Scientists uncover a missing link between poor diet and higher cancer risk

A research team has unearthed new findings that may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet. The insights gained from this study hold promise for advancing cancer prevention strategies aimed at promoting healthy aging.

Cancer is caused by the interaction between our genes and factors in our environment, such as diet, exercise, and pollution. How such environmental factors increase cancer risk is not yet very clear, but it is vital to understand the connection if we are to take preventive measures that help us stay healthy longer.

A chemical linked to diabetes, obesity, and poor diet can heighten cancer risk

The research team first studied patients who are at a high risk of developing breast or ovarian cancers because they inherit a faulty copy of the cancer gene—BRCA2—from their parents. They demonstrated that cells from such patients were particularly sensitive to the effects of methylglyoxal, which is a chemical produced when our cells break down glucose to create energy.

The study showed that this chemical can cause faults in our DNA that are early warning signs of cancer development.

The team's research also suggested that people who do not inherit a faulty copy of BRCA2 but could experience higher-than-normal levels of methylglyoxal—such as patients with diabetes or pre-diabetes, which are connected with obesity or poor diet—can accumulate similar warning signs indicating a higher risk of developing cancer.

This research suggests that patients with high methylglyoxal levels may have higher cancer risk. Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker. Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer.

Interestingly, the research team's work also revised a longstanding theory about certain cancer-preventing genes. This theory—called the Knudson's 'two-hit' paradigm—was first formulated in 1971, and it was proposed that these genes must be inactivated permanently in our cells before cancer can arise.

The NUS team has now found that methylglyoxal can temporarily inactivate such cancer-preventing genes, suggesting that repeated episodes of poor diet or uncontrolled diabetes can 'add up' over time to increase cancer risk. This new knowledge is likely to be influential in changing the direction of future research in this area.

Li Ren Kong et al, A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2, Cell (2024). DOI: 10.1016/j.cell.2024.03.006

Study of data from thousands of women suggests ovarian cycle is regulated by circadian rhythm

A team of reproductive researchers affiliated with several institutions in France and the U.S. has found that the timing of monthly ovarian cycles in women is mostly likely attributable to the circadian rhythm. In their paper published in the journal Science Advances, the group describes their study of thousands of ovarian cycles as reported by thousands of women in Europe and the U.S. and what they found.

The timing mechanism behind the ovarian cycle has mystified scientists for centuries, though one of the strongest theories has been that it is tied to the lunar cycle*. Charles Darwin suggested that the two became linked back when humans lived near the seashore, where the tides heavily impacted daily scheduling.

And three years ago a team led by Würzburg chronobiologist Charlotte Förster found evidence for women's menstrual cycles temporarily synchronizing with cycles of the moon.

In this new effort, the research team has found little evidence of a lunar impact—they suggest the mechanism most likely controlling the ovarian cycle is the circadian rhythm.

* C. Helfrich-Förster el al., "Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon," Science

advances (2021). advances.sciencemag.org/lookup … .1126/sciadv.abe1358

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The circadian rhythm is defined as physical, mental, and behavioral changes that organisms, such as humans, experience over 24-hour cycles. One of the most famous behaviors impacted by the circadian rhythm is sleep—people tend to feel sleepy at the same time every night. However, it has also been noted that the circadian rhythm can be impacted by the lunar cycle—people have been found to go to bed later and sleep less, for example, on nights before a full moon.

To learn more about the ovarian cycle-controlling mechanism, the research team obtained medical records for over 3,000 women living in Europe and North America, which held data relating to 27,000 ovarian cycles. The team tracked the first day of each cycle for all the women under study. In doing so, they found little correlation between cycle start time and lunar cycling.

The researchers did find something else, though. Many examples of what they describe as phase jumps—where something disturbs the timing of a cycle for a given woman, and the body responds by changing the clock rhythm over several months to bring the cycle back to its original norm. They compare it to how the circadian rhythm reacts to people experiencing jet lag. This, they suggest, indicates that the circadian rhythm is much more likely the mechanism that controls ovarian cycling.

 René Ecochard et al, Evidence that the woman's ovarian cycle is driven by an internal circamonthly timing system, Science Advances (2024). DOI: 10.1126/sciadv.adg9646

Part 2

Paper straws contain more potentially toxic ‘forever chemicals’ than plastic. Should you give them up?

Many paper straws tested by scientists contain significant amounts of chemicals that don't biodegrade.

If you have been following the scientific debate on the effect of different types of straw on the environment and human health, you’ll know that the decision whether to use a straw or not  is not an easy one.

Pictures of plastic straws causing the death of turtles and other aquatic life were published in national newspapers. Governments scrambled to justify they had let plastic pollution reach such an appalling state of affairs – they singled out plastic straws as something that they could ban. And so they did, ignoring those of us who warned about the unexpected consequences.

A study by a European research group showed there are significant health and environmental risks associated with the pape... that have replaced plastic straws.

Scientists observing the performance of the new paper straws found themselves puzzled by their ability to repel liquids and resist getting soggy. Could there be an additive, they wondered, that might be allowing paper straws to perform so well?

Part 1

They studied plastic, paper and plant-based straws obtained in the USA. It showed that paper and plant-based straws contain PFAS (Per- and polyfluoroalkyl substances).

These are fluorine-based chemicals that have remarkable properties in repelling water, grease and pretty much anything. They are widely used in products designed to resist water and oil such as raincoats, furniture, cookware and food packaging.

PFAS are chemically and thermally very stable which means that almost nothing reacts or degrades them. This means they persist in the environment and will do so for thousands of years. For this reason, they have been dubbed ‘forever chemicals’.

They have been found literally everywhere from the Arctic ice to the Amazon rainforest. They also make it into the human body by migrating from packaging into our food and drink.

Once PFAS are in our blood they are associated with a number of health effects such as liver and kidney disease. There is also evidence that PFAS may lead to increased risk of high blood pressure in pregnant ..., and decreased immune response. Some studies show an association of PFAS exposure with kidney and testicular cancer. They have been shown to harm wildlife too.

All the evidence points to paper and plant-based straws having significant PFAS in them. PFAS have also been found in plastic straws but at lower levels. The only material determined to be free of PFAS was stainless steel.

Stainless steel straws  are reusable and easy to clean. So I use only them.

Please use only steel straws.

**

Discovery of the first fractal molecule in nature

An international team of researchers has stumbled upon the first regular molecular fractal in nature. They discovered a microbial enzyme—citrate synthase from a cyanobacterium—that spontaneously assembles into a pattern known as the Sierpinski triangle. Electron microscopy and evolutionary biochemistry studies indicate that this fractal may represent an evolutionary accident.

The study is published in Nature.

Snowflakes, fern leaves, romanesco cauliflower heads: many structures in nature have a certain regularity. Their individual parts resemble the shape of the whole structure. Such shapes, which repeat from the largest to the smallest, are called fractals. But regular fractals that match almost exactly across scales, as in the examples above, are very rare in nature.

Molecules also have a certain regularity. But if you look at them from a great distance, you can no longer see any signs of this. Then you see smooth matter whose features no longer match those of the individual molecules. The degree of fine structure we see depends on our magnification—in contrast to fractals, where self-similarity persists at all scales. In fact, regular fractals at the molecular level are completely unknown in nature till now.

This is somewhat surprising. After all, molecules can assemble themselves into all sorts of wonderful shapes. Scientists have extensive catalogues of self-assembled complex molecular structures. However, there has never been a regular fractal among them. It turns out that almost all regular-looking self-assemblies lead to the kind of regularity that becomes smooth on large scales.

Researchers now discovered a microbial enzyme—citrate synthase from a cyanobacterium—that spontaneously assembles into a regular fractal pattern known as the Sierpiński triangle. This is an infinitely repeating series of triangles made up of smaller triangles.

