2020 Heroes of Chemistry

The Science Communication Crisis

Seeing dark matter in a new light

A small team of astronomers have found a new way to 'see' the elusive dark matter haloes that surround galaxies, with a new technique 10 times more precise than the previous-best method.

Scientists currently estimate that up to 85% of the mass in the universe is effectively invisible. This "dark matter" cannot be observed directly, because it does not interact with light in the same way as the ordinary matter that makes up stars, planets, and life on Earth.

So how do we measure what cannot be seen? The key is to measure the effect of gravity that the dark matter produces. It's like looking at a flag to try to know how much wind there is. You cannot see the wind, but the flag's motion tells you how strongly the wind is blowing.

The new research focuses on an effect called weak gravitational lensing, which is a feature of Einstein's general theory of relativity. The dark matter will very slightly distort the image of anything behind it.

Weak gravitational lensing is already one of the most successful ways to map the dark matter content of the Universe. Now, the team has used the ANU 2.3m Telescope in Australia to map how gravitationally lensed galaxies are rotating. Because we know how stars and gas are supposed to move inside galaxies, we know roughly what that galaxy should look like. By measuring how distorted the real galaxy images are, then we can figure out how much dark matter it would take to explain what we see. The new research shows how this velocity information enables a much more precise measurement of the lensing effect than is possible using shape alone.

Pol Gurri et al. The first shear measurements from precision weak lensing, Monthly Notices of the Royal Astronomical Society (2020). DOI: 10.1093/mnras/staa2893

https://phys.org/news/2020-11-dark.html?utm_source=nwletter&utm...

Gold-catalyzed reaction releases an active drug to kill cancer cells

Drugs that are activated inside the body with catalytic quantities of gold could offer a new option for treating cancer and other diseases.

Using metals to convert masked "prodrugs" into their active forms inside the body is an emerging area of biomedical research. These drug-release reactions are designed to be triggered by metals that are not naturally present in the body, providing a new way to trigger drug release that promises to increase the efficacy and reduce the side effects of a therapy.

Kenward Vong et al. Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization, Chemical Science (2020). DOI: 10.1039/d0sc04329j

https://phys.org/news/2020-11-gold-catalyzed-reaction-drug-cancer-c...

**Has the hidden matter of the universe been discovered?

Astrophysicists consider that around 40% of the ordinary matter that makes up stars, planets and galaxies remains undetected, concealed in the form of a hot gas in the complex cosmic web. Today, scientists at the Institut d'Astrophysique Spatiale (CNRS/Université Paris-Saclay) may have detected, for the first time, this hidden matter through an innovative statistical analysis of 20-year-old data.

 H. T Tanimura et al. First detection of stacked X-ray emission from cosmic web filaments, Astronomy & Astrophysics (2020). DOI: 10.1051/0004-6361/202038521

https://phys.org/news/2020-11-hidden-universe.html?utm_source=nwlet...

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**Coronavirus testing finally gathers speed

**SARS-CoV-2 uses 'genome origami' to infect and replicate inside host cells

Scientists at the University of Cambridge, in collaboration with Justus-Liebig University, Germany, have uncovered how the genome of SARS-CoV-2—the coronavirus that causes COVID-19—uses genome origami to infect and replicate successfully inside host cells. This could inform the development of effective drugs that target specific parts of the virus genome, in the fight against COVID-19.

Most current work to find drugs and vaccines for COVID-19 is focused on targeting the proteins of the virus. Because the shape of the RNA molecule is critical to its function, targeting the RNA directly with drugs to disrupt its structure would block the lifecycle and stop the virus replicating.

the team uncovered the entire structure of the SARS-CoV-2 genome inside the host cell, revealing a network of RNA-RNA interactions spanning very long sections of the genome. Different functional parts along the genome need to work together despite the great distance between them, and the new structural data shows how this is accomplished to enable the coronavirus life cycle and cause disease.

"The RNA genome of coronaviruses is about three times bigger than an average viral RNA genome—it's huge

In all cells the genome holds the code for the production of specific proteins, which are made when a molecular machine called a ribosome runs along the RNA reading the code until a 'stop sign' tells it to terminate. In coronaviruses, there is a special spot where the ribosome only stops 50% of the times in front of the stop sign. In the other 50% of cases, a unique RNA shape makes the ribosome jump over the stop sign and produce additional viral proteins. By mapping this RNA structure and the long-range interactions involved, the new research uncovers the strategies by which coronaviruses produce their proteins to manipulate our cells.

The genome of most human viruses is made of RNA rather than DNA. Ziv developed methods to investigate such long-range interactions across viral RNA genomes inside the host cells, in work to understand the Zika virus genome. This has proved a valuable methodological basis for understanding SARS-CoV-2.

 Omer Ziv et al, The short- and long-range RNA-RNA Interactome of SARS-CoV-2, Molecular Cell (2020). DOI: 10.1016/j.molcel.2020.11.004

https://phys.org/news/2020-11-sars-cov-genome-origami-infect-replic...

A potential new treatment for premature aging diseases keeps stem cells fresh longer

The drug helps keep stem cells telomeres long, preventing them from aging too quickly.

The ends of our DNA, called telomeres, get shorter as we age. Our cells lose a bit of telomere every time they divide. This shortening is a normal and needed process that serves a protective function against cancer. This is because the older our cells get, the more likely they are to have accumulated damage or mutations that make them function incorrectly. Telomere shortening helps to take old cells that are reaching their “best before date” off the shelf before they can cause trouble.

But this can backfire: cells can shorten their telomeres too quickly, age rapidly, and die. This is what causes a subset of genetic premature aging diseases, including idiopathic pulmonary fibrosis, forms of aplastic anemia, and a rare disease called dyskeratosis congenita. Unfortunately, there are currently no available drug-based therapies for treating telomere-driven premature aging diseases.

Now, a candidate drug has found a new potential purpose in treating premature aging disease. 

This drug, called RG7834, was originally identified as an inhibitor of hepatitis B virus (HBV). While it has been found to be well-tolerated in short-term administration to living organisms (like rodents and primates), this drug does not cure HBV, and is not yet publicly available. Interestingly, the host cell proteins affected by RG7834 are two enzymes that modify many different RNAs. These enzymes can cause degradation of host cell RNA — so RG7834 keeps RNA around that the cell otherwise might get rid of.

https://massivesci.com/articles/telomere-telomerase-rna-drug-premat...

DNA might replace barcodes to tag art, voter ballots: study

Easy-to-remove barcodes and QR codes used to tag everything from T-shirts to car engines may soon be replaced by a tagging system based on DNA and invisible to the naked eye, according to scientists.

