Common agricultural pesticide may be putting hummingbirds at risk: U of T study

Hummingbirds need an incredible amount of energy to flap their wings 50 times per second to maintain hovering flight. Their metabolism is so supercharged that if they were human-sized they would consume energy at a rate more than 10 times that of an Olympic marathon runner. But a new University of Toronto study has found that a common agricultural pesticide, which is related to nicotine in tobacco and  might be slowing down the crucial physiological process  that makes hummingbirds so unique upto 25% in the hours after exposure.

https://www.nature.com/articles/s41598-021-82470-3

https://www.utoronto.ca/news/common-agricultural-pesticide-may-be-p...

Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first

The research paves the way for cell therapies to treat liver disease – in other words, growing ‘mini-bile ducts’ in the lab as replacement parts that can be used to restore a patient’s own liver to health – or to repair damaged organ donor livers, so that they can still be used for transplantation.

Bile ducts act as the liver’s waste disposal system, and malfunctioning bile ducts are behind a third of adult and 70 per cent of children’s liver transplantations, with no alternative treatments. There is currently a shortage of liver donors: This means that only a limited number of patients can benefit from this therapy.

Approaches to increase organ availability or provide an alternative to whole organ transplantation are urgently needed. Cell-based therapies could provide an advantageous alternative. However, the development of these new therapies is often impaired and delayed by the lack of an appropriate model to test their safety and efficacy in humans before embarking in clinical trials.

Now, in a study published in Science, scientists have developed a new approach that takes advantage of a recent ‘perfusion system’ that can be used to maintain donated organs outside the body. Using this technology, they demonstrated for the first time that it is possible to transplant biliary cells grown in the lab known as cholangiocytes into damaged human livers to repair them. As proof-of-principle for their method, they repaired livers deemed unsuitable for transplantation due to bile duct damage. This approach could be applied to a diversity of organs and diseases to accelerate the clinical application of cell-based therapy.

https://science.sciencemag.org/content/371/6531/839

https://www.sanger.ac.uk/news_item/lab-grown-mini-bile-ducts-used-t...

https://researchnews.cc/news/5261/Lab-grown--mini-bile-ducts--used-...

Dancing DNA

Dancing DNA

This video allows us to see, for the first time, how small circles of DNA adopt dance-like movements inside a cell. Being able to observe DNA in such detail could help to accelerate the development of new gene therapies.

Electronics free, air-powered robot

Engineers have created a four-legged soft robot that doesn’t need any electronics to work. The robot only needs a constant source of pressurized air for all its functions, including its controls and locomotion systems.

No more popping pills, now just inhale your antibiotics!

You may not have to pop up azithromycin pills in the future. Instead, you will be able to simply inhale this most common antibiotic drug widely prescribed to treat respiratory tract infections of the nose, throat and lungs.

You may not have to pop up azithromycin pills in the future. Instead, you will be able to simply inhale this most common antibiotic drug widely prescribed to treat respiratory tract infections of the nose, throat and lungs.

Researchers of M S University’s Faculty of Pharmacy have received a patent for their invention of a liposomal dry powder inhaler (LDPI) of azithromycin. This invention will significantly reduce the side effects that the drug causes to people who consume it currently in pill form.

Azithromycin is a widely prescribed drug for the treatment of respiratory tract infections. But as the drug enters the stomach and blood, it causes a number of side effects. There has always been a demand for a formulation that can help the drug reach its target organ — the organ where the bacteria that is causing respiratory infection resides — without causing side effects.

The team developed the new formulation by encapsulating azithromycin within liposomes (used as a carrier), converting it into a dry powder by freeze-drying and filling it in capsules. Patients can easily take drug doses through dry powder inhalers.
The liposomal dry powder was evaluated using various in-vitro and animal studies. The in-vivo studies done on rats showed that the liposomes are retained in the lungs for a prolonged period of up to 12 hours with lesser presence in blood.

“These liposomes slowly released the loaded azithromycin into the lungs and thus avoided the exposure of the drug to stomach or blood. This helps in building local drug concentrations required for maximizing effectiveness and minimizing side effects.

https://health.economictimes.indiatimes.com/news/industry/no-more-p...

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Novel coronavirus affects male fertility levels: Study

City gynaecologists and fertility experts have found that the novel coronavirus has affected the fertility levels, particularly in men, as a majority of those infected hailed from the reproductive age.

As the body temperature is directly linked to the production of sperm, those suffering from Covid-19 with high fever, are at risk of infertility, though temporary. Fertility experts said fever has an impact on the parameters of sperm, including its motility and count. The worst-hit during the lockdown were the infertile couples as they could not have access to assisted reproductive techniques (ART). Even after relaxation in the lockdown, the access to the ART is limited.

The result of the study was published in the recent issue of ‘The Journal of Reproductive Health and Medicine’.

https://health.economictimes.indiatimes.com/news/industry/novel-cor...

Russia detects first case of H5N8 avian flu in humans

Russia said Saturday that its scientists had detected the world's first case of transmission of the H5N8 strain of avian flu from birds to humans and had alerted the World Health Organization.

scientists at the Vektor laboratory had isolated the strain's genetic material from seven workers at a poultry farm in southern Russia, where an outbreak was recorded among the birds in December.

The workers did not suffer any serious health consequences, she added. They are believed to have caught the virus from poultry on the farm.

Information about the world's first case of transmission of the avian flu (H5N8) to humans has already been sent to the World Health Organization. 

There are different subtypes of avian influenza viruses.

While the highly contagious strain H5N8 is lethal for birds, it had never before been reported to have spread to humans.

The discovery of these mutations when the virus has not still acquired an ability to transmit from human to human gives us all, the entire world, time to prepare for possible mutations and react in an adequate and timely fashion.

People can get infected with avian and swine influenza viruses, such as bird flu subtypes A(H5N1) and A(H7N9) and swine flu subtypes such as A(H1N1).

According to the WHO, people usually get infected through direct contact with animals or contaminated environments, and there is no sustained transmission among humans.

H5N1 in people can cause severe illness and has a 60 percent mortality rate.

source: The Lancet

https://medicalxpress.com/news/2021-02-russia-case-h5n8-avian-flu.h...

Hedge plant effective at filtering automobile air pollutants

Researchers have found that the Cotoneaster franchetii (also known as Franchet's cotoneaster) hedge plant is effective at filtering automobile air pollutants. In their paper published in the journal Environments, they described experiments that involved testing different types of plants to find out which were best at filtering air pollution next to roadways.

