Comment

Comment by Dr. Krishna Kumari Challa on May 25, 2024 at 11:44am

Big brands are 'failing to curb plastic sachet use'

Small plastic sachets commonly used in low- and middle-income countries must be phased out and packaging reuse systems promoted, urge campaigners and waste pickers, as new analysis reveals major corporations have failed to curb their use.

Pocket-sized individual portions of goods ranging from shampoo to instant coffee have become popular in lower-income communities for their affordability.

An estimated 855 billion sachets are sold globally each year with Southeast Asia consuming nearly half of the total and this figure projected to rise to 1.3 trillion by 2027, according to environmental groups.

But the convenience of sachets comes with a heavy environmental cost as they end up as significant contributors to plastic pollution. Their commonly multi-layered design, using different materials, makes them hard to recycle.

Consumer goods giants Unilever, Nestlé and Procter & Gamble are among the biggest contributors to plastic sachet pollution in developing countries in Asia, despite promises to reduce plastic packaging, according to a multi-country environmental audit report.

It said some corporations were trying to deal with the waste problem by burning sachets as fuel, creating further pollution.

Environmental groups in Asia have long been demanding firms to phase out their sachet packaging as the resulting waste is deluging the region's landfills and waters.

Consumers, can you please help by avoiding these small plastic sachet based products?

Source: SciDev.Net

Comment by Dr. Krishna Kumari Challa on May 25, 2024 at 9:02am

Many plants and plant oils are high in monounsaturated fats but low in saturated fats. These include: oils from olives, peanuts, canola seeds, safflower seeds, and sunflower seeds, avocadoes, pumpkin seeds, sesame seeds, almonds,  cashews, peanuts and peanut butter, pecans.

Air pollution is a complex issue with no easy solutions. While research continues mitigating PM2.5 exposure, the current understanding of its impact on the digestive system highlights the far-reaching consequences of air pollution on human health. It underscores the need for continued efforts to reduce air pollution levels and develop strategies to protect ourselves from its detrimental effects.

Kezhong Zhang, Environmental PM2.5-triggered stress responses in digestive diseases, eGastroenterology (2024). DOI: 10.1136/egastro-2024-100063

Part 2

Comment by Dr. Krishna Kumari Challa on May 25, 2024 at 9:00am

How air pollution affects the digestive system

Fine air particles, less than 2.5 micrometers in diameter (PM_2.5), are a major air pollutant linked to various health problems. These particles can travel deep into the lungs and even enter the bloodstream when inhaled. Recent research suggests a major health concern: PM_2.5 exposure can also damage the digestive system, including the liver, pancreas, and intestines.

The work is published in the journal eGastroenterology. This recent research has been focused on how PM2.5 exposure triggers stress responses within the digestive system's cells. These stress responses involve specialized subcellular structures within cells called organelles, such as the endoplasmic reticulum (ER), mitochondria, and lysosomes. When PM2.5 disrupts these organelles, it creates a chain reaction within the cells that can lead to inflammation and other harmful effects.

The liver, a major organ for detoxification and metabolism, is particularly susceptible to PM_2.5 damage. Studies have shown that PM_2.5 exposure can lead to a cascade of problems within the liver, including inflammation, stress responses, and damage to the organelles, and disrupted energy metabolism. These effects can contribute to the development of non-alcoholic fatty liver disease (NASH) and type 2 diabetes.

PM_2.5 exposure does not stop at the liver. It can also harm the pancreas and intestines. Studies have linked PM_2.5 to an increased risk of pancreatic impairment in people with diabetes, as well as damage to intestinal cells and an increase in their permeability. This increased permeability can lead to a variety of digestive issues.

Researchers are exploring whether dietary or pharmaceutical interventions can mitigate PM_2.5 damage. Interestingly, some studies suggest that certain nutrients, like monounsaturated fatty acids and vitamins, may offer some protection against the harmful effects of PM_2.5.

Part 1

Comment by Dr. Krishna Kumari Challa on May 25, 2024 at 7:09am

Replicated, long-term studies from natural populations, including research on the famous Darwin's finches, are rare.

Because most of this work is restricted to one or few populations, it is difficult to draw inferences on repeatability among multiple evolutionary independent populations.

Such studies are challenging to implement not only because they take concerted effort, but also because you can't rush time.

Patrik Nosil et al, Evolution repeats itself in replicate long-term studies in the wild, Science Advances (2024). DOI: 10.1126/sciadv.adl3149. www.science.org/doi/10.1126/sciadv.adl3149

Part 2

Comment by Dr. Krishna Kumari Challa on May 25, 2024 at 7:08am

Biologists observe recurring evolutionary changes, over time, in stick insects

A long-standing debate among evolutionary scientists goes something like this: Does evolution happen in a predictable pattern or does it depend on chance events and contingency? That is, if you could turn back the clock, as celebrated scientist Stephen Jay Gould (1941–2002) described in his famous metaphor, "Replaying the Tape of Life," would life on Earth evolve, once again, as something similar to what we know now, or would it look very, very different?

Now researchers  report evidence of repeatable evolution in populations of stick insects in the paper "Evolution repeats itself in replicate long-term studies in the wild," in Science Advances. 

The team examined three decades of data on the frequency of cryptic color-pattern morphs in the stick insect species Timema cristinae in ten naturally replicate populations in California. T. cristinae is polymorphic in regard to its body colour and pattern. Some insects are green, which allows the wingless, plant-feeding insect to blend in with California lilac (Ceanothus spinosus) shrubs. In contrast, green striped morphs disappear against chamise (Adenostoma fasciculatum) shrubs.

Hiding among the plants is one of T. christinae's key defenses as hungry birds, such as scrub jays, are insatiable predators of the stick insects.

