Science, Art, Litt, Science based Art & Science Communication
JAI VIGNAN
All about Science - to remove misconceptions and encourage scientific temper
Communicating science to the common people
'To make them see the world differently through the beautiful lense of science'
Members: 22
Latest Activity: 16 hours ago
WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING
THIS IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS
“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”
"Being a scientist is a state of mind, not a profession!"
"Science, when it's done right, can yield amazing things".
The Reach of Scientific Research From Labs to Laymen
The aim of science is not only to open a door to infinite knowledge and wisdom but to set a limit to infinite error.
"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.
Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.
If you are scientifically literate the world looks very different to you.
We do science and science communication not because they are easy but because they are difficult!
“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"
Links to some important articles :
1. Interactive science series...
a. how-to-do-research-and-write-research-papers-part 13
b. Some Qs people asked me on science and my replies to them...
Part 6, part-10, part-11, part-12, part 14 , part- 8,
part- 1, part-2, part-4, part-5, part-16, part-17, part-18 , part-19 , part-20
part-21 , part-22, part-23, part-24, part-25, part-26, part-27 , part-28
part-29, part-30, part-31, part-32, part-33, part-34, part-35, part-36, part-37,
part-38, part-40, part-41, part-42, part-43, part-44, part-45, part-46, part-47
Part 48, part49, Critical thinking -part 50 , part -51, part-52, part-53
part-54, part-55, part-57, part-58, part-59, part-60, part-61, part-62, part-63
part 64, part-65, part-66, part-67, part-68, part 69, part-70 part-71, part-73 ...
.......306
BP variations during pregnancy part-72
who is responsible for the gender of their children - a man or a woman -part-56
c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7
d. science-s-rules-are-unyielding-they-will-not-be-bent-for-anybody-part-3-
e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9
f. why astrology is pseudo-science part 15
g. How Science is demolishing patriarchal ideas - part-39
2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes
3. Science communication series:
a. science-communication - part 1
b. how-scienitsts-should-communicate-with-laymen - part 2
c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3
d. the-importance-of-science-communication-through-art- part 4
e. why-science-communication-is-geting worse - part 5
f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6
g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7
h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8
i. science-writers-and-communicators-where-are-you - part 9
j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10
k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11
l. golden-rules-of-science-communication- Part 12
m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13
n. an-informed-patient-is-the-most-cooperative-one -part 14
o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15
p. the-most-difficult-part-of-science-communication - part 16
q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17
r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18
s. is-post-truth-another-name-for-science-communication-failure?
t. why-is-it-difficult-for-scientists-to-have-high-eqs
u. art-and-literature-as-effective-aids-in-science-communication-and teaching
v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them
** qs-people-asked-me-on-science-and-my-replies-to-them-part-173
w. why-motivated-perception-influences-your-understanding-of-science
x. science-communication-in-uncertain-times
y. sci-com: why-keep-a-dog-and-bark-yourself
z. How to deal with sci com dilemmas?
A+. sci-com-what-makes-a-story-news-worthy-in-science
B+. is-a-perfect-language-important-in-writing-science-stories
C+. sci-com-how-much-entertainment-is-too-much-while-communicating-sc
D+. sci-com-why-can-t-everybody-understand-science-in-the-same-way
E+. how-to-successfully-negotiate-the-science-communication-maze
4. Health related topics:
a. why-antibiotic-resistance-is-increasing-and-how-scientists-are-tr
b. what-might-happen-when-you-take-lots-of-medicines
c. know-your-cesarean-facts-ladies
d. right-facts-about-menstruation
e. answer-to-the-question-why-on-big-c
f. how-scientists-are-identifying-new-preventive-measures-and-cures-
g. what-if-little-creatures-high-jack-your-brain-and-try-to-control-
h. who-knows-better?
k. can-rust-from-old-drinking-water-pipes-cause-health-problems
l. pvc-and-cpvc-pipes-should-not-be-used-for-drinking-water-supply
m. melioidosis
o. desensitization-and-transplant-success-story
p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!
