Comment

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 12:18pm

Temperature sensing is an essential function of all living organisms. Animals, including humans, use so-called transient receptor potential (TRP) channel molecules to sense temperature. These channel molecules are ion channel proteins that transport ions across cell membranes. They also act as temperature-sensing molecules because their function changes in response to temperature variation. By contrast, plants do not have temperature-sensing molecules such as TRP channels. Therefore, the mechanism by which plants sense temperature has been a mystery.

In this study, the research group focused attention on the fact that S. saman, which performs nyctinasty by folding its leaves at night and opening them in the morning, also folds its leaves when it rains. According to another report in 2018, nyctinasty in S. saman is regulated by SPORK2, an ion channel found in cells at the base of the leaf. This time, the research group found that this leaf folding is also triggered by temperature changes. They also found that SPORK2, like the TRP channel, changes its ion transport activity in response to temperature. Genes similar to SPORK2 (orthologs: genes derived from a common ancestral gene through species divergence) are found in other plants aside from S. saman.

Ion channels are proteins that form holes in the cell membrane through which ions are allowed to pass. The TRP channel creates holes for sodium and calcium ions, whereas SPORK2 generates holes for potassium ions. The activities of SPORK2 orthologs in Arabidopsis thaliana were also examined and they were found to be temperature-sensitive ion channels.

Crop production has been severely affected by climate change. Shedding light on the mechanisms by which plants adapt to temperature changes is an urgent issue for stable food production.

https://www.cell.com/current-biology/abstract/S0960-9822(23)01458-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982223014586%3Fshowall%3Dtrue

Part 2

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 12:16pm

Researchers discover plant temperature sensor molecule: The Rain Tree folds its leaves in the rain

A research group led by Professor Minoru Ueda and Graduate Student Yuki Muraoka of the Graduate School of Science at Tohoku University announced that they have clarified the identity of temperature-sensitive ion channels in plants. Focusing on the phenomenon of the legume tree Samanea saman (also known as the Rain Tree), which folds its leaves when it rains, the researchers found that a decrease in leaf temperature triggers the folding movement. Aside from the temperature effect on leaf folding, the research group also found that the ion channel SPORK2, which is present in cells at the base of the leaf, functions as a sensor molecule to detect temperature changes. These findings are expected to lead to the elucidation of the temperature-sensing mechanism in plants and were published in the November 28 issue of the journal Current Biology.

 The phenomenon of rain tree leaves closing when it rains has led to the discovery of temperature sensors in plants.
Provided by Tohoku University

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Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 9:21am

Astronauts completed health screenings and a questionnaire about their headache history before the flight. During space flight, astronauts filled out a daily questionnaire for the first seven days and a weekly questionnaire each following week throughout their stay in the space station.

The astronauts reported 378 headaches in flight. Researchers found that 92% of astronauts experienced headaches during flight compared to just 38% of them experiencing headaches prior to flight.

Of the total headaches, 170, or 90%, were tension-type headache and 19, or 10%, were migraine.

Researchers also found that headaches were of a higher intensity and more likely to be migraine-like during the first week of space flight. During this time, 21 astronauts had one or more headaches for a total of 51 headaches. Of the 51 headaches, 39 were considered tension-type headaches and 12 were migraine-like or probable migraine.

In the three months after return to Earth, none of the astronauts reported any headaches.

This research does not prove that going into space causes headaches; it only shows an association. A limitation of the study was that astronauts  reported their own symptoms. 

https://www.neurology.org/doi/10.1212/WNL.0000000000209224

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 9:18am

Astronauts experience 'space headaches'

Space travel and zero gravity can take a toll on the body. A new study has found that astronauts with no prior history of headaches may experience migraine and tension-type headaches during long-haul space flight, which includes more than 10 days in space. The study was published in Neurology.

Changes in gravity caused by space flight affect the function of many parts of the body, including the brain.

The vestibular system, which affects balance and posture, has to adapt to the conflict between the signals it is expecting to receive and the actual signals it receives in the absence of normal gravity. This can lead to space motion sickness in the first week, of which headache is the most frequently reported symptom. This new study shows that headaches also occur later in space flight and could be related to an increase in pressure within the skull.

