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Comment by Dr. Krishna Kumari Challa on July 26, 2024 at 11:10am

These recent patients fell ill with the same strain identified in the study as circulating in dairy cows, leading the researchers to suspect that the virus likely originated from dairy farms in the same county.

While the virus does have the ability to infect and replicate in people, the efficiency of those infections is low.

The concern is that potential mutations could arise that could lead adaptation to mammals, spillover into humans and potential efficient transmission in humans in the future. 

It is therefore critical to continue to monitor the virus in affected animals and also in any potential infected humans.

 Diego Diel, Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle, Nature (2024). DOI: 10.1038/s41586-024-07849-4. www.nature.com/articles/s41586-024-07849-4

Part 2

Comment by Dr. Krishna Kumari Challa on July 26, 2024 at 11:08am

New study confirms mammal-to-mammal avian flu spread

A new study provides evidence that a spillover of avian influenza from birds to dairy cattle across several U.S. states has now led to mammal-to-mammal transmission—between cows and from cows to cats and a raccoon.

This is one of the first times that we are seeing evidence of efficient and sustained mammalian-to-mammalian transmission of highly pathogenic avian influenza H5N1.

Whole genome sequencing of the virus did not reveal any mutations in the virus that would lead to enhanced transmissibility of H5N1 in humans, although the data clearly shows mammal-to-mammal transmission, which is concerning as the virus may adapt in mammals.

So far, 11 human cases have been reported in the U.S., with the first dating back to April 2022, each with mild symptoms: four were linked to cattle farms and seven have been linked to poultry farms, including an outbreak of four cases reported in the last few weeks.

Part1

Comment by Dr. Krishna Kumari Challa on July 26, 2024 at 10:20am

The notion that moderate drinking leads to a longer, healthier life goes back decades. As an example, the scientists pointed to the "French paradox"—the idea, popularized in the 1990s, that red wine helps explain why the French enjoy relatively low rates of heart disease, despite a rich, fatty diet. That view of alcohol as an elixir still seems to be "ingrained" in the public imagination, Stockwell noted.

In reality, they said, moderate drinking likely does not extend people's lives—and, in fact, carries some potential health hazards, including increased risks of certain cancers. That's why no major health organization has ever established a risk-free level of alcohol consumption.

"There is simply no completely 'safe' level of drinking," the researchers confirm.

Stockwell, T., et al. Why do only some cohort studies find health benefits from low volume alcohol use? A systematic review and meta-analysis of study characteristics that may bias mortality risk estimates. Journal of Studies on Alcohol and Drugs (2024). DOI: 10.15288/jsad.23-00283. www.jsad.com/doi/10.15288/jsad.23-00283

Comment by Dr. Krishna Kumari Challa on July 26, 2024 at 10:18am

For the analysis,  researchers identified 107 published studies that followed people over time and looked at the relationship between drinking habits and longevity. When the researchers combined all the data, it looked like light to moderate drinkers (that is, those who drank between one drink per week and two per day) had a 14% lower risk of dying during the study period compared with abstainers.

Things changed, however, when the investigators did a deeper dive. There were a handful of "higher quality" studies that included people who were relatively young at the outset (younger than 55, on average) and that made sure former and occasional drinkers were not considered "abstainers." In those studies, moderate drinking was not linked to a longer life.

Instead, it was the "lower quality" studies (older participants, no distinction between former drinkers and lifelong abstainers) that did link moderate drinking to greater longevity.

"If you look at the weakest studies," the researchers said, "that's where you see health benefits."

Part 2

Comment by Dr. Krishna Kumari Challa on July 26, 2024 at 9:52am

Study debunks link between moderate drinking and longer life

Probably everyone has heard the conventional wisdom that a glass of wine a day is good for you—or you've heard some variation of it. The problem is that it's based on flawed scientific research, according to a new report in the Journal of Studies on Alcohol and Drugs.

Over the years, many studies have suggested that moderate drinkers enjoy longer lives with lower risks of heart disease and other chronic ills than abstainers do. That spurred the widespread belief that alcohol, in moderation, can be a health tonic. However, not all studies have painted such a rosy picture—and the new analysis sheds light on why.

In a nutshell, studies linking moderate drinking to health benefits suffer from fundamental design flaws, said lead researcher Tim Stockwell, Ph.D., a scientist with the Canadian Institute for Substance Use Research at the University of Victoria.

The major issue: Those studies have generally focused on older adults and failed to account for people's lifetime drinking habits. So moderate drinkers were compared with "abstainer" and "occasional drinker" groups that included some older adults who had quit or cut down on drinking because they'd developed any number of health conditions.

That makes people who continue to drink look much healthier by comparison, And in this case, the researchers noted, looks are deceiving.

Part 1

Comment by Dr. Krishna Kumari Challa on July 24, 2024 at 11:44am

Bear in mind, however, that an observational study like this can't definitively conclude that microplastics are causing the downstream heart effects; only that there is an association. The study did not consider other risk factors for cardiovascular disease, such as smoking, physical inactivity, and air pollution.
"Although we do not know what other exposures may have contributed to the adverse outcomes among patients in this study, the finding of microplastics and nanoplastics in plaque tissue is itself a breakthrough discovery that raises a series of urgent questions," such as how to reduce exposure, explained pediatrician, public health physician and epidemiologist Philip J. Landrigan, of Boston College, in an accompanying editorial.