q. swine-flu-the-difficlulties-we-still-face-while-tackling-the-outb
r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine
s. don-t-ignore-these-head-injuries
u. allergic- agony-caused-by-caterpillars-and-moths
General science:
a.why-do-water-bodies-suddenly-change-colour
b. don-t-knock-down-your-own-life-line
c. the-most-menacing-animal-in-the-world
d. how-exo-planets-are-detected
e. the-importance-of-earth-s-magnetic-field
f. saving-tigers-from-extinction-is-still-a-travail
g. the-importance-of-snakes-in-our-eco-systems
h. understanding-reverse-osmosis
i. the-importance-of-microbiomes
j. crispr-cas9-gene-editing-technique-a-boon-to-fixing-defective-gen
k. biomimicry-a-solution-to-some-of-our-problems
5. the-dilemmas-scientists-face
6. why-we-get-contradictory-reports-in-science
7. be-alert-pseudo-science-and-anti-science-are-on-prowl
8. science-will-answer-your-questions-and-solve-your-problems
9. how-science-debunks-baseless-beliefs
10. climate-science-and-its-relevance
11. the-road-to-a-healthy-life
12. relative-truth-about-gm-crops-and-foods
13. intuition-based-work-is-bad-science
14. how-science-explains-near-death-experiences
15. just-studies-are-different-from-thorough-scientific-research
16. lab-scientists-versus-internet-scientists
17. can-you-challenge-science?
18. the-myth-of-ritual-working
19.science-and-superstitions-how-rational-thinking-can-make-you-work-better
20. comets-are-not-harmful-or-bad-omens-so-enjoy-the-clestial-shows
21. explanation-of-mysterious-lights-during-earthquakes
22. science-can-tell-what-constitutes-the-beauty-of-a-rose
23. what-lessons-can-science-learn-from-tragedies-like-these
24. the-specific-traits-of-a-scientific-mind
25. science-and-the-paranormal
26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?
27. how-the-brain-of-a-polymath-copes-with-all-the-things-it-does
28. how-to-make-scientific-research-in-india-a-success-story
29. getting-rid-of-plastic-the-natural-way
30. why-some-interesting-things-happen-in-nature
31. real-life-stories-that-proves-how-science-helps-you
32. Science and trust series:
a. how-to-trust-science-stories-a-guide-for-common-man
b. trust-in-science-what-makes-people-waver
c. standing-up-for-science-showing-reasons-why-science-should-be-trusted
You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum
( Please go through the comments section below to find scientific research reports posted on a daily basis and watch videos based on science)
Get interactive...
Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.
Our mail ID: kkartlabin@gmail.com
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 16 hours ago. 3 Replies 0 Likes
Interactive science seriesQ: What are the disadvantages of doing DIRECT Ph.D.? Krishna: If you have the confidence to do a direct…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 18 hours ago. 1 Reply 0 Likes
Have you ever gone to the optometrist for an eye test and were told your eye was shaped like a football?Or perhaps you've noticed your vision is becoming increasingly blurry or hard to focus?You…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 1 Reply 0 Likes
Blindness, pneumonia, severe diarrhea and even death—measles virus infections, especially in children, can have devastating consequences. Fortunately, we have a safe and effective defense. Measles…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 19 Replies 2 Likes
What might happen when you take lots of medicines...One of our uncles died of liver cirrhosis ten years back. He never touched alcohol in his life. He didn't have any viral infection to cause this.…Continue
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If you are not getting enough sleep, your vascular cells may be drowning in oxidants!
Several people in the world are in the same situation of sleep deprivation and habitually get only five to six hours of sleep instead of the recommended seven to eight hours.
But even a mild chronic sleep deficit may heighten the risk of developing heart disease later in life: Surveys of thousands of people have found that people who report mild but chronic sleep deficits have more heart disease later in life than people who get adequate sleep.
Published in Scientific Reports, a study of women now shows what's happening in the body during chronic mild sleep deprivation.
After just six weeks of shortened sleep, the study found, the cells that line our blood vessels are flooded by damaging oxidants. And unlike well-rested cells, sleep-restricted cells fail to activate antioxidant responses to clear the destructive molecules.
The result: cells that are inflamed and dysfunctional, an early step in the development of cardiovascular disease. This is some of the first direct evidence to show that mild chronic sleep deficits cause heart disease.
