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Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 11:15am

Scientists clarify the neuronal basis of the mathematical concept of 'zero'

Despite its importance for mathematics, the neuronal basis of the number zero in the human brain was previously unknown. Researchers  have now discovered that individual nerve cells in the medial temporal lobe recognize zero as a numerical value and not as a separate category "nothing."

The results have now been published in the journal Current Biology.

The concept of the number zero has been central to the development of number systems and mathematics and is widely regarded as one of humanity's most important cultural achievements.

Unlike other numbers such as one, two or three, which represent countable quantities, zero means the absence of something countable and at the same time still has a numerical value.

In contrast to positive natural numbers, the concept of the number zero only emerged late in human history over the last two millennia. This is also reflected in childhood development, as children are typically only able to understand the concept of zero and associated arithmetic rules at around the age of six.

Number zero is a numerical value for neurons

In the experiments conducted , there was a numerical distance effect in which neurons reacted weaker, but measurably, also to the neighboring number one.

So at the neuronal level, the concept of zero is not encoded as a separate category 'nothing,' but as a numerical value integrated with other, countable numerical values at the lower end of the number line.

For Arabic numerals, however, this effect was not found at either the neural or behavioral level. From this, the researchers recognize the importance of symbolic representations, for example through Arabic numerals, for the integration of the number zero on the number line in the human brain.

Esther F. Kutter et al, Single-neuron representation of nonsymbolic and symbolic number zero in the human medial temporal lobe, Current Biology (2024). DOI: 10.1016/j.cub.2024.08.041

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 10:00am

Gut microbiome communities found to have enhanced resilience to drugs

Many human medications can directly inhibit the growth and alter the function of the bacteria that constitute our gut microbiome. Researchers have now discovered that this effect is reduced when bacteria form communities.

In a first-of-its-kind study, researchers compared a large number of drug-microbiome interactions between bacteria grown in isolation and those part of a complex microbial community. Their findings were recently published in the journal Cell.

For their study, the team investigated how 30 different drugs (including those targeting infectious or noninfectious diseases) affect 32 different bacterial species. These 32 species were chosen as representative of the human gut microbiome based on data available across five continents.

They found that when together, certain drug-resistant bacteria display communal behaviors that protect other bacteria that are sensitive to drugs. This "cross-protection" behavior allows such sensitive bacteria to grow normally when in a community in the presence of drugs that would have killed them if they were isolated.

Up to half of the cases where a bacterial species was affected by the drug when grown alone, it remained unaffected in the community.

The researchers then dug deeper into the molecular mechanisms that underlie this cross-protection. The bacteria help each other by taking up or breaking down the drugs. These strategies are called bioaccumulation and biotransformation respectively.

However, there is also a limit to this community strength. The researchers saw that high drug concentrations cause microbiome communities to collapse and the cross-protection strategies to be replaced by "cross-sensitization." In cross-sensitization, bacteria which would normally be resistant to certain drugs become sensitive to them when in a community—the opposite of what the authors saw happening at lower drug concentrations.

Just like the bacteria they studied, the researchers also took a community strategy for this study, combining their scientific strengths.

Sarela Garcia-Santamarina et al, Emergence of community behaviors in the gut microbiota upon drug treatment, Cell (2024). DOI: 10.1016/j.cell.2024.08.037

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 9:54am

Yeast chit-chat: How microorganisms communicate food shortages

To grow and survive, tiny organisms such as yeast must sometimes adapt their nutrient sources in response to changes in the environment. FMI researchers have now found that yeast cells communicate with each other to use less favorable nutrients if they foresee a shortage of their favorite food. This communication is facilitated by secreted molecules that interact with a protein in mitochondria, the cells' energy factories.

The findings reveal a crucial mechanism that allows microorganisms to choose the right menu. The research is published in The EMBO Journal.

Previous research had identified specific molecules called Nitrogen Signaling Factors (NSFs) as essential components of the mechanism that yeast cells use to communicate.

The researchers now found that NSFs interact directly with a mitochondrial protein involved in metabolism, maximizing growth in response to an imminent change in nutrient availability. The findings unveil a key communication mechanism that allows yeast cells to be frugal with food. Strategies for growth and survival are conserved across species, and yeast has served as a tremendous model organism.

