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Comment by Dr. Krishna Kumari Challa 14 hours ago

Estrogen-like mold toxins linked to corn products found in all pregnant participants in small pilot study

Consuming common foods such as corn chips and popcorn may put pregnant women at risk of exposure to mycotoxins—harmful substances produced by mold—according to researchers.

Their study, published in the Journal of Exposure Science & Environmental Epidemiology, found hormone-mimicking mycotoxins in 100% of participants and linked exposure levels to the amount of corn and grain products consumed.
A pilot study of 33 pregnant women detected at least one estrogenic mycotoxin in every urine sample, with zearalenone present in most samples and indicating persistent exposure. Higher urinary mycoestrogen levels were strongly associated with recent intake of corn and other grain products, especially corn-based foods, and were higher among Hispanic participants, who reported greater corn and dairy consumption.
One such mycotoxin is zearalenone, a compound produced by Fusarium fungi that contaminate staple crops such as corn, wheat and oats. Zearalenone can indirectly enter human food supplies through meat and dairy from animals that eat contaminated feed. It is also heat-stable, so it can survive cooking and food processing.

Because zearalenone can mimic estrogen, a hormone critical to pregnancy and fetal development, it is more specifically classified as a mycoestrogen. Other studies suggest that exposure to mycoestrogens may contribute to greater gestational weight gain and lower infant birth weight.
The research findings confirm that grain-based foods are important contributors to mycoestrogen exposure among pregnant women.
Researchers found that consumption of corn and other grain products in the 24 hours before a urine sample was collected was strongly associated with higher mycoestrogen levels.

Corn-based foods, including corn, corn chips and corn tortillas, showed the strongest associations, followed by more modest links to cereal grains and oils. By contrast, consumption of chicken and pork showed weaker, inverse associations, suggesting corn and grain products, rather than meat, were the primary dietary contributors to exposure in this study group.

Zorimar Rivera-Núñez et al, Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study, Journal of Exposure Science & Environmental Epidemiology (2026). DOI: 10.1038/s41370-026-00940-0

Comment by Dr. Krishna Kumari Challa 15 hours ago

Sudden cardiac death condition shown to have linked genetic variations

Scientists have found that the "sudden" cardiac death condition related to high-profile deaths or major medical episodes of sports stars including Fabrice Muamba, Christian Erikson and Mark-Vivian Foe, has numerous linked gene variations that highlight a potentially treatable vulnerability.
In a study published in Nature Communications, a multi-disciplinary team of researchers have uncovered new insights into how "spelling mistakes" in our DNA contribute to hypertrophic cardiomyopathy (HCM), a leading cause of sudden cardiac death worldwide.

"Spelling mistakes" in a protein called alpha-actinin-2 or ACTN2 have previously been identified for their role in the disease, but they have not addressed how these errors lead to cardiac arrest. This study found that 17 of the spelling mistakes in ACTN2 are linked to HCM, and that they affected the protein in different ways.
In the study, structural and cell biologists teamed up to investigate 17 mistakes in ACTN2 using a range of experimental methods and found that they affect the protein in several different ways. Some errors made the protein less stable, more likely to clump together, or less able to interact with other molecules.

Researchers have also found that these spelling mistakes have different effects depending on where they are located within ACTN2. In particular, a critical region called the Actin Binding Domain (ABD), which helps ACTN2 interact with other parts of cells and is important for major cell processes, was identified as a key hotspot for changes caused by these spelling mistakes.
The findings will help us and other researchers worldwide to find potential ways to address these genetic weaknesses and better understand how these proteins are literally reshaping the hearts of people with this condition.

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy, Nature Communications (2026). DOI: 10.1038/s41467-026-75392-z

Comment by Dr. Krishna Kumari Challa 16 hours ago

Ripples of activity in the hippocampus prepare the brain for surprising events

The human brain continuously makes predictions about future events. This process helps humans process familiar stimuli while also allowing them to direct particular attention to unexpected or unfamiliar events and derive important new information. While various past studies explored how the brain predicts familiar occurrences, fewer have tried to uncover the mechanisms that prepare it for surprising events. One region known to play a role in experience-informed future predictions is the hippocampus, the brain's primary long-term memory center.
Researchers recently carried out a study aimed at better understanding how the brain prepares for unexpected visual experiences. Their paper, published in Nature Neuroscience, suggests that fast, large-amplitude, brief bursts of oscillatory activity in the hippocampus (i.e., hippocampal ripples) influence how the visual cortex, the part of the brain responsible for processing visual information, responds to surprising stimuli after they appear.

Researchers designed a new experiment that specifically probed activity in the hippocampus before predictable and unpredictable stimuli. This experiment involved 17 patients with epilepsy who had electrodes implanted in their brains as part of their treatment.
The results of this study suggest that the hippocampus does more than store memories of past events. In fact, it also appears to actively estimate how informative the future is likely to be, adjusting the sensitivity of other brain regions based on its predictions.

In computational terms, hippocampal ripples appear to encode predicted uncertainty, allowing the brain to assign greater weight to incoming information when it is expected to be particularly valuable.
Why does this matter? Efficient learning depends not only on how the brain responds to new information, but also on how well it prepares for it.

