Comment

Comment by Dr. Krishna Kumari Challa 9 hours ago

Overactive Neurons Cause Excessive Sweating

Identification of gene variants that affect the activity of neuronal sodium channels could help develop targeted therapies for patients suffering from excessive sweating.
Sweating is a normal, although sometimes unpleasant, part of being human. For people with primary idiopathic hyperhidrosis (PIH), though, excessive sweating can impede their quality of life. Despite affecting up to five percent of people, though, scientists don’t fully understand the mechanisms behind this overactive salty secretion.

Researchers have found that some patients have alterations to their sweat glands’ morphology or function, possibly contributing to the extra sweating. But for people who sweat excessively despite having normal looking sweat glands, scientists suspect that the cause could be hyperactive sympathetic neurons.
In a study published recently in Science Advances, researchers dug into the genetic sequences of 32 families with confirmed PIH to find possible sources of overactive sweat responses. They identified a lead candidate in SCN10A, a gene encoding a sodium channel in sympathetic neurons and discovered that introducing it into mice reproduced the extra sweating phenotype of PIH individuals. They showed how their mouse model of PIH could be used to explore new treatment options for patients.
For decades, hyperhidrosis has largely been viewed as a disorder of the sweat glands. These new findings show that, for some patients, the problem actually begins in the nerves that control sweating, providing a biological explanation for the condition and a potential pathway to more effective treatments.

1. Wohlrab J, et al. Hyperhidrosis: A central nervous dysfunction of sweat secretion. Dermatol Ther. 2023;13(2):453-463.
2. Yamauchi S, et al. A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype o.... Sci Adv. 2026;12(29):aed3221.

Comment by Dr. Krishna Kumari Challa 10 hours ago

Leaky gut might make food allergies worse

A "leaky gut" might increase the severity of food allergies, according to new research conducted in mice and published in The Journal of Immunology. The researchers found that changes to the gut microbiome in mice were linked to increased intestinal permeability (leaky gut) and increased food allergy severity.

Intestinal permeability describes how the intestines move water and nutrients from food into the bloodstream. Increased permeability, sometimes called "leaky gut," describes a condition in which damage to the gut lining allows partially digested food, toxins or germs to pass into the bloodstream.

The gut microbiome—the trillions of bacteria living in the gut—directly regulates this barrier, meaning microbiome imbalances can be a primary driver of gut leakage.
In mice, distinct gut microbiomes were associated with differing intestinal permeability, Th2/Treg balance, and food allergy severity. Cohousing transferred microbiota from severely affected mice to mildly affected mice, increasing intestinal permeability and worsening allergic responses. Data indicate gut microbes modulate barrier function and food-allergy–specific immune cells.
In this study, the researchers used two groups of mice known to have differences in their gut microbiomes. When a food allergy was induced in the mice, one group developed mild allergic reactions (less diarrhea), while the other had more severe reactions. The mice with more severe diarrhea were also known to have increased intestinal permeability, or "leaky gut."

In mice with more severe food allergies, the researchers also observed an increase in immune cells that cause allergic reactions, Th2 cells, and a decrease in food-allergy-specific immune cells that turn off immune responses, Treg cells. Th2 cells are the immune cells that cause anaphylaxis in people with food allergies.
Interestingly, when the researchers housed mice from the two groups together, they found that mice with milder food allergies developed more severe symptoms. Further tests uncovered that the gut microbiome of the mice with milder allergic reactions shifted to be more like that of the group with severe reactions. The researchers also reported increased intestinal permeability and a change in the balance of immune cells involved in the food allergy response, suggesting that "leaky gut" and the gut microbiome are linked to how the immune system responds to a food allergy.
Researchers clearly saw that food-allergy-specific immune cells were impacted by gut microbes, which affected the food allergy itself.

