Astronomers May Have Detected The First Radio Signal From an Exoplanet

https://www.sciencealert.com/astronomers-detect-the-first-potential...

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These Arctic squirrels recycle bits of their own bodies to survive winter

The secrets of the animals’ metabolism during hibernation could someday help human medicine

S.A. Rice et al. Nitrogen recycling buffers against ammonia toxicity from skeletal m.... Nature Metabolism. Published online December 7, 2020. doi: 10.1038/s42255-020-00312-4.

https://www.sciencenews.org/article/arctic-squirrels-recycle-protei...

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Scientists take a step towards expanding the use of magnetic fluids...

Magnetic fluids are used in many different areas, including medicine, electronics, mechanical engineering, ecology, etc. Such a wide range of applications is explained by a number of its useful properties. Researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) in collaboration with colleagues from Jiangsu Normal University (JSNU) discovered new effects in magnetic fluids, which will increase its effectiveness for medical purposes in future. The results were published in Springer Proceedings in Physics.

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When light and atoms share a common vibe

An especially counter-intuitive feature of quantum mechanics is that a single event can exist in a state of superposition—happening both here and there, or both today and tomorrow.

Science behind miracles

Exploring the role of prefrontal-amygdala brain circuits in social decision-making

In recent years, neuroscientists have been trying to understand the neural underpinnings of social behaviors and cognition. Studies on animal species, including primates and rodents, have identified a number of brain regions and neural circuits that may underpin social behaviors.

Researchers a have been conducting extensive research investigating the roles of the medial prefrontal cortex and the amygdala in social decision-making, particularly focusing on the interactions between different brain regions in the prefrontal-amygdala pathways. In a recent paper published in Nature Neuroscience, the researchers reviewed and summarized the evidence gathered in past studies that examined the neural mechanisms of social decision-making in humans, non-human primates and rodents.

Overall, the findings reviewed  the researchers highlight the crucial role of interactions between the medial prefrontal cortex and amygdala in the social cognition of a wide variety of animal species. The medial prefrontal cortex has previously been found to contribute to a number of sensorimotor, cognitive and emotional processes, while the amygdala is a region deep within the brain that integrates a number of emotions, emotional reactions and motivations.

Some recent studies also revealed that neural ensembles involved in the processing of information that is both related and unrelated to social communication can interact with one another. These interactions appear to facilitate or attenuate social functions, increasing or decreasing their prevalence over non-social functions.

 Prefrontal-amygdala circuits in social decision-making. Nature Neuroscience (2020). DOI: 10.1038/s41593-020-00738-9

https://medicalxpress.com/news/2020-12-exploring-role-prefrontal-am...

SARS-CoV-2-like particles very sensitive to temperature

Why do corona viruses become more active in winter?

A new study tested how temperatures and humidity affect the structure of individual SARS-Cov-2 virus-like particles on surfaces. They found that just moderate temperature increases broke down the virus' structure, while humidity had very little impact. In order to remain infectious, the SARS-Cov-2 membrane needs a specific web of proteins arranged in a particular order. When that structure falls apart, it becomes less infectious. The findings suggest that as temperatures begin to drop, particles on surfaces will remain infectious longer.

This is the first study to analyze the mechanics of the virus on an individual particle level, but the findings agree with large-scale observations of other coronaviruses that appear to infect more people during the winter months.

Temperature makes a huge difference, and that's what the researchers saw. To the point where the packaging of the virus was completely destroyed by even moderate temperature increases. They 

hey tested the virus-like particles on glass surfaces under both dry and humid conditions. Using atomic force microscopy they observed how, if at all, the structures changed. The scientists exposed samples to various temperatures under two conditions: with the particles inside a liquid buffer solution, and with the particles dried out in the open. In both liquid and bare conditions, elevating the temperature to about 93 degrees F for 30 minutes degraded the outer structure. The effect was stronger on the dry particles than on the liquid-protected ones. In contrast, surfaces at about 71 degrees F caused little to no damage, suggesting that particles in room temperature conditions or outside in cooler weather will remain infectious longer.

They saw very little difference under levels of humidity on surfaces, however the scientists stress that humidity likely does matter when the particles are in the air by affecting how fast the aerosols dry out. The research team is continuing to study the molecular details of virus-like particle degradation.

A. Sharma et al, Structural stability of SARS-CoV-2 virus like particles degrades with temperature, Biochemical and Biophysical Research Communications (2020). DOI: 10.1016/j.bbrc.2020.11.080

** https://medicalxpress.com/news/2020-12-sars-cov-like-particles-sens...

Forensic science: laser technique distinguishes human and animal blood

New research published recently could soon offer law enforcement another valuable crime scene tool—a quick and accurate way to distinguish human blood from animal blood.

In a proof-of-concept study researchers used laser technology to rapidly differentiate human blood samples from nearly a dozen animal species.

This could prove to be key in car crash investigations when the suspect is unsure if a human or animal was struck.

technique relies on Raman spectroscopy, which works by shining a laser on a dry blood sample and measuring the interaction. No two samples produce the same results, offering a unique measurement (similar to a fingerprint). The results are instantaneous and do not destroy the sample, preserving it for future testing.

In the new study researchers used attenuated total reflection Fourier transform-infrared (ATR FT-IR) spectroscopy, a complementary technique to Raman spectroscopy, on 15 human blood samples and a total of 89 cat, dog, rabbit, horse, cow, pig, opossum and raccoon blood samples. Although each sample  appeared nearly identical to the naked eye, the ATR FT-IR spectroscopy analysis, coupled with advanced statistics, was able to classify them as human or animal with 100 percent accuracy.

Samples from three other species—deer, elk and ferret—were included to further test the statistical model, and were all correctly classified.

Ewelina Mistek-Morabito et al. Discrimination between human and animal blood by attenuated total reflection Fourier transform-infrared spectroscopy, Communications Chemistry (2020). DOI: 10.1038/s42004-020-00424-8

https://phys.org/news/2020-12-forensic-chemist-laser-technique-dist...

 Kangaroos really can 'talk' to us, study finds

Kangaroos can intentionally communicate with humans, research reveals

Animals that have never been domesticated, such as kangaroos, can intentionally communicate with humans, challenging the notion that this behavior is usually restricted to domesticated animals like dogs, horses or goats, a new study has found.

The research which involved kangaroos, marsupials that were never domesticated, at three locations across Australia, revealed that kangaroos gazed at a human when trying to access food which had been put in a closed box. The kangaroos used gazes to communicate with the human instead of attempting to open the box themselves, a behaviour that is usually expected for domesticated animals.

