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Comment by Dr. Krishna Kumari Challa on June 27, 2025 at 2:37pm

Exercise sends 'mechanical messages' to cells, unlocking new energy pathways

Scientists  have made a breakthrough in understanding how cells in our body respond to physical activity and exercise.

Researchers discovered a direct mechanical signal that travels from outside the cell into the energy-producing parts of the cell, which could change the way we think about exercise and its benefits.

Researchers found a protein production factory in the cell, the endoplasmic reticulum, can sense external mechanical forces, such as stretching or strain and transmit them deep into the cell.

The process helps regulate energy production in the cell and maintains tissue health.

Cells constantly experience physical forces, especially in load-bearing tissues such as tendon, muscle and lung. Researchers found that the endoplasmic reticulum plays a central role in converting these mechanical cues into metabolic responses, controlling how cells produce energy and prevent tissue damage.

They discovered that while moderate physical activity and exercise could enhance energy production in cells, excessive strain or injury could disrupt this process, leading to cellular damage.

 Ziming Chen et al, External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics, Science Advances (2025). DOI: 10.1126/sciadv.ads6132

Comment by Dr. Krishna Kumari Challa on June 27, 2025 at 2:10pm

Tech giants' net zero goals verging on fantasy: Researchers

The credibility of climate pledges by the world's tech giants to rapidly become carbon neutral is fading fast as they devour more and more energy in the race to develop AI and build data centers, researchers warned this week.

Apple, Google and Meta said they would stop adding CO₂ into the atmosphere by 2030, while Amazon set that target for 2040.

Microsoft promised to be "net negative"—pulling CO₂ out of the air—by the end of this decade.

But those vows, made before the AI boom transformed the sector, are starting to look like a fantasy even as these companies have doubled down on them, according to independent analysts.

"The greenhouse gas emissions targets of tech companies appear to have lost their meaning", the researchers say.

Source: News agencies

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Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 11:47am

Synthetic protein jams up diseased cells
A synthetic ‘killswitch’ protein, just 17 amino acids long, can jam droplet-like structures that coordinate key cellular processes such as cancer, viral replication, gene expression and more. The droplet-like structures have no membranes and help to organize proteins and RNA molecules so that they can perform specific tasks efficiently and precisely. The killswitch infiltrates the droplets and fixes them in place. In a pair of experiments, researchers found that the killswitch could reduce leukaemia cell proliferation in mice and also curtail the production of viral particles in infected cells.

https://www.nature.com/articles/s41586-025-09141-5?utm_source=Live+...

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 10:55am

Cold drinks may trigger irregular heartbeat in some people with atrial fibrillation (Afib)

It may sound strange, but for some people, cold drinks may be to blame for sudden episodes of atrial fibrillation (Afib), a common heart rhythm disorder.

A recent survey sheds light on this phenomenon, dubbed "cold drink heart" (CDH). Researchers found that a surprising number of people with Afib report cold beverages as a trigger for their irregular heartbeats. In fact, for half of the survey participants who identified cold ingestion as an Afib trigger, avoiding cold drinks and foods completely eliminated their episodes. Others found relief by modifying their habits, such as letting drinks warm up, skipping the straw, or avoiding gulping.

Why might a cold drink send your heart out of rhythm?

While the exact mechanism isn't fully understood, it's likely related to the vagus nerve, which plays a role in regulating heart rate. The sudden temperature change from a cold drink might stimulate this nerve, leading to changes in heart rhythm in susceptible individuals, say experts.

It's important to remember that not everyone with Afib will experience this trigger. However, if you notice a connection between cold drinks and your Afib episodes, it's worth discussing with your doctor. Simple lifestyle changes, like avoiding very cold beverages or letting them warm up, could make a significant difference.

This doesn't replace the need for medical evaluation and treatment for Afib. If you experience any symptoms like heart palpitations, shortness of breath, or dizziness, seek medical attention promptly.

The survey, published in the Journal of Cardiovascular Electrophysiology, is the first to systematically explore the link between cold drinks and Afib. While more research is needed, the findings suggest that for some, a simple change in drinking habits could be a key to managing their condition.

Daniel D. DiLena et al, Characterizing Patients With Cold Drink‐Triggered Atrial Fibrillation, Journal of Cardiovascular Electrophysiology (2025). DOI: 10.1111/jce.16753

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 10:17am

Global study links severe bleeding after childbirth to increased risk of cardiovascular disease

Women who experience severe bleeding after giving birth face elevated risks to their cardiovascular health that can persist for up to 15 years—a new analysis of data from over 9.7 million women across Europe, North America and Asia shows.

The findings, which follow a review of research data, some of which date back to 1986, suggest that women who experience postpartum hemorrhage (PPH) have an increased risk to both cardiovascular conditions—such as heart failure, stroke, and ischemic heart disease—and thromboembolic events, such as blood clots.

Published in The Journal of Maternal-Fetal & Neonatal Medicine, the results reveal these cardiovascular conditions are 1.76 times more likely, while thromboembolic incidents are 2.10 times more likely.

While this increased risk is particularly acute in the first year after giving birth, it can persist for up to 15 years, especially among women with complications that lead to high blood pressure during pregnancy, such as preeclampsia.

PPH has long been seen as an emergency that ends once the bleeding stops. But these new findings show it may have lasting effects on a woman's heart health, even years after childbirth.

