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Comment by Dr. Krishna Kumari Challa 23 hours ago

GoT-ChA: New tool reveals how gene mutations affect cells

A team co-led by researchers at Weill Cornell Medicine and the New York Genome Center has developed an advanced method for revealing how gene mutations disrupt the normal packaging of DNA. These structural changes, which alter patterns of gene activity in a cell, are known as epigenetic changes and can lead to malignancy.

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Why evolution often favors small animals and other organisms

Small really does seem to be beautiful in evolutionary terms. The largest dinosaurs, pterosaurs and mammals may look impressive but these giants are vastly outnumbered by microscopic bacteria and single-celled algae and fungi. Small organisms are also ancient and incredibly resilient.

Comment by Dr. Krishna Kumari Challa yesterday

Sky-high vanity: Constructing the world's tallest buildings creates high emissions, researchers say

Since ancient times, people have built structures that reach for the skies—from the steep spires of medieval towers to the grand domes of ancient cathedrals and mosques. Today the quest is to build the world's tallest skyscrapers, such as Burj Khalifa in Dubai. Soaring above the rest, its decorative spire accounts for 29% of its total height—4,000 tons of structural steel just for aesthetics.

Burj Khalifa isn't unique in this respect. "Vanity height"—the extra height from a skyscraper's highest occupied floor to its architectural top—shapes city skylines around the globe.
In a world where environmental concerns are paramount, is such architectural vanity justifiable?
Research shows the pursuit of "vanity height" makes this a pressing issue. Even a modest spire increases the carbon emissions from the production of materials for a skyscraper's structure by about 15%.

The hidden cost of vanity height
Sixty years ago, the renowned Bangladeshi-American architect and engineer Fazlur Rahman Khan demonstrated the exponential impact of a building's height on the amount of material needed to build it. Indeed, doubling the height of a building could triple the structural materials required. A stronger structure, using more materials, is needed to withstand greater wind and earthquake loads on taller buildings. This means there's a large "embodied carbon premium for height." This premium is the additional greenhouse gas emissions from producing the extra materials needed for a taller skyscraper. A telling example from our study shows that even a modest spire, making up 16% of a building's total height, can increase the embodied carbon of a 90-story skyscraper by 14%. In maximizing the building's height for aesthetic, status or financial reasons, designers are prioritizing these concerns over environmental sustainability.

In light of these findings, researchers call on the council on Tall Buildings and Urban Habitat to remove the incentive for vanity height. They propose the “height to highest occupied floor” be adopted as the main standard for ranking skyscrapers by height.

https://www.sciencedirect.com/science/article/pii/S0959652624017827...

https://theconversation.com/sky-high-vanity-constructing-the-worlds...

Comment by Dr. Krishna Kumari Challa yesterday

AI systems are already skilled at deceiving and manipulating humans, study shows

Many artificial intelligence (AI) systems have already learned how to deceive humans, even systems that have been trained to be helpful and honest. In a review article published in the journal Patterns on May 10, researchers describe the risks of deception by AI systems and call for governments to develop strong regulations to address this issue as soon as possible.

AI developers do not have a confident understanding of what causes undesirable AI behaviors like deception. But generally speaking, researchers think AI deception arises because a deception-based strategy turned out to be the best way to perform well at the given AI's training task. Deception helps them achieve their goals.

The most striking example of AI deception the researchers uncovered in their analysis was Meta's CICERO, an AI system designed to play the game Diplomacy, which is a world-conquest game that involves building alliances. Even though Meta claims it trained CICERO to be "largely honest and helpful" and to "never intentionally backstab" its human allies while playing the game, the data the company published along with its Science paper revealed that CICERO didn't play fair.

They  found that Meta's AI had learned to be a master of deception.

Other AI systems demonstrated the ability to bluff in a game of Texas hold 'em poker against professional human players, to fake attacks during the strategy game Starcraft II in order to defeat opponents, and to misrepresent their preferences in order to gain the upper hand in economic negotiations.

While it may seem harmless if AI systems cheat at games, it can lead to "breakthroughs in deceptive AI capabilities" that can spiral into more advanced forms of AI deception in the future.

Some AI systems have even learned to cheat tests designed to evaluate their safety, the researchers found. In one study, AI organisms in a digital simulator "played dead" in order to trick a test built to eliminate AI systems that rapidly replicate.

