Science Simplified!

                       JAI VIGNAN

All about Science - to remove misconceptions and encourage scientific temper

Communicating science to the common people

'To make  them see the world differently through the beautiful lense of  science'

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  • Dr. Krishna Kumari Challa

    For decades, memory research focused on two brain regions: the hippocampus, home of short-term memory, and the cortex, which was thought to house long-term memories. The latter, scientists imagined, lie gated behind biological on-and-off switches.

    Existing models of memory in the brain involved transistor-like memory molecules that act as on/off switches

    In other words, in this model, if a short-term memory was tagged for long-term storage, it would remain so indefinitely. But, even as investigations in this vein led to numerous insights, researchers understood that this model was ultimately too simple—for instance, it didn't account for why some long-term memories last weeks while others last a lifetime.

    Then, in 2023, the same researchers published a paper that identified a brain pathway that links short- and long-term memories. An important component of which is a region in the center of the brain called the thalamus, which not only helps select which memories should be remembered, but routes them to the cortex for long-term stabilization.

    The findings set the stage for tackling some of the most fundamental questions in the field of memory research: What happens to memories beyond short-term storage in the hippocampus—and what molecular mechanisms are behind the sorting process that promotes important memories to the cortex and demotes unimportant ones to be forgotten?

    To answer these questions, the team developed a behavioral model using a virtual reality system where mice formed specific memories.

    The results suggest that long-term memory is not maintained by a single molecular on/off switch, but by a cascade of gene-regulating programs that unfold over time and across brain regions like a series of molecular timers.

    Initial timers turn on quickly and fade just as fast, allowing for rapid forgetting; later timers act more slowly but create more durable memories. This stepwise process allows the brain to promote important experiences for long-term storage, while others fade.

    In this study, the researchers used repetition as a proxy for importance, comparing memories of frequently repeated contexts to those encountered less often. The team identified three transcriptional regulators: Camta1 and Tcf4 in the thalamus, and Ash1l in the anterior cingulate cortex, which are not necessary for initially forming memories, but are crucial for maintaining them. Disrupting Camta1 and Tcf4 impaired functional connections between the thalamus and cortex, leading to memory loss.

    The model suggests that, after the basic memory is formed in the hippocampus, Camta1 and its targets ensure the initial persistence of the memory. With time, Tc4 and its targets are activated, providing cell adhesion and structural support to further maintain the memory. Finally, Ash1l recruits chromatin remodeling programs that make the memory more persistent.

    Unless you promote memories onto these timers, the researchers think you're primed to forget it quickly.

    Part2

  • Dr. Krishna Kumari Challa

    Interestingly, Ash1l belongs to a family of proteins called histone methyltransferases that retain memory in other biological systems as well. "In the immune system, these molecules help the body remember past infections; during development, those same molecules help cells remember that they've become a neuron or muscle and maintain that identity long-term. The brain may be repurposing these ubiquitous forms of cellular memory to support cognitive memories.

    The findings may have implications for memory-related diseases.

    By identifying the gene programs that preserve memory, researchers may eventually find ways to route memory through alternate circuits and around damaged parts of the brain in conditions such as Alzheimer's.

    If we know the second and third areas that are important for memory consolidation, and we have neurons dying in the first area, perhaps we can bypass the damaged region and let healthy parts of the brain take over.

    Part3

  • Dr. Krishna Kumari Challa

    Schizophrenia-spectrum disorders may originate in specific brain regions that show early structural damage
     

    Schizophrenia-spectrum disorders are linked to early structural damage in specific brain regions, particularly the temporal, cingulate, and insular lobes, with reduced morphological similarity indicating network disconnection. These changes are more pronounced in severe cases and correlate with altered neurobiology, including increased astrocytes, neurotransmitters, and reduced metabolism.

    Natalia García-San-Martín et al, Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia, Nature Communications (2025). DOI: 10.1038/s41467-025-63792-6

  • Dr. Krishna Kumari Challa

    Mini-fridges on a nanoscale? New cooling technique could make computer chips more powerful

    A new ion-based cooling method uses voltage-controlled nanopores in semiconductor membranes to drive selective ion flow, enabling localized heating or cooling at the nanoscale. This approach achieves temperature drops over 2 K and is compatible with current chip fabrication, offering improved thermal management and reduced environmental impact for advanced semiconductor devices.

    Makusu Tsutsui et al, Gate-Tunable Ionothermoelectric Cooling in a Solid-State Nanopore, ACS Nano (2025). DOI: 10.1021/acsnano.5c13339

  • Dr. Krishna Kumari Challa

    Persistent environmental toxins already accumulate in animal tissues during the fetal stage, research finds

    Persistent organic pollutants (POPs) begin to accumulate in the tissues of mammals already during the fetal stage, according to new research.
      The animal-model study found that environmental toxins had built up in the tissues of sheep raised in clean organic production, and that the same substances were transferred in notable amounts to the developing fetuses' adipose tissue. 

    Persistent environmental toxins, such as PCBs and DDT, remain in nature for long periods without breaking down. They can accumulate in the fatty tissues of organisms and bioaccumulate through the food chain. These substances were previously used in industry and as insecticides, and although their use is now strictly regulated, they remain widespread in the environment.

    A study appearing in Environmental Research analyzed tissue samples from 15 organic ewes and their lambs shortly after birth, searching for the most common POPs.

    Almost all of the substances investigated were detected in both adult sheep and lamb tissues. All the compounds identified were able to cross the placenta, and the transfer was so effective that concentrations in the lambs' tissues averaged 30–103% of those measured in the mothers. 

    Because placental structure in sheep differs from that in humans, no direct conclusions can be drawn regarding human exposure. However, concentrations of POPs in adult human adipose tissue are on average higher than in sheep, underscoring the need for further research. 

    In epidemiological studies, POP concentrations measured from umbilical cord blood after birth have been linked to obesity, metabolic syndrome and lower IQ 

    Ella Vuoti et al, Adipose tissue deposition and placental transfer of persistent organic pollutants in ewes, Environmental Research (2025). DOI: 10.1016/j.envres.2025.123164

  • Dr. Krishna Kumari Challa

    Flashy feathers may put some male pheasant species' lives at risk

    The male Lady Amherst's pheasant knows how to put on a show when it comes to attracting mates. As well as elaborate courtship displays, they will unfurl their golden feathers to form a cape around their neck, which can prove irresistible to some females of the species. 

    However, according to new research published in the journal Biology Letters, this spectacular ornamentation comes at a potentially life-threatening cost. It can severely restrict their field of vision, making them more vulnerable to predators.

    As with most animals, vision is critical for birds, helping them forage for food, spot lurking predators, and keep an eye on rivals. For years, scientists understood that a bird's vision was largely shaped by its ecology (where it lives, what it eats, and how it forages) rather than its gender. But this research is the first to show that male and female birds see the world differently.

    The study authors used a technique called ophthalmoscopic reflex to map the bird's visual field. This involves shining a light into a bird's eye and mapping where the reflection disappears, which marks the edge of its field of vision.