Postpartum hemorrhage and long-term cardiovascular disease risk: a comprehensive systematic review and meta-analysis, The Journal of Maternal-Fetal & Neonatal Medicine (2025). DOI: 10.1080/14767058.2025.2507103

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 9:58am

How diverse brain cells reach a decision together

Every decision begins invisibly. Long before someone acts, the brain is already hard at work gathering evidence, weighing options, and gradually committing to a choice. But even when faced with the same evidence, people can arrive at different outcomes, especially when the decision is difficult.

How the brain, made up of billions of specialized cells, makes these split-second decisions has largely been a mystery, though.

Now, new findings  shed light on how diverse brain cells come together to guide a unified decision. The researchers found that while individual neurons have perplexingly complex responses, their activity is shaped by a shared structure that ultimately guides the brain toward a unified choice.

Though each neuron had a different individual response, they all appeared to share the same underlying potential landscape.

Think of it like a group of skiers descending a mountain. Each prefers a slightly different path, but all are shaped by the same slope beneath them. Similarly, each neuron has its own preference and activity, but the group of cells collectively in the premotor cortex takes a coordinated journey and gradually settles into a stable state that represents the decision, say the researchers.

Tatiana Engel, The dynamics and geometry of choice in the premotor cortex, Nature (2025). DOI: 10.1038/s41586-025-09199-1. www.nature.com/articles/s41586-025-09199-1

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 9:52am

Nitrate in drinking water linked to preterm birth rates

Even low levels of nitrate—a common agricultural runoff and drinking water contaminant—are associated with increased risks of preterm birth and low birthweight babies, according to a study published in PLOS Water.

Nitrate is a naturally occurring compound increasingly found in inorganic fertilizers and, through runoff, in groundwater. When consumed by humans, nitrates can interfere with the blood's capacity to carry oxygen.

After controlling for maternal and paternal characteristics as well as seasonal variation, the study found that early prenatal exposure to greater than 0.1 mg/L nitrate—just 1% of the current EPA limit—was associated with an increase in preterm birth (Est.=+0.66%-points; C.I.=0.31, 1.01) and early prenatal exposure to greater than 5 mg/L nitrate was associated with an increased risk of low birth weight babies (Est.=+0.33%-points; C.I.=0.03, 0.63). There were no additional risks conferred by exposure to elevated levels of nitrate, above 10 mg/L.

PLOS Water (2025). DOI: 10.1371/journal.pwat.0000329

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 9:37am

Why most cats prefer to sleep on their left side?

An international research team that analyzed several hundred YouTube videos of sleeping cats found that they prefer to sleep on their left side. The researchers see this bias as an evolutionary advantage because it favors hunting and escape behavior after waking up.

All animals are particularly vulnerable while sleeping. Cats sleep around 12 to 16 hours a day, preferably in elevated places where their predators can only access them from below.

Researchers analyzed 408 publicly available YouTube videos in which a single cat was clearly visible with its entire body sleeping on one side for at least 10 seconds.

Two-thirds of the videos showed cats sleeping on their left side.

The explanation: Cats that sleep on their left side perceive their surroundings upon awakening with their left visual field, which is processed in the right hemisphere of the brain. This hemisphere is specialized in spatial awareness, the processing of threats and the coordination of rapid escape movements. If a cat sleeps on its left shoulder and wakes up, visual information about predators or prey goes directly to the right hemisphere of the brain, which is best in processing them. "Sleeping on the left side can therefore be a survival strategy," the researchers conclude.

Sevim Isparta et al, Lateralized sleeping positions in domestic cats, Current Biology (2025). DOI: 10.1016/j.cub.2025.04.043

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 9:00am

Scientists detect deep Earth pulses beneath Africa

Research led by Earth scientists has uncovered evidence of rhythmic surges of molten mantle rock rising from deep within the Earth beneath Africa. These pulses are gradually tearing the continent apart and forming a new ocean.

The findings, published in Nature Geoscience, reveal that the Afar region in Ethiopia is underlain by a plume of hot mantle that pulses upward like a beating heart.

The team's discovery reveals how the upward flow of hot material from the deep mantle is strongly influenced by the tectonic plates—the massive solid slabs of Earth's crust—that ride above it.

Over millions of years, as tectonic plates are pulled apart at rift zones like Afar, they stretch and thin—almost like soft plasticine—until they rupture. This rupturing marks the birth of a new ocean basin.

 Mantle upwelling at Afar triple junction shaped by overriding plate dynamics, Nature Geoscience (2025). DOI: 10.1038/s41561-025-01717-0

Comment by Dr. Krishna Kumari Challa on June 26, 2025 at 8:51am

Scientists discover unknown organelle inside our cells

The discovery of an unknown organelle inside our cells could open the door to new treatments for devastating inherited diseases.

The organelle, a type of specialized structure, has been dubbed a "hemifusome" by its discoverers. This little organelle has a big job helping our cells sort, recycle and discard important cargo within themselves, the scientists say. The new discovery could help scientists better understand what goes wrong in genetic conditions that disrupt these essential housekeeping functions.

Researchers think the hemifusome helps manage how cells package and process material, and when this goes wrong, it may contribute to diseases that affect many systems in the body.

 Amirrasoul Tavakoli et al, Hemifusomes and interacting proteolipid nanodroplets mediate multi-vesicular body formation, Nature Communications (2025). DOI: 10.1038/s41467-025-59887-9

 

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