The work is part of a 10-year ongoing research effort meant to better understand which plants might be the most useful in urban settings. They have been testing bushes, trees and shrubs that are commonly planted in urban to see which are the most effective against flooding and air pollution. Over that time span, they have tested a wide variety of hedges to see how well they can soak up air pollution generated by cars and trucks and have found that those with dense canopies and rough and hairy leaves, such as cotoneaster, are the most effective.

The team found that cotoneaster was 20% more effective at pulling pollutants out of the air on busy street sections than any other hedge that they studied. They acknowledge that they found little difference between hedges when testing on streets that did not have much traffic. They suggest this indicates that using different kinds of plants in different areas would make sense, both for home owners and city or town planners. They found that over the course of one week, a single 1-meter-long cotoneaster hedge was able to clean auto pollutants over the course of a 500-mile drive.

Because of its unique abilities, the researchers suggest that homeowners who have property abutting busy street sections plant cotoneaster to reduce the amount of pollution they are inhaling into their lungs every day. City planners could do likewise to reduce overall pollution levels in cities.

Tijana Blanuša et al. Evaluating the Effectiveness of Urban Hedges as Air Pollution Barriers: Importance of Sampling Method, Species Characteristics and Site Location, Environments (2020). DOI: 10.3390/environments7100081

https://phys.org/news/2021-02-hedge-effective-filtering-automobile-...

Unfortunate timing and rate of change may be enough to tip a climat...

Imagine abrupt shifts of the tropical monsoons, reductions in Northern Hemisphere rainfall, and strengthening of North Atlantic storm tracks within decades. These are some of the impacts that climate scientists expect if the Atlantic Meridional Overturning Circulation (AMOC), which redistributes heat from equatorial regions to the Northern Hemisphere, suddenly tips into a dormant state as a result of global warming. The consequences would drastically alter conditions for agriculture, biodiversity, and the economy in large parts of the World.

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Drones used to locate dangerous, unplugged oil wells

There are millions of unplugged oil wells in the United States, which pose a serious threat to the environment. Using drones, researchers from Binghamton University, State University of New York have developed a new method to locate these hard-to-locate and dangerous wells.

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Carpets of moss help stop erosion

Every year, billions of tons of valuable soil are lost worldwide through erosion, much of it deposited in bodies of water that fill with sand or silt as a result. Soil losses measured in Germany range from 1.4 to 3.2 tons per hectare per year; in extreme weather, the figure can be as high as fifty tons. Geoscientists at the University of Tübingen have now shown how biological soil crusts provide a protective layer against erosion. Natural "carpets" of bacteria, mosses, lichens, fungi and other organisms bind soil particles into coherent layers, or crusts.

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Potentially harmful chemicals found in plastic toys

It has long been known that several chemicals used in plastic toys in different parts of the world can be harmful to human health. However, it is difficult for parents to figure out how to avoid plastic toys containing chemicals that may cause possible health risks to their children.

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How outdoor pollution affects indoor air quality

If you thought you could head indoors to be safe from the air pollution that plagues your area or city, new research shows that elevated air pollution events  claw their way into indoor spaces.

Researchers found that the amount of air pollution that comes indoors depends on the type of outdoor pollution. Wildfires, fireworks and wintertime inversions all affect indoor air to different degrees.

 During their experiments, researchers found  that in general, the pollution levels inside were about 30% of what they were outside.

That's not surprising because during inversions, only around 20% of the air pollution is what's called primary pollution—the particulate matter that comes directly from combustion exhaust. The rest is secondary—formed as gases undergo chemical reactions under specific meteorological conditions and combine to form solid particulates. As soon as the air comes indoors, those meteorological conditions change.

That changes the chemical environment for these particles and they actually dissociate. That's what we're suspecting is happening when these particles come into the building and that's why we don't observe them.

But still the air is still safer inside than outside.

Daniel Mendoza et al, Long-term analysis of the relationships between indoor and outdoor fine particulate pollution: A case study using research grade sensors, Science of The Total Environment (2021). DOI: 10.1016/j.scitotenv.2021.145778

https://phys.org/news/2021-02-outdoor-pollution-affects-indoor-air....

Ghost particle from shredded star reveals cosmic particle accelerator

From a black hole to the South Pole: Scientists identify first neutrino from a tidal disruption event

Tracing back a ghostly particle to a shredded star, scientists have uncovered a gigantic cosmic particle accelerator. The subatomic particle, called a neutrino, was hurled towards Earth after the doomed star came too close to the supermassive black hole at the centre of its home galaxy and was ripped apart by the black hole's colossal gravity. It is the first particle that can be traced back to such a 'tidal disruption event' (TDE) and provides evidence that these little understood cosmic catastrophes can be powerful natural particle accelerators.

The observations also demonstrate the power of exploring the cosmos via a combination of different 'messengers' such as photons (the particles of light) and neutrinos, also known as multi-messenger astronomy.

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The neutrino began its journey some 700 million years ago, around the time the first animals developed on Earth. That is the travel time the particle needed to get from the far-away, unnamed galaxy (catalogued as 2MASX J20570298+1412165) in the constellation Delphinus (The Dolphin) to Earth. Scientists estimate that the enormous black hole is as massive as 30 million suns. "The force of gravity gets stronger and stronger, the closer you get to something. That means the black hole's gravity pulls the star's near side more strongly than the star's far side, leading to a stretching effect. This difference is called a tidal force, and as the star gets closer, this stretching becomes more extreme. Eventually it rips the star apart, and then we call it a tidal disruption event. It's the same process that leads to ocean tides on Earth, but luckily for us the moon doesn't pull hard enough to shred the Earth.

About half of the star's debris was flung into space, while the other half settled on a swirling disc around the black hole.  Before plunging into oblivion, the matter from the accretion disc gets hotter and hotter and shines brightly. This glow was first detected by the Zwicky Transient Facility (ZTF) on Mount Palomar in California on 9 April 2019.

