be met during meiosis I. First, each pair of homologous chromosomes must be physically connected to form a “bivalent”. Second, the two sister kinetochores on each chromosome must be functionally fused together so that both sisters connect to the same spindle pole. These two requirements are both compromised in human oocytes. This provides a plausible mechanism to explain the errors often seen in meiosis I in women. -elifesciences.org
Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study Lung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). Now scientists say association between textile dust exposure and the risk of RA in the Malaysian population is real whose correctness has been established with a focus on women who rarely smoke.
Results of the study: Occupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).
Conclusions of the study: This is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA. http://ard.bmj.com/content/early/2015/11/08/annrheumdis-2015-208278...
Ocean acidification and warming could affect the culturing of pearls Pearl aquaculture is big business, particularly in Asia and Australia. But much of it takes place in oceans, which are susceptible to the increasing amounts of carbon dioxide human activity releases into the atmosphere. CO2 from the air gets absorbed by the oceans, which become more acidic as a result. Research has found that pearl oysters produce weaker shells under these conditions, and this could hurt their chances of survival. But in addition to acidity, rising water temperature could also play a role in oyster health.
- Environmental Science & Technology
Mothers who are obese during pregnancy have almost twice the odds of having a child with autism as women who weigh less, a U.S. study suggests. When women are both obese and have diabetes, the autism risk for their child is at least quadrupled, researchers reported online January 29 in Pediatrics.
Dr. Krishna Kumari Challa
Researchers have established that variation of a gene may help protect cancer patients from developing chemotherapy-induced cognitive impairment, commonly known as ‘chemofog’ or ‘chemobrain.’ Early-stage breast cancer patients who carry a specific variation of the brain derived neurotrophic factor (BDNF) gene are less likely to develop cognitive impairment after undergoing chemotherapy, according to the findings published in Neuro-Oncology. The BDNF gene is responsible for producing a protein that controls the growth and function of nerve cells in the brain and spinal cord. Studies have shown that a reduction in blood level of BDNF—due to variation in the BDNF gene—is associated with cognitive impairment in patients with Alzheimer’s disease and other neuropsychological disorders. The finding, from a recent study led by Associate Professor Alexandre Chan and PhD candidate Mr. Terence Ng from the National University of Singapore's (NUS) Department of Pharmacy, is the first time that the BDNF gene has been associated with cognitive changes in cancer patients.
The discovery can help researchers better understand the underlying mechanisms that lead to the development of this chemotherapy-induced side effect.
Background Brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal function and development, is implicated in several neurodegenerative conditions. Preliminary data suggest that a reduction of BDNF concentrations may lead to postchemotherapy cognitive impairment. The researchers hypothesized that a single nucleotide polymorphism (rs6265) of the BDNF gene may predispose patients to cognitive impairment. This study was aimed to evaluate the effect of BDNF gene polymorphism on chemotherapy-associated cognitive impairment.
http://neuro-oncology.oxfordjournals.org/content/early/2015/08/18/n...
Dec 16, 2015
Dr. Krishna Kumari Challa
Pesticide In Milk Associated With Parkinson’s Disease: Exposure to a pineapple pesticide via milk intake has been linked to an increased incidence of Parkinson’s in Japanese men.
A pesticide used prior to the early 1980s and found in milk at that time may be associated with signs of Parkinson's disease in the brain, according to a study published in Neurology.
For the study, 449 Japanese-American men with an average age of 54 who participated in the Honolulu-Asia Aging Study were followed for more than 30 years and until death, after which autopsies were performed. Tests looked at whether participants had lost brain cells in the substantia nigra area of the brain, which occurs in Parkinson's disease and can start decades before any symptoms begin. Researchers also measured in 116 brains the amount of residue of a pesticide called heptachlor epoxide. The pesticide was found at very high levels in the milk supply in the early 1980s in Hawaii, where it was used in the pineapple industry. It was used to kill insects and was removed from use in the US around that time. The pesticide may also be found in well water. The study found that non-smokers who drank more than two cups of milk per day had 40 percent fewer brain cells in that area of the brain than people who drank less than two cups of milk per day. For those who were smokers at any point, there was no association between milk intake and loss of brain cells. Previous studies have shown that people who smoke have a lower risk of developing Parkinson's disease. Residues of heptachlor epoxide were found in 90 percent of people who drank the most milk, compared to 63 percent of those who did not drink any milk. Abbott noted that the researchers do not have evidence that the milk participants drank contained heptachlor epoxide. He also stated that the study does not show that the pesticide or milk intake cause Parkinson's disease; it only shows an association.
http://www.neurology.org/content/early/2015/12/09/WNL.0000000000002254
Dec 16, 2015
Dr. Krishna Kumari Challa
Arsenic release metabolically limited to permanently water-saturated soil
Scientists have solved the mystery of where the microbes responsible for releasing dangerous arsenic into groundwater in Southeast Asia get their food. Their findings, published Nature Geosciences, could guide future land management and future development. Groundwater in South and Southeast Asia commonly contains concentrations of arsenic 20 to 100 times greater than the World Health Organization's recommended limit, resulting in more than 100 million people being poisoned by drinking arsenic-laced water in Bangladesh, Cambodia, India, Myanmar, Vietnam and China. Arsenic is bound to iron oxide compounds in rocks from the Himalayas, and gets washed down the major rivers and deposited in the lowland basins and deltas. Scientists know that in the absence of oxygen, some bacteria living in those deposited sediments can use arsenic and iron oxide particles as an alternative means of respiration. When they do this, however, the microbes separate the arsenic and iron oxides and transfer the toxin into underlying groundwater. The mystery in this system, though, is an obvious source of energy that the microbes can tap to fuel the separation process.
The scientists hypothesized that bacteria residing in the shallow layers of seasonal wetlands were eating all of the digestible plant material during dry periods, when sediments are exposed to air and the microbes have access to oxygen. As a result, no food is left for the microbes when the floods returned, rendering them unable to cleave arsenic particles from iron oxides.
The same experiment repeated with samples taken from about 100 feet underground—the depth of most drinking wells in Asia—showed that bacteria living deep beneath permanent and seasonal wetlands are similarly limited and and do not release arsenic into groundwater under normal conditions. The careful sleuthing has identified the bacteria in the permanent wetlands as the primary culprit of arsenic release. The work suggests that, under normal conditions, microbes in seasonal wetlands don't pose a significant threat for adding arsenic to groundwater. But what if the conditions changed ?
To answer this question, the team conducted a second type of experiment, in which they simulated the conversion of a small, remote seasonal wetland into a permanent one by digging out a seasonal wetland plot and keeping it permanently filled with water. As predicted, this resulted in the release of arsenic. (The amount was small and transient and people were never threatened by the experiment.) The findings have large-scale implications for projecting changes in arsenic concentrations with land development in South and Southeast Asia and for the terrestrial carbon cycle.
http://www.nature.com/ngeo/journal/vaop/ncurrent/full/ngeo2589.html
Dec 16, 2015
Dr. Krishna Kumari Challa
The route followed by Hepatitis C to escape our Immune System :
A high proportion of hepatitis C-infected individuals develop chronic infections, suggesting that hepatitis C can subvert host antiviral responses.