By systematically cheating the safety tests imposed on it by human developers and regulators, a deceptive AI can lead us humans into a false sense of security.

The major near-term risks of deceptive AI include making it easier for hostile actors to commit fraud and tamper with elections, warn experts. Eventually, if these systems can refine this unsettling skill set, humans could lose control of them.

As the deceptive capabilities of AI systems become more advanced, the dangers they pose to society will become increasingly serious.

AI deception: A survey of examples, risks, and potential solutions, Patterns (2024). DOI: 10.1016/j.patter.2024.100988

Comment by Dr. Krishna Kumari Challa yesterday

The research team noted that rumblings and gestures were often combined. Behaviors during greetings also sometimes involved urination, defecation and secreting sweat in the temporal gland, which emits odors into the air.

The researchers also found that the type of behaviors differed depending on whether the two elephants were looking at one another—most were more likely to engage in gestures when they knew the other elephant was looking at them. To get the attention of elephants who hadn't noticed them, they were also seen to engage in ear-flapping, which generates a lot of noise.

The research team concludes that the gestures and vocalizations used by the elephants appear to be part of a complicated system of communication used by the elephants to convey information during encounters.

Vesta Eleuteri et al, Multimodal communication and audience directedness in the greeting behaviour of semi-captive African savannah elephants, Communications Biology (2024). DOI: 10.1038/s42003-024-06133-5

Part 2

Comment by Dr. Krishna Kumari Challa yesterday

Elephants use gestures and vocal cues when greeting each other, study reports

A team of animal behaviourists has found that elephants use gestures and vocal cues when they greet one another.

In their study, published in the journal Communications Biology, the group observed a month's worth of greetings between African elephants living in the Jafuta Reserve in Zimbabwe in 2021.

Prior research has shown that elephants are highly intelligent, ranking close to dolphins. They also have complex matriarchal social structures. For this new study, the research team wondered if elephants have ways to communicate with one another that had not been observed during prior research efforts. They embarked on an observational study focused on elephant greetings.
The researchers ventured into the field at the reserve in Zimbabwe and watched and recorded encounters between elephants for one month in 2021. They observed 1,014 physical actions taken by elephants engaged in a greeting and 268 vocalizations.

The researchers found that elephants place importance on greeting one another. When two elephants who have not seen each other for a while meet, they both engage in apparently meaningful behavior. Gestures included swinging the trunk or using it to touch, ear-flapping and ear-spreading. Vocalizations tended to be rumbles of different sorts.

Part 1

Comment by Dr. Krishna Kumari Challa on Friday

How to illuminate the ‘ugly’ side of science
Data repositories, workshops and alternative journals allow scientists to share and discuss negative results, which could help to solve the reproducibility crisis and give machine learning a boost. Publishing negative-result studies is often seen as not worth the time and effort, yet “understanding the reasons for null results can really test and expand our theoretical understanding”, says psychologist Wendy Ross. And highlighting negative results can help students to see that “you are not a bad researcher because you fail”, adds computer scientist Ella Peltonen.

https://www.nature.com/articles/d41586-024-01389-7?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa on Friday

Scientists pinpoint new vaccine adjuvant that promotes potent anti-tumor immunity

Scientists  have made an important breakthrough that offers promise for developing new immune therapies for cancer. They have discovered that a vaccine adjuvant called C100 promotes potent anti-tumor immunity when it is injected directly into tumors in an animal model.

The scientists found that C100, derived from chitin—one of the most common building materials in nature, and which gives strength to the exoskeletons of crustaceans, insects, and the cell walls of fungi—is highly effective at stimulating a key sensing and signaling molecule which regulates anti-tumor immune responses.

Their work has been published in Cell Reports Medicine.

The scientists now know how C100 exclusively activates one arm of a specific signaling pathway (cGAS-STING) without causing inflammatory responses that could interfere with anti-tumor immunity and which may otherwise prevent therapies from achieving clinical success.

Additionally, the research team discovered that injecting C100 led to synergistic therapeutic effects with a "checkpoint blocker," which can release the brakes on the immune response.

