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Comment by Dr. Krishna Kumari Challa on June 26, 2024 at 9:04am

With this large study, the researchers asked two questions. One is, 'What are the roles of species and strains that make up the gut microbiome in type 2 diabetes?' The other question is, 'What are these microbes doing?'"

When they analyzed this data, they found a relatively consistent set of microbial species linked to type 2 diabetes across their study populations. Many of those species have never been reported before.

To understand the role of these microbes in the gut, the team analyzed species' functional abilities. Different strains of a microbial species can have varied functions, like the ability to make a specific amino acid. The team found that certain strains had functions that may be linked to varied T2D disease risk.

One major functional difference they saw was that a strain of Prevotella copri—a common microbe in the gut that has the capacity to produce large amounts of branched-chain amino acids (BCAAs)—was more commonly seen in diabetes patients' gut microbiomes. Previous studies have shown that people with chronically high blood levels of BCAAs have a higher risk of obesity and T2D.

The researchers also found evidence suggesting that bacteriophages—viruses that infect bacteria—could be driving some of the changes they detected within certain strains of gut bacteria.

This could mean that the virus infects the bacteria and changes its function in a way that increases or decreases type 2 diabetes risk, but more work is needed to understand this connection.

In another analysis, the team studied a small subset of samples from patients newly diagnosed with T2D to assess microbiomes that are less likely to have been impacted by medication use or long-term high glucose status. Their results were similar to their larger findings.

The researchers firmly think that changes in the gut microbiome cause type 2 diabetes. The changes to the microbiome may happen first, and diabetes develops later, not the other way around—although future prospective or interventional studies are needed to prove this relation firmly. This is just one study.

If these microbial features are causal, we can find a way to change the microbiome and reduce type 2 diabetes risk. The microbiome is amenable to intervention—meaning you can change your microbiome, for example, with dietary changes, probiotics, or fecal transplants.

Part 2

Comment by Dr. Krishna Kumari Challa on June 26, 2024 at 8:58am

Study links gut microbiome changes to increased risk of type 2 diabetes

The largest and most ethnically and geographically comprehensive investigation to date of the gut microbiome of people with type 2 diabetes (T2D), prediabetes, and healthy glucose status has found that specific viruses and genetic variants within bacteria correspond with changes in gut microbiome function and T2D risk.

The microbiome is highly variable across different geographic locations and racial and ethnic groups. If you only study a small, homogeneous population, you will probably miss something.

The gut microbiome's relationship to complex, chronic, heterogeneous diseases like T2D is quite subtle. Much like studies of large human populations have been crucial for understanding human genetic variation, large and diverse populations are necessary—and increasingly feasible—for detailed microbiome variation studies as well.

T2D affects approximately 537 million people worldwide. In T2D, the body gradually loses its ability to regulate blood sugar effectively. Research over the last decade has linked changes in the gut microbiome—the collection of bacteria, fungi, and viruses that inhabit our intestines—to the development of T2D. However, prior studies of the gut microbiome and its role in T2D have been too small and varied in study design to draw significant conclusions.

This study analyzed data from the newly established Microbiome and Cardiometabolic Disease Consortium (MicroCardio). The investigation included newly generated data and those originally captured during several other experiments, encompassing a total of 8,117 gut microbiome metagenomes from ethnically and geographically diverse participants.

People included in the study had T2D, prediabetes, or no changes in their blood sugar levels and hailed from several countries in the world. 

Part 1

Comment by Dr. Krishna Kumari Challa on June 26, 2024 at 7:00am

CSIR-NIIST Director Dr C. Anandharamakrishnan and Director, AIIMS, New Delhi, Dr M Srinivas, exchanged the MoU in the presence of Union Minister of State for Science & Technology and Vice President, CSIR, Dr. Jitendra Singh.

 

Secretary, DSIR and Director General, CSIR, Dr. N Kalaiselvi; and Director, CSIR-CBRI, Prof R. Pradeep Kumar, were also present. 

 

Speaking on the occasion, Dr. Jitendra Singh said scientists need to look into how all those resources which have remained unexplored are going to do the value addition to carry India to the top pedestal.  

 

“Scientific community need to explore Himalayan and marine resources and we have an opportunity to explore further the lesser explored. That is going to add value as we are already saturated,” Dr. Singh added. 

 

Dr. Kalaiselvi said OWOT is one platform wherein CSIR can showcase to the entire nation innovative ideas based on seven themes.

 

 “These ideas will help us win the confidence of stakeholders. We’ll showcase to the entire world that CSIR will be the ultimate technology provider and help the nation stay itself as a leading capital on global arena as far as technology transfer is concerned,” Dr. Kalaiselvi added.       

 

CSIR-NIIST Director Dr C. Anandharamakrishnan said CSIR-NIIST is actively working on various waste management strategies, including biomedical waste, and environmental wellbeing.

 

“Global sustainability is our prime concern at CSIR-NIIST. The technology that we developed for converting pathogenic biomedical waste into value-added soil additives is a perfect example for the ‘Waste to Wealth’ concept,” he said.

