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Comment by Dr. Krishna Kumari Challa yesterday

Scientists develop technique to identify malfunctions in our genetic code
An international team of researchers have developed a way to reveal the smallest of malfunctions in the biochemical machinery that makes proteins in our bodies. According to the researchers, these malfunctions, however small, can trigger neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as cancer and developmental disorders.

A new technique enables real-time detection of structural malfunctions in individual tRNA molecules by analyzing them as they pass through nanopores in a silicon membrane. Mutations in tRNA can cause abnormal shapes, disrupting protein synthesis and contributing to diseases such as neurodegeneration and cancer. This approach may facilitate early diagnosis and drug screening targeting tRNA stability.
The technique, which works by squeezing molecules through tiny holes in a silicon-based membrane, helps scientists understand how a mutation in a transfer RNA (tRNA) molecule—tRNA is a molecular messenger essential for building proteins—affects the molecule's real-time structure.

Shankar Dutt et al, Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNA^Arg, Nucleic Acids Research (2026). DOI: 10.1093/nar/gkaf1411

Comment by Dr. Krishna Kumari Challa yesterday

Unseen world: Cuttlefish use polarized light to create a dramatic mating display invisible to humans

Many organisms leverage showy colors for attracting mates. Because color is a property of light (determined by its wavelength), it is easy for humans to see how these colors are used in animal courting rituals. Less obvious to humans is the polarization of light—a property of light related to the direction the wave is oriented in. Humans can't perceive polarization, which may be why we weren't aware of the interesting way cuttlefish use it to attract mates.

A new study, published in the Proceedings of the National Academy of Sciences, takes a closer look at the way male cuttlefish put on a show by polarizing light waves with their arms during courtship.

Unlike humans, cephalopods, like cuttlefish, have the ability to perceive the polarization of light. If some light waves are oriented vertically and others are oriented horizontally, cuttlefish differentiate these in a similar way that humans might differentiate blue and red light. On the other hand, cuttlefish don't have the ability to perceive color. Instead, cephalopods can use their polarization vision to aid in functions such as navigation, target detection, or visual noise reduction.

Prior studies have also found that the bodies of some species can reflect strongly polarized light, which could potentially be used as a signal or means of communication. This idea made some researchers curious about the role of polarization in sexual signaling among those species lacking color vision.

The study focuses on the Andrea cuttlefish (Doratosepion andreanum). When trying to attract a mate, the male Andrea cuttlefish extends its two sexually dimorphic arms (SDAs), which are around three times longer than the equivalent arms of female Andrea cuttlefish. He also extends his body and turns a pale color. However, observing this ritual with a specialized camera for analyzing polarization patterns, revealed that there was more to this dance than what humans could see.

The camera showed that male cuttlefish also displayed a unique courtship signal using vertically and horizontally polarized light on their specialized arms. When the team observed the cuttlefish outside of the courtship ritual, only horizontally polarized light was seen, matching the pattern on female cuttlefish. Further analysis showed that these horizontally and vertically polarized light patterns would appear highly conspicuous to cuttlefish polarization vision, maximizing contrast for potential mates.

Arata Nakayama et al, Transmission through muscle tissue shapes polarization signals during cuttlefish courtship, Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2517167123

Comment by Dr. Krishna Kumari Challa yesterday

The many faces of monster galaxies

Observations of three early universe "monster galaxies" reveal diverse growth mechanisms, including major mergers, internal gravitational instabilities, and minor interactions. High-resolution data from ALMA and JWST show that rapid star formation in these galaxies does not follow a single pathway, indicating multiple evolutionary routes for the ancestors of today’s giant ellipticals.

Ryota Ikeda et al, Formation of Substructure in Luminous Submillimeter Galaxies (FOSSILS): Evidence of Multiple Pathways to Trigger Starbursts in Luminous Submillimeter Galaxies, The Astrophysical Journal (2026). DOI: 10.3847/1538-4357/ae157e

Comment by Dr. Krishna Kumari Challa yesterday

Milky Way is embedded in a 'large-scale sheet' of dark matter, which explains motions of nearby galaxies
Simulations indicate that the Milky Way and Andromeda are embedded in a large-scale, flat sheet of dark matter, with voids above and below. This structure explains the observed motions and distribution of nearby galaxies, aligning with the Hubble-Lemaître law and resolving longstanding discrepancies in local galactic dynamics.