 Intratumoural delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR and CD8+ T cell dependant anti-tumour immunity, Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101560. www.cell.com/cell-reports-medi … 2666-3791(24)00252-0

Comment by Dr. Krishna Kumari Challa on Friday

Researchers estimate vaccines have saved 154 million lives over past half-century

An international team of health and medical researchers including workers at the WHO, working with economists and modeling specialists, has found that the use of vaccines to prevent or treat disease has saved the lives of approximately 154 million people over the past half-century.

In their study, published in The Lancet, the group used mathematical and statistical modeling to develop estimates for lives saved due to vaccines and then added them together to find the total. The goal of the team was to evaluate the degree of success of the Expanded Program on Immunization (EPI) launched by the World Health Organization in 1974. The goal of the EPI has been to vaccinate all the children in the world against the most common deadly diseases. At its onset, the list included seven diseases; it has since been expanded to include 14. As part of that effort, research has been conducted to develop vaccines, test them and then to use them once they have been declared both safe and effective. Since its inception, the EPI program has led to the development of many vaccines and the vaccination of millions of people, preventing suffering and death. In this new effort, the research team sought to find out how successful the program has been. The work involved collecting and analyzing data at the local, regional and global levels. As part of that effort, they created 22 models based on 50 years of vaccination data for people around the world. The team then used the models to estimate lives saved and found the total to be approximately 154 million since 1974. The research team also found that children benefited the most from vaccination—101 million of the lives saved were under the age of 1. They also found evidence that vaccination programs had a major impact on infant mortality rates—over the past half-century, rates have declined globally by 40%. The researchers also found that the measles vaccine made the biggest impact—it was responsible for 60% of the lives saved.

 Andrew J Shattock et al, Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization, The Lancet (2024). DOI: 10.1016/S0140-6736(24)00850-X

Comment by Dr. Krishna Kumari Challa on Friday

Study shows that astrocytes integrate information about past events in their soma

Neurons are known to communicate and integrate information they receive from their dendrites, branch-like structures extending from their body. In contrast, the activity in astrocytes, a class of star-shaped glial cells found in the central nervous system (CNS), has so far been assumed to be largely uncoordinated, thus lacking the central integration of information.

Researchers at University of Zurich and ETH Zurich recently gathered evidence suggesting that this widespread description of astrocytes might be false or at least incomplete, as they do in fact integrate information about past events.

Their findings, published in Nature Neuroscience, specifically reveal the conditional integration of calcium signals in processes taking place in the astrocytes' soma (i.e., cell body).

Peter Rupprecht et al, Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01612-8

Comment by Dr. Krishna Kumari Challa on Thursday

Computer models suggest modern plate tectonics are due to blobs left behind by cosmic collision

A small team of geologists and seismologists  has found evidence via computer modeling that suggest giant blobs of material near the Earth's core, believed to have been created by a cosmic collision 4.5 billion years ago, may be responsible for modern plate tectonics.

In their study, published in the journal Geophysical Research Letters, the group used existing data on the blobs, known more technically as large, low-velocity provinces (LLVPs), and used it to create computer simulations and models showing their impact on the Earth over long time scales.

In the 1980s, geophysicists discovered what they described as giant blobs of unknown material near Earth's center—one below the Pacific Ocean, the other below parts of Africa. Then, last year,  another team found evidence that the blobs (LLVPs) are remnants of Theia, a planet that struck the Earth 4.5 billion years ago. The rest of the debris from the collision, theory suggests, coalesced in Earth's orbit, forming the moon.

For this new study, the team  used computer models to show what sort of impact the LLVPs may have had on the Earth's crust over the past millions of years, and report evidence that they may be responsible for modern plate tectonics.

Data for the models came from seismic readings that have shown the LLVPs are made up of different material than either the core or mantle. After some tweaking, the models showed that approximately 200 million years after Theia struck the Earth, pressure from the LLVPs led to the creation of hot plumes stretching from near the core to the surface. That caused some sections of the surface to sink, which led to subduction.

Subduction eventually led to the breaks in the surface that today serve as borders for tectonic plates. The researchers suggest their models may explain why some of the oldest minerals on Earth show evidence of subduction.

Qian Yuan et al, A Giant Impact Origin for the First Subduction on Earth, Geophysical Research Letters (2024). DOI: 10.1029/2023GL106723

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