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Comment by Dr. Krishna Kumari Challa on November 16, 2024 at 2:58pm

Genes of ancient animal relatives used to grow a mouse

An international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals.

This breakthrough reshapes our understanding of the genetic origins of stem cells, offering a new perspective on the evolutionary ties between animals and their ancient single-celled relatives. The research is published in the journal Nature Communications.

In an experiment that sounds like science fiction,  researchers used a gene found in choanoflagellates, a single-celled organism related to animals, to create stem cells which they then used to give rise to a living, breathing mouse.

Choanoflagellates are the closest living relatives of animals, and their genomes contain versions of the genes Sox and POU, known for driving pluripotency—the cellular potential to develop into any cell type—within mammalian stem cells. This unexpected discovery challenges a longstanding belief that these genes evolved exclusively within animals.

By successfully creating a mouse using molecular tools derived from our single-celled relatives, we're witnessing an extraordinary continuity of function across nearly a billion years of evolution. The study implies that key genes involved in stem cell formation might have originated far earlier than the stem cells themselves, perhaps helping pave the way for the multicellular life we see today.

Ya Gao et al, The emergence of Sox and POU transcription factors predates the origins of animal stem cells, Nature Communications (2024). DOI: 10.1038/s41467-024-54152-x

Comment by Dr. Krishna Kumari Challa on November 16, 2024 at 2:47pm

Astronomers discover two galaxies aligned in a way where their gravity acts as a compound lens

An international team of astronomers has discovered an instance of two galaxies aligned in a way where their gravity acts as a compound lens. The group has written a paper describing the findings and posted it on the arXiv preprint server.

Prior research has led to many findings of galaxies, or clusters of them, bending light in ways that were predicted by Einstein's theory of general relativity. Astronomers have noted that some of them work as imperfect lenses, distorting the light behind them in interesting ways.

Some researchers have also noted that elliptical galaxies can serve as a lens, serving to brighten the light behind them. In this new effort, the research team has found, for the first time, two galaxies that align in a way that allows their gravity to work as a compound lens.

A compound lens, as its name suggests, is made up of two lenses. Those made artificially are cemented together and work to correct each other's dispersion. In the astronomical case, a compound lens can be made by the dual effects of two galaxies lined up next to one another just right.

The researchers note that when the system, J1721+8842, was first discovered, it was believed that there was just one elliptical galaxy bending the light from a quasar behind it. In analyzing data over a two-year period, the researchers of this new effort found variations in the quasar imagery. They also found small bits of light that, at first glance, appeared to be duplicates from a single source.

A closer look revealed that they matched the light from the main quartet of lights—a finding that showed that all six bits of light were from the same source. Prior research had suggested such an image could be the result of a natural compound lens.

When adding data from the James Webb Space Telescope, the team found that a reddish ring that was mixed with the other lights and was thought to be an Einstein ring was, in reality, a second lensing galaxy. The researchers next built a computer model and used it to confirm that the observation they had made was indeed that of a compound lens.

F. Dux et al, J1721+8842: The first Einstein zig-zag lens, arXiv (2024). DOI: 10.48550/arxiv.2411.04177

Comment by Dr. Krishna Kumari Challa on November 16, 2024 at 2:41pm

Physicists create the first fully mechanical qubit

A team of physicists  has built the first-ever working mechanical qubit. In their paper published in the journal Science, the group describes their novel idea for creating such a qubit and how well it has worked during testing.

Researchers think quantum computers will be able to solve many types of problems that are beyond the ability of classical computers. And while much progress has been made, the goal has still not been fully realized. One of the major sticking points is the problem of virtual qubits, such as those made using electromagnetics, which produce errors that must be corrected. The research team found another way around the problem—using mechanical qubits instead.

Instead of representing data with only ones and zeroes, qubits are able to store data in a superposition of both states. For this new study, the researchers built what they describe as a membrane similar to a drum skin that can hold information as a steady state, a vibrating state or a state that is both at once.

Noting that the real problem with virtual qubits is their short duration (they pop into existence and are gone in a flash), the researchers turned to something that would last much longer—a piezoelectric disk fixed to a sapphire base. They used it as a mechanical resonator. They then attached a qubit made of a superconducting material fixed to its own sapphire base, using a special fabrication technique they developed.

The result was a qubit with coherence times that were based on the type of superconductor used and were on average better than hybrid or virtual qubits used in other systems.

Yu Yang et al, A mechanical qubit, Science (2024). DOI: 10.1126/science.adr2464

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 11:15am

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 10:34am

Human induced evolution

A native New Zealand insect that once mimicked its toxic neighbor has changed color in deforested areas, in a striking example of human-induced evolution.

