Science, Art, Litt, Science based Art & Science Communication
JAI VIGNAN
All about Science - to remove misconceptions and encourage scientific temper
Communicating science to the common people
'To make them see the world differently through the beautiful lense of science'
Members: 22
Latest Activity: 6 hours ago
WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING
THIS IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS
“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”
"Being a scientist is a state of mind, not a profession!"
"Science, when it's done right, can yield amazing things".
The Reach of Scientific Research From Labs to Laymen
The aim of science is not only to open a door to infinite knowledge and wisdom but to set a limit to infinite error.
"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.
Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.
If you are scientifically literate the world looks very different to you.
We do science and science communication not because they are easy but because they are difficult!
“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"
Links to some important articles :
1. Interactive science series...
a. how-to-do-research-and-write-research-papers-part 13
b. Some Qs people asked me on science and my replies to them...
Part 6, part-10, part-11, part-12, part 14 , part- 8,
part- 1, part-2, part-4, part-5, part-16, part-17, part-18 , part-19 , part-20
part-21 , part-22, part-23, part-24, part-25, part-26, part-27 , part-28
part-29, part-30, part-31, part-32, part-33, part-34, part-35, part-36, part-37,
part-38, part-40, part-41, part-42, part-43, part-44, part-45, part-46, part-47
Part 48, part49, Critical thinking -part 50 , part -51, part-52, part-53
part-54, part-55, part-57, part-58, part-59, part-60, part-61, part-62, part-63
part 64, part-65, part-66, part-67, part-68, part 69, part-70 part-71, part-73 ...
.......306
BP variations during pregnancy part-72
who is responsible for the gender of their children - a man or a woman -part-56
c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7
d. science-s-rules-are-unyielding-they-will-not-be-bent-for-anybody-part-3-
e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9
f. why astrology is pseudo-science part 15
g. How Science is demolishing patriarchal ideas - part-39
2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes
3. Science communication series:
a. science-communication - part 1
b. how-scienitsts-should-communicate-with-laymen - part 2
c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3
d. the-importance-of-science-communication-through-art- part 4
e. why-science-communication-is-geting worse - part 5
f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6
g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7
h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8
i. science-writers-and-communicators-where-are-you - part 9
j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10
k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11
l. golden-rules-of-science-communication- Part 12
m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13
n. an-informed-patient-is-the-most-cooperative-one -part 14
o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15
p. the-most-difficult-part-of-science-communication - part 16
q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17
r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18
s. is-post-truth-another-name-for-science-communication-failure?
t. why-is-it-difficult-for-scientists-to-have-high-eqs
u. art-and-literature-as-effective-aids-in-science-communication-and teaching
v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them
** qs-people-asked-me-on-science-and-my-replies-to-them-part-173
w. why-motivated-perception-influences-your-understanding-of-science
x. science-communication-in-uncertain-times
y. sci-com: why-keep-a-dog-and-bark-yourself
z. How to deal with sci com dilemmas?
A+. sci-com-what-makes-a-story-news-worthy-in-science
B+. is-a-perfect-language-important-in-writing-science-stories
C+. sci-com-how-much-entertainment-is-too-much-while-communicating-sc
D+. sci-com-why-can-t-everybody-understand-science-in-the-same-way
E+. how-to-successfully-negotiate-the-science-communication-maze
4. Health related topics:
a. why-antibiotic-resistance-is-increasing-and-how-scientists-are-tr
b. what-might-happen-when-you-take-lots-of-medicines
c. know-your-cesarean-facts-ladies
d. right-facts-about-menstruation
e. answer-to-the-question-why-on-big-c
f. how-scientists-are-identifying-new-preventive-measures-and-cures-
g. what-if-little-creatures-high-jack-your-brain-and-try-to-control-
h. who-knows-better?
k. can-rust-from-old-drinking-water-pipes-cause-health-problems
l. pvc-and-cpvc-pipes-should-not-be-used-for-drinking-water-supply
m. melioidosis
o. desensitization-and-transplant-success-story
p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!
