Science, Art, Litt, Science based Art & Science Communication
All about Science - to remove misconceptions and encourage scientific temper
Communicating science to the common people
'To make them see the world differently through the beautiful lense of science'
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WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING
THIS IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS
“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”
"Being a scientist is a state of mind, not a profession!"
"Science, when it's done right, can yield amazing things".
"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.
Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.
If you are scientifically literate the world looks very different to you.
We do science and science communication not because they are easy but because they are difficult!
“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"
There are about 1052 articles posted here in this group. Links to some important articles :
1. Interactive science series...
a. how-to-do-research-and-write-research-papers-part 13
b. Some Qs people asked me on science and my replies to them...
Part 6, part-10, part-11, part-12, part 14 , part- 8,
part- 1, part-2, part-4, part-5, part-16, part-17, part-18 , part-19 , part-20
part-21 , part-22, part-23, part-24, part-25, part-26, part-27 , part-28
part-29, part-30, part-31, part-32, part-33, part-34, part-35, part-36, part-37,
part-38, part-40, part-41, part-42, part-43, part-44, part-45, part-46, part-47
Part 48, part49, Critical thinking -part 50 , part -51, part-52, part-53
part-54, part-55, part-57, part-58, part-59, part-60, part-61, part-62, part-63
part 64, part-65, part-66, part-67, part-68, part 69, part-70 part-71, part-73 ...
BP variations during pregnancy part-72
who is responsible for the gender of their children - a man or a woman -part-56
c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7
e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9
f. why astrology is pseudo-science part 15
g. How Science is demolishing patriarchal ideas - part-39
2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes
3. Science communication series:
a. science-communication - part 1
b. how-scienitsts-should-communicate-with-laymen - part 2
c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3
d. the-importance-of-science-communication-through-art- part 4
e. why-science-communication-is-geting worse - part 5
f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6
g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7
h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8
i. science-writers-and-communicators-where-are-you - part 9
j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10
k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11
l. golden-rules-of-science-communication- Part 12
m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13
n. an-informed-patient-is-the-most-cooperative-one -part 14
o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15
p. the-most-difficult-part-of-science-communication - part 16
q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17
r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18
u. art-and-literature-as-effective-aids-in-science-communication-and teaching
v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them
y. sci-com: why-keep-a-dog-and-bark-yourself
z. How to deal with sci com dilemmas?
4. Health related topics:
p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!
r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine
u. allergic- agony-caused-by-caterpillars-and-moths
26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?
32. Science and trust series:
You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum
( Please go through the comments section below to find reports/research results relating to science reported on a daily basis and watch videos based on science)
Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.
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Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 18 hours ago. 1 Reply 0 Likes
When a heart stops beating, blood stops flowing and delivering oxygen to the brain (hypoxia) and other vital organs (ischemia). There is a small window (about 4 minutes) before the lack of blood flow…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 3 Replies 0 Likes
Comedian Robin Williams had been diagnosed with several health conditions before he committed suicide last year, according to his widow. He was "just disintegrating" physically and mentally in the…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Thursday. 1 Reply 0 Likes
Any new find or discovery usually makes scientists elated. But this one made them distressed. Find out why ....'Disturbing' find on remote island: plastic rocks…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Tuesday. 1 Reply 0 Likes
Q: Is witchcraft used to conjure up supernatural effects or is it just superstition?Krishna: Witchcraft is superstition, pure and simple!No two things could be further apart, seemingly, than…Continue
It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery—until possibly now. The key may lie in an epigenetic regulator that boosts the activity of specialized anti-viral immune cells known as natural killer (NK) cells.
In a study published March 16 in the peer-reviewed journal Nature Immunology, a collaborative team of researchers have found that female mouse and human NK cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function, while repressing NK cell numbers.
While it is well-known that males have more NK cells compared to females, researchers did not understand why the increased number of NK cells was not more protective during viral infections. It turns out that females have more UTX in their NK cells than do males, which allows them to fight viral infections more efficiently.
The researchers noted that this held true whether or not the mice had gonads (ovaries in females; testes in males), indicating that the observed trait was not linked to hormones. Furthermore, female mice with lower UTX expression had more NK cells which were not as capable of controlling viral infection.
This implicates UTX as a critical molecular determinant of sex differences in NK cells.
The findings suggest that therapies involving immune responses need to move beyond a "one-size-fits-all" approach and toward a precision medicine model, also known as personalized medicine, that tailors treatments that take into account people's individual differences, such as genetics, environment and other factors that influence health and disease risk, the researchers write.
