SCI-ART LAB

Science, Art, Litt, Science based Art & Science Communication

                                                                            Interactive science series

Q: What training should a student get before joining Ph.D.?

Krishna: If a student gets comprehensive training  in research literature search, designing experiments, interpreting results and writing manuscripts for publications, scientific presentations, communication/presentation skills it would become very easy to conduct research, publish/present papers and get a Ph.D. in the shortest possible time.

However, I never received any training, most of my colleagues too never received any formal training, we found our own ways and completed our work with our own experiences learnt along the way. 

Q: Why are smaller sample sizes not good for research?

Krishna: Consider this example: You take 9 samples. 5 samples give one result  and 4 give the opposite one. Based on this observation if you say the majority (5) is correct, that would become erroneous because if you take 10 samples and  if the 10th one shows the the second set results, that becomes half- half. So smaller samples show more errors. You cannot come to correct conclusions based on them.

As you increase the sample size ( like  9000), the errors become less significant and show more appropriate results.  The use of small sample sizes could contain a skewed sample that shows stronger effects. Good results depend on seeing large-scale patterns across thousands of studies and meta-analyses.

Q: How can research results made reliable and scientists accountable?

Krishna: Experts say these things make research more valid - better trained scientists, more funding, more supervision and regulatory oversight, better control or transparency on conflicts of interest. 

Q:Why do people publish their papers in international conferences? What is the significance and importance of doing this?  

Krishna: You will get more coverage and recognition when you present  papers in international conferences. It also denotes that your paper is of high standard because only very good papers are selected for international conferences.

You will receive instant critical feed back from experts in the field which makes you improve yourself.

You will upgrade your presentation skills and discussion dialogues.

More significantly, you are standing up for your science before the international media.

Q: What are predatory journals? 

Krishna: The predatory journals are not genuine. They charge the researchers, accept manuscripts without reviewing them, print them without editing them, and otherwise make a mockery of the scientific literature by pumping out low-quality work.

You will find the list here: http://beallslist.weebly.com/

Q: Can one finish Ph.D. in 2 years?

Krishna: Extremely difficult especially in science subjects. You or your supervisor or the circumstances must be extraordinary to complete your research work in just two years in today’s world.

Q: Can a fresher with no research papers get admission to an MS in CS?

Krishna: Yes. Most of the students - at least from India - who join MS in Computer Science  don’t have any research papers.

Q: Is peer-review perfect?

Krishna: No! Peer-review is only as valuable as the expertise of the “peers” doing the “review”. That is why people still publish peer-reviewed papers  in alternative medicine and boast their papers are of good quality and insist that they be trusted. 

Q: How can a student of B.Sc. Physics write a research paper?

Krishna: You can write a research paper if you conducted original research and got results that are significant. If you think you have enough knowledge and confidence to do that go ahead by taking the help of your professors.

You can get some training in scientific research by joining a research group and doing some voluntary work. Also read all the available literature in the field to know how to proceed.

Q: Should the motivational letter for pursuing a PhD be written by the students or the professors?

Krishna: Unless you yourself are not motivated fully, other people can’t help you much. It should come from within first. The letters written by others can only augment your own motivation.

Q: Why does one want to do PhD?

Krishna: In my case… it is to gain more knowledge. To pursue the subject I love more vigorously. To get trained as a scientist.

It became easy for me to go ahead when I got top ranks in the University and a CSIR fellowship. 

Q: How do you know the people who do the peer-review of your paper are competent for the position? I once knew a first-year PhD student was asked to do peer-review for papers of a conference hosted by her adviser. I think first-year PhD is totally new, still have lots to learn…

Krishna: There is no way to learn about it unless the publishers tell you about it and they usually won’t!

You can’t escape some things not only in peer-reviewing but also in allocating projects, funds and in judging awards, prizes etc. Biases and incompetence are real and you need not feel sorry if you miss something despite having merit.

Lesson that should be learnt: Don’t lose your confidence because of somebody else’s bias and incompetence. 

Q: Are prophylactic antibiotics necessary?

Krishna: Antibiotic prophylaxis is the use of antibiotics before surgery or a dental procedure to prevent a bacterial infection. This practice isn’t as widespread now as it was 10 years ago. This is due to the increase in the resistance of bacteria to antibiotics, the change in bacteria that cause infections, improvements in technology that can detect infections early.

However, antibiotic prophylaxis is still used in people who have certain risk factors for bacterial infection. 

People who may need antibiotic prophylaxis usually have factors that put them at higher risk of infection during surgery than the general population. These factors include vulnerability with compromised immune systems like  very young or very old age of the patient, poor nutrition, obesity, diabetes, smoking, including a history of smoking, existing infection, even at a different site from where the surgery will be done, recent surgery, extended hospital stay before the procedure, certain congenital heart conditions, meaning ones that have existed since birth.

Antibiotic prophylaxis for dental procedures may be appropriate for people who have compromised immune systems, artificial heart valves, histories of infection in the heart valves or the lining of the heart, known as infective endocarditis, heart transplants that have led to problems with one of the heart valves.

