Comment

Comment by Dr. Krishna Kumari Challa on September 21, 2024 at 11:01am

Fever drives enhanced activity and mitochondrial damage in a subset of T cells, study finds

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also—in a particular subset of T cells—cause mitochondrial stress, DNA damage and cell death,  researchers have discovered.

The findings, published in the journal Science Immunology, offer a mechanistic understanding of how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.

Researchers' cultured immune system T cells at 39 degrees Celsius (about 102 degrees Fahrenheit). showed  that heat increased helper T cell metabolism, proliferation and inflammatory effector activity and decreased regulatory T cell suppressive capacity.

 The researchers also made an unexpected discovery—that a certain subset of helper T cells, called Th1 cells, developed mitochondrial stress and DNA damage, and some of them died. The finding was confusing, the researchers said, because Th1 cells are involved in settings where there is often fever, like viral infections. Why would the cells that are needed to fight the infection die?

The researchers discovered that only a portion of the Th1 cells die, and that the rest undergo an adaptation, change their mitochondria, and become more resistant to stress.

There's a wave of stress, and some of the cells die, but the ones that adapt and survive are better—they proliferate more and make more cytokine (immune signaling molecules).

Par t1

Comment by Dr. Krishna Kumari Challa on September 21, 2024 at 10:16am

Oceanic life found to be thriving thanks to Saharan dust blown from thousands of kilometers away

Iron is a micronutrient indispensable for life, enabling processes such as respiration, photosynthesis, and DNA synthesis. Iron availability is often a limiting resource in today's oceans, which means that increasing the flow of iron into them can increase the amount of carbon fixed by phytoplankton, with consequences for the global climate.

Iron ends up in oceans and terrestrial ecosystems through rivers, melting glaciers, hydrothermal activity, and especially wind. But not all its chemical forms are "bioreactive," that is, available for organisms to take up from their environment.

Researchers have now shown that iron bound to dust from the Sahara blown westward over the Atlantic has properties that change with the distance traveled: the greater this distance, the more bioreactive the iron.

This relationship suggests that chemical processes in the atmosphere convert less bioreactive iron to more accessible forms.

 The results suggest that during long distance atmospheric transport, the mineral properties of originally non-bioreactive dust-bound iron change, making it more bioreactive. This iron then gets taken up by phytoplankton, before it can reach the bottom of the oceans.

The researchers conclude that dust that reaches regions like the Amazonian basin and the Bahamas may contain iron that is particularly soluble and available to life, thanks to the great distance from North Africa, and thus a longer exposure to atmospheric chemical processes.

The transported iron seems to be stimulating biological processes much in the same way that iron fertilization can impact life in the oceans and on continents. This study is a proof of concept confirming that iron-bound dust can have a major impact on life at vast distances from its source.

 Long-range transport of dust enhances oceanic iron bioavailability, Frontiers in Marine Science (2024). DOI: 10.3389/fmars.2024.1428621. www.frontiersin.org/journals/m … rs.2024.1428621/full

Comment by Dr. Krishna Kumari Challa on September 21, 2024 at 10:05am

Anti-vaxxers: Even ants take precautions. Why can't some human beings?

Black garden ants modify the structure of their nests to mitigate fungal infection spread

A small team of biologists  has found that black garden ants modify the physical structure of their nests to mitigate infection spread. The group has written a paper describing the experiments they conducted with black garden ants and fungal infections in their lab and posted it on the bioRxiv preprint server.

Prior research has shown that some animals change their behaviour to avoid spreading infections, whether they be viral, bacterial or fungal. Among those, only humans have been found to alter their surroundings as a way to further protect themselves— smart people might close off parts of their house, for example, or establish quarantine zones within hospital areas.

In this new study, the research team found an instance of an insect altering its nest to deter the spread of an infecting fungus.

To learn more about how insects, such as ants, attempt to prevent the spread of an infection among members of a nest, the research team went into the field and collected black garden ants—enough to set up 20 colonies in their lab, each in its own glass enclosure. After giving the ants a single day to acclimate themselves to their new environment, the researchers added 20 more ants to each colony—half of which were infected with a fungus known to spread among the ants. The research team then set up cameras to record the behavior of the ants and micro-CT scanners to study the nature of the nest tunnels that the ants dug beneath the soil.