The protein makes these beautiful triangles and as the fractal grows, we see these larger and larger triangular voids in the middle of them, which is totally unlike any protein assembly we've ever seen before.

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How did this unusual exception emerge? What distinguishes the enzyme from all others, causing it to form a fractal shape? Teaming up with structural biologist at the university of Marburg, the team eventually managed to determine the molecular structure of this assembly using electron microscopy, which illuminated how it achieves its fractal geometry.
It now became clear how exactly this protein manages to assemble into a fractal: Normally, when proteins self-assemble, the pattern is highly symmetrical: each individual protein chain adopts the same arrangement relative to its neighbors. Such symmetrical interactions always lead to patterns that become smooth on large scales.

The key to the fractal protein was that its assembly violated this rule of symmetry. Different protein chains made slightly different interactions at different positions in the fractal. This was the basis for forming the Sierpiński triangle, with its large internal voids, rather than a regular lattice of molecules.

Self-assembly is often used by evolution to regulate enzymes, but in this case the cyanobacterium that this enzyme is found in does not seem to care much whether or not its citrate synthase can assemble into a fractal.
When the team genetically manipulated the bacterium to prevent its citrate synthase from assembling into the fractal triangles, the cells grew just as well under a variety of conditions. This prompted them to wonder whether this might just be a harmless accident of evolution. Such accidents can happen when the structure in question isn't too difficult to construct.
To test their theory, the team recreated the evolutionary development of the fractal arrangement in the laboratory. To do this, they used a statistical method to back-calculate the protein sequence of the fractal protein as it was millions of years ago.

By then producing these ancient proteins biochemically they were able to show that the arrangement arose quite suddenly through a very small number of mutations and was then immediately lost again in several cyanobacterial lineages, so that it only remained intact in this single bacterial species.
The fact that something so complex-looking as a molecular fractal could emerge so easily in evolution suggests that more surprises and much beauty may still lie hidden in so far undiscovered molecular assemblies of many biomolecules.

Franziska L. Sendker et al, Emergence of fractal geometries in the evolution of a metabolic enzyme, Nature (2024). DOI: 10.1038/s41586-024-07287-2

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Tropical forests can't recover naturally without fruit eating birds, carbon recovery study shows

New research illustrates a critical barrier to natural regeneration of tropical forests. Their models—from ground-based data gathered in the Atlantic Forest of Brazil—show that when wild tropical birds move freely across forest landscapes, they can increase the carbon storage of regenerating tropical forests by up to 38%.

Fruit eating birds such as the Red-Legged Honeycreeper, Palm Tanager, or the Rufous-Bellied Thrush play a vital role in forest ecosystems by consuming, excreting, and spreading seeds as they move throughout a forested landscape.

Between 70% to 90% of the tree species in tropical forests are dependent on animal seed dispersal. This initial process is essential for allowing forests to grow and function. While earlier studies have established that birds are important for forest biodiversity, researchers now have a quantitative understanding of how they contribute to forest restoration. The new study, published in the journal Nature Climate Change provides evidence of the important contribution of wild birds (frugivores) in forest regeneration. Researchers compared the carbon storage potential that could be recovered in landscapes with limited fragmentation, with that of highly fragmented landscapes. Their data shows that highly fragmented landscapes restrict the movement of birds, thereby reducing the potential of carbon recovery by up to 38%.
Across the Atlantic Forest region in Brazil, the researchers found that it is critical to maintain a minimum of 40% forest cover. They also find that a distance of 133 meters (approximately 435 feet) or less between forested areas ensures that birds can continue to move throughout the landscape and facilitate ecological recovery.

Part 1

The study also found that different bird species have different impacts in terms of seed dispersal. Smaller birds disperse more seeds, but they can only spread small seeds from trees with lower carbon storage potential. In contrast, larger birds such as the Toco toucan or the Curl-crested jay disperse the seeds of trees with a higher carbon storage potential. The problem is that the larger birds are less likely to move across highly fragmented landscapes.
This crucial information enables us to pinpoint active restoration efforts—like tree planting—in landscapes falling below this forest cover threshold, where assisted restoration is most urgent and effective.
Allowing larger frugivores to move freely across forest landscapes is critical for healthy tropical forest recovery.
This study demonstrates that especially in tropical ecosystems seed dispersal mediated by birds, plays a fundamental role in determining the species that can regenerate.

Frugivores enhance potential carbon recovery in fragmented landscapes, Nature Climate Change (2024). DOI: 10.1038/s41558-024-01989-1

Evolution's recipe book: How 'copy paste' errors led to insect flight, octopus camouflage and human cognition

Seven hundred million years ago, a remarkable creature emerged for the first time. Though it may not have been much to look at by today's standards, the animal had a front and a back, a top and a bottom. This was a groundbreaking adaptation at the time, and one which laid down the basic body plan which most complex animals, including humans, would eventually inherit.

The inconspicuous animal resided in the ancient seas of Earth, likely crawling along the seafloor. This was the last common ancestor of bilaterians, a vast supergroup of animals including vertebrates (fish, amphibians, reptiles, birds, and mammals), and invertebrates (insects, arthropods, mollusks, worms, echinoderms and many more).

To this day, more than 7,000 groups of genes can be traced back to the last common ancestor of bilaterians, according to a study of 20 different bilaterian species including humans, sharks, mayflies, centipedes and octopuses. The findings were made by researchers at the Centre for Genomic Regulation (CRG) in Barcelona and are published today in the journal Nature Ecology & Evolution.

Remarkably, the study found that around half of these ancestral genes have since been repurposed by animals for use in specific parts of the body, particularly in the brain and reproductive tissues. The findings are surprising because ancient, conserved genes usually have fundamental, important jobs that are needed in many parts of the body.

When the researchers took a closer look, they found a series of serendipitous "copy paste" errors during bilaterian evolution were to blame. For example, there was a significant moment early in the history of vertebrates. A bunch of tissue-specific genes first appeared coinciding with two whole genome duplication events.

Animals could keep one copy for fundamental functions, while the second copy could be used as raw material for evolutionary innovation. Events like these, at varying degrees of scale, occurred constantly throughout the bilaterian evolutionary tree.

The authors of the study found many examples of new, tissue-specific functions made possible by the specialization of these ancestral genes.

The specialization of ancestral genes also laid some foundations for the development of complex nervous systems

Evolution of tissue-specific expression of ancestral genes across vertebrates and insects, Nature Ecology & Evolution (2024). DOI: 10.1038/s41559-024-02398-5

Human muscle map reveals how we try to fight effects of aging at cellular and molecular levels

How muscle changes with aging and tries to fight its effects is now better understood at the cellular and molecular level with the first comprehensive atlas of aging muscles in humans.

Researchers applied single-cell technologies and advanced imaging to analyze human skeletal muscle samples from 17 individuals across the adult lifespan. By comparing the results, they shed new light on the many complex processes underlying age-related muscle changes.

The atlas, published April 15 in Nature Aging, uncovers new cell populations that may explain why some muscle fibres age faster than others. It also identifies compensatory mechanisms the muscles employ to combat aging.

The findings offer avenues for future therapies and interventions to improve muscle health and quality of life as we age.

This study is part of the international Human Cell Atlas initiative to map every cell type in the human body, to transform understanding of health and disease.

As we age, our muscles progressively weaken. This can affect our ability to perform everyday activities like standing up and walking. For some people, muscle loss worsens, leading to falls, immobility, a loss of autonomy and a condition called sarcopenia. The reasons why our muscles weaken over time have remained poorly understood till now.

Part 1

In this new study, scientists  used both single-cell and single-nucleus sequencing techniques along with advanced imaging to analyze human muscle samples from 17 individuals aged 20 to 75.

