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Comment by Dr. Krishna Kumari Challa on Saturday

Scientists testing new scanning technology discover mysterious structure beneath an ancient Egyptian city

Archaeologists working in Egypt's Nile Delta may have discovered a tomb or temple dating back around 2,600 years while testing a new technology designed to locate structures buried deep beneath the surface. The team was studying the Buto (Tell el-Fara'in) site, the ruins of an ancient city that was occupied from the Predynastic period (around 3800 BCE) to the Early Islamic era (7th century CE).

During its long history, Buto was built, destroyed, and rebuilt and consequently has several layers, each potentially a rich source of archaeological remains. However, the oldest parts of the city are now buried beneath later ruins and thick mud deposits. This would make traditional digging difficult, time-consuming, and expensive as archaeologists have to move tons of debris or struggle with groundwater to reach lower levels. The technology helps guide them where to dig.

The researchers were trialing a multipronged approach that uses satellite radar (SAR) and electrical resistivity tomography (ERT).

The team started with the Sentinel-1 radar satellite to identify large-scale anomalies from space, as they describe in a paper published in the journal Acta Geophysica. When it detected something of interest, they followed up with ERT. The technology sends electrical currents between a series of electrodes placed in the ground to create a 3D model of subsurface structures based on how different materials conduct/resist electricity. This technique has been likened to an underground CT scan.

In the top three meters, the scans showed a layer of broken pottery and debris from the later Roman and Ptolemaic periods. However, at a depth of between three and six meters, the technology revealed a large, well-defined structure from the Saite period (around 2,600 years ago).

At this stage, the researchers thought it could be a large tomb or shrine. Next, they carried out a small 10 x 10 meter excavation, which uncovered mudbrick walls and religious artifacts where the sensors had predicted.

"The results of this study demonstrate the effectiveness of combining geophysical measurements and remote sensing data, which gave a very accurate vision in detecting buried settlements in a complex region," wrote the team in their paper.

Mohamed A. R. Abouarab et al, Multi-scale detection of buried archaeological elements across different occupation phases: an integrated approach using radar satellite imagery and electric resistivity tomography at Buto, northwestern Nile Delta of Egypt, Acta Geophysica (2026). DOI: 10.1007/s11600-026-01809-4

Comment by Dr. Krishna Kumari Challa on Saturday

Implantable 'living pharmacy' produces multiple drugs inside the body

A multi-institutional team of scientists has taken a crucial step toward implantable "living pharmacies"—tiny devices containing engineered cells that continuously produce medicines inside the body. In a new study published in Device, the team engineered cells to simultaneously produce three different biologics—an anti-HIV antibody, a GLP-1-like peptide used to treat type 2 diabetes, and leptin, a hormone that regulates appetite and metabolism. When implanted under the skin of a small animal model, the device kept drug-producing cells alive and stably delivered all three therapies at once.

Called HOBIT (hybrid oxygenation bioelectronics system for implanted therapy), the new system integrates the engineered cells with oxygen-producing bioelectronics. Roughly the size of a folded stick of gum, the design shields cells from the body's immune system while also providing cells with oxygen and nutrients to keep them alive and producing biologic drugs for several weeks.

With more work, living pharmacies hold the potential to treat chronic conditions with a single, long-lasting therapy—bypassing the need for patients to carry, inject or remember to take medications.

Design of a wireless, fully implantable platform for in-situ oxygenation of encapsulated cell therapies, Device (2026). DOI: 10.1016/j.device.2026.101106. www.cell.com/device/fulltext/S2666-9986(26)00058-X

Comment by Dr. Krishna Kumari Challa on March 27, 2026 at 11:06am

Eating about 4,200 mg sodium a day may raise heart failure risk 15%

Daily sodium intake averaging 4,200 mg, nearly double the recommended limit, is associated with a 15% higher risk of new-onset heart failure, independent of other health or sociodemographic factors. Modest sodium reduction could lower heart failure incidence and related healthcare costs, particularly in high-risk, low-income populations.

Excessive consumption of dietary sodium (salt) is a significant, independent risk factor for new-onset heart failure, according to a report from Vanderbilt Health, published in the Journal of the American College of Cardiology: Advances.
Consuming a population average of about 4,200 milligrams of dietary sodium a day (the recommended maximum is 2,300 milligrams) was associated with a 15% increase in the risk of incident (new) cases of heart failure.