Darya Frank et al, Human hippocampal ripples tune cortical responses based on predicted uncertainty, Nature Neuroscience (2026). DOI: 10.1038/s41593-026-02345-6.

Comment by Dr. Krishna Kumari Challa on Saturday

No evidence mobile phones cause brain cancer—new study
Comprehensive analysis of 63 studies (1994–2022) shows no association between mobile phone use and brain, head, or neck cancers, regardless of duration or intensity of use. Additional reviews report no link between radio/TV transmission and childhood leukemia. Overall evidence for most other health outcomes is limited or low quality, but current exposure limits appear adequate and consistent with stable brain cancer incidence rates.

Comment by Dr. Krishna Kumari Challa on Saturday

What people look at most reflects their brains' specialization

While people explore the environment around them, their eyes constantly move between different objects, faces and other specific segments of a visual scene. This dynamic process allows them to prioritize visual information relevant to a task at hand or that they find more interesting, ignoring details or items in their surroundings that they deem less important.

Short pauses on a specific part of a visual scene are known as fixations. Past studies have shown that different people can exhibit distinct fixation patterns. For instance, some people might spend more time looking at faces, while others might pause longer on written words or specific types of objects.

Researchers recently carried out a study aimed at better understanding the relationship between what people tend to gaze at most and how their brains represent visual information. Their findings, published in Nature Human Behaviour, suggest that where people naturally direct their gaze reflects how their individual brains encode different types of visual stimuli.

Individuals reliably differ in how they look at complex visual scenes, with the most prominent variation in their propensity to fixate on faces and text.

To explore the link between people's fixation patterns and how their brains represent visual information, the researchers recruited 61 adults and asked them to complete a basic visual task. This task required them to observe complex natural scenes.

While the study participants looked at these scenes, the researchers tracked their gaze using eye-tracking technology. During a separate experiment, they also used an imaging technique called functional magnetic resonance imaging (fMRI) to collect scans of the participants' brains while they were shown images of faces, words or other visual stimuli.

They found that the propensity to fixate faces or text goes along with enhanced distinctiveness and enlarged functional regions of corresponding categorical representations in the ventral stream. These, in turn, predicted performance on reading and face-recognition tasks.

 found that participants exhibited different fixation patterns, with some spontaneously gazing more at faces and others at words. These distinct fixation patterns were associated with differences in the size and distinctiveness of specific brain regions.

Regions known to play a role in processing faces appeared to be larger and more distinctive in the brains of people who looked more frequently at faces. On the other hand, those who naturally tended to gaze more at text appeared to have larger functional regions specialized in processing written words.

Interestingly, the researchers also found that participants who looked more at faces performed significantly better on face-recognition tasks. In contrast, those who fixated more on text achieved better results on reading tasks.

Thus, active vision appears linked to the precision of category-selective encoding and corresponding neural resources in the individual brain," wrote the authors in their research paper.

Diana Kollenda et al, Active vision is linked to category selectivity in the individual brain, Nature Human Behaviour (2026). DOI: 10.1038/s41562-026-02494-5.

Comment by Dr. Krishna Kumari Challa on Saturday

New body index aims to move beyond BMI and works for babies too

Body Mass Index (BMI) has long been used in public health and clinical settings as a simple tool to classify an individual's physical status based on their height and weight. Originally developed in the 1830s by Belgian mathematician Adolphe Quetelet, BMI was designed to describe the characteristics of the average man rather than to assess an individual's health, and it did not account for age, sex, ethnicity or body composition.

For nearly two centuries, BMI has been the go-to measure for healthy body size, but its limitations have sparked a search for a better way to understand the human body. Enter the Consistent Body Mass Index (CBMI), a new approach that questions BMI's underlying assumption that body weight scales with height squared.

Instead, in this new study, researchers used physics and geometry to show that weight is more naturally connected to height cubed (CBMI=(m/h³)1/2), because a human body is a three-dimensional structure. By modeling the body as a cylinder, they developed a formula that links weight, height and waist circumference and better represents the body's proportions.

To see how the model held up in real people, researchers tested it on 400 participants, ranging from newborns to 75-year-olds. CBMI turned out to be a much better way to judge someone's physical health than standard BMI. The numbers backed it up, too: For the entire group, the correlation coefficient (r) was 0.837, a statistical measure of how closely two things move together. The relationship was strongest in children and weaker in adult men.

Serdar Beji et al, Development of a consistent body mass index, Scientific Reports (2026). DOI: 10.1038/s41598-026-61284-1

Comment by Dr. Krishna Kumari Challa on Friday

Roasted and browned: How gut bacteria break down heated foods

Crusty bread, fried meat and roasted coffee owe their characteristic taste and browning to chemical reactions that occur when foods are heated. In the so-called Maillard reaction, amino acids—the building blocks of proteins—react with sugars to produce modified forms of natural dietary compounds.

