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Comment by Dr. Krishna Kumari Challa on September 4, 2021 at 11:31am

Drug cocktail reduces aging-associated disc degeneration

Chronic back pain affects  millions of  adults in the world. Degeneration of the discs that cushion and support vertebrae, a common occurrence of aging, is a major contributor to low back pain. Although a widespread condition, few treatments are available.

With age, every tissue in the body accumulates senescent cells. Senescent cells secrete destructive enzymes and inflammatory proteins that affect nearby healthy cells. Senolytic drugs remove these deteriorating cells, leaving room for new cells to replace them. The idea is that removing senescent cells from a tissue will improve the tissue's function.

New research has shown  that treating mice with a drug cocktail that removes aging cells reduces disc degeneration. The findings, reported in Nature Communications on September 3rd, show how a novel approach to preventing age-related disc degeneration may pave the way for treating chronic back pain.

The findings show that senolytic drugs—ones already approved for use in clinical trials—can mitigate disc degeneration that occurs with aging.

Just because the drugs work in one tissue doesn't mean they will also work in another. Every tissue is different and should be treated differently.

Young and middle-aged mice given the senolytic cocktail showed less disc degeneration and fewer senescent cells by the time they reached an advanced age compared to mice given a placebo.

"Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice." Nature Communications (2021) , DOI: 10.1038/s41467-021-25453-2

https://medicalxpress.com/news/2021-09-drug-cocktail-aging-associat...

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 2:00pm

How Do Ants Tunnel So Well?

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 12:13pm

CO₂ stays in the atmosphere for a very, very long time. Many thousands of years. So that greenhouse gas accumulates, and the 'blanket' around the earth thickens. The unique thing about methane is that it halves in the atmosphere in just over 8 years. The other half becomes CO₂. So if you emit 100 kilos of methane today, in 8.5 years there will be 50 kilos left, and after another 8.5 years only 25 kilos, and so on," Vellinga explains. "That CO₂ has gone through what is known as the short carbon cycle: it was converted by grass, corn, etc. into plant material, which the cow converts back into CO₂ and CH₄. And that CH₄ becomes CO₂ again pretty quickly. Nothing to worry about, you might say."

"But be careful not to make the problem too small. Before you know it, it seems as if there is nothing wrong with methane. On the contrary. As long as methane is in the atmosphere, it contributes very strongly to warming. Over the lifetime of methane, this is as much as 80 to 100 times more than CO₂.

But the advantage is that it disappears quickly. Reducing methane emissions can cause the concentration of methane in the atmosphere to drop and therefore even reduce the greenhouse effect. When reducing CO₂, the current greenhouse effect remains the same and only does not increase. So reducing methane is more effective than reducing CO₂. But it has to be done both ways."

https://phys.org/news/2021-09-fact-methane.html?utm_source=nwletter...

Part 2

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Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 12:12pm

How harmful is methane?

Methane contributes to global warming; it is therefore a greenhouse gas. Of all the methane produced in some developed countries, 70% comes from livestock farming. A substantial percentage. But how harmful is it? Because, unlike other greenhouse gasses, methane breaks down relatively quickly in the atmosphere. 

Greenhouse gasses are important. They form a blanket around the earth. Without greenhouse gasses, it would be unbearably cold on earth. The problem with the greenhouses gasses is that we too much of them. The blanket becomes so thick, that the earth's temperature rises. This causes periods of drought and in other places too much precipitation, the polar caps melt, and so on.

there are three greenhouse gasses: carbon dioxide (CO₂), methane (CH₄) and nitrous oxide (N₂O). Roughly speaking, you can say that all three are created during the breakdown or combustion of organic substances. CO₂ (and NO_x) are mainly created through the combustion of diesel, lignite or gasoline. Not only in transport and traffic, but also in production processes. From the concrete in your house to the staples in your furniture, almost everything in our lives produces CO₂ during its production.

Methane is released during the breakdown of organic substances. For example, in the gastrointestinal tract of animals. Ruminants (cows, goats, sheep) in particular produce a lot of methane. Methane is also 34 times more powerful than carbon dioxide. So, the earth warms up extra fast when there is more methane in the atmosphere. N₂O is created in processes where nitrogen compounds play a role: in manure storage and manure application."

part 1

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 12:07pm

Decaying forest wood releases 10.9 billion tons of carbon yearly, which will increase with climate change

If you've wandered through a forest, you've probably dodged dead, rotting branches or stumps scattered on the ground. This is "deadwood," and it plays several vital roles in forest ecosystems.

It provides habitat for small mammals, birds, amphibians and insects. And as deadwood decomposes it contributes to the ecosystem's cycle of nutrients, which is important for plant growth.

But there's another important role we have little understanding of on a global scale: the carbon deadwood releases as it decomposes, with part of it going into the soil and part into the atmosphere. Insects, such as termites and wood borers, can accelerate this process.

The world's deadwood currently stores 73 billion tons of carbon. Our new research in Nature has, for the first time, calculated that 10.9 billion tons of this (around 15%) is released into the atmosphere and soil each year—a little more than the world's emissions from burning fossil fuels.

But this amount can change depending on insect activity, and will likely increase under climate change. It's vital deadwood is considered explicitly in all future climate change projections.

Sebastian Seibold et al, The contribution of insects to global forest deadwood decomposition, Nature (2021). DOI: 10.1038/s41586-021-03740-8

https://phys.org/news/2021-09-forest-wood-billion-tons-carbon.html?...

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Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 11:12am

Nano 'camera' made using molecular glue allows real-time monitoring of chemical reactions

Researchers have made a tiny camera, held together with 'molecular glue' that allows them to observe chemical reactions in real time.