q. swine-flu-the-difficlulties-we-still-face-while-tackling-the-outb
r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine
s. don-t-ignore-these-head-injuries
u. allergic- agony-caused-by-caterpillars-and-moths
General science:
a.why-do-water-bodies-suddenly-change-colour
b. don-t-knock-down-your-own-life-line
c. the-most-menacing-animal-in-the-world
d. how-exo-planets-are-detected
e. the-importance-of-earth-s-magnetic-field
f. saving-tigers-from-extinction-is-still-a-travail
g. the-importance-of-snakes-in-our-eco-systems
h. understanding-reverse-osmosis
i. the-importance-of-microbiomes
j. crispr-cas9-gene-editing-technique-a-boon-to-fixing-defective-gen
k. biomimicry-a-solution-to-some-of-our-problems
5. the-dilemmas-scientists-face
6. why-we-get-contradictory-reports-in-science
7. be-alert-pseudo-science-and-anti-science-are-on-prowl
8. science-will-answer-your-questions-and-solve-your-problems
9. how-science-debunks-baseless-beliefs
10. climate-science-and-its-relevance
11. the-road-to-a-healthy-life
12. relative-truth-about-gm-crops-and-foods
13. intuition-based-work-is-bad-science
14. how-science-explains-near-death-experiences
15. just-studies-are-different-from-thorough-scientific-research
16. lab-scientists-versus-internet-scientists
17. can-you-challenge-science?
18. the-myth-of-ritual-working
19.science-and-superstitions-how-rational-thinking-can-make-you-work-better
20. comets-are-not-harmful-or-bad-omens-so-enjoy-the-clestial-shows
21. explanation-of-mysterious-lights-during-earthquakes
22. science-can-tell-what-constitutes-the-beauty-of-a-rose
23. what-lessons-can-science-learn-from-tragedies-like-these
24. the-specific-traits-of-a-scientific-mind
25. science-and-the-paranormal
26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?
27. how-the-brain-of-a-polymath-copes-with-all-the-things-it-does
28. how-to-make-scientific-research-in-india-a-success-story
29. getting-rid-of-plastic-the-natural-way
30. why-some-interesting-things-happen-in-nature
31. real-life-stories-that-proves-how-science-helps-you
32. Science and trust series:
a. how-to-trust-science-stories-a-guide-for-common-man
b. trust-in-science-what-makes-people-waver
c. standing-up-for-science-showing-reasons-why-science-should-be-trusted
You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum
( Please go through the comments section below to find scientific research reports posted on a daily basis and watch videos based on science)
Get interactive...
Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.
Our mail ID: kkartlabin@gmail.com
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Sunday. 1 Reply 0 Likes
Q: How Big is the universe?Krishna: The total size of the universe is not known, and some scientists think it could be many times larger than the observable portion. For example, one hypothesis…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Saturday. 1 Reply 0 Likes
Q: Why do some people commit crimes? What does science say about it?Krishna: It is easy to blame people. But did you know that the way your brain wires or rewires because of different situations it…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa Jun 25. 1 Reply 0 Likes
Cars may be a modern phenomenon, but motion sickness is not. More than 2,000 years ago, the physician …Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa Jun 25. 1 Reply 0 Likes
"De-evolution" or "devolution" is a concept suggesting that species can revert to more primitive forms over time.Some scientists don't accept this concept at all. They say Evolution is a continuous…Continue
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There are hundreds of these retrotransposon sequences in our genome. Why not permanently inactivate them, like some species have done? They must have some adaptive value for us, the scientists thought.
They used reverse transcriptase inhibiting drugs, commonly used to suppress HIV replication in patients, to inhibit the replication of retrotransposons in mice. These drugs did not alter blood cell production in normal mice but blocked the increase in blood-forming stem cells and red blood cell production during pregnancy, leading to anemia.
As researchers further explored mechanisms activating blood cell production, they found retrotransposons were being detected by the immune sensors, cGAS and STING. These sensors induce interferon production after viral infection or replication of retrotransposons.
They found the retrotransposons turned on just enough interferon to activate blood cell production.
What these scientists discovered in mice is also true in humans, they found.
Earlier they also found that estrogen contributes to blood-forming stem cell activation during pregnancy.
Julia Phan et al, Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis, Science (2024). DOI: 10.1126/science.ado6836
Part2
Ancient viral remnants in the human genome are activated during pregnancy and after significant bleeding in order to increase blood cell production, an important step toward defining the purpose of "junk DNA" in humans, according to research published in Science.