The long-tailed stonefly, Zelandoperla, had a clever strategy to avoid predation from birds: it mimicked the appearance of a uniquely toxic stonefly, Austroperla, a forest dweller that deters predators by producing cyanide.

Researchers  have found that in deforested areas without Austroperla in the picture, and with fewer bird predators, some Zelandoperla have given up their guise.
The findings highlight "the possibility for populations to adapt rapidly in the wake of sudden environmental change," the team writes in their published paper.

While the long-tailed stonefly has no toxins of its own, it has managed to pull off a convincing impersonation of Austroperla using its genetic toolkit, which colored some of the insects a dark shade of ebony.

The disguise worked to deter their feathered predators, which, unable to tell the difference, steered clear of both the toxic stonefly and its mimic.

But Austroperla is a forest creature: it lives in streams where it feeds on leaves and woody debris. In deforested areas, its preferred food sources are lacking, and Austroperla has become less common.

The removal of forests since humans arrived has removed the poisonous species. 
As a result, in deforested regions the mimicking species has abandoned this strategy – as there is nothing to mimic – instead evolving into a different colour.

The scientists used a combination of field observations, predation experiments, and gene map analysis to show the insect's response to human-driven change.

https://www.science.org/doi/10.1126/science.ado5331

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 10:05am

The numbers from the United States are far more disturbing, with a 2020 report showing that between 2013 and 2017, younger-onset dementia in 30- to 44-year-olds had spiked by 373%.

All age groups recorded an increase, with a 311% rise in the 45–54 age group, and a 143% rise for 55–64s, but it was the Millennials and Gen Xers who were the hardest hit.

Some people cite the improvement in diagnostic techniques as being behind this change, but if that were the case, we would be seeing a similar increase across all ages. We aren't.
The report did not speculate on the cause for this dramatic increase in younger-onset dementia. Still, there is nothing else that has happened in the past 10 years that can explain this change apart from the global rise to dominance of the smartphone from about 2012.

We know that people with lower cognitive capacity are more susceptible to dementia.

We know overusing smartphones can result in lower cognitive capacity.

We may argue that correlation is not causation, but the correlation between lead in water and problems with children's brain development seen across the world from the mid-20th century was enough for governments to spend the equivalent of millions of dollars to replace all our water pipes.

Younger-onset dementia rates have risen at the same time as smartphones have taken over every part of our lives, and dismissing this as a coincidence will not address the problem.

Screen use may or may not be the original cause of the problem, but the fact that excessive and ongoing screen use leads to changes in the brain means there is a relationship that warrants urgent further investigation.

https://lighthouse.mq.edu.au/article/november-2024/opinion-we-need-...

Part 2

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Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 10:04am

We need to talk about what smartphones are doing to kids' brains, say experts

We know there are links between young people overusing devices and a decline in cognitive abilities, as well as problems with attention, focus and memory.

Researchers  recently published a review and meta-analysis of 34 studies looking at neuropsychological deficits in children and teenagers who had screen-use disorders—basically what can be classified as screen addictions.

Their findings showed strong evidence of impacts on attention, focus and executive functioning in these young people, but also changes in their brains that were visible on scans, with the loss of gray and white matter in areas of the frontal lobe that are associated with learning and memory.

Yes, you read that correctly.

Overuse can result in young people losing brain capacity.

These studies relate to the roughly 3% of teenagers who are classified as having a clinical screen overuse disorder, but the latest figures show the average Australian teenager is spending four to six hours a day on social media, and a total of up to eight hours a day using screens for leisure.

Recent research from the University of North Carolina shows brain changes related to habitual checking of social media in Grade 6 and 7 students over three years. A third of the children—those who were frequently checking their feeds—showed significant changes in brain areas involved in emotion, motivation and cognition.

Brains are very much a use-it-or-lose-it organ: if you challenge yourself through thinking, problem-solving and learning, you develop new connections in your brain. If you don't challenge yourself, not only do new connections not form, but the old ones start to die off.

Dementia might be thought of as an old person's disease, but younger people can also be affected. Early onset dementia usually affects adults aged between 30 and 65, but there are rare cases of people being diagnosed in their 20s. In the past, the majority of cases of younger-onset dementia were believed to be inherited.

Part 1

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 9:35am

Toxic smog smothering India's capital smashes WHO limit

Residents of India's capital New Delhi choked in a blanketing toxic smog this week as worsening air pollution surged past 50 times the World Health Organization's recommended daily maximum.