The researchers  discovered that increasing NSFs levels lead to changes in the gene expression program of yeast cells, prompting them to switch to alternative nutrient sources.

Shin Ohsawa et al, Nitrogen signaling factor triggers a respiration-like gene expression program in fission yeast, The EMBO Journal (2024). DOI: 10.1038/s44318-024-00224-z

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 9:33am

Ant queens cannibalize their sick offspring and 'recycle' them, new study reveals

Instead of nurturing their sick young, ant queens eat their infected offspring at the first sign of illness then "recycle" them into energy to produce new eggs, a new study led by the University of Oxford has shown. The findings have been published in Current Biology.

Eek!  Nature and Universe don’t care what happens to which mass of atoms!

Ant queens typically found new colonies on their own, and at the early stages are highly vulnerable to their brood being wiped out by disease. Researchers at Oxford's Department of Biology theorized that killing off sick larvae before they become infectious could be a strategy used by queens to combat this threat.

To test this, the researchers presented founding queens of the black garden ant (Lasius niger) with larvae that had been infected with a fungal pathogen Metarhizium for 24 hours. At this point, the infection was lethal, but not yet transmissible. The queens cannibalized 92% of the infected larvae—leaving no remains—but only 6% of control larvae which had not been infected.

Once the queens find a sick larva in the brood pile they get to work immediately and spend several hours chewing them up until they're all consumed.

Despite the potential risk of infection, all queens survived after eating the infected larvae. The researchers suggest the queens may protect themselves by swallowing an acidic, antimicrobial venom which they produce from a special gland at the end of their abdomen. Indeed, some of the queens were seen massaging the opening of this gland during and after cannibalism.

The queens who cannibalized their infected larvae went on to lay 55% more eggs than non-cannibalizing control queens, indicating that the nutrients from the ingested offspring were recycled for reproduction.

Flynn Bizzell et al, Ant queens cannibalise infected brood to contain disease spread and recycle nutrients, Current Biology (2024). DOI: 10.1016/j.cub.2024.07.062

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 9:18am

Who's to blame when climate change turns the lights off?

Deadly Storms have flooded recently large areas of central Europe and the UK, destroying homes and displacing thousands of people.

With the flooding of sub-stations, the scouring of the foundations of pylons and river embankment failures, the rainstorm has also caused power outages many miles away. This will create yet more disruption as sewage pumping stations stall, train and tram services halt and vehicle charging points fail.

The UK saw this ripple of infrastructure failure in the 2007 summer floods.

India too saw this ripple effect  in this monsoon season.

 All systems fail occasionally. But infrastructure is increasingly vulnerable to disruptions caused by extreme weather, which is being made more severe and frequent as a result of climate change.

Your home may not be in the path of the next storm but the infrastructure it relies on might be.

Source:  original article.

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Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 9:07am

Tap water is also a greener option. Plastic bottles make up the second most common ocean pollutant, accounting for 12% of all plastic waste. Globally, just 9% of these bottles are recycled, meaning that most end up in landfill or incinerators, or are 'exported' to low and middle income countries, to deal with, begging the question of social justice, they say.

Apart from the waste generated, the process of extracting the raw materials and manufacturing plastic bottles significantly contributes to greenhouse gas emissions, they add.

While some efforts have been made to facilitate the use of drinking water in restaurants and public spaces, and to curb the prevalence of single-use plastics, much more needs to be done, argue the authors.
The reliance on [bottled water] incurs significant health, financial and environmental costs, calling for an urgent re-evaluation of its widespread use.

 Rethinking bottled water in public health discourse, BMJ Global Health (2024). DOI: 10.1136/bmjgh-2024-015226

Part 2

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 9:06am

Bottled water has a huge and growing toll on human and planetary health, experts warn

The huge and growing toll bottled water is taking on human and planetary health warrants an urgent rethink of its use as 1 million bottles are bought every minute around the globe, with that figure set to rise further still amid escalating demand, warn population health experts in a commentary published in the open access journal BMJ Global Health.

Some 2 billion people around the world with limited or no access to safe drinking water rely on bottled water. But for the rest of us, it's largely a matter of convenience and the unshaken belief—aided and abetted by industry marketing—that bottled water is safer and often healthier than tap water.

It isn't, insist the experts!