Half a year later, on 1 October 2019 the IceCube neutrino detector at the South Pole registered an extremely energetic neutrino from the direction of the tidal disruption event. It smashed into the Antarctic ice with a remarkable energy of more than 100 teraelectronvolts. For comparison, that's at least ten times the maximum particle energy that can be achieved in the world's most powerful particle accelerator, the Large Hadron Collider at the European particle physics lab CERN near Geneva.The extremely lightweight neutrinos hardly interact with anything, able to pass unnoticed through not just walls but whole planets or stars, and are hence often referred to as ghost particles. So, even catching just one high-energy neutrino is already a remarkable observation. Analysis showed that this particular neutrino had only a one in 500 chance of being purely coincidental with the TDE. The detection prompted further observations of the event with many instruments across the electromagnetic spectrum, from radio waves to X-rays.

- A tidal disruption event coincident with a high-energy neutrino; Robert Stein, Sjoert van Velzen, Marek Kowalski, et al.; Nature Astronomy, 2021, DOI: 10.1038/s41550-020-01295-8

- A concordance scenario for the observed neutrino from a tidal discruption event; Walter Winter and Cecilia Lunardini; Nature Astronomy, 2021, DOI: 10.1038/s41550-021-01305-3

https://www.eurekalert.org/pub_releases/2021-02/ded-gpf021821.php

Using Light To Revolutionize Medical Imaging

Simply speaking while infected can potentially spread COVID-19

COVID-19 can spread from asymptomatic but infected people through small aerosol droplets in their exhaled breath. Most studies of the flow of exhaled air have focused on coughing or sneezing, which can send aerosols flying long distances.

However, speaking while near one another is also risky since the virus can be ejected by merely talking.

In Physics of Fluids, scientists in Japan use smoke and laser light to study the flow of expelled breath near and around two people conversing in various relative postures commonly found in the service industry, such as in hair salons, medical exam rooms, or long-term care facilities.

In this study, electronic cigarettes were used to produce artificial smoke consisting of droplets about one-tenth micron in diameter, similar to the size of a virus particle. The liquid used in these vaping devices, a mixture of glycerin and propylene glycol, produces a cloud of tiny droplets that scatter light from a laser, allowing visualization of airflow patterns.

To study the effect of speech on exhalation, the word "onegaishimasu," a typical Japanese greeting in a business setting. The experiments revealed the exhaled air from an unmasked person who is speaking tends to move downward under the influence of gravity. If a customer or patient is lying below, they could be infected. When a mask is worn while standing or sitting, the vapor cloud tends to attach to that person's body, which is warmer than the surrounding air and flows upward along the body. If the technician is leaning over, however, the aerosol cloud tends to detach from that person's body and fall onto the client below.

The investigators also experimented with face shields and found it can prevent any aerosols that leak from around the technician's mask from traveling down to the customer.

"The face shield promoted the rise of the exhaled breath," said Ishii. "Hence, it is more effective to wear both a mask and a face shield when providing services to customers."

"Relationship between human exhalation diffusion and posture in face-to-face scenario with utterance" Physics of Fluids (2021). DOI: 10.1063/5.0038380

https://phys.org/news/2021-02-simply-infected-potentially-covid-.ht...

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Researchers are turning kitchen waste into biofuels

When we eat, our bodies convert food into energy that fuels our lives. But what happens to the energy stored in the several billion pounds of food thrown away annually?

As part of advancing sustainable energy solutions, scientists are converting food waste into clean, renewable fuel that could power our planes, trains and automobiles. Researchers successfully converted food waste  into an energy-dense biofuel that could help replace today's fossil fuels. Early results suggest food waste might deliver a trifecta of efficiency, economic and environmental benefits.

scientists pursuing this  begin by blending the waste, often with the help of customized equipment known as the Muffin Monster that grinds up everything from bones and gristle to seeds, wrappers and packaging. The resulting mush is warmed so it can be continuously pumped into a reactor and converted into fuel.

The researchers are testing different types of food waste to see if they can achieve consistent outcomes. During experiments, they address numerous chemical and process engineering challenges as they arise. They fine-tune the heat exchange design, resolve pumping issues and develop continuous separation techniques.

https://phys.org/news/2021-02-kitchen-biofuels.html?utm_source=nwle...

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Can we regenerate damaged organs in the lab?

Scientists are trying to do just that!

More than 87,000 scientific papers on coronavirus since pandemic

Study finds "astonishing" growth even as partnerships shrink

 Scientists from around the world have published more than 87,000 papers about coronavirus between the start of the COVID-19 pandemic and October 2020, a new analysis shows.

Even given the importance of the pandemic, researchers were surprised by the huge number of studies and other papers that scientists produced on the subject in such a short time.

Nearly all of the scientific community around the world turned its attention to this one issue.

https://www.eurekalert.org/pub_releases/2021-02/osu-mt8022221.php

Physicists Just Reached a New Speed Limit For Moving Quantum Information

This latest research answers a fundamental question – how fast can a quantum process be? It's a useful piece of information to know if you want to build a quantum computer or a quantum network, as it tells you some of the limitations inherent in the system.

https://journals.aps.org/prx/abstract/10.1103/PhysRevX.11.011035

https://www.sciencealert.com/a-new-quantum-speed-limit-discovery-sh...

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Scientists begin building highly accurate digital twin of our planet

A digital twin of our planet is to simulate the Earth system in future. It is intended to support policy-makers in taking appropriate measures to better prepare for extreme events. A new strategy paper by European scientists and ETH Zurich computer scientists shows how this can be achieved.

How to improve your life using science

https://www.sciencefocus.com/science/improve-your-life-with-science...

Asteroid dust found in crater closes case of dinosaur extinction

Researchers think they have closed the case of what killed the dinosaurs, definitively linking their extinction with an asteroid that slammed into Earth 66 million years ago by finding a key piece of evidence: asteroid dust inside the impact crater.

Death by asteroid rather than by a series of volcanic eruptions or some other global calamity has been the leading hypothesis since the 1980s, when scientists found asteroid dust in the geologic layer that marks the extinction of the dinosaurs. This discovery painted an apocalyptic picture of dust from the vaporized asteroid and rocks from impact circling the planet, blocking out the sun and bringing about mass death through a dark, sustained global winter—all before drifting back to Earth to form the layer enriched in asteroid material that's visible today.

Researchers collected nearly 3,000 feet of rock core from the crater buried under the seafloor. Research from this mission has helped fill in gaps about the impact, the aftermath and the recovery of life.