These scientists set out to discover how hematopoietic, or blood-forming, stem cells—which typically divide infrequently—are activated during pregnancy and after blood loss.
When they compared activated genes in stem cells from pregnant versus nonpregnant mice, they found retrotransposons had switched on in stem cells from pregnant mice.Mushrooms exist in a breathtaking variety of shapes, colors and sizes. Especially in autumn, mushroom hunters go into the forests to find the tastiest of them, prepare them in multiple ways and eat them with relish. However, it is well known that there are also poisonous mushrooms among them and it is life-saving to distinguish between them. But are these mushrooms really poisonous?
Researchers have investigated this question and recently published the results of a study about muscarine in Angewandte Chemie International Edition.
This toxin is found in various mushrooms, the best known of which is the fly agaric mushroom (Amanita muscaria), which also gave the toxin its name. However, considerably higher concentrations of muscarine are found in fiber cap mushrooms and fool's funnel mushrooms.
Researchers have now been able to show that muscarine is not only present in mushrooms as such, but it can also be stored as a harmless precursor and only be released when mushrooms got injured.
Muscarine was discovered 150 years ago as the first fungal toxin. The current study was able to prove that it is stored, for example, in the fool's funnel mushroom Clitocybe rivulosa as 4phosphomuscarin, which is less toxic.
There are indications that other substances are also present because pure muscarine apparently has a different effect than a mushroom containing muscarine.
The fool's funnel mushroom is also known as the false champignon and can easily be confused with the real champignon. Only when the mushroom is damaged by cutting, cooking or digestion, an enzyme releases the poisonous muscarine from this precursor molecule.
In other mushrooms however, muscarine is already present in its active form. It is not uncommon for organisms to show defense and protective reactions when they are damaged, for example by being eaten by animals.
The mixture of free active and "hidden" inactive muscarine, which only becomes active poison when eaten, increases the danger of certain types of mushrooms such as the funnel mushrooms. These results could help doctors and toxicologists to better assess the actual danger of certain types of fungi and treat poisoning more efficiently.
Muscarine interferes with the transmission of signals by the neurotransmitter acetylcholine and leads to permanent excitation. The consequences are increased salivation and lacrimation, sweating, vomiting, diarrhea, circulatory collapse and even fatal cardiac paralysis.
It is irrelevant whether the poison has already been ingested in free form or as a precursor that is only activated in the body. The correct identification of edible mushrooms is therefore still an important prerequisite for an enjoyable and carefree mushroom meal.
Sebastian Dörner et al, The Fatal Mushroom Neurotoxin Muscarine is Released from a Harmless Phosphorylated Precursor upon Cellular Injury, Angewandte Chemie International Edition (2024). DOI: 10.1002/anie.202417220
In recent years, medical researchers have devised various new techniques that can help them to organize and analyze large amounts of research data, uncovering links between different variables (e.g., diseases, drugs, proteins, etc.). One of these methods entails building so-called biomedical knowledge graphs (KGs), which are structured representations of biomedical datasets.
Researchers recently showed that large language models (LLMs), machine learning techniques which are now widely used to generate and alter written texts, could be used by malicious users to poison biomedical KGs. Their paper, published in Nature Machine Intelligence, shows that LLMs could be used to generate fabricated scientific papers that could in turn produce unreliable KGs and adversely impact medical research.
Junwei Yang et al, Poisoning medical knowledge using large language models, Nature Machine Intelligence (2024). DOI: 10.1038/s42256-024-00899-3.
**
A new study conducted on roundworms finds that a common plastic ingredient causes breaks in DNA strands, resulting in egg cells with the wrong number of chromosomes.
Benzyl butyl phthalate (BBP) is a chemical that makes plastic more flexible and durable, and is found in many consumer products, including food packaging, personal care products and children's toys. Previous studies have shown that BBP interferes with the body's hormones and affects human reproduction and development. In the new study, researchers tested a range of doses of BBP on the nematode Caenorhabditis elegans and looked for abnormal changes in egg cells. They saw that at levels similar to those detected in humans, BBP interferes with how newly copied chromosomes are distributed into the sex cells. Specifically, BBP causes oxidative stress and breaks in the DNA strands, which lead to cell death and egg cells with the wrong number of chromosomes.