Mandy I. Cheng et al, The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences, Nature Immunology (2023). DOI: 10.1038/s41590-023-01463-8
The authors discuss some limitations of their study. The findings' generalizability to soccer players playing today is uncertain. As neurodegenerative disease usually occurs later in life, most players in the study who were old enough to have developed one of these conditions played elite soccer during the mid-20th century. Since then, soccer has changed in many ways that may impact the risk of neurodegenerative disease. It may be that switching from leather to synthetic balls (that do not soak up water and become heavier), having more rigorous training and better equipment, or switching towards a playstyle associated with less head trauma may have reduced the risk. On the other hand, the risk might be higher among soccer players who nowadays train and play more intensely from a young age. The study also looked at male elite soccer players only, so the study's generalizability to female elite players and to male and female amateur and youth players is uncertain.
Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study, The Lancet Public Health (2023). DOI: 10.1016/S2468-2667(23)00027-0 , www.thelancet.com/journals/lan … (23)00027-0/fulltext
Elite male soccer players were 1.5 times more likely to develop neurodegenerative disease than population controls, according to an observational study published in The Lancet Public Health journal.
Among male soccer players playing in the Swedish top division, 9% (537 out of 6,007) were diagnosed with neurodegenerative disease, compared to 6% (3,485 out of 56,168) population controls.
The soccer players were both amateur and professional. Sweden was a prominent soccer nation during the 20th century and many of the players from the top division were competing at the highest international level. However, due to ideals of sportsmanship and amateurism, soccer clubs in Sweden were not allowed to pay salaries to their soccer players until the late 1960s.
In recent years, there have been growing concerns about exposure to head trauma in soccer (soccer) and whether it can lead to increased risk of neurodegenerative disease later in life. A previous study from Scotland suggested that soccer players were 3.5 times more likely to develop neurodegenerative disease. Following this evidence, certain footballing associations implemented measures to reduce heading in younger age groups and training settings.
While the risk increase in this study is slightly smaller than in the previous study from Scotland, it confirms that elite [soccer players] have a greater risk of neurogenerative disease later in life. As there are growing calls from within the sport for greater measures to protect brain health, this new study adds to the limited evidence base and can be used to guide decisions on how to manage these risks.
The authors caution that although 9% of soccer players and 6% of controls were diagnosed with neurodegenerative disease during their study, most participants were still alive at the end of data collection, so the lifetime risks of developing neurodegenerative disease for both groups are likely to be higher.
The risk of neurodegenerative disease was 1.5 times higher for outfield players than controls but was not significantly higher for goalkeepers compared to controls. Accordingly, in a direct comparison, outfield players had a risk of neurodegenerative disease 1.4 times higher than that of goalkeepers.
Soccer players had a risk of Alzheimer's disease and other dementias 1.6 times that of controls—with 8% (491 out of 6,007) of soccer players being diagnosed with the condition compared to 5% (2889 out of 56,168) of controls.
A ball, a saddle, or a flat plate. The curvature of biomaterials inhibits or stimulates bone cells to make new tissue. This is what TU Delft engineers show in research published in Nature Communications. This study of geometries could be an important step in research into repairing damaged tissues. In this video, Amir Zadspoor (professor of Biomaterials and Tissue Biomechanics) and Lidy Fratila-Apachitei (assistant professor of Biomaterials) explain exactly how this new tool for organ repair works.
Casting light on counterfeit products through nano-optical technology
Each year, an estimated two trillion dollars is lost globally due to counterfeit products ranging from jewelry to medicine. As current security labels and product authentication methods are rapidly becoming obsolete or easy to hack, there is a rising urgency for more secure anti-counterfeiting labels.
A research team fabricated a 3D printed nano optical security label that provides 33100 possible combinations for heightened security in optical anti-counterfeiting.
The research team achieved such a feat by exploiting higher dimensional structured light, i.e., colored Orbital Angular Momentum (OAM) beams, through the fabrication of 3D printed spiral phase plates. Importantly, these plates were miniaturized down to a diameter smaller than that of a strand of human hair and further integrated with structural color filters—spiky looking structures that allow specific colors of light through.
In their study, they included color, spatial position, and OAM of light (one degree of freedom of light) onto a small colored vortex beam (CVB) generator (25 μm). With only 10-by-10 CVB unit array to demonstrate, the optical security label they designed could open pathways for the next generation of optical anti-counterfeiting.
We see things clearly when we hold them up to the light. What this team has done is to learn how to use the natural light that surrounds us and extract tiny beams from it that carry information encoded in not just color, but also by how much we 'twist' its wavefront. This optical version of the combination lock that utilizes high-dimensional structured light provides us with a powerful platform for advanced anti-counterfeiting and information security.
Casting light on counterfeit products through nano-optical technology (2023, March 14)
retrieved 18 March 2023 from https://phys.org/news/2023-03-counterfeit-products-nano-opticaltech...
