Comment

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 10:15am

A PFO is usually harmless yet is known to increase the odds of stroke. The study aimed to determine which risk factors contribute the most to unexplained strokes.

The analysis found:

Traditional risk factors were more strongly associated with stroke in men and women without a PFO.
In contrast, nontraditional risk factors, such as blood clots in the veins, migraine with aura, chronic kidney disease, chronic liver disease or cancer, were more strongly associated with stroke among study participants with a PFO.
In those without a PFO, each additional traditional risk factor increased stroke risk by 41%, while each nontraditional risk factor increased stroke risk by 70%.
Risk factors related to women also increased stroke risk by 70% independent of traditional and nontraditional risk factors.
Among participants with a PFO, each traditional risk factor increased the risk of stroke by 18%. However, after considering individual demographic factors, such as age, sex and level of education, nontraditional risk factors more than doubled the odds of having an ischemic stroke.
Researchers also analyzed the study population's attributable risk (determining how a disease would be impacted if a certain risk factor were eliminated). To calculate population-attributable risk, researchers analyzed each risk factor and their contribution to the increased risk separately and found:

For strokes that occur without a PFO, traditional risk factors accounted for about 65% of the cases, nontraditional risk factors contributed 27% and risk factors specific to women made up nearly 19% of the cases.
In contrast, for strokes associated with a PFO, traditional risk factors contributed about 34%, nontraditional risk factors accounted for 49% and female-specific risk factors represented about 22%.
Notably, migraine with aura was the leading nontraditional risk factor associated with strokes of unknown origin, with a population-attributable risk of about 46% for strokes among people with a PFO and about 23% for those without a PFO, indicating a higher risk for people with PFO.
The role of non-traditional risk factors, especially migraine headaches, which seems to be one of the leading risk factors in the development of strokes in younger adults, is a new revelation.

Burden of Modifiable Risk Factors in YoungOnset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale, Stroke (2025). DOI: 10.1161/STROKEAHA.124.049855

Part 2

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 10:13am

Nontraditional risk factors shed light on unexplained strokes in adults younger than 50

Adults younger than 50 years of age had more than double the risk of having a stroke from migraine or other nontraditional stroke risk factors rather than traditional risks such as high blood pressure, according to research published in Stroke.

Previous research indicates the rate of ischemic (clot-caused) stroke among adults 18–49 years old is increasing and propelled by a corresponding rise in cryptogenic strokes (strokes of unknown cause) in adults without traditional risk factors, including high blood pressure, smoking, obesity, high cholesterol and type 2 diabetes.

Up to half of all ischemic strokes in younger adults are of unknown causes, and they are more common in women. For effective prevention, careful and routine assessment of both traditional and nontraditional risk factors in younger people is critical. 

Researchers analyzed data for more than 1,000 adults aged 18–49 in Europe, with a median age of 41 years. Half of the participants had experienced a cryptogenic ischemic stroke, while half had no history of stroke.

The study examined the associations of 12 traditional risk factors, 10 nontraditional risk factors and five risk factors specific to women (such as gestational diabetes or pregnancy complications). Researchers also closely reviewed participants with a heart defect called patent foramen ovale (PFO), a hole between the heart's upper chambers.

Part 1

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 9:49am

How cleft lip and cleft palate can arise

Cleft lip and cleft palate are among the most common birth defects.

These defects, which appear when the tissues that form the lip or the roof of the mouth do not join completely, are thought to be caused by a mix of genetic and environmental factors.

In a new study,  biologists have discovered how a genetic variant often found in people with these facial malformations leads to the development of cleft lip and cleft palate.

Their findings suggest that the variant diminishes cells' supply of transfer RNA, a molecule that is critical for assembling proteins. When this happens, embryonic face cells are unable to fuse to form the lip and roof of the mouth.

A non-syndromic orofacial cleft risk locus links tRNA splicing defects to neural crest cell pathologies, The American Journal of Human Genetics (2025). DOI: 10.1016/j.ajhg.2025.03.017. www.cell.com/ajhg/fulltext/S0002-9297(25)00138-7

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 9:42am

Scientists hack cell entry to supercharge cancer drugs

A new discovery could pave the way for more effective cancer treatment by helping certain drugs work better inside the body. Scientists have found a way to improve the uptake of a promising class of cancer-fighting drugs called PROTACs, which have struggled to enter cells due to their large size.

