RNA folding in action

Heard about vampire birds? Watch them drinking blood in this video

In the Galápagos, when there's no food to be found, the sharp-beaked ground finch adapts with a bloodthirsty appetite. Their target: nearby seabirds called boobies

Type 2 diabetes: short-term low-carb diet linked to remission – but...

Latest meta-analysis shows weight loss is the most important factor in achieving remission.

Fake news: bold visual warnings needed to stop people clicking – ne...

Prominent 'danger' signs are needed online to warn people about misinformation.

https://theconversation.com/fake-news-bold-visual-warnings-needed-t...

The honey detectives are closing in on China’s shady syrup swindlers

Honey tests

Honey is not just a single consistent substance. Instead it’s a complex mix of sugars which vary according to the region it comes from, the flowers it is derived from and the time of harvesting. Designing a test that can work across a range of honeys and pick out the adulterated ones is a serious scientific challenge.

Historically regulators have relied on the one internationally accepted test, technically known as AOAC 998.12, but usually called the C4 Sugar test. This exploits the fact that the sugar molecules produced by tropical plants, such as sugarcane and maize, have four carbon atoms (C4), while the nectar and pollen protein collected by bees typically come from plants whose sugars have three carbon atoms (C3).

The test uses this difference to see whether C4 sugars have been added to honey. Fraudsters have, however, long been aware of this test – and how to beat it. They simply found other sources of cheap syrup, such as from rice or sugar beet, whose sugar molecules resemble those in honey – so undermining the test.

Scientists have fought back with other approaches, including liquid chromatography/isotope ratio mass spectrometry (lc/irms) which can detect C3 sugars from rice and sugar beet. But the laboratories warn fraudsters have found ways around this test too, creating syrups which mimic the composition of honey. Chinese traders even advertise on Alibaba that their syrup for blending with honey will pass the C4/C3 sugar tests.

There are other tests, but they all have their limitations. There are tests for enzymes such as beta-fructofuranosidase, which are used in industrial processes to turn sucrose into fructose, but the UK honey industry claims they can produce false positives because they do not properly account for the wide variations in honey profiles around the world.

Another test detects psicose in honey, a rare sugar which is not usually found in honey and is a marker for syrup adulteration. This sugar is however found naturally in a very small number of honeys, including chestnut honey, and is therefore unsuitable for prosecuting suspected fraudsters.

The failure to win the technological arms race means regulators are usually unable to prosecute – even though many scientists believe vast quantities of honey sold in shops are adulterated. No existing tests for honey purity are considered sufficiently robust to prove fraud. Or at least not until now.

Nuclear Magnetic Resonance (NMR) is the technology that could change everything. It works by bathing samples in a powerful magnetic field, causing the atoms to resonate. The resonant frequencies of the nuclei in the atoms are then converted into peaks or spectra on a graph, generating a unique magnetic ‘signature’ for each sample.

In the case of honey, the technique is used to compare the molecular profile of a sample ‘honey’ with the NMR database of genuine honeys to establish authenticity. NMR can identify all the sugars, proteins and other molecules present – including those which should never be in any pure natural honey.

Beekeepers hope NMR will prove a technological lifeline.

https://www.wired.co.uk/article/honey-fraud-detection?utm_source=Na...

New tool removes chemotherapy drugs from water systems

'What goes in, must come out' is a familiar refrain. It is especially pertinent to the challenges facing UBC researchers who are investigating methods to remove chemicals and pharmaceuticals from public water systems.

--

grounded following two fatal crashes.

https://scx1.b-cdn.net/csz/news/tmb/2021/fakenewsbold.jpg" width="60" height="60" alt="" class="CToWUd" />

Fake news: Bold visual warnings needed to stop people clicking – ne... A senior doctor in charge of the NHS anti-disinformation campaign has said that language and cultural barriers could be causing people from ethnic minorities to reject the COVID-19 vaccine. Dr. Harpreet Sood told the BBC it was "a big concern" and officials were working hard to reach different groups "to correct so much fake news."

Your Partner’s Genome May Affect Your Health

A study using data from more than 80,000 couples finds evidence of indirect genetic effects on traits ranging from smoking habits to mental health.

C. Xia et al., “Evidence of horizontal indirect genetic effects in humans,” Nat Hum Behav, doi:10.1038/s41562-020-00991-9, 2020.

https://www.the-scientist.com/news-opinion/your-partners-genome-may...

https://www.the-scientist.com/news-opinion/your-partners-genome-may...

Why cancer cells waste so much energy

study sheds light on the longstanding question of why cancer cells get their energy from fermentation.

In the 1920s, German chemist Otto Warburg discovered that cancer cells don't metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. Now biologists have now found a possible answer to this longstanding question. In a study appearing in Molecular Cell, they showed that this metabolic pathway, known as fermentation, helps cells to regenerate large quantities of a molecule called NAD+, which they need to synthesize DNA and other important molecules. Their findings also account for why other types of rapidly proliferating cells, such as immune cells, switch over to fermentation. This has really been a hundred-year-old paradox that many people have tried to explain in different ways.

Why cancer cells waste so much energy

https://news.mit.edu/2021/cancer-cells-waste-energy-0115

https://researchnews.cc/news/4689/Why-cancer-cells-waste-so-much-en...

Brilliant magnetar eruption in neighboring galaxy could aid search in the Milky Way

Termite mounds inspire energy-efficient buildings

Butterflies create jet propulsion with a clap of their wings

The whimsical, wafting flight of butterflies may not give the impression of top aerodynamic performance, but research published recently suggests their large flexible wings could be perfectly designed to give them a burst of jet propulsion.

Scientists set out to verify a decades-old theory that insects "clap" their wings together, squeezing out the air between with such force that it thrusts them forward.

In their aerodynamic analysis of free-flying butterflies published in the journal Interface, they showed that the clap function does generate a jet of air propulsion. But they also found that the butterflies perform this move "in a far more advanced way than we ever realised"

These findings could have uses for drones that use clapping wing propulsion.

L. C. Johansson et al. Butterflies fly using efficient propulsive clap mechanism owing to flexible wings, Journal of The Royal Society Interface (2021). DOI: 10.1098/rsif.2020.0854

https://phys.org/news/2021-01-butterflies-jet-propulsion-wings.html...

Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease—cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

Researchers are taking a new, targeted approach to myeloma treatment—silencing IRF4, a gene that allows myeloma stem cells and tumour cells to proliferate and survive. Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease.

The team details their successes inhibiting IRF4 with an antisense oligonucleotide, an engineered piece of DNA specifically designed to bind the genetic material coding for IRF4, causing it to degrade. The oligonucleotide—an investigational antisense medicine developed by Ionis and known as ION251—lowered disease burden, reduced myeloma stem cell abundance and increased survival of mice bearing human myeloma, according to preclinical study data.

Cell Stem Cell (2021). www.cell.com/cell-stem-cell/fu … 1934-5909(20)30601-9

https://medicalxpress.com/news/2021-01-dna-therapeutic-cancer-stem-...

Storing information with light

New photo-ferroelectric materials allow storage of information in a non-volatile way using light stimulus. The idea is to create energy efficient memory devices with high performance and versatility to face current challenges. The study has been published in Nature Communications by Josep Fontcuberta and co-workers and opens a path towards further investigations on this phenomenon and to neuromorphic computing applications. 

--

Saturn's tilt caused by its moons

Two scientists from CNRS and Sorbonne University working at the Institute of Celestial Mechanics and Ephemeris Calculation (Paris Observatory—PSL/CNRS) have just shown that the influence of Saturn's satellites can explain the tilt of the rotation axis of the gas giant. Their work, published on 18 January 2021 in the journal Nature Astronomy, also predicts that the tilt will increase even further over the next few billion years.

--

Deep sleep takes out the trash

A new Northwestern University study reaffirms the importance of getting a good night's sleep.

Genesis of blue lightning into the stratosphere detected from ISS

We know that there are many things left to discover, such as blue jets, elves and red sprites. These bizarre-sounding things are very difficult to observe from the surface of the Earth. As a new Nature paper reports, however, the European Atmosphere-Space Interactions Monitor (ASIM) observatory on the International Space Station is helping scientists find answers.

Looking down on Earth's weather from the International Space Station 400 km above, ASIM's enhanced perspective is shedding new light on weather phenomena and their characteristics.

The collection of optical cameras, photometers and an X- and gamma-ray detector was installed on the Space Station in 2018. It is designed to look for electrical discharges originating in stormy weather conditions that extend above thunderstorms into the upper atmosphere.

And now, for the first time for an ESA International Space Station experiment, ASIM's findings have been published in Nature as front-page article. The paper describes a sighting of five intense blue flashes in a cloud top, one generating a 'blue jet' into the stratosphere.

A blue jet is a form of lightning that shoots upwards from thunderstorm clouds. They can reach as far 50 km into the stratosphere and last less than a second. The space storm-hunter measured a blue jet that was kicked off with and intense five 10-microsecond flash in a cloud near the island of Naru in the Pacific Ocean.

The flash also generated equally fantastic-sounding 'elves'. Elves are rapidly expanding rings of optical and UV emissions at the bottom of the ionosphere. Here, electrons, radio waves and the atmosphere interact to form these emissions.

Capturing these phenomena using ASIM's highly sensitive tools is vital for scientists researching weather systems on Earth.

 Observation of the onset of a blue jet into the stratosphere, Nature (2021). DOI: 10.1038/s41586-020-03122-6 , www.nature.com/articles/s41586-020-03122-6

https://phys.org/news/2021-01-genesis-blue-lightning-stratosphere-i...

New antifungal compound from ant farms

Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though the ants share a common ancestor. Now, researchers report in ACS Central Science they have identified the first shared antifungal compound among many of these bacteria across Brazil. The compound could someday have medical applications.

--

When a story is breaking, AI can help consumers identify fake news

Warnings about misinformation are now regularly posted on Twitter, Facebook, and other social media platforms, but not all of these cautions are created equal. New research from Rensselaer Polytechnic Institute shows that artificial intelligence can help form accurate news assessments—but only when a news story is first emerging.

Some COVID-19 mutations may dampen vaccine effectiveness

Scientists are reporting troubling signs that some recent mutations of the virus that causes COVID-19 may modestly curb the effectiveness of two current vaccines, although they stress that the shots still protect against the disease.

Researchers expressed concern Wednesday about the preliminary findings, in large part because they suggest that future mutations could undermine vaccines. The research tested coronaviruses from the United Kingdom, South Africa and Brazil, and was led by Rockefeller University in New York with scientists from the National Institutes of Health and elsewhere.

A different, more limited study out Wednesday gave encouraging news about one vaccine's protection against some of the mutations.

One way vaccines work is to prompt the immune system to make antibodies that block the virus from infecting cells. The Rockefeller researchers got blood samples from 20 people who had received either the Moderna or Pfizer vaccine and tested their antibodies against various virus mutations in the lab.

With some, the antibodies didn't work as well against the virus—activity was one-to-threefold less, depending on the mutation.

It's a small difference but it is definitely a difference. The antibody response is "not as good" at blocking the virus.

Earlier research established that the two vaccines are about 95% effective in preventing COVID-19 illness.

The latest findings were posted late Tuesday on an online website for researchers 

https://medicalxpress.com/news/2021-01-covid-mutations-dampen-vacci...

Some COVID-19 mutations may dampen vaccine effectiveness

Scientists are reporting troubling signs that some recent mutations of the virus that causes COVID-19 may modestly curb the effectiveness of two current vaccines, although they stress that the shots still protect against the disease.

Researchers expressed concern Wednesday about the preliminary findings, in large part because they suggest that future mutations could undermine vaccines.

A different, more limited study out Wednesday gave encouraging news about one vaccine's protection against some of the mutations.

One way vaccines work is to prompt the immune system to make antibodies that block the virus from infecting cells. The Rockefeller researchers got blood samples from 20 people who had received either the Moderna or Pfizer vaccine and tested their antibodies against various virus mutations in the lab.

With some, the antibodies didn't work as well against the virus—activity was one-to-threefold less, depending on the mutation. It's a small difference but it is definitely a difference. The antibody response is "not as good" at blocking the virus.