The innate immune system, the body's first line of defence, is known to depend on the transcription factor nuclear factor κB (NF-κB). Its activation requires the ubiquitylation of upstream proteins including the adaptor protein NEMO (NF-κB essential modulator). Hepatitis C is one of many infectious pathogens that survive by inhibiting NF-κB signaling in host cells. Normally, the inflammatory cytokine tumor necrosis factor-α (TNF-α) induces antiviral innate immune responses by stimulating NF-κB through a cascade of signaling events. However patients with chronic hepatitis C infections have increased serum amounts of TNF-α, but have ineffective immune responses due to the inhibited NF-κB activation. The researchers hypothesized that the inhibition of TNF-α–induced NF-κB activation might be mediated by a viral protein expressed during hepatitis C infection. They used a luciferase reporter assay to screen which viral protein suppresses TNF-α–induced NF-κB activation and found that NS3 was sufficient to block NF-κB signaling in cells. Co-immunoprecipitation and immunofluorescence staining experiments showed that NS3 directly interacted with the linear ubiquitin chain assembly complex (LUBAC). More detailed domain mapping experiments showed that NS3 is bound to the ZnF-RBZ domain of HOIP (HOIL-1L–interacting protein; also known as RNF31), which is the same domain in LUBAC that binds to NEMO. To investigate the role of NS3 binding to HOIP, the researchers performed competitive coimmunoprecipitation experiments. They found that overexpression NS3 disrupted the interaction between HOIP and NEMO in a concentration-dependent manner. NS3 directly interacted with LUBAC, competed with NEMO for binding to LUBAC, and inhibited the LUBAC-mediated linear ubiquitylation of NEMO as well as the subsequent activation of NF-κB. The results highlight a novel immune evasion strategy adopted by hepatitis C to modulate host antiviral responses and enhance virus survival and persistence.
http://stke.sciencemag.org/content/8/403/ra118
Dec 16, 2015
Dr. Krishna Kumari Challa
Dead people tell no tales — but dead people’s microbes do.
Bacteria, fungi and worms living in the soil beneath a decomposing body can help reveal the time — and place — of death, scientists report December 10 in Science.
Researchers have tracked the comings and goings of cadaver microbes before, but the new study is the most comprehensive survey yet. For months, microbial ecologist Jessica Metcalf of the University of Colorado Boulder and colleagues tallied up microbes on and near dead mice and humans.
As bodies decayed, similar microbes cropped up like clockwork, even on different soil types and during different seasons of the year, the team found. The microbes were so predictable that researchers could estimate the time of death (within a few days) of a body that had been dead for about a month.
And because telltale microbes stayed in the soil long after a body had been moved, they could offer investigators clues about potential crime scenes, the team suggests.
http://www.sciencemag.org/content/early/2015/12/09/science.aad2646
Dec 16, 2015
Dr. Krishna Kumari Challa
What causes changes in speed of Earth's rotation? Rising sea levels!
The connection is through the change in the speed of Earth’s rotation. Meltwater from glaciers not only causes sea levels to rise, but also shifts mass from the pole to the equator, which slows down the rotation. (Picture the Earth as a spinning figure skater. The skater moves his or her arms in to spin more quickly or out to slow down.) The gravity pull from the Moon also contributes to the slowdown, acting a little like a lever brake. However, the combination of these effects is not enough to explain the observations of the slowing down of Earth’s rotation: a contribution from Earth’s core must be added.
Over the past 3,000 years, the core of the Earth has been speeding up a little, and the mantle-crust on which we stand is slowing down. As a consequence of Earth rotating more slowly, the length of our days is slowly increasing. In fact, a century from now, the length of a day will have increased by 1.7 milliseconds. This may not seem like much, but note that this is a cumulative effect that adds up over time.
Based on their work reconciling these discrepancies, the scientists involved in the study are confident in predicting sea levels to the end of the 21st century. This can help to better prepare coastal towns, for example, to cope with climate change.
The findings, “Reconciling past changes in Earth’s rotation with 20th century global sea-level rise: Resolving Munk’s enigma,” were published in the Dec. 11 issue of the journal Science Advances.
The lead author of the study is Mathieu Dumberry, a professor in the Dept. of Physics at the University of Alberta.
Dec 17, 2015
Dr. Krishna Kumari Challa
Confirmation bias is bad for science. For example consider this conversation between an alchemist and a scientist:
Alchemist: "Hoo doo woodoo doo!" (Mixes an element to form a compound while waving his hands mystically)
Scientist: "What're you doing?"
Alchemist: "I'm making a healing salve."
Scientist: "You don't need to wave your arms about, mixing those chemicals is all you need to do to make a local anaesthetic."
Alchemist: "But I waved my arms and it worked!"
Scientist: "Really?"
Alchemist: "Yes, my waving hands has magical influence that makes the drug work!"
Scientist: This is ignorance at its best!
This is what we call confirmation bias. We look for the things that fit our idea of how things work.
Dec 17, 2015
Dr. Krishna Kumari Challa
This year's top science stories:
1. Gene-editing; why? Read it here:
http://kkartlab.in/group/some-science/forum/topics/crispr-cas9-gene...
2. Biological aging; why?
A study, out of Duke University, analyzed the health of nearly one thousand 38-year-olds and found that some resembled people a decade older while others appeared years younger. Researchers determined this “biological age” based on health indicators such as body mass index, blood pressure and cholesterol level. The finding tapped into a mystery that has long captivated scientists and the public alike — “why some people can live to 120 with no disease, and others are already in bad shape at age 70”.
3. Irreproducibility problem; why?
Because scientists understood the problem and are trying to rectify it.
Experimental results that don’t hold up to replication have caused consternation among scientists for years, especially in the life and social sciences. In 2015 several research groups examining the issue reported on the magnitude of the irreproducibility problem. The news was not good.
Results from only 35 of 97 psychology experiments published in three major journals in 2008 could be replicated, researchers reported in August. The tumor-shrinking ability of the cancer drug sunitinib was overestimated by 45 percent on average, an analysis published in October showed . And a report in June found that, in the United States alone, an estimated $28 billion is spent annually on life sciences research that can’t be reproduced .
There are many possible reasons for the problem, including pressure to publish, data omission and contamination of cell cultures. Faulty statistics are another major source of irreproducibility, and several prominent scientific journals have set guidelines for how statistical analyses should be conducted. Very large datasets, which have become common in genetics and other fields, present their own challenges: Different analytic methods can produce widely different results, and the sheer size of big data studies makes replication difficult.