The new method works by taking advantage of a protein called CD36 that helps pull substances into cells. By designing drugs to use this CD36 pathway, researchers delivered 7.7 to 22.3 times more of the drug inside cancer cells, making the treatment up to 23 times more potent than before, according to the study published April 17 in Cell.

Data from mouse studies shows this enhanced uptake led to stronger tumor suppression without making the drugs harder to dissolve or less stable.

The strategy called chemical endocytic medicinal chemistry (CEMC) takes advantage of a natural process where cells "swallow" molecules called endocytosis. It could change the future of drug design—especially for drugs that were once considered too big to work.

CD36-mediated endocytosis of proteolysis-targeting chimeras, Cell (2025). DOI: 10.1016/j.cell.2025.03.036. www.cell.com/cell/fulltext/S0092-8674(25)00386-1

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:58am

With a comprehensive dataset and in-depth profiling of Gowanus microbial communities, researchers were able to identify previously undocumented microbial lineages and assess their potential for environmental remediation.

Metagenomic analysis of sediment samples from the Gowanus Canal revealed a diverse microbial community comprising 455 distinct microbial species, including bacteria, archaea, and viruses.

Across both surface and core samples, researchers identified 64 metabolic pathways involved in the degradation of organic contaminants, alongside 1,171 genes associated with the detoxification of heavy metals such as iron, copper, and nickel. Researchers identified 2,319 biosynthetic gene clusters, many of which may be linked to the production of novel secondary metabolites with potential therapeutic or industrial value.
A comprehensive screening of antimicrobial resistance genes demonstrated the presence of 28 resistance genes across eight different antibiotic classes, including agents commonly used in clinical settings such as rifampin and aminoglycosides.

Coexistence of pollutant-degrading genes and antimicrobial resistance likely arises from ecological adaptations driven by prolonged exposure to urban and industrial waste. Microorganisms within the canal deploy multiple degradation pathways to metabolize pollutants like toluene and phenolic compounds, while simultaneously exhibiting traits that confer resilience to heavy metal stress.
Findings suggest that extreme urban ecosystems like the Gowanus Canal may act as reservoirs of both beneficial and hazardous genetic elements. Some of the antimicrobial resistance genes appear to originate from human gut-associated microbes, likely introduced through untreated sewage overflow, raising urgent new concerns around public health risks.

While not an experiment any scientist would have chosen to run, if future research findings lead to novel industrial or clinical insights, it could transform the Gowanus Canal from a symbol of urban neglect into that of a living laboratory. One where the pressures of prolonged contamination have forged a microbial community that has created the keys to future ecological restoration and molecular innovation.

Sergios-Orestis Kolokotronis et al, Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential, Journal of Applied Microbiology (2025). DOI: 10.1093/jambio/lxaf076

Part 2

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:55am

Extreme microbial adaptations arise in one of  most polluted waterways

The industrially ravaged Gowanus Canal, long regarded as a symbol of urban environmental neglect, is being reimagined through the lens of scientific inquiry as a complex reservoir of microbial life shaped by intense selective pressures.

Research  has discovered microbes in Brooklyn's Gowanus Canal that carry genes for breaking down industrial pollutants and neutralizing heavy metals. Genetic screening also uncovered resistance to multiple antibiotic classes and thousands of biosynthetic gene clusters with implications for developing new antibiotics, industrial enzymes, and bioactive compounds.

Built in the mid 1800s, the 2.9 km long industrial canal has experienced over 150 years of unregulated environmental abuse. As a hub of heavy industry, various mills, petroleum and chemical plants have lined the canal banks.

Unknown volumes of arsenic, heavy metals, polychlorinated biphenyls, coal tar, petroleum products, volatile organic compounds, chlorinated solvents and untreated sewage overflow have discharged into the small waterway.

Designated a Superfund site in 2010, the Gowanus Canal is one of the most contaminated waterways in the United States. When the EPA began evaluating the site for restoration, they discovered approximately two hundred previously unknown and unpermitted pipes that discharge directly into the canal.