Earlier research established that the two vaccines are about 95% effective in preventing COVID-19 illness.

The latest findings were posted late Tuesday on an online website for researchers.

We don't want people thinking that the current vaccine is already outdated. That's absolutely not true. There's still immunity here ... a good level of protection but the mutations "do in fact reduce how well our immune response is recognizing the virus."

We've got an arms race between the vaccines and the virus. The slower we roll out vaccine around the world, the more opportunities we give this virus to escape" and develop mutations

https://www.biorxiv.org/content/10.1101/2021.01.15.426911v1

https://medicalxpress.com/news/2021-01-covid-mutations-dampen-vacci...

Antibiotic resistance may spread even more easily than expected

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers.

Completely different species of bacteria can spread resistance genes to each other through plasmids—small DNA molecules where bacteria store some of their genes outside the chromosome. When two bacterial cells come into contact, they can copy plasmids to each other. This is called conjugation, and it is the most important mechanism for spreading antibiotic resistance.

In recent years, we've seen that resistance genes spread to human pathogens to a much greater degree than anyone expected.

Many of the genes appear to have originated in a wide array of bacterial species and environments, such as soil, water and plant bacteria. This has been difficult to explain, because although conjugation is very common, we've thought that there was a distinct limitation for which bacterial species can transfer plasmids to each other. Plasmids belong to different mobility groups, or MOB groups, so they can't transfer between just any bacterial species.

The results show, among other things, that:

• The number of oriT regions may be almost eight times higher than those found with the standard method used today.
• The number of mobile plasmids may be twice as high as previously known.
• The number of bacterial species that have mobile plasmids may be almost twice as high as previously known.
• Over half of these plasmids have oriT regions that match a conjugation enzyme from another plasmid that has previously been classified in a different MOB group. This means that they could be transferred by one of these plasmids that happens to be in the same bacterial cell.

The last part means that there may be transfer mechanisms between large numbers of bacterial species and environments where we previously believed there were barriers.

Jan Zrimec, Multiple plasmid origin‐of‐transfer regions might aid the spread of antimicrobial resistance to human pathogens, MicrobiologyOpen (2020). DOI: 10.1002/mbo3.1129

https://phys.org/news/2021-01-antibiotic-resistance-easily.html?utm...

Cancer can be precisely diagnosed using a urine test with artificia...

Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pain.

--

Scientists shine new light on heat-damaged hair

A new technique allowed researchers to observe in greater detail how heat alters keratin proteins, helping in their search for ingredients that can prevent heat-damaged hair.

--

As more bacteria grow resistant to antibiotics, scientists are figh...

Scottish bacteriologist Alexander Fleming's discovery of penicillin, the world's first antibiotic, saved countless lives. But even as the bacteria killer first hit the U.S. market—in the closing months of World War II—Fleming warned the world about what penicillin might unleash.

Bubble micro-robots!

Lasers create miniature robots from bubbles

Sci-COM : Storytelling can be a powerful tool for science

Credible science communication and storytelling are not mutually exclusive — they can be great allies.

In contrast with straight communication of experimental results, telling individual research stories portrays science as a human-driven endeavour, full of successes, uncertainties, missteps and failures, which in turn promotes transparency. What really matters is what story is being told and by whom.

https://www.nature.com/articles/d41586-021-00108-w?utm_source=Natur...

S. Africa virus strain poses 're-infection risk': study

The coronavirus variant detected in South Africa poses a "significant re-infection risk" and raises concerns over vaccine effectiveness, according to preliminary research Wednesday, as separate studies suggested the British strain would likely be constrained by immunisations. Several new variants -- each with a cluster of genetic mutations -- have emerged in recent weeks, sparking fears over an increase in infectiousness as well as suggestions that the virus could begin to elude immune response, whether from prior infection or a vaccine. These new variants, detected from Britain, South Africa and Brazil, have mutations to the virus' spike protein, which enables the virus to latch onto human cells and therefore plays a key role in driving infections. But it is one mutation in particular -- known as E484K and present in the variants detected in South Africa and Brazil but not the one from Britain -- that has experts particularly worried about immunity "escape".

They found that it was resistant to neutralising antibodies built up from prior infection, but said more research was needed into the effectiveness of other parts of the immune response.

The 501Y.V2 lineage, which contains nine spike mutations and rapidly emerged in South Africa during the second half of 2020, is largely resistant to neutralising antibodies elicited by infection with previously circulating lineages. This suggests that, despite the many people who have already been infected with SARS-CoV-2 globally and are presumed to have accumulated some level of immunity, new variants such as 501Y.V2 pose a significant re-infection risk.

The researchers added that this might also affect the use of convalescent plasma as a treatment for Covid-19. They also suggested it could have "implications" for vaccines developed based on immune responses to the virus's spike protein.

https://researchnews.cc/news/4730/S--Africa-virus-strain-poses--re-...

Scientists solve a 100-year-old mystery about cancer

In 1921, German physician Otto Warburg observed that cancer cells harvest energy from glucose sugar in a strangely inefficient manner: rather than "burn" it using oxygen, cancer cells do what yeast do—they ferment it. This oxygen-independent process occurs quickly, but leaves much of the energy in glucose untapped.  

Various hypotheses to explain the Warburg effect have been proposed over the years, including the idea that cancer cells have defective mitochondria—their "energy factories"—and therefore cannot perform the controlled burning of glucose. But none of these explanations has withstood the test of time. (Cancer cells' mitochondria work just fine, for example.)
Now a research team  offers a new answer, based on a hefty set of genetic and biochemical experiments and published January 21 in the journal Science.It comes down to a previously unappreciated link between Warburg metabolism and the activity of a powerhouse enzyme in the cell called PI3 kinase. PI3 kinase is a key signaling molecule that functions almost like a commander-in-chief of cell metabolism. Most of the energy-costly cellular events in cells, including cell division, occur only when PI3 kinase gives the cue. As cells shift to Warburg metabolism, the activity of PI3 kinase is increased, and in turn, the cells' commitment to divide is strengthened. It's a bit like giving the commander-in-chief a megaphone.The findings revise the commonly accepted view among biochemists that sees metabolism as secondary to cell signaling. They also suggest that targeting metabolism could be an effective way to thwart cancer growth.