The DNA-based system could help anti-forgery efforts, according to researchers who said thieves struggle to find or tamper with a transparent splash of DNA on valuable or vulnerable items, such as election ballots, works of art, or secret documents.

In an article published in Nature Communications, researchers said that the molecular tagging system, called Porcupine, is -- unlike most alternatives -- cost-effective.

Using DNA for tagging objects has been out of reach in the past because it is expensive and time consuming to write and read, and requires expensive lab equipment.

Porcupine gets around this by prefabricating fragments of DNA that users can mix together arbitrarily to create new tags, the researchers said.

Instead of radio waves or printed lines, the Porcupine tagging scheme relies on a set of distinct DNA strands called molecular bits, or 'molbits' for short.

To encode an ID, scientists pair each digital bit with a molbit.

If the digital bit is 1, they add its molbit to the tag, and if it's 0 they leave it out. Then they can dry it until it's ready to be decoded later. Once the item has been tagged, it can then be shipped or stored.

When someone wants to read the tag, water is added to rehydrate the molecular tag, which is read by a nanopore sequencer -- a DNA-reading device smaller than an Iphone.

The name Porcupine comes from a play on words (PORE-cupine, as in nanopore) and the idea that porcupines can 'tag' objects, and critters that dare to get too close.

Unlike existing systems to tag objects, DNA tags are undetectable by sight or touch. Practically speaking, this means they are difficult to tamper with.

1. Kathryn Doroschak, Karen Zhang, Melissa Queen, Aishwarya Mandyam, Karin Strauss, Luis Ceze, Jeff Nivala. Rapid and robust assembly and decoding of molecular tags with DNA-based nanopore signatures. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-19151-8

https://researchnews.cc/news/3442/DNA-might-replace-barcodes-to-tag...

A month delay to cancer care might raise death risk: study

Delaying cancer treatment by just a month can put patients at a sharply greater risk of dying, according to research published Wednesday, the latest to sound the alarm over the coronavirus pandemic's impact on other health conditions. Treatment delays happen in normal times, but the spread of Covid-19 has caused unprecedented disruption to healthcare services. In a new study published in the BMJ medical journal, researchers in the UK and Canada found that delays in treatment -- whether for surgery, radiotherapy, or other treatments such as chemotherapy -- for seven types of cancers had a significant impact on patient mortality. There has never been a systematic attempt to look at all the evidence on what delays in different types of treatment mean for cancer patient outcomes.

https://www.bmj.com/content/371/bmj.m4087

The COVID-19 Clinical Neuroscience Study (COVID-CNS)

Scientists Just Successfully Regenerated Mouse Optic Nerve Cells in The Lab

Scientists have found a new way to regenerate damaged optic nerve cells taken from mice and grown in a dish. This exciting development could lead to potential eye disease treatments in the future.

Damage to full-grown nerve cells causes irreversible and life-altering consequences, because once nerve fibres mature, they lose their ability to regenerate after injury or disease. The new experiments show how activating part of a nerve cell's regenerative machinery, a protein known as protrudin, could stimulate nerves in the eye to regrow after injury. 

With more research, the achievement is a step towards future treatments for glaucoma, a group of eye diseases which cause vision loss by damaging the optic nerve (that links the eye to the brain).

https://www.nature.com/articles/s41467-020-19436-y

https://www.sciencealert.com/scientists-succeed-in-regenerating-opt...

First Case Study of Its Kind Documents Girl With Mirror Movement And Rare Disorder

If you sit down at a piano, hitting different notes with each hand would be the first step to mastering the instrument. But what if both hands are intent on doing the same thing? That's the experience of people with a rare condition known as mirror movement, and doctors have now documented a unique case.

Several years ago, researchers in India identified a case of this extremely rare condition in a 13-year-old girl who also has a diagnosis of the chromosomal disorder Turner syndrome.  

Finding the two conditions together is a first for the medical community, raising questions of how – or even whether – the two might potentially be connected.

Most tiny humans take a while to become dextrous, but by age 10 the communication between the two halves of our brain allows us to pinch, poke, wave and wiggle the fingers on each hand independently of one another.

For about one in every million children, this development is incomplete, meaning one hand's actions are echoed simultaneously by the other. Make a victory sign with your left hand, and your right will be forced to approximate a similar shape.

The fundamental cause of such copy-cat movement is still largely a matter of speculation, though there's reason to suspect key nerves in the brain are 'cross-talking' as a result of the formation of false synapses between neurons.

In about a third of all cases mutations in a couple of genes appear to be responsible, impairing development of the nervous system in such a way that instructions from either side of the brain are accidentally transmitted to both sides of the body.

individuals who also have cerebral palsy will display degrees of mirror movements. Parkinson's disease is another condition that can come with this form of so-called synkinesia, especially if it affects more one side of the brain than the other.

Having breaks or an absence of connection between the hemispheres – a bridge of neurons called the corpus callosum – can also coincide with the behaviour. It's in many of these cases that a genetic link has been uncovered.

Kallmann syndrome is a condition caused by lack of certain hormones, giving rise to characteristics such as a lack of smell and delayed puberty. And, sometimes, mirror movements.

Turner syndrome is also a condition that impacts on a body's ability to coordinate hormonal responses.

Before this case, nobody had recorded a person who had the chromosomal abnormality and would experience mirror movements as well.

https://casereports.bmj.com/content/13/11/e238482

https://www.sciencealert.com/adolescent-girl-diagnosed-with-mirror-...

Heavy Metal Pollution Is Weakening Scallop Shells And Threatening T...

Shellfish such as scallops, mussels and oysters – bivalve molluscs – readily take up tiny specs of metals into their tissues and shells. In sufficient concentrations this can harm their growth and survival chances, and even threaten the health of any human who eats their contaminated meat. Such shellfish provide one-quarter of the world’s seafood, so the impact of pollution from the “heavy metals” such as lead, zinc and copper, is hugely important.

https://theconversation.com/metal-pollution-is-leaving-scallops-hel...

A Modem With a Tiny Mirror Cabinet Could Help Connect The Quantum Internet

Quantum physics promises huge advances not just in quantum computing but also in a quantum internet – a next-generation framework for transferring data from one place to another. Scientists have now invented technology suitable for a quantum modem that could act as a network gateway.

https://journals.aps.org/prx/abstract/10.1103/PhysRevX.10.041025

https://www.sciencealert.com/physicists-invent-a-modem-that-could-h...