The telltale sign of asteroid dust is the element iridium—which is rare in the Earth's crust, but present at elevated levels in certain types of asteroids. An iridium spike in the geologic layer found all over the world is how the asteroid hypothesis was born. In the new study, researchers found a similar spike in a section of rock pulled from the crater. In the crater, the sediment layer deposited in the days to years after the strike is so thick that scientists were able to precisely date the dust to a mere two decades after impact.

"Globally distributed iridium layer preserved within the Chicxulub impact structure" Science Advances (2021). advances.sciencemag.org/lookup … .1126/sciadv.abe3647

https://phys.org/news/2021-02-asteroid-crater-case-dinosaur-extinct...

New study suggests supermassive black holes could form from dark matter

A new theoretical study has proposed a novel mechanism for the creation of supermassive black holes from dark matter. The international team find that rather than the conventional formation scenarios involving 'normal' matter, supermassive black holes could instead form directly from dark matter in high density regions in the centers of galaxies. The result has key implications for cosmology in the early Universe, and is published in Monthly Notices of the Royal Astronomical Society.

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Exactly how supermassive black holes initially formed is one of the biggest problems in the study of galaxy evolution today. Supermassive black holes have been observed as early as 800 million years after the Big Bang, and how they could grow so quickly remains unexplained.

Standard formation models involve normal baryonic matter—the atoms and elements that that make up stars, planets, and all visible objects—collapsing under gravity to form black holes, which then grow over time. However the new work investigates the potential existence of stable galactic cores made of dark matter, and surrounded by a diluted dark matter halo, finding that the centers of these structures could become so concentrated that they could also collapse into supermassive black holes once a critical threshold is reached.

According to the model this could have happened much more quickly than other proposed formation mechanisms, and would have allowed supermassive black holes in the early Universe to form before the galaxies they inhabit, contrary to current understanding.

Carlos R. Argüelles, the researcher at Universidad Nacional de La Plata and ICRANet who led the investigation comments: "This new formation scenario may offer a natural explanation for how supermassive black holes formed in the early Universe, without requiring prior star formation or needing to invoke seed black holes with unrealistic accretion rates."

Another intriguing consequence of the new model is that the critical mass for collapse into a black hole might not be reached for smaller dark matter halos, for example those surrounding some dwarf galaxies. The authors suggest that this then might leave smaller dwarf galaxies with a central dark matter nucleus rather than the expected black hole. Such a dark matter core could still mimic the gravitational signatures of a conventional central black hole, whilst the dark matter outer halo could also explain the observed galaxy rotation curves.

Carlos R Argüelles et al, On the formation and stability of fermionic dark matter haloes in a cosmological framework, Monthly Notices of the Royal Astronomical Society (2020). DOI: 10.1093/mnras/staa3986

https://phys.org/news/2021-02-supermassive-black-holes-dark.html?ut...

World's first video of a space-time crystal

A research  team has succeeded in creating a micrometer-sized space-time crystal consisting of magnons at room temperature. With the help of the scanning transmission X-ray microscope Maxymus at Bessy II at Helmholtz Zentrum Berlin, they were able to film the recurring periodic magnetization structure in a crystal.

Superstructures formed by 'walking' molecules could help create neu...

Superstructures formed by 'walking' molecules could help create neurons for regenerative medicine

If surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries?! And imagine if they could grow these neurons in the laboratory from a patients own cells using a synthetic, highly bioactive material that is suitable for 3D printing. By discovering a new printable biomaterial that can mimic properties of brain tissue, Northwestern University researchers are now closer to developing a platform capable of treating these conditions using regenerative medicine. A key ingredient to the discovery is the ability to control the self-assembly processes of molecules within the material, enabling the researchers to modify the structure and functions of the systems from the nanoscale to the scale of visible features.

 A research group  has demonstrated that these superstructures can enhance neuron growth, an important finding that could have implications for cell transplantation strategies for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, as well as spinal cord injury.

This is the first example where researchers have been able to take the phenomenon of molecular reshuffling we reported in 2018 and harness it for an application in regenerative medicine.

https://onlinelibrary.wiley.com/doi/10.1002/advs.202004042

https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202004042

Low educational attainment is a risk factor for Alzheimer’s disease and other forms of dementia, suggesting that high educational attainment is associated with fostering neuroanatomical conditions that protect our brain from the pathophysiologic changes of Alzheimer’s disease. This remarkable scientific finding supports the idea that high quality education and science literacy physiologically and functionally strengthen the brain, protecting us from the threat of false beliefs during times of uncertainty and crisis.

Could comedy offer a way to communicate science more effectively?

Conference to explore adapting science communication to new challenges

https://www.irishtimes.com/news/science/could-comedy-offer-a-way-to...

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How wildfires may have larger effects on cloud formation than previ...

As the frequency and size of wildfires continues to increase worldwide, new research from Carnegie Mellon University scientists shows how the chemical aging of the particles emitted by these fires can lead to more extensive cloud formation and intense storm development in the atmosphere. The research was published online today in the journal Science Advances.

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Titan's atmosphere recreated in an Earth laboratory

Beyond Earth, the general scientific consensus is that the best place to search for evidence of extraterrestrial life is Mars. However, it is by no means the only place. Aside from the many extrasolar planets that have been designated as "potentially-habitable," there are plenty of other candidates right here in our solar system. These include the many icy satellites that are thought to have interior oceans that could harbor life.

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How plant stem cells renew themselves—a cytokinin story

The mechanism by which the plant hormone cytokinin controls cell division has been discovered—a breakthrough that significantly improves our understanding of how plants grow.

How obesity affects skin infections

The list of diseases and conditions complicated by obesity is a long one; it includes heart disease, cancer, diabetes and impaired wound healing, as well as skin infections. It is not always clear, however, in what way this complication is caused. New research published last month in Science Translational Medicine, has uncovered the mechanisms that link obesity and skin infections, and identified a treatment option that will soon be tested in a Phase 2 clinical trial.

The work is focused on discovering links between disease and the epithelial microbiome—that is, the normal bacteria that live on our skin—and how the skin's defense system can be optimized to treat or prevent disease. In this study, the goal was to identify how obesity contributes to higher rates of atopic dermatitis.