The video shows the optical security label or photonic tally, consisting of colored vortex beam array. The photonic tally turns into colorful dots when overlapped with each other. During this process, the color and OAM (orbital angular momentum) information is decoded. Credit: Singapore University of Technology and Design
Intracerebral hemorrhage, and bleeding into the brain tissue, is a devastating neurological condition affecting millions of people annually. It has a high mortality rate, while survivors are affected by long-term neurological deficits. No medication has been found to support brain recovery following hemorrhage.
In an international collaboration, researchers investigated whether a protein called cerebral dopamine neurotrophic factor (CDNF) has potential as a treatment for brain hemorrhage.
Researchers suggest that cerebral dopamine neurotrophic factor, a protein being currently tested for Parkinson's disease treatment, also has therapeutic effects and enhances immune cell's response after brain hemorrhage.
The authors found that the administration of cerebral dopamine neurotrophic factor accelerates hemorrhagic lesion resolution, reduces brain swelling, and improves functional outcomes in an animal model of brain hemorrhage.
They found that found that cerebral dopamine neurotrophic factor acts on immune cells in the bleeding brain, by increasing anti-inﬂammatory mediators and suppressing the production of the pro-inﬂammatory cytokines that are responsible for cell signaling. This is a significant step towards the treatment of injuries caused by brain hemorrhage, for which we currently have no cure.
The administration of cerebral dopamine neurotrophic factor also resulted in the alleviation of cell stress in the area that surrounds the hematoma.
Finally, the researchers demonstrated that systemic administration of cerebral dopamine neurotrophic factor promotes scavenging by the brain's immune cells after brain hemorrhage and has beneﬁcial effects in an animal model of brain hemorrhage.
Kuan-Yin Tseng et al, Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage, Cell Death & Disease (2023). DOI: 10.1038/s41419-022-05520-2
New research makes it likely that proteins responsible for activating mosquito sperm can be shut down, preventing them from swimming to or fertilizing eggs.
The study could help control populations of Culex, the common house mosquito that transmits brain-swelling encephalitis and West Nile Virus.
During mating, mosquitoes couple tail to tail, and the males transfer sperm into the female reproductive tract. It can be stored there awhile, but it still has to get from point A to point B to complete fertilization.
Key to completing that journey are the specialized proteins secreted during ejaculation that activate the sperm flagella, or 'tails,' that power their movement.
Without these proteins, the sperm cannot penetrate the eggs. They'll remain immotile, and will eventually just degrade.
The study, detailed in the journal PLOS ONE, details a full portrait of all the proteins in the insect's sperm, allowing researchers to find the specific ones that maintain the quality of the sperm while they're inactive, and that also activate them to swim.
To get this detailed information the researchers worked with a team of graduate and undergraduate students who isolated as many as 200 male mosquitoes from a larger population. They then extracted enough sperm from the tiny reproductive tracts for mass spectrometry equipment to detect and identify the proteins.
Previously, the team determined that sperm need calcium upon entering a reproductive tract to power forward motion. They can now look in the completed protein profile they've created, find the calcium channel proteins, and design experiments to target these channels.
This kind of protein profiling offers a path toward controlling mosquitoes that is more environmentally friendly than other methods that can have unintended, toxic effects.
This work sets the foundation for a form of biological control, which most would agree is preferable.
The operative word is control, rather than eradicate. Even though immobilizing the sperm would be 100% effective for the treated mosquitoes, it is not possible or desirable to kill all mosquitoes. This technology would change the proportion of fertile to infertile males in a given mosquito population, rather than wiping them all out.
The team is hoping that information about sperm motility regulators in Culex will also apply to other species of mosquitoes. And other pests too! What we learn in one system, such as mosquitoes, can translate to others.
Catherine D. Thaler et al, Using the Culex pipiens sperm proteome to identify elements essential for mosquito reproduction, PLOS ONE (2023). DOI: 10.1371/journal.pone.0280013
Although mRNA vaccines have dominated the U.S. response to the pandemic, the technology underlying those shots is expensive. The finicky, temperature-sensitive ingredients required for mRNA vaccines may be difficult to store in far-flung regions of the globe. To address the global need for a low-cost vaccine that can be produced locally, scientists have been developing alternatives, such as NDV-HXP-S.
The vaccine's initials, NDV-HXP-S, stand for Newcastle disease virus, HexaPro, and spike protein. Producing the vaccine involves a vector, which in this case is the Newcastle disease virus, an agent that infects birds. The vaccine is manufactured by way of egg-based technology, which has been used for decades to produce annual flu shots. The Newcastle viral vector is not used in the production of influenza vaccines.
The vector works exquisitely well in the NDV-HXP-S production process, ferrying vaccine components into embryonated chicken eggs. The result, in the case of the vaccine used in Thailand, is an inactivated vaccine, which is a viral particle displaying SARS-C0V-2's spike protein on its surface.