They discovered that genes controlling ribosomes, responsible for producing proteins, were less active in muscle stem cells from aged samples. This impairs the cells' ability to repair and regenerate muscle fibers as we age. Further, non-muscle cell populations within these skeletal muscle samples produced more of a pro-inflammatory molecule called CCL2, attracting immune cells to the muscle and exacerbating age-related muscle deterioration.

Age-related loss of a specific fast-twitch muscle fiber subtype, key for explosive muscle performance, was also observed. However, they discovered for the first time several compensatory mechanisms from the muscles appearing to make up for the loss. These included a shift in slow-twitch muscle fibers to express genes characteristic of the lost fast-twitch subtype, and increased regeneration of remaining fast-twitch fiber subtypes.

The researchers  also identified specialized nuclei populations within the muscle fibers that help rebuild the connections between nerves and muscles that decline with age. Knockout experiments in lab-grown human muscle cells by the team confirmed the importance of these nuclei in maintaining muscle function.

With these new insights into healthy skeletal muscle aging, researchers all over the world can now explore ways to combat inflammation, boost muscle regeneration, preserve nerve connectivity, and more. Discoveries from research like this have huge potential for developing therapeutic strategies that promote healthier aging for future generations.

 Human skeletal muscle aging atlas, Nature Aging (2024). DOI: 10.1038/s43587-024-00613-3

Part 2

Scientists observe mechanical waves in bacterial communities

A new study by researchers  has reported the emergence of mechanical spiral waves in bacterial matter.

Spiral waves are commonly seen in artificial and natural systems (such as the heart). These emerge from interactions of neighboring elements, such as cardiac cells in the case of the heart. These spiral waves can have varying effects, sometimes leading to life-threatening conditions like fibrillation in the heart.

The new study, published in Nature Physics, explores spiral waves in bacteria—something that has not been observed before. In particular, the researchers' focus was on the species Pseudomonas aeruginosa. These are commonly found in soil and water and are also known to colonize hospitals.

The research is a continuation of their previous work where the authors studied long-range material transport in bacterial communities via open fluid channels.

Part 1

These spiral waves as observed by the researchers in bacteria are an emergent phenomenon. Emergent phenomena are a crucial aspect of complex systems, which are systems where the interaction of individual entities leads to phenomena that otherwise can't be observed.

This means we need to understand what is happening at the level of each entity, which in this case is a Pseudomonas aeruginosa bacterium. These bacteria have pilus motors, which are the key to the spiral waves.

Pilus motors are molecular motors, which are attached to pili—thin, hair-like appendages present on the bacterial cell surface. These motors play an important role in various processes for the bacterium, such as movement and surface attachment.

The propagating spiral waves resulted from the coordinated activity of the pilus motor, a grappling-hook-like motile organelle found in many bacterial species.

The mechanical movements of the pilus motors in many bacteria result in these spiral waves, which are like ripples on the bacterial surface.

The researchers found that the spiral waves resulted from the coordinated activity of pilus motors. They also observed that the waves were self-sustaining and stable, with nearly stationary spiral cores.

This stability is a characteristic shared by certain types of electrical and chemical spiral waves found in other living systems. However, the spiral waves observed in the bacteria are distinct from the other spiral waves.

Part 2

The findings shed light on bacterial populations and behavior, such as the formation of biofilms.

When bacteria adhere to a surface, it does so by producing extracellular polymeric substances (EPS). This substance forms a structured community known as biofilm, such that the bacteria is embedded in a matrix of EPS, protecting the bacteria from environmental stresses like antibiotics and host immune responses.

This entire process, known as the formation of biofilms, is essential for the survival of bacterial colonies. The opposite of this phenomenon—dispersal—is equally important.

When bacteria within a biofilm detach and spread to new locations, it is known as dispersal. Dispersal can occur in response to environmental cues, nutrient availability, or as part of the life cycle of the bacteria.

This mechanism can help bacteria colonize new surfaces or host environments and can influence the spread of infectious diseases or the formation of microbial communities in various ecosystems.

Part 3

The researchers think that the pilus motors not only serve as mechanical actuators but also as sensors. This means that they can detect mechanical stimuli in the environment in the environment, which allows for synchronized movements within bacterial populations.

Shiqi Liu et al, Emergence of large-scale mechanical spiral waves in bacterial living matter, Nature Physics (2024). DOI: 10.1038/s41567-024-02457-5

Part 4

In search for alien life, purple may be the new green

From house plants and gardens to fields and forests, green is the color we most associate with surface life on Earth, where conditions favored the evolution of organisms that perform oxygen-producing photosynthesis using the green pigment chlorophyll a.

But an Earth-like planet orbiting another star might look very different, potentially covered by bacteria that receive little or no visible light or oxygen, as in some environments on Earth, and instead use invisible infrared radiation to power photosynthesis.

Instead of green, many such bacteria on Earth contain purple pigments, and purple worlds on which they are dominant would produce a distinctive "light fingerprint" detectable by next-generation ground- and space-based telescopes, scientists report in new research.

Purple bacteria can thrive under a wide range of conditions, making it one of the primary contenders for life that could dominate a variety of worlds.

This is the gist of the paper titled "Purple is the New Green: Biopigments and Spectra of Earth-like Purple Worlds," published in Monthly Notices of the Royal Astronomical Society.

So we need to create a database for signs of life to make sure our telescopes don't miss life if it happens not to look exactly like what we encounter around us every day, the researchers say.

Purple bacteria can survive and thrive under such a variety of conditions that it is easy to imagine that on many different worlds, purple may just be the new green.

Lígia Fonseca Coelho et al, Purple is the new green: biopigments and spectra of Earth-like purple worlds, Monthly Notices of the Royal Astronomical Society (2024). DOI: 10.1093/mnras/stae601

Can animals count? Neuroscientists identify a sense of numeracy among rodents

A discovery that appears to confirm the existence of discrete number sense in rats has been announced by a joint research team from City University of Hong Kong (CityUHK) and The Chinese University of Hong Kong (CUHK).

The findings offer a crucial animal model for investigating the neural basis of numerical ability and disability in humans, the Hong Kong-based researchers say.

This innovative study deployed a numerical learning task, brain manipulation techniques and AI modeling to tackle an ongoing debate about whether rats can count.

Their study, published in Science Advances, sheds light on the mechanisms underlying numerical ability, a cognitive ability fundamental to mathematical aptitude, which is a hallmark of human intelligence. The article is titled "Disparate processing of numerosity and associated continuous magnit...".

The team found that rats without any previous knowledge of numbers could develop a sense of numbers when trained with sounds representing two or three numbers. Despite the influence of continuous magnitudes, the rats consistently focused on the number of sounds when making choices for food rewards.

In addition, the study helps dissect the relationship between magnitude and numerosity processing.

The researchers discovered that when they blocked a specific part of the rats' brains, called the posterior parietal cortex, the rats' ability to understand numbers was affected but not their sense of magnitude. "This suggests that the brain has a specific area for dealing with numbers".

The study not only solves a long-standing mystery about how brains handle numbers but also offers new insights into studying the specific neural circuits involved in number processing in animals and how genes are associated with mathematical ability. The findings from neural network modeling could have practical applications in the field of AI.

Tuo Liang et al, Disparate processing of numerosity and associated continuous magnitudes in rats, Science Advances (2024). DOI: 10.1126/sciadv.adj2566

Biodiversity is key to the mental health benefits of nature, new study finds

New research has found that spaces with a diverse range of natural features are associated with stronger improvements in our mental well-being compared to spaces with less natural diversity.

Published in Scientific Reports, this citizen science study used the smartphone application Urban Mind to collect real-time reports on mental well-being and natural diversity from nearly 2,000 participants.

Researchers found that environments with a larger number of natural features, such as trees, birds, plants and waterways, were associated with greater mental well-being than environments with fewer features, and that these benefits can last for up to eight hours.