1. Alan G. McElligott, Kristine H. O'Keeffe, Alexandra C. Green. Kangaroos display gazing and gaze alternations during an unsolvable problem task. Biology Letters, 2020; 16 (12): 20200607 DOI: 10.1098/rsbl.2020.0607

https://www.sciencedaily.com/releases/2020/12/201217135258.htm

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https://theconversation.com/coronavirus-new-variant-genomics-resear...

Coronavirus new variant – genomics researcher answers key questions

Colorful, magnetic Janus balls could help foil counterfeiters

Counterfeiters who sell knockoffs of popular shoes, handbags and other items are becoming increasingly sophisticated, forcing manufacturers to find new technologies to stay one step ahead. Now, researchers reporting in ACS Nano have developed tiny Janus balls that show their colored side under a magnetic field. These microparticles could be useful in inks for anti-counterfeiting tags, which could be verified with an ordinary magnet, the researchers say. 

Janus balls are microspheres that have two sides with distinct properties. Researchers wanted to make Janus balls out of two unmixable resins: one that contained magnetic nanoparticles, and another that contained silica particles. The magnetic side of the ball would also contain carbon black, causing that hemisphere to appear dark, whereas the silica particles on the other side of the ball would self-assemble into a crystalline lattice, producing structural colors. The result would be tiny balls that normally have their black sides facing up, except when a magnetic field causes them to flip to their colorful sides.

To make Janus balls, the researchers used a microfluidic device to unite drops of the two resins, with a surfactant added to stabilize the joined drops into a spherical shape. Because the silica-containing colored side of the drops was heavier than the black magnetic side, the force of gravity caused the black side to spontaneously face upward, like a roly-poly toy, when the balls were placed in water. Then, the researchers permanently aligned the magnetic nanoparticles in the balls in the same direction. By applying a magnetic field in the opposite direction, they could flip the balls to their colored sides. The researchers made red and green Janus balls by using different sizes of silica particles, with their magnetic nanoparticles aligned in opposite directions. By changing the direction of the applied magnetic field, they could change the colors of 3D-printed chameleon and butterfly shapes. Using different colors and orientations of Janus balls in inks could produce sophisticated, user-interactive anti-counterfeiting tags, the researchers say.

https://www.acs.org/content/acs/en/pressroom/presspacs/2020/acs-pre...

Quantum Experiment Reveals Particles Can Form Collectives Out of Almost Nothing

How many particles do you need before individual atoms start behaving collectively? According to new research, the number is incredibly low. As few as six atoms will start transitioning into a macroscopic system, under the right conditions.

Using a specially designed ultra-cold laser trap, physicists observed the quantum precursor of the transition from a normal to a superfluid phase – offering a way to study the emergence of collective atomic behaviour and the limits of macroscopic systems.

Many-body physics is the field that seeks to describe and understand the collective behaviour of large numbers of particles: a bucket of water, for example, or a canister of gas. We can describe these substances in terms of their density, or their temperature – the way the substance is acting as a whole.

These are called macroscopic or many-body systems, and we can't understand them by just studying the behaviour of individual atoms or molecules. Rather, their behaviour emerges from the interactions between particles that individually do not have the same properties of the system as a whole.

Some examples of macroscopic behaviours that can't be described microscopically include collective excitations, such as the phonons that oscillate atoms in a crystal lattice. Phase transitions are another example – when a substance transitions from one phase to another – such as when ice melts into liquid, for example, or when liquid evaporates into a gas.

https://www.nature.com/articles/s41586-020-2936-y

https://www.sciencealert.com/quantum-simulator-reveals-that-phase-t...

 Here we observe the few-body precursor of a quantum phase transition from a normal to a superfluid phase. The transition is signalled by the softening of the mode associated with amplitude vibrations of the order parameter, usually referred to as a Higgs mode⁷. We achieve fine control over ultracold fermions confined to two-dimensional harmonic potentials and prepare closed-shell configurations of 2, 6 and 12 fermionic atoms in the ground state with high fidelity. 

Fast walking in narrow corridors can increase COVID-19 transmission risk

Computational simulations have been used to accurately predict airflow and droplet dispersal patterns in situations where COVID-19 might be spread. In the journal Physics of Fluids, results show the importance of the shape of the space in modeling how virus-laden droplets move through the air.

The simulations are used to determine flow patterns behind a walking individual in spaces of different shape. The results reveal a higher transmission risk for children in some instances, such as behind quickly moving people in a long narrow hallway.

Previous investigations using this simulation technique have helped scientists understand the influence of objects, like glass barriers, windows, air conditioners, and toilets, on airflow patterns and virus spread. The previous simulations have usually assumed a large, open indoor space but have not considered the effect of nearby walls, like those that might exist in a narrow corridor.

If a person walking in a corridor coughs, their breath expels droplets that travel around and behind their body, forming a wake in the way a boat forms a wake in water as it travels. The investigation revealed the existence of a "re-circulation bubble" directly behind the person's torso and a long wake streaming out behind them at approximately waist height.

The flow patterns found are strongly related to the shape of the human body. At 2 meters downstream, the wake is almost negligible at mouth height and leg height but is still visible at waist height. 

Once the airflow patterns were determined, the investigation modeled the dispersal of a cloud of droplets expelled from the simulated person's mouth. The shape of the space surrounding the moving person is particularly critical for this part of the calculation.

Two types of dispersal modes were found. In one mode, the cloud of droplets detaches from the moving person and floats far behind that individual, creating a floating bubble of virus-laden droplets. In the other mode, the cloud is attached to the person's back, trailing behind them like a tail as they move through the space.

For the detached mode, the droplet concentration is much higher than for the attached mode, five seconds after a cough. This poses a great challenge in determining a safe social distance in places like a very narrow corridor, where a person may inhale viral droplets even if the patient is far in front of him or her.

The danger is particularly great for children, since in both modes, the cloud of droplets hovers at a distance above the ground that is about half the height of the infected person—in other words, at mouth level for children.

"Effects of space sizes on the dispersion of cough-generated droplets from a walking person," Physics of Fluids (2020). aip.scitation.org/doi/10.1063/5.0034874

https://phys.org/news/2020-12-fast-narrow-corridors-covid-transmiss...

AI-powered microscope could check cancer margins in minutes

When surgeons remove cancer, one of the first questions is, “Did they get it all?” Researchers from Rice University and the University of Texas MD Anderson Cancer Center have created a new microscope that can quickly and inexpensively image large tissue sections, potentially during surgery, to find the answer. The microscope can rapidly image relatively thick pieces of tissue with cellular resolution, and could allow surgeons to inspect the margins of tumors within minutes of their removal. It was created by engineers and applied physicists at Rice and is described in a study published this week in the Proceedings of the National Academy of Sciences.

http://news.rice.edu/2020/12/17/ai-po...