    The team studied four captive Lady Amherst's pheasants and three golden pheasants (males of this species also have a colorful cape of feathers).

    They found that males have a 30 to 40-degree smaller vertical range of binocular vision, which means they can't see as well above and in front of their heads. The researchers also discovered that males have a blind spot that is much larger than females, measuring over 114 square centimeters compared to about 21 square centimeters. The blind spot behind their head was also wider than that of females by about 10 degrees.

    Part1

  • Dr. Krishna Kumari Challa

    To confirm feathers were the cause, the scientists also studied two related pheasant species that lack elaborate head plumage. In these birds, male and female fields of vision were identical. 

    According to the researchers, the enlarged blind area of the Lady Amherst's and golden pheasant males leaves them more vulnerable to predation than females. This visual cost is the latest example of the handicap principle, an evolutionary idea that suggests that if a male can survive despite carrying a feature that puts it at a disadvantage, it must have superior genes.

    "The reduced visual field in males compared to females in these pheasants, as a result of feather ornamentation, could be viewed as a relative handicap," wrote the researchers in their paper.

    Alexandra E. R. Lamond et al, The visual impediment of cranial ornamentation in male Chrysolophuspheasants, Biology Letters (2025). DOI: 10.1098/rsbl.2025.0405

    Part2

  • Dr. Krishna Kumari Challa

    Why watching someone get hurt on screen makes you wince: How the brain triggers echoes of touch sensation

    Many people say that seeing bodily injury on film makes them flinch, as if they "feel" it themselves. It is as if the sting leaps straight off the screen and into your skin. 

    But explaining why and how this happens has puzzled scientists for a long time. Now, scientists have uncovered a major clue as to why. Parts of the brain originally thought to only process vision are also organized according to a "map" of the body, allowing what we see to trigger echoes of touch sensations. 

    The study, published recently (Wednesday, 26 November), in the journal Nature, shows that watching movies can activate touch-processing regions of your own brain in a highly organized way. In short, your brain doesn't just watch, it simulates what it sees. 

    When you watch someone being tickled or getting hurt, areas of the brain that process touch light up in patterns that match the body part involved. Your brain maps what you see onto your own body, 'simulating' a touch sensation even though nothing physical happened to you.

    This cross-talk works in the other direction too. For example, when you navigate to the bathroom in the dark, touch sensations help your visual system create an internal map of where things are, even with minimal visual input. This 'filling in' reflects our different senses cooperating to generate a coherent picture of the world.

    Nicholas Hedger, Vicarious body maps bridge vision and touch in the human brain, Nature (2025). DOI: 10.1038/s41586-025-09796-0. www.nature.com/articles/s41586-025-09796-0

    Part1

  • Dr. Krishna Kumari Challa

    To show how it is possible that our sense of touch is activated purely by visual information, the researchers developed novel methods to analyze brain activity in 174 people while they watched films such as "The Social Network" and "Inception."Surprisingly, brain regions traditionally considered to process purely visual information showed patterns that reflected sensations on the viewer's own body, not just what appeared on screen. These visual regions contained "maps" of the body similar to those usually found in touch-processing areas of the brain. In other words, the "machinery" the brain uses to process touch is "baked in" to our visual system.The study found two ways these body maps line up with visual information. In dorsal (higher up) regions of the visual system, body maps match where things appear in our field of view: Parts of the brain tuned to feet sensations were also tuned to lower parts of the visual scene, while parts tuned to face sensations were also tuned to upper parts of the visual scene. In ventral (lower down) regions, the body maps match what body part someone is looking at, regardless of where it appears in the visual scene. Put simply, our visual system is intimately connected to our sense of touch, mapping what we observe onto the coordinates of our body.The researchers are particularly excited by the clinical applications of this research. Dr. Hedger said, "This discovery could transform how we understand conditions like autism."Many theories suggest that internally simulating what we see helps us understand other people's experiences, and these processes may work differently in autistic people. Traditional sensory tests are exhausting, especially for children or people with clinical conditions. We can now measure these brain mechanisms while someone simply watches a film, opening up new possibilities for research and diagnosis."

    Part2

  • Dr. Krishna Kumari Challa

    How to turn water into wine using Raisins

    Sun-dried raisins submerged in water can reliably ferment into wine due to a high abundance of Saccharomyces cerevisiae on their surfaces, unlike fresh grapes. Successful fermentation was observed only with sun-dried raisins, yielding higher ethanol concentrations and a dominance of alcohol-producing yeasts. Oil-coated commercial raisins do not support this process.

    https://phys.org/news/2025-11-wine-raisins.html?utm_source=nwletter...
  • Dr. Krishna Kumari Challa

    Virus battles drug-resistant infections

    Jumbo bacteriophages, viruses that infect bacteria, possess unique shielded compartments protecting their genetic material and can evade bacterial immune defenses. Advances in imaging have revealed these features, suggesting that engineered jumbo phages could offer effective therapies against drug-resistant bacterial infections, addressing a growing global health threat.

    Thomas G. Laughlin et al, Architecture and self-assembly of the jumbo bacteriophage nuclear shell, Nature (2022). DOI: 10.1038/s41586-022-05013-4

  • Dr. Krishna Kumari Challa

    Scientists recruit bed bugs as crime scene sleuths

    Tropical bed bugs can retain human DNA for up to 45 days after feeding, enabling recovery of phenotypic traits such as gender, eye, hair, and skin color using STR and SNP markers. Their limited mobility and tendency to remain hidden make them valuable forensic tools at crime scenes, though their usefulness is restricted to recent events within a 45-day window.

  • Dr. Krishna Kumari Challa

    Reprogrammed Human Stomach Organoids Secrete Insulin

    Transplanting human gastric organoids engineered to release insulin in diabetic mice reduced hyperglycemia, offering a therapeutic avenue for type 1 diabetes.

    An estimated 9.5 million people all over the world live with type 1 diabetes, wherein the beta cells in their pancreas cannot produce enough insulin to keep blood glucose in check. In the long run, elevated glucose can damage organs such as the kidneys, heart, and eyes. Over the past few decades, scientists have been studying how to generate functional insulin-secreting cells which could be transplanted into patients.

    Now, researchers engineered human stomach organoids to secrete insulin. Transplanting these into diabetic mice reduced hyperglycemia. Their findings, published today in Stem Cell Reports, could help develop technologies to engineer a person’s own insulin-secreting cells for diabetes treatment.

    Lu J, et al. Modeling in vivo induction of gastric insulin-secreting cells using.... Stem Cell Rep. 2025. 