Further analysis found that nearly a quarter of the positive impact of nature on mental health could be explained by the diversity of features present. These findings highlight that policies and practices that support richness of nature and species are beneficial both for environment and for public mental health.

Smartphone-based ecological momentary assessment reveals an incremental association between natural diversity and mental wellbeing', Scientific Reports (2024). DOI: 10.1038/s41598-024-55940-7

A single atom layer of gold—researchers create goldene

For the first time, scientists have managed to create sheets of gold only a single atom layer thick. The material has been termed goldene. According to researchers , this has given the gold new properties that can make it suitable for use in applications such as carbon dioxide conversion, hydrogen production, and production of value-added chemicals. Their findings are published in the journal Nature Synthesis.

Scientists have long tried to make single-atom-thick sheets of gold but failed because the metal's tendency to lump together.

But researchers  have now succeeded thanks to a hundred-year-old method used by Japanese smiths.

If you make a material extremely thin, something extraordinary happens—as with graphene. The same thing happens with gold. As you know, gold is usually a metal, but if single-atom-layer thick, the gold can become a semiconductor instead.

To create goldene, the researchers used a three-dimensional base material where gold is embedded between layers of titanium and carbon. But coming up with goldene proved to be a challenge. According to the researchers,  part of the progress is due to serendipity.

They had created the base material with completely different applications in mind. They started with an electrically conductive ceramics called titanium silicon carbide, where silicon is in thin layers. Then the idea was to coat the material with gold to make a contact. But when they exposed the component to high temperature, the silicon layer was replaced by gold inside the base material.

This phenomenon is called intercalation and what the researchers had discovered was titanium gold carbide. For several years, the researchers have had titanium gold carbide without knowing how the gold can be exfoliated or panned out.

Then the researchers found a method that has been used in Japanese forging art for over a hundred years. It is called Murakami's reagent, which etches away carbon residue and changes the color of steel in knife making, for example. But it was not possible to use the exact same recipe as the smiths did. Scientists had to look at modifications.

Part 1

They tried different concentrations of Murakami's reagent and different time spans for etching. One day, one week, one month, several months. What they noticed was that the lower the concentration and the longer the etching process, the better. But it still wasn't enough.

The etching must also be carried out in the dark as cyanide develops in the reaction when it is struck by light, and it dissolves gold. The last step was to get the gold sheets stable. To prevent the exposed two-dimensional sheets from curling up, a surfactant was added. In this case, a long molecule that separates and stabilizes the sheets, i.e. a tenside.

The goldene sheets are in a solution, a bit like cornflakes in milk. Using a type of 'sieve,' the researchers can collect the gold and examine it using an electron microscope to confirm that they have succeeded. Which they have!

The new properties of goldene are due to the fact that the gold has two free bonds when two-dimensional. Thanks to this, future applications could include carbon dioxide conversion, hydrogen-generating catalysis, selective production of value-added chemicals, hydrogen production, water purification, communication, and much more. Moreover, the amount of gold used in applications today can be much reduced.

Synthesis of goldene comprising single-atom layer gold, Nature Synthesis (2024). DOI: 10.1038/s44160-024-00518-4

Part 2

Scientists develop nanosilver-impregnated silk suture against surgical site infection

In recent years, the adherence of microorganisms to surfaces or coatings has created major health risks to humans. Among these, microbial attachment and growth on surgical suture lines accounts for more than 20% of health-related infections in patients.

As a result, extensive research has been conducted to develop strategies for preventing or reducing the formation of bacterial or fungal colonies on sutures.

Nanosilver has gained significant attention among researchers due to its long-known antimicrobial properties. Its optical and structural characteristics make it an appealing candidate for biomedical applications.

It can be synthesized using both green and chemical methods, although it typically carries a negative charge, which can compromise its stability and storage capabilities.

The biological impact of this synthesis was recently published in ACS Omega, where its effectiveness in coating silk sutures and inhibiting the growth of microorganisms was detailed by the research team.

Diego Antonio Monroy Caltzonci et al, Antimicrobial and Cytotoxic Effect of Positively Charged Nanosilver-Coated Silk Sutures, ACS Omega (2024). DOI: 10.1021/acsomega.4c01257

Quantum electronics: Charge travels like light in bilayer graphene

An international research team has demonstrated experimentally that electrons in naturally occurring double-layer graphene move like particles without any mass, in the same way that light travels. Furthermore, they have shown that the current can be "switched" on and off, which has potential for developing tiny, energy-efficient transistors—like the light switch in your house but at a nanoscale.

Graphene was identified in 2004 and is a single layer of carbon atoms. Among its many unusual properties, graphene is known for its extraordinarily high electrical conductivity due to the high and constant velocity of electrons traveling through this material. This unique feature has made scientists dream of using graphene for much faster and more energy-efficient transistors.

The challenge has been that to make a transistor, the material needs to be controlled to have a highly insulating state in addition to its highly conductive state. In graphene, however, such a "switch" in the speed of the carrier cannot be easily achieved. In fact, graphene usually has no insulating state, which has limited graphene's potential a transistor.

A research team has now found that two graphene layers, as found in the naturally occurring form of double-layer graphene, combine the best of both worlds: a structure that supports the amazingly fast motion of electrons moving like light as if they had no mass, in addition to an insulating state. The researchers showed that this condition can be changed by the application of an electric field applied perpendicularly to the material, making the double-layer graphene insulating.

This property of fast-moving electrons had been theoretically predicted as early as 2009, but it took significantly enhanced sample quality as enabled my materials supplied by NIMS and close collaboration about theory with MIT, before it was possible to identify this experimentally. While these experiments were carried out at cryogenic temperatures—at around 273° below freezing—they show the potential of bilayer graphene to make highly efficient transistors.

 Anna M. Seiler et al, Probing the tunable multi-cone band structure in Bernal bilayer graphene, Nature Communications (2024). DOI: 10.1038/s41467-024-47342-0

Pigeons are on par with primates in their numerical abilities, according to new University of Otago research appearing in the leading international journal Science.

The Department of Psychology researchers showed that pigeons can compare pairs of images picturing up to nine objects and order them by the lower to higher number with a success rate above chance.

“Pigeons on par with primates in numerical competence,” by Damian Scarf, Harlene Hayne, Michael Colombo. 23 December 2011, Vol 334, Science DOI: 10.1126/science.1213357

https://phys.org/news/2011-12-monkeys-pigeons.html#:~:text=(PhysOrg.com)%20%2D%2D%20Pigeons,the%20leading%20international%20journal%20Science.

Study reveals how humanity could unite to address global challenges

New research has found that perceptions of globally shared life experiences and globally shared biology can strengthen psychological bonding with humanity at large, which can motivate prosocial action on a global scale and help to tackle global problems. The findings have been published recently in Royal Society Open Science.

Many of the most daunting challenges facing humankind today—from the climate crisis and poverty to food insecurity and terrorism—can only be overcome through cooperation and collective action on a global scale. But what would it take to unite humanity in this way?

According to the results of a new study, the key could lie in two of the most potent drivers of social bonding known in group psychology—shared ancestry and shared transformative experiences—albeit shared not only on the level of the tribe, the nation, or the religious community, but with humanity at large.

Us-vs-them thinking is on the rise in many places all over the world, exacerbating conflicts and complicating finding solutions for pressing global problems. This new research, however, suggests that it is possible to foster a shared global identity which could facilitate cooperation on the global level. The practical implications of our findings for policymakers, NGOs, politicians, and activists are wide-ranging.

In two studies involving more than a thousand US participants in total, the researchers investigated whether shared biology and shared experiences with people across the world can foster bonding with humanity at large and motivate prosocial action on a global scale.

Part 1

To explore whether appeals to our globally shared biology can affect bonding with humanity at large, the study participants watched a TED Talk delivered by journalist A. J. Jacobs explaining how all humans share a common ancestry, portraying us as one large human family.