As with immune cells, cancer cells may employ Warburg metabolism as a way to sustain the activity of this signaling pathway and therefore ensure their continued growth and division.

The results raise the intriguing possibility that doctors could curb cancer growth by blocking the activity of LDHA—the Warburg "switch."

 Ke Xu et al, Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity, Science (2021). DOI: 10.1126/science.abb2683

https://medicalxpress.com/news/2021-01-scientists-year-old-mystery-...

**

Combined river flows could send up to 3 billion microplastics a day into the Bay of Bengal

The Ganges River—with the combined flows of the Brahmaputra and Meghna rivers—could be responsible for up to 3 billion microplastic particles entering the Bay of Bengal every day, according to new research.

The study represents the first investigation of microplastic abundance, characteristics and seasonal variation along the river and was conducted using samples collected by an international team of scientists as part of the National Geographic Society's Sea to Source: Ganges expedition.

Over two expeditions in 2019, 120 samples (60 each in pre- and post-monsoon conditions) were gathered at 10 sites by pumping river water through a mesh filter to capture any particles.

The samples were then analysed in laboratories at the University of Plymouth with microplastics found in 43 (71.6%) of the samples taken pre-monsoon, and 37 (61.6%) post-monsoon.

More than 90% of the microplastics found were fibres and, among them, rayon (54%) and acrylic (24%) - both of which are commonly used in clothing—were the most abundant.

Combining predicted microplastic concentration at the mouth of the river (Bhola, Bangladesh) with the discharge of the river, scientists estimate that between 1 billion and 3 billion microplastics might be being released from the Ganges Brahmaputra Meghna River Basin every day.

Imogen E. Napper et al, The abundance and characteristics of microplastics in surface water in the transboundary Ganges River, Environmental Pollution (2021). DOI: 10.1016/j.envpol.2020.116348

https://phys.org/news/2021-01-combined-river-billion-microplastics-...

How Do Bacteria Become Resistant to Antibiotics?

Blue Monday claims are 'pseudo-scientific gibberish, nonsense' - Consultant psychologist

https://www.newstalk.com/news/blue-monday-claims-are-pseudo-scienti...

Those who claim third Monday of Jan., (Blue Monday is the name given to a day in January (typically the third Monday of the month) said by a UK travel company, Sky Travel, to be the most depressing day of the year. The concept was first published in a 2005 press release from the company, which claimed to have calculated the date using an "equation") marks the most depressing day of the year are spouting “pseudo-scientific gibberish,” according to a consultant clinical psychologist.

Over recent years, the third Monday in January has become known as ‘Blue Monday’ – with people struggling to come to terms with long nights, the weather, money problems and unfulfilled resolutions.

Saying that the most depressing thing about Blue Monday is that this pseudo-science, gibberish, nonsense has not been forgotten about and we are still talking about it. It is not a thing. It was invented in 2005 by an advertising company to help a travel company sell holidays; to let us know that we need to book our holidays long in advance. They came up with this gibberish formula that does nothing except make us feel worse about ourselves.

If you look around and see the environment we have right now, we have enough things to be sad and anxious about. We don’t need this on top of everything else. There is zero scientific evidence behind the claims and experts warned of a real danger that it could “become a self-fulfilling prophecy” for people as long as it continues.

People go into it thinking, ‘this is going to be the saddest day of the year’ and in that day then they feel sad because they feel they are supposed to be sad. But no, it isn’t. It is just a day like any other.

People who are feeling down or depressed need support every day of the year, not on “some random day that was picked by an advertising company.” It is completely invalidating to those who are suffering from depression.

It is as useful as getting out the horoscope to predict how the day is going to go. People struggle day in, day out – not on any one given day or because of a date.

Evolution doesn’t work the way you think it does

An evolutionary biologist explains all the things you might get into an argument over

https://massivesci.com/articles/evolution-darwin-fitness-genes-sele...

https://massivesci.com/articles/evolution-darwin-fitness-genes-sele...

--

Lilly antibody reduced Covid-19 risk by 80% in nursing home study

A synthetic antibody developed by Eli Lilly reduced the risk of contracting Covid-19 by 80 percent in a study of nursing home residents when used preventatively, the company said Thursday. Though the result is only preliminary and awaiting peer review, the finding was hailed as highly promising by experts, who said it meant that the infused therapy had the potential to complement vaccines. "We are exceptionally pleased with these positive results, which showed bamlanivimab was able to help prevent COVID-19, substantially reducing symptomatic disease among nursing home residents, some of the most vulnerable members of our society.

The result came from a late-stage clinical trial sponsored by the US government that examined 299 residents and 666 staff of long-term care facilities who tested negative for the virus.

The result came from a late-stage clinical trial sponsored by the US government that examined 299 residents and 666 staff of long-term care facilities who tested negative for the virus, the company said in a press release.

The participants were randomly assigned either 4.2 grams of bamlanivimab, or a placebo.

After eight weeks of follow-up, the risk of developing symptomatic Covid-19 was overall reduced by 57 percent for those receiving the treatment.

In particular, residents on bamlanivimab had a 80 percent lower risk of contracting the disease.

Among the 299 residents, there were four deaths attributed to Covid-19, all in the placebo arm.

https://researchnews.cc/news/4768/Lilly-antibody-reduced-Covid-19-r...

**

Spitting cobra venoms evolved to cause extreme pain.

Airflows inside passenger cars and implications for airborne disease transmission  

How to Have a COVID-Safe Car Ride, According to Science
Sharing a car with someone is one of the riskiest things you can do without cohabitating, as far as coronavirus transmission goes.

While taking a car may feel like a slightly safer alternative compared to public transportation, it's still a small, enclosed space. Even if all passengers are wearing masks, some small particles can escape from the face coverings into the air.

It's usually not significant when you're outdoors, because it gets diluted.   But when you're in a confined space like that of a car, if [the particles] are not flushed out of the cabin, they can remain and build up a concentration with time.

Scientists been modelling how particles may move inside vehicles with various levels of ventilation using fluid mechanics.