Riddhi Shah, Vikash Kumar Shah, Memet Emin, Su Gao, Rosemary V. Sampogna, Brooke Aggarwal, Audrey Chang, Marie-Pierre St-Onge, Vikas Malik, Jianlong Wang, Ying Wei, Sanja Jelic. Mild sleep restriction increases endothelial oxidative stress in female persons. Scientific Reports, 2023; 13 (1) DOI: 10.1038/s41598-023-42758-y
Flu-resistant chickens
Birds with small alterations to one gene are highly resistant to avian flu
Scientists have created the world’s first flu-resistant chickens in an advance that could pave the way for gene-edited poultry. The birds, which had small alterations to one gene, were highly resistant to avian flu, with nine in 10 birds showing no signs of infection when exposed to a typical dose of the virus.
However, infections were not completely blocked, and scientists say this would have to be achieved before genetically engineered chickens could be introduced to farms, due to the risk of the virus evolving to become more dangerous to humans.
The three types of households with their typical characteristics and food waste behaviours. Credit: Trang Nguyen using Canva.com, CC BY-NC-ND
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The genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called E. This channel, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages tissues and contributes to the symptoms of COVID-19.
MIT chemists have now discovered the structure of the "open" state of this channel, which allows ions to flow through. This structure, combined with the "closed" state structure that was reported by the same lab in 2020, could help scientists figure out what triggers the channel to open and close. These structures could also guide researchers in developing antiviral drugs that block the channel and help prevent inflammation.
When SARS-CoV-2 infects cells, the E channel embeds itself inside the membrane that surrounds a cellular organelle called the ER-Golgi intermediate compartment (ERGIC). The ERGIC interior has a high concentration of protons and calcium ions, which the E channel transports out of ERGIC and into the cell cytoplasm. That influx of protons and calcium leads to the formation of multiprotein complexes called inflammasomes, which induce inflammation.
Previous research has shown that when SARS-CoV-2 viruses are mutated so that they don't produce the E channel, the viruses generate much less inflammation and cause less damage to host cells.
So the E channel is an antiviral drug target now. If you can stop the channel from sending calcium into the cytoplasm, then you have a way to reduce the cytotoxic effects of the virus.
Joao Medeiros-Silva et al, Atomic Structure of the Open SARS-CoV-2 E Viroporin, Science Advances (2023). DOI: 10.1126/sciadv.adi9007. www.science.org/doi/10.1126/sciadv.adi9007
Newly published research on indoor air quality shows wildfire smoke may linger in homes long after the initial blaze has been put out or winds have shifted.
The findings, published in Science Advances, show that wildfire smoke can attach to home surfaces like carpet, drapes or counters—extending the exposure for those inside and potentially causing health problems even after an initial cleaning activity by air purifiers.
However, the research also shows that surface cleaning—like vacuuming, dusting or mopping—can reduce exposure and limit risk. The team was able to show that the amount of smoke left on surfaces was proportional to the surface area that was cleaned. That means simple cleaning and specifically addressing large but little noticed spaces that may trap harmful compounds such as cabinets and HVAC systems could be beneficial right away.
Jienan Li et al, The persistence of smoke VOCs indoors: partitioning, surface cleaning, and air cleaning in a smoke-contaminated house, Science Advances (2023). DOI: 10.1126/sciadv.adh8263. www.science.org/doi/10.1126/sciadv.adh8263
Like human aging, stem cell maturation is considered a one-way process; once an undifferentiated stem cell goes down the path to become a specific type of cell, there is no turning back. But that does not seem to be the case with melanocyte stem cells (McSC), which give rise to cells that produce hair and skin pigments.
In a recent study, researchers investigated McSC in hair follicles and found that depending on microenvironment cues, McSCs can fluctuate between undifferentiated and differentiated states. The researchers also found that as the hair follicle ages, a larger number of melanocyte stem cells get stuck in an undifferentiated state, losing their ability to mature and produce melanin. Published in Nature, these results not only challenge the traditional view on how stem cells differentiate, but also offer clues to why hair turns gray with aging.
The researchers were surprised to find that McSC did not reside in an area called the bulge as previously thought, but were instead located in a compartment known as the hair germ. When the hair started to grow, the McSC transitioned to an intermediate differentiation state from which they either transformed into fully mature melanocytes at the base of the growing hair or moved up to the hair bulge where they stayed as undifferentiated cells. Then these stem cells homed back to the hair germ as the hair entered the resting phase of its growth cycle.