The study involved 24 astronauts from the European Space Agency, the U.S. National Aeronautics and Space Administration (NASA) and the Japan Aerospace Exploration Agency. They were assigned to International Space Station expeditions for up to 26 weeks from November 2011 to June 2018.

Prior to the study, nine astronauts reported never having any headaches and three had a headache that interfered with daily activities in the last year. None of them had a history of recurrent headaches or had ever been diagnosed with migraine.

Of the total participants, 22 astronauts experienced one or more episodes of headache during a total of 3,596 days in space for all participants.

Part 1

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 9:07am

With this platform, you can bust biofilms without surgically debriding infections, which can be necessary when using antibiotics. Plus, this method could treat patients if they are allergic to antibiotics or are infected by strains that are resistant to medication. The fact that this method is antibiotic-free is a huge bonus. 

The researchers assessed their strategy by applying the gold nanoparticles atop S. mutans-infected teeth from ex vivo rat jaws.

In a photoacoustic imaging test on the teeth, the nanoparticles emitted signals that came through loud and clear, allowing the team to see precisely where biofilms had taken up the dextran-coated particles on the teeth.

Then, to evaluate the particles' therapeutic effect, they irradiated the teeth with a laser. For comparison, they treated other infected teeth samples with the topical antiseptic chlorhexidine.

The team observed a stark contrast in the outcomes of the two treatments, with the photothermal therapy being nearly 100% effective at killing biofilms, while chlorhexidine did not significantly diminish the viability of bacteria.

The treatment method is especially fast for the oral infection.

Evaluations conducted on mice with open wounds in their skin, infected with Staphylococcus aureus, were similarly successful, as heat generated by nanoparticles greatly outperformed another antimicrobial agent called gentamicin. Here, the researchers also measured and noted a rise in temperature of 20°C localized to the biofilm, not causing any apparent damage to surrounding tissue.

 Maryam Hajfathalian et al, Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models, Journal of Clinical Investigation (2023). DOI: 10.1172/JCI168485

Part 2

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 9:07am

Sugar-coated gold nanoparticles can quickly eliminate bacterial infections, no antibiotics required

If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. Oral biofilms, also known as plaques, formed by bacteria such as Streptococcus mutans can cause significant tooth decay. Wound infections, which are commonly caused by Staphylococcus bacteria, can greatly delay the healing process. In either case, the densely packed network of proteins and carbohydrates within biofilms can prevent antibiotics from reaching microbes throughout the affected area.

But that isn't the extent of the issue posed by biofilms. Not only are they difficult to remove, but they are troublesome to discern in the first place.

These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slime, are difficult to dislodge. A new strategy may offer a simple way to break up the muck and destroy the bacteria.

This new research identified a solution to knock out both problems with one stone: gold.

Researchers have developed sugar-coated gold nanoparticles that they used to both image and destroy biofilms.

Gold is nontoxic and readily converts energy from light sources into heat, making it a prime candidate for photothermal therapy, a strategy that utilizes the heat from nanoparticles to kill nearby pathogens. In addition to generating heat, the nanoparticles emit detectable ultrasound waves in response to light, meaning that gold particles can be visualized using a technique called photoacoustic imaging.

In the new study, the authors encapsulated gold spheres within larger golden cage-shaped nanoparticles to optimize their response to light for both therapeutic and imaging purposes. To make the particles appealing to bacteria, they coated them in dextran, a carbohydrate that is a common building block of biofilms.

In a study published in the Journal of Clinical Investigation, the authors demonstrated the diagnostic and therapeutic potential of the nanoparticles on the teeth and wounded skin of rats and mice, eliminating the biofilms in as little as one minute and outperforming common antimicrobials. 

Part 1

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:21am

Study finds no persistent cough in four out of five individuals with tuberculosis in Africa and Asia

More than 80% of patients with tuberculosis, the world's most deadly infection, do not have a persistent cough, despite this being seen as a key symptom of the disease. The infection is predominantly transmitted by coughing, but probably also through simply breathing.

Researchers analyzed data on more than 600,000 individuals in Africa and Asia and found that 82.8% of those with tuberculosis had no persistent cough and 62.5% had no cough at all. These results are published today in The Lancet Infectious Diseases.