These things were found in various simulations:

Rolling down all of the windows was the most effective way to clear out potentiallyvirus-laden particles from a car.  When all windows were closed, 8 percent to 10 percent of the tiny particles one person exhaled could reach another. That number dropped to 0.2 percent to 2 percent when all four windows were open.

But on a chilly winter day, opening all of the windows may not be the most practical option, so the authors experimented with alternatives, and came up with some suggestions.

If you're going to open two windows, pick the ones opposite the driver and passenger
The simulated car was based on a Toyota Prius driving at 50 miles per hour, with a driver in the front left seat and a single passenger in the back right. While a passenger may intuitively crack the window closest to them upon getting in a car, opening the windows opposite the driver (front right) and passenger (back left) provided better ventilation in the model.

In a moving car, fresh air typically flows in through the rear window and out the front window .  Opening the windows opposite the occupants not only provides an entry and exit point for particles, but also creates a current of air separating the passenger from the driver.

However, the difference between the two-windows-open configurations they tested was "marginal."

You should open some windows at least halfway if you're sharing a car, and always wear a mask
Opening car windows is not a foolproof way to avoid coronavirus transmission. Sharing a car with someone outside of your household is a risky move, and opening windows is one way to reduce that risk. But that extra ventilation is not a substitute for other prevention measures, such as mask-wearing, handwashing, and sanitizing common surfaces.

Plastic barriers between driver and passenger could help stop droplets. While such sheets are not a substitute for fresh air, it doesn't hurt to have them. 
The barriers are helpful in preventing all kinds of droplet transmission, including the small ones .
 But a better way is to also have a ventilation system, so that the air inside the cabin gets replenished with fresh air from the outside.

Visual Behavior Modeling for Robotic Theory of Mind

The Blanket Octopus and it's AMAZING Blanket!!

Exciting Study on Mouse Immune Cells Reveals How We Might Reverse Cognitive Decline in old age

New research hints at a cause – and possible solution – for some of the ailments and decline that often come with age.

Scientists have long known that cognitive decline as we get older and specific age-related diseases including Alzheimer's  are linked to inflammation, but they are still uncovering precisely why and how this is the case. 

Research published Wednesday in the journal Nature pinpoints the role of a messenger hormone found in much higher levels in older people, and mice, than their younger counterparts.

When the hormone was blocked in older mice, they were able to perform as well as more youthful rodents in tests of their memory and navigation.

The researchers found that higher levels of the hormone affected the metabolism of immune cells called macrophages, prompting them to store energy rather than consume it.

That ends up effectively starving the cells and sends them into a damaging inflammatory hyperdrive that contributes to age-related cognitive decline and several age-related diseases.

The hormone, prostaglandin E2 (PGE2), "is a major regulator of all types of inflammation, both good and bad, and its effect depends on the receptor that is activated. This new study identified the EP2 receptor... as the receptor that leads to energy depletion and maladaptive inflammation.

Older mice that received the compounds or had the receptor deleted from their genes performed as well as young mice when tested for navigation and spatial memory, both of which deteriorate with ageing and diseases like Alzheimer's.

https://www.nature.com/articles/s41586-020-03160-0

https://www.sciencealert.com/a-study-on-mice-immune-cells-reveals-a...

--

Researchers create new form of cultivated meat

McMaster researchers have developed a new form of cultivated meat using a method that promises more natural flavor and texture than other alternatives to traditional meat from animals.

Your Body Makes 3.8 Million Cells Every Second. Most of Them Are Blood

Deep within, on a cellular scale, your body is in a constant state of activity to keep you alive. Among those processes is the turnover of cells, replacing the cells that die with fresh new ones so that you don't crumble to bits like a zombie.

A new calculation reveals just how intensive that process is. According to biologists Ron Sender and Ron Milo of the Weizmann Institute of Science in Israel, your body replaces around 330 billion cells per day. At that rate, your body is making over 3.8 million new cells every second.

Most of those are blood cells, followed by cells in your gut. Less than 2 percent of your cell turnover is everything else. Confirming these numbers could help scientists better understand how the human body functions and the role cell turnover plays in both health and disease.

It's a common myth that your body completely regenerates all its cells every seven years. The reality is a lot more complicated. Some cells live just a few days, while others – such as neurons in the cerebellum and lipids in the lenses of your eyes – are limited only by the lifespan of the host (you). So humans are very far from a Ship of Theseus situation. However, while scientists have previously worked out estimates for how many cells are in the body, what kind they are, and what their lifespans are, very little work has been done to take a census of the cellular turnover rate.

--

They based their calculations on a standard reference person: a healthy male between the ages of 20 and 30, weighing 70 kilograms (154 pounds) and 170 centimetres (5 feet 7 inches) tall. Then, for their estimation of cell turnover rates, they included every cell type that constitutes over 0.1 percent of the total cell population.

Cell lifespans were collected from a literature survey, using only those works that took direct measurements of the lifespans of human cells. Then they derived the overall cellular mass for each type, based on the average cell mass.

Based on this information, the pair then calculated that their standard reference person would have a cell turnover rate of around 80 grams (2.8 ounces) per day, or 330 billion cells.

Of that turnover by number, 86 percent would be blood cells, mostly erythrocytes (red blood cells, the most abundant cell type in the body) and neutrophils (the most abundant type of white blood cell). Another 12 percent would be gastrointestinal epithelial cells, with small amounts of skin cells (1.1 percent), endothelial cells that line the blood vessels, and lung cells (0.1 percent each).

Although blood cells make up most of cell turnover in terms of individual cell count, by mass it's a different story. Only 48.6 percent of the mass is blood cells, of all types. Gastrointestinal cells make up another 41 percent. Skin cells make up 4 percent, while adipocytes, or fat cells, which barely registered in cell numbers, make up another 4 percent by mass.

https://www.nature.com/articles/s41591-020-01182-9

(If you're wondering what happens to all the dead cells, they either get sloughed off, in the case of skin and gastrointestinal cells, and sometimes slurped up by parasites, or broken down and partially recycled by the body. Waste not, want not!)

https://www.sciencealert.com/your-body-makes-4-million-cells-a-seco...

SARS-CoV-2 needs cholesterol to invade cells and form mega cells

People taking cholesterol-lowering drugs may fare better than others if they catch the novel coronavirus. A new study hints at why: the virus relies on the fatty molecule to get past the cell's protective membrane.