Those who watched the video expressed significantly stronger psychological bonds with humanity at large compared with a control group whose attitudes were measured before rather than after they had watched the video. Furthermore, participants who watched the video felt stronger social bonds with individuals supporting an opposing political party, compared with the control group.

To investigate whether globally shared experiences can strengthen social bonds on a global scale, the study focused on the common experience of motherhood. The researchers recruited a sample of mothers and showed that mothers felt stronger bonds with other women from all over the world if they shared motherhood experiences with them.

In each case, the strength of social bonds was measured using a series of images of two overlapping circles—one representing the participant and the other one a group, e.g. humanity at large or the group of all the world's mothers. The images differed in the degree of overlap between the two circles. Participants had to choose the image that best represented their relationship with the group, with the images that had the greatest amount of overlap representing the strongest social bonds with the group.

In both studies, the reported psychological bonding on a global scale was strongly reflected in measures of prosocial action. To assess this, the researchers used a measure from behavioral economics, where participants had to indicate how they would split an amount of money between members of two different groups in hypothetical scenarios. This measure is used as a practical and cost-efficient tool in experiments to shed light on how strongly participants care about different groups and has been shown to predict real-stakes behaviour very accurately.
Remembering that we are all related and all experience many of the same challenges in life could be the key to addressing a wide range of global problems, from intergroup conflicts to extreme poverty and the climate crisis, conclude teh researchers.

Why Care for Humanity?, Royal Society Open Science (2024). DOI: 10.1098/rsos.231632. royalsocietypublishing.org/doi/10.1098/rsos.231632

Part 2

Scientists discover how soil microbes survive in harsh desert environments

Prolonged droughts followed by sudden bursts of rainfall—how do desert soil bacteria manage to survive such harsh conditions? This long-debated question has now been answered by an ERC project led by a microbiologist Dagmar Woebken from the Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna.

The study reveals that desert soil bacteria are highly adapted to survive the rapid environmental changes experienced with each rainfall event. These findings were recently published in the journal Nature Communications.

Drylands cover over 46% of global land area and are expanding, not only due to climate change but also unsustainable land management practices. While plants are seldom encountered in deserts, invisible life thrives belowground. Microorganisms located in the so-called biocrust (the top millimeters to centimeter of the desert soil) enrich the soil with carbon and nitrogen, and also help prevent soil erosion and retain water. But these microbes live in a challenging environment, facing long periods of drought with infrequent rain.
Until now, it was unclear how they could maintain important ecosystem functions under such conditions. Using state-of-the-art methods in microbial ecology, Dagmar Woebken's team gained insights into microbial life in these soils.

Desert soil bacteria endure long drought periods in a state of dormancy, but are reactivated in response to rainfall events, which are short and very rare. The researchers uncovered a kind of "all-in" reactivation strategy in the biocrusts of the Negev Desert, Israel. The bacteria make the most of rainfall events—within this narrow window of activity, almost all microbial soil diversity (as well as individual cells) become active.

When scientists simulated a rainfall event in the laboratory, they observed that within the first 15 to 30 minutes, almost all taxonomic groups switched from a resting mode to an active mode. This is a remarkable characteristic of desert soil bacteria, as in other types of soil many groups of bacteria take much longer to reactivate. When reactivated, the bacteria would quickly begin to generate energy and repair their genomes.
In the study, the researchers simulated rainfall events with stable isotope labeled water—water containing heavy hydrogen. Using NanoSIMS, they examined individual cells to see which of them had incorporated the heavy hydrogen atoms.

With this approach, researchers can reveal the fraction of biocrust cells that reactivate in a rain event. We can also infer if they can grow in short rain events that in arid deserts often only last 1 to 2 days.
They found that almost all biocrust cells reactivate, but that in these short rain events only a small proportion of the cells would be able to double. A large proportion of the biocrust cells can therefore use rain events to regenerate and prepare for the next drought, but cell division does not occur.
These data help scientists understand how biocrust bacteria make optimal use of the short activity windows they experience in deserts. They are ideally adapted to withstand short-term changes in soil water content, a very stressful situation for the cells. This allows them to survive the sudden increase in water content during rain, as well as the subsequent drying out.
Additionally, the diverse microbial community is capable of immediate reactivation, which is of great benefit when it must return to a dormant state within a few hours to days.
The findings of this study are relevant not only for desert areas but also for other regions. The ability to survive water limitation will become increasingly important for soil microorganisms in temperate regions, as the frequency and intensity of droughts are increasing due to climate change. Insights gained from desert soil research can help to understand which features make soil microorganisms successful in surviving these challenges.

Survival and rapid resuscitation permit limited productivity in desert microbial communities, Nature Communications (2024). DOI: 10.1038/s41467-024-46920-6

Part 2

Amazon butterflies show how new species can evolve from hybridization

If evolution was originally depicted as a tree, with different species branching off as new blooms, then new research shows how the branches may actually be more entangled. In "Hybrid speciation driven by multilocus introgression of ecological traits," published in Nature,  researchers show that hybrids between species of butterflies can produce new species that are genetically distinct from both parent species and their earlier forebears.

Writing to Charles Darwin in 1861, naturalist Henry Walter Bates described brightly colored Heliconius butterflies of the Amazon as "a glimpse into the laboratory where Nature manufactures her new species." More than 160 years later, an international team of researchers led by biologists Neil Rosser, Fernando Seixas, James Mallet, and Kanchon Dasmahapatra also focused on Heliconius to document the evolution of a new species.
Using whole-genome sequencing, the researchers have shown that a hybridization event some 180,000 years ago between Heliconius melpomene and the ancestor of today's Heliconius pardalinus produced a third hybrid species, Heliconius elevatus. Although descended from hybrids, H. elevatus is a distinct butterfly species with its own individual traits, including its caterpillar's host plant and the adult's male sex pheromones, color pattern, wing shape, flight, and mate choice. All three species now fly together across a vast area of the Amazon rainforest.

Part 1

Historically hybridization was thought of as a bad thing that was not particularly important when it came to evolution. But what genomic data have shown is that actually hybridization among species is widespread.
The implications may alter how we view species. A lot of species are not intact units. They're quite leaky, and they're exchanging genetic material.
So the species that are evolving are constantly exchanging genes, and the consequence of this is that it can actually trigger the evolution of completely new lineages.
Normally, species are thought to be reproductively isolated. They can't produce hybrids that are reproductively fertile. While there is now evidence of hybridization between species, what was difficult to confirm was that this hybridization is, in some way, involved in speciation. The question is: How can you collapse two species together and get a third species out of that collapse.

The new research provides a next step in understanding how hybridization and speciation work. Over the last 10 or 15 years, there's been a paradigm shift in terms of the importance of hybridization and evolution.
This research has the potential to play a role in the current biodiversity crisis. Understanding something as basic as "what we mean by a species is important for saving species and for conservation," particularly in the Amazon.
In addition, such work may prove useful in understanding carriers of disease. Multiple species of mosquito, for example, can carry malaria. Although these mosquitos are closely related, almost nothing is known about how they interact, and whether they hybridize with each other.

Neil Rosser, Hybrid speciation driven by multilocus introgression of ecological traits, Nature (2024). DOI: 10.1038/s41586-024-07263-w. www.nature.com/articles/s41586-024-07263-w

Part 2

Researchers identify a group of cells involved in working memory

Investigators have discovered how brain cells responsible for working memory—the type required to remember a phone number long enough to dial it—coordinate intentional focus and short-term storage of information. The study detailing their discovery was published in Nature.

They have identified for the first time a group of neurons, influenced by two types of brain waves, that coordinate cognitive control and the storage of sensory information in working memory. These neurons don't contain or store information, but are crucial to the storage of short-term memories.