Salamanders provide a model for spinal-cord regeneration  
“Salamanders are unique because they are one of the only tetrapods able to regrow spinal cords with full functionality.  After an injury, these amphibians are able to “magically” regrow their spinal cords and regain locomotion.A team of scientists is looking into exactly how the process works.  The scientists plan to combine methods from genomics, neuroscience, computer modeling and biorobotics to decipher the neural mechanisms underpinning spinal-cord regeneration.https://actu.epfl.ch/news/salamanders-provide-a-model-for-spinal-co...

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A team of scientists is looking into exactly how the process works.   The scientists plan to combine methods from genomics, neuroscience, computer modeling and biorobotics to decipher the neural mechanisms underpinning spinal-cord regeneration.

New type of antivenom to reduce 100,000 fatalities each year from venomous snake bites being developed

One of the most neglected tropical problems, snakebites can be life-threatening when venom toxins are injected and enter the bloodstream attacking the blood circulatory system or nervous system. In particular, in poor and remote tropical regions where immediate access to specialised medical care is limited, venomous snake bites cause between 81,000 and 138,000 deaths and 400,000 disabilities in surviving victims each year, according to WHO estimates. Surviving snakebite victims often suffer from scars and disfigurement, and can be ostracised and discriminated against due to engrained cultural prejudice, adding to human and emotional burden.

Currently, the only known treatment is antivenom; an approach implemented in 1896 by Albert Calmette based on antibodies collected from horses and sheep that have become immune to the toxins in the venom. Although this treatment has saved many lives, it is weakly effective as snake venoms and their toxins vary significantly across all subspecies and only 10 to 15 per cent of the antibodies in the sera bind to the venom. To effect cure, multiple vials of antivenom are often needed but each additional vial induces higher levels of adverse side effects and increased treatment costs.

A new project will use the innovative ADDomer© platform to design an antivenom virus-like particle (VLP) therapy of unparalleled clinical effectiveness. Importantly, unlike antivenom which must be refrigerated, this new therapy is being developed so it can be stored at room temperature. Rapid treatment can significantly improve a victim’s chances of survival, this new advance would allow medication to be stored at local sites across the remote farming communities of sub-Saharan Africa where the disease is most prevalent.

Applying cutting-edge analysis techniques the team will sequence the complex genetic make-up of venom from the most prevalent and poisonous Sub-Saharan snakes; the saw-scaled viper, the green mamba and related species.

Using protein engineering the team will develop their unique type of snakebite treatment that can bind and neutralise the pathogenic function of all toxins of these snakes irrespective of species or geography, and without adverse effect risk that can be implemented with cost-effective technologies and requiring less manufacturing logistics. 

Scientists reveal roles of microbes on methylmercury production and degradation in rice paddy soils

Rice (Oryza sativa L.) is recently confirmed as a potential bioaccumulator plant of methylmercury (MeHg). Methylation of inorganic Hg influences the MeHg content in paddy soil, which directly affects the MeHg levels in rice seeds.

Studies on the mechanism of Hg methylation in rice paddies are significant to lower MeHg accumulation in rice and to reduce human health risks through contaminated rice consumption. MeHg cycling is mostly controlled by microbes but their importance in MeHg production and degradation in paddy soils remains unclear.

Scientists now revealed the roles of microbes in MeHg cycling in rice paddy soils. They employed a series of incubation experiments and stable isotope tracer techniques to investigate the relative importance of different microbial groups of MeHg production and degradation across a Hg contamination gradient.

The results showed that sulfate-reduction was the main driver of MeHg formation and concentration at non-contaminated sites. However, methanogenesis exhibited a complex and important role in controlling MeHg cycling at Hg mining sites.

The researchers further proposed that methanogenesis directly affected MeHg degradation via oxidative demethylation and indirectly affected MeHg production by out-competing other microbial guilds.

As a result, management of methanogenesis at Hg mining sites may shed new light on the potential for mitigation of MeHg production and reducing the risk of human exposure to MeHg.

Slow-living animal species could be disease 'reservoirs'

Animals that live slowly—breeding less rapidly and living longer—could be "reservoirs" of diseases that could jump to new species including humans, new research suggests.

Some species "live fast and die young", devoting effort to reproduction, while others conserve more energy for survival.

The COVID-19 pandemic has drawn attention to fast-spreading infectious diseases, but the new study—by the University of Exeter—focusses on "endemic" diseases that co-exist with host species for long periods of time.

The researchers measured what they called "demographic competence"—the ability of a host species to survive in large numbers while sustaining high levels of infection.

They showed that slow-lived species often have higher demographic competence for persistent infections, and are therefore more likely to act as reservoirs of infection that can spill over into other species.

Diseases of wildlife pose a threat to the survival of endangered species worldwide, and we know there is risk of spill-over of disease between closely related species of wildlife, livestock and humans. These spill-over events are known to be influenced by similarities in immune systems, and by increasing levels of contact between humans and wildlife caused by exploitation of natural ecosystems like rainforests.

As well as finding that slow-living species may be reservoirs of infectious disease, we show a 'flip-side' whereby species with low demographic competence may not be able to co-exist with new diseases and might therefore suffer local or complete extinction

It is important to note that pace-of-life in the host species isn't the only important factor affecting 'demographic competence'.

"Traits of the pathogen itself—such as how easily it is transmitted and how likely it is to kill a host—will also play a key role, as will the social behaviour of the host species.

"We must also consider the role of immunity. Differences in immune systems that we know exist between fast and slow hosts can influence how long individuals are ill and whether they can be re-infected."

Life history and population regulation shape demographic competence and influence the maintenance of endemic disease, DOI: 10.1038/s41559-020-01333-8 , www.nature.com/articles/s41559-020-01333-8

https://phys.org/news/2020-11-slow-living-animal-species-disease-re...

Wound-healing biomaterials activate immune system for stronger skin

Researchers  have developed a biomaterial that significantly reduces scar formation after wounding, leading to more effective skin healing. This new material, which quickly degrades once the wound has closed, demonstrates that activating an adaptive immune response can trigger regenerative wound healing, leaving behind stronger and healthier healed skin.

This work builds on the team's previous research with hydrogel scaffolds, which create a structure to support tissue growth, accelerating wound healing. In their new study, the team showed that a modified version of this hydrogel activates a regenerative immune response, which can potentially help heal skin injuries like burns, cuts, diabetic ulcers and other wounds that normally heal with significant scars that are more susceptible to reinjury.

Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing, Nature Materials (2020). DOI: 10.1038/s41563-020-00844-w , www.nature.com/articles/s41563-020-00844-w

https://phys.org/news/2020-11-wound-healing-biomaterials-immune-str...