To cause COVID-19, the SARS-CoV-2 virus must force its way into people's cells—and it needs an accomplice. Cholesterol, the waxy compound better known for clogging arteries, helps the virus open cells up and slip inside.

Without cholesterol, the virus cannot sneak past a cell's protectiv... and cause infection. Cholesterol is an integral part of the membranes that surround cells and some viruses, including SARS-CoV-2. It makes sense that it should be so important for infection. The finding might underlie the better health outcomes seen in COVID-19 patients taking cholesterol-lowering drugs known as statins.

This discovery of cholesterol's importance could help scientists develop new stopgap measures to treat COVID-19 until most people are vaccinated.

David W. Sanders et al. SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation, bioRxiv (2020). DOI: 10.1101/2020.12.14.422737

https://phys.org/news/2021-01-sars-cov-cholesterol-invade-cells-meg...

SARS-CoV-2 Needs Cholesterol to Invade Cells

The mystery of the blue flower: nature’s rare colour owes its existence to bee vision

https://theconversation.com/the-mystery-of-the-blue-flower-natures-...

--

Microbes fuelled by wind-blown mineral dust melt the Greenland ice ...

Scientists have identified a key nutrient source used by algae living on melting ice surfaces linked to rising sea levels.The Greenland ice sheet—the second largest ice body in the world after the Antarctic ice sheet—covers almost 80% of the surface of Greenland. Over the last 25 years, surface melting and water runoff from the ice sheet has increased by about 40%.The international research team, led by the University of Leeds, analysed samples from the southwestern margin on Greenland's 1.7 million km2 ice sheet over two years.They discovered that phosphorus containing minerals may be driving ever-larger algal blooms on the Greenland Ice Sheet. As the algal blooms grow they darken the ice surface, decreasing albedo—the ability to reflect sunlight. The blooms cause increased melting thus contributing to higher sea levels. In particular, a band of low-albedo ice, known as the Dark Zone, has developed along the western margin of the massive ice sheet.

--

Puzzling six-exoplanet system with rhythmic movement challenges the...

Using a combination of telescopes, including the Very Large Telescope of the European Southern Observatory (ESO's VLT), astronomers have revealed a system consisting of six exoplanets, five of which are locked in a rare rhythm around their central star. The researchers believe the system could provide important clues about how planets, including those in the Solar System, form and evolve.

Study explores the effects of maternal inflammation on fetal brain development

Research suggests that infections or inflammation in pregnant women can be linked with the development of neurodevelopmental disorders in their offspring. Inflammation during pregnancy (maternal immune activation, or MIA) disrupts fetal brain development and leads to abnormal behavior in offspring. While this association is well-documented, the molecular and neural mechanisms underpinning it are still poorly understood.

 Scientists have recently carried out a study aimed at better understanding how maternal immune activation (MIA) can influence the development of the fetus and potentially facilitate the occurrence of neurodevelopmental disorders. Their paper, published in Nature Neuroscience, shows that MIA can activate a particular neural pathway that regulates the translation of messenger RNA (mRNA) molecules in the brain of pre-natal male mice, disrupting a process known as proteostasis.

The mRNA molecule is essentially a single-stranded molecule of RNA that puts DNA genetic instructions into action. Proteostasis (or protein homeostasis), on the other hand, is the process that regulates proteins within and around cells, maintaining their health and preventing their degradation.

When scientists blocked the ISR, whether using transgenic mice (i.e., mice with genomes altered by humans) or drugs, they were able to reverse the behavioral deficits observed in MIA offspring. Moreover, in pre-natal male mice, blocking the ISR restored balance in cortical neural activity.

Overall, this recent study unveiled specific alterations in protein homeostasis associated with maternal inflammation and occurring predominantly in pre-natal male mice, which could increase the risk of neurodevelopmental disorders in MIA-exposed offspring. In the future, the findings gathered by Kalish, Kim and their colleagues could inspire further research aimed at better understanding such immune-neural interaction, which could ultimately inform the development of strategies to reduce the adverse effects of MIA on the fetal brain.

Maternal immune activation in mice disrupts proteostasis in the fetal brain. Nature Neuroscience(2021). DOI: 10.1038/s41593-020-00762-9.

https://medicalxpress.com/news/2021-01-explores-effects-maternal-in...

**

Study proves potential for reducing pre-term birth by treating fetus as patient

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'. The study has been published in Science Advances.

It has long been suspected that pre-term labor is triggered by inflammation caused by a sick fetus. A new study by scientists at UTMB has proved the hypothesis by studying several important assumptions about the relationship between the health of a mother and her unborn child.

Researchers tested their bioengineered exosomes as a delivery system for anti-inflammatory medicine directly to the fetus. Exosomes are natural nanoparticles or vesicles in our bodies, and we have trillions of them circulating through us at all times. By packaging the medicine inside a bioengineered exosome and injecting it into the mother intravenously, the exosomes travel through the blood system, cross the placental barrier and arrive in the fetus, where they deliver the medicine.

There were several steps prior to testing the drug delivery. First, Menon said it was important to prove that fetal cells, specifically immune cells, actually migrated through the mother's body to her uterine tissues as well as to her, which can cause inflammation, the leading cause of pre-term labor.

To prove migration of cells, female mice were mated with male mice who had been genetically engineered with a red fluorescent dye called tdtomato. The dye causes cells in the male to turn red, so once mating has occurred, cells in the developing fetus also turn red and can easily be tracked as they migrate through the mother.

Once scientists had proof of cell migration, they next used the mouse model to determine if bioengineered exosomes could deliver a special anti-inflammatory medicine, an inhibitor of NF-kB, called super repressor (SR) IkB from the mother's bloodstream to the fetus.

the study found that:

* Sustained effects/delays in labor required repeated dosing
* Prolongation of gestation improved pup viability
* Mouse models provided valuable information to help understand the mechanisms often seen in humans
* Future studies, including human clinical trials are needed to confirm laboratory results

Samantha Sheller-Miller et al, Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models, Science Advances (2021). DOI: 10.1126/sciadv.abd3865

https://medicalxpress.com/news/2021-01-potential-pre-term-birth-fet...