The team found that in the colonies with the infected ants, new tunnels were dug faster than in those not infected. After six days, the spacing between the tunnels was farther apart in the infected nest as well.

The ants in the exposed colonies also placed their queen, food and brooding area in a less central location. And finally, those ants that were infected tended to spend most of their time on the surface, rather than underground with their nestmates.

The researchers next used disease transmission simulations to speed up the process of disease spread and found that the techniques used by the ants did indeed reduce the fungal load in the colony, helping the nest survive.

Luke Leckie et al, Architectural Immunity: ants alter their nest networks to fight epidemics, bioRxiv (2024). DOI: 10.1101/2024.08.30.610481. www.biorxiv.org/content/10.110 … /2024.08.30.610481v1

Comment by Dr. Krishna Kumari Challa on September 21, 2024 at 9:40am

Why communication is becoming difficult: 

Harassment and  Intimidation

Intimidation and harassment have become an occupational hazard for scholars studying phenomena linked to politics, including climate change, disinformation and virology. Now, researchers have united to create a defence playbook that offers tactics for dealing with this reality. Their message is clear: scientists can take steps to protect themselves, but their institutions also need to have a support plan in place.

Climate scientists have been grappling with harassment and threats over their work for more than a decade. In recent years, however, attacks have spread more widely, to biomedical researchers and social scientists. For instance, in 2021 Nature surveyed 300 scientists who had given media interviews about the COVID-19 pandemic and found that two-thirds of respondents had negative experiences because of their public interactions; 22% had received threats of physical or sexual violence. And within the past two years, researchers who study the spread of election and vaccine misinformation on social media have been at the centre of US congressional investigations and laws....

The consortium’s advice for researchers who think they are at risk starts with simple steps such as removing personal contact information and office locations from publicly available websites. But the organization also points to more sophisticated strategies, such as applying for a ‘Certificate of Confidentiality’.

Now should science communicators use incognito mode?
No, I won’t. Even If I get death threats like it happened before.
Why should we be afraid of these morons?

https://www.nature.com/articles/d41586-024-03104-y

Comment by Dr. Krishna Kumari Challa on September 21, 2024 at 8:29am

Symmetry in nature: 

there is symmetry in nature, especially in Biology, and it's present in many forms:

• Animals: The right and left halves of butterflies and elephants are mirror images of each other.
• Flowers: The petals of flowers repeat in a pattern.
• Starfish: The arms of starfish repeat around a central point.
• Leaves: Plant leaves are considered symmetrical, but they rarely match up exactly when folded in half.
• Proteins and RNA: The structures of these tiny things exhibit symmetry.
• Snowflakes: Snowflakes are symmetrical.
• Sunflowers: Sunflowers are symmetrical.

Some scientists believe that nature prefers symmetry and simplicity. For example, a simulation of 13,079,255 different possible protein cluster shapes found that only five had the symmetry of a square.

Symmetry is important in biology, and is used to define and classify groups of animals. For example, animals with radial symmetry are classified as Radiata, and animals with embryonic bilateral symmetry are classified as Bilateria.

And AI told me this: ( I am not a physicist and therefore, cannot confirm or deny this)

Symmetry is an important concept in physics that helps us understand the universe and matter:

Definition

Symmetry is how particles behave when space, time, or quantum numbers are reversed. It can also refer to changes in the mathematical descriptions of nature.

Types

There are three types of symmetry: charge (C), parity (P), and time (T).

Importance

Symmetry is important for understanding the physical properties of matter and the universe. It also helps derive the general theory of relativity and quantum mechanics.

Applications

Symmetry is used in particle physics to derive conservation laws and determine which particle interactions can occur. It's also used to classify crystals and define types of entities.

Symmetry breaking

Symmetry can be exact, approximate, or broken. Exact symmetry is always valid, while approximate symmetry is only valid under certain conditions. Broken symmetry can have different meanings depending on the object and its context.

Comment by Dr. Krishna Kumari Challa on September 20, 2024 at 10:20am

Comment by Dr. Krishna Kumari Challa on September 20, 2024 at 9:41am

Human genome stored on 'everlasting' memory crystal

Scientists have stored the full human genome on a 5D memory crystal—a revolutionary data storage format that can survive for billions of years.