The device, made by a team from the University of Cambridge, combines tiny semiconductor nanocrystals called quantum dots and gold nanoparticles using molecular glue called cucurbituril (CB). When added to water with the molecule to be studied, the components self-assemble in seconds into a stable, powerful tool that allows the real-time monitoring of chemical reactions.

The camera harvests light within the semiconductors, inducing electron transfer processes like those that occur in photosynthesis, which can be monitored using incorporated gold nanoparticle sensors and spectroscopic techniques. They were able to use the camera to observe chemical species which had been previously theorized but not directly observed.

The platform could be used to study a wide range of molecules for a variety of potential applications, such as the improvement of photocatalysis and photovoltaics for renewable energy. The results are reported in the journal Nature Nanotechnology.

Földes, T. et al, Nanoparticle surfactants for kinetically arrested photoactive assemblies to track light-induced electron transfer, Nat. Nanotechnol. (2021). DOI: 10.1038/s41565-021-00949-6 , www.nature.com/articles/s41565-021-00949-6

https://phys.org/news/2021-09-nano-camera-molecular-real-time-chemi...

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 10:57am

Birds and mammals evolve faster if their home is rising

The rise and fall of Earth's land surface over the last three million years shaped the evolution of birds and mammals, a new study has found, with new species evolving at higher rates where the land has risen most.

Researchers at the University of Cambridge have combined reconstructions of the Earth's changing surface elevations over the past three million years with data on climate change over this timeframe, and with bird and mammal species' locations. Their results reveal how species evolved into new ones as land elevation changed—and disentangle the effects of elevation from the effects of climate.

The study found that the effect of elevation increase is greater 

than that of historical climate change, and of present-day elevation and temperature, in driving the formation of new species – 'or speciation'.

In contrast to areas where land elevation is increasing, elevation loss was not found to be an important predictor of where speciation happens. Instead, present-day temperature is a better indicator of speciation in these areas.

The results are published today in the journal Nature Ecology and Evolution.

 Global topographic uplift has elevated speciation in mammals and birds over the last 3 million years, Nature Ecology and Evolution (2021). DOI: 10.1038/s41559-021-01545-6 , www.nature.com/articles/s41559-021-01545-6

https://phys.org/news/2021-09-birds-mammals-evolve-faster-home.html...

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 9:50am

A gecko-inspired robot's crash-landing correction

Comment by Dr. Krishna Kumari Challa on September 3, 2021 at 9:47am

Study explores the influence of the X-chromosome on brain anatomy

Past neuroscience research suggests that common differences in people's genetic profiles can explain a significant proportion of variations in people's brain anatomy. In more specific terms, they found that neuroanatomical variation is partly explained by genetic variation.

Scientists have hypothesized that the X-chromosome has a particularly crucial influence on the brain, as it is known to be associated with the expression of many genes. In addition, several types of intellectual disabilities have been found to be related with mutations of genes on the X chromosome.

All existing studies investigating the role of genetics on brain anatomy excluded the X-chromosome, which accounts for about 5% of our genomes. it would be important to address this gap because—beyond the basic need to complete the missing analysis—there were lot of existing hints that the X-chromosome might actually have a special capacity to explain variation in brain anatomy.

So  if a common genetic variation explains 30% of variation in total brain volume, then a chromosome which represents 10% of the genome would explain 3% of variation in total brain volume.

The X-chromosome consists of approximately 5% of the total genome. Taking this into consideration, researchers calculated the proportion of anatomical variation that could be explained by the X-chromosome. They found that given its known size and the percentage of the human genome it represents, the proportion they calculated differed significantly from the expected proportion.

The main take-aways from our studies are that the X-chromosome does indeed 'punch above its weight' in its capacity to explain differences in brain anatomy and that this phenomenon seems to be concentrated in particular brain systems important for complex thinking, decision making and action.

In terms of practical implications— this finding tells us that we really do need to put an end to exclusion of the X-chromosome from genetic analyses of the brain and related traits such as cognition and behavior.

The findings gathered by this team of researchers significantly enrich the current understanding of the X-chromosome's role in human neurodevelopment.

X-chromosome influences on neuroanatomical variation in humans. Nature Neuroscience(2021). DOI: 10.1038/s41593-021-00890-w

https://medicalxpress.com/news/2021-09-explores-x-chromosome-brain-...

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Comment by Dr. Krishna Kumari Challa on September 2, 2021 at 12:23pm

Biologists Just Got Closer to The DNA Secrets That Stop Species From Interbreeding

We think of DNA as the vitally important molecules that carry genetic instructions for most living things, including ourselves. But not all DNA actually codes proteins; now, we're finding more and more functions involving the non-coding DNA scientists used to think of as 'junk'.

A new study suggests that satellite DNA – a type of non-coding DNA arranged in long, repetitive, apparently nonsensical strings of genetic material – may be the reason why different species can't successfully breed with each other.

It appears that satellite DNA plays an essential role in keeping all of a cell's individual chromosomes together in a single nucleus, through the work of cellular proteins.

According to biologists Madhav Jagannathan and Yukiko Yamashita who authored the new study, that important role is managed differently in each species, leading to genetic incompatibility. The clash of the different strategies between species may be what causes chromosomes to scatter outside of the nucleus, at least in part, preventing reproduction.

"We propose a unifying framework that explains how the widely observed satellite DNA divergence between closely related species can cause reproductive isolation," they write in their paper.

This "satellite DNA divergence" has been well established in previous research, leading to suspicions about its role in speciation. In the case of the chimpanzee genome and the human genome, for example, the protein-coding DNA is almost identical, while the 'junk' DNA is almost entirely different.

https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msa...

https://www.sciencealert.com/junk-dna-could-be-why-different-specie...

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