So toxic are the sediments and extreme the environment that mere skin contact with the water poses a health hazard for humans. To microbiologists, such extreme environments are highly intriguing opportunities to see how life finds a way to adapt and even thrive. Microbial life has previously been discovered in similarly extreme contexts.

Discoveries in NASA clean rooms revealed microbes that lived off of paint and cleaning solutions. An enzyme that revolutionized early genomic research came from a bacterium found in the hot springs of Yellowstone National Park. Microorganisms discovered in contaminated environments have previously been used to degrade petroleum hydrocarbons and other pollutants.

While the Gowanus Canal is unquestionably an environmental disaster, it can also serve as a long-running experiment in microbial evolution.

In the study, "Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential," published in the Journal of Applied Microbiology, researchers performed a metagenomic analysis of microbial communities in the Gowanus Canal.

Part 1

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:46am

The absorption of some of the starlight in the planet's atmosphere leaves imprints in the stellar spectrum that astronomers can piece together to determine the constituent gases of the exoplanet's atmosphere.

The earlier, tentative, inference of DMS was made using JWST's NIRISS (Near-Infrared Imager and Slitless Spectrograph) and NIRSpec (Near-Infrared Spectrograph) instruments, which together cover the near-infrared (0.8-5 micron) range of wavelengths. The new, independent observation used JWST's MIRI (Mid-Infrared Instrument) in the mid-infrared (6-12 micron) range.
This is an independent line of evidence, using a different instrument than the scientists did before and a different wavelength range of light, where there is no overlap with the previous observations. "The signal came through strong and clear."
It 's an incredible realization seeing the results emerge and remain consistent throughout the extensive independent analyses and robustness tests.
DMS and DMDS are molecules from the same chemical family, and both are predicted to be biosignatures. Both molecules have overlapping spectral features in the observed wavelength range, although further observations will help differentiate between the two molecules.
However, the concentrations of DMS and DMDS in K2-18b's atmosphere are very different than on Earth, where they are generally below one part per billion by volume. On K2-18b, they are estimated to be thousands of times stronger—over ten parts per million.
Earlier theoretical work had predicted that high levels of sulfur-based gases like DMS and DMDS are possible on Hycean worlds (covered in oceans). Given everything we know about this planet, a Hycean world with an ocean that is teeming with life is the scenario that best fits the data we have, say the scientists.
While the results are exciting, it's vital to obtain more data before claiming that life has been found on another world. While scientists are cautiously optimistic, there could be previously unknown chemical processes at work on K2-18b that may account for the observations.
Scientists have to conduct further theoretical and experimental work to determine whether DMS and DMDS can be produced non-biologically at the level currently inferred.
The inference of these biosignature molecules poses profound questions concerning the processes that might be producing them.
It's important that we're deeply skeptical of our own results, because it's only by testing and testing again that we will be able to reach the point where we're confident in them,"  the scientists add. "That's how science has to work."

Nikku Madhusudhan et al, New Constraints on DMS and DMDS in the Atmosphere of K2-18 b from JWST MIRI, The Astrophysical Journal Letters (2025). DOI: 10.3847/2041-8213/adc1c8

Part 2

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:38am

Astronomers detect strongest sign yet of possible life on a planet beyond our own

Astronomers have detected the most promising signs yet of a possible biosignature outside the solar system, although they remain cautious.

Using data from the James Webb Space Telescope (JWST), the astronomers have detected the chemical fingerprints of dimethyl sulfide (DMS) and/or dimethyl disulfide (DMDS), in the atmosphere of the exoplanet K2-18b, which orbits its star in the habitable zone.

On Earth, DMS and DMDS are only produced by life, primarily microbial life such as marine phytoplankton. While an unknown chemical process may be the source of these molecules in K2-18b's atmosphere, the results are the strongest evidence yet that life may exist on a planet outside our solar system.

The observations have reached the 'three-sigma' level of statistical significance—meaning there is a 0.3% probability that they occurred by chance. To reach the accepted classification for scientific discovery, the observations would have to cross the five-sigma threshold, meaning there would be below a 0.00006% probability they occurred by chance.