Heating foods generates modified amino acids such as Nε-carboxymethyllysine (CML) that reach the colon and interact with gut microbiota. In Escherichia coli, the enzyme SpeC degrades CML and other modified amino acids, indicating broad degradative capacity across the gut microbiome. This metabolism produces biogenic amines and is associated with diet-related diseases, suggesting mechanistic links between processed foods, microbial metabolism, and host health.

Researchers have now investigated how such dietary compounds are formed, obtaining new insights into the interplay of diet and gut microbiome.
Their focus was on a modified form of the natural amino acid lysine called Nε-carboxymethyllysine, or CML for short, which often occurs in heated foods. In contrast to natural amino acids, their modified forms are absorbed incompletely or not at all in the small intestine. As such, they pass to the large intestine, where they encounter the gut microbiota—the community of microorganisms that plays an important role in digestion, the immune system and health.

The research team demonstrated in the gut bacterium Escherichia coli that the enzyme SpeC is able to break down CML in addition to its previously known function. The bacteria do not need to develop entirely new tools for this task. Instead, they repurpose their existing repertoire in a creative way. It is particularly notable that SpeC does not recognize CML alone but, like a Swiss pocket knife, can also process other chemically modified amino acids.
Such side activities can give bacteria an initial route to access new dietary compounds. If such a compound becomes regularly available, adaptation can turn the Swiss pocket knife' SpeC into a more efficient tool specialized for this task.
Computational analyses suggest that such degradative capacities are widespread in the human gut microbiome. The study also identifies links to several diseases associated with diet and lifestyle, including bowel cancer, fatty liver disease and hepatitis. It is conceivable, for example, that the bacterial breakdown of CML creates advantages for certain bacteria in an inflamed gut environment. In addition, novel biogenic amines are produced during the breakdown of the chemically modified amino acids—a molecular group that is the subject of intense debate as mediators of bacteria-host communication.

These links do not yet prove a cause-and-effect relationship. But they do suggest that processed food, microbial metabolic pathways and health status may be more closely connected than previously assumed.

Erica F. Aveta et al, Deciphering underground decarboxylase activity towards Nε-modified lysine derivatives in enterobacteria, Food Chemistry (2026). DOI: 10.1016/j.foodchem.2026.150234

Comment by Dr. Krishna Kumari Challa on Friday

Sleep disorders don't just exhaust you, they change your brain

Sleep disorders may do more than leave people feeling tired. New research from Florida International University shows that sleep disorders are associated with structural changes in brain regions involved in attention, motivation and decision-making.

Sleep disorders are associated with structural brain alterations, including thalamic (pulvinar) reductions linked to impaired attention and cognitive control across dyssomnias and parasomnias. Parasomnias additionally show changes in the posterior cingulate cortex, related to motivation, decision-making, and emotion regulation, indicating partly shared and partly distinct neural substrates.

Researchers identified decreases in the thalamus, a brain region critical for filtering information, maintaining focus and supporting higher-level thinking. They specifically found structural changes in the pulvinar, part of the thalamus that helps direct attention and regulate cognitive control.
These changes were also linked to broader brain networks involved in focus and task performance, helping explain why disrupted sleep can contribute to slower responses, impaired decision-making and an increased risk of mistakes and accidents.
The study also uncovered patterns unique to parasomnias. Researchers found structural changes in the posterior cingulate cortex, a region involved in motivation, decision-making and emotional regulation. These findings may help explain why people with parasomnias sometimes experience changes in mood, behavior and emotional control.

Researchers did not find consistent structural changes unique to dyssomnias, suggesting different sleep disorders may affect the brain in distinct ways depending on how sleep is disrupted.

Katharine E. Crooks et al, Sleep disorders and structural alterations in brain regions linked with motivation: a neuroimaging meta-analysis, Scientific Reports (2026). DOI: 10.1038/s41598-026-40818-7

Comment by Dr. Krishna Kumari Challa on Friday

Facial movement analysis detects deepfake videos with more than 95% accuracy

A self-supervised deepfake detection method analyzes discrepancies between audio-predicted and observed facial movements using a 53-parameter FLAME expression model. Pre-trained on >450 hours of video and personalized with ~60 s of target footage, it attains >95% accuracy on standard benchmarks and Sora 2 videos, outperforming supervised, artifact-based detectors.

Kaede Shiohara et al, ExposeAnyone: Personalized Audio-to-Expression Diffusion Models Are Robust Zero-Shot Face Forgery Detectors, arXiv (2026). DOI: 10.48550/arxiv.2601.02359

Comment by Dr. Krishna Kumari Challa on Friday

India's monsoon rain depends on where air gets cleaner
Global aerosol reductions enhance Indian monsoon rainfall more than South Asian cuts alone, with all-India rain increasing 0.28 mm day⁻¹ versus 0.19 mm day⁻¹. Pollution reductions over East Asia can locally increase rain there but decrease it over parts of India via circulation changes, indicating that coordinated international air-quality policy is critical for managing monsoon-dependent water resources.

Ankit Bhandekar et al, South Asian monsoon response to regional aerosol emission reductions: insights from RAMIP, Environmental Research: Climate (2026). DOI: 10.1088/2752-5295/ae7fad

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