Ewoud Wempe et al, The mass distribution in and around the Local Group, Nature Astronomy (2026). DOI: 10.1038/s41550-025-02770-w. www.nature.com/articles/s41550-025-02770-w

Comment by Dr. Krishna Kumari Challa yesterday

AI unlocks hundreds of cosmic anomalies in Hubble archive

An AI-based tool analyzed nearly 100 million Hubble Space Telescope images, identifying over 1,300 rare cosmic anomalies, including galaxy mergers, gravitational lenses, and previously unclassified objects. More than 800 of these had not been documented before. This approach demonstrates AI's effectiveness in rapidly detecting unusual phenomena within vast astronomical datasets.

David O'Ryan et al, Identifying astrophysical anomalies in 99.6 million source cutouts from the Hubble legacy archive using AnomalyMatch, Astronomy & Astrophysics (2025). DOI: 10.1051/0004-6361/202555512

Comment by Dr. Krishna Kumari Challa yesterday

 Brain scans reveal the cerebellum's crucial role in human language

Even though the cerebellum makes up only about 10% of the brain's size, it carries an outsized load, containing nearly 80% of all the brain's neurons.

For a long time, its function was mainly linked to movement and coordination, but years of research has made it evident that the little brain isn't a one-trick pony. It plays an important role in human thinking, including language, and may have even helped make abilities like language possible over the course of evolution.

The cerebellum, often called the little brain, plays a much bigger role in language processing than once thought. Located at the base of the brain, the cerebellum has long been thought to be mainly responsible for motor response, balance, and basic coordination.

A recent large-scale study analyzing brain scans from over 900 participants revealed a surprising new specialization within this region.

Four specific regions in the cerebellum are closely connected to the brain's main language network, constantly communicating with it to help process human language. What was especially surprising is that one of these regions, called LangCereb3, appears to be a true language specialist, responding almost exclusively to language processing rather than to other kinds of mental tasks.

The researchers think that since  LangCereb3  works closely with the brain's main language center, it can be used as the target when treating patients with loss of ability to understand or express speech due to stroke or language disorders like aphasia.

Colton Casto et al, The cerebellar components of the human language network, Neuron (2026). DOI: 10.1016/j.neuron.2025.12.030

Comment by Dr. Krishna Kumari Challa yesterday

In their analyses, the researchers looked at both yes/no responses and more detailed explanations provided by participants. This allowed them to gain insight into how people reasoned about deepfake videos that are "flagged" as AI-generated.

Many participants continued to engage with the video itself rather than simply deferring to the warning, which helps explain why transparency reduces influence without fully neutralizing it. This has clear implications for regulation, where disclosure is often treated as a sufficient safeguard.

Simon Clark et al, The continued influence of AI-generated deepfake videos despite transparency warnings, Communications Psychology (2026). DOI: 10.1038/s44271-025-00381-9

Part 2

Comment by Dr. Krishna Kumari Challa yesterday

People are swayed by AI-generated videos even when they know they're fake!

Generative deep learning models are artificial intelligence (AI) systems that can create texts, images, audio files, and videos for specific purposes, following instructions provided by human users. Over the past few years, the content generated by these models has become increasingly realistic and is often difficult to distinguish from real content.

Many of the videos and images circulating on social media platforms today are created by generative deep learning models.

 Some computer scientists have proposed strategies to mitigate the possible adverse effects of fake content diffusion, such as clearly labelling these videos as AI-generated.

Researchers recently carried out a new study set out to better understand the influence of deepfake videos on viewers, while also assessing user perceptions when AI-generated videos are labeled as "fake." Their findings, published in Communications Psychology, suggest that knowing that a video was created with AI does not always make it less "persuasive" for viewers.