During the studies it was found that when mice 're fed a high fat diet and became obese as result, skin adipocytes (or fat cells) become enlarged and lost the ability to fight against bacterial invasion during a skin infection. The findings revealed that an increased number of mature adipocytes (fat cells) increases TGFβ signaling, which in turn decreases the number dermal adipocyte progenitors that produce an antimicrobial peptide called cathelicidin. This absence leaves the epidermis vulnerable to infection from common culprits like Staphylococcus aureus. In lean subjects (both mice and human in this study), the skin microbiome was successful in preventing Staph infections, as the number of mature fat cells was insufficient to disrupt the normal dermal fat functions that keep such infections at bay.

 Ling-juan Zhang et al. Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors, Science Translational Medicine (2021). DOI: 10.1126/scitranslmed.abb5280

https://medicalxpress.com/news/2021-02-obesity-infection-link-treat...

Forests' long-term capacity to store carbon is dropping in regions with extreme annual fires

Researchers have analyzed decades' worth of data on the impact of repeated fires on ecosystems across the world. Their results, published today in the journal Nature Ecology and Evolution, show that repeated fires are driving long-term changes to tree communities and reducing their population sizes.

Savannah ecosystems, and regions with extreme wet or dry seasons were found to be the most sensitive to changes in fire frequency. Trees in regions with moderate climate are more resistant. Repeated fires also cause less damage to tree species with protective traits like thicker bark.

These effects only emerge over the course of several decades: the effect of a single fire is very different from repeated burning over time. The study found that after 50 years, regions with the most extreme annual fires had 72% lower wood area—a surrogate for biomass—with 63% fewer individual trees than in regions that never burned. Such changes to the tree community can reduce the forest's long-term ability to store carbon, but may buffer the effect of future fires.

Pellegrini, A.F.A. et al: 'Decadal changes in fire frequencies shift tree communities and functional traits.' Nature Ecology & Evolution, February 2021. DOI: 10.1038/s41559-021-01401-7

• More intense and frequent fires are reducing the size of tree communities in many regions of the world.
• Slower-growing tree species are better at surviving fires, but these may capture less atmospheric carbon and reduce nutrient availability in the soil.
• Not all regions are suitable for planting trees to tackle climate change; schemes must consider local wildfire frequency, vegetation cover and climate, and how these might change over time.

https://phys.org/news/2021-02-forests-long-term-capacity-carbon-reg...

Nanobodies could help CRISPR turn genes on and off

The genetic tool CRISPR has been likened to molecular scissors for its ability to snip out and replace genetic code within DNA. But CRISPR has a capability that could make it useful beyond genetic repairs. CRISPR can precisely locate specific genes.

Scientists now attached CRISPR to nanobodies to help it perform specific actions when it reached the right spot on DNA. They used this combo technique to transform CRISPR from a gene-editing scissors into a nanoscale control agent that can toggle specific genes on and off, like a light switch, to start or stop the flow of some health-related protein inside a cell.

This  could enable researchers to explore new therapeutic applications in the field of epigenetics—which is the study of how genes behave inside cells.

Mike V. Van et al, Nanobody-mediated control of gene expression and epigenetic memory, Nature Communications (2021). DOI: 10.1038/s41467-020-20757-1

https://phys.org/news/2021-02-nanobodies-crispr-genes.html?utm_sour...

Scientists achieve breakthrough in culturing corals and sea anemones cells

Researchers have perfected the recipe for keeping sea anemone and coral cells alive in a petri dish for up to 12 days. The new study has important applications to study everything from evolutionary biology to human health.

Cnidarians are emerging model organisms for cell and molecular biology research. Yet, successfully keeping their cells in a laboratory setting has proved challenging due to contamination from the many microorganisms that live within these marine organisms or because the whole tissue survive in a culture environment.

Researchers used two emerging model organisms in developmental and evolutionary biology—the starlet sea anemone (Nematostella vectensis) and cauliflower coral (Pocillopora damicornis)—to find more successful way to grow these cell cultures in a laboratory setting. They tested 175 cell cultures from the two organisms and found that their cells can survive for on average 12 days if they receive an antibiotic treatment before being cultured.

James D. Nowotny et al, Novel methods to establish whole-body primary cell cultures for the cnidarians Nematostella vectensis and Pocillopora damicornis, Scientific Reports (2021). DOI: 10.1038/s41598-021-83549-7

https://phys.org/news/2021-02-scientists-breakthrough-culturing-cor...

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 How reliable are existing studies on microplastics in table salt?

Just as environmentally conscious scientists predicted, our excessive use of plastics is coming back to bite us. Microplastics (MPs), plastic particles smaller than a few millimeters, can now be found everywhere, but more so in seawater. As expected, MPs are harmful to both environment and health, although their exact effects are unclear.

To get a better grasp of the extent of the MP problem, it is necessary to quantify how much we are exposed to them. Table salt has been shown to contain MPs, making it an ideal study target to gauge human exposure to MPs. Although many studies have measured the concentration of MPs in different edible salts, each research group used vastly different methodologies of quantification, causing much variability between the results, and calling into question their validity.

To address this problem, in a study published in the Journal of Hazardous Materials, scientists from Incheon National University, Korea, conducted a systematic review of all published papers on MPs in table salt and analyzed the differences between their methodologies and results in detail.

They found that the concentration of MPs in edible salt according to the literature varied quite a bit, and that measurement and sample-preparation procedures of each study were causing these differences. However, the largest differences were caused by the methods used to identify MPs, the minimum cut-off size and the criteria for the selection of particles. 

When not corrected by different measured minimum MP cutoff sizes, MP content differed from 10 to 600 times among different MP identification methods, with greatest values originating from visual observation and followed by spectroscopy methods

Scientists also found a notable correlation between logarithmic mean abundances of MPs and minimum cut-off size used, regardless of the identification method.

Hee-Jee Lee et al, Variation and Uncertainty of Microplastics in Commercial Table Salts: Critical Review and Validation, Journal of Hazardous Materials (2020). DOI: 10.1016/j.jhazmat.2020.123743

https://phys.org/news/2021-02-salt-reliable-microplastics-table.htm...

**

Dancing Roots

Microscopic Wrinkles in Leaves Ward Off Bugs

Crops have advanced a formidable vary of methods to beat back hungry, leaf-chomping bugs. Properly-known defenses embrace foul-tasting toxins, sticky resins and sharp thorns, and now scientists have recognized one more instance: microscopic wrinkles that make leaves more durable to stroll on.