  • Dr. Krishna Kumari Challa

    Switching immune cells to 'night mode' could limit damage after a heart attack

    Researchers have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils.
    The study, published in the Journal of Experimental Medicine (JEM), suggests that inhibiting these fluctuations could prevent neutrophils from causing excessive tissue damage during daylight hours, a phenomenon that may underlie the fact that heart attacks in the early morning are more damaging than heart attacks suffered at night.
    Neutrophils provide the first line of defense against microbial infections and tissue injury. However, their efforts to promote inflammation and kill injured or infected cells can result in the death of nearby healthy cells. In fact, neutrophils have an internal clock that makes them more active and prone to cause tissue damage during the daytime.
    This could help explain the long-standing observation that heart attacks in the early morning have more severe consequences than heart attacks at night, because excessive neutrophil activity contributes significantly to the size of myocardial infarcts and long-term reductions in cardiac function.
    So scientists realized that targeting the neutrophil clock could provide a simple and effective means to blunt the toxic activity of these cells during myocardial infarctions, without compromising antimicrobial defense.
    They performed a series of experiments to confirm that, like in humans, mice suffer greater cardiac tissue damage after a heart attack in the early morning, and that this is due to enhanced neutrophil activity at this time of the day.

    Treating mice with a drug that inhabits the neutrophil clock reduced the amount of myocardial tissue damage after a heart attack and helped to preserve heart function over the following days and weeks.

    The drug, known as ATI2341, targets a receptor protein on the surface of neutrophils and switches the cells into a less active mode usually only seen at night.

    In their active, daytime mode, neutrophils accumulate around the edge of the initial wound caused by a heart attack, where they are poised to damage neighboring healthy cardiac tissue and extend the size of the injury. In night mode, however, neutrophils accumulate in the center of the initial wound, well away from the surrounding, healthy tissue.

    Part 1

  • Dr. Krishna Kumari Challa

    ATI2341 also protected mice from several other types of neutrophil-induced tissue damage but, crucially, did not impair the animals' ability to fend off bacterial and fungal infections.

    Aroca-Crevillén et al. A circadian checkpoint relocates neutrophils to minimize injury, Journal of Experimental Medicine (2025). DOI: 10.1084/jem.20250240

    Part2

  • Dr. Krishna Kumari Challa

    'Self-activation' is part of the success strategy of parasitic weeds 

    Certain parasitic weeds can autonomously activate their feeding organs (haustoria) before encountering a host by producing and releasing specific substances from their seeds. This early self-activation enables rapid and effective host attachment, contributing to their persistence and difficulty of control in agriculture. The process is influenced by compounds from both host and non-host seeds, and targeting these early signaling pathways may offer new weed management strategies.

    Guillaume Brun et al, Seed metabolites headstart haustoriogenesis and potentiate aggressiveness of parasitic weeds, Science Advances (2025). DOI: 10.1126/sciadv.aea1449

  • Dr. Krishna Kumari Challa

    Fat tissue around the heart may contribute to greater heart injury after a heart attack 

    Greater epicardial adipose tissue (EAT) volume, measured by cardiovascular imaging, is independently associated with larger myocardial infarct size and greater area at risk after myocardial infarction, though not with reduced left ventricular ejection fraction. Non-invasive EAT quantification may enhance cardiovascular risk assessment beyond traditional factors.

    Epicardial adipose tissue (EAT) is the layer of fat between the myocardium and the lining of the heart, directly surrounding the coronary arteries. Under certain pathological conditions, EAT releases inflammatory mediators leading to myocardial infiltration and constrictive effects. Over time, adverse remodeling of the myocardium can occur.

    Researchers have now shown that patients with increased EAT volume exhibited greater acute myocardial injury following MI.

    https://www.escardio.org/The-ESC/Press-Office/Press-releases/fat-ti...

  • Dr. Krishna Kumari Challa

    Abdominal obesity and muscle loss increase the risk of death by 83% after age 50, study finds

    A study by researchers concluded that the combination of abdominal fat and muscle loss increases the risk of death by 83%, compared to people without these conditions.
    This combination is so dangerous that it identifies an even greater problem: sarcopenic obesity. This condition is characterized by loss of muscle mass while gaining fat throughout the body. It is a difficult condition to diagnose, and it is related to loss of autonomy and a worsening quality of life in older adults. It is also known as frailty syndrome and is associated with an increased risk of falls and other comorbidities.
    Valdete Regina Guandalini et al, Can simple measures from clinical practice serve as a proxy for sarcopenic obesity and identify mortality risk?, Aging Clinical and Experimental Research (2024). DOI: 10.1007/s40520-024-02866-9
  • Dr. Krishna Kumari Challa

    Gut bacteria's hidden toxin acts as DNA glue, fueling colorectal cancer risk

    Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable bacterial product causes mutations in DNA that have been linked to colorectal cancer. Because it breaks down quickly, isolating and studying it has been difficult, but now scientists  have discovered exactly how colibactin attacks DNA.
    Using advanced tools such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, the team studied the toxin at the atomic level, as reported in a paper published in the journal Science. The scientists overcame colibactin's instability by growing toxin-producing bacteria directly next to strands of DNA in the lab. Consequently, colibactin attacked the genetic material almost as soon as it was made. 

    The study authors discovered that the toxin doesn't target genetic material at random. It homes in on DNA sequences with high quantities of adenine and thymine bases. The way it damages DNA is by creating a bridge-like connection, called an interstrand cross-link (ICL), between the two strands of the DNA helix. In effect, the toxin acts like glue, binding the two strands together. This damage is permanent and prevents the cell from correctly reading or copying its DNA, which ultimately results in genetic errors that can lead to cancer.

    The researchers also revealed that the damage occurs at the same place, in the minor groove. This is the narrow, shallow groove that is formed where the DNA's backbones are closest together. And the reason is the toxin has an unstable, positively charged core that is attracted to the negatively charged, AT-rich minor groove. So they fit together like a lock and key.

    The research is a significant advance in our understanding of the direct link between gut microflora and cancer risk. The discovery that colibactin binds to DNA at a specific site explains the characteristic DNA mutations doctors observe in colorectal cancer patients. 
    Now that scientists know the structure of the ICL bridge and the mechanism of attack, it can help them develop diagnostic tools to screen people at higher risk and design therapeutics to neutralize the unstable core. It could even inform new ways to reduce cancer risk through dietary changes or treatments that reduce the number of colibactin-producing bacteria in the gut. 

    Erik S. Carlson et al, The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin, Science (2025). DOI: 10.1126/science.ady3571

    Orlando D. Schärer, Molecular basis of DNA cross-linking by bacteria, Science (2025). DOI: 10.1126/science.aec9205

  • Dr. Krishna Kumari Challa

    Tattoos might put the immune system at risk

     Studies in mice suggest that the pigment used in tattoos accumulates in the lymph nodes and might affect immune responses. Researchers found that ink remained in the lymph nodes for months and had varying effects: it weakened the animals’ response to a COVID vaccine but increased the reaction to an influenza vaccine.

    https://www.pnas.org/doi/10.1073/pnas.2510392122

  • Dr. Krishna Kumari Challa

    Space debris poses growing threat, but new study suggests cleanup is feasible

    High up in Earth's orbit, millions of human-made objects large and small are flying at speeds of over 15,000 miles per hour. The objects, which range from inactive satellites to fragments of equipment resulting from explosions or collisions of previously launched rockets, are space debris, colloquially referred to as space junk. Sometimes the objects collide with each other, breaking into even smaller pieces.
    No matter the size, all of this debris poses a problem. Flying at high speeds caused by prior launches or explosions, they create danger for operational satellites and spacecraft, which are vital for the efficacy of modern technologies like GPS, digital communication and weather forecasting. At orbital speeds, even tiny fragments can cause significant damage to operational equipment, endangering future space missions and the people who would participate in them. 
    Even if a tiny, five-millimeter object hits a solar panel or a solar array of a satellite, it could break it .  And we have over 100 million objects smaller than one centimeter in orbit. So if you want to avoid a collision, you have to maneuver your spacecraft, which takes up fuel and is costly. Additionally, we have humans on the International Space Station who sometimes must go outside the spacecraft where the space debris can hit them too. It's really dangerous.