Many in the city cannot afford air filters, nor do they have homes they can effectively seal from the misery of foul smelling air blamed for thousands of premature deaths.

Cooler temperatures and slow-moving winds trap deadly pollutants each winter, stretching from mid-October until at least January.

At dawn on Wednesday, "hazardous" pollutant levels in parts of the sprawling urban area of more than 30 million people topped 806 micrograms per cubic meter, according to monitoring firm IQAir.

That is more than 53 times the World Health Organization recommended daily maximum of fine particulate matter—dangerous cancer-causing microparticles known as PM2.5 pollutants that enter the bloodstream through the lungs.

By midday, when air usually is at its best, it eased to about 25-35 times above danger levels, depending on different districts.

Now breathing in Delhi has become  like "smoking cigarettes". Older people have difficulties breathing. It is particularly punishing for babies, children and the elderly.

The city is blanketed in acrid smog each year, primarily blamed on stubble burning by farmers in neighboring regions to clear their fields for plowing, as well as factories, Diwali fire works and traffic fumes.

But a report by The New York Times this month, based on air and soil samples it collected over five years, revealed the dangerous fumes also spewing from a power plant incinerating the city's landfill garbage mountains.

Experts the newspaper spoke to said that the levels of heavy metals found were "alarming".

Swirling white clouds of smog also delayed several flights across northern India.

The India Meteorological Department said that at least 18 regional airports had a visibility lower than 1,000 meters (1,093 yards)—dropping below 500 meters in Delhi.

India's Supreme Court last month ruled that clean air was a fundamental human right, ordering both the central government and state-level authorities to take action.

But politicians are accused of not wanting to anger key figures in their constituencies, particularly powerful farming groups and industrialists.

City authorities have launched some initiatives to tackle pollution, which have done little in practice.

The choking carbon smog across Delhi came as researchers warned that planet-warming fossil fuel emissions would hit a record high this year, according to new findings from an international network of scientists at the Global Carbon Project.

Researchers said increases in CO₂ emissions from India—as well as growth in international aviation—drove emissions up.

It found no sign the world was moving away from fossil fuels as planned.

Source: News agencies

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 9:08am

These results support the importance of early identification of individuals exhibiting accelerated brain atrophy and certain unfavorable biomarkers. By recognizing when higher risk is present, preventive intervention strategies can be optimized to delay or hopefully even prevent the onset of MCI.

Yuto Uchida et al, Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.41505

 Shohei Fujita, Optimizing Strategies to Prevent Cognitive Decline With 20-Year Brain Imaging, JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.41466

Part 2

Comment by Dr. Krishna Kumari Challa on November 14, 2024 at 9:07am

Indicators of an aging brain

Researchers, working with the Biomarkers for Older Controls at Risk for Dementia (BIOCARD) cohort, have found that certain factors are linked to faster brain shrinkage and quicker progression from normal thinking abilities to mild cognitive impairment (MCI). People with type 2 diabetes and low levels of specific proteins in their cerebrospinal fluid showed more rapid brain changes and developed MCI sooner than others.

Long-term studies tracking brain changes over many years are rare but valuable. Previous research mostly provided snapshots in time, which can't show how individual brains change over the years. By following participants for up to 27 years (20-year median), this study offers new insights into how health conditions might speed up brain aging.

In a study, "Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment," published in JAMA Network Open, researchers used the BIOCARD cohort to examine risk factors associated with the acceleration of brain atrophy and progression from normal cognition to MCI. An Invited Commentary is also available.

 A total of 185 participants, averaging 55 years old at the start and all cognitively normal, were selected. They underwent brain scans and tests of their cerebrospinal fluid over 20 years, measuring changes in brain structures and levels of proteins associated with Alzheimer's disease.

Findings showed that high rates of white matter shrinkage and enlargement of the brain's ventricles (fluid-filled spaces) were significant predictors of earlier MCI onset. Specifically, white matter atrophy was associated with an 86% higher risk and ventricular enlargement with a 71% higher risk of progressing to MCI.

Individuals with diabetes showed an average 41% higher risk of progressing from normal cognition to MCI compared to individuals without.
A low ratio of amyloid β peptides Aβ42 to Aβ40 in cerebrospinal fluid was associated with a 48% higher risk of developing MCI. This ratio acts as a biomarker for Alzheimer's disease, where an imbalance between these two forms of amyloid beta proteins is linked to the formation of harmful plaques in the brain.

When participants had both diabetes and a low Aβ42 to Aβ40 ratio, their risk of progressing to MCI increased by 55%, demonstrating that these two factors together significantly heighten the likelihood of cognitive decline.

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