Perfect reproductions might never be possible in biology and psychology, where variability among and between people, lab animals and cells, as well as unknown variables, influences the results. But several groups, including the Science Exchange and the Center for Open Science, are leading efforts to replicate psychology and cancer studies to pinpoint major sources of irreproducibility.
Although there is no consensus on how to solve the problem, suggestions include improving training for young scientists, describing methods more completely in published papers and making all data and reagents available for repeat experiments.
Dec 18, 2015
Dr. Krishna Kumari Challa
This year's top science stories:
4. Understanding why life got so complicated; why?
Microbes discovered in Arctic mud could be the closest relatives yet found to the single-celled ancestor that swallowed a bacterium and made life so complicated. Biologists have proposed that this swallowing event, perhaps 1.8 billion years ago, led to complex cells with membrane-wrapped organelles, the hallmark of all eukaryotes from amoebas to zebras.
Researchers discovered the new phylum of microbes, dubbed Lokiarchaeota, by screening DNA from sediment . Though no one has identified an actual cell yet, the new phylum appears to mingle genes similar to those in modern eukaryotes and genes from archaea, the sister group to bacteria. Analyses suggest the cells have dynamic structures that could have engulfed bacteria long ago. (Biologists have proposed representing that merger as a ring of life, rather than a tree.) What happened next in the tale is clearer but still a puzzle.
5. New light on Quantum Spookiness; Why?
Some loopholes no longer plague a crucial test for assessing the weirdness of quantum mechanics. Experiments reported in 2015 definitively demonstrate that the quantum world violates locality, the principle that events sufficiently separated in spacetime must be independent.
European researchers this year performed an experiment with electrons on opposite sides of a university campus, nearly 1.3 kilometers apart. In trials lasting 18 days, the team coaxed the electrons into an entangled state 245 times, reliably measuring the electrons’ spins every time. The results showed a clear nonlocal connection.
6. Epigenome effect; Why?
This yea,r Researchers cataloged how chemical modifications fold, compress and unwind the static DNA over time and how those modifications control when genes are on or off. The researchers cataloged epigenetic marks — chemical modifications either of DNA itself or proteins called histones — in more than 100 types of human cells. The epic effort revealed that gene variants associated with Alzheimer’s disease are more active in immune cells in the brain than in nerve cells as researchers had assumed. Another interesting aspect of this research:Tightly packed areas of the genome are more vulnerable to cancer-causing mutations.
Researchers using data from this project and other efforts to view the genome in 3-D have made startling discoveries . For instance, researchers found that a gene called FTO, thought to be a major genetic contributor to obesity, isn’t involved in fat production. Instead, a genetic variant hiding in the gene’s vicinity actually determines what type of fat the body builds . Disorganized DNA may be a cause of aging, researchers also discovered .
Dec 18, 2015
Dr. Krishna Kumari Challa
This year's top science stories:
7. The discovery that Alzheimer's protein behaves like a prion; Why?
Under some conditions, an Alzheimer’s-related protein may have jumped between people, scientists reported this year. If true, that observation, the first of its kind, could recast the way scientists view the disease.
Scientists already had hints that the protein in question, amyloid-beta, behaves like an infectious prion, a misshapen protein that coaxes other proteins to misfold and spread from cell to cell. In a study reported in Nature, Collinge and colleagues found A-beta buildup in four of eight postmortem brains from people who had received growth hormone injections derived from cadavers. Because A-beta buildup is rare in relatively young people — all were between the ages of 36 and 51 — the finding suggests that the buildup might have been seeded by growth hormone contaminated with A-beta.
This result adds to evidence that prions may be behind Alzheimer’s disease as well as other neurodegenerative disorders such as Parkinson’s and Huntington’s. But some scientists caution that it’s too soon to label these disorders as prion diseases.
8. The genetics of cancer; Why?
Personalized genomics has been heralded as the next big weapon in the war on cancer. But researchers analyzing various tissue types this year, looking for mutations linked to the disease, have found that not all genetic alterations should be targeted equally.
Genetic profiles of tumors offer unprecedented opportunities for both cancer diagnostics and for doctors planning treatment. Bowel cancer tumors with mutations in the KRAS gene, for example, respond poorly to the drug cetuximab; the skin cancer drug vemurafenib works only if melanomas have a particular mutation in the BRAF gene.
But such genetic testing can be misleading if it isn’t conducted alongside tests of healthy cells from the same person. A vast analysis comparing the genetic profiles of tumors and normal tissue of more than 800 cancer patients found that nearly two-thirds of mutations in the studied tumors — many of which might be used to guide treatment — also showed up in patients’ healthy tissues . For those patients, the mutations were probably just benign variants unrelated to the cancer. Analyzing healthy tissue can also reveal whether mutations found in tumors are heritable or not, scientists say, which is important for deciding whether a cancer patient’s family should receive genetic counseling.
Complicating matters further is the fact that even mutations that have been linked to cancer will not always manifest as cancer. A study published in May examining eyelid skin discovered numerous cancer-associated mutations in normal, healthy patches of the skin . Detecting these mutations might lead to great anxiety and unnecessary, sometimes invasive treatments.As genetic testing of tumors becomes more widespread, best practices will emerge, as will a better understanding of the disease. Therefore, scientists working in the field are trying to change the way we look at cancer.
Dec 18, 2015
Dr. Krishna Kumari Challa
Here is some good news for science communicators:
Stephen Hawking launches medal for science communication
Renowned British cosmologist Stephen Hawking on Wednesday launched an award for science communication that will bear his name.
The "Stephen Hawking Medal for Science Communication" will be awarded to those who help promote science to the public through media such as cinema, music, writing and art.
"People worldwide display an incredible appetite of scientific information... The public want to know, they want to understand."
The first medals will be awarded next summer in three different categories: the scientific, artistic and film communities.
The winners will be announced at the Starmus Festival, a gathering celebrating art and science in Spain's Canary Islands that will take place from June 27 to July 2 next year.
Dec 18, 2015
Dr. Krishna Kumari Challa
Dec 19, 2015
Dr. Krishna Kumari Challa
Microbial community assembly and metabolic function during mammalian corpse decomposition
http://www.sciencemag.org/content/early/2015/12/09/science.aad2646
You are filled with bacteria, and you are covered in them. And a whole lot of them are just waiting for you to drop dead.
As soon as you die, they’ll swoop in. This week, we learned exactly how microbes chow down on us. A brave and strong-stomached team of scientists spent months watching dead bodies decompose, tracking all the bacteria, fungi, and worms, day by day. Forensic scientists can use this timeline, published in Science, to help determine time—and even place—of death.
http://phenomena.nationalgeographic.com/2015/12/12/youre-surrounded...
Dec 20, 2015
Dr. Krishna Kumari Challa
Why some animals, especially those people consume contain mercury?
Here is the answer...
It is advisable for children and pregnant women not to eat too much fish. Why? Because they might contain harmful mercury!