    Cleaning up space junk is technologically challenging and expensive. Furthermore, there are currently no incentives for countries or private companies to do so. Without binding international regulations or an enforceable "polluter pays" principle with consequences for noncompliance, the circumstances have led to a "cosmic free-for-all."

    Part1

  • Dr. Krishna Kumari Challa

    So in his latest study, titled "Space Logistics Analysis and Incentive Design for Commercialization of Orbital Debris Remediation" and published in the Journal of Spacecraft and Rockets, researchers investigated ways to create commercial opportunities for space operators and debris remediators to clean up dangerous junk.

    The study analyzed three possible scenarios of debris cleanup—controlled reentry back to Earth, uncontrolled reentry back to Earth, and recycling in space. All three methods would require a space debris remediation satellite - a vehicle designed to capture and remove space junk from orbit. 

    In the uncontrolled re-entry scenario, the remediation service vehicle would grab the debris from the orbit path it flies in and bring it down to about 350 kilometers away from Earth. The piece of debris would continue orbiting around our planet until it entered the atmosphere and either burned or landed someplace.

    It will either burn or drop somewhere on Earth, but we don't know where because it depends on the atmospheric drag it receives. This uncontrolled reentry method is the cheapest as the remediation vehicle doesn't have to fly long distances.

    In the controlled reentry scenario, the remediation service vehicle would bring the debris much closer to Earth, down to about 50 kilometers.  Controlled reentry is more expensive because the servicer needs to bring the debris down closer to Earth and then fly up again to get the next piece of debris. That consumes more energy and more fuel than an uncontrolled reentry .

    In the recycling scenario, the debris would be transported from its original orbit to a recycling center up in space. The transportation would require fuel, adding to the cost, but a lot of energy would also be saved by reusing aluminum, the metal commonly used in spacecraft, up in orbit rather than having to bring it up from Earth.

    It takes about $1,500 per kilogram to launch anything from Earth to space.  . So if you don't have to launch from Earth, it's a benefit.

    Space operators stand a lot to gain from debris removal. Their satellites can operate more safely and efficiently, so they save money on fuel and operations, since they don't have to make extra maneuvers to avoid collisions.

    Asaad Abdul-Hamid et al, Space Logistics Analysis and Incentive Design for Commercialization of Orbital Debris Remediation, Journal of Spacecraft and Rockets (2025). DOI: 10.2514/1.a36465

    https://phys.org/news/2025-12-space-debris-poses-threat-cleanup.htm...

    part2

  • Dr. Krishna Kumari Challa

    Most normal matter in the universe isn't found in planets, stars or galaxies

    Only about 9% of the universe’s normal (baryonic) matter is found in stars and cold gas within galaxies, while 76% resides in the intergalactic medium and 15% in galaxy halos. This distribution matches Big Bang predictions, confirming that most normal matter exists as diffuse gas between galaxies, not in visible structures. Dark matter and dark energy remain the dominant, poorly understood components.

  • Dr. Krishna Kumari Challa

    Classical Indian dance inspires new ways to teach robots how to use their hands  

    Analysis of Bharatanatyam dance gestures revealed a more versatile set of hand movement synergies than those found in natural grasps. These mudra-derived synergies enabled robots to replicate a wider range of hand motions, such as American Sign Language letters, more effectively. The findings support developing task-specific movement libraries for robotics and physical therapy applications.

    Parthan Olikkal et al, Reconstructing hand gestures with synergies extracted from dance movements, Scientific Reports (2025). DOI: 10.1038/s41598-025-25563-7

  • Dr. Krishna Kumari Challa

    For the first time, researchers observe how influenza viruses infect living cells 

     A novel microscopy technique enabled real-time, high-resolution observation of influenza virus entry into living cells. Findings show that cells actively participate in viral uptake by recruiting clathrin proteins and forming membrane pockets, rather than being passive targets. This method offers valuable insights for antiviral drug development and can be applied to study other viruses.

    Aiko Yoshida et al, Enhanced visualization of influenza A virus entry into living cells using virus-view atomic force microscopy, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2500660122

  • Dr. Krishna Kumari Challa

    Single enzyme failure found to drive neuron loss in dementia 

     Loss of function in the enzyme glutathione peroxidase 4 (GPX4) disrupts neuronal protection against ferroptosis, leading to neuron death and early-onset dementia. A specific GPX4 mutation impairs its ability to neutralize lipid peroxides at the cell membrane, triggering neurodegeneration. Inhibiting ferroptosis can slow this process in experimental models.

    Svenja M. Lorenz et al, A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis, Cell (2025). DOI: 10.1016/j.cell.2025.11.014

    https://medicalxpress.com/news/2025-12-enzyme-failure-neuron-loss-d...

  • Dr. Krishna Kumari Challa

    Human hair grows through 'pulling' not pushing

    Scientists have found that human hair growth does not grow by being pushed out of the root; it's actually pulled upward by a force associated with a hidden network of moving cells. The findings challenge decades of textbook biology and could reshape how researchers think about hair loss and regeneration.
    Researchers  used advanced 3D live imaging to track individual cells within living human hair follicles kept alive in culture. The study, published in Nature Communications, shows that cells in the outer root sheath—a layer encasing the hair shaft—move in a spiral downward path within the same region from where the upward pulling force originates.
    To test this, the researchers blocked cell division inside the follicle, expecting hair growth to stop. Instead, growth continued nearly unchanged. But when they interfere with actin—a protein that enables cells to contract and move—the hair growth rate dropped by more than 80%. 
    Computer models confirmed that this pulling force, correlated with coordinated motion in the follicle's outer layers, was essential to match the observed speeds of hair movement. 
    The researchers  used a novel imaging method allowing 3D time lapse microscopy in real-time. While static images provide mere isolated snapshots, 3D time-lapse microscopy is indispensable for truly unraveling the intricate, dynamic biological processes within the hair follicle, revealing crucial cellular kinetics, migratory patterns, and rate of cell divisions that are otherwise impossible to deduce from discrete observations. This approach made it possible to model the forces generated locally.
    This reveals that hair growth is not driven only by cell division—instead, the outer root sheath actively pulls the hair upward. This new view of follicle mechanics opens fresh opportunities for studying hair disorders, testing drugs and advancing tissue engineering and regenerative medicine.
      The study also highlights the growing role of biophysics in biology, showing how mechanical forces at microscopic scale shape the organs we see every day. 
    Nicolas Tissot et al, Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth, Nature Communications (2025). DOI: 10.1038/s41467-025-65143-x
  • Dr. Krishna Kumari Challa

    How volcanic eruptions set off a chain of events that brought the Black Death to Europe

    Clues contained in tree rings have identified mid-14th-century volcanic activity as the first domino to fall in a sequence that led to the devastation of the Black Death in Europe. 
    Researchers  have used a combination of climate data and documentary evidence to paint the most complete picture to date of the "perfect storm" that led to the deaths of tens of millions of people, as well as profound demographic, economic, political, cultural and religious change.