Working memory, which requires the brain to store information for only seconds, is fragile and requires continued focus to be maintained. In disorders such as Alzheimer's disease or attention-deficit hyperactivity disorder, it is often not memory storage, but rather the ability to focus on and retain a memory once it is formed that is the problem,

Understanding the control aspect of working memory will be fundamental for developing new treatments for these and other neurological conditions.
Part 1

**

To explore how working memory functions, investigators recorded the brain activity of 36 hospitalized patients who had electrodes surgically implanted in their brains as part of a procedure to diagnose epilepsy. The team recorded the activity of individual brain cells and brain waves while the patients performed a task that required use of working memory.

On a computer screen, patients were shown either a single photo or a series of three photos of various people, animals, objects or landscapes. Next, the screen went blank for just under three seconds, requiring patients to remember the photos they just saw. They were then shown another photo and asked to decide whether it was the one (or one of the three) they had seen before.

When patients performing the working memory task were able to respond quickly and accurately, investigators noted the firing of two groups of neurons: "category" neurons that fire in response to one of the categories shown in the photos, such as animals, and "phase-amplitude coupling," or PAC, neurons.

PAC neurons, newly identified in this study, don't hold any content, but use a process called phase-amplitude coupling to ensure the category neurons focus and store the content they have acquired.

PAC neurons fire in time with the brain's theta waves, which are associated with focus and control, as well as to gamma waves, which are linked to information processing. This allows them to coordinate their activity with category neurons, which also fire in time to the brain's gamma waves, enhancing patients' ability to recall information stored in working memory.

Imagine when the patient sees a photo of a cat, their category neurons start firing 'cat, cat,cat, cat' while the PAC neurons are firing 'focus/remember'.
Through phase-amplitude coupling, the two groups of neurons create a harmony superimposing their messages, resulting in 'remember cat.' It is a situation where the whole is greater than the sum of its parts, like hearing the musicians in an orchestra play together. The conductor, much like the PAC neurons, coordinates the various players to act in harmony.

PAC neurons do this work in the hippocampus, a part of the brain that has long been known to be important for long-term memory. This study offers the first confirmation that the hippocampus also plays a role in controlling working memory.

Ueli Rutishauser, Control of working memory by phase–amplitude coupling of human hippocampal neurons, Nature (2024). DOI: 10.1038/s41586-024-07309-z. www.nature.com/articles/s41586-024-07309-z

Part 2

Sink to source: Does what we put into our plumbing end up back in the water supply?

When you see an advertisement for a detergent promising to brighten your clothes, something called a fluorescent whitening compound, or optical brightener, is probably involved. Such material absorbs UV light and emits visible blue light via fluorescence. The result? Brighter whites, vibrant colors. Yes, your clothes are glowing.

However, these brighteners can make their way into the water supply!

 When limestone and dolomite dissolve, they can form spectacular caves and sinkholes characteristic of a karst terrain. Karst aquifers can also feature interconnected fractures that create conduits that channel water. These aquifers are a major source of drinking water around the world. Unfortunately, they're also exceptionally vulnerable to pollution. Features that connect Earth's surface directly with an aquifer can funnel pollutants into water supplies.

Researchers have detected high concentrations of fluorescent whitening compounds and microplastics in these waters.

 When fluorescent whitening compounds, which definitely come from humans, and microplastics rise and fall together in water samples, that covariation indicates that microplastic contamination is probably coming from wastewater. Indeed, this is the first study to show such a link in samples from karst springs.

Luka Vucinic et al, Understanding the impacts of human wastewater effluent pollution on karst springs using chemical contamination fingerprinting techniques, EGU General Assembly (2024). DOI: 10.5194/egusphere-egu24-11063

Scientists Discover How Tardigrades Survive Blasts of Radiation

Tardigrades are possibly the most indestructible animal on Earth. These microscopic little beasties can take almost anything humans throw at them, and waddle away perfectly intact.

 

The strategies behind these feats of superheroic survival are multiple, from a damage suppressor protein that literally protects their DNA, to a dehydrated, suspended animation 'tun' state that they can enter when external conditions get untenable.

And now, scientists have uncovered a new one. They're able to turn up the dial on damage repair to 11.

They blasted tardigrades with gamma rays, and watched to see how they responded.

We've known about tardigrades' fascinating resistance to ionizing radiation for decades. They can survive around 1,000 times the dose that would be lethal to humans, and continue going about their tiny lives as though it were nothing.

The damage suppression protein, Dsup, is thought to play a role in this for some tardigrades, but not all tardigrade species have Dsup or a homolog thereof, suggesting that there is some other means of survival at play.

Part 1

To figure it out, the researchers investigated the effect of gamma radiation on a species of tardigrade called Hypsibius exemplaris. They placed tardigrades in a benchtop irradiator that exposed the critters to gamma rays emitted by the beta decay of cesium-137. Since the amount of radiation is known, they were able to expose the tardigrades to specific doses – one lower dose that is within tolerable levels, and a much higher median lethal dose.

To their surprise, although H. exemplaris does have Dsup, the radiation exposure didn't seem to trigger it. In fact, the tardigrades' DNA took a pretty big whack of radiation damage.

Rather than prophylactic protection, the tardigrades ramped up production of DNA repair genes to such a degree that their products became some of the most abundant in their microscopic bodies. By 24 hours after radiation exposure, the tardigrades had repaired most of the DNA broken by ionizing radiation.
In a follow-up, the researchers expressed some of the tardigrade repair genes in a culture of Escherichia coli, and exposed samples of the bacterium to ionizing radiation. Bacteria that had been inoculated with tardigrade genes showed a similar DNA repair ability to that seen in H. exemplaris, but not seen in untreated E. coli.
This suggests, the researchers found, that H. exemplaris is able to sense ionizing radiation, and mount a response that allows it to survive doses that would obliterate other animals.

These animals are mounting an incredible response to radiation, and that seems to be a secret to their extreme survival abilities.

https://www.cell.com/current-biology/abstract/S0960-9822(24)00316-6

Scientists uncover 95 regions of the genome linked to PTSD

In post-traumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person's quality of life. About 6% of people who experience trauma develop the disorder, but scientists don't yet understand the neurobiology underlying PTSD.

Now, a new genetic study of more than 1.2 million people has pinpointed 95 loci, or locations in the genome, that are associated with risk of developing PTSD, including 80 that had not been previously identified. The study, from the PTSD working group within the Psychiatric Genomics Consortium (PGC—PTSD) together with Cohen Veterans Bioscience, is the largest and most diverse of its kind, and also identified 43 genes that appear to have a role in causing PTSD. The work appears in Nature Genetics.

This discovery firmly validates that heritability is a central feature of PTSD based on the largest PTSD genetics study conducted to date and reinforces there is a genetic component that contributes to the complexity of PTSD.

The findings both confirm previously discovered genetic underpinnings of PTSD and provide many novel targets for future investigation that could lead to new prevention and treatment strategies.

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder, Nature Genetics (2024). DOI: 10.1038/s41588-024-01707-9

AI tool predicts responses to cancer therapy using information from each cell of the tumour

With more than 200 types of cancer and every cancer individually unique, ongoing efforts to develop precision oncology treatments remain daunting. Most of the focus has been on developing genetic sequencing assays or analyses to identify mutations in cancer driver genes, then trying to match treatments that may work against those mutations.

But many, if not most, cancer patients do not benefit from these early targeted therapies. In a new study published in the journal Nature Cancer, scientists describe a first-of-its-kind computational pipeline to systematically predict patient response to cancer drugs at single-cell resolution. 

Dubbed PERsonalized Single-Cell Expression-Based Planning for Treatments in Oncology, or PERCEPTION, the new artificial intelligence–based approach dives deeper into the utility of transcriptomics—the study of transcription factors, the messenger RNA molecules expressed by genes that carry and convert DNA information into action.