Mercury pollution, from sources such as gold mining and power generation, ends up in the atmosphere and then the oceans, where it is transformed into methylmercury, which is as toxic as the element. Methylmercury accumulates in ocean creatures, and animals higher up in the food chain, such as tuna, tend to have higher levels of mercury. People who eat enough of those fish can experience health problems; mercury can impair development in children, infants and fetuses.
In 2012, researchers reported that methylmercury could be found in fog water along the central Californian coast. Now researchers are finding that the mercury, picked up from ocean water, is being deposited on land and accumulating in animals, from spiders to mountain lions. Starting with arthropods, wolf spiders, camel crickets and pill bugs all contained mercury. The researchers found mercury in all the arthropods, but the highest levels were in the wolf spiders, the team reported in the April Bulletin of Environmental Contamination and Toxicology. Wolf spiders are carnivorous, and they appeared to be acquiring more mercury through bioaccumulation. Other species, bigger ones, may also be affected.
Preliminary data shows high levels of mercury in deer in central California and in the mountain lions that eat them. A couple of mountain lions had mercury levels high enough that they could be experiencing health problems.
Researchers are still working to trace the path of toxic mercury from ocean waters to fog to land to animals, and on up the food chain.
But this research is a worrying sign that mercury pollution may be a much bigger problem than we realize, and one that can’t be solved by simply limiting the amount of tuna you eat.
- Science News. org
Dec 25, 2015
Dr. Krishna Kumari Challa
HIV antibody infusion safely suppresses virus in infected people
A single infusion of a powerful antibody called VRC01 can suppress the level of HIV in the blood of infected people who are not taking antiretroviral therapy (ART), scientists at the US National Institutes of Health report in a paper published on 23rd Dec, 2015. The researchers also found that giving HIV-infected people VRC01 antibodies by infusing them into a vein or under the skin is safe and well tolerated, and the antibodies remain in the blood for an extended period.
The researchers found that while antibody infusions did not reduce the amount of HIV in blood cells, they reduced plasma viral load more than 10-fold in six of the eight people who were not on ART. In the two people in this group who began the study with the lowest viral loads, the antibody suppressed HIV to extremely low levels for approximately 3 weeks--as long as VRC01 was present at therapeutic concentrations. In the other four people whose HIV levels declined, their viral load fell substantially but did not reach undetectable levels. In the two people not on ART whose viral loads remained steady despite the antibody infusion, it was subsequently found that the predominant HIV strain in their bodies had been resistant to VRC01 at the outset. The antibody also did not appear to have any effect in people taking ART, whose virus was already suppressed.
- Sciencecodex.com
Dec 25, 2015
Dr. Krishna Kumari Challa
https://vimeo.com/33354622#embed
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Dec 29, 2015
Dr. Krishna Kumari Challa
Which hemisphere of the brain does what? Here is the explanation with proof!
--Dec 30, 2015
Dr. Krishna Kumari Challa
Dec 30, 2015
Dr. Krishna Kumari Challa
New medicine to fight drug -resistant Mycobacterium tuberculosis, the bacterium responsible for causing tuberculosis (TB). Scientists from India and the US say they have discovered a group of compounds that can kill Mycobacterium tuberculosis by disabling a major defense mechanism it uses to survive in the human body.
The study, supported by the National Institutes of Health, India’s ministry of science and technology and the Wellcome Trust-Department of Biotechnology alliance was published in ACS Chemical Biology.
These plant based compounds show tremendous promise as lead scaffolds for the development of new, anti-TB treatments. Specifically, these compounds inhibit the function of a critical enzyme responsible for survival of M. tuberculosis .
The new compounds belong to the ellipticine plant alkaloid family, which also is active in targeting cancerous cells. The active compounds have exerted a very high activity against drug-resistant M. tuberculosis strains isolated from patients of Indian origin. The new compounds have shown potent bactericidal activity against active as well as dormant form of drug-susceptible and MDR/XDR strains.
http://pubs.acs.org/doi/10.1021/acschembio.5b00517
Dec 30, 2015
Dr. Krishna Kumari Challa
Bipolar disorder, or manic-depressive illness, causes dramatic mood shifts – often called episodes – in which the person is overly excited, extremely sad or depressed, or a mixed state of both, including irritable or explosive behavior, according to the National Institute of Mental Health, part of the National Institutes of Health.
Causes of bipolar disorder (BP) are thought to be both genetic and environmental, and researchers have long suspected that disruption in normal daily circadian rhythms, including sleep and wake cycles, can precede mood shifts.
Researchers in a recent study found that those with bipolar disorder awoke later and slept longer, on average were awake fewer minutes overall, and were active for shorter periods than those without the disorder. Researchers also found that those with bipolar disorder displayed lower activity levels while awake and had greater variations in sleep and wake cycles. The findings are reported in the journal Proceedings of the National Academy of Sciences.
A team of international scientists led by UT Southwestern Medical Center and UCLA researchers have identified a dozen inherited traits related to sleep, wake, and activity cycles that are associated with severe bipolar disorder. Researchers also were able to tie the traits to specific chromosomes, providing important clues to the genetic nature of the disorder, as well as potential new avenues for prevention and treatment.
The 13 endophenotypes (biological or behavioral markers found more commonly in those with a certain disease than without) are: mean of awake duration, amplitude, Hill acrophase, interdaily stability, interdaily variability, median activity, relative amplitude, mean length of sleep bouts during the sleep period, mean number of sleep bouts during awake period, time of sleep offset, time of sleep onset, mean total minutes scored awake, and WASO (total minutes in awake bouts after sleep onset).
http://www.pnas.org/content/early/2015/12/23/1513525113.abstract
Dec 31, 2015
Dr. Krishna Kumari Challa
Reusable launch vehicle trial in 2016 - ISRO
India’s reusable launch vehicle being developed by the Indian Space Research Organisation (ISRO) is slated for trials in 2016 and will help reduce the cost of access to space in the long run, said ISRO Chairman A.S. Kiran Kumar.
The project was still in the experimental stage and the demonstration vehicle will have a range of 100 km, though eventually it will be like a space shuttle. The ISRO uses multi-stage rockets for satellite launch, but the reusable vehicle will be a single-stage rocket to start with. The single-stage rocket will have a solid propellant stored in casing. For a reusable vehicle, the casings have to be re-used or rebuilt and its evolution will hinge on cost benefits, said the ISRO chairman.
Dec 31, 2015
Dr. Krishna Kumari Challa
How much would you weigh on another star? The timescale of turbulence and vibration at a star's surface, based on its brightness variations, tells you its surface gravity. If stars had solid surfaces on which you could stand, then your weight would change from star to star. Here we show how much a 75-kg adult would tip the bathroom scale in the surface gravities of three stars. The sun is hotter than a sauna, but don't expect to lose weight there. You'd weigh 20 times more than on Earth. A red giant star (the far-future fate of our Sun, with a diameter about 35 times larger) has a much weaker pull at its surface, so you'd be 50 times lighter.