"NDV-HXP-S can be used as a live vaccine or as an inactivated vaccine
The team analyzed antibody responses after Thai volunteers were vaccinated in the phase 1 clinical study. Researchers studied serum samples from 210 Thai volunteers who received either a placebo or the inactivated NDV-HXP-S vaccine.
They compared antibodies from the Thai volunteers to those from 20 people who received the Pfizer mRNA vaccine in New York City. Antibodies elicited by NDV-HXP-S tended to target the receptor binding domain of the virus rather than the spike protein's S2 subunit, the researchers found.
"Neutralizing activity of sera from NDV-HXP-S vaccinees was comparable to that of [Pfizer] vaccinees, whereas spike protein binding activity of the NDV-HXP-S vaccinee samples was lower than that of sera obtained from mRNA vaccines," the researchers say. This led them to calculate ratios between binding and neutralizing antibody titers.
This work show that a vaccine candidate that can be produced locally in [low- and middle-income countries] at low-cost induces neutralizing antibody titers to SARS-CoV-2 comparable to those observed in cohorts having received mRNA-based COVID-19 vaccines.
Juan Manuel Carreño et al, An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination, Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.abo2847
An experimental COVID-19 vaccine produced with technology based on a decades-old method, elicited virus-neutralizing antibodies in higher proportion than the amount induced by mRNA immunizations, a Phase 1 clinical trial has found.
The investigational vaccine was developed in New York City and tested in Thailand where the shots were produced using a form of egg-based technology. The fact that researchers are still racing to develop new COVID-19 vaccines highlights an ongoing need, especially in low- and middle-income countries—and for good reason.
There is a need for SARS-CoV-2 vaccines that can be produced at low cost locally in low- and middle-income countries and this is one such experiment.
The study analyzed antibody responses elicited by the investigational vaccine known as NDV-HXP-S, which is produced in hens' eggs.
The research found that the investigational vaccine prompted a higher proportion of neutralizing antibodies against SARS-CoV-2 in volunteers compared with the proportion of neutralizing antibodies produced by a separate group of people who were vaccinated with Pfizer's mRNA vaccine.
A neutralizing antibody is one that defends healthy cells from a virus by neutralizing the pathogen's efforts to get inside. For instance, a neutralizing antibody can stop a virus from making a conformational change—swapping its structure for a new shape. Viral shape-shifting is a way to infect a cell.
Neutralizing antibodies differ from binding antibodies, which latch onto the pathogen and alert warrior cells of the immune system that a viral invasion is underway. While people who were vaccinated with NDV-HXP-S had a higher proportion of neutralizing antibodies, their binding to neutralizing antibody ratios were lower than those who were vaccinated with Pfizer's mRNA vaccine. When all variables were taken into account, the team concluded that the antibody responses between the two vaccines were comparable.
Findings from the research suggest that even in regions with previously limited vaccine-production infrastructure, it's possible to manufacture robust COVID shots at low cost. Western countries averse to technology sharing early in the pandemic, a factor that left scores of people in low- and middle-income countries with few opportunities for vaccination. Now, the tide is turning, albeit three years after the global SARS-CoV-2 pandemic was declared.
"Locally produced vaccines can increase vaccine access and vaccine independence, especially for low- and middle-income countries. The NDV-HXP-S vaccine is designed to help close this gap because it can be economically produced in influenza vaccine manufacturing plants that are located in [these countries]. Moreover, it can be stored and distributed without the need for freezers.
Water makes up 71% of Earth's surface, but no one knows how or when such massive quantities of water arrived on Earth.
A new study published in the journal Nature brings scientists one step closer to answering that question.
Researchers analyzed melted meteorites that had been floating around in space since the solar system's formation 4 1/2 billion years ago. They found that these meteorites had extremely low water content—in fact, they were among the driest extraterrestrial materials ever measured. These results, which let researchers rule them out as the primary source of Earth's water, could have important implications for the search for water—and life—on other planets. It also helps researchers understand the unlikely conditions that aligned to make Earth a habitable planet.
After analyzing the achondrite meteorite samples, researchers discovered that water comprised less than two millionths of their mass. For comparison, the wettest meteorites—a group called carbonaceous chondrites—contain up to about 20% of water by weight, or 100,000 times more than the meteorite samples.
This means that the heating and melting of planetesimals leads to near-total water loss, regardless of where these planetesimals originated in the solar system and how much water they started out with. Researchers discovered that, contrary to popular belief, not all outer solar system objects are rich in water. This led them to conclude that water was likely delivered to Earth via unmelted, or chondritic, meteorites.
Megan Newcombe, Degassing of early-formed planetesimals restricted water delivery to Earth, Nature (2023). DOI: 10.1038/s41586-023-05721-5. www.nature.com/articles/s41586-023-05721-5
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