    Their evidence suggests that a volcanic eruption—or cluster of eruptions—around 1345 caused annual temperatures to drop for consecutive years due to the haze from volcanic ash and gases, which in turn caused crops to fail across the Mediterranean region. To avoid riots or starvation, Italian city states used their connections to trade with grain producers around the Black Sea.

    This climate-driven change in long-distance trade routes helped avoid famine, but in addition to life-saving food, the ships were carrying the deadly bacterium that ultimately caused the Black Death, enabling the first and deadliest wave of the second plague pandemic to gain a foothold in Europe.

    This is the first time that it has been possible to obtain high-quality natural and historical proxy data to draw a direct line between climate, agriculture, trade and the origins of the Black Death. The results are reported in the journal Communications Earth & Environment

    The researchers say the "perfect storm" of climate, agricultural, societal and economic factors after 1345 that led to the Black Death can also be considered an early example of the consequences of globalization.

    Although the coincidence of factors that contributed to the Black Death seems rare, the probability of zoonotic diseases emerging under climate change and translating into pandemics is likely to increase in a globalized world.

    The researchers say that resilience to future pandemics requires a holistic approach to address a wide spectrum of health threats. Modern risk assessments should incorporate knowledge from historical examples of the interactions between climate, disease and society. 

    Climate-driven changes in Mediterranean grain trade mitigated famine but introduced the Black Death to medieval Europe, Communications Earth & Environment (2025). DOI: 10.1038/s43247-025-02964-0

  • Dr. Krishna Kumari Challa

    How volcanic eruptions set off a chain of events that brought the Black Death to Europe
    Volcanic eruptions around 1345 triggered consecutive years of cooling, leading to crop failures and famine in southern Europe. To prevent starvation, Italian city states imported grain from the Black Sea, inadvertently introducing Yersinia pestis via infected fleas on ships. This sequence of climate, agricultural, and trade events enabled the Black Death's rapid spread across Europe.

  • Dr. Krishna Kumari Challa

    'Brainquake' phenomenon links psychotic states to chaotic information flow

    Some psychiatric disorders, particularly schizophrenia and bipolar disorder (BP), can prompt the emergence of so-called psychotic states, mental states characterized by distorted thinking patterns, altered perceptions and unusual beliefs. Detecting and diagnosing these states is not always easy, as they often overlap with the symptoms of other mental health disorders, and reliable methods to identify psychosis are still lacking.
    Researchers  recently carried out a study aimed at further exploring the neural signatures of psychotic states. Their findings, published in Molecular Psychiatry, suggest that the activity in the brains of individuals who are experiencing psychosis is significantly more random, following patterns that hint at an unstable flow of information.
    As part of their study, the researchers scanned the brains of individuals diagnosed with BP or schizophrenia using fMRI.  They looked at the complexity of the activity patterns in the participants' brains. Moreover, they tried to understand how information flowed between different brain regions, used tools rooted in information theory. Specifically, they tried to measure the overlapping of information (i.e., redundancy) and combination of information (i.e., synergy) within specific brain networks. 
    To further investigate these disruptions, they estimated brain network connectivity using redundancy and synergy measures, aiming to assess the integration and segregation of topological information in the psychotic brain. Their findings reveal a disruption in the balance between redundant and synergistic information, a phenomenon they term brainquake in this study, which highlights the instability and disorganization of brain networks in psychosis.
    They found that this "brainquake" disruption resulted in a widespread instability across several neural networks involved in the processing of emotions and sensory information, as well as memory and other mental functions. 
    This  exploration of higher-order topological functional connectivity reveals profound disruptions in brain information integration, wrote the authors in their research paper.
    Aberrant information interactions were observed across both cortical and subcortical ICNs. They specifically identified the most easily affected irregularities in the sensorimotor, visual, temporal, default mode, and fronto-parietal networks, as well as in the hippocampal and amygdalar regions, all of which showed disruptions. 
    The findings underscore the severe impact of psychotic states on multiscale critical brain networks, suggesting a profound alteration in the brain's complexity and organizational states.
    Qiang Li et al, Spatiotemporal complexity in the psychotic brain, Molecular Psychiatry (2025). DOI: 10.1038/s41380-025-03367-5
  • Dr. Krishna Kumari Challa

    NASA discovers new bacteria 'playing dead'

    New research conducted on a NASA-discovered bacterium shows the microbe is capable of entering an extreme dormant state, essentially "playing dead" to survive in some of the cleanest environments on Earth. 

    The finding could potentially reshape how scientists think about microbial survival on spacecraft and the challenges of preventing contamination during missions to space. Preventing contamination matters because it helps keep space missions safe, while ensuring that any signs of life spotted elsewhere in the solar system can be trusted.

    It shows that some microbes can enter ultra-low metabolic states that let them survive extremely austere environments, including clean rooms that naturally select for the hardiest organisms.

    The fact that this bacterium can intentionally suspend its metabolism makes survival on spacecraft surfaces or during deep-space cruise more plausible than previously assumed .

    What stood out most to me is that these microbes don't form spores .  Seeing a non-spore-former achieve comparable robustness through metabolic shutdown alone suggests there are additional, underappreciated survival mechanisms in bacteria that we haven't fully characterized.

    Madhan Tirumalai et al, Tersicoccus phoenicis (Actinobacteria), a spacecraft clean room isolate, exhibits dormancy, Microbiology Spectrum (2025). DOI: 10.1128/spectrum.01692-25

  • Dr. Krishna Kumari Challa

    Deadly Asian floods are no fluke.