Journal of Immunology (2026). DOI: 10.1093/jimmun/vkag172

Comment by Dr. Krishna Kumari Challa 11 hours ago

Not all exercise is equal when it comes to metabolic syndrome risk
Exercise modalities showed distinct effects on metabolic syndrome markers. Aerobic plus resistance training improved waist circumference, BMI, LDL cholesterol and glycemic control; mind-body exercise improved HDL cholesterol and systolic blood pressure; high- and low-volume HIIT preferentially reduced body fat and lipids or diastolic pressure, respectively. Evidence certainty was generally low.

Xinyu Shen et al, Comparative efficacy of various exercise therapies for metabolic syndrome a systematic review and network meta-analysis, iScience (2026). DOI: 10.1016/j.isci.2026.116801

Comment by Dr. Krishna Kumari Challa 11 hours ago

Bacteria build a mineral shield that could help marine infrastructure resist rust

Researchers have developed a biological method for protecting marine infrastructure from corrosion caused by prolonged exposure to seawater. The study, published in Cell Reports Physical Science, presents an environmentally friendly alternative to the chemical corrosion inhibitors currently used to protect metals—materials that can be both polluting and costly.
The researchers discovered that these bacteria work cooperatively to form a dense, durable and naturally occurring protective layer on the surfaces of metals commonly used in marine and electrochemical infrastructure, including steel and iron.

Experiments conducted as part of the study demonstrated that this protective coating significantly slows the corrosion process that causes metals to rust and deteriorate in seawater. The researchers also found that each bacterial species plays a distinct role: Some create the conditions necessary for the process, while others produce an enzyme that enables the formation of the mineral protective layer.
A seawater-derived bacterial consortium, including Bacillus subtilis, forms a dense mineralized biofilm on steel and iron that markedly slows marine corrosion. Different species fulfill complementary roles in conditioning the surface and producing enzymes that drive mineral layer formation. Multispecies communities provide more robust, long-term protection than single strains, offering a potential low-toxicity alternative to chemical corrosion inhibitors.

Avichay Nahami et al, Synthetic bacterial communities as synergistic anti-corrosion agents, Cell Reports Physical Science (2026). DOI: 10.1016/j.xcrp.2026.103419

Comment by Dr. Krishna Kumari Challa 11 hours ago

Fission creates more mitochondria As a first step in their experiments, scientists infected mouse macrophages with E. coli and found that the number of mitochondria increased, a direct result of fission. The fission, in this instance, was induced in response to E. coli infection. Then, with the help of a cocktail of compounds and the silencing of a gene involved in fission, scientists wanted to see what would happen if the organelles were directed toward mitochondrial fusion—the opposite pathway of fission. The result was increased intracellular E. coli in the macrophages. Still, the lesson learned from E. coli was not universal, and there apparently are significant differences in mitochondrial immune reactions from one pathogen to another. With Salmonella typhimurium, for example, researchers found that the pathogen survives inside macrophages and orchestrates mitochondrial behavior to the benefit of the bacteria, preventing mitochondrial fission and the substantial increase in additional mitochondria. But researchers had an answer to the craftiness of Salmonella typhimurium: Inhibiting the enzyme HDAC6 promoted mitochondrial fission and lipid droplet formation, enhancing bacterial clearance—and suggesting that HDAC6 could be a therapeutic target to control otherwise recalcitrant infections.

Ronan Kapetanovic et al, Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response, Science Immunology (2026). DOI: 10.1126/sciimmunol.aed2623

Part 2

Comment by Dr. Krishna Kumari Challa 11 hours ago

Mitochondria: Scientists uncover new role for fighting bacterial infections, including drug-resistant superbugs

Mitochondria: They are the engines of cellular energy production; they possess their own DNA, and they are passed from generation to generation from mothers to offspring.

Now scientists have revealed that these bean-shaped energy factories, known for the production of ATP, the key fuel of life, also play an extraordinary role in harnessing the immune response during infection—these organelles are critical in mediating a powerful antibacterial defense.

The discovery demonstrates an unexpected role for these crucial constituents of cells. The team showed that mitochondrial fission underlies an immune response, producing antibacterial capability in a host of organisms from the lowly worm to complex mammals.