 

Dr Anandharamakrishnan said CSIR-NIIST is committed to delivering sustainability in every technology with societal, national and global significance. It also targets an innovative solution for the safe and eco-friendly management of pathogenic biomedical waste through the present technology.

 

Biomedical waste, which includes potentially infectious and pathogenic materials, presents a significant challenge for proper management and disposal. As per a 2020 report by the Central Pollution Control Board (CPCB), India produces around 774 tonnes of biomedical waste daily.

 

CSIR-NIIST has also developed an automated and integrated equipment to ensure minimal human exposure during any stage of pathogenic biomedical waste treatment. The equipment was displayed at a previous expo organized by CSIR at Bharat Mandapam in the national capital last year.

 

 

On the occasion, CSIR-NIIST also transferred the technology for manufacturing plant leather alternatives from agri waste (cactus) to startup Veganvista Corp Pvt Ltd., Ahmedabad. This technology assures reduction of carbon footprint and utilisation waste lands in arid and semi-arid regions for cactus cultivation and value addition to farmers in Rajasthan, Gujarat, and Maharashtra.

 

Besides, CSIR-NIIST’s technology for making plant oil sourced bio-resin for paper coating was also transferred to a startup owned by Sanchit Gulati and his team, Panipat, Haryana, at the event.

 

The process knowhow developed on bio-resin coating from plant oils can replace single use plastic liner on paper and other cellulosic products to design an eco-friendly, green and sustainable packaging material with biodegradability and re-pulpability potential.

Part 2

Comment by Dr. Krishna Kumari Challa on June 26, 2024 at 7:00am

CSIR-NIIST inks MoU with AIIMS for validating alternative tech for disposing biomedical waste

New Delhi, June 25: CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, has inked a Memorandum of Understanding (MoU) with All India Institute of Medical Sciences (AIIMS), New Delhi, for validating the technology that offers a sustainable and energy-efficient alternative to current practices in disposing pathogenic biomedical waste.

 

The MoU was signed on the sidelines of the curtain raiser of CSIR’s ‘One Week One Theme’ (OWOT) programme at India Habitat Centre, here yesterday.

 

CSIR-NIIST has developed a dual disinfection-solidification system that can spontaneously disinfect and immobilize degradable pathogenic biomedical waste such as blood, urine, saliva, sputum, and laboratory disposables, besides imparting a pleasant natural fragrance to otherwise foul-smelling biomedical waste. 

 

CSIR-NIIST, a constituent laboratory under the Council of Scientific and Industrial Research (CSIR), Ministry of Science and Technology, Govt. of India, has developed the technology at its laboratory at Pappanamcode in Thiruvananthapuram.

 

The technology has the potential for far-reaching consequences in the global biomedical arena, as it can address the limitations of conventional technologies, including energy-intense incineration. It will be validated via a pilot-scale installation and accompanying R&D at the AIIMS. The two institutions will have a technical meeting for finalizing the specifications prior to initiation of the proposed study.

 

The developed technology has also been confirmed by expert third-parties for its antimicrobial action and non-toxic nature of the treated material. Soil studies have confirmed that the treated biomedical waste is superior to organic fertilizers like vermicompost.

 Part 1

Comment by Dr. Krishna Kumari Challa on June 25, 2024 at 9:10am

India typically has two monsoons: one from June to September moving southwest to northeast, and another from October to December going the opposite direction.

But with more planet-warming gases in the air, the rain now only loosely follows this pattern. This is because the warmer air can hold more moisture from the Indian Ocean, and that rain then gets dumped all at once. It means the monsoon is punctuated with intense flooding and dry spells, rather than sustained rain throughout.

Landslides and flooding are increasing, alongside high temperatures and longer periods of drought that are adding to farmers' woes.

This  erratic rain is a significant blow to farmers' livelihood. Unless they adapt to this new uncertainty, the future looks bleak for them, unless science helps them.

Source: AP and other news agencies.

Part 2

Comment by Dr. Krishna Kumari Challa on June 25, 2024 at 9:07am

Climate change makes India's monsoons erratic

Each year from June to September, a heavy band of rain makes its way from India's southwest coast to its northeastern borders, quenching farmers' thirsty fields.

India's monsoon season is arguably the single most important weather phenomenon for the country, and a good monsoon can noticeably boost the nation's economy and the livelihoods of its 120 million farmers. But human-caused climate change is making the rainfall more erratic, making it difficult for farmers to plant, grow and harvest crops on their rain-fed fields.

Either it rains too much within a short time or it doesn't rain at all. 

The Indian Meteorological Department had predicted good rainfall from the monsoon clouds earlier this year, but extreme heat in northern India stalled the rain's progress. The agency revised its predictions in June, saying the rainfall this year will be less than previously expected.

Many are looking for ways to adapt to this new, unpredictable reality. Experts suggest growing crops that need less water, better and more localized forecasting methods and protection against unexpected weather. But changing centuries-old ways of tending to the land won't be an easy task.

Part 1

Comment by Dr. Krishna Kumari Challa on June 25, 2024 at 9:03am

New study confirms forever chemicals are absorbed through human skin

A study of 17 commonly-used synthetic 'forever chemicals' has shown that these toxic substances can readily be absorbed through human skin.