India's clean fuel transition slowed by belief that firewood is better for well-being

India's transition to clean cooking fuels may be hampered by users' belief that using firewood is better for their families' wellbeing than switching to Liquefied Petroleum Gas (LPG), a new study reveals.

Women are considered primary family cooks in rural India and those featured in the study feel that both fuels support wellbeing. Understanding these viewpoints helps to explain why India's switch from traditional solid fuels is slower than expected.

Those cooks using firewood know it causes health problems, but feel that it contributes more to wellbeing than cooking with LPG would—although LPG users who previously cooked with firewood claim their new fuel has improved wellbeing.

India has more people relying on solid fuels for cooking than any other country in the world and providing universal access to clean cooking fuels has been identified as one of the UN's Sustainable Development Goals (SDGs), to which the country is a signatory.

The study identifies three key lessons that have important implications for policy makers to consider:

• Users feel that both fuels support at least some key dimensions of wellbeing

  Understanding this helps to explain why people may not be persuaded to switch to cleaner fuels based only on seemingly obvious health benefits.

• Women's views on cooking fuels and wellbeing change after switching fuels.

  LPG and firewood users share some views, such as food tastes better cooked on firewood, but LPG users see more advantages in LPG than non-users.

• Wellbeing benefits of LPG use were based on time saved over using firewood

Differences in firewood users' and LPG users' perceived relationships between cooking fuels and women's multidimensional well-being in rural India, Nature Energy (2020). DOI: 10.1038/s41560-020-00722-4 , www.nature.com/articles/s41560-020-00722-4

https://techxplore.com/news/2020-11-india-fuel-transition-belief-fi...

New robotic ‘snake’ device grips, picks up objects

New tool detects unsafe security practices in Android apps

"CRYLOGGER: Detecting Crypto Misuses Dynamically." DOI: 10.1109/SP40001.2021.00010 , www.computer.org/csdl/proceedi … 3400a160/1mbmHwIxTb2

https://techxplore.com/news/2020-11-tool-unsafe-android-apps.html?u...

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Scientists criticize use of unproven COVID drugs in India

Possible drug treatment on horizon for SARS-CoV-2 virus

Researchers from the Universities of York and Melbourne have shed new light on how viruses like hepatitis B, dengue and SARS-CoV-2 hijack a cell paving the way for potential anti-viral drugs to stop the virus in its tracks. Like products on a factory assembly line, all proteins pass through quality control checkpoints where they are inspected before they are transported to their destination to carry out their functions. The researchers showed that some viruses could hijack this manufacturing and distribution process in the cell. The virus can use the cells machinery to copy their DNA or RNA and produce the proteins they need to make copies of themselves and take-over their host. Research demonstrated that viruses tend to harness a step in this process where sugar molecules coat newly assembled proteins. The team was able to develop inhibitors to block an enzyme that trims, checks, and modifies the sugar coating process, which can disrupt the viruses’ ability to hijack the pathway.

https://www.york.ac.uk/news-and-events/news/2020/research/possible-...

https://researchnews.cc/news/3481/Possible-drug-treatment-on-horizo...

First-Ever Flu Vaccine Derived From Tobacco Plants Just Smashed Clinical Trials

A new flu vaccine grown in plants has been put to the test in two large-scale clinical trials, a first for vaccine research.

The vaccine contained virus-like particles which resembled circulating flu strains, extracted from native Australian tobacco relatives that were genetically instructed to produce the viral proteins.

The two trials combined involved nearly 23,000 people and the results suggest that the plant-derived vaccine is not only safe, but comparable to current commercial flu vaccines.

To the best of our knowledge, these studies and the clinical development programme that preceded them are the largest demonstration to date of the potential for a plant-based platform to produce a human vaccine that can be safe, immunogenic, and effective.

Most influenza vaccines are currently made using virus particles grown in and harvested from chicken eggs or lab-grown cells, which takes months even after scientists work out which flu strains (and surface proteins) they need to target.

Plants, which can be engineered to produce select proteins and cultivated at scale, could be an alternative, helping to boost our capacity to produce seasonal flu vaccines.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32014-6/fulltext

https://www.sciencealert.com/large-scale-studies-test-flu-vaccine-d...

Radioactive elements may be crucial to the habitability of rocky planets

The amount of long-lived radioactive elements incorporated into a rocky planet as it forms may be a crucial factor in determining its future habitability, according to a new study by an interdisciplinary team of scientists.

 That's because internal heating from the radioactive decay of the heavy elements thorium and uranium drives plate tectonics and may be necessary for the planet to generate a magnetic field. Earth's magnetic field protects the planet from solar winds and cosmic rays.

Convection in Earth's molten metallic core creates an internal dynamo (the "geodynamo") that generates the planet's magnetic field. Earth's supply of radioactive elements provides more than enough internal heating to generate a persistent geodynamo.

Different planets accumulate different amounts of these radioactive elements that ultimately power geological activity and the magnetic field. I

if the radiogenic heating is more than the Earth's, the planet can't permanently sustain a dynamo, as Earth has done. That happens because most of the thorium and uranium end up in the mantle, and too much heat in the mantle acts as an insulator, preventing the molten core from losing heat fast enough to generate the convective motions that produce the magnetic field.

With more radiogenic internal heating, the planet also has much more volcanic activity, which could produce frequent mass extinction events. On the other hand, too little radioactive heat results in no volcanism and a geologically "dead" planet.

It has long been speculated that internal heating drives plate tectonics, which creates carbon cycling and geological activity like volcanism, which produces an atmosphere. And the ability to retain an atmosphere is related to the magnetic field, which is also driven by internal heating.

The heavy elements crucial to radiogenic heating are created during mergers of neutron stars, which are extremely rare events. 

 Francis Nimmo et al. Radiogenic Heating and Its Influence on Rocky Planet Dynamos and Habitability, The Astrophysical Journal (2020). DOI: 10.3847/2041-8213/abc251

https://phys.org/news/2020-11-radioactive-elements-crucial-habitabi...

Researchers isolate and decode brain signal patterns for specific behaviours

Brain signals contain dynamic neural patterns that reflect a combination of  activities simultaneously. A standing challenge has been isolating those patterns in brain signals that relate to a specific behaviour, such as finger movements. Further, developing brain-machine interfaces (BMIs) that help people with neurological and mental disorders requires the translation of brain signals into a specific behaviour, a problem called decoding. This decoding also depends on our ability to isolate neural patterns related to specific behaviours. These neural patterns can be masked by patterns related to other activities and can be missed by standard algorithms.

