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Comment by Dr. Krishna Kumari Challa on March 5, 2014 at 9:44am

Immune cells undergo ‘spontaneous’ changes on a daily basis that could lead to cancers if they were not destroyed by our immune system, scientists have found.
http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3442.html
The research team in Australia found that the immune system was responsible for eliminating potentially cancerous immune B cells in their early stages, before they developed into B-cell lymphomas (also known as non-Hodgkin’s lymphomas).

This immune surveillance accounts for the surprising rarity of B-cell lymphomas in the population, given how often these spontaneous changes occur. The discovery could lead to the development of an early-warning test that identifies patients at high risk of developing B-cell lymphomas, enabling proactive treatment to prevent tumors from growing.

Dr Axel Kallies, the senior author of the study, said the discovery provided an answer to why B-cell lymphomas occur in the population less frequently than expected. “Each and every one of us has spontaneous mutations in our immune B cells that occur as a result of their normal function,” Dr Kallies said.

“It is then somewhat of a paradox that B cell lymphoma is not more common in the population.”

“Our finding that immune surveillance by T cells enables early detection and elimination of these cancerous and pre-cancerous cells provides an answer to this puzzle, and proves that immune surveillance is essential to preventing the development of this blood cancer.”

The research team made the discovery while investigating how B cells change when lymphoma develops.

“As part of the research, we ‘disabled’ the T cells to suppress the immune system and, to our surprise, found that lymphoma developed in a matter of weeks, where it would normally take years,” Dr Kallies said.

“It seems that our immune system is better equipped than we imagined to identify and eliminate cancerous B cells, a process that is driven by the immune T cells in our body.”

According to the scientists, the research would enable scientists to identify pre-cancerous cells in the initial stages of their development, allowing early intervention for patients at risk of developing B-cell lymphoma.

Comment by Dr. Krishna Kumari Challa on March 5, 2014 at 7:33am

Jurassic park all over again?

Giant Virus Resurrected from 30,000-Year-Old Ice

The discovery of the largest virus yet, still infectious, hints at the viral diversity trapped in permafrost

scientists have revived a giant virus that was buried in Siberian ice for 30,000 years — and it is still infectious. Its targets, fortunately, are amoebae, but the researchers suggest that as Earth's ice melts, this could trigger the return of other ancient viruses, with potential risks for human health.

The newly thawed virus is the biggest one ever found. At 1.5 micrometers long, it is comparable in size to a small bacterium. Evolutionary biologists Jean-Michel Claverie and Chantal Abergel, the husband-and-wife team at Aix-Marseille University in France who led the work, named it Pithovirus sibericum, inspired by the Greek word 'pithos' for the large container used by the ancient Greeks to store wine and food. “We’re French, so we had to put wine in the story,” says Claverie. The results are published in Proceedings of the National Academy of Sciences.

Abstract: The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine–thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they entirely replicate within cytoplasmic virion factories. In contrast, the recently discovered Pandoraviruses exhibit larger amphora-shaped virions 1 μm in length and guanine–cytosine-rich genomes up to 2.8 Mb long encoding up to 2,500 proteins. Their replication involves the host nucleus. Whereas the Megaviridae share some general features with the previously described icosahedral large DNA viruses, the Pandoraviruses appear unrelated to them. Here we report the discovery of a third type of giant virus combining an even larger pandoravirus-like particle 1.5 μm in length with a surprisingly smaller 600 kb AT-rich genome, a gene content more similar to Iridoviruses and Marseillevirus, and a fully cytoplasmic replication reminiscent of the Megaviridae. This suggests that pandoravirus-like particles may be associated with a variety of virus families more diverse than previously envisioned. This giant virus, named Pithovirus sibericum, was isolated from a >30,000-y-old radiocarbon-dated sample when we initiated a survey of the virome of Siberian permafrost. The revival of such an ancestral amoeba-infecting virus used as a safe indicator of the possible presence of pathogenic DNA viruses, suggests that the thawing of permafrost either from global warming or industrial exploitation of circumpolar regions might not be exempt from future threats to human or animal health.