The findings suggest that mitochondrial fission is an evolutionarily conserved pathway that provides cell-autonomous control of infection and can be targeted to combat antibiotic-resistant bacterial pathogens.

Mitochondrial division—or fission—can promote antibacterial defense pathways in mammalian macrophages and worms, according to the study, which identified the regulatory mechanisms that control these defense pathways. Findings from the research could inform future therapeutic targets while highlighting unique mitochondrial functions in the fight against infection.

Part 1

Comment by Dr. Krishna Kumari Challa yesterday

Phage and microbiota therapy reduced recurrent UTIs in two patients over two years
Combined phage therapy and fecal microbiota transplantation were administered to three women with antibiotic-refractory recurrent E. coli UTIs. Treatment was well tolerated. Over two years, the two patients receiving both phage therapy and FMT showed sustained reduction of UTIs and antibiotic use, while phage therapy alone led to continued but milder episodes.

https://www.nature.com/articles/s41564-026-02409-0

---

Cancer drug enables kidney transplant despite severe immune incompatibility
A single dialysis-dependent patient with complete HLA sensitization (cPRA 100%) received teclistamab, a myeloma drug targeting antibody-producing cells, for 31 weeks, leading to marked, sustained reduction of anti-HLA antibodies and eventual successful kidney transplantation with excellent graft function. The case suggests teclistamab may enable transplantation in highly sensitized candidates and potentially in xenotransplantation or ABO-incompatible and other organ transplants, but systematic evaluation of efficacy and safety is still required.

Comment by Dr. Krishna Kumari Challa yesterday

Invasive species emerge as a driver of human displacement, new research shows
Invasive alien species degrade ecosystems, erode food and livelihood security, and act as a direct driver of forced human displacement. Case examples include Opuntia stricta in Kenya, little fire ants in Pacific islands, and water hyacinth in African fisheries. Biological invasions are rarely integrated into migration or sustainability science, and the paper urges their inclusion in international indicators and policy on displacement and land degradation.
The new study argues that biological invasions can erode natural resources vital to human security, forcing communities to abandon their land and livelihoods. Despite these impacts, the link between invasive species and human displacement has received little attention.
Researchers call for stronger international action to address this issue.

Reaser JK and Witt ABR (2026) Invasive alien species are drivers of human displacement: recommendations for a multilateral mitigation framework. Front. Conserv. Sci. 7:1858063. doi: 10.3389/fcosc.2026.1858063

https://www.frontiersin.org/journals/conservation-science/articles/...

Comment by Dr. Krishna Kumari Challa yesterday

Discovery of a multicomponent alloy forged by the Hiroshima atomic blast

High-energy nuclear detonations generate extreme, transient physicochemical environments capable of producing previously unknown materials. We report the discovery of a previously unknown multicomponent alloy preserved within a hiroshimaite spherule recovered from beach sands of Hiroshima Bay, formed during the 6 August 1945 atomic airburst. The micrometer-sized metallic grain occurs within a quenched glassy matrix. Electron microprobe analyses reveal a homogeneous, Si-rich multielement composition (Fe-Cr-Ni-Mn-Mo-Si-Al). Single-crystal x-ray diffraction shows that the phase crystallizes in space group P213 with the ordered AlAu4-type structure, an ordered derivative of β-Mn. The alloy likely formed by condensation from a mixed metallic vapor followed by ultrafast quenching in the expanding fireball. This finding demonstrates that nuclear plasma events may stabilize complex metallic phases and highlights atomic-blast debris as a natural laboratory for nonequilibrium alloy formation and materials discovery.

https://www.science.org/doi/10.1126/sciadv.aeg8299

Comment by Dr. Krishna Kumari Challa yesterday

“Innovation without access is not an innovation… it is an injustice.”

• ‹ Previous
• 1
• 2
• 3
• …
• 1273
• Next ›
• Page