Some past psychological studies suggest that people can be influenced by information they are presented with even if they know it to be false, unreliable, or irrelevant. The researchers wondered whether this pattern also applies to the deep fake videos that people watch online.

What happens when people encounter a deepfake video that has already been identified and clearly flagged as fake?

To assess people's perceptions of "flagged" deepfake videos, the researchers carried out three online experiments involving 175, 275, and 223 participants, respectively. The participants were asked to watch short videos that showed a person admitting that they had committed a crime or a moral transgression.

Crucially, in some conditions, participants were shown a warning before watching the video, stating that it had been identified and flagged as a deepfake, while other participants saw no warning, or a generic warning about the existence of deepfakes. They also added a control condition, in which participants watched a version of the video with all relevant information obscured by background sounds.

After watching each of the videos, participants were asked a series of simple questions. They were asked whether they thought the video was fake and if they believed the person was guilty of a crime or moral transgression.

When they analyzed the participants' responses, the researchers found that most participants were still influenced by the content of a video, even if they were warned that it was fake and generated with AI. Interestingly, many participants acknowledged that a video was fake but still judged the person in the video as guilty of the crime or transgression that they confessed to.

Warnings do reduce the effect, but they do not eliminate it, even among participants who say they believe the warning and know the video is a deepfake.

They also showed that different types of warnings have different effects. Specific warnings referring to a particular video are more effective at convincing people that a video is fake, whereas generic warnings do not reliably do so. At the same time, generic warnings can still alter how people interpret a video's content, which has implications for how such warnings are used.

Part 1

Comment by Dr. Krishna Kumari Challa on Tuesday

Fish allergy risk varies by fish size and which part is eaten, research reveals

Fish allergies vary by region and may affect up to 3% of the population.

A new study reveals allergy risks from fish depend not just on species but also on the size of the fish and which part you eat.

With increasing frequency, the consumption of fish or fish products triggers severe allergic reactions. This form of allergy is associated with a higher probability of life-threatening anaphylactic shock than many other food allergies. Even skin contact with fish or accidentally inhaling fish fumes can trigger an allergic reaction.

If you have an allergy, your immune system overreacts by producing allergen-specific IgE antibodies in your blood. Those antibodies sit on certain cells, which when exposed to fish proteins release substances, causing an allergic reaction.

He said while more than 1,000 different fish species are consumed globally, knowledge about species–specific and fish-specific allergenicity remains limited. 

Research Results showed protein profiles varied markedly by fish size and muscle region, but not between farmed or wild-caught fish. Smaller fish contained higher amounts of the major allergens parvalbumin and creatine kinase, while larger specimens had elevated levels of heat-labile allergens.

Allergen distribution also differed across body regions, suggesting that various cuts of the same fish may pose different risks for allergic consumers. For example, the head region contained more than twice the amount of the major fish allergen compared to the tail.

However, differences linked to production origin—e.g., whether the fish were wild-caught or farmed—were minimal, affecting only two of the 11 registered fish allergens.

 Fish allergy is highly complex and many people allergic to fish react to multiple allergens, so the scientists could not recommend eating smaller or larger fish as a safer option.

Thimo Ruethers et al, Fish size matters – Variable food allergen profiles in farmed and wild Malabar red snapper (Lutjanus malabaricus), Food Chemistry (2026). DOI: 10.1016/j.foodchem.2026.147950

Comment by Dr. Krishna Kumari Challa on Tuesday

Eye-surgery laser could be adapted for other organs, say scientists

Deep-ultraviolet, ultrashort-pulsed lasers, similar to those used in eye surgery, can remove soft tissue with axial precision of about 10 micrometers and minimal collateral damage. This technique could enable far greater accuracy than current neurosurgical tools, potentially transforming tumor removal and other delicate procedures in soft organs.

Tatiana K. Malikova et al, Deep ultraviolet ultrashort laser pulses for precise ablation of soft biological tissue, Biomedical Optics Express (2025). DOI: 10.1364/boe.578629

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