Jan 1, 2016
Dr. Krishna Kumari Challa
103rd version of Indian Science congress was inaugurated by Indian PM, Mr. Narendra Modi in Mysore on 3rd Jan., 2016.
On Sunday, the opening day of the 103rd Indian Science Congress on the verdant campus of Mysore University, top foreign and Indian scientists again highlighted India’s particle physics research initiatives.
After playing a key role in international research initiatives like the Large Hadron Collider project at CERN to find the Higgs Boson, India is participating in several mega initiatives — a global nuclear fusion experiment called International Thermonuclear Experimental Reactor (ITER) in France, a Laser Interferometer Gravitational-wave Observatory (LIGO-India) and a world-class, underground India-based Neutrino Observatory (INO).
“Nearly 10 per cent of the contribution in the ITER project is from India. This will help in leapfrogging India’s nuclear fusion programme,’’ former ISRO chairman K Kasturirangan said Sunday during a talk on mega science projects being taken up by India.
The ITER project, which involves the European Union, the United States, Russia, China, Japan and South Korea apart from India, will create the world’s largest confined plasma physics experiment facility in an effort to move towards full-fledged nuclear fusion plants for power generation. The reactor is scheduled to begin basic experiments by 2020 and will produce 500 MW using nominal energy inputs, Kasturirangan said.
The Rs 1,500-crore observatory for neutrinos (a subatomic particle) is planned near Theni in Tamil Nadu.
LIGO-India is an international collaboration to study gravitational waves, which were incidentally first theorised in Albert Einstein’s Theory of General Relativity. Scientists from the US, UK, Germany and Australia, under the aegis of an Indian Initiative for Gravitational Observations (IndIGO), will help Indian scientists set up and operate a world-class observatory.
Jan 4, 2016
Dr. Krishna Kumari Challa
Reason for frothing lake...
Phosphates in detergents is what causes frothing Bellandur lake in Bangalore.
Based on a report by researchers from Indian Institute of Science (IISc.), Union Environment Minister Prakash Javadekar said on Thursday he would consider restrictions on detergents which were considered the primary reason for the froth that has engulfed the nearly 700-acre lake.
“I will take it up with the department concerned, to check if an alternative that is environmentally friendly and cost-effective to phosphates can be used. If we can ban diclofenac (a painkiller for cattle which was found to be the reason for the mass deaths of endangered vultures), then we can surely consult and think of a better alternative,” he said at a seminar on climate change here.
The Minister was briefed about the problems of Bellandur lake, where froth started to rise alarmingly in April 2015, and within a month, a portion of froth was even seen catching fire.
A recent report by researcher T.V. Ramachandra on the pollution in the lake, submitted to the Minister, conclusively shows that the froth appeared because of higher concentration of phosphates in the lake.
Phosphates form a major component in household detergents, and make their way to the lake through the estimated 500 million litres of sewage that flows into Bellandur and Vathur lakes. Phosphates do not disintegrate, and continue to remain in the water, which ends up being used for agriculture further downstream of the lake.
The researcher had previously said that more than 70 per cent reduction in phosphates was needed to reduce eutrophication (excessive nutrients in the lake that cause dense growth of plants, including water hyacinth) in the lake. This sort of reduction has been seen in lakes of developed countries where stringent measures on phosphates were imposed to preserve waterbodies.
On May 16, 2015, Pockets of froth on the lake caught fire, which is believed to have been caused by built-up methane in the bubbles.
High phosphate regions are when the limit reaches 4.22 to 5.76 parts per million (for drinking water, less than 0.1 ppm prescribed by the WHO)
Enhanced biological oxygen demand is when 119 to 140 parts per million (should be 30 ppm or less)
Decreased dissolved oxygen is 0 to 1.06 parts per million
Excessive phosphate encourages wild growth of algae and aquatic plants which sucks up oxygen from the lake and chokes inlets. This in turn adversely affects flora and fauna of the lake.
Jan 4, 2016
Dr. Krishna Kumari Challa
The periodic table has been given four new elements, changing one of science’s most fundamental pieces of knowledge.
Elements 113, 115, 117 and 118 will now be added to the table’s seventh row and make it complete, after they were verified by the International Union of Pure and Applied Chemistry on 30 December,2015. But they are yet to receive their final names or symbols.
The new elements were discovered by team from Japan, Russia and the USA, who will all get to name their own new elements.
Read more
All of the four new admissions are man-made. The super-heavy elements are created by shoving lighter nuclei into each other and are found in the radioactive decay — which only exists for a tiny fraction of a second before they decay into other elements.
Jan 5, 2016
Dr. Krishna Kumari Challa
Graphene shows promise to efficiently filter nuclear waste
Membranes made from graphene can act as a sieve, separating protons from heavier nuclei of hydrogen isotope deuterium
graphene can be used to clean up nuclear waste by filtering different isotopes of hydrogen, a new study has found.
Researchers led by Andre Geim from University of Manchester in UK demonstrated that using membranes made from graphene can act as a sieve, separating protons — nuclei of hydrogen — from heavier nuclei of hydrogen isotope deuterium.
The process could mean producing heavy water for nuclear power plants could be ten times less energy intensive, simpler and cheaper using graphene.
One of the hydrogen isotopes, deuterium, is widely used in analytical and chemical tracing technologies and, also, as heavy water required in thousands of tonnes for operation of nuclear power stations.
The heaviest isotope, tritium, is radioactive and needs to be safely removed as a byproduct of electricity generation at nuclear fission plants. Future nuclear technology is based on fusion of the two heavy isotopes.
The researchers found that deuterons were not only effectively sieved out by their one atom thick membranes, but were sieved with a high separation efficiency. The discovery makes monolayers of graphene and boron nitride attractive as separation membranes to enrich mixtures of deuterium and tritium.
Furthermore, the researchers showed that the separation is fully scalable. Using chemical-vapour-deposited (CVD) graphene, they built centimetre-sized devices to effectively pump out hydrogen from a mixture of deuterium and hydrogen.
The study was published in the journal Science.
Jan 9, 2016
Dr. Krishna Kumari Challa
Jan 10, 2016
Dr. Krishna Kumari Challa
A new half-solid, half-liquid material can heal itself ...
A new half-solid, half-liquid adaptive material created by scientists in the US displays a number of amazing properties, including the ability to self-heal – stitching itself back together once divided – and self-stiffen back into its original shape after being compressed.
The material, called SAC – which stands for self-adaptive composite – is composed of a mass of sticky, micron-scale rubber balls that cling together to create a solid matrix. The composite is capable of healing itself repeatedly when cracked, and behaves kind of like a sponge, regaining its original form after being disturbed.
Jan 14, 2016
Dr. Krishna Kumari Challa
http://www.currentscience.ac.in/Volumes/109/12/2195.pdf
Jan 15, 2016
Dr. Krishna Kumari Challa
Astronomers have discovered the brightest star explosion ever, a super supernova that easily outshines our entire Milky Way. An international team revealed “the most powerful supernova observed in human history” Thursday in the latest Science journal. The astronomers used a network of telescopes around the world to spot the record-breaking supernova last year.