Bird predation is a constant driver shaping the insects' organismal traits, including coloration and striped vs. non-striped.

Scientists observed predictable 'up-and-down' fluctuations in stripe frequency in all populations, representing repeatable evolutionary dynamics based on standing genetic variation.

A field experiment demonstrates these fluctuations involved negative frequency-dependent natural selection (NFDS), where cryptic colour patterns are more beneficial when rare rather than common. This is likely because birds develop a 'search image' for very abundant prey.

At short time scales, evolution involving existing variations can be quite predictable. You can count on certain drivers always being there, such as birds feeding on the insects.

But at longer time scales, evolutionary dynamics become less predictable.

The populations might experience a chance event, such as a severe drought or a flooding event, that disrupts the status quo and thus, the predictable outcomes.

On long time scales, a new mutation in the species could introduce a rare trait. That's about as close to truly random as you can get.

Rare things are easily lost by chance, so there's a strong probability a new mutation could disappear before it gains a stronghold. 

Indeed, another species of Timema stick insect that also feeds on chamise either never had or quickly lost the mutations making the cryptic stripe trait. Thus, the evolution of stripe is not a repeatable outcome of evolution at this long scale.

Part 1

Comment by Dr. Krishna Kumari Challa on May 24, 2024 at 12:41pm

How gut microbes drive tumour growth
Scientists have long known that obese people have poorer cancer survival rates. Now they have some idea why. A high-fat diet increases the number of Desulfovibrio bacteria in the gut of mice. These release leucine, an amino acid, which encourages the proliferation of a kind of cell that suppresses the immune system. With a suppressed immune system, tumour growth can increase. In breast cancer patients, poorer outcomes were seen for women with higher body-mass index, who also had higher levels of Desulfovibrio bacteria in their gut and leucine in their blood. It’s a provocative finding that will open up new avenues that we should be thinking about.

https://www.pnas.org/doi/10.1073/pnas.2306776121?utm_source=Live+Au...

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Biggest risk factors for disease spread A meta-analysis of five ways that humanity’s environmental footprint spreads disease — biodiversity loss, chemical pollution, climate change, invasive species and deforestation/urbanization — suggests that conserving biodiversity, controlling invasive species and lowering greenhouse-gas emissions would reduce disease spread the most. This evidence can be used in international policy to spur action on climate change and biodiversity loss due to their negative impacts on disease.

https://www.nature.com/articles/s41586-024-07380-6?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa on May 24, 2024 at 11:52am

Micro-ballistics research has shown metals hardening as they are heated, under extreme strain rates.

Comment by Dr. Krishna Kumari Challa on May 24, 2024 at 11:39am

Strange  bacteria defy textbooks by writing new genes

Bacterial defensive systems scramble the standard workflow of life.

Genetic information usually travels down a one-way street: genes written in DNA serve as the template for making RNA molecules.... That tidy textbook story got a bit complicated in 1970 when scientists discovered that some viruses have enzymes called reverse transcriptases, which scribe RNA into DNA — the reverse of the usual traffic flow.

Now, scientists have discovered an even weirder twist. A bacterial version of reverse transcriptase reads RNA as a template to make completely new genes written in DNA. These genes are then transcribed back into RNA, which is translated into protective proteins when a bacterium is infected by a virus. By contrast, viral reverse transcriptases don’t make new genes; they merely transfer information from RNA to DNA.

This is a crazy molecular biology!

https://www.nature.com/articles/d41586-024-01477-8?utm_source=Live+...

Part 2

The discovery that reverse transcriptase — which has previously been known only for copying genetic material — can create completely new genes has left other researchers gobsmacked.

Comment by Dr. Krishna Kumari Challa on May 24, 2024 at 11:37am

Bizarre bacteria scramble workflow of life
Bacteria have stunned biologists by reversing the usual flow of information. Typically genes written in DNA serve as the template for making RNA molecules, which are then translated into proteins. Some viruses are known to have an enzyme that reverses this flow by scribing RNA into DNA. Now scientists have found bacteria with a similar enzyme that can even make completely new genes — by reading RNA as a template. These genes create protective proteins when a bacterium is infected by a virus. It should change the way we look at the genome.

https://www.biorxiv.org/content/10.1101/2024.05.08.593200v1

Part 1

Comment by Dr. Krishna Kumari Challa on May 24, 2024 at 11:18am

Atomic-resolution imaging shows why ice is so slippery

A team of physicists  has uncovered the reason behind the slipperiness of ice. In their study, published in the journal Nature, the group used atomic force microscopy to get a closer look at the surface of ice at different temperatures.

Prior research and day-to-day experiences  have shown that ice is slippery, even when temperatures are well below the freezing point. Research has suggested this is because of a pre-melt coating that develops at the surface, which serves as a lubricant.

In this new study, the research team used an atomic force microscope fitted with a carbon monoxide atom on its tip to get a better look at the structure of normal ice and its pre-melt coating.

The researchers began by chilling ice inside the microscope chamber to -150°C and then using the microscope to look at its atomic structure. They could see that the internal ice (known as ice Ih), and the ice at the surface were different.

The ice Ih, as expected, was arranged in stacked hexagons. The ice on the surface, by contrast, was only partially hexagonal. The researchers also found defects in the ice at the border between the two types of ice that occurred as the different ice shapes met one another.

The researchers then raised the temperature in the chamber slightly, which resulted in more disorder as the differences in shape became more pronounced. The team then created a simulation showing how such disorder would impact the surface as a whole unit—it showed the disorder expanding all the way across the surface, giving the ice a liquid-like appearance that would be slippery if trod upon.

 Jiani Hong et al, Imaging surface structure and premelting of ice Ih with atomic resolution, Nature (2024). DOI: 10.1038/s41586-024-07427-8

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