Evolution of a killer: How African Salmonella made the leap from gut to bloodstream

Scientists have exploited the combined power of genomics and epidemiology to understand how a type of Salmonella bacteria evolved to kill hundreds of thousands of immunocompromised people.

Bloodstream infections caused by a drug-resistant type of Salmonella Typhimurium called ST313 are a major public health concern in Africa, where the disease is endemic and causes ~50,000 deaths each year. What was missing was an understanding of the timing of the major evolutionary events that equipped African Salmonella to cause bloodstream infections in humans.

A team of researchers  sampled two comprehensive collections of Salmonella isolates from African patients with bloodstream infections, spanning 1966 to 2018, to piece together the evolutionary journey of the Salmonella over 50 years of human infections in Africa, including the discovery of a new lineage of antibiotic-susceptible ST313.

In the study, scientists sequenced the genomes of 680 Salmonella isolates, from archives kept by the Malawi Liverpool Wellcome Trust (MLW) clinical research programme and the Institute Pasteur, and used them to uncover the timeline of crucial genetic events responsible for the infection of immunocompromised humans by S. Typhimurium ST313. Mutations that influenced gene function during the evolution of ST313 were identified for the first time.

The team also discovered a new antibiotic-susceptible lineage of ST313 that emerged in Malawi in 2016 and is closely related to Salmonella variants that cause stomach infections in the United Kingdom and Brazil. The researchers speculate that changes in antibiotic usage in Malawi between 2002 and 2015 could have created a window of opportunity for the emergence of this new antibiotic-susceptible ST313 lineage.

Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa, Nature Microbiology (2020). DOI: 10.1038/s41564-020-00836-1 , www.nature.com/articles/s41564-020-00836-1

https://phys.org/news/2020-12-evolution-killer-african-salmonella-g...

When T-cells of our immune system become active, tiny traction forc...

When T-cells of our immune system become active, tiny traction forces at the molecular level play an important role. They have now been studied at TU Wien.

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Brazilian forests found to be transitioning from carbon sinks to ca...

A team of researchers affiliated with several institutions in Brazil has found that some non-Amazonian forests in Brazil have already begun to transition from carbon sinks to carbon sources. In their paper published in the journal Science Advances, the group describes their 33-year study of deciduous, semi-deciduous and evergreen forests in Brazil's state of Minas Gerais.

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Current food production systems could mean far-reaching habitat loss

The global food system could drive rapid and widespread biodiversity loss if not changed, new research has found.

The findings show that the global food system will need to be transformed to prevent habitat loss across the world. It shows that what we eat and how it is produced will need to change rapidly and dramatically to prevent widespread and severe biodiversity losses.

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The study estimated how food systems would affect biodiversity at a finer spatial scale than previous research (2.25 km²), making the results more relevant to conservation action by highlighting exactly which species and landscapes are likely to be threatened.

It did so by linking projections of how much agricultural land each country will need with a new model that estimates where agricultural expansion and abandonment are most likely to occur.

Proactive conservation to prevent habitat losses to agricultural expansion, Nature Sustainability (2020). DOI: 10.1038/s41893-020-00656-5 , www.nature.com/articles/s41893-020-00656-5

https://phys.org/news/2020-12-current-food-production-far-reaching-...

Cancer risk from obesity differs for men and women

 large study, published in BMC Medicine, included over 100,000* people. They found that a higher BMI (body mass index; a measure of total fat) is more dangerous for men, whereas a higher waist-to-hip ratio (your waist circumference divided by your hip circumference; a measure of abdominal fat) is more dangerous for women. To discover this, they used an approach, called Mendelian randomisation, that uses genetic information as a proxy measure for weight to investigate the effect of different body fat measures on colorectal cancer risk in men and women. An increase in BMI of about five kg/m2 raised the risk of colorectal cancer by 23 per cent for men, but only nine per cent for women. Whereas an equivalent increase in waist-to-hip ratio raised the risk for women by 25 per cent, this was only five per cent for men. 

http://www.bristol.ac.uk/news/2020/december/obesity-cancer.html

https://researchnews.cc/news/4229/Cancer-risk-from-obesity-differs-...

Gravity Assist: The Bright Spot of the Asteroid Belt

Researchers to resuscitate eyes, speed up clinical research for vision impairment

Researchers to resuscitate eyes, speed up clinical research for vision impairment

Researchers are developing a new method to bring eyes back to life from deceased body donors for clinical research purposes.

They are creating a device that resuscitates eyes from the dead.Vision impairment affects over 250 million people worldwide, with thirty-six million people being blind. Retinal degeneration is often incurable, and ageing populations worldwide are major social and economic challenges.

The device, codenamed ECaBox, will be a transparent, cubic box that mimics conditions in the living human eye, maintaining the eye’s temperature and pH levels while avoiding blood clots and removing metabolic waste and toxins. Inside the ECaBox will be donor human eyeballs. The immediate goal is to test novel stem cell therapies without fear of risking patient harm on this platform.

Artificial blood will also be developed to provide cells with oxygen and nutrients, kick-starting the activity of nerve cells and restoring total eye function. Artificial vitreous humour will maintain the eye’s ocular pressure.

The health of the eyeball will be continuously monitored to confirm retinal function and regeneration. Beyond this scope, this technology can be extended to keep donor eyes intact for transplantation purposes, extending the current 48-hour window limit.

For many patients whose hope to restore their vision rests on emerging therapeutics, this research will mean a quicker and safer development cycle that will lead to the treatments becoming available sooner

Current technological limitations mean that eyes can only be kept at 4ºC for a period of 48 hours before irreversible degradation. This greatly limits their use for experiments, particularly to test the effectiveness of new drugs and treatments.

While advances in human organoids, growing tissues in a petri dish, are successfully mimicking the function of the eye, they fail to encapsulate the eye’s physiological complexity, such as its immune, vasculature, and metabolism systems.

There are a huge number of potential new treatments and therapies for eye damage and vision loss, but the eyewatering cost of running a clinical trial can mean they never reach the market.”

This new method can greatly improve the preclinical validation steps for these treatments, supporting the screening of a larger number of candidates and helping promising drugs escape the ‘valley of death’ imposed by cost-benefit analyses in the pharmaceutical industry.

https://www.kcl.ac.uk/news/researchers-to-resuscitate-eyes-speed-up...

https://researchnews.cc/news/4226/Researchers-to-resuscitate-eyes--...

Octopuses punch fishes during collaborative interspecific hunting events

Octopuses Observed Punching Fish, Perhaps Out of Spite, Scientists Say

In new proof that 2020 has been a crappy year basically everywhere, scientists have captured video evidence of octopuses randomly punching at fish, possibly for no reason other than being spiteful.