"Even modest reductions in sodium consumption may significantly reduce the burden of heart failure in this high-risk population," the researchers report.
The increased risk of heart failure linked to sodium was independent of sociodemographic factors, including diet quality and caloric intake, as well as health conditions such as high blood pressure and high lipid blood levels.
Even a modest reduction in dietary salt, to 4,000 milligrams a day or less, could reduce heart failure cases by 6.6% over 10 years, the researchers predicted.

Leonie Dupuis et al, Dietary Sodium Intake and Risk of Incident Heart Failure in the Southern Community Cohort Study, JACC: Advances (2026). DOI: 10.1016/j.jacadv.2026.102651

Comment by Dr. Krishna Kumari Challa on March 27, 2026 at 10:59am

Severe strokes may 'rejuvenate' undamaged brain regions

Analysis of MRI data from over 500 stroke survivors indicates that while severe strokes accelerate aging in the damaged brain hemisphere, undamaged regions—especially the contralesional frontoparietal network—exhibit a younger structural profile. This suggests adaptive neuroplasticity, where unaffected areas reorganize to compensate for lost motor function. These findings may inform personalized rehabilitation strategies.

Gilsoon Park et al, Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study, The Lancet Digital Health (2026). DOI: 10.1016/j.landig.2025.100942

Comment by Dr. Krishna Kumari Challa on March 27, 2026 at 10:55am

Influencers promoting prescription drugs on social media pose public health risks
Influencer promotion of prescription drugs on social media increases the risk of misinformation, with exaggerated benefits and omitted side effects commonly observed. Current FDA and FTC regulations are insufficient for this context, and inconsistent disclosure blurs the line between personal stories and advertisements. Stronger guidelines, standardized disclosures, and improved public media literacy are recommended to address these risks.

Sascha Gell et al, Prescription Drug Promotion by Social Media Influencers, JAMA Network Open (2026). DOI: 10.1001/jamanetworkopen.2026.2738

Comment by Dr. Krishna Kumari Challa on March 27, 2026 at 10:49am

Tiny rotating hairs inside a microscopic cavity decide where your organs will grow
Organ asymmetry in humans originates during embryonic development, where rotating cilia in the embryonic node generate a directional fluid flow that influences left-right organ placement. Using an artificial node with magnetically controlled cilia and advanced simulations, it was demonstrated that both cilia-induced flow and morphogen transport together break left-right symmetry.

Heart to the left. Liver to the right. That's where you'll find these organs in a healthy human body, but surprisingly, in some people, the heart is on the right and the liver on the left. This normal or abnormal asymmetry can be traced back to your embryonic stage. In the early days of your development, a small fluid-filled cavity known as an embryonic node forms in your embryo. Inside, tiny micro-hairs known as cilia create a flow pattern that steers where organs grow in your body.

Researchers have revealed key details behind the process by building a world-first artificial embryonic node—using synthetic magnetically controlled cilia to generate a flow pattern—and then explore what happens in the node using advanced simulations. They published their findings on March 25 in the journal Science Advances.

It can be traced all the way back to your first period as an embryo. And it has to do with what happens in something called an embryonic node.

An embryonic node is a small cavity that contains a fluid (made up of water, proteins, hormones, and other substances). The top is closed off by a membrane, while the bottom layer is lined with a few hundred tiny micro-hairs called cilia. The whole node is just a few hundred micrometers across. "The cilia in the embryonic node rotate in the same direction, making a tilted conical motion. This generates an anticlockwise fluid flow inside the node, and it's this flow that is known to play a key role in the left-right symmetry.

Tanveer ul Islam et al, Artificial embryonic node elucidates the role of flow in left-right symmetry breaking in vertebrates, Science Advances (2026). DOI: 10.1126/sciadv.aec2328

Comment by Dr. Krishna Kumari Challa on March 27, 2026 at 10:38am

Why cells respond 'incorrectly' in old age
Aging cells exhibit altered responses to external signals due to changes in chromatin structure within the nucleus. With age, chromatin becomes more open, leading to less accurate gene expression and increased activation of inappropriate genes. This impairs essential cellular processes and may contribute to age-related diseases, suggesting that targeting chromatin structure could support healthier aging.
Some of the signs of aging in human cells originate in the cell nucleus, because the packaged form of DNA changes with age. This has now been demonstrated by  researchers. It means that older cells can no longer react appropriately to external stimuli, and this can even lead to diseases. This insight could help scientists to curb such alterations and support better health in old age.