That's because bottled water often isn't subject to the same rigorous quality and safety standards as tap water, and it can carry the risk of harmful chemicals leaching from the plastic bottles used for it, especially if it's stored for a long time, and/or exposed to sunlight and high temperatures, they explain (the same is true for cold drinks).

Between an estimated 10% and 78% of bottled water samples contain contaminants, including microplastics, often classified as hormone (endocrine) disruptors, and various other substances including phthalates (used to make plastics more durable) and bisphenol A (BPA).

Microplastic contamination is associated with oxidative stress, immune system dysregulation, and changes in blood fat levels. And BPA exposure has been linked to later-life health issues, such as high blood pressure, cardiovascular disease, diabetes and obesity, they add.

Part 1

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 8:50am

Extinct volcanoes a 'rich' source of rare earth elements, research suggests

A mysterious type of iron-rich magma entombed within extinct volcanoes is likely abundant with rare earth elements and could offer a new way to source these in-demand metals, according to new research.

Rare earth elements are found in smartphones, flat screen TVs, magnets, and even trains and missiles. They are also vital to the development of electric vehicles and renewable energy technologies such as wind turbines.

The iron-rich magma that solidified to form some extinct volcanoes is up to a hundred times more efficient at concentrating rare earth metals than the magmas that commonly erupt from active volcanoes.

The findings suggest that these iron-rich extinct volcanoes across the globe, such as El Laco in Chile, could be studied for the presence of rare earth elements." The researchers simulated volcanic eruptions in the lab by sourcing rocks similar to those from iron-rich extinct volcanoes. They put these rocks into a pressurized furnace and heated them to extremely high temperatures to melt them and learn more about the minerals inside the rocks.

This is how they discovered the abundance of rare earth elements contained in iron-rich volcanic rocks. 

Silicate and iron phosphate melt immiscibility promotes REE enrichment, Geochemical Perspectives Letters (2024). DOI: 10.7185/geochemlet.2436

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 8:29am

The scientists created a model for testing smart lighting that aims to keep plants' ability to photosynthesize steady over the course of a day, while still lowering electricity costs. They found that an optimization algorithm could cut electricity costs by 12% without compromising plants' carbon fixation, just by varying the intensity of the light.

They then tested whether varying light intensity affected the growth of leafy plants like spinach which are often grown in vertical farms, and found that there was no negative effect. This remained true even when the plants were subject to irregularly changing light intensity, rather than a predictable, regular pattern.

Vertical farming goes dynamic: optimizing resource use efficiency, product quality, and energy costs, Frontiers in Science (2024). DOI: 10.3389/fsci.2024.1411259

Part 2

Comment by Dr. Krishna Kumari Challa on September 25, 2024 at 8:28am

Indoor vertical farming could future-proof food demand

To make sure everyone eats well in our crowded world, we need to innovate. Vertical farming systems, which grow plants intensively in an indoor setting, could be part of the answer—but to use them on a large scale we need to overcome key problems, especially the management of the energy-intensive, expensive light the plants need to grow.

Now scientists show how manipulating light according to the needs of specific crops could make them grow stronger and healthier while minimizing energy use.

The biggest benefit of vertical farming systems is that healthy food  can be grown much more closely to consumers in places where this is impossible otherwise: in mega-cities, in deserts, and in places that are cold and dark during large parts of the year. But the biggest challenge is the costs associated with electricity use.

  Many vertical farming systems are run using constant environmental conditions, which require lots of expensive electricity for maintenance. The scientists' analysis shows that these demanding conditions are unnecessary: using dynamic environmental control, they suggest, we can achieve vertical farming which is more cost-effective and which raises healthier plants.

Scientists were motivated by the rhythms that plants show on diurnal as well as on developmental timescales, which require their growing environment to be adjusted regularly in order to steer their growth perfectly.

They outlined a strategy that makes use of plant physiology knowledge, novel sensing and modeling techniques, and novel varieties specifically bred for vertical farming systems.

Because plants' biological functions are heavily influenced by environmental conditions like temperature changes, light wavelengths, and the amount of CO₂ in the atmosphere, manipulating the environment allows a vertical farming system to manipulate plant development.

Lighting is a critical variable; all plants need it to photosynthesize, and different light wavelengths have different effects on different plants. This variable is also particularly sensitive to electricity pricing, so offers opportunities to make efficiency gains.

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