While this remarkable, rather nasty-sounding behaviour might seem like it comes from a place of direct conflict between different animal species, that's not the whole story, researchers say.

In fact, this antisocial fish-punching phenomenon – which scientists term "active displacement" of fish – occurs in the midst of collaborative hunting efforts, in which octopuses and fish team up to chase and trap prey together.

https://twitter.com/OctoEduardo/status/1340076579108646913

https://twitter.com/ESAEcology/status/1341125791359373313?s=20

https://esajournals.onlinelibrary.wiley.com/doi/10.1002/ecy.3266

Researchers find hydrogen-supported life beneath glaciers

Using years of data collected from ice-covered habitats all over the world, a research team has discovered new insights into the processes that support microbial life underneath ice sheets and glaciers, and the role those organisms play in perpetuating life through ice ages and, perhaps, in seemingly inhospitable environments on other planets.

The work examines the ways water and microbes interact with the bedrock beneath glaciers, using samples of sediment taken from glacial sites in Canada and Iceland. 

The researchers found organisms in these systems that were supported by hydrogen gas. 

A team of researchers later discovered that through a series of physical and chemical processes, hydrogen gas is produced as the silica-rich bedrock underneath glaciers is ground into tiny mineral particles by the weight of the ice on top of it. When those mineral particles combine with glacial meltwater, they let off hydrogen.

What became even more fascinating was that microbial communities under the glaciers could combine that hydrogen gas with carbon dioxide to generate more organic matter, called biomass, through a process called chemosynthesis. Chemosynthesis is similar to how plants generate biomass from carbon dioxide through photosynthesis, although chemosynthesis does not require sunlight.

As they use hydrogen  gas to generate energy the microbes also pull CO2out of the air to create biomass, replicate and grow. That ability to "fix" carbon is a critical climate regulation process, another similarity to photosynthesis in plants.

The newfound knowledge that self-sustaining microbial communities can flourish in icy environments through the generation of hydrogen gas is a critical step toward identifying potentially habitable environments on other planets.

Lithogenic hydrogen supports microbial primary production in subglacial and proglacial environments PNAS; doi.org/10.1073/pnas.2007051117

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It was also found that not only was it possible to track the communities' growth in the lab environment but also that the type of bedrock underlying a glacier influenced how much hydrogen gas was produced, which in turn led to the presence of microbial communities that were better adapted to metabolizing hydrogen.

https://phys.org/news/2020-12-hydrogen-supported-life-beneath-glaci...

Regulatory RNAs promote breast cancer metastasis

Scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of metastatic tumours with a molecule designed to target that RNA and trigger its destruction. The same strategy, they say, could be used to develop a new breast cancer treatment for patients.

They  identified dozens of RNA molecules that were more prevalent in breast cancer cells than in noncancerous cells of the same type. All were long, non-coding RNAs (lncRNAs)—RNA molecules that do not encode proteins and are thought to play various regulatory roles inside cells. The current study investigated how one of these, Mammary Tumor-Associated RNA 25 (MaTAR 25), impacted breast cancer cells' behavior in mice.

Experiments  indicate the molecule contributes to cancer's progression in several ways—revving up cells' growth as well as their ability to migrate and invade tissue. These effects may be due to changes in the activity of the tensin1 gene, which the team found is one of MaTAR 25's targets. Tensin1 helps connect a cell's internal cytoskeleton to the external matrix that surrounds it and is therefore positioned to influence a cell's movement as well as its growth-regulating pathways.

Nature Communications (2020). DOI: 10.1038/s41467-020-20207-y

https://medicalxpress.com/news/2020-12-regulatory-rnas-breast-cance...

Scientists discover mutations associated with early onset dementia

Scientists recently announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer's disease.

Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterized by mutations in a gene called Colony stimulating factor-1 receptor (CSF1R). The condition manifests initially with psychiatric and behavioral changes in patients followed by a rapid progression of dementia in the third or fourth decade of life. While the condition is very rare, for affected families it can represent a devastating diagnosis.

As the condition involves the degeneration of white matter in the brain, scientists previously thought that immune cells within the brain termed microglia were the primary culprits in driving pathology observed in this condition.

However, the Trinity team, working with patient samples as well as pre-clinical models, were able to show that dysfunctional circulating white blood cells were the key driver of neurodegeneration.

These findings have shed light on a novel mechanism of neurodegeneration that may ultimately teach us more about common forms of dementia. Importantly, the work has identified that a disruption in CSF1R function in patients, as well as in pre-clinical models, induces damage to the so-called blood-brain barrier (BBB). This damage can subsequently change the integrity of capillaries in the brain, causing them to leak and spark the deterioration of the brain. Intriguingly, dysfunctional white blood cells seem to be the main driver of this BBB breakdown.

EMBO Molecular Medicine (2020). DOI: 10.15252/emmm.202012889

Researchers discover how the brain 're-wires' after disease

https://medicalxpress.com/news/2020-12-scientists-mutations-early-o...

Detecting COVID-19 antibodies in 10 seconds

Researchers at Carnegie Mellon University report findings on an advanced nanomaterial-based biosensing platform that detects, within seconds, antibodies specific to SARS-CoV-2, the virus responsible for the COVID-19 pandemic. In addition to testing, the platform will help to quantify patient immunological response to the new vaccines with precision.

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Visible hydrogels for rapid hemorrhage control and monitoring

There are many different events which may lead to excessive and uncontrolled bleeding within the body. This can occur as a result of inflammation and ulcerations, abnormalities in the blood vessels or trauma-related injuries. Individuals with predisposing conditions, such as cardiac patients, are at particular risk of internal bleeding due to the anticoagulants they are often prescribed as a preventive measure. They are also prone to gastrointestinal bleeds, affecting 40% of patients who are on cardiac assistance devices. In addition to the need for an effective treatment for these conditions, there are also indications for controlling the blood flow that contribute to aneurysms and tumor cell vascularization.

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Masks not enough to stop COVID-19's spread without distancing: study

Simply wearing a mask may not be enough to prevent the spread of COVID-19 without social distancing.

In Physics of Fluids, researchers tested how five different types of mask materials impacted the spread of droplets that carry the coronavirus when we cough or sneeze.

Every material tested dramatically reduced the number of droplets that were spread. But at distances of less than 6 feet, enough droplets to potentially cause illness still made it through several of the materials.

"A mask definitely helps, but if the people are very close to each other, there is still a chance of spreading or contracting the virus".

Without a face mask, it is almost certain that many foreign droplets will transfer to the susceptible person. "Wearing a mask will offer substantial, but not complete, protection to a susceptible person by decreasing the number of foreign airborne sneeze and cough droplets that would otherwise enter the person without the mask. Consideration must be given to minimize or avoid close face-to-face or frontal human interactions, if possible."