Jan 16, 2016
Dr. Krishna Kumari Challa
How can plants grow in space?
Yes, they have a problem in space...Zero Gravity!
The complication that needs to be overcome is that plants make use of gravity when planted to orient themselves (as they can't rely on being planted the right way up), so that their roots go down and their sprouts go up. Without gravity, they will tend to just stay at around the same depth and not sprout. One astronaut reported that this was simple enough to fix, however, just by plucking the ends out of the soil, pulling them to the surface, when they first sprout. From this point, the plant can orient itself using light and will continue to grow. Roots don't suffer as much, as they just grow away from the seed and avoid light (the surface), so develop relatively normally.
After this, growth is mostly normal. The resulting plants can look a little unusual because they don't have the usual drooping from gravity, so will tend to be more upright.
Crew members aboard the International Space Station have been growing plants and vegetables for years in their "space garden." A space station study is helping investigators develop procedures and methods that allow astronauts to grow and safely eat space-grown vegetables.
Surprises in microgravity research are not unusual, though, and it turned out that overwatered traditional module sprouted and developed leaves about twice as fast.
The second surprising result was discovered when the root modules were unpacked on the ground. The new fertilizer being tested had a slower and more even release rate, which had helped lower the plants' accumulation of salts during ground studies. Investigators expected to see higher salt accumulation in the space modules, but the opposite occurred.
The current theory is that the extra water and larger plant uptake of fertilizer caused the root modules to remove nutrients faster and release fertilizer faster, thus preventing the salt accumulations that were observed in the slower-growing ground studies.
The space station's ability to provide on-the-spot adjustments to experiment conditions or opportunities to quickly repeat microgravity experiments with new conditions are a big plus for researchers.
Read more here:
Growing Plants and Vegetables in a Space Garden
Jan 16, 2016
Dr. Krishna Kumari Challa
Q:How can we receive digital imagery of Pluto so quickly from across the solar system?
Answer: Pluto is about 4.9 billion kilometers away from earth. The digital imagery is transmitted via wireless communication, which is based on electromagnetic radiation which travels with light speed, e.g. about 300.000 kilometers per second in the vacuum of space. Which means signals need about 4 1/2 hours to earth. It takes additional time to actually transmit all the data, but probably not too much. Five hours all in all are enough.
Jan 20, 2016
Dr. Krishna Kumari Challa
More than 90 percent of the heat trapped by greenhouse gas pollution since the 1970s has wound up in the oceans, and research published Monday revealed that a little more than a third of that seafaring heat has worked its way down to depths greater than 2,300 feet (700 meters).
Plunged to ocean depths by winds and currents, that trapped heat has eluded surface temperature measurements, fueling claims of a “hiatus” or “pause” in global warming from 1998 to 2013. But by expanding cool water, the deep-sea heat’s impacts have been indirectly visible in coastal regions by pushing up sea levels, contributing to worsening high-tide flooding.
The research, published in Nature Climate Change, was led by Lawrence Livermore National Laboratory.
http://www.nature.com/nclimate/journal/vaop/ncurrent/full/nclimate2...
Jan 20, 2016
Dr. Krishna Kumari Challa
Adding pollinators could boost small-farm yields
Analysis shows bees, bugs could significantly increase crop production in poor-performing farms.
Coaxing more bees, beetles and other pollinators to buzz around small fields could on average boost crop yields enough to close the gap between the worst and the best of these farms by almost a quarter, says agroecologist Lucas Alejandro Garibaldi of the National University of Río Negro and Argentina’s CONICET research network.
To see whether improving pollination could make a noticeable difference, Garibaldi and an international network of researchers carefully used the same sampling protocols to observe 344 fields on large and small farms in Africa, Asia and South America over the course of five years. Looking at 33 crops that need pollinators — raspberries, apples, coffee and so on — the researchers monitored pollinator visits and diversity as well as the ultimate yields.
The low-yielding farms on average produced only 47 percent of the yield that the best did, a notable gap. On the small operations, the sheer density of pollinators visiting crop flowers made a bigger difference in the amount of food produced, the researchers found. On larger farms, pollinator diversity mattered more: Those farms with a greater variety of pollinators produced more food.
Analyzing the way yields responded to the number of pollinators shows that improving pollination could help close the yield gap, Garibaldi and his colleagues say in the Jan. 22 Science.
Jan 22, 2016
Dr. Krishna Kumari Challa
When you see a bad moon rising, expect an ever-so-slightly wetter day. The lunar gravitational pull imperceptibly boosts rainfall when the moon is on the horizon and somewhat reduces rainfall when the moon is overhead or on the opposite side of the Earth, a new analysis of global rainfall concludes.
The cause is the atmospheric equivalent of ocean tides, researchers propose in a paper to be published in Geophysical Research Letters. Air gathers on Earth’s moon-facing side and on the opposite end of the globe. Scientists noticed that this pileup increases atmospheric pressure and predicted that atmospheric tides could alter precipitation rates as well. Scouring 15 years of global precipitation data, the researchers have discovered that the effect is present, but tiny: an approximately one micrometer per hour change in rainfall rate.
The moon’s gravitational pull, which is responsible for ocean tides, also creates atmospheric tides. As more air gathers during atmospheric high tide, atmospheric pressure increases. Satellites now offer global coverage of where and when rain falls.
The data revealed that during atmospheric high tide, rising air pressure slightly increases air temperature. That temperature boost allows the air to hold more water vapor, lowering the relative humidity and making rain less likely. During low tide, pressures drop slightly, cooling the air, raising the relative humidity and making rain more likely. This effect amounts to about a hundredth that of the typical background weather variability.
Understanding the lunar influence on rainfall won’t change how we predict the weather. The effect is so small that it quickly disappears into the background noise with time.
- Science News.Org
Jan 22, 2016
Dr. Krishna Kumari Challa
How planet X was found...
Researchers inferred Planet X's presence from the peculiar clustering of six previously known objects that orbit beyond Neptune.
They say there's only a 0.007% chance, or about one in 15,000, that the clustering could be a coincidence.
Instead, they say, a planet with the mass of 10 Earths has shepherded the six objects into their strange elliptical orbits, tilted out of the plane of the solar system.
Jan 26, 2016
Dr. Krishna Kumari Challa
The editors of the leading medical journals around the world made a proposal recently that could change medical science forever. They said that researchers would have to publicly share the data gathered in their clinical studies as a condition of publishing the results in the journals. This idea is now out for public comment.
As it stands now, medical scientists can publish their findings without ever making available the data upon which their conclusions were based.
Only some of the top journals, such as The BMJ, have tried to make data sharing a condition of publication. But authors who didn't want to comply could just go elsewhere.