    They're a climate warning, scientists say Southeast Asia is experiencing increasingly severe and unpredictable floods and storms, consistent with climate change projections. The region is warming nearly twice as fast as the global average, intensifying extreme weather events. Governments are struggling to prepare for and respond to these disasters, which are exacerbated by deforestation and unregulated development. Economic losses are substantial, while climate finance remains insufficient.
    Climate patterns last year helped set the stage for 2025's extreme weather.Atmospheric levels of heat-trapping carbon dioxide jumped by the most on record in 2024. That "turbocharged" the climate, the United Nation's World Meteorological Organization says, resulting in more extreme weather.Asia is bearing the brunt of such changes, warming nearly twice as fast as the global average. Scientists agree that the intensity and frequency of extreme weather events are increasingWarmer ocean temperatures provide more energy for storms, making them stronger and wetter, while rising sea levels amplify storm surges While the total number of storms may not dramatically increase, their severity and unpredictability will What we're seeing in the region is dramatic and it's unfortunately a stark reminder of the consequences of the climate crisis, scientists conclude.
    Source: News Agenices

  • Dr. Krishna Kumari Challa

    Electric vehicle high-nickel batteries: Fundamental cause of performance degradation identified

    Succinonitrile (CN4), an electrolyte additive previously used to enhance stability in lithium-ion batteries, has been identified as a primary cause of rapid degradation in high-nickel batteries. CN4 binds strongly to nickel ions, disrupting the cathode’s protective layer, causing structural damage, and accelerating performance loss.

    Seung Hee Han et al, Unveiling Bidentate Nitrile-Driven Structural Degradation in High-Nickel Cathodes, ACS Energy Letters (2025). DOI: 10.1021/acsenergylett.5c02845

  • Dr. Krishna Kumari Challa

    Ant brood signal deadly infection in altruistic self-sacrifice

    Terminally ill ant pupae emit specific non-volatile odor signals that prompt worker ants to remove and disinfect them, preventing pathogen spread within the colony. This targeted signaling occurs only when infections are uncontrollable, ensuring colony health while minimizing unnecessary sacrifice, and parallels immune responses in multicellular organisms.

    Sylvia Cremer, Altruistic disease signalling in ant colonies, Nature Communications (2025). DOI: 10.1038/s41467-025-66175-zwww.nature.com/articles/s41467-025-66175-z

  • Dr. Krishna Kumari Challa

    Fossils reveal anacondas have been giants for over 12 million years

    Researchers  analyzed giant anaconda fossils from South America to deduce that these tropical snakes reached their maximum size 12.4 million years ago and have remained giants ever since.

    Many animal species that lived 12.4 to 5.3 million years ago, in the period known as the "Middle to Upper Miocene," were much bigger than their modern relatives due to warmer global temperatures, extensive wetlands and an abundance of food.

    While other Miocene giants—like the 12-meter caiman (Purussaurus) and the 3.2-meter giant freshwater turtle (Stupendemys)—have since gone extinct, anacondas (Eunectes) bucked the trend by surviving as a giant species.

    Anacondas are among the largest living snakes in the world. They are usually four to five meters long and in rare cases can reach seven meters.

    The team measured 183 fossilized anaconda backbones, representing at least 32 snakes, discovered in Falcón State in Venezuela, South America. Combining these measurements with fossil data from other sites in South America allowed them to calculate that ancient anacondas would have been four to five meters long. This matches the size of anacondas that exist today. 
    An early origin of gigantism in anacondas (Serpentes: Eunectes) revealed by the fossil record, Journal of Vertebrate Paleontology (2025). DOI: 10.1080/02724634.2025.2572967
  • Dr. Krishna Kumari Challa

    Cancer cells keep their chromosomes intact to continue dividing relentlessly

    Cancer cells maintain their ability to divide by using telomerase to repair chromosome ends (telomeres). An internal actin protein network in the nucleus helps telomerase access damaged telomeres, supporting cell survival even after chemotherapy-induced DNA damage. Targeting telomerase or this actin network could enhance chemotherapy effectiveness and reduce side effects.

    Ashley Harman et al, Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase, Nature Communications (2025). DOI: 10.1038/s41467-025-66506-0

  • Dr. Krishna Kumari Challa

    Scientists call for greater focus on conserving whole ecosystems instead of charismatic species

    Conservation programs are often too focused on a single charismatic species.

     

    With many species worldwide experiencing population declines, there is an urgent need for conservation initiatives to support their recovery. However, this urgency, combined with insufficient scientific knowledge about endangered species, means that conservationists have often relied on oversimplified measures of success. For example, historical conservation efforts often focused on the abundance of a single charismatic species as a proxy for overall ecosystem health.

     

    Researchers highlight three examples from China where oversimplified conservation priorities led to negative outcomes. The Chinese giant salamander (Andrias davidianus) is known as a "cryptic species," because it has multiple, genetically distinct populations that look identical to the naked eye.

    Unaware of this, conservationists began a large-scale captive breeding and reintroduction program, which led to genetic mixing that threatened native populations. In the case of the crested Ibis (Nipponia nippon) and Père David's deer (Elaphurus davidianus), intensive captive breeding and release programs with limited suitable habitat have resulted in overcrowding, inbreeding and increased mortality.

    Although well-intentioned, these initiatives have caused unforeseen issues for the ecosystem, and have often failed to improve the conservation status of the target species.

    To avoid repeating these mistakes, the researchers advocate for a more nuanced approach to conservation, focused on creating balanced ecosystems, restoring habitats and minimizing human intervention. Although there has recently been more emphasis placed on protecting whole ecosystems, charismatic species conservation is still prevalent in the world.

    Conservation programs that aim to preserve and restore ecosystem functions are a more effective use of limited resources, and are less likely to have unintended consequences, the researchers say. 

    Shi H-T, et al. Are we over-conserving charismatic species? PLOS Biology (2025). DOI: 10.1371/journal.pbio.3003494

  • Dr. Krishna Kumari Challa

    Playing specific bat-like ultrasounds can suppress moth reproduction, offering a smart way to protect crops

    Exposure to bat-like ultrasonic pulses alters the behavior of Autographa nigrisigna moths, with higher pulse repetition rates causing erratic flight or flight cessation, especially in egg-bearing females. This response reduces egg-laying and suggests that ultrasonic cues can be used to suppress moth reproduction, offering a potential environmentally friendly method for crop protection.

    Ming Siang Lem et al, Ultrasonic pulse repetition rates triggering escape responses of a moth pest, Pest Management Science (2025). DOI: 10.1002/ps.70204

  • Dr. Krishna Kumari Challa

    Cancer-promoting DNA circles hitchhike on chromosomes to spread to daughter cells

    Extrachromosomal DNA circles (ecDNA) in cancer cells persist by attaching to chromosomes during cell division using specific retention elements, mimicking natural gene regulation mechanisms. Disrupting this attachment, such as by adding methyl groups to retention elements, leads to ecDNA loss and reduced cancer cell survival, highlighting a potential therapeutic target for cancer treatment.

    Venkat Sankar et al, Genetic elements promote retention of extrachromosomal DNA in cancer cells, Nature (2025). DOI: 10.1038/s41586-025-09764-8

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  • Dr. Krishna Kumari Challa

    Images that require less neural energy to process are generally rated as more aesthetically pleasing, indicating that visual preference may be influenced by the brain's tendency to conserve energy. This suggests that aesthetic appreciation is linked to a balance between adequate visual stimulation and minimizing metabolic expenditure.