The study also did not account for leakage from masks, whether worn properly or improperly, which can add to the number of droplets that make their way into the air.

"Can face masks offer protection from airborne sneeze and cough droplets in close-up, face-to-face human interactions? A quantitative study," Physics of Fluids, aip.scitation.org/doi/10.1063/5.0035072

https://phys.org/news/2020-12-masks-covid-distancing.html?utm_sourc...

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Chemists describe a new form of ice

Scientists have described the structure and properties of a novel hydrogen clathrate hydrate that forms at room temperature and relatively low pressure. Hydrogen hydrates are a potential solution for storage and transportation of hydrogen, the most environmentally friendly fuel.
Ice is a highly complex substance that has multiple polymorphic modifications that keep growing in number as scientists make new discoveries. The physical properties of ice vary greatly, too: for example, hydrogen bonds become symmetric at high pressures, making it impossible to distinguish a single water molecule, whereas low pressures cause proton disorder, placing water molecules in many possible spatial orientations within the crystal structure. Ice around us, including snowflakes, is always proton-disordered. Ice can incorporate xenon, chlorine, carbon dioxide or methane molecules and form gas hydrates which often have a different structure from pure ice. The vast bulk of Earth's natural gas exists in the form of gas hydrates.
In their new study, the chemists focused on hydrogen hydrates. Gas hydrates hold great interest both for theoretical research and practical applications, such as hydrogen storage. If stored in its natural form, hydrogen poses an explosion hazard, whereas density is way too low even in compressed hydrogen. That is why scientists are looking for cost-effective hydrogen storage solutions.
This is not the first time we turn to hydrogen hydrates. In our previous research, we predicted a novel hydrogen hydrate with 2 hydrogen molecules per water molecule. Unfortunately, this exceptional hydrate can only exist at pressures above 380,000 atmospheres, which is easy to achieve in the lab, but is hardly usable in practical applications. The new paper describes hydrates that contain less hydrogen but can exist at much lower pressures.

Yu Wang et al. Novel Hydrogen Clathrate Hydrate, Physical Review Letters (2020). DOI: 10.1103/PhysRevLett.125.255702

https://phys.org/news/2020-12-chemists-ice.html?utm_source=nwletter...

Scientists invent glue activated by magnetic field

Scientists from Nanyang Technological University, Singapore (NTU Singapore), have developed a new way to cure adhesives using a magnetic field.

Conventional adhesives like epoxy which are used to bond plastic, ceramics and wood are typically designed to cure using moisture, heat or light. They often require specific curing temperatures, ranging from room temperature up to 80 degrees Celsius.

The curing process is necessary to cross-link and bond the glue with the two secured surfaces as the glue crystallizes and hardens to achieve its final strength.

NTU's new 'magnetocuring' glue can cure by passing it through a magnetic field. This is very useful in certain environmental conditions where current adhesives do not work well. Also, when the adhesive is sandwiched between insulating material like rubber or wood, traditional activators like heat, light and air cannot easily reach the adhesive.

The new adhesive is made of two main components—a commercially available epoxy that is cured through heat, and oxide nanoparticles made from a chemical combination including manganese, zinc and iron (MnxZn_1-xFe₂O₄).

These nanoparticles are designed to heat up when electromagnetic energy is passed through them, activating the curing process. The maximum temperature and rate of heating can be controlled by these special nanoparticles, eliminating overheating and hotspot formation.

Richa Chaudhary et al, Magnetocuring of temperature failsafe epoxy adhesives, Applied Materials Today (2020). DOI: 10.1016/j.apmt.2020.100824

https://phys.org/news/2020-12-scientists-magnetic-field.html?utm_so...

How Does SpaceX Build Their Rockets

We Just Got Closer to Smartphone Screens That Can 'Heal' Their Own Cracks

Dropping your smartphone often means living with a cracked screen until your next upgrade, or footing an expensive repair bill – but researchers have been busy bringing self-healing display technology closer to a practical reality.

A team from the Korea Institute of Science and Technology (KIST) has developed a self-healing electronic material that can repair its own cracks and other physical damage, and it has one secret ingredient: linseed oil.

Linseed oil is made from flax plant seeds, and these same seeds were adapted by the researchers in a similar way in order to add them to colourless polyimide (CPI) – an alternative to glass that's already finding uses in folding smartphone screens.

That added oil ingredient is able to seep into cracks made when the CPI is fractured, and – if the scientists are able to get it working reliably at scale, could mean screens that are able to bandage their own wounds after a smash.

Researchers were able to develop a self-healing, colourless polyimide that can radically solve the physical properties and lifespan of damaged polymer materials.

The linseed oil that aids this self-healing was first loaded into microcapsules which were then mixed with a silicone material. That material was then used as a coating on top of CPI in the experiments the researchers ran.

The way that the material is designed means that breaks in the CPI also lead to breaks in the microcapsules, releasing the stored oil to repair the damage. When the oil substance hits the air, it hardens, and the material is almost as good as new.

Even better, this all works at room temperature and without the need for external pressure, unlike similar self-healing materials that have been explored before. Higher temperatures, greater humidity and ultraviolet light can speed up the healing process, the researchers report.

https://www.sciencedirect.com/science/article/abs/pii/S135983682033...

https://www.sciencealert.com/we-re-another-step-towards-smartphone-...

Research team reports new class of antibiotics active against a wide range of bacteria

 Scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR).

Existing antibiotics target essential bacterial functions, including nucleic acid and protein synthesis, building of the cell membrane, and metabolic pathways. However, bacteria can acquire drug resistance by mutating the bacterial target the antibiotic is directed against, inactivating the drugs or pumping them out.

However, harnessing the immune system to simultaneously attack bacteria on two different fronts makes it hard for them to develop resistance. 

So researchers focused on a metabolic pathway that is essential for most bacteria but absent in humans, making it an ideal target for antibiotic development. This pathway, called methyl-D-erythritol phosphate (MEP) or non-mevalonate pathway, is responsible for biosynthesis of isoprenoids—molecules required for cell survival in most pathogenic bacteria. The lab targeted the IspH enzyme, an essential enzyme in isoprenoid biosynthesis, as a way to block this pathway and kill the microbes. Given the broad presence of IspH in the bacterial world, this approach may target a wide range of bacteria.

Researchers used computer modeling to screen several million commercially available compounds for their ability to bind with the enzyme, and selected the most potent ones that inhibited IspH function as starting points for drug discovery.

The team demonstrated that the IspH inhibitors stimulated the immune system with more potent bacterial killing activity and specificity than current best-in-class antibiotics when tested in vitro on clinical isolates of antibiotic-resistant bacteria, including a wide range of pathogenic gram negative and gram positive bacteria. In preclinical models of gram negative bacterial infection, the bactericidal effects of the IspH inhibitors outperformed traditional pan antibiotics. All compounds tested were shown to be nontoxic to human cells.