http://www.pnas.org/content/early/2014/02/26/1320670111

Comment by Dr. Krishna Kumari Challa on March 4, 2014 at 9:10am

India is home to the largest number of bird species in the world. Preliminary findings of a recent global event — Great Backyard Bird Count — have put India on top of the list of 127 countries which sent their entries through pictures and videos.
In its report, 'Want to see a wide variety of birds? Head to India', the daily said, "India's emergence as a bird-watching hot spot underscores the rising worldwide popularity of the pastime." It put India on top with 765 species. The US came second with 637 species (till February 22).

The GBBC is jointly organized by the Cornell Lab of Ornithology, the National Audubon Society and the Bird Studies Canada. Though the US and Canada have been participating in the event since 1998, the first ever such 'global' bird count was organized in 2013 when participants from 110 countries sent their entries during February 15-18 last year.

Bird watchers from all seven continents had last year reported and documented 4,258 species from about 180 bird families. Mexico had topped the 2013 GBBC list with 645 species followed by the US (638), India (544), Costa Rica (508), Colombia (424), Australia (383), Panama (371) and Peru (325).

The second version of the global bird count, updated till February 28, however, showed that participants from 127 counties this time found 4,296 species with India reporting the highest number of 819 species followed by Mexico (683), USA (644), Costa Rica (609), Australia (501), Colombia (397), Panama (278) and Peru (138).

The event was launched in 1998 as the first online citizen-science project to collect data on wild birds and to display results in near real-time. Participants during the event period send snapshots of birds as their entries which are subsequently analyzed and documented by the organizers before displaying final results of the GBBC.

The participants will unite once again next year during February 13-16 to see how many of the world's 10,240 bird species can be found.

Final results of the four-day Great Backyard Bird Count (GBBC), held between February 14 and 17, are yet to be announced but the data analyzed and updated till February 28 shows that the final order may not change India's position.

A US newspaper, The Kansas City Star, flagged the preliminary findings of the global bird count first on February 22.

Comment by Dr. Krishna Kumari Challa on March 4, 2014 at 8:50am

Bio-batteries that run on sugar to power smartphones for 10 days
Scientists have developed a new battery that consumes sugar to generate electricity enough to power a smartphone for 10 days at a time.

The bio-battery designed by researchers at Virginia Polytechnic Institute and State University has a greater output per weight than the typical lithium-ion batteries used in most electronics.

The prototype version has the potential to be lighter and more powerful than the batteries typically found in today's portable electronic devices, including smartphones.

In the body, sugar is converted into energy in a process called metabolism, which decomposes sugar into carbon dioxide and water while releasing electrons.

Bio-batteries produce energy though the same conversion process by capturing the electrons that are generated in the decomposition of sugar with the same tools that the body uses.

As bio-batteries use materials that are biologically based, they are renewable and non-toxic, making them an attractive alternative to traditional batteries that need metals and chemicals to operate.

"By using the lithium-ion battery, for example, your phone can only last for one day, but in the future it will use sugar as the fuel then the phone could last 10 days," said Zhiguang Zhu, a researcher at Virginia Tech.

The new bio-battery gets its efficiency by using a novel system of enzymes, which are proteins that help the reaction to take place, Inside Science News Service (ISNS) reported.

The system uses two active enzymes that liberate two pairs of electrons from the sugar, while 10 other enzymes help to reset the reaction inside the bio-battery.

Once the reaction is reset, the active enzymes release another quartet of electrons.

After six cycles, the bio-battery extracts all of the energy bound in the sugar molecule, along with carbon dioxide and water.

The research was published in the journal Nature Communications.

Comment by Dr. Krishna Kumari Challa on March 4, 2014 at 8:33am

Imaging dynamics of small biomolecules inside live cells
http://esciencenews.com/articles/2014/03/03/imaging.dynamics.small....