The  results indicate the probable reason why, despite huge efforts to diagnose and treat the disease, the tuberculosis (TB) burden across Africa and Asia is hardly declining.

A persistent cough is often the entry point for a diagnosis, but if 80% of those with TB don't have one, then it means that a diagnosis will happen later, possibly after the infection has already been transmitted to many others, or not at all.

 Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual participant data meta-analysis, The Lancet Infectious Diseases (2024). DOI: 10.1016/S1473-3099(24)00011-2

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:15am

Progesterone protects babies from preterm birth in women with a short cervix, research shows

Preterm birth, defined as birth prior to 37 weeks, remains a serious problem with far-reaching consequences. Approximately 13.5 million children worldwide are born preterm each year. Children who are born preterm are at higher risk for, both physical and developmental, lifelong complications. Preventing preterm birth is therefore a major priority.

At around 20 weeks of pregnancy women with a short cervix have an increased risk of preterm birth. Preventing preterm birth in pregnant women with a short cervix is a crucial step in protecting the health of the child. Research now shows that, in pregnant women with a short cervix around 20 weeks, progesterone is better than a cervical pessary at reducing the risk of severe preterm birth. This study was published in the BMJ.

This is an important improvement that can contribute to the reduction of preterm births and the associated complications, such as an increased risk of infant mortality and long-term health problems for the child.

Researchers investigated the best treatment for women with a cervical length shorter than 25 mm at the 20-week ultrasound scan. A total of 25 centers across the Netherlands participated in this study.

The results of this study show that progesterone is more effective than a pessary in reducing extreme preterm birth. This study underlines the importance of measuring the length of the cervix during the 20-week ultrasound scan and informing women with a cervix shorter than 25 mm about the possibility of treatment with progesterone. For women with a cervical length between 25 mm and 35 mm, there was no significant difference in the number of complications due to preterm birth between the group taking progesterone and the group using a pessary.

Cervical pessary versus vaginal progesterone in women with a singleton pregnancy, a short cervix, and no history of spontaneous preterm birth at less than 34 weeks' gestation: open label, multicentre, randomised, controlled trial, The BMJ (2024). DOI: 10.1136/bmj-2023-077033

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:04am

Study finds rerouting of airplanes to reduce contrails not as expensive as thought

A small team of environmental scientists has found via simulations that rerouting commercial airplanes to reduce contrails would be less expensive than previously thought. In their study, published in the journal Environmental Research: Infrastructure and Sustainability, the group used data from prior studies to create simulations of airplanes routed to prevent the development of contrails.

Prior research has shown that high-altitude airplanes are disproportionate contributors to climate change due to the multiple ways they impact the environment. In addition to the greenhouse gases they emit, jets that fly at high altitudes can also create contrails, white vapor trails of ice, water vapour and particulate matter.

When several planes fly in the same general area over the same period of time, the contrails can combine, leading to the formation of cirrus clouds, which can act like a blanket, holding in heat. Prior research has shown that this accounts for approximately 35% of the total aviation contribution to global warming.

Prior research has also shown that just 2%–10% of flights create approximately 80% of contrails. And because rerouting of jet planes can prevent the creation of contrails, researchers have suggested that the commercial aviation industry could greatly reduce its environmental footprint by doing so. But some argue that doing so would be too expensive to justify its cost.

To find out if that might be the case, American Airlines, working with another team of researchers last summer, used weather and satellite data to create software models and AI prediction tools to determine whether it was feasible to divert planes from airspace that would lead to contrail formation. They found that it appeared possible to reduce contrail formation by approximately 54%.

In this new effort, the research team used the same data to create simulations of 85,000 high-altitude flights and found that reducing contrails by 73% would raise fuel costs by just 0.11% and overall operating costs by just 0.08%. They also noted that rerouting aircraft under such a scenario would only involve 14% of all flights.

 Alejandra Martin Frias et al, Feasibility of contrail avoidance in a commercial flight planning system: an operational analysis, Environmental Research: Infrastructure and Sustainability (2024). DOI: 10.1088/2634-4505/ad310c

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 6:58am

Jets release heat, water vapour, and particulate matter that can produce thin clouds in the sky, known as “contrails”. When numerous flights pass through some areas, these contrails can form clouds that absorb radiation escaping from the surface, acting as blankets floating above the Earth.

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