Wrinkles kind in lots of leaves’ cuticles—coatings that restrict water evaporation, mediate gasoline alternate, and shield the plant from pathogens. The brand new analysis, revealed in Royal Society Open Science, finds that together with the cuticle’s inherently slippery floor, its tiny wrinkles additionally assist discourage bugs. The wrinkles most certainly grow to be extra pronounced because the leaf matures and its cuticle builds up, ultimately increasing and buckling.

https://royalsocietypublishing.org/doi/10.1098/rsos.201319

Were it not for humans, woolly mammoths would have lived for 4,000 more years, simulation shows

An international team of researchers has used computer simulations to show that it was likely a combination of climate change and human hunting that led to the extinction of the woolly mammoth. They have written a paper describing their findings, available on the bioRxiv preprint server—in it, they suggest that were it not for human hunters, the mammoths would have lasted another 4,000 years.

the researchers created a simulation showing wooly mammoth populations from approximately 21,000 years ago, to 4,000 years ago—the time when the last of the mammoths died out. To recreate conditions the mammoths faced, the researchers added climate data as well as known human hunting data. They ran their simulation over 90,000 times with slight changes to the factors that might have led to their demise. The simulations showed that the most likely scenario involved climate change pushing the mammoths into smaller environments and hunters finishing them off. Interestingly, the researchers also found that if they removed human hunters from the simulations, the majority of the mammoths held on for another 4,000 years.

 Damien A. Fordham et al. Humans hastened the range collapse and extinction of woolly mammoth, bioRxiv (2021). DOI: 10.1101/2021.02.17.431706

https://phys.org/news/2021-02-humans-woolly-mammoths-years-simulati...

Scientists use Doppler to peer inside cells

Doppler radar improves lives by peeking inside air masses to predict the weather. A Purdue University team is using similar technology to look inside living cells, introducing a method to detect pathogens and treat infections in ways that scientists never have before.

In a new study, the team used Doppler to sneak a peek inside cells and track their metabolic activity in real time, without having to wait for cultures to grow. Using this ability, the researchers can test microbes found in food, water, and other environments to see if they are pathogens, or help them identify the right medicine to treat antibiotic-resistant bacteria.

Researchers worked with immortalized cell lines—cells that will live forever unless you kill them. They exposed the cells to different known pathogens, in this case salmonella and E. coli. They then used the Doppler effect to spy out how the cells reacted. These living cells are called "sentinels," and observing their reactions is called a biodynamic assay.

This strategy is broadly applicable when scientists have isolated an unknown microbe and want to know if it is pathogenic—harmful to living tissues—or not. Such cells may show up in food supply, water sources or even in recently melted glaciers.

Another benefit is the ability to quickly and directly diagnose which bacteria respond to which antibiotics.

 Honggu Choi et al, Doppler imaging detects bacterial infection of living tissue, Communications Biology (2021). DOI: 10.1038/s42003-020-01550-8

https://phys.org/news/2021-02-scientists-doppler-peer-cells.html?ut...

https://www.youtube.com/watch?v=mwr-wF_IMeU

https://www.youtube.com/watch?v=9nzkF0hmy04

https://www.youtube.com/watch?v=I1Bdp2tMFsY

Study suggests habitat loss is leading to inbreeding of Indian tigers

While Indian tigers have the highest genetic variation compared to other subspecies of the feline across the world, their populations continue to be fragmented by loss of habitat, leading to inbreeding and potential loss of this diversity, says a new study.

 Habitat loss from human activities leads to tigers being "hemmed into their own protected area. Now, they can only mate with the other tigers in their own population. Over time, this will result in inbreeding, they will end up mating with their relatives. This  inbreeding might compromise their fitness and their ability to survive.

While genetic diversity across a population improves their chances of survival in the future, the study said population fragmentation of tigers can decrease this variation, and endanger them further.

https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msa...

In the study, the scientists sequenced whole genomes from 65 individual tigers from four subspecies of the feline, and conducted a variety of population genomic analyses that quantify genetic variability. They investigated the partitioning of genetic variation, possible impacts of inbreeding, and demographic history, and possible signatures of local adaptation.

While the total genomic variation in Indian tigers was higher than in other subspecies, the study found that several individual tigers in the country had low variation, suggesting possible inbreeding.

https://www.thehindu.com/sci-tech/energy-and-environment/study-sugg...

How an ancient virus spread the ability to remember

A protein in your brain behaves like a virus, infecting your cells with memories

Forming a protective shell, Arc moves from neuron to neuron

X-factor to help antibiotics regain their spark

Researchers find a single-celled slime mold with no nervous system that remembers food locations

Having a memory of past events enables us to take smarter decisions about the future. Researchers now identified the basis for forming memories in the slime mold Physarum polycephalum—despite its lack of a nervous system.

The ability to store and recover information gives an organism a clear advantage when searching for food or avoiding harmful environments, and has been traditionally linked to organisms that have a nervous system. A new study challenges this view by uncovering the surprising abilities of a highly dynamic,single-celled organism to store and retrieve information about its environment.

The slime mold Physarum polycephalum has been puzzling researchers for many decades. Existing at the crossroads between the kingdoms of animals, plants and fungi, this unique organism provides insight into the early evolutionary history of eukaryotes. Its body is a giant single cell made up of interconnected tubes that form intricate networks. This single amoeba-like cell may stretch several centimeters or even meters, featuring as the largest cell on earth in the Guinness Book of World Records.

The striking abilities of the slime mold to solve complex problems such as finding the shortest path through a maze earned it the attribute "intelligent," intrigued the research community and kindled questions about decision making on the most basic levels of life. The decision-making ability of Physarum is especially fascinating given that its tubular network constantly undergoes fast reorganization—growing and disintegrating its tubes—while completely lacking an organizing center. The researchers discovered that the organism weaves memories of food encounters directly into the architecture of the network-like body and uses the stored information when making future decisions.

Researchers followed the migration and feeding process of the organism and observed a distinct imprint of a food source on the pattern of thicker and thinner tubes of the network long after feeding. Given P. polycephalum's highly dynamic network reorganization, the persistence of this imprint sparked the idea that the network architecture itself could serve as memory of the past.

The researchers combined microscopic observations of the adaption of the tubular network with theoretical modeling. An encounter with food triggers the release of a chemical that travels from the location where food was found throughout the organism and softens the tubes in the network, making the whole organism reorient its migration towards the food.