New research, published in Environment International proves for the first time that a wide range of PFAS (perfluoroalkyl substances)—chemicals which do not break down in nature—can permeate the skin barrier and reach the body's bloodstream.

PFAS are used widely in industries and consumer products from school uniforms to personal care products because of their water and stain repellent properties. While some substances have been banned by government regulation, others are still widely used and their toxic effects have not yet been fully investigated.

PFAS are already known to enter the body through other routes, for example being breathed in or ingested via food or drinking water, and they are known to cause adverse health effects such as a lowered immune response to vaccination, impaired liver function and decreased birth weight.

It has commonly been thought that PFAS are unable to breach the skin barrier, although recent studies have shown links between the use of personal care products and PFAS concentrations in human blood and breast milk. The new study is the most comprehensive assessment yet undertaken of the absorption of PFAS into human skin and confirms that most of them can enter the body via this route.

Oddný Ragnarsdóttir et al, Dermal bioavailability of perfluoroalkyl substances using in vitro 3D human skin equivalent models, Environment International (2024). DOI: 10.1016/j.envint.2024.108772

Comment by Dr. Krishna Kumari Challa on June 25, 2024 at 8:25am

Overall, the findings gathered by this research team suggest that changes in brain activity in the prefrontal cortex influence how one is perceived, particularly in terms of their physical attractiveness. Yet these changes were found to have no effect on how attractive the individuals with this change in activity perceive themselves to be, suggesting that internal perceptions are not a good indicator of how others perceive us.

Attraction is altered via modulation of the medial prefrontal cortex without explicit knowledge. Frontiers in Human Neuroscience(2024). DOI: 10.3389/fnhum.2024.1333733. www.frontiersin.org/journals/h … 024.1333733/abstract

Part 2

Comment by Dr. Krishna Kumari Challa on June 25, 2024 at 8:24am

Stimulating the medial prefrontal cortex changes a person's perceived attractiveness, study suggests

Humans typically perceive others and themselves as more or less physically attractive, yet the neural underpinnings of these attractiveness-related perceptions remain widely unexplored. While some past studies found that stimulating the brain, particularly the medial prefrontal cortex (MPFC), can change a person's physical appearance, they did not determine whether it altered how attractive they were perceived to be by others.

Researchers at Montclair State University recently tried to answer this research question, by conducting a two-phase experiment involving human participants. Their findings, published in Frontiers in Human Neuroscience, suggest that modulating activity in the MPFC using brain stimulation techniques changes how attractive one is perceived to be by others.

This research work  's aimed at answering two main research questions. The first was whether, after brain stimulation, a person would be perceived as more attractive. The second was whether they would themselves feel more attractive or confident in their appearance.

To do this, the researchers recruited a total of 440 participants, 10 of which took part in the first phase of their experiment and 430 of which in the second. In the first experimental phase, they stimulated the brain of 10 participants and then took a picture of them.

The researchers used five different conditions. They knew that the prefrontal cortex (the frontal part of the human brain) was the area of interest. So they sped up activity there (excitation). They also slowed activity there (inhibition). They then compared these two conditions with some controls.

They  found that people did not feel more attractive or more confident after their brain was stimulated. In other words, after receiving brain stimulation, participants reported feeling exactly the same about themselves as they did before the experiment.

During the second phase of the experiment, the researchers asked 430 new individuals to rate the pictures they had taken of the first 10 initial candidates, following brain stimulation. Remarkably, they found that the inhibition of the frontal cortex made people more attractive, while exciting it made them less attractive. In other words, people whose frontal cortex was inhibited using brain stimulation were rated as more attractive by others than those whose frontal cortex had been excited (i.e., speeding up activity of neurons in the region).

This is the first time that brain stimulation has been found to change attractiveness. Furthermore, this is one of the first, if not the first study that has had a large sample of people rate on any measure of a person following brain stimulation. Third, people become more attractive without experiencing any conscious change themselves. The changes in one's appearance took place in an unconscious manner

Part 1

Comment by Dr. Krishna Kumari Challa on June 22, 2024 at 12:18pm

How a microbe and a prebiotic work together against food allergies

What causes food allergies to develop? There's compelling evidence that suggests imbalances of the gut microbiome could be to blame, creating inflammation of the intestinal tract and a gut environment that's prone to food allergies.

Now, new research reveals a mutually beneficial relationship between an unassuming microbial species and the prebiotic lactulose—together, they encourage the production of an important metabolite known for its positive influence on gut health, butyrate, that's generated as bacteria feed in the gut.

Butyrate is a four-carbon molecule that has huge effects in the gut… this could have broad impacts for food allergies because it could pave the way to development of a synbiotic therapeutic that "addresses dysbiosis of the microbiome, rather than treating the response to an individual allergen."

In a paper published in Cell Host and Microbe,  researchers report that treatment with a concoction of A. caccae and the prebiotic lactulose increased butyrate levels in the intestinal tracts of mice, stifling allergic responses to cow's milk.

Lauren A. Hesser et al, A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice, Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.05.019

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