The researchers say between 16 and 24 hours of follow-up observation time with JWST may help them reach the all-important five-sigma significance. Their results are reported in The Astrophysical Journal Letters.

Earlier observations of K2-18b—which is 8.6 times as massive and 2.6 times as large as Earth, and lies 124 light years away in the constellation of Leo—identified methane and carbon dioxide in its atmosphere. This was the first time that carbon-based molecules were discovered in the atmosphere of an exoplanet in the habitable zone.

Those results were consistent with predictions for a 'Hycean' planet: a habitable ocean-covered world underneath a hydrogen-rich atmosphere.

However, another, weaker signal hinted at the possibility of something else happening on K2-18b. Scientists didn't know for sure whether the signal they saw last time was due to DMS, but just the hint of it was exciting enough for them to have another look with JWST using a different instrument.

To determine the chemical composition of the atmospheres of faraway planets, astronomers analyze the light from its parent star as the planet transits, or passes in front of the star as seen from Earth. As K2-18b transits, JWST can detect a drop in stellar brightness, and a tiny fraction of starlight passes through the planet's atmosphere before reaching Earth.

Part 1

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:23am

The discovery of carbonate suggests that the atmosphere contained enough carbon dioxide to support liquid water existing on the planet's surface. As the atmosphere thinned, the carbon dioxide transformed into rock form.
NASA says future missions and analysis of other sulfate-rich areas on Mars could confirm the findings and help to better understand the planet's early history and how it transformed as its atmosphere was lost.
Scientists are trying to determine whether Mars was ever capable of supporting life—and the latest paper brings them closer to an answer. It tells us that the planet was habitable and that the models for habitability are correct.
The broader implications are the planet was habitable up until this time, but then, as the CO2 that had been warming the planet started to precipitate as siderite, it likely impacted Mars' ability to stay warm.

"The question looking forward is how much of this CO2 from the atmosphere was actually sequestered? Was that potentially a reason we began to lose habitability?"
The latest research fits with his ongoing work on Earth—trying to turn anthropogenic CO2 into carbonates as a climate change solution.

Learning about the mechanisms of making these minerals on Mars helps us to better understand how we can do it here.
Studying the collapse of Mars' warm and wet early days also tells us that habitability is a very fragile thing. It's clear that small changes in atmospheric CO2 can lead to huge changes in the ability of the planet to harbour life.
The most remarkable thing about Earth is that it's habitable and it has been for at least four billion years. Something happened to Mars that didn't happen to Earth.
What is it and how can we avoid such a situation, if we ever can, here on Earth?

We must catch these answers that are blowing in the thin Martian atmosphere and embedded in the dust on the planet's surface.

Benjamin M. Tutolo, Carbonates identified by the Curiosity rover indicate a carbon cycle operated on ancient Mars, Science (2025). DOI: 10.1126/science.ado9966. www.science.org/doi/10.1126/science.ado9966

Part 2

Comment by Dr. Krishna Kumari Challa on April 18, 2025 at 8:16am

Curiosity rover finds large carbon deposits on Mars

And scientists are trying to answer some of the questions on earlier Martian life and that of the Earth at present with these findings

Research from NASA's Curiosity rover has found evidence of a carbon cycle on ancient Mars, bringing scientists closer to an answer on whether the red planet was ever capable of supporting life.

The team is working to understand climate transitions and habitability on ancient Mars as Curiosity explores Gale Crater.

The paper, published in the journal Science, reveals that data from three of Curiosity's drill sites had siderite, an iron carbonate material, within sulfate-rich layers of Mount Sharp in Gale Crater.

The discovery of large carbon deposits in Gale Crater represents both a surprising and important breakthrough in our understanding of the geologic and atmospheric evolution of Mars. 

The abundance of highly soluble salts in these rocks and similar deposits mapped over much of Mars has been used as evidence of the 'great drying' of Mars during its dramatic shift from a warm and wet early Mars to its current, cold and dry state.

Sedimentary carbonate has long been predicted to have formed under the CO₂-rich ancient Martian atmosphere. 

NASA's Curiosity rover landed on Mars on Aug. 5, 2012, and has traveled more than 34 kilometers on the Martian surface.

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