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance, Nature (2020). DOI: 10.1038/s41586-020-03074-x , www.nature.com/articles/s41586-020-03074-x

https://medicalxpress.com/news/2020-12-team-class-antibiotics-wide-...

** Highest levels of microplastics found in molluscs, new study says

Mussels, oysters and scallops have the highest levels of microplastic contamination among seafood, a new study reveals.

The research looked at more than 50 studies between 2014 and 2020 to investigate the levels of microplastic contamination globally in fish and shellfish.

Scientists are still trying to understand the health implications for humans consuming fish and shellfish contaminated with these tiny particles of waste plastic, which finds its ways into waterways and oceans through waste mismanagement.

The paper, "Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis" is published in Environmental Health Perspectives.

Plastic is blowing in the wind

As the plastic in our oceans breaks up into smaller and smaller bits without breaking down chemically, the resulting microplastics are becoming a serious ecological problem. A new study at the Weizmann Institute of Science reveals a troubling aspect of microplastics—defined as particles smaller than 5 mm across. They are swept up into the atmosphere and carried on the wind to far-flung parts of the ocean, including those that appear to be clear. Analysis reveals that such minuscule fragments can stay airborne for hours or days, spreading the potential to harm the marine environment and, by climbing up the food chain, to affect human health.

A handful of studies have found microplastics in the atmosphere right above the water near shorelines.

 Trainic, M., Flores, J.M., Pinkas, I. et al. Airborne microplastic particles detected in the remote marine atmosphere. Commun Earth Environ 1, 64 (2020). doi.org/10.1038/s43247-020-00061-

https://phys.org/news/2020-12-plastic.html?utm_source=nwletter&...

Play sport or watch it? You’re probably emitting an astonishing amount of CO₂!

Few people would stop to consider if their sporting activities damage the environment. But research shows people in some places use a huge chunk of their “personal carbon budget” driving to and from sport events each year – either to watch or participate, or to transport children. Travel for soccer, swimming, cricket, football, basketball and tennis featured most commonly, followed by gym, jogging, walking and golf. The analysis assumed walking and biking to an activity emits no greenhouse gases. Public transport accounts for less than 0.02 kilograms per kilometre (kg/km). A combustion engine car produces an average 0.29 kg/km. Such sport-related travel behaviour may be due to various factors, including: a long distance to sporting facilities sports facilities not served by public transport and not connected to safe cycle paths lifestyle choice and convenience persistent habits due to lack of awareness and role models. So now it’s time sports organisations turned their collective minds to better understanding the costs and damage caused by CO₂ emissions – and finding solutions.

https://theconversation.com/drive-to-football-take-your-kids-to-the...

Four ways microbial fuel cells might revolutionize electricity production in the future

The world population is estimated to reach 9.5 billion by 2050. Given that most of our current energy is generated from fossil fuels, this creates significant challenges when it comes to providing enough sustainable electricity while mitigating climate change.

One idea that has gained traction over recent years is generating electricity using bacteria in devices called microbial fuel cells (MFCs). These fuel cells rely on the ability of certain naturally occurring microorganisms that have the ability to "breathe" metals, exchanging electrons to create electricity. This process can be fuelled using substances called substrates, which include organic materials found in wastewater.

At the moment microbial fuel cells are able to generate electricity to power small devices such as calculators, small fans and LEDs.

Making jet fuel out of carbon dioxide

A team of researchers affiliated with several institutions in the U.K. and one in Saudi Arabia has developed a way to produce jet fuel using carbon dioxide as a main ingredient. In their paper published in the journal Nature Communications, the group describes their process and its efficiency.

The researchers used a process called the organic combustion method to convert carbon dioxide in the air into jet fuel and other products. It involved using an iron catalyst (with added potassium and manganese) along with hydrogen, citric acid and carbon dioxide heated to 350 degrees C. The process forced the carbon atoms apart from the oxygen atoms in CO₂ molecules, which then bonded with hydrogen atoms, producing the kind of hydrocarbon molecules that comprise liquid jet fuel. The process also resulted in the creation of water molecules and other products.

Testing showed that over 20 hours, the process converted 38% of the carbon dioxide in a pressurized chamber into jet fuel and other products. The jet fuel made up 48% of the produced products—the others were water, propylene and ethylene. The researchers also note that using this fuel in aircraft would be carbon-neutral because burning it would release the same amount of carbon dioxide that was used to make it.

The researchers also claim their process is less expensive than other methods used to produce fuel for airplanes, such as those that convert hydrogen and water into fuel—primarily because it uses less electricity. They also point out that conversion systems could be installed in plants that currently emit a lot of carbon dioxide, such as coal fired power plants.

Benzhen Yao et al. Transforming carbon dioxide into jet fuel using an organic combustion-synthesized Fe-Mn-K catalyst, Nature Communications (2020). DOI: 10.1038/s41467-020-20214-z

https://phys.org/news/2020-12-jet-fuel-carbon-dioxide.html?utm_sour...

Tiny Medical Devices with Shape Memory Polymers

We Now Have Shocking Evidence That Microplastic Particles Can Enter The Placenta

First evidence of microplastics in human placenta

The 21st century human is born into a world coated in a fine dust of petrochemical waste.

Our personal connection with microscopic fragments of plastic might even stretch back to the womb, with traces of the material recently found in the human placenta.

Placentas collected in a plastic-free environment from six mothers were sectioned, dissolved, and filtered to reveal 12 small pieces of coloured plastic, all somewhere between 5 and 10 micrometres in size. All came from just four of the placentas.

While four of the fragments were found in tissues belonging on the mother's side of the placenta, five were identified closer to the developing foetus. The last three were found embedded in the fine membrane that forms a wall around the amniotic fluid.

It might not seem like a huge number of particles, especially given their size. But it's important to remember the amount of tissue removed for analysis represents just a few percent of the organ's mass, hinting at far more microplastic fragments in total.

The placenta is an insanely complex aggregation of tissues shaped by millions of years of evolution to isolate an emerging life at the most crucial stage of its development.

Its function involves filtering pathogens and other potentially hazardous materials from the mother's bloodstream, while permitting various nutrients, antibodies, and oxygen to pass.

More than just a protective wall of meat, the organ also comprises diverse and dynamic systems of cells managed by a delicate balance of hormones and carefully timed biochemical reactions.

Whether any of the intrusive particles pose some kind of health risk to an unborn baby isn't yet clear. We'll need a lot more research before we can conclusively draw any firm links.