Think about it. The scientists who generate the data, with the participation of the people being studied and often with public funding, control it and most often don't share. By holding the data tight, researchers who ran a study are the only ones who can conduct additional analysis and studies.
If the proposed change is adopted it would make sharing more compelling. Inaccessible data is a problem rife throughout medical science. Industry traditionally held its data close — but so did academics.
These researchers have felt that they deserved the right to future papers for all their hard work gathering the original data. And maybe they didn't want others examining their work.
But this practice shields data from scrutiny. It forgoes an opportunity to crowdsource knowledge from scientists who weren't associated with the original study. It also violates the sensible practice of showing your work, not just the presumed answer.
The editors who made the proposal sought to be sensitive to the rights of researchers, funders and participants. But their intent is clear: It's time to share.
http://www.npr.org/sections/health-shots/2016/01/26/464010931/journ...
Jan 27, 2016
Dr. Krishna Kumari Challa
Jan 27, 2016
Dr. Krishna Kumari Challa
Tenacious proteins similar to those implicated in Alzheimer’s disease could help purify polluted water.
A newly designed membrane uses thin amyloid protein fibers to pull heavy metals and radioactive wastes out of water. The membranes can capture more than their own weight in some contaminants, scientists in Switzerland report January 25 in Nature Nanotechnology.
Specifically, the team converted milk proteins into fibers of durable amyloid protein. Other amyloids are infamous for building up in the brains of Alzheimer’s patients, but the team put their amyloids’ sticky tendrils to different use.
When paired with strong, porous carbon in a membrane, the lab-made amyloids successfully filtered over 99 percent of toxic materials out of solutions that mimicked severely polluted waters, the scientists report. The amyloids trapped particles of lead and mercury at a molecular site that is involved in turning the original milk protein into its pasty form. Radioactive waste particles also got tangled in the membranes. And the membranes snagged gold contaminants, which the team found could later be recovered and purified. A membrane with less than 6 milligrams of amyloids could trap 100 milligrams of gold, the scientists report.
The membranes could be developed for small- or large-scale water purification units, says study coauthor Raffaele Mezzenga, a physicist at ETH Zurich. Mezzenga estimates the technology would cost roughly one dollar per every thousand liters of water filtered. And a membrane can recover hundreds of times its own value in precious metals, Mezzenga says. The membrane design is simple and flexible, and could be adjusted to optimize cleanup or metal recovery, he says.
http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2015.3...
Jan 27, 2016
Dr. Krishna Kumari Challa
A new global analysis of seafood found that fish populations throughout the world's oceans are contaminated with industrial and agricultural pollutants, collectively known as persistent organic pollutants (POPs). The study from researchers at Scripps Institution of Oceanography at UC San Diego also uncovered some good news?concentrations of these pollutants have been consistently dropping over the last 30 years. The findings, reported in the Jan. 28, 2016 issue of the journal PeerJ, were based on an analysis by Scripps researchers Lindsay Bonito, Amro Hamdoun, and Stuart Sandin of hundreds of peer-reviewed articles from 1969-2012. The pollutants studied included older 'legacy' chemicals, such as DDT and mercury, as well as newer industrial chemicals, such as flame retardants and coolants.
Although POPs were found in fish in all of the world's oceans, the researchers say that concentrations in the consumable meat of marine fish are highly variable, where one region or group of fish may find concentrations of POPs that vary by 1,000-fold. The analysis revealed that average concentrations of each class of POP were significantly higher in the 1980s than is found today, with a drop in concentration of 15-30 percent per decade.
"This means that the typical fish that you consume today can have approximately 50 percent of the concentration of most POPs when compared to the same fish eaten by your parents at your age," said Bonito, the lead author of the study. "But there still remains a chance of getting a fillet as contaminated as what your parents ate.
The authors caution that although pollutant concentrations in marine fish are steadily declining, they still remain quite high, and that understanding the cumulative effects of numerous exposures to pollutants in seafood is necessary to determine the specific risk to consumers.
Source: University of California - San Diego
and Science news
Jan 29, 2016
Dr. Krishna Kumari Challa
Electrons do not orbit around an atomic nucleus like planets around a star. This outdated model of the atom (called the Bohr-Rutherford model) is still taught in schools, but only as an introduction to modern ideas about the atom.
Max Born showed us that electrons do not have a definite position, but instead exist as probability wave functions that describe how likely it is that the electron would be at a particular point in its atomic orbit. That is to say, the electron exists in a superposition of all possible locations around the atom. Werner Heisenberg discovered that it isn't until an electron is observed (detected by an instrument) that its wave function collapses and it takes on a discrete location.
So, really, electrons do not orbit around a nucleus; they exist in all possible locations around that nucleus simultaneously. Quantum mechanics!
Electrons don't orbit around atomic nucleuses like planets around a star. But that doesn't mean that they aren't moving.
The probability density for an electron is symmetric around the nucleus, so the average velocity would cancel out to zero. So let's calculate a typical speed from the square-root of the average velocity squared instead. (This is the referred to as root-mean-squared or r.m.s. for short.)
It's actually pretty easy to figure out the r.m.s. velocity for a typical electron from a few physics facts.
First, we need to the know the binding energy of the electron to the nucleus. We might as well assume it's in hydrogen, the simplest atom, so it has total binding energy of E = -13.6 eV (electron-volts):
Next, we need to know what part of the energy is kinetic (moving) instead of potential (due to the electric force holding the atom together). For closed orbits (electrons or planets), there is very handy relationship known as the Virial Theorem [1]. The Virial Theorem tells us that for particles experiencing an attractive 1/r21/r2 force like that between opposite charges, the average kinetic energy is equal to the negative of the total energy:
⟨T⟩=−E⟨T⟩=−E.
To calculate the r.m.s. velocity, we just need the non-relativistic [2] formula relating kinetic energy T and velocity v:
T=12mv2T=12mv2,
where m is the mass of the object.
Solving the above equations, we find:
vrms=−2Em−−−−√.vrms=−2Em.
Plugging in the binding energy and mass of an electron, we see that our hypothetical electron is moving at 2.2*10^6 m/s [3] or just shy of 5 million mph. Fast, but still about a factor of 100 times slower than the limit, the speed of light.
Jan 30, 2016
Dr. Krishna Kumari Challa
Till now we are under the impression that earthworms are highly beneficial to plants. But listen to this: Earthworms not always beneficial, may threaten plant diversity!
A new study suggests that an abundance of earthworms in soils could lead to reductions in the number of trees and and other plant species.
Contrary to the popular belief that these creatures and beneficial to the natural ecosystem, the scarcity of these invertebrates can be a threat to certain plant species, causing adverse effects on the ecosystem.
Researchers from Canada's Université Laval and Université de Sherbrooke visited sugar maple forests in Quebec province where they found half of which were populated by earthworms.
Their analysis revealed a correlation between the number of earthworms and the abundance and diversity of certain understory species as they found that new shoots of red maple, striped maple, American beech, and two fern species became rarer as populations of these invertebrates increased.