Researchers have developed a machine learning algorithm that resolved the above challenge. The algorithm  uncovered neural patterns missed by other methods and enhanced the decoding of behaviours that originated from signals in the brain. This algorithm is a significant advance in modeling and decoding of complex brain activity which could both enable new neuroscience discoveries and enhance future brain-machine interfaces.

Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification, Nature Neuroscience (2020). DOI: 10.1038/s41593-020-00733-0 , www.nature.com/articles/s41593-020-00733-0

https://medicalxpress.com/news/2020-11-isolate-decode-brain-pattern...

Chemicals in your living room cause diabetes

A new  study shows flame retardants  in  homes cause mice to give birth to offspring that become diabetic.

PBDEs are common household chemicals added to furniture, upholstery, and electronics to prevent fires. They get released into the air people breathe at home, in their cars, and in airplanes because their chemical bond to surfaces is weak.

"PBDEs are everywhere in the home. They're impossible to completely avoid

These flame retardants, called PBDEs, have been associated with diabetes in adult humans. This study demonstrates that PBDEs cause diabetes in mice only exposed to the chemical through their mothers.

The mice received PBDEs from their mothers while they were in the womb and as young babies through mother's milk. Remarkably, in adulthood, long after the exposure to the chemicals, the female offspring developed diabetes.

Elena V. Kozlova et al, Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring, Scientific Reports (2020). DOI: 10.1038/s41598-020-74853-9

https://medicalxpress.com/news/2020-11-chemicals-room-diabetes.html...

Nanomedicine crosses into brain, eradicates recurring brain cancer in mice

A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier could deliver cancer-killing drugs directly to malignant brain tumours, new research  shows.

The study is the first to demonstrate an intravenous medication that can cross the blood-brain barrier.

The discovery, demonstrated in mice, could enable new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults, and one whose incidence is rising in many countries.T oday's median survival for patients with glioblastoma is around 18 months; the average 5-year survival rate is below 5%.

In combination with radiation, the U-M team's intravenously-injected therapy led to long-term survival in seven out of eight mice. When those seven mice experienced a recurrence of glioblastoma, their immune responses kicked in to prevent the cancer's regrowth—without any additional therapeutic drugs or other clinical treatments.

The findings suggest that the U-M team's combination of therapeutic drugs and nanoparticle delivery methods not only eradicated the primary  tumour but resulted in immunological memory, or the ability to more quickly recognize—and attack—remaining malignant cancer cells.

Jason V. Gregory et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy, Nature Communications (2020). DOI: 10.1038/s41467-020-19225-7

https://phys.org/news/2020-11-nanomedicine-brain-eradicates-recurri...

Scientists use bacteria as micro-3-D printers

A team at Aalto University has used bacteria to produce intricately designed three-dimensional objects made of nanocellulose. With their technique, the researchers are able to guide the growth of bacterial colonies through the use of strongly water repellent—or superhydrophobic—surfaces. The objects show tremendous potential for medical use, including supporting tissue regeneration or as scaffolds to replace damaged organs.

Unlike fibrous objects made through current 3-D printing methods, the new technique allows fibers, with a diameter a thousand times thinner than a human hair, to be aligned in any orientation, even across layers, and various gradients of thickness and topography, opening up new possibilities for application in tissue regeneration. These kinds of physical characteristics are crucial for support materials in the growth and regeneration of certain types of tissues found in muscles as well as in the brain.

Luiz G. Greca et al, Guiding Bacterial Activity for Biofabrication of Complex Materials via Controlled Wetting of Superhydrophobic Surfaces, ACS Nano (2020). DOI: 10.1021/acsnano.0c03999

https://phys.org/news/2020-11-scientists-bacteria-micro-d-printers....

Scientists have discovered an ancient lake bed deep beneath the Greenland ice

Scientists have detected what they say are the sediments of a huge ancient lake bed sealed more than a mile under the ice of northwest Greenland—the first-ever discovery of such a sub-glacial feature anywhere in the world. Apparently formed at a time when the area was ice-free but now completely frozen in, the lake bed may be hundreds of thousands or millions of years old, and contain unique fossil and chemical traces of past climates and life. 

Guy J.G. Paxman et al. A fault-bounded palaeo-lake basin preserved beneath the Greenland Ice Sheet, Earth and Planetary Science Letters (2020). DOI: 10.1016/j.epsl.2020.116647

https://phys.org/news/2020-11-scientists-ancient-lake-bed-deep.html...

Study identifies new 'hidden' gene in COVID-19 virus

Researchers have discovered a new "hidden" gene in SARS-CoV-2—the virus that causes COVID-19—that may have contributed to its unique biology and pandemic potential. In a virus that only has about 15 genes in total, knowing more about this and other overlapping genes—or "genes within genes"—could have a significant impact on how we combat the virus.

Overlapping genes may be one of an arsenal of ways in which coronaviruses have evolved to replicate efficiently, thwart host immunity, or get themselves transmitted. Knowing that overlapping genes exist and how they function may reveal new avenues for corona virus control, for example through antiviral drugs.

The research team identified ORF3d, a new overlapping gene in SARS-CoV-2 that has the potential to encode a protein that is longer than expected by chance alone. They found that this gene is also present in a previously discovered pangolin coronavirus, perhaps reflecting repeated loss or gain of this gene during the evolution of SARS-CoV-2 and related viruses. In addition, ORF3d has been independently identified and shown to elicit a strong antibody response in COVID-19 patients, demonstrating that the new gene's protein is manufactured during human infection.

Chase W Nelson et al, Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic, eLife (2020). DOI: 10.7554/eLife.59633

https://phys.org/news/2020-11-hidden-gene-covid-virus.html

Why bats fly into walls

Bats excel in acoustic perception and detect objects as tiny as mosquitoes using sound waves. Echolocation permits them to calculate the three-dimensional location of both small and large objects, perceiving their shape, size and texture. To this end, a bat's brain processes acoustic dimensions such as frequency, spectrum and intensity from the echoes returning from the object.

But sometimes bats collide with large walls even though they detect these walls with their sonar system. Researchers from Tel Aviv University (TAU) have concluded that these collisions do not result from a sensory limitation but rather from an error in acoustic perception.

 The researchers discovered that the bats collided with large sponge walls that produce a weak echo as if they did not exist. The bats' behaviour suggested that they did this even though they had detected the wall with their sonar system, indicating that the collision did not result from a sensory limitation, but rather from an acoustic misperception.

The researchers hypothesize that the unnatural combination of a large object and a weak echo disrupts the bats' sensory perception and causes them to ignore the obstacle, much like people who bump into transparent walls.

The researchers then methodically changed the features of the objects along the corridor, varying their size, texture and echo intensity. They concluded that the bats' acoustic perception depends on a coherent, typical correlation of the dimensions with objects in nature—that a large object should produce a strong echo and a small object a weak echo.