Since many plastic additives like the endocrine disruptor bisphenol A are known to interfere with our body's functions, their presence alone in such a sensitive part of the human body is deeply concerning.

"Due to the crucial role of placenta in supporting the foetus's development and in acting as an interface with the external environment, the presence of potentially harmful plastic particles is a matter of great concern," the team writes in their report.

https://www.sciencedirect.com/science/article/pii/S0160412020322297

https://www.sciencealert.com/we-now-have-shocking-evidence-that-mic...

Scientists pioneer new method of measuring electricity in cells

Electricity is a key ingredient in living bodies. We know that voltage differences are important in biological systems; they drive the beating of the heart and allow neurons to communicate with one another. But for decades, it wasn't possible to measure voltage differences between organelles—the membrane-wrapped structures inside the cell—and the rest of the cell.

A pioneering technology now developed  allows researchers to peer into cells to see how many different organelles use voltages to carry out functions.

Tiny sensors were built to travel inside cells and report back on what's happening, so that researchers can understand how cells work—and how they break down in disease or disorders. Previously, they have built such machines to study neurons and lysosomes, among others.

In this case, they decided to use the technique to investigate the electric activities of the organelles inside live cells.

In the membranes of neurons, there are proteins called ion channels which act as gateways for charged ions to enter and exit the cell. These channels are essential for neurons to communicate. Previous research had shown that organelles have similar ion channels, but we weren't sure what roles they played.

The researchers' new tool, called Voltair, makes it possible to explore this question further. It works as a voltmeter measuring the voltage difference of two different areas inside a cell. Voltair is constructed out of DNA, which means it can go directly into the cell and access deeper structures.

In their initial studies, the researchers looked for membrane potentials—a difference in voltage inside an organelle versus outside. They found evidence for such potentials in several organelles, such as trans-Golgi networks and recycling endosomes, that were previously thought not to have membrane potentials at all.

The membrane potential in organelles could play a larger role—maybe it helps organelles communicate.

Anand Saminathan et al. A DNA-based voltmeter for organelles, Nature Nanotechnology (2020). DOI: 10.1038/s41565-020-00784-1

https://phys.org/news/2020-12-scientists-method-electricity-cells.h...

Can't draw a mental picture? Aphantasia causes blind spots in the mind's eye

If you were asked to draw a picture of your grandparents' living room from memory, could you do it? For most people, certain details are easy to visualize: "There's a piano in the corner, a palm by the window and two seashells on the coffee table."

But for others, such a task would be almost impossible. These individuals have a rare condition called aphantasia, which prevents them from easily recreating images in their mind's eye—in fact, the phrase "mind's eye" may be meaningless to them.

"Some individuals with aphantasia have reported that they don't understand what it means to 'count sheep' before going to bed." They thought it was merely an expression, and had never realized until adulthood that other people could actually visualize sheep without seeing them.

The differences in the memory experiment were striking: Individuals with typical imagery usually drew the most salient objects in the room with a moderate amount of detail, like color and key design elements (a green carpet, rather than a rectangle).

Individuals with aphantasia had a harder time—they could place a few objects in the room, but their drawings were often simpler, and relied at times on written descriptions. For example, some wrote the word "window" inside an outline of a window rather than drawing the windowpanes.

While people with aphantasia lack visual imagery, they appear to have intact spatial memory, which is distinct from imagery and may be stored differently . People who are congenitally blind, for example, can still describe the layout of a familiar room.

even though people with aphantasia remembered fewer objects overall, they also made fewer mistakes: They didn't create any false memories of objects that hadn't been in any of the rooms, and placed objects in the correct location—but the wrong room—only three times.

"One possible explanation could be that because aphantasics have trouble with this task, they rely on other strategies like verbal-coding of the space. Their verbal representations and other compensatory strategies might actually make them better at avoiding false memories."

Wilma A. Bainbridge et al. Quantifying aphantasia through drawing: Those without visual imagery show deficits in object but not spatial memory, Cortex (2020). DOI: 10.1016/j.cortex.2020.11.014

https://medicalxpress.com/news/2020-12-mental-picture-aphantasia-mi...

**

Study on health effects and citizen resistance during the lockdown

https://medicalxpress.com/news/2020-12-publish-health-effects-citiz...

There’s no magic way to boost your energy. But ‘perineum sunning’ isn’t the answer

Perineum sunning is said to have roots in an ancient Taoist practice, where the perineum, or “Hui Yin”, is regarded as a gateway where energy enters and exits the body.

It’s probably also related to the idea that the sun has healing powers. Many years ago sun exposure was recommended after childbirth, and sunlamps were used in labour wards to ostensibly aid healing. But there was no evidence for this.

Some of the appeal of the trend might also lie in the fact many pale-skinned people like to be tanned.

That said, tanning is not the motivation behind the perineum sunning wellness trend. People who do it say it gives their body an intense dose of vitamin D, and therefore a significant energy boost.

It can also supposedly increase creativity, improve sleep, and even promote a healthy libido, among other reported benefits.

Read more: Your vagina cleans itself: why vagina cleaning fads are unnecessary...

But there’s no evidence to support any of these supposed benefits. Although there have been no scientific studies on perineum sunning to date. 

However, we can’t dismiss the placebo effect. For example, if someone thinks sunning their perineum will improve their libido, it probably will.

The main risk of perineum sunning is sunburn. Sun-exposed skin adapts to exposure to ultraviolet (UV) light by forming melanin, the natural protective pigment in skin that reduces the risk of sunburn. So when you get UV light on a part of your skin that’s not accustomed to sun exposure, you’re much more likely to get burnt.

If you do get sunburnt in this sensitive area, it’s likely to be very sore. You won’t be able to have sex for about a week, and it might sting to urinate.

And of course, UV is a known carcinogen, which is why nowadays we discourage any kind of tanning. Sunburn can increase your risk of skin cancer, and chronic UV exposure can raise skin cancer risk even without causing sunburn.

https://theconversation.com/theres-no-magic-way-to-boost-your-energ...

How could stars help us detect life on other planets?

The Year's Biggest Breakthroughs in Biology

The Year's Biggest Breakthroughs in Physics

Different people will show different views on the best science breakthroughs of the year. We present some of them here.

One such view: The biggest and most important scientific breakthroughs of 2020

https://au.news.yahoo.com/most-important-scientific-breakthroughs-o...

When light and atoms share a common vibe

An especially counter-intuitive feature of quantum mechanics is that a single event can exist in a state of superposition – happening both here and there, or both today and tomorrow.

Such superpositions are hard to create, as they are destroyed if any kind of information about the place and time of the event leaks into the surrounding – and even if nobody actually records this information. But when superpositions do occur, they lead to observations that are very different from that of classical physics, questioning down to our very understanding of space and time.