 They hope that the crystal could provide a blueprint to bring humanity back from extinction thousands, millions or even billions of years into the future, should science allow.

The technology could also be used to create an enduring record of the genomes of endangered plant and animal species faced with extinction.

The 5D memory crystal was developed by the University of Southampton's Optoelectronics Research Center (ORC).

Unlike other data storage formats that degrade over time, 5D memory crystals can store up to 360 terabytes of information (in the largest size) without loss for billions of years, even at high temperatures. It holds the Guinness World Record (awarded in 2014) for the most durable data storage material.

The crystal is equivalent to fused quartz, one of the most chemically and thermally durable materials on Earth. It can withstand the high and low extremes of freezing, fire and temperatures of up to 1,000°C. The crystal can also withstand direct impact force of up to 10 tons per cm² and is unchanged by long exposure to cosmic radiation.

The longevity of the crystals means they will outlast humans and other species.

The crystal is stored in the Memory of Mankind archive—a special time capsule within a salt cave in Hallstatt, Austria.

Comment by Dr. Krishna Kumari Challa on September 20, 2024 at 9:33am

The mystery of human wrinkles

A research team successfully recreated the structure of wrinkles in biological tissue in vitro, uncovering the mechanisms behind their formation. Their findings were published on August 19 in the journal Nature Communications.

While wrinkles are often associated with skin aging, many organs and tissues, including the brain, stomach, and intestines, also have distinct wrinkle patterns. These structures play a key role in regulating cellular states and differentiation, contributing to the physiological functions of each organ.

Understanding how biological tissues fold and form wrinkles is vital for understanding the complexity of living organisms beyond cosmetic concerns. This knowledge can be central to advancing research in areas such as skin aging, regenerative therapies, and embryology.

Researchers tried  to replicate both the hierarchical deformation of a single deep wrinkle caused by a strong compressive force and the formation of numerous small wrinkles under lighter compression.

In the process the team also discovered that factors such as the porous structure of the underlying ECM, dehydration, and the compressive force applied to the epithelial layer are crucial to the wrinkle formation process. Their experiments revealed that compressive forces deforming the epithelial cell layer caused mechanical instability within the ECM layer, resulting in the formation of wrinkles.

Additionally, they found that dehydration of the ECM layer was a key factor in the wrinkle formation process. These observations closely mirrored the effects seen in aging skin where dehydration of the underlying tissue layer leads to wrinkle development, providing a mechanobiological model for understanding wrinkle formation.

 Jaeseung Youn et al, Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition, Nature Communications (2024). DOI: 10.1038/s41467-024-51437-z

Comment by Dr. Krishna Kumari Challa on September 20, 2024 at 8:49am

It's not just surprising to find this activity in the SC; it could mean something about why this brain region is being recruited to solve such complex tasks. Since it is present across all vertebrates, from primitive sharks to modern humans, it was one of the earliest brain regions that evolved to help process visual inputs and generate corresponding movements.

But in this new study, it's also involved in decidedly non-spatial functions. Could this be a sign that spatial processing provides a special "oomph" to problem-solving?

The researchers pointed out the kind of eye movements and hand gestures that humans make when we're asked to recall something or make decisions. If someone asks what you had for dinner last night, for example, your eyes often drift upward, as if the answer were written on the ceiling. Or when weighing a decision between two choices, you might move your hands up and down like two sides of a balance scale.
Some of this data might be telling us is that the reason we're making these kinds of spatial gestures and eye movements is because the spatial parts of the brain are getting recruited into helping us perform these non-spatial cognitive functions,
We've all had the experience of struggling to understand something written in text—like a long press release about a neuroscience study—but having it instantly click into place when the same information is presented in a graphic.
They say a picture is worth 1,000 words—even a very simple spatial diagram can rapidly convey so much more information than you can possibly describe. It's like the brain has created this beautiful mental graph paper which it can use to solve both spatial and non-spatial problems.

 Barbara Peysakhovich et al, Primate superior colliculus is causally engaged in abstract higher-order cognition, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01744-x

Part 2

**

Comment by Dr. Krishna Kumari Challa on September 20, 2024 at 8:46am

Brain region that controls eye movements found to also play important role in higher cognitive functions

The superior colliculus is