A tumor is a complex and evolving beast. Using single-cell resolution can allow us to tackle both of these challenges.

PERCEPTION allows for the use of rich information within single-cell omics to understand the clonal architecture of the tumor and monitor the emergence of resistance (In biology, omics refers to the sum of constituents within a cell).

The ability to monitor the emergence of resistance is the most exciting part for researchers. It has the potential to allow them to adapt to the evolution of cancer cells and even modify their treatment strategy.

PERCEPTION: Predicting patient treatment response and resistance via single-cell transcriptomics of their tumors, Nature Cancer (2024). DOI: 10.1038/s43018-024-00756-7

Discovery of new ancient giant snake in India

A new ancient species of snake dubbed Vasuki Indicus, which lived around 47 million years ago in the state of Gujarat in India, may have been one of the largest snakes to have ever lived, suggests new research published in Scientific Reports. The new species, which reached an estimated length of between 11 and 15 meters, was part of the now extinct madtsoiidae snake family, but represented a distinct lineage that originated in India.

Researchers describe a new specimen recovered from the Panandhro Lignite Mine, Kutch, Gujarat State, India, which dates to the Middle Eocene period, approximately 47 million years ago. The new species is named Vasuki indicus after the mythical snake round the neck of the Hindu deity Shiva and in reference to its country of discovery, India. The authors describe 27 mostly well-preserved vertebra, some of which are articulated, which appear to be from a fully-grown animal.

The vertebrae measure between 37.5 and 62.7 millimeters in length and 62.4 and 111.4 millimeters in width, suggesting a broad, cylindrical body. Extrapolating from this, the authors estimate that V. Indicus may have reached between 10.9 and 15.2 meters in length. This is comparable in size to the longest known snake to have ever lived, the extinct Titanoboa, although the authors highlight the uncertainty around these estimates. They further speculate that V. Indicus's large size made it a slow-moving, ambush predator akin to an anaconda.

The authors identify V. Indicus as belonging to the madtsoiidae family, which existed for around 100 million years from the Late Cretaceous to the Late Pleistocene and lived in a broad geographical range including Africa, Europe, and India. They suggest that V. Indicus represents a lineage of large madtsoiids that originated in the Indian subcontinent and spread via southern Europe to Africa during the Eocene, approximately 56 to 34 million years ago.

Debajit Datta, Largest known madtsoiid snake from warm Eocene period of India suggests intercontinental Gondwana dispersal, Scientific Reports (2024). DOI: 10.1038/s41598-024-58377-0. www.nature.com/articles/s41598-024-58377-0

Researchers crack mystery of swirling vortexes in egg cells

Egg cells are the largest single cells on the planet. Their size—often several to hundreds of times the size of a typical cell—allows them to grow into entire organisms, but it also makes it difficult to transport nutrients and other molecules around the cell. Scientists have long known that maturing egg cells, called oocytes, generate internal, twister-like fluid flows to transport nutrients, but how those flows arise in the first place has been a mystery.

Now, research led by computational scientists, has revealed that these flows—which look like microscopic tornados—arise organically from the interactions of a few cellular components.

Their work, published in Nature Physics, used theory, advanced computer modeling, and experiments with fruit fly egg cells to uncover the twisters' mechanics. The results are helping scientists better understand foundational questions about egg cell development and cellular transport.

In a typical human cell, it takes only 10 to 15 seconds for a typical protein molecule to meander from one side of the cell to the other via diffusion; in a small bacterial cell, this trip can happen in just a single second. But in the fruit fly egg cells studied here, diffusion alone would take an entire day—much too long for the cell to function properly. Instead, these egg cells have developed 'twister flows' that circle around the interior of the oocyte to distribute proteins and nutrients quickly, just as a tornado can pick up and move material much farther and quicker than wind alone. 

Sayantan Dutta et al, Self-organized intracellular twisters, Nature Physics (2024). DOI: 10.1038/s41567-023-02372-1

Why zebrafish can regenerate damaged heart tissue, while other fish species cannot

A heart attack will leave a permanent scar on a human heart, yet other animals, including some fish and amphibians, can clear cardiac scar tissue and regrow damaged muscle as adults.

Scientists have sought to figure out how special power works in hopes of advancing medical treatments for human cardiac patients, but the great physiological differences between fish and mammals make such inquiries difficult.

So biologists tackled the problem by comparing two fish species: zebra fish, which can regenerate its heart, and medaka, which cannot.

By comparing these two fish that have similar heart morphology and live in similar habitats, researchers could have a better chance of actually finding what the main differences are.

They  identified a few possible explanations, mostly associated with the immune system, for how zebrafish fix cardiac tissue, according to research published in Biology Open.

Their study shed new light on the molecular and cellular mechanisms at play in zebrafish's heart regeneration. It told them these two hearts that look very similar are actually very different.

Both members of the teleost family of ray-finned fish, zebrafish (Danio rerio) and medaka (Oryzias latipes) descended from a common ancestor that lived millions of years ago. Both are about 1.5 inches long, inhabit freshwater and are equipped with two-chamber hearts. Medaka are native to Japan and zebrafish are native to the Ganges River basin.

According to the study, the existence of non-regenerating fish presents an opportunity to contrast the differing responses to injury to identify the cellular features unique to regenerating species. The research team suspect heart regeneration is an ancestral trait common to all teleosts.

Understanding the evolutionary path that led to the loss of this ability in some teleost species could offer parallel insights into why mammals cannot regenerate as adults.

part 1

To conduct their experiments, the  researchers used a device called a cryoprobe to injure the fish hearts in ways that mimic heart attacks in humans, then extracted the hearts after certain time frames to learn how the two species responded differently.

They found that Zebrafish have this immune response that is typical of what you might see during a viral infection, called an interferon response. That response is completely absent in medaka.

The study documented differences in immune cell recruitment and behavior, epicardial and endothelial cell signaling, and alterations in the structure and makeup of the heart. For example, medaka lack a certain type of muscle cells that are present in zebrafish.

The study indicates the zebrafish's ability to regenerate has something to do with its immune system, but understanding exactly how would take more research. For example, far more macrophages, specialized immune cells, migrated into the wound site in zebrafish than in medaka.

Unlike medaka, the zebrafish form a transient scar that doesn't calcify into rigid tissue.

What you do with that scar is what matters. Researchers think that the interferon response causes these specialized macrophage cells to come into that wound site and start to promote the growth of new blood vessels.

Over time new muscle replaces the damaged cardiac tissue and the heart heals.

The scientists' hope is that they build this knowledge base in animals that are really accessible and can be studied in incredible detail, then use that knowledge to generate more focused experiments in mammals, and then maybe someday in human patients.

Clayton M. Carey et al, Distinct features of the regenerating heart uncovered through comparative single-cell profiling, Biology Open (2024). DOI: 10.1242/bio.060156

Part 2

Keys, wallet, phone: the neuroscience behind working memory

Working memory is a fundamental process that allows us to temporarily store important information, such as the name of a person we’ve just met. However distractions can easily interrupt this process, leading to these memories vanishing. By looking at the brain activity of people doing working-memory tasks, a team have now confirmed that working memory requires two brain regions: one to hold a memory as long as you focus on it; and another to control its maintenance by helping you to not get distracted.

Some Microbes Are Tiny 'Vampires' With a Deadly Attraction to Human Blood
Researchers have discovered what they describe as 'bacterial vampirism', identifying particular types of bacteria that are attracted to human blood – an attraction that can lead to fatal infections.
Researchers outline how these deadly bacteria are drawn to serum – the liquid part of our blood – because of the nutrients and energy it provides.