The gradual softening is where the existing imprints of previous food sources come into play and where information is stored and retrieved. Past feeding events are embedded in the hierarchy of tube diameters, specifically in the arrangement of thick and thin tubes in the network. For the softening chemical that is now transported, the thick tubes in the network act as highways in traffic networks, enabling quick transport across the whole organism. Previous encounters imprinted in the network architecture weigh into the decision about the future direction of migration.

Mirna Kramar et al. Encoding memory in tube diameter hierarchy of living flow network, Proceedings of the National Academy of Sciences (2021). DOI: 10.1073/pnas.2007815118

https://phys.org/news/2021-02-single-celled-slime-mold-nervous-food...

Caterpillar silences tomato's cry for help, scientists find

"Silencing the alarm."

Scientists found that a caterpillar called the tomato fruit worm not only chomps on tomatoes and their leaves, but also deposits enzyme-laden saliva on the plant, interfering with its ability to cry for help.

 It has been shown time and time again that when under attack, plants can emit chemical distress signals, causing their peers to mount some sort of defense. A classic example is the smell of a freshly mown lawn, which prompts the release of protective compounds in nearby blades of grass that have yet to be cut.

In some cases, plant distress signals can even summon help from other species. That's what happens with the tomato. When caterpillars nibble on the plant's leaves, the leaf pores release volatile chemicals that are detected by a type of parasite: a wasp that lays eggs inside caterpillars. 

So can the caterpillars strike back? In a series of experiments, researchers found that the answer was yes, illustrating a previously unknown strategy in nature's age-old contest between predator and prey.

The key is the enzyme in the caterpillar's saliva, which inhibits the opening of pores in tomato-plant leaves. That means the leaves are less able to release the distress signals, and presumably less able to attract wasps that could come to the rescue.

 Po‐An Lin et al. Silencing the alarm: an insect salivary enzyme closes plant stomata and inhibits volatile release, New Phytologist (2021). DOI: 10.1111/nph.17214

https://phys.org/news/2021-02-horror-movie-caterpillar-silences-tom...

Swift Links Neutrino to Star-destroying Black Hole

https://fb.watch/3Yp8kldIDt/

A single male lyrebird can mimic the sound of an entire flock

The masters of imitation appear to have vocal talents more profound than previously appreciated

Coronavirus transmission through the placenta: Baby infected with coronavirus in the womb

A pregnant woman with suspected COVID-19 was rushed by ambulance to Skåne University Hospital, in Malmo, Sweden, suffering from sudden severe abdominal pain. The doctors noticed that the unborn infant had an abnormally low heart rate, which can be a sign that the baby is not getting enough oxygen.

The doctors performed an emergency caesarean section and delivered the baby within minutes. Blood tests from the baby confirmed it had severely low oxygen, and throat swabs showed that both mother and baby were suffering from COVID.

Using throat swabs from the mother and the newborn, the genome of the virus was sequenced to confirm the possibility that the infant had been infected with COVID while still in the womb.

 a few days later, new genetic sequencing showed that the baby’s virus population had changed and contained a mutated version of the virus along with the original virus strain from the mother. To the best of our knowledge, this is the first case of a genetic change of the coronavirus in the unique setting of mother-to-foetus transmission before birth.

Although it is common for viruses to mutate, this mutation (called A107G) happened just five days after the baby was delivered. The genetic changes may have been stimulated by the baby coming in contact with the external environment outside the mother’s womb. However, it was surprising how quickly this single mutation occurred.

The most important findings were the changes seen in the placenta. The placenta takes blood and nutrients to the foetus and takes away waste and is critical for the growth and wellbeing of the foetus. Half the tissue was damaged. There was widespread inflammation, and  coronavirus protein was found on both the mother’s and foetus’s side of the placenta. Also found was coronavirus protein in all areas that were damaged by inflammation.

 with thousands of pregnant women infected worldwide, mother-to-baby transmission in the womb seems to be a rare complication of COVID during pregnancy.

Scientists think that this is because of the placental barrier that protects the baby in the womb from most infections. Also, the vital receptor needed for coronavirus entry into cells, called an ACE-2 receptor, only exists in low levels in the placenta.

In rare cases, coronavirus can damage the placenta – leading to a lack of oxygen in the unborn child – even if the mother has a mild case of COVID in late pregnancy. 

we should rethink how we monitor pregnant women who have COVID, and they should be considered a more important risk group than we do today.

https://theconversation.com/baby-infected-with-coronavirus-in-the-w...

**

Carbon Capture Research 

Huge, Global Study of Plastic Toys Finds Over 100 Substances That May Harm Children

The potential health risks of chemicals used in plastic toys have had scientists concerned for years, but new research reveals just how widespread the risk of harm to children remains.

In an international study, researchers assessed the chemical compositions of toys and estimated levels of human exposure to the substances, ultimately finding over 100 "Chemicals of Concern" in plastic toy materials that could pose a non-negligible health risk to children.

Out of 419 chemicals found in hard, soft, and foam plastic materials used in children toys, researchers identified 126 substances that can potentially harm children's health either via cancer or non-cancer effects, including 31 plasticisers, 18 flame retardants, and 8 fragrances.

According to the researchers, while laws in many countries regulate the use of certain potentially toxic chemicals in plastic toys, there is no consistent approach internationally, and current protections don't adequately prohibit the vast extent of potentially harmful substances that toys are made from

In addition, some toxic and banned additives are still found in plastic toys also on regulated markets, for example in case of recycling contaminated plastics, unawareness by producers, or absence of regulations in the producing country.

https://www.sciencedirect.com/science/article/pii/S0160412020321498

https://www.sciencealert.com/plastic-toy-study-finds-over-100-subst...

Biomass-based plastics

The Oldest Known Mummification 'Recipe' Has Been Unearthed, And It's Intense

In an exciting discovery, researchers have discovered an original 'how to' manual, hidden inside an ancient text, which explains the crucial steps to embalming and creating a mummy.

The guide to mummification has been found on a 3,500-year-old piece of papyrus called the Papyrus Louvre-Carlsberg manuscript, so called because half of it, primarily containing medical information.

Among the details that Schiødt has teased out of the document is a list of instructions for embalming the face of the deceased person, which was done with a piece of red linen coated in a special plant-based solution.

The solution included aromatic substances as well as binders for holding the mixture together, and the saturated cloth was intended to keep the face protected from insects and bacteria while also smelling sweet. This process hasn't been documented before, but does match up with some of the mummified remains that have been found.