Plastic production has exploded in the past two decades, only a fraction of which has been recycled, and yet rates of cardiovascular disease have been falling in some parts of the world, so more research is needed to understand the link between the two.

https://www.nejm.org/doi/10.1056/NEJMoa2309822

Part 3

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Comment by Dr. Krishna Kumari Challa on July 24, 2024 at 11:43am

With microplastics previously found coursing through people's bloodstream, the researchers were reasonably concerned about heart health. Lab-based studies suggest microplastics can trigger inflammation and oxidative stress in heart cells, and impair heart function, alter heart rate, and cause scarring of the heart in animals such as mice.

"Observational data from occupational-exposure studies [also] suggest an increased risk of cardiovascular disease among persons who are exposed to plastics-related pollution, including polyvinyl chloride, than that seen in the general population," Marfella and colleagues write.
In the study, patients with microplastics in their excised plaques were 4.5 times as likely to have experienced a stroke, non-fatal heart attack or died from any cause after 34 months than people who had no detectable microplastics in the plaques that surgeons had removed.

The amount of microplastics, and even smaller particles called nanoplastics, was measured using a technique called pyrolysis–gas chromatography–mass spectrometry, and their presence confirmed using another method, stable isotopes analysis, which can distinguish between the carbon of human tissues and that of plastics made from petrochemicals.

Microplastics were also visible under powerful microscopes: The researchers observed plastic fragments with jagged edges inside immune cells called macrophages, and within the fatty plaques. Examining the tissue samples, the team also found higher levels of inflammatory markers in patients with microplastics in their plaques.
Part 2

Comment by Dr. Krishna Kumari Challa on July 24, 2024 at 11:42am

Plastic Was Found Inside More Than 50% of Plaques From Clogged Arteries

Plastics are now everywhere, with tiny fragments found in several major organs of the human body, including the placenta.
Given how easily the microscopic particles infiltrate our tissues, it's vital that we learn exactly what kinds of risks they could pose to our health.
Researchers have been busy studying the effects of microplastics in mini-replicas of organs, and in mice, to get a sense of how they might impact the human body. However, the concentrations of microplastics used in those studies might not reflect people's real-world exposure, and few studies have been done in humans.

In March, a small study in Italy found shards of microplastics in fatty deposits surgically removed from patients who had an operation to open up their clogged arteries – and reported their health outcomes nearly 3 years later.

Removing fatty plaques from narrowed arteries in a procedure called a carotid endarterectomy reduces the risk of future strokes.

The team behind this recent study, led by Raffaele Marfella, a medical researcher at the University of Campania in Naples, wondered how the risk of stroke – as well as heart attacks and death – compared between patients who had microplastics in their plaques and those who did not.
Following 257 patients for 34 months, the researchers found nearly 60 percent of them had measurable amounts of polyethylene in plaques pulled from their fat-thickened arteries, and 12 percent also had polyvinyl chloride (PVC) in extracted fat deposits.

PVC comes in both rigid and flexible forms, and is used to make water pipes, plastic bottles, flooring, and packaging. Polyethylene is the most commonly produced plastic, used for plastic bags, films, and bottles, too.
Part 1

Comment by Dr. Krishna Kumari Challa on July 24, 2024 at 11:05am

Virus spreading in Latin America may cause stillbirths and birth defects
Brazilian Ministry of Health tells doctors to closely monitor pregnant women infected with the little-known Oropouche virus
Fears over viral infection during pregnancy
The 2015-2016 outbreak of the Zika virus in Brazil caused thousands of birth defects after women were infected during pregnancy; now the country is facing the same fears with the Oropouche virus. Brazil’s health ministry has reported four cases of microcephaly — a type of reduced brain development — in newborns of infected mothers and one fetal death that might be associated with the virus. The virus is transmitted by Culicoides paraensis, a tiny midge found across the Americas. Cases of Oropouche fever have surged in Brazil since late 2022. “The cases are worrisome and a sign to be alert,” says virologist Amilcar Tanuri.

https://www.science.org/content/article/virus-spreading-in-latin-am...

Comment by Dr. Krishna Kumari Challa on July 24, 2024 at 10:50am

Evidence of ‘Dark oxygen’ production from the sea floor

A chemical reaction could be producing oxygen by splitting water molecules, but its source of energy remains unknown.

The phenomenon was discovered in a region strewn with ancient, plum-sized formations called polymetallic nodules, which could play a part in the oxygen production by catalysing the splitting of water molecules, researchers suspect. The findings are published in Nature Geoscience.
Something is pumping out large amounts of oxygen at the bottom of the Pacific Ocean, at depths where a lack of sunlight makes photosynthesis impossible. The find has surprised scientists and the source remains a mystery. The oxygen might be generated by metal-rich mineral deposits, or nodules. To researchers’ surprise, they measured voltages of up to 0.95 volts across the surface of the nodules. It is possible that the nodules catalyse the splitting of water into oxygen and hydrogen, but more experiments are needed.

https://www.nature.com/articles/s41561-024-01480-8?utm_source=Live+...

https://www.nature.com/articles/d41586-024-02393-7?utm_source=Live+...

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