Based on these findings, the researchers propose that BBP exposure alters gene expression in ways that cause significant damage to the DNA, ultimately leading to lower quality egg cells with abnormal chromosomes. The study also showed that C. elegans metabolizes BBP in the same way as mammals, and is impacted at similar BBP levels that occur in humans, suggesting that C. elegans is an effective model for studying the impacts on people. Overall, the study underscores the toxic nature of this very common plastic ingredient and the damage it causes to animal reproduction.
Henderson AL, Karthikraj R, Berdan EL, Sui SH, Kannan K, Colaiácovo MP (2024) Exposure to benzyl butyl phthalate (BBP) leads to increased double-strand break formation and germline dysfunction in Caenorhabditis elegans, PLoS Genetics (2024). DOI: 10.1371/journal.pgen.1011434
Pipelines, sprinklers, and other infrastructure in oxygen-free environments are vulnerable to microbially induced corrosion (MIC)—a process where microorganisms degrade iron-based structures, potentially leading to costly damages or even collapses.
Unlike rust, which is caused by a chemical reaction with oxygen, MIC occurs in oxygen-free environments. The microbes responsible thrive on the iron itself, producing a destructive reaction that damages the material. This kind of corrosion costs industries billions of dollars annually, particularly in sectors such as oil and gas. Identifying and preventing the microbial activity behind the corrosion is therefore of importance.
Now microbiologists have uncovered new details about how one microbial strain of the species Methanococcus maripaludis corrodes iron in an extremely efficient way. The study is published in npj Biofilms and Microbiomes.
The study refutes the long-standing belief that these microbes release enzymes into the environment to corrode iron and have them produce nutrients for the microbe's growth. Instead, the researchers show that the microbes cling directly to the iron surface, using sticky enzymes on their cell walls to extract what they need without wasting energy on releasing enzymes that may not reach the iron surface.
Once attached to the iron surface, the microbe initiates corrosion, quickly developing a black film on the material's surface.
The microbes will quickly create pits under this black film, and within a few months, significant damage will occur.
According to the researchers, microbial adaptation like this is an example of how microbes can learn to thrive in human-made environments. In this case, Methanococcus maripaludis, has learned to survive on and efficiently get energy from iron structures.
Such microbial adaptation poses not only a financial burden but also an environmental one. These microbes are methanogenic, meaning they produce methane. Methane is a potent greenhouse gas, so it does cause some concern that microbes adapting to human-made, built environments produce methane more effectively. These new adaptations may spur increases in methane emissions.
Satoshi Kawaichi et al, Adaptation of a methanogen to Fe0 corrosion via direct contact, npj Biofilms and Microbiomes (2024). DOI: 10.1038/s41522-024-00574-w
Methane-producing microbes also thrive on a variety of mineral particles that are being released to the natural environment by climate change and other anthropogenic activities. Such particles come from industry, agriculture, forest fires, river runoffs, melting glaciers, etc., and they may promote the activity of certain methane-producing microbes.
If someone wants to add 3D-printed elements to a room—a footrest beneath a desk, for instance—the project gets more difficult. A space must be measured. The objects must then get scaled, printed elsewhere and fixed in the right spot. Handheld 3D printers exist, but they lack accuracy and come with a learning curve.
Researchers now created Mobiprint, a mobile 3D printer that can automatically measure a room and print objects onto its floor. The team's graphic interface lets users design objects for a space that the robot has mapped out. The prototype, which the team built on a modified consumer vacuum robot, can add accessibility features, home customizations or artistic flourishes to a space.
The team presented its work Tuesday, Oct. 15, at the ACM Symposium on User Interface Software and Technology
https://programs.sigchi.org/uist/2024/program/content/170934
A new study shows that a biomedical tool can successfully deliver genetic material to edit faulty genes in developing fetal brain cells. The technology, tested in mice, might have the potential to stop the progression of genetic-based neurodevelopmental conditions, such as Angelman syndrome and Rett syndrome, before birth.
The implications of this tool for treating neurodevelopmental conditions are profound. We can now potentially correct genetic anomalies at a foundational level during critical periods of brain development, say the researchers associated with the study.