Once they realized that the maturation of these cells depended on their location, the team next investigated which signals within those compartments drove these changes. In the new study, the team found that nearby epithelial cells in the hair germ released Wnt ligands that mature the McSC, but these signals were suppressed in the bulge where the cells regained their undifferentiated features.
Melanocytes give hair its color, and hair pigmentation reduces with aging. So, the researchers wondered what would happen to McSC mobility in an aged hair follicle. To accelerate the aging of hair follicles, the researchers plucked mouse hair to induce regeneration of the follicles and observed McSCs over time. In aged mice, they found more of the stem cells in the bulge area rather than going back to the hair germ.
These findings suggested that as the hair follicle ages, McSC get stuck in a region where less pigment-inducing signals are present. This mechanism might explain why hair turns gray much more rapidly than it falls off.
Although scientists knew that cells could swing back and forth between their maturity states when there were tissue injuries, the study results are exciting as they reveal that dedifferentiation can also occur under a physiological condition.
Since the researchers conducted all of the experiments in mice, questions remain as to whether the same events are also seen in humans.
Sun Q, et al. Dedifferentiation maintains melanocyte stem cells in a dynamic niche. Nature. 2023;616(7958):774-782.
Rabbani P, et al. Coordinated activation of Wnt in epithelial and melanocyte stem cel.... Cell. 2011;145(6):941-955.
Monkey lives with gene-edited pig kidney A macaque lived for more than two years with a kidney from a gene-edited miniature pig — one of the longest-lasting interspecies organ transplants. It raises hopes that human organ shortages could one day be alleviated by using organs from donor animals. The donor pigs received 69 gene edits to prevent immune reactions after transplantation and to keep the organ healthy. Of the 15 monkeys that received a transplant, five survived for more than one year and one of those lived for 758 days.
https://www.nature.com/articles/s41586-023-06594-4.epdf?sharing_tok...
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care, JAMA (2023). DOI: 10.1001/jama.2023.20820. jamanetwork.com/journals/jama/ … 1001/jama.2023.20820
Part 2
A world-first clinical trial published in JAMA could provide an easy way to save tens of thousands of units of blood every year worldwide.
The trial, which involved more than 27,000 patients in 25 adult intensive care units (ICUs) across Canada, showed that taking less blood for lab tests using "small-volume" tubes reduced the need for almost one blood transfusion for every 10 patients. Most hospitals use standard tubes that automatically draw four to six milliliters (ml) of blood, but a typical laboratory test requires less than 0.5 ml of blood, meaning the rest (more than 90%) is wasted. Commercially available small-volume tubes have a weaker vacuum inside that automatically draws up to half as much blood. "While the amount of blood drawn per tube is relatively small, ICU patients typically require multiple blood samples taken multiple times every day. This can add up to significant blood loss that contributes to anemia, or low red blood cells. ICU patients are unable to produce more red blood cells to correct for this blood loss and often require treatment with a blood transfusion.
This trial showed that we can save one blood transfusion for every 10 ICU patients by simply switching to small-volume tubes for blood collection.
At a time when everyone is trying to find ways to make health care more sustainable, and preserve our supply of blood products, this study provides a simple solution that can be implemented without additional cost or negative effects. The study also has important implications for patients, as low red blood cells (anemia) can leave patients feeling tired and weak and is associated with can lead to other complications and longer hospital stays. While blood transfusions can usually correct anemia, there can be rare side effects, such as difficulty breathing, allergic reactions and infections.A small molecule previously shown to enhance strength in injured or old laboratory mice does so by restoring lost connections between nerves and muscle fibers, researchers have found.
The molecule, called PGE2, blocks the activity of an aging-associated enzyme, or gerozyme, called 15-PGDH that naturally increases in muscles as they age. The study showed that levels of the gerozyme increase in muscles after nerve damage and that it is prevalent in muscle fibers of people with neuromuscular diseases. The research is the first to show that damaged motor neurons—nerves connecting the spinal cord to muscles—can be induced to regenerate in response to a drug treatment and that lost strength and muscle mass can be at least partially regained. It suggests that, if similar results are seen in humans, the drug may one day be used to prevent muscle loss of muscle strength due to aging or disease or to hasten recovery from injury.
Mohsen A. Bakooshli et al, Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase, Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.adg1485
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