As we age, our cells age with us. Although they remain active, they become less flexible, stop dividing and sometimes respond incorrectly to signals. The reason for this lies in the cell nuclei, specifically in the chromatin—the packaged form of our DNA.

This is the finding of a study by researchers  who analyzed samples of skin cells taken from people of different ages in the laboratory. They have published their findings in the journal PNAS.

Using a microscope and molecular biological methods, the scientists examined how various skin cells reacted to a specific chemical messenger when mechanical tension was applied. They compared skin cells from ten-year-old children with those from 75-year-olds.

 the response of older people's cells to the same stimuli was different and significantly weaker. The scientists were able to attribute this to a specific cause: the chromatin in the cell nucleus changes with age. As a result, certain genes—sections of DNA that belong together—can no longer be read as accurately.

This process, known as gene expression, is important in order to produce the proteins required by the organism, because the genes store the instructions for building those proteins. However, if the shape of the chromatin changes with age, other processes may be triggered instead, which can harm the organism.

Shivashankar, G. V., Chromatin accessibility regulates age-dependent nuclear mechanotransduction, Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2522217123. doi.org/10.1073/pnas.2522217123

Comment by Dr. Krishna Kumari Challa on March 26, 2026 at 1:33pm

The cloning limit does exist

After 20 years and more than 30,000 cloning attempts, researchers have found the limit on the number of times that a single mouse can be serially re-cloned — their attempts failed after 58 generations. The cloned mice looked normal and lived as long as normal mice, but accumulated mutations at an unusually high rate, which could be why attempts to clone them were eventually unsuccessful, the team says. The findings suggest that asexual reproduction is ultimately unsustainable for mice, and potentially for other mammals, too.

https://www.nature.com/articles/s41467-026-69765-7?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa on March 26, 2026 at 1:06pm

Walking pace may outperform blood pressure and cholesterol in predicting mortality risk, study suggests
Analysis of over 400,000 UK adults indicates that walking pace is a stronger predictor of mortality risk than blood pressure or cholesterol, particularly in individuals with chronic health conditions. Incorporating simple physical measures such as walking pace, handgrip strength, and resting heart rate enhances mortality risk prediction beyond traditional clinical factors.

The Utility of Measures of Physical Behavior, Function, and Fitness as Predictors of Mortality, Mayo Clinic Proceedings (2026). DOI: 10.1016/j.mayocpiqio.2026.100710

Comment by Dr. Krishna Kumari Challa on March 26, 2026 at 1:01pm

The study reported that:

Out of nearly 3 million pregnancies, approximately 1% (n = 28,641) were affected by placental abruption.
During a 28-year follow-up period, children born to mothers who had a placental abruption during the pregnancy were 4.6 times more likely to die from cardiovascular disease than children born to mothers who experienced a normal placental separation from the uterus after delivery.
Children born to mothers who had a placental abruption faced nearly three times higher risk of being hospitalized for heart-related complications during the next 28 years. These conditions included heart failure, ischemic heart disease, heart attack, blocked arteries, and general cardiovascular disease.
The children's risk of stroke hospitalization was 2.4 times higher than for children whose mothers did not have a placental abruption.
These heart disease and stroke risks associated with abruption were even higher among children younger than 1 year old.
The association between placental abruption and increased cardiovascular risk remained similar after conducting an additional analysis contrasting cardiovascular disease risks between biological siblings (each mother served as their own control), suggesting that genetic and environmental factors did not explain this relationship.

Placental abruption is a sudden and often catastrophic event that cannot be prevented and comes with no warning. Older women or those expecting more than one baby, such as twins or triplets, have an increased risk of developing this condition.
Avoiding smoking, drinking alcohol, and using illegal drugs (particularly, cocaine) and maintaining good blood pressure control are also important, as they are linked to placental abruption.

Cardiovascular Disease in Singleton Offspring Born of Pregnancies Complicated by Placental Abruption: A Population-Based Retrospective Cohort Study, DOI: 10.1161/JAHA.125.045199

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