In ordinary circumstances use of prophylactic antibiotics are not necessary . Moreover using them would increase the drug resistance in microbes.

Q: After reading your article this-is-what-a-liver-transplant-surgeon-told-me-recently

 I really got scared. Because we use ayurvedic medicines in our home. Are they really that bad? Is any research going on them to find out the truth?

Krishna: I will not say all of the ayurvedic medicines are bad. Some might have good qualities too. Until you test them scientifically you will never know about their qualities - good or bad. 

Yes, some people in the West have tested these medicines and found some bad qualities like my article states. But some Indian scientists and doctors too are studying the qualities of these medicines. 

I have been given this list:

1). Padma Vibushan and Chitra Cardiac valve inventor and World renowned cardiologist Dr. M.S.Valiathan [MBBSMSFRCS (England)FRCS (Edin.),FRCPS(C)FRCP( Lon)D.Sc (h.c)] who is into serious research in Ayurveda for the past 12 years.

2). Padma Bhushan Dr. B M Hegde [M.B.B.S from Stanley Medical College(Madras), a M.D. from King George Medical College (Lucknow), FRCP from Royal College of Physicians, London, Glasgow, Edinburgh, and Dublin. He also has a FACC and FAMS. He also received training in cardiology from Harvard Medical School under Bernard Lown, a Nobel Laureate.,} world renowned Cardiologist and researcher of Ayurveda - member editorial board of J-AIM (Ayurveda Journal), Ex-Vice Chancellor, Manipal Academy of Higher Education.

3). Dr. Bhushan Patavardhan - Director - Interdisciplinary School of Health Sciences, Pune University and the Chief editor of the Journal of Ayurveda and Integrated medicine (J-AIM) - published by Elsevier - link - You may look at the prestigious and distinguished Doctors and Medical science researchers (who review Ayurveda articles and research papers /reports) in the Editorial board of Journal of Ayurveda and Integrative Medicine Editorial Board

4). Dr. G Gangadharan (Ayurvedacharya, FAIP(USA), PhD, MoM (McGill, Canada), Director, Ramaiah Indic SpecialityAyurveda - See more at: Dr.G G Gangadharan at 3rd International Congress on Ayurveda | Rama...- who as part of 22 member Sr. research team proved and published a research on Ayurvedic Prakriti based on Genome-wide Analysis (paper here: Genome-wide analysis correlates Ayurveda Prakriti)

5). Dr. Thelma B.K, who a Human Geneticist and HoD - Dept. of Genetics at University of Delhi and published papers on Ayurgenomics (one paper here Potential of Ayurgenomics Approach in Complex Trait Research: Leads...)

6). NCBI /PubMed (of US Govt) which contains peer reviewed 6000+ research papers and clinical trial reports on Ayurveda system /herbs /formulations (In addition to over 190,000 papers on Complimentary and Alternative medicine)… some links on scientific validations of Ayurvedic formulations and Herbs here (a). Guduchi Inhibition of proinflammatory pathways by bioactive fraction of Tin..., (b). Ashwagandha Comprehensive assessment of the genes involved in withanolide biosy...., (c). Brahmi Bacopa monnieri extract increases rat coronary flow and protects ag..., (d) Various Ayurvedic formulations for Innate anti-oxidant activity (oxidative stress is a main cause of Cancer)Innate antioxidant activity of some traditional formulations., (e). Traditional Ayurvedic Medicines: Pathway to develop anti-cancer drugs: Traditional Ayurvedic medicines: Pathway to develop anti-cancer drugs

7). Nobel Laureate Dr. Tu You You, who won Nobel prize in 2015 for TCM (Traditional Chinese Medicine) - who is now an inspirations to all Alternative medicine researchers - I’m sure the day is not far away where Ayurveda finds total cure for a stain of Cancer or any other life threatening disease without the side effects & costs of the so called modern medicine system and associated widespread international recognition.

8). ICMR-NIMS-Clinical Trials Registry has over 400 clinical trials reports of various Ayurvedic formulations and Drugs - link: Search Result,Clinical Trials Registry - This is for those who say there is no scientific basis for Ayurveda !.

9). Clinical trials in Ayurvedic Drugs /Reverse Pharmacology method: This is about why we shouldn’t be harping only on Clinical trials for Ayurveda https://www.researchgate.net/pub...