By presenting the bats with objects whose acoustic dimensions are not coherent, we were able to mislead them, creating a misconception that caused them to repeatedly try to fly into a wall even though they had identified it with their sonar. The experiment gives us a peek into how the world is perceived by these creatures, whose senses are so unique and different from ours.

Sasha Danilovich et al, Echolocating bats detect but misperceive a multidimensional incongruent acoustic stimulus, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.2005009117

https://phys.org/news/2020-11-walls.html

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Fruit bats can transform echoes into images

https://phys.org/news/2019-06-fruit-echoes-images.html

A new candidate material for Quantum Spin Liquids

 In 1973, physicist and later Nobel laureate Philip W. Anderson proposed a bizarre state of matter: the quantum spin liquid (QSL). Unlike the everyday liquids we know, the QSL actually has to do with magnetism – and magnetism has to do with spin.

What makes a magnet? It was a long-lasting mystery, but today we finally know that magnetism arises from a peculiar property of sub-atomic particles, like electrons. That property is called “spin”, and the best – yet grossly insufficient – way to think of it is like a child’s spinning-top toy.

What is important for magnetism is that spin turns every one of a material’s billions of electrons into a tiny magnet with its own magnetic “direction” (think north and south pole of a magnet). But the electron spins aren’t isolated; they interact with each other in different ways until they stabilize to form various magnetic states, thereby granting the material they belong to magnetic properties.

In a conventional magnet, the interacting spins stabilize, and the magnetic directions of each electron align. This results in a stable formation.

But in what is known as a “frustrated” magnet, the electron spins can’t stabilize in the same direction. Instead, they constantly fluctuate like a liquid – hence the name “quantum spin liquid.”

What is exciting about QSLs is that they can be used in a number of applications. Because they come in different varieties with different properties, QSLs can be used in quantum computing, telecommunications, superconductors, spintronics (a variation of electronics that uses electron spin instead of current), and a host of other quantum-based technologies.

But before exploiting them, we first have to gain a solid understanding of QSL states. To do this, scientists have to find ways to produce QSLs on demand.

 Scientists have successfully produced and studied a QSL in a highly original material known as EDT-BCO.

The structure of EDT-BCO is what makes it possible to create a QSL. The electron spins in the EDT-BCO form triangularly organized dimers, each of which has a spin-1/2 magnetic moment which means that the electron must fully rotate twice to return to its initial configuration. The layers of spin-1/2 dimers are separated by a sublattice of carboxylate anions centred by a chiral bicyclooctane. The anions are called “rotors” because they have conformational and rotational degrees of freedom.

The unique rotor component in a magnetic system makes the material special amongst QSL candidates, representing a new material family. “The subtle disorder provoked by the rotor components introduces a new handle upon the spin system.

The scientists and their collaborators employed an arsenal of methods to explore the EDT-BCO as a QSL material candidate: density functional theory calculations, high-frequency electron spin resonance measurements, nuclear magnetic resonance, and muon spin spectroscopy. All of these techniques explore the magnetic properties of EDT-BCO from different angles.

All the techniques confirmed the absence of long-range magnetic order and the emergence of a QSL. In short, EDT-BCO officially joins the limited ranks of QSL materials and takes us a step further into the next generation of technologies.

https://actu.epfl.ch/news/a-new-candidate-material-for-quantum-spin...

https://researchnews.cc/news/3511/A-new-candidate-material-for-Quan...

Researchers discover two key events that turn normal cells into cancer

More than 100 different cancers can arise all over the body, but two universal metabolic pathways may tie them all together, researchers report in a new study published today online in Cell Metabolism. Researchers have long believed all cancers are governed by a common set of fundamental processes. Exactly what those were, however, has remained elusive.

Having a unifying mechanism could inform new therapeutic approaches to prevent normal cells from transforming into any type of tumour, be it breast, prostate, or colon, for example.

The team discovered how the transformation from a phenotypically normal cell to a cancerous one involves the enhancement of two key elements: antioxidant defense and nucleotide synthesis. Genes associated with cancer, they found, are super charging some cells to fight off oxidative stress and synthesize nucleotides, which cells need to survive and rapidly grow, respectively.

The researchers first overexpressed the gene G6PD, which makes the enzyme glucose-6-phosphate dehydrogenase, in mice and human cells. That enzyme is active in nearly all cells in the body and involved in the normal processing of carbohydrates. They showed that this overexpression alone turned human cells cancerous and led to tumors in the mice.

Next, they analyzed the mechanisms involved in that overexpression to pinpoint what pathways were critical to the transformation. They found that G6PD stimulates production of new NADPH, a crucial co-enzyme for maintaining redox balance (which keeps the cell from being damaged and dying off), as well as more nucleotide precursors to keep them multiplying. Under conditions that elicit oxidative stress, which are often encountered by cancer cells due to their relentless proliferation, often in a wrong place, a normal cell would buckle, but a cancer cell armed with these additions presses on.

The findings also lend further evidence shown in clinical trials and other studies that antioxidants in fact support tumor growth, not decrease it. For a tumor to form, it needs a robust antioxidant defense; giving it more antioxidants provides an ideal environment for it to do that. The findings also provide an explanation for the observation that compounds interfering with nucleotide biosynthesis are among the most successful chemotherapeutic drugs for cancer.

Importantly, the study reveals a molecular framework to better understand the process of oncogenesis and a potential road map for new approaches to treat cancer, the authors said.

Now we can say that the oncogenic transformation comes from two fundamental steps. “Our study also suggests that combining therapeutics that affect both events, some which are already in clinics, would be more effective at preventing normal cells from becoming cancerous.

https://www.pennmedicine.org/news/news-releases/2020/november/penn-...

https://researchnews.cc/news/3504/Penn-researchers-discover-two-key...

How do we reduce the risk of animal viruses jumping to humans?

Radioactive: new Marie Curie biopic inspires, but resonates uneasily for women in science

https://theconversation.com/radioactive-new-marie-curie-biopic-insp...

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How memorable melodies can make your research sing

What Happens When You Overcharge A Battery Understanding what causes dendrites in lithium-ion batteries could help make the ubiquitous technology safer. https://www.asianscientist.com/2020/11/tech/battery-overcharge-lith...

Scientists Just Discovered  over 12,000 New Species of Microbes

Growing microbes in a petri dish is pretty simple – swab basically anything, wipe it on an agar plate, let it sit for a few days in a warm room and presto! You've grown some new furry friends.