The research team hopes to develop this technology into treatments for genetic conditions that can be diagnosed during prenatal testing. The treatments can be given in the womb to avoid more damage as cells develop and mature.
Proteins have a crucial role in the way our bodies function. They are assembled in cells based on instructions from messenger RNA (mRNA). In certain genetic conditions, the genes express (produce) more or fewer proteins than the body needs. In such cases, the body might get dysregulated and need to silence an overactive gene or supplement the low protein levels.
Proteins have large and complex structures, which makes them hard to deliver. Their delivery remains a huge challenge and a dream for treating diseases.
Instead of delivering proteins, scientists found a way to deliver mRNA to cells that will be translated to functional proteins within the cells. This delivery method uses a unique lipid nanoparticle (LNP) formulation to carry mRNA. The objective is to introduce (transfect) mRNA genetic material into the cells. The mRNA would then translate instructions to build proteins.
Delivery of mRNA using LNP is already transforming disease treatments. It has applications in vaccine development, gene editing and protein replacement therapy. Recently, mRNA delivery has become more popular with its use in Pfizer and Moderna COVID-19 vaccines.
Kewa Gao et al, Widespread Gene Editing in the Brain via In Utero Delivery of mRNA Using Acid-Degradable Lipid Nanoparticles, ACS Nano (2024). DOI: 10.1021/acsnano.4c05169 Sheng Zhao et al, Acid-degradable lipid nanoparticles enhance the delivery of mRNA, Nature Nanotechnology (2024). DOI: 10.1038/s41565-024-01765-4
The team validated their database's predictions in the lab, where they made almost 3,000 mutations on over 1,000 proteins and tested their impact on almost 7,000 protein-protein interaction pairs. Preliminary research based on these findings is already underway to develop and test treatments for lung and endometrial cancers. The team also demonstrated that their model's protein-protein interaction mutations can predict:
Survival rates and prognoses for various cancer types, including sarcoma, a rare but potentially deadly cancer.
Anti-cancer drug responses in large pharmacogenomics databases.
The researchers also experimentally validated that protein-protein interaction mutations between the proteins NRF2 and KEAP1 can predict tumor growth in lung cancer, offering a novel target for targeted cancer therapeutic development.
A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations, Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02428-4
Part 2
Scientists have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication.
The computational tool is called PIONEER (Protein-protein InteractiOn iNtErfacE pRediction). Researchers demonstrated PIONEER's utility by identifying potential drug targets for dozens of cancers and other complex diseases in a recently published Nature Biotechnology article.
Genomic research is key in drug discovery, but it is not always enough on its own. When it comes to making medications based on genomic data, the average time between discovering a disease-causing gene and entering clinical trials is 10–15 years.
In theory, making new medicines based on genetic data is straightforward: mutated genes make mutated proteins. Scientists try to create molecules that stop these proteins from disrupting critical biological processes by blocking them from interacting with healthy proteins, but in reality, that is much easier said than done.
One protein in our body can interact with hundreds of other proteins in many different ways. Those proteins can then interact with hundreds more, forming a complex network of protein-protein interactions called the interactome.
This becomes even more complicated when disease-causing DNA mutations are introduced into the mix. Some genes can be mutated in many ways to cause the same disease, meaning one condition can be associated with many interactomes arising from just one differently mutated protein.
Drug developers are left with tens of thousands of potential disease-causing interactions to pick from—and that's only after they generate the list based on the affected protein's physical structures.
Some scientists, especially the drug developers, are taking the help of artificial intelligence (AI) tools to identify the most promising protein-protein interactions more easily and speedily.
Their resulting database allows researchers to navigate the interactome for more than 10,500 diseases, from alopecia to von Willebrand Disease.
Researchers who identified a disease-associated mutation can input it into PIONEER to receive a ranked list of protein-protein interactions that contribute to the disease and can potentially be treated with a drug. Scientists can search for a disease by name to receive a list of potential disease-causing protein interactions that they can then go on to research. PIONEER is designed to help biomedical researchers who specialize in almost any disease across categories including autoimmune, cancer, cardiovascular, metabolic, neurological and pulmonary.
Part 1
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