Scientists demonstrated a state of vibration that exists simultaneously at two different times, and evidence this quantum superposition by measuring the strongest class of quantum correlations between light beams that interact with the vibration.

The researchers used a very short laser-pulse to trigger a specific pattern of vibration inside a diamond crystal. Each pair of neighboring atoms oscillated like two masses linked by a spring, and this oscillation was synchronous across the entire illuminated region. To conserve energy during this process, a light of a new color is emitted, shifted toward the red of the spectrum.

This classical picture, however, is inconsistent with the experiments. Instead, both light and vibration should be described as particles, or quanta: light energy is quantized into discrete photons while vibrational energy is quantized into discrete phonons (named after the ancient Greek “photo = light” and “phono = sound”).

The process described above should therefore be seen as the fission of an incoming photon from the laser into a pair of photon and phonon – akin to nuclear fission of an atom into two smaller pieces.

But it is not the only shortcoming of classical physics. In quantum mechanics, particles can exist in a superposition state, like the famous Schrödinger cat being alive and dead at the same time.

Even more counterintuitive: two particles can become entangled, losing their individuality. The only information that can be collected about them concerns their common correlations. Because both particles are described by a common state (the wavefunction), these correlations are stronger than what is possible in classical physics. It can be demonstrated by performing appropriate measurements on the two particles. If the results violate a classical limit, one can be sure they were entangled.

In the new study, EPFL researchers managed to entangle the photon and the phonon (i.e., light and vibration) produced in the fission of an incoming laser photon inside the crystal. To do so, the scientists designed an experiment in which the photon-phonon pair could be created at two different instants. Classically, it would result in a situation where the pair is created at time t1 with 50% probability, or at a later time t2 with 50% probability.

But here comes the “trick” played by the researchers to generate an entangled state. By a precise arrangement of the experiment, they ensured that not even the faintest trace of the light-vibration pair creation time (t1 vs. t2) was left in the universe. In other words, they erased information about t1 and t2. Quantum mechanics then predicts that the phonon-photon pair becomes entangled, and exists in a superposition of time t1andt2. This prediction was beautifully confirmed by the measurements, which yielded results incompatible with the classical probabilistic theory.

By showing entanglement between light and vibration in a crystal that one could hold in their finger during the experiment, the new study creates a bridge between our daily experience and the fascinating realm of quantum mechanics.

https://researchnews.cc/news/4299/When-light-and-atoms-share-a-comm...

https://actu.epfl.ch/news/when-light-and-atoms-share-a-common-vibe/

When light and atoms share a common vibe- explained below

**

When light and atoms share a common vibe

1. A laser generates a very short pulse of light 2. A fraction of this pulse is sent to a nonlinear device to change its color 3. The two laser pulses overlap on the same path again, creating a “write & read” pair of pulses. 4. Each pair is split into a short and a long path, 5. yielding an “early” and a “late” time slot, overlapping once again 6. Inside the diamond, during the “early” time slot, one photon from the “write” pulse may generate a vibration, while one photon from the “read” pulse converts the vibration back into light. 7. The same sequence may also happen during the “late” slot. But in this experiment, the scientists made sure that only one vibration is excited in total (in both early and late time slots). 8. By overlapping the photons in time again it becomes impossible to discriminate the early vs. late moment of the vibration. The vibration is now in a quantum superposition of early and late time. 9. In the detection apparatus, “write” and “read” photons are separated according to their different colors, and analyzed with single-photon counters to reveal their entanglement. Full article: https://actu.epfl.ch/news/when-light-...

Breaking bad: How shattered chromosomes make cancer cells drug-resi...

Researchers recently described how a phenomenon known as chromothripsis breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth. Chromothripsis is a catastrophic mutational event in a cells history that involves massive rearrangement of its genome, as opposed to a gradual acquisition of rearrangements and mutations over time. Genomic rearrangement is a key characteristic of many cancers, allowing mutated cells to grow or grow faster, unaffected by anti-cancer  therepies.

These rearrangements can occur in a single step. During chromothripsis, a chromosome in a cell is shattered into many pieces, hundreds in some cases, followed by reassembly in a shuffled order. Some pieces get lost while others persist as extra-chromosomal DNA (ecDNA). Some of these ecDNA elements promote cancer cell growth and form minute-sized chromosomes called ‘double minutes.

Research found that up to half of all cancer cells in many types of cancers contain ecDNA carrying cancer-promoting genes. The scientists also identified how chromothripsis drives ecDNA formation after gene amplification inside a chromosome.

Chromothripsis converts intra-chromosomal amplifications (internal) into extra-chromosomal (external) amplifications and that amplified ecDNA can then reintegrate into chromosomal locations in response to DNA damage from chemotherapy or radiotherapy. The new work highlights the role of chromothripsis at all critical stages in the life cycle of amplified DNA in cancer cells, explaining how cancer cells can become more aggressive or drug-resistant.

https://health.ucsd.edu/news/releases/Pages/breaking-bad-how-shatte...

https://researchnews.cc/news/4292/Breaking-bad--How-shattered-chrom...

Putting The History Of Earth Into Perspective

The first endovascular technology that can explore capillaries

 The cardiovascular system is astonishing. It uses the blood that circulates in our veins and arteries to transport oxygen and nutrients to every tissue in the body.

Researchers  have decided to harness hydrokinetic energy (mechanical energy resulting from the motion of liquids) to get to places in the human body without resorting to invasive methods. “Large proportions of the brain remain inaccessible because the existing tools are unwieldy, and exploring the tiny, intricate cerebral vascular system without causing tissue damage is extremely difficult.

Doctors can access patients’ arteries by pushing and rotating guidewires, and later sliding hollow tubes called catheters. However, when arteries begin to narrow, especially in the brain, this advancement technique reveals its limits. Scientists now engineered tethered microscopic devices that could be introduced into capillaries with unprecedented speed and ease. The devices consist of a magnetic tip and an ultraflexible body made of biocompatible polymers. Since no mechanical force is applied directly at the vessel wall, the risk of causing any damage is very low. Moreover, harnessing blood flow could reduce the operation time from several hours to a couple of minutes. Both the release of the device and magnetic steering are under computer control. Furthermore, there is no need for force feedback as the tip of the device does not push against the vessel walls. 

Researchers at EPFL’s School of Engineering tested the device inside artificial microvasculature systems. The next phase will involve tests on animals with state-of-the-art medical imaging systems. Scientists are also hoping to develop other devices with a range of on-board actuators and sensors.

https://actu.epfl.ch/news/the-first-endovascular-technology-that-ca...

https://researchnews.cc/news/4309/The-first-endovascular-technology...

Harnessing blood flow to navigate endovascular microrobots