But the microbial species you can cultivate in a petri dish are only a tiny fraction of the bacteria, archaea and other microorganisms that would have been picked up by the swab - only the ones suited to the conditions you grew them in.

The overwhelming majority of them do not like the environments we can provide, and therefore won't obediently grow in a petri dish.

Now, an international team of researchers has found 12,556 new species of bacteria and archaea that have never been grown in a lab, using an incredibly cool technique called metagenomics.

"We were able to reconstruct thousands of metagenome-assembled genomes (MAGs) directly from sequenced environmental samples without needing to cultivate the microbes in the lab," said DOE Joint Genome Institute geneticist and first author, Stephen Nayfach.

"What makes this study really stand out from previous efforts is the remarkable environmental diversity of the samples we analysed."

https://www.sciencealert.com/scientists-have-just-uncovered-12-000-...

https://www.nature.com/articles/s41587-020-0718-6

https://phys.org/news/2020-11-scientists-genomes-birds-avian-famili...

Tableware made from sugarcane and bamboo breaks down in 60 days

Scientists have designed a set of "green" tableware made from sugarcane  and bamboo that doesn't sacrifice on convenience or functionality and could serve as a potential alternative to plastic cups and other disposable plastic containers. Unlike traditional plastic or biodegradable polymers—which can take as long as 450 years or require high temperatures to degrade—this non-toxic, eco-friendly material only takes 60 days to break down and is clean enough to hold your morning coffee or dinner takeout.

To find an alternative for plastic-based food containers, researchers turned to bamboos and one of the largest food-industry waste products: bagasse, also known as sugarcane pulp. Winding together long and thin bamboo fibers with short and thick bagasse fibers to form a tight network, the team molded containers from the two materials that were mechanically stable and biodegradable. The new green tableware is not only strong enough to hold liquids as plastic does and cleaner than biodegradables made from recycled materials that might not be fully de-inked, but also starts decomposing after being in the soil for 30-45 days and completely loses its shape after 60 days.

The researchers added alkyl ketene dimer (AKD), a widely used eco-friendly chemical in the food industry, to increase oil and water resistance of the molded tableware, ensuring the sturdiness of the product when wet. With the addition of this ingredient, the new tableware outperformed commercial biodegradable food containers, such as other bagasse-based tableware and egg cartons, in mechanical strength, grease resistance, and non-toxicity.

The tableware the researchers developed also comes with another advantage: a significantly smaller carbon footprint. The new product's manufacturing process emits 97% less CO2 than commercially available plastic containers and 65% less CO2 than paper products and biodegradable plastic. 

 Matter, Liu, Luan, and Li et al.: "Biodegradable, Hygienic, and Compostable Tableware from Hybrid Sugarcane and Bamboo Fibers as Plastic Alternative" www.cell.com/matter/fulltext/S2590-2385(20)30558-0 , DOI: 10.1016/j.matt.2020.10.004

https://phys.org/news/2020-11-tableware-sugarcane-bamboo-days.html?...

Evolution favours new diseases of 'intermediate' severity

New epidemic diseases have an evolutionary advantage if they are of "intermediate" severity, research shows.

Scientists tested the theory that pathogens (disease-causing organisms) that inflict intermediate levels of harm on their host are the most evolutionarily successful.

found that natural selection favors pathogens of intermediate virulence (how much harm a pathogen causes) at the point the disease emerges in a new host species.

This occurs because virulence and transmission are linked, with virulence arising because pathogens need to exploit hosts to persist, replicate and transmit.

While too-low virulence will be detrimental for pathogens if they cannot transmit, virulence that is too high will also be a disadvantage if infection kills hosts so fast that the pathogen does not have time to transmit.

Over time, pathogens that show intermediate levels of virulence should therefore have an evolutionary advantage.

Camille Bonneaud et al, Experimental evidence for stabilizing selection on virulence in a bacterial pathogen, Evolution Letters (2020). DOI: 10.1002/evl3.203

https://phys.org/news/2020-11-evolution-favors-diseases-intermediat...

Researchers find connection between household chemicals and gut microbiome

A team of researchers for the first time has found a correlation between the levels of bacteria and fungi in the gastrointestinal tract of children and the amount of common chemicals found in their home environment.

The work could lead to better understanding of how these semi-volatile organic compounds may affect human health.

The microbes in our gut, which include a large variety of bacteria and fungi, are thought to affect many processes, from nutrient absorption to our immunity, and an unhealthy microbiome has been implicated in diseases ranging from obesity to asthma and dementia.

In the study, the researchers measured levels of ubiquitous semi-organic compounds in the blood and urine of 69 toddlers and preschoolers and then, using fecal samples, studied the children's gut microbiomes. The semi-volatile organic compounds they measured included phthalates that are used in detergents, plastic clothing such as raincoats, shower curtains, and personal-care products, such as soap, shampoo, and hair spray, as well as per- and polyfluoroalkyl substances (PFASs), which are used in stain- and water-repellent fabrics, coatings for carpets and furniture, nonstick cooking products, polishes, paints, and cleaning products. People are exposed daily to such chemicals in the air and dust in their homes, especially young children who might ingest them by crawling on carpets or frequently putting objects in their mouths.

When the researchers looked at the levels of fungi and bacteria in the gut, they found that children who had higher levels of the chemicals in their bloodstream showed differences in their gut microbiome.

Children with higher levels of PFASs in their blood had a reduction in the amount and diversity of bacteria, while increased levels of phthalates were associated with a reduction in fungi populations.

The correlation between the chemicals and less abundant bacterial organisms was especially pronounced and potentially most concerning.

The researchers also found, surprisingly, that the children who had high levels of chemical compounds in their blood also had in their gut several types of bacteria that have been used to clean up toxic chemicals. Dehalogenating bacteria have been used for bioremediation to degrade persistent halogenated chemicals like dry cleaning solvents from the environment. These bacteria are not typically found in the human gut.

"Finding the increased levels of these type of bacteria in the gut means that, potentially, the gut microbiome is trying to correct itself.

 Courtney M. Gardner et al, Exposures to Semivolatile Organic Compounds in Indoor Environments and Associations with the Gut Microbiomes of Children, Environmental Science & Technology Letters (2020). DOI: 10.1021/acs.estlett.0c00776

https://medicalxpress.com/news/2020-11-household-chemicals-gut-micr...

A potential game-changer to reverse alcohol intoxication

A staggering 3 million deaths occur every year as result from harmful use of alcohol, according to the World Health Organization.

Present in alcoholic drinks, ethanol, normally referred to as 'alcohol', affects every part of the human body. Brain function, circulation and even nail growth are impacted. When a certain level of blood alcohol concentration is reached, the intoxication can damage organs and lead to death.