     

    Beauty may be 'easy on the eyes' because it saves brain power

    Humans may find images that take less energy to process aesthetically pleasing, suggesting that our attraction to beauty is at least partially an energy conservation strategy. 

    Looking at something can feel effortless, but in energetic terms, it isn't cheap. The brain uses 20% of the body's energy, and the visual system accounts for about 44% of that expenditure. Looking at very simple stimuli, like a blank white room, is energy-efficient but boring. Looking at very busy or unusual images can feel tiring and unpleasant. 

    Publishing in PNAS Nexus, researchers presented 4,914 images of objects and scenes to an in-silico model of the visual system to estimate the number of neurons needed to look at them. The authors compared these estimates to enjoyment ratings from 1,118 participants recruited using Amazon Mechanical Turk.

    Next, they used blood oxygen level-dependent signal brain imaging to measure the energy costs of looking at images for 4 participants. In both experiments, study participants found images that took less energy to process more attractive. The authors asked for a quick response, meant to capture initial impressions, not the more complex pleasures that may arise from contemplating an image in a broader context by engaging with its meaning.

    According to the authors, visual aesthetic appreciation may be a manifestation of an energy-conserving heuristic that creates a sweet spot between sufficient stimulation of the visual system and excessive metabolic cost.

    Yikai Tang et al, Less is more: Aesthetic liking is inversely related to metabolic expense by the visual system, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf347

  • Dr. Krishna Kumari Challa

    Why dogs hide food and toys

    No, they  aren't stockpiling their food due to anxiety about impending disaster. 
    Instead, they're revealing how their evolutionary past still shapes modern behaviors. This forward-thinking strategy offers us a unique window into how we can help them live well. 

    "Caching," is the scientific term for storing food in hidden places for later use. This behaviour is widespread across the animal kingdom, from squirrels, to crows, and wolves.

    Caching behavior generally falls into one of two categories.

    One is known as larder hoarding—think of a squirrel stashing nuts in just one or two places to draw from as they get through a long winter. 

     The other is known as scatter hoarding. It is where animals make smaller caches of surplus food in many different locations, reducing the chance of losing everything to a competitor or going hungry in lean seasons. It's mostly seen in wild canids such as foxes and wolves.  

    This behavior in modern dogs is an instinctual remnant. It reflects the competitive feeding patterns of their ancestors who lived by hunting, for whom securing food was unpredictable, but crucial for survival. 

     Dogs appear to rely on a combination of scent and observational spatial memory to remember where they have cached special items, such as food, treats and toys.

    https://theconversation.com/your-dog-is-not-a-doomsday-prepper-here...

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  • Dr. Krishna Kumari Challa

    Fatty food smells during pregnancy may raise obesity risk in offspring

    Exposure to fatty food odors during pregnancy and breastfeeding, even without maternal weight gain or high-fat intake, can alter offspring brain circuits related to reward and metabolism, increasing their risk of obesity and insulin resistance. Ingested flavoring agents with fatty odors were sufficient to trigger these effects in mice, highlighting potential implications for human metabolic health.

    https://medicalxpress.com/news/2025-12-fatty-food-pregnancy-obesity...

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  • Dr. Krishna Kumari Challa

    Why your faucet drips: Water jet breakup traced to angstrom-scale thermal capillary waves

    The breakup of a water jet into droplets is primarily triggered by intrinsic thermal capillary waves—angstrom-scale surface fluctuations—rather than external disturbances or nozzle imperfections. These minute thermal oscillations are amplified by Rayleigh-Plateau instability, determining the breakup length across a wide range of jet sizes.

    Stefan Kooij et al, What Determines the Breakup Length of a Jet?, Physical Review Letters (2025). DOI: 10.1103/jf6w-l5sy

  • Dr. Krishna Kumari Challa

    A new possibility for life: Study suggests ancient skies rained down ingredients

    Earth's atmosphere might have contributed to the origin of life more than previously thought. In a study published in the Proceedings of the National Academy of Sciences,  researchers  reveal that billions of years ago, Earth's early sky might have been producing sulfur-containing molecules that were essential ingredients for life. 
    The finding challenges a long-held theory that these sulfur molecules emerged only after life had already formed. 
    Just like carbon, sulfur is an essential element found in all life forms, from single-cell bacteria to humans. It is part of some amino acids, which are the building blocks of protein. 

    While the young Earth's atmosphere contained sulfur elements, scientists had long thought that organic sulfur compounds, or biomolecules like amino acids, emerged later as a product of the living system.

    In previous simulations of early Earth, scientists either failed to detect meaningful amounts of sulfur biomolecules before life existed, or created the molecules only under specialized conditions that were unlikely to be widespread on this planet.

    As a result, when the James Webb Space Telescope  detected dimethyl sulfide, an organic sulfur compound produced by marine algae on Earth, on another planet called K2-18b, many thought it was a possible sign of life on other planets.

    Previously, these researchers  successfully created dimethyl sulfide in their lab using only light and common atmospheric gases. This suggested that this molecule could arise in places void of life.

    This time,they set off to see what early Earth's sky could have contributed. They shone light on a gas mixture containing methane, carbon dioxide, hydrogen sulfide and nitrogen to simulate Earth's atmosphere before life emerged.

      Using a highly sensitive mass spectrometry instrument that can identify and measure different chemical compounds, the team found that the early Earth simulation produced a whole suite of sulfur biomolecules, including the amino acids cysteine and taurine, as well as coenzyme M, a compound critical for metabolism. 

    When the team scaled their lab results to calculate how much cysteine an entire atmosphere could produce, they found that early Earth's sky might have brought cysteine to supply about one octillion—one followed by 27 zeros—cells. Currently, Earth boasts about one nonillion—one followed by 30 zeros—cells. 

    The team said in their paper these biomolecules formed in Earth's atmosphere might have fallen onto the ground or oceans with rain, helping to get life started.

      An Archean atmosphere rich in sulfur biomolecules, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2516779122

  • Dr. Krishna Kumari Challa

    How airplanes discharge static electricity

    An international team of scientists has observed radio wave emissions originating from a commercial airliner, most likely caused by the discharge of static electricity. The serendipitous observation of radio wave emissions from specific locations on the aircraft may be of interest to the aviation industry. 
    In addition, this has already enabled the team to identify a source of error in their imaging techniques. The results were published on 26 November in the journal Nature Communications
    Static electricity builds up through friction, for example, between your clothes and the fabric of your chair, but also in airplanes when they pass through frozen clouds. Airplanes are therefore fitted with electrostatic discharge wicks, which are designed to shed electrostatic charges in a way that does not cause dangerous sparks or interfere with the aircraft's communications. 
    Interestingly, the discharges observed by the researchers, while the airplane was cruising at an altitude of 8 kilometers, were located around the two engines and at one spot on the tail, rather than at the electrostatic discharge wicks. The events near the tail were measured with an accuracy of about 50 cm. 
    The observation was made using the Low-Frequency Array (LOFAR) radio telescope, an antenna network located mainly in the Netherlands and spanning seven other European countries. This telescope is primarily used for astronomy, but also for studying the formation of lightning. 
    This would be of interest to the aviation industry, as static charges can create sparks that may damage the plane, say the researchers.
    Olaf Scholten et al, Measuring location and properties of very high frequency sources emitted from an aircraft flying through high clouds, Nature Communications (2025). DOI: 10.1038/s41467-025-65667-2
  • Dr. Krishna Kumari Challa

    Monkeys have rhythm and can tap along to the beat

    Macaque monkeys can keep time to music and move to the beat. Well, at least two adult macaques can, who were trained by researchers to tap along to different kinds of music. Their work challenges the so-called vocal-learning hypothesis, which holds that only species with complex vocal learning, like humans and songbirds, can spontaneously move to the groove. Macaques are not vocal learners. 