"The most likely explanation is that the earthworms consume organic matter in forest litter," said Line Lapointe, a professor at Université Laval's faculty of science and engineering and the study's lead author.
"This results in soils that can't hold as much moisture, and that in turn interferes with seed germination and the ability of some species' plantlets to survive," she added.
Earthworms have started to change plant composition in sugar maple forests, according to the researchers.
Researchers suggest that earthworms used for bait should never be released in the forest, instead they be thrown into the lake to avoid overpopulation in the ecosystem.
The study has been published in the journal Forest Ecology and Management.
Jan 31, 2016
Dr. Krishna Kumari Challa
New evidence emerges for 'transmissible Alzheimer's' theory:
Autopsies reveal plaques in the brains of people who died after receiving grafts from cadavers.
For the second time in four months, researchers have reported autopsy results that suggest Alzheimer’s disease might occasionally be transmitted to people during certain medical treatments — although scientists say that neither set of findings is conclusive.
The latest autopsies, described in the Swiss Medical Weekly1 on 26 January, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt–Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater — the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.
But in addition to the damage caused by the prions, five of the brains displayed some of the pathological signs that are associated with Alzheimer’s disease, researchers from Switzerland and Austria report. Plaques formed from amyloid-β protein were discovered in the grey matter and blood vessels. The individuals, aged between 28 and 63, were unusually young to have developed such plaques. A set of 21 controls, who had not had surgical grafts of dura mater but died of sporadic CJD at similar ages, did not have this amyloid signature.
According to the authors, it is possible that the transplanted dura mater was contaminated with small ‘seeds’ of amyloid-β protein — which some scientists think could be a trigger for Alzheimer’s — along with the prion protein that gave the recipients CJD.
http://www.smw.ch/content/smw-2016-14287/
http://www.nature.com/news/autopsies-reveal-signs-of-alzheimer-s-in...
Feb 2, 2016
Dr. Krishna Kumari Challa
UK scientists just got approval to edit human embryos
Scientists in Britain just got approval to conduct research that involves editing the genetic material of healthy human embryos.
This is a big deal: The UK's Human Fertilisation and Embryology Authority is the first government agency in the world to endorse research that involves altering the human genome for research — a move that could signal broader acceptance for a promising (but controversial) new area of science.
The research team, led by Dr. Kathy Niakan at the UK's Francis Crick Institute, is trying to better understand which genes allow a healthy human embryo to develop. Niakan’s team will use a promising new technique, known as CRISPR/Cas9, to edit genes that are active following conception. They'll then stop the experiments at day seven and destroy the embryos (so that they can't be used to start a pregnancy).
The hope is that this gene hacking could help researchers better understand what causes miscarriages and infertility — and perhaps one day lead to better treatments for infertility.
Feb 2, 2016
Dr. Krishna Kumari Challa
Small ponds produce an outsized share of greenhouse gases
Tiny ponds play a disproportionately large role in global greenhouse gas emissions from inland waters, according to a new study by Yale's School of Forestry & Environmental Studies.
The reason has to do with the physical makeup of very small ponds and the way they cycle carbon. Small ponds have a high perimeter-to-surface-area ratio, for example, and accumulate a higher load of terrestrial carbon -- so-called "leaf litter," sediment particles and other material. Small ponds also tend to be shallow, which means their terrestrial carbon loads are highly concentrated compared to larger lakes. Lastly, gases produced at the bottom of these ponds are able to reach the top more often than what occurs in larger lakes, due to greater water mixing and shallower waters. Because of this, CO2 and CH4 generated in sediments affects the entire pond.
That makes small ponds an important player in the carbon cycle.
The carbon cycling that happens in freshwater systems needs to be accounted for in estimates of terrestrial production. These numbers are important to quantifying the global carbon cycle and making predictions about future stocks and flows of carbon.
Although ponds less than a quarter of an acre in size make up only 8.6% of the surface area of the world's lakes and ponds, they account for 15.1% of carbon dioxide (CO2) emissions and 40.6% of diffusive methane (CH4) emissions. The findings appear in the Feb. 1 online edition of the journal Nature Geoscience.
Feb 2, 2016
Dr. Krishna Kumari Challa
Chromosomes must be accurately segregated during the production of sex cells to ensure that the next generation inherits an intact copy of the genome. However, this process is particularly error-prone in women and gets worse as they get older. Errors in chromosome segregation produce egg cells with the wrong number of chromosomes, which can lead to infertility and Down syndrome .
New eggs develop from immature egg cells (or oocytes) via meiosis: this process involves the original cell’s DNA being replicated once before it divides twice to produce four new cells, each with half the original number of chromosomes. Most errors in the number of chromosomes in human eggs come from mistakes made when the oocyte divides for the first time in a process commonly called meiosis I. Multiple factors can contribute to these errors, but it is not clear which are most significant in human oocytes.
Human oocytes start with 23 pairs of homologous chromosomes, which are split during the anaphase stage of meiosis I so that the egg contains one from each pair. There are two main requirements that must be met during meiosis I. First, each pair of homologous chromosomes must be physically connected to form a “bivalent”. Second, the two sister kinetochores on each chromosome must be functionally fused together so that both sisters connect to the same spindle pole. These two requirements are both compromised in human oocytes. This provides a plausible mechanism to explain the errors often seen in meiosis I in women.
-elifesciences.org
http://elifesciences.org/content/5/e13788?utm_source=content_alert&...
Feb 3, 2016
Dr. Krishna Kumari Challa
Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
Lung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). Now scientists say association between textile dust exposure and the risk of RA in the Malaysian population is real whose correctness has been established with a focus on women who rarely smoke.
Results of the study: Occupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).
Conclusions of the study: This is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA.
http://ard.bmj.com/content/early/2015/11/08/annrheumdis-2015-208278...
Feb 3, 2016
Dr. Krishna Kumari Challa
Ocean acidification and warming could affect the culturing of pearls
Pearl aquaculture is big business, particularly in Asia and Australia. But much of it takes place in oceans, which are susceptible to the increasing amounts of carbon dioxide human activity releases into the atmosphere. CO2 from the air gets absorbed by the oceans, which become more acidic as a result. Research has found that pearl oysters produce weaker shells under these conditions, and this could hurt their chances of survival. But in addition to acidity, rising water temperature could also play a role in oyster health.
- Environmental Science & Technology
http://phys.org/news/2016-01-ocean-acidification-affect-culturing-p...
Feb 3, 2016
Dr. Krishna Kumari Challa
Model of Sun's magnetic field:
Feb 4, 2016
Dr. Krishna Kumari Challa
Mothers who are obese during pregnancy have almost twice the odds of having a child with autism as women who weigh less, a U.S. study suggests.
When women are both obese and have diabetes, the autism risk for their child is at least quadrupled, researchers reported online January 29 in Pediatrics.
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Feb 6, 2016