That can be a particular problem for people with irritable bowel disease (IBD), where intestinal bleeding can offer gut bacteria a route into the bloodstream. However, these findings also shed light on potential new treatment routes.
Bacteria infecting the bloodstream can be lethal. Some of the bacteria that most commonly cause bloodstream infections actually sense a chemical in human blood and swim toward it.
The researchers used a customized device for injecting tiny amounts of fluid and a high-powered microscope to analyze the interaction of bacteria and blood.

Strains of three bacteria known to cause fatal infections, belonging to the species Salmonella enterica, Escherichia coli, and Citrobacter koseri, were found to be attracted to the human serum.

What's more, the team identified some of the biological interactions: it looks as though the amino acid serine is one of the chemicals the bacteria can sense, seek out, and consume, via particular protein receptors.
Part 1

This response doesn't take long at all either. In the experiments run for the study, it took less than a minute for these types of bacteria to realize that blood was nearby and to head towards it.

"We show here that the bacterial attraction response to serum is robust and rapid," write the researchers in their published paper.

The types of bacteria investigated here, from the family Enterobacteriaceae, have already been linked to conditions such as gastrointestinal bleeding and sepsis, particularly where IBD is involved.
The thinking is that these bacteria are latching on to the internal bleeding that often comes with IBD, which is how fatalities can occur.
Knowing more about how bacteria sense the serum in blood, and make use of it, might eventually save lives if treatments are focused on this. By learning how these bacteria are able to detect sources of blood, in the future we could develop new drugs that block this ability.
Bacterial vampirism mediated through taxis to serum:

https://elifesciences.org/reviewed-preprints/93178v2

Researchers find lower grades given to students with surnames that come later in alphabetical order

Knowing your ABCs is essential to academic success, but having a last name starting with A, B or C might also help make the grade.

What's in a name? A lot!

An analysis by  researchers of more than 30 million grading records from U-M finds students with alphabetically lower-ranked names receive lower grades. This is due to sequential grading biases and the default order of students' submissions in Canvas—the most widely used online learning management system—which is based on the alphabetical rank of their surnames. What's more, they find, those alphabetically disadvantaged students receive comments that are notably more negative and less polite, and exhibit lower grading quality measured by post-grade complaints from students.

 Researchers suspect that fatigue is one of the major factors that is driving this effect, because when you're working on something for a long period of time, you get tired and then you start to lose your attention and your cognitive abilities  are dropping.

The researchers note the option exists to grade the assignments in a random order, and some educators do, but alphabetical order is the default mode in Canvas and other online learning management systems. One simple fix would be to make random order the default setting.

They also suggest academic institutions could hire more graders for larger classes, distribute the workload among more people or train them to be aware of and lessen the bias while grading.

The study is under review by the journal Management Science and currently available as a working paper.

part 1

Researchers find lower grades given to students with surnames that come later in alphabetical order

(This title is somewhat misleading, please read on to know why)

Knowing your ABCs is essential to academic success, but having a last name starting with A, B or C might also help make the grade.

What's in a name? A lot!

An analysis by researchers of more than 30 million grading records from U-M finds students with alphabetically lower-ranked names receive lower grades. This is due to sequential grading biases and the default order of students' submissions in Canvas—the most widely used online learning management system—which is based on the alphabetical rank of their surnames. What's more, they find, those alphabetically disadvantaged students receive comments that are notably more negative and less polite, and exhibit lower grading quality measured by post-grade complaints from students.

Part 2

Their research uncovered a clear pattern of a decline in grading quality as graders evaluate more assignments. According to Wang, students whose surnames start with A, B, C, D or E received a 0.3-point higher grade out of 100 possible points than compared to when they were graded randomly. Likewise, students with later-in-the-alphabet surnames received a 0.3-point lower grade—creating a 0.6-point gap.

A 0.6-point difference might seem small, but such a disparity did affect students' course grade-point averages, which negatively influences opportunities in their respective career paths.

The Researchers suspect that fatigue among the examiners is one of the major factors that is driving this effect, because when you're working on something for a long period of time, you get tired and then you start to lose your attention and your cognitive abilities are dropping.

The researchers note the option exists to grade the assignments in a random order, and some educators do, but alphabetical order is the default mode in Canvas and other online learning management systems. One simple fix would be to make random order the default setting.

They also suggest academic institutions could hire more graders for larger classes, distribute the workload among more people or train them to be aware of and lessen the bias while grading.

The study is under review by the journal Management Science and currently available as a working paper.

Part 3

(PS: Please take this work with a pinch of salt because we are waiting for reproduction of these results.

This is still under review and the point difference is small.

And, students, this is not an excuse for your laziness. Because this need not be the case every time you write your exams. Most of the time in my practical and viva part of exams I was the last person to submit my results and got interviewed but still got top ranks).

Zhihan (Helen) Wang et al, 30 Million Canvas Grading Records Reveal Widespread Sequential Bias and System-Induced Surname Initial Disparity (2023). On SSRN: ssrn.com/abstract=4603146

Part 4

Persistent questioning of knowledge takes a toll: New study supports theories that baseless discrediting harms

It can be demoralizing for a person to work in a climate of repetitive skepticism and doubt about what they know, a new study shows.

This is  not about healthy, well-founded skepticism. This is about failures-of-exchange when a person is persistently overlooked, unheard, brushed off and explained to. 

Why? Something about who the person is—their identity—suggests to their interlocuter that they couldn't possibly be right due to the interlocuter's bias. These biases take many forms: race or ethnicity, manner of speaking, weight, attractiveness, age, style and so on.

Researchers have theorized that baseless discrediting of what people with marginalized social identities know is a central driver of prejudice and discrimination.

They conducted experiments that backed up these theories, finding that people are emotionally invested in being treated as credible, even in anonymous games. Further, they found that emotional impact of discreditation varies based on gender, race and experience with racial discrimination. 

The authors think that hostility in intellectual arenas is an ethical issue.

Discrediting of a person as a legitimate knower can be subtle, which makes it difficult to isolate, and, therefore, understudied.

But growing research shows regular exposure to even relatively subtle prejudice and discrimination degrades physical and mental health, leading to outcomes like high blood pressure, chronic stress and depression.

Part 1

To deepen their understanding of the impact of epistemic injustice—injustice around the domain of knowledge—the researchers focused on the emotional consequences of feedback. They modeled epistemic injustice in the lab by creating an experiment to safely simulate everyday experiences of invalidation. Participants observed a game, then shared their knowledge about the game—either how it worked or how they felt about it.

The crucial part of the experiment came next; participants received feedback, supposedly from their partner in the game, about what they shared. Some feedback was validating, some was discrediting, and some was mildly insulting.

The participants then rated how positive or negative that feedback made them feel, the key measure of their emotional responses. The researchers combined the experiment with surveys of variables thought to factor into epistemic injustice—race, gender and experiences with race-based discrimination and trauma.

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The experiment conducted by researchers revealed an important generality about knowledge. People find it more emotionally taxing to have their understanding of facts questioned than to have their feelings questioned.

But more important findings came from the experiment outcomes combined with the surveys, which showed that race and gender factored into the experimental results.

These findings are consistent, with research on prejudice and discrimination showing that Black men experience more racial discrimination in areas where credibility is extremely important—such as employment, educational settings and interactions with law enforcement—but where credibility can be undermined by emotional responses.

Another consistent finding underscored the importance of individual differences. Validation—when participants were told that they were right—was significantly more positive for white women compared with white men, which resonates with studies showing that positive interventions boost women's academic performance.

Insights from this study could benefit managers, educators and people interested in living and working in safer and more just communities. For universities, we think the results highlight the world of emotional coping mechanisms spoken about too rarely, but always under the surface in intellectual spaces.

Laura Niemi et al, The emotional impact of baseless discrediting of knowledge: An empirical investigation of epistemic injustice, Acta Psychologica (2024). DOI: 10.1016/j.actpsy.2024.104157

Part 2

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