    To explain this ability, the study authors proposed their "four components (4Cs) hypothesis." According to this idea, musical beat perception is not unique to vocal learners but rather arises from the combination of four general abilities.

    That is being able to hear the beat in music (auditory detection), anticipating the next beat (prediction), acting on the feedback (auditory-motor feedback) and the ability to coordinate these processes through reward (reward-based reinforcement).

    Vani G. Rajendran et al, Monkeys have rhythm, Science (2025). DOI: 10.1126/science.adp5220
  • Dr. Krishna Kumari Challa

    Scientists decode blood's hidden messengers

    Every second, trillions of tiny parcels travel through your bloodstream—carrying vital information between your body's cells. Now, scientists have opened this molecular mail for the first time, revealing its contents in astonishing detail. 
    In research published in Nature Cell Biology, Professor  they have mapped the complete molecular blueprint of extracellular vesicles (EVs)—nanosized particles in blood that act as the body's secret messengers. 

    For decades, researchers have known that EVs exist, ferrying proteins, fats, and genetic material that mirror the health of their cells of origin. But because blood is a complex mixture—packed with cholesterol, antibodies, and millions of other particles—isolating EVs has long been one of science's toughest challenges.

    These vesicles are like tiny envelopes sent between cells, delivering molecular updates about what's happening inside the body, Until now, researchers just couldn't open them properly to read the messages inside.

    But now using ultra-pure isolation techniques and cutting-edge multi-omics profiling, the team identified 182 proteins and 52 lipids that make up the core structure of human plasma EVs. They also pinpointed another set of molecules that distinguish EVs from other particles in the bloodstream—effectively decoding the body's molecular communication system. 

    To make this discovery accessible, the researchers developed EVMap, a free, interactive online resource that lets scientists worldwide explore the molecular makeup of blood EVs. 

    By decoding this molecular language, we can begin to read the body's own health reports, say the researchers. They have already identified EV signatures linked to early heart disease, which could pave the way for simple blood tests that predict risk long before symptoms appear.

      Alin Rai et al, Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma, Nature Cell Biology (2025). DOI: 10.1038/s41556-025-01795-7

  • Dr. Krishna Kumari Challa

    City raccoons showing signs of domestication

    Urban raccoons exhibit shorter snouts compared to rural populations, a trait associated with early domestication syndrome. This morphological change is likely driven by the advantages of tameness and reduced aggression in accessing human food waste. The findings suggest that proximity to humans can induce domestication-related traits in wild species.

    Artem Apostolov et al, Tracking domestication signals across populations of North American raccoons (Procyon lotor) via citizen science-driven image repositories, Frontiers in Zoology (2025). DOI: 10.1186/s12983-025-00583-1

  • Dr. Krishna Kumari Challa

    Which gut microbes matter most? Large study ranks bacteria by health and diet links

    The gut microbiome has been a rising star in the world of health science over the last several years, garnering interest from both researchers and the general public. This is mostly due to its connection to general health and diseases, like type 2 diabetes and heart disease, as well as the fact that it is a modifiable element of human health. However, the science surrounding the fascinating world of gut microbes is still developing and there is much to learn.

    A new study, published in Nature, has added significantly to our understanding of the human microbiome. The study team analyzed the gut microbiome, diet and health markers from over 34,500 people in the US and UK, and linked hundreds of specific gut microbe species to key indicators of health and diet. The data come from the Zoe PREDICT program in the UK and US, which is run by the microbiome testing company Zoe.

    The researchers used machine learning to link certain gut microbe species in 34,694 study participants to diet and common health risk factors such as BMI, triglycerides, blood glucose and HbA1c, as well as clinical markers that are intermediary measures of cardiometabolic health. Out of 661 non-rare microbial species, the researchers focused in on the 50 that were most favorably associated with good health and the 50 that were the most unfavorably associated with good health.

    This process resulted in the development of the "ZOE Microbiome Health Ranking 2025" and "Diet Ranking 2025," used to score microbes as either favorable or unfavorable for health on a scale of 0 to 1. Those closer to zero are considered positively correlated to the health markers and those closer to one are negatively correlated. This was done for all 661 microbes studied.

    The ranking system identified hundreds of gut microbe species—described as species-level genome bins (SGBs) in the paper—significantly associated with health markers and diet quality. They found that favorable microbes were more common in people with lower BMI and fewer diseases, while unfavorable microbes were more common in those with obesity and disease. A part of the study focusing on BMI, used data from 5,348 healthy individuals, and divided them into three BMI categories; healthy weight, overweight and obese.

    "Meta-analysis based on linear regression on single cohorts showed that individuals with healthy weight carried, on average, 5.2 more of the 50 favorably ZOE MB health-ranked SGBs than people with obesity," the study team writes.

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  • Dr. Krishna Kumari Challa

    The team also assessed whether the ZOE MB health-ranked SGBs were more abundant in participants with a defined disease. Indeed, they found that people in the control group had higher favorably ranked gut microbes than people with disease, and that those with diseases had more unfavorably ranked gut microbes than those without disease.

    Dietary interventions were also found to increase favorable microbes and reduce unfavorable ones. The team analyzed data from two studies, referred to as ZOE METHOD and BIOME, in which participants either followed a personalized dietary intervention program (PDP) designed to improve the microbiome or took a prebiotic supplement. The microbiomes of these participants changed significantly by the end of the studies.

    "The dietary intervention groups of both clinical trials that aimed at improving diet using different approaches (prebiotic blend for BIOME and PDP for METHOD) showed the highest number of significantly changing SGBs. Focusing on the most significant gut microbial SGBs with the largest change in relative abundance after dietary interventions, they found increasing Bifidobacterium animalis—a bacterium present in dairy-based foods and in the microbiome of people consuming larger amounts of them, an unknown Lachnospiraceae bacterium and R. hominis both previously associated with a vegan diet, and another unknown Lachnospiraceae bacterium linked to a vegetarian diet," the authors explain.

    In addition to linking known bacterial species to measures of health and diet, the team also discovered many key health-associated microbes that were previously uncharacterized species.

    Francesco Asnicar et al, Gut micro-organisms associated with health, nutrition and dietary interventions, Nature (2025). DOI: 10.1038/s41586-025-09854-7

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