Comment by Dr. Krishna Kumari Challa on March 4, 2014 at 8:30am

Scientists use laser-powered mind control to make flies flirt
Neurons treated with a heat-activated protein were activated with infrared lasers to trigger courtship behaviour
Neuroscientists have successfully controlled a fly’s behaviour with thermogenetics – a new technique that uses lasers to remotely activate brain neurons.
Using the ­whimsically named Fly Mind-Altering Device (also known as FlyMAD), researchers were able to trigger complex courtship behaviour in a target fly, essentially causing the insect to ‘fall in love’ with a ball of wax.

The research, led by Barry Dickson of the Howard Hughes Medical Institute in Ashburn, Virginia, is similar to optogenetics; a method that activates neurons using light and that has previously been used to control behaviour in mice.

However, while optogenetics require fibre-optic cables to be embedded into mice skulls to activate the genetically-altered neurons, thermogenetics achieves the same effect by using infrared lasers to deliver the ‘instructions’ directly to the fly’s brain.
Scientists have previously influenced fly behaviour by adding a heat-activated protein called TRPA1 to neurons associated with certain actions. When flies modified in this way are placed in a hot box the targeted neurons activate and trigger certain behaviours.

FlyMAD, however, uses a video camera to track the fly as it moves around a box before directing an infrared laser at the insect and activating the parts of its neural circuit that control courtship.
http://www.nature.com/news/laser-beam-makes-flies-flirt-1.14794

Comment by Dr. Krishna Kumari Challa on March 4, 2014 at 8:23am

Break-up of the supercontinent Gondwana about 130 Million years ago could have lead to a completely different shape of the African and South American continent with an ocean south of today’s Sahara desert, as geoscientists from the University of Sydney and the GFZ German Research Centre for Geosciences have shown through the use of sophisticated plate tectonic and three-dimensional numerical modelling. The study highlights the importance of rift orientation relative to extension direction as key factor deciding whether an ocean basin opens or an aborted rift basin forms in the continental interior.
What Sculpted Africa’s Margin?
http://www.redorbit.com/news/science/1113085773/what-sculpted-afric...

Comment by Dr. Krishna Kumari Challa on March 2, 2014 at 9:31am

'Don't Know Much About Science'
One in four Americans believes that the Sun revolves around the Earth.
What is noticeable is that other countries are trending upward in the acquisition of scientific knowledge, but the United States has remained more or less at a standstill. And in response to scientific questions that contradict established doctrine, Americans performed markedly worse, unless a qualifying preface such as "according to scientists" was appended to the questions
the study suggests that Americans value science as a career and the scientific community very highly. We don't know what scientists do -- 65 percent claimed they didn't know. In short, though we don't possess a lot of scientific knowledge, and though few of us know what scientists do, we think very highly of them and want our children to become scientists.
The NSF study confirms that the media's coverage and portrayal of science does not mirror the value we place on it. Less than 2 percent of traditional news coverage is related to science and technology, with coverage of Steve Jobs' passing, the end of the Space Shuttle program, Facebook's IPO and the Mars Curiosity rover taking the lion's share.

http://www.huffingtonpost.com/melanie-fine/dont-know-much-about-sci...

Comment by Dr. Krishna Kumari Challa on March 2, 2014 at 9:23am

Chronic insomnia results from a difference in brain function according to research reported by Dr. Rachel E. Salas, an assistant professor of neurology at the Johns Hopkins University School of Medicine, and colleagues in the Feb. 28, 2014, edition of the journal Sleep.

The researchers demonstrated that chronic insomniacs have more plasticity in the motor cortex of the brain. This finding not only explains the reason insomniacs cannot sleep but also explains the high level of muscular movement involved in sleep when insomniacs do sleep.
http://www.examiner.com/article/johns-hopkins-researchers-find-brai...

Comment by Dr. Krishna Kumari Challa on March 1, 2014 at 7:04am

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