Now a team of researchers  presents a proof of concept of a simple method that could become a game-changer in rescue therapy for severe alcohol intoxication, as well as just "sobering up."

Normally, 90% of the alcohol in the human body is cleared exclusively by the liver at constant rate that can't be increased. Currently there is no other method, short of dialysis, whereby alcohol can be removed from the blood. This leaves as the only options to treat life-threatening alcohol levels supportive measures such as giving oxygen, intravenous fluids, breathing assistance, and treating any heart issues with drugs.

The principle behind UHN team's approach is simply to recruit the lungs to breathe out the alcohol. The harder the breathing, it was reasoned, the more alcohol is eliminated. The team found that indeed, hyperventilation eliminated the alcohol at least three times faster than through the liver alone. But you can't just hyperventilate, because in a minute or two you would become light-headed and pass out.

When hyperventilating—breathing deeper and more rapidly than normal—the body eliminates carbon dioxide from the blood along with the alcohol. The decrease of this gas in the blood is the cause of symptoms such as light-headedness, tingling or numbness on hands and feet, and fainting.

The device used in this study allows the patient to hyperventilate off the alcohol while returning precisely the amount of carbon dioxide to the body to keep it at normal levels in the blood—regardless of the extent of hyperventilation. The equipment is the size of a small briefcase and uses a valve system, some connecting tubes, a mask, and a small tank with compressed carbon dioxide.

Scientific Reports (2020). DOI: 10.1038/s41598-020-76233-9

https://medicalxpress.com/news/2020-11-potential-game-changer-rever...

At the moment the quickest superbug diagnosis time is around 24 hours. Now new research has identified a way of completing the whole blood sampling and analysis process in the space of just one hour.

Researchers from across the fields of molecular biology, chemistry, integrated optics and chemical processing put their heads together to come up with the new process, which can look out for three different superbugs in one go.

Through a process of blood spinning, the bacteria are isolated from the samples so their DNA can be analysed. The researchers used fluorescent molecules designed to bind specifically to segments of bacterial DNA that contain known antibiotic resistant genes. If these genes were present in the sample, they could then be detected by a microchip.

Every hour the disease is untreated, survivability drops by about 7 percent. You want to know what you're fighting immediately so you can apply the right treatments. 

https://pubs.rsc.org/en/content/articlelanding/2020/lc/d0lc00640h#!...

 https://www.sciencealert.com/new-test-can-spot-superbugs-in-your-bl...

New device puts music in your head—no headphones required

Imagine a world where you move around in your own personal sound bubble. You listen to your favorite tunes, play loud computer games, watch a movie or get navigation directions in your car—all without disturbing those around you.

That's the possibility presented by "sound beaming," a new futuristic audio technology from Noveto Systems. On Friday it  debuted a desktop device that beams sound directly to a listener without the need for headphones.

The listening sensation is straight out of a sci-fi movie. The 3-D sound is so close it feels like it's inside your ears while also in front, above and behind them.

Noveto expects the device will have plenty of practical uses, from allowing office workers to listen to music or conference calls without interrupting colleagues to letting someone play a game, movie or music without disturbing their significant others.

The lack of headphones means it's possible to hear other sounds in the room clearly.

The technology uses a 3-D sensing module and locates and tracks the ear position sending audio via ultrasonic waves to create sound pockets by the user's ears. Sound can be heard in stereo or a spatial 3-D mode that creates 360 degree sound around the listener, the company said.

The demo includes nature video clips of swans on a lake, bees buzzing and a babbling brook, where the listener feels completely transported into the scene.

You don't believe it because it sounds like a speaker, but no one else can hear it…it's supporting you and you're in the middle of everything. It's happening around you."

By changing a setting, the sound can follow a listener around when they move their head. It's also possible to move out of the beam's path and hear nothing at all, which creates a surreal experience.

It follows you wherever you go. So it's personally for you—follows you, plays what you want inside your head.

https://techxplore.com/news/2020-11-device-music-headno-headphones-...

Scientists race for hail collection for research

COVID-19 vaccines are coming – how will we know they work and are safe?

https://theconversation.com/covid-19-vaccines-are-coming-how-will-w...

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why do older adults get shorter?

It's not just older adults who get shorter. You start shrinking, the moment you get out of bed in the morning.

https://theconversation.com/curious-kids-why-do-older-adults-get-sh...

In-utero exposure to coronavirus pandemic could cause developmental difficulties, accelerated aging in the century ahead

Exposure to COVID-19 could pose a risk to the health and aging of individuals who aren't even born yet, according to a newly published analysis by USC researchers.

by the end of 2020, approximately 300,000 infants could be born to mothers infected by SARS-CoV-2, the virus that causes COVID-19. Millions more will be born into families who have experienced tremendous stress and upheaval due to the pandemic even if they haven't been infected themselves, the authors added.

While the longer-term effects of COVID-19 on infants is yet to be seen, researchers can find some insight from the past, including the 1918 flu pandemic and previous coronavirus illnesses such as SARS in 2002 and MERS in 2012, Finch said.

"The 1918 influenza pandemic had long-term impacts on the cohort exposed in utero, which experienced earlier adult mortality and more diabetes, ischemic heart disease and depression after age 50," he said. "It is possible that the COVID-19 pandemic will also have long-term impacts on the cohort that was in utero during the pandemic, from exposure to maternal infection and/or the stress of the pandemic environment."

Maternal viral infections can affect fetuses through multiple pathways, from direct transmission through the placenta to inflammatory responses that disturb in-utero metabolism a

nd negatively affect growth. While direct maternal-fetal transmission of the virus and severe birth defects appear to have been rare during previous coronavirus outbreaks, there were increases in preterm delivery and low birth weight during both the 2002 SARS and 2009 H1N1 influenza outbreaks, which are possible consequences of increased inflammation.

While studies on COVID-19 and pregnancy are still in their early stages, there have already been some concerning results that merit a closer look in ongoing studies, the authors wrote. Increased rates of preterm birth may be linked to maternal SARS-CoV-2 infections, and other studies indicate that severe illness is correlated with a higher risk of stillbirth. Other potential dangers, including the increased risk of blood clots presented by both pregnancy and severe COVID-19, also need further study.

Molly Crimmins Easterlin et al, Will prenatal exposure to SARS-CoV-2 define a birth cohort with accelerated aging in the century ahead?, Journal of Developmental Origins of Health and Disease (2020). DOI: 10.1017/S204017442000104X

https://medicalxpress.com/news/2020-11-in-utero-exposure-coronaviru...