Researchers guide a single ion through a Bose-Einstein condensate

Physicists has now developed a new method to observe a single charged particle on its path through a dense cloud of ultracold atoms. The results were published in Physical Review Letters and are further reported in a Viewpoint column in the journal Physics.

They used a Bose-Einstein condensate (BEC) for their experiments. This exotic state of matter consists of a dense cloud of ultracold atoms. By means of sophisticated laser excitation, the researchers created a single Rydberg atom within the gas. In this giant atom, the electron is a thousand times further away from the nucleus than in the ground state and thus only very weakly bound to the core. With a specially designed sequence of electric field pulses, the researchers snatched the electron away from the atom. The formerly neutral atom turned into a positively charged ion that remained nearly at rest despite the process of detaching the electron.

In the next step, the researchers used precise electric fields to pull the ion in a controlled way through the dense cloud of atoms in the BEC. The ion picked up speed in the electric field, collided on its way with other atoms, slowed down and was accelerated again by the electric field. The interplay between acceleration and deceleration by collisions led to a constant motion of the ion through the BEC.

This new approach allowed the researchers to measure the mobility of a single ion in a Bose-Einstein condensate for the very first time.

T. Dieterle et al. Transport of a Single Cold Ion Immersed in a Bose-Einstein Condensate, Physical Review Letters (2021). DOI: 10.1103/PhysRevLett.126.033401

https://phys.org/news/2021-01-ion-bose-einstein-condensate.html?utm...

Optimal information about the invisible

Laser beams can be used to precisely measure an object's position or velocity. Normally, however, a clear, unobstructed view of this object is required—and this prerequisite is not always satisfied. In biomedicine, for example, structures are examined, which are embedded in an irregular, complicated environment. There, the laser beam is deflected, scattered and refracted, often making it impossible to obtain useful data from the measurement.

Researchers have now been able to show that meaningful results can be obtained even in such complicated environments. Indeed, there is a way to specifically modify the laser beamso that it delivers exactly the desired information in the complex, disordered environment—and not just approximately, but in a physically optimal way: Nature does not allow for more precision with coherent laser light. The new technology can be used in very different fields of application, even with different types of waves, and has now been presented in the scientific journal Nature Physics.

Dorian Bouchet et al. Maximum information states for coherent scattering measurements, Nature Physics (2021). DOI: 10.1038/s41567-020-01137-4

https://phys.org/news/2021-01-optimal-invisible.html?utm_source=nwl...

Apple warns to keep iPhone 12, MagSafe accessories "safe distance" from medical devices

Apple is warning owners of the iPhone 12 and any MagSafe charging accessories to keep the gadgets at a "safe distance" from medical devices.

According to a support page on Apple's website updated Saturday, the tech giant advises owners keep medical devices at least 6 inches away from medical devices, or 12 inches if they are wirelessly charging.

The iPhone 12 as well as MagSafe, a line of accessories including cases built to make wirelessly charging the smartphones easier, contain magnets to help connect better. The smartphones also have "components and radios that emit electromagnetic fields."

The support page says devices like implanted pacemakers "might contain sensors that respond to magnets and radios when in close contact."

Apple suggests users get in touch with their doctor or the maker of their medical device to find out what type of impact the new iPhone or accessories might have.

A recent study in the Heart Rhythm journal tested the compatibility of the iPhone 12 with a patient who had a Medtronic Implantable Cardioverter Defibrillator (ICD), which is used to manage cardiac rhythms. The study claimed when the iPhone was brought close to the ICD, "immediate suspension of ICD therapies was noted which persisted for the duration of the test."

https://support.apple.com/en-in/HT211900

https://techxplore.com/news/2021-01-apple-iphone-magsafe-accessorie...

The police used the emergency ping feature to locate a kidnapped woman and rescue her.

An Apple Watch helped the police track down a kidnapped woman in the US. Police in Selma, Texas were able to reportedly use the emergency SOS feature on Apple Watch to locate a kidnapped woman and rescue her. The Apple Watch offered accurate location data of the victim, thanks to which the police were able to rush to her. This isn't the first time the Apple Watch has been reported to have saved a life. A few months ago, the Apple Watch's heart monitoring feature helped a 25-year-old in detecting irregularity in his heartbeat and potentially saving his life.

https://gadgets.ndtv.com/wearables/news/apple-watch-helped-rescue-k...

Time-restricted eating 

When—not what—obese mice ate reduced breast cancer risk

Restricting eating to an eight-hour window, when activity is highest, decreased the risk of development, growth and metastasis of breast cancer in mouse models, report researchers.

The findings, published in the January 25, 2021 edition of Nature Communications, show that time-restricted feeding—a form of intermittent fasting aligned with circadian rhythms—improved metabolic health and tumor circadian rhythms in mice with obesity-driven postmenopausal breast cancer.

Previous research has shown that obesity increases the risk of a variety of cancers by negatively affecting how the body reacts to insulin levels and changing circadian rhythms. Now researchers were able to increase insulin sensivity, reduce hyperinsulinemia, restore circadian rhythms and reduce tumour growth by simply modifying when and for how long mice had access to food.

Both obesity and menopause can disrupt circadian rhythms, which in turn can lead to the development of insulin resistance, predisposing individuals to chronic diseases like cancer.

Data indicates that elevated insulin levels in obese mice are driving the accelerated tumor growth. Artificially elevating insulin levels accelerated tumor growth, whereas reducing insulin levels could mimic the effect of the time-restricted feeding. The results suggest that the antitumor effect of time-restricted feeding is due to improving metabolic health and lowering the levels of insulin.

Time-restricted eating has a positive effect on metabolic health and does not trigger the hunger and irritability that is associated with long-term fasting or calorie restriction," said Das. "Through its beneficial metabolic effects, time-restricted eating may also provide an inexpensive, easy to adopt, but effective strategy to prevent and inhibit breast cancer without requiring a change in diet or physical activity.

Manasi Das et al. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models, Nature Communications (2021). DOI: 10.1038/s41467-020-20743-7

https://medicalxpress.com/news/2021-01-whennot-whatobese-mice-ate-b...