This manuscript also lays out the full 70-day schedule for embalming, split into two halves: a 35-day drying period and a 35-day wrapping period, which were themselves divided into four-day intervals. Common treatments to the body included applying a mixture called natron, after the removal of the organs and the brain. 

https://news.ku.dk/all_news/2021/02/ancient-egyptian-manual-reveals...

https://www.sciencealert.com/the-oldest-known-mummification-recipe-...

People Are Accidentally Poisoning Themselves Trying to Treat COVID With a Horse Drug

People are trying to treat and prevent COVID-19 by taking ivermectin, a medication commonly used to de-worm horses – and they are poisoning themselves in the process.

The buzz around ivermectin has been generated by the FLCCC, the Front Line COVID-19 Critical Care Alliance (FLCCC), which formed at the start of the pandemic. It comprises critical care workers who previously bonded over the controversial use of vitamin C for sepsis, MedPage Today reported.

US regulators say there is not enough robust evidence or safety data to recommend ivermectin as a cure, treatment, or preventative medicine for COVID-19.

While the FLCCC has held press conferences saying studies show the drug could fight against the novel coronavirus, public health agencies and many experts say the research is lacking. 

Ivermectin can be tolerated in small doses but can poison an adult in large quantities 

https://www.businessinsider.com.au/coronavirus-people-are-accidenta...

Structure and dynamics of key receptor in migraine pain determined, paving way for better treatment options

A research team determined the shape and kinetics of an important cell surface (membrane) receptor called calcitonin gene-related peptide (CGRP), which has long been implicated in migraine. The researchers  determined the structure of the receptor alone and in combination with its natural target molecule (CGRP). This gives us a clear understanding of how the receptor works during its normal function in the body. The work has been published in the journal Science.

Future studies will expand the investigations towards potential drug targets.

Tracy M. Josephs et al. Structure and dynamics of the CGRP receptor in apo and peptide-bound forms, Science (2021). DOI: 10.1126/science.abf7258

Migraine is more than a simple headache; more than 3 million migraineurs—more than 60% of whom are women—have at least one attack per year. A smaller subset experience chronic migraine, defined by migraine pain that occurs 15 days or more per month, for three or months in a row. While sufferers experience many different symptoms of varying intensity—usually nausea, dizziness, sensitivity to light and sound, and intense pain on one or both sides of the head—the physiological process of migraine onset and pain is different from other types of headache, such as muscle tension or sinus pain. While migraine was long believed to be a neurovascular disorder that involved dilation of vessels in the skull, face and cerebral membrane, research has excluded vasodilation as a factor in this type of pain. More recent work has identified increased CGRP in the trigeminal se... that results in headache.

https://medicalxpress.com/news/2021-03-dynamics-key-receptor-migrai...

Animals fake death for long periods to escape predators

Many animals feign death to try to escape their predators, with some individuals in prey species remaining motionless, if in danger, for extended lengths of time.

Charles Darwin recorded a beetle that remained stationary for 23 minutes—however the University of Bristol has documented an individual antlion larvae pretending to be dead for an astonishing 61 minutes. Of equal importance, the amount of time that an individual remains motionless is not only long but unpredictable. This means that a predator will be unable to predict when a potential prey item will move again, attract attention, and become a meal.

Predators are hungry and cannot wait indefinitely. Similarly, prey may be losing opportunities to get on with their lives if they remain motionless for too long. Thus, death-feigning might best be thought of as part of a deadly game of hide and seek in which prey might gain most by feigning death if alternative victims are readily available.

The study, published today in science journal Biology Letters, involved evaluating the benefits of death-feigning in terms of a predator visiting small populations of conspicuous prey. Researchers used computer simulations that utilise the marginal value theorem, a classical model in optimization.

 Hide-and-seek strategies and post-contact immobility, Biology Letters (2021). royalsocietypublishing.org/doi … .1098/rsbl.2020.0892

https://phys.org/news/2021-03-animals-fake-death-periods-predators....

Color blindness-correcting contact lenses

Imagine seeing the world in muted shades—gray sky, gray grass. Some people with color blindness see everything this way, though most can't see specific colors. Tinted glasses can help, but they can't be used to correct blurry vision. And dyed contact lenses currently in development for the condition are potentially harmful and unstable. Now, in ACS Nano, researchers report infusing contact lenses with gold nanoparticles to create a safer way to see colors.

Color blindness-correcting contact lenses

Imagine seeing the world in muted shades—gray sky, gray grass. Some people with color blindness see everything this way, though most can't see specific colors.

Now researchers report infusing contact lenses with gold nanoparticles to create a safer way to see colors.

Some daily activities, such as determining if a banana is ripe, selecting matching clothes or stopping at a red light, can be difficult for those with colour blindness. Most people with this genetic disorder have trouble discriminating red and green shades, and red-tinted glasses can make those colors more prominent and easier to see. However, these lenses are bulky and the lens material cannot be made to fix vision problems. Thus, researchers have shifted to the development of special tinted contact lenses. Although the prototype hot-pink dyed lenses improved red-green color perception in clinical trials, they leached dye, which led to concerns about their safety. Gold nanocomposites are nontoxic and have been used for centuries to produce "cranberry glass" because of the way they scatter light. 

To make the contact lenses, the researchers evenly mixed gold nanoparticles into a hydrogel polymer, producing rose-tinted gels that filtered light within 520-580 nm, the wavelengths where red and green overlap. The most effective contact lenses were those with 40 nm-wide gold nano particles, because in tests, these particles did not clump or filter more color than necessary. In addition, these lenses had water-retention properties similar to those of commercial ones and were not toxic to cells growing in petri dishes in the lab. Finally, the researchers directly compared their new material to two commercially available pairs of tinted glasses, and their previously developed hot-pink dyed contact lens. The gold nanocomposite lenses were more selective in the wavelengths they blocked than the glasses. The new lenses matched the wavelength range of the dyed contact lenses, suggesting the gold nanocomposite ones would be suitable for people with red-green color issues without the potential safety concerns. The researchers say that the next step is to conduct clinical trials with human patients to assess comfort.

Ahmed E. Salih et al. Gold Nanocomposite Contact Lenses for Color Blindness Management, ACS Nano (2021). DOI: 10.1021/acsnano.0c09657

https://phys.org/news/2021-03-blindness-correcting-contact-lenses.h...