10). NIMHANS (National Institute of Mental Health and Neurosciences) Ayurvedic centerAdvanced Centre for Ayurveda

11). Manipal University A multi-centric project supported by the AYUSH Foundation and DST, Govt. of India, this program deals with understanding the underlying scientific principles of Ayurveda, an Indian traditional medicine. Work carried out in our labs is focused on deciphering possible molecular (genetic and epigenetic), metabolic and biochemical clues to the various Prakriti classifications of Ayurveda, as well as its treatment modalities for quality ageing, improving mental abilities etc. Science initiatives in Ayurveda

12). What Doctors Don't Get to Study in Medical School - by Dr. B. M. Hegde, This is not a textbook as the author says but, in my opinion, this is a "Holy Text" of medicine and is a must read for everyone who deals with sickness. Richard Smith, MD, FRCP Former Editor, British Medical Journal, London. Here, laid out clearly and concisely, are all the well-established potholes and pitfalls in current medical thinking and practice. It is a thought provoking challenge to modern medical practice and research. Dr Hegde confronts the issue, and proposes an alternative humanistic attitude to education and treatment. Drawing on a huge range of resources from Sanskrit texts, Green and European philosophers, ancient and modern healers, to the most up-to-date Western research and publications. He has written a book that is both scholarly yet easy to read, and which will appeal to everyone involved in medicine whether students, practitioners or patients

This book provides part of the important and formative reading a medical student must do outside the prescribed requirements for a degree, and is also equally valuable to qualified practitioners and medical professionals. Here, laid out clearly and concisely, are all the well-established potholes and pitfalls in current medical thinking and practice. It is a thought provoking challenge to modern medical practice and research and is intended to encourage us to consider the way medicine is taught. Modern medical practices are driven by science, technology and consumerism, with the cost of treatment weighted in favour of the doctor rather than to the benefit of the patient. What Doctors Don't Get to Study in Medical School

Q: Is there any harm in rejecting scientific evidence?

Krishna: Yes, hundred percent. Shall I provide examples?

A  study by Harvard researchers ( researchers-estimate-lives-lost-delay-arv-drug-use-hivaids-south-af...  and https://www.ncbi.nlm.nih.gov/pubmed/19186354  )

 estimates that the South African government would have prevented the premature deaths of 365,000 people earlier this decade if it had provided antiretroviral drugs to AIDS patients and widely administered drugs to help prevent pregnant women from infecting their babies.

The Harvard study concluded that the policies grew out of President Thabo Mbeki's  denial of the well-established scientific consensus about the viral cause of AIDS and the essential role of antiretroviral drugs in treating it.

Similarly the growing “anti-vaxxer” movement is extremely harmful to innocent children who are falling pray to various diseases despite the availability of vaccines to prevent them.

You have your right to disagree with scientific consensus only up to a point. If your disagreement is causing harm to the society, that right should be taken away from you. 

Q: Why do scientists like you also seem to have general knowledge in the humanities?

Krishna: I am interested in several things and want to learn about them as much as possible.

So I am an artist, a writer, a poet, a designer, a network creator, a social activist and deal with several things apart from science.

I use humanities to communicate science effectively.

Well scientists are human beings first and they would naturally be interested in human cultures they were born into. And everything associated with humanity interests them too. If they can use these things for the advancement of their subject as well as bringing together various subjects for mutual benefits that is the peak of human intelligence.  

Q: Why does the public like to favour heroes instead of scientists?

Krishna: Film heroes are easy to understand than scientists for the general public.

Majority of the people don’t want to burden their brains with complex maths, statistics and scientific theories, when they can easily enjoy life by getting into a dream world, feel happy about heroics, super dialogues, songs and dances of a hero.

People cannot relate to science and scientists the way they can relate to films and heroes.

The media plays favourites too. It promotes movies more than science and film heroes more than scientists.

However,

The enchanting charms of sublime science reveal only to those who have the courage to go deeply into it - Carl Friedrich Gauss

Unfortunately several people are missing the beauty and thrills of science by avoiding it and seeking the easy way out to go through life.

Q: Scientists are the most intelligent people on our planet. They are capable of thinking clearly and taking good decisions. Yet, why do some people want to impose restrictions on their work in the name of ethics?

Krishna: Good question.

But scientists are human beings too. They can come under religious, political and emotional pressures. And there is no international body to keep an eye on their work. Public fear this aspect.

In such situations general public and the media have greater roles to play to guide politicians and religious leaders. But can a person outside the scientific arena understand fully the implications of a research work  like a scientist does? NO!

For example consider the field of Synthetic Biology - you can use the knowledge to make both designer babies and cure diseases. While fear about the first one is making politicians, religious and some members of general public (like activists) to oppose it, scientists  say it is necessary to conduct research that goes beyond a limit in the field to find answers to human suffering. 

Who has the right to decide here? Obviously the people who fund such research i.e., those that are outside science -  like politicians (Governments and business people that are influenced by religious leaders) can make a huge impact by cutting the money flow. Who suffers? The General public themselves. 

You might fear about a bad outcome. But that shouldn't make you stop good progress. Partial Picture Paralysis of the people outside of scientific research is the reason for all this mess.

Like several scientists are accepting now, we need a revamp of these ethical guidelines and it must come from the scientific community itself.

Q: What is the importance of different types of science?

Krishna: Although there are different subjects in science, in today’s world, they are all being interlinked by scientists to creatively solve the problems humanity is facing.

So in basic science, we have several subjects that deal with basics of each subject. This is important in understanding the subject properly.

In applied sciences, the boundaries somewhat blur and creative-connecting of the knowledge acquired in various areas becomes vital.

 

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