Microwaves used to deactivate coronavirus, flu, other aerosolized viruses

Studies indicate the COVID-19 virus may be contained in aerosols that can be generated and spread through breathing, coughing, sneezing, or talking by infected individuals. Researchers are increasingly focused on developing tools and methods to assist in decontaminating surfaces and spaces.

While scientists have previously explored the use of electromagnetic energy to deactivate flu virus in bulk fluids, less work has been done to understand the role of nonionizing radiation, such as microwaves, in reducing the infectivity of viral pathogens in aerosols. The tools required to both safely contain contaminated aerosol streams and expose these aerosols to controlled, well-characterized microwave doses have not been readily available.

In Review of Scientific Instruments, researchers from the Air Force Research Laboratory report development of a set of experimental tools capable of presenting electromagnetic waves to an aerosol mixture of biological media and virus with the capability to vary power, energy, and frequency of the electromagnetic exposure. The researchers seek to better characterize the threshold levels of microwave energy needed to inactivate aerosolized viral particles and, thus, reduce their ability to spread infection.

In teh initial expts., 

researchers are exposing a human-safe coronavirus surrogate, bovine coronavirus, to a range of microwave waveforms at frequencies ranging from 2.8 GHz to 7.5 GHz.

"The bovine coronavirus is similar in size and configuration to human coronavirus but is safe to human.

"Apparatus for controlled microwave exposure of aerosolized pathogens" Review of Scientific Instruments, aip.scitation.org/doi/10.1063/5.0032823

https://medicalxpress.com/news/2021-01-microwaves-deactivate-corona...

Discovery makes the invisible visible

Australian scientists have discovered a new way to analyze microscopic cells, tissues and other transparent specimens, through the improvement of an almost 100-year-old imaging technique.

--

Supercomputers aid scientists studying the smallest particles in th...

Since the 1930s, scientists have been using particle accelerators to gain insights into the structure of matter and the laws of physics that govern our world. These accelerators are some of the most powerful experimental tools available, propelling particles to nearly the speed of light and then colliding them to allow physicists to study the resulting interactions and particles that form.

--

Dogs synchronize their behavior with children, but not as much as w...

Dogs synchronize their behavior with the children in their family, but not as much as they do with adults, a new study from Oregon State University researchers found.

Physicists discover new physical effect

Scientists have found that a perpendicular magnetic field makes electrically neutral quasiparticles (excitons) in semiconductors behave like electrons in the Hall effect. This discovery will help researchers to study the physics of excitons and Bose-Einstein condensates.

The Hall effect can be achieved by applying a magnetic field in a direction perpendicular to the current flow of a semiconductor or a metal plate. In this case, all the electrons will deflect to one side, which will accumulate a negative charge, while the other side has a positive charge. This results in voltage between the right and left end faces of the plate.

physicists have recently discovered a similar effect but for excitons, composite neutral quasiparticles. It occurs when a laser affects a semiconductor plate of gallium arsenide, for example, in the presence of a magnetic field. The new phenomenon was called the anomalous exciton Hall effect.

"If you take a thin stripe of a semiconductor material and put it under a laser beam at the right angle, you'll create a directed flow of exciton gas. By applying a perpendicular magnetic field to this film, you will make the exciton cloud deflect to one side. And this is a complete analog of the Hall effect—but for neutrally charged composite quasiparticles.

This effect will help researchers separate bright and dark excitons. When exciton gas is formed, some excitons are able to emit light once the electron returns to its place. Such quasiparticles are called bright excitons. Other excitons disappear without light emission—these are dark excitons. Although it is especially difficult to study and obtain them because both types of quasiparticles are created simultaneously, the proposed method for separating bright excitons from dark ones will successfully resolve this issue.the discovered effect is unlikely to be as widely applied Hall effect technologies used in smartphones, but it may be highly valuable for scientists who study excitons. In particular, it will greatly simplify the study of such mind-blowing and complex states of matter as Bose-Einstein condensates.

 V. K. Kozin et al. Anomalous Exciton Hall Effect, Physical Review Letters (2021). DOI: 10.1103/PhysRevLett.126.036801

https://phys.org/news/2021-01-physicists-physical-effect.html?utm_s...

Exercising muscle combats chronic inflammation on its own

Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors. The results appear online on January 22 in the journal Science Advances. 

--

Exercising muscle combats chronic inflammation on its own

Exercising lab-grown human muscle autonomously blocks the damaging effects of interferon gamma

Biomedical engineers have demonstrated that human muscle has an innate ability to ward off damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors.

Zhaowei Chen, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, Nenad Bursac. Exercise Mimetics and JAK Inhibition Attenuate IFN-γ-induced Wasting in Engineered Human Skeletal Muscle. Science Advances, 2021 DOI: 10.1126/sciadv.eabd9502

https://www.sciencedaily.com/releases/2021/01/210122140624.htm

https://researchnews.cc/news/4805/Exercising-muscle-combats-chronic...

--

Technology could upend DNA sequencing for diagnosing certain DNA mu...

Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.

Strange colon discovery explains racial disparities in colorectal cancer

The colons of African Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer.

Scientists found that one side of the colon ages biologically faster than the other in both African Americans and people of European descent. In African Americans, however, the right side ages significantly faster, explaining why African Americans are more likely to develop cancerous lesions on the right side and why they are more likely to suffer colorectal cancer at a younger age, the researchers say.

The researchers made this determination by looking at the DNA in colon tissue, and the “epigenetic” changes that come with age. These epigenetic changes are not alterations to the genes, but changes that affect how the genes work and how well they can do their jobs.

The scientists found that the right side of the colon in most African Americans had suffered a unique pattern of “hypermethylation,” affecting gene expression. It was, in essence, like the right side was old beyond its years. This, the researchers believe, could contribute to African Americans’ increased cancer risk and could explain why they are more likely to develop cancerous lesions on the right side.

The research could also explain why younger people of European descent are more likely to develop lesions on the left side – the side that tends to age faster in that group.

These findings highlight the importance of colon sidedness to biology of colorectal cancer.

https://academic.oup.com/jnci/advance-article-abstract/doi/10.1093/...

https://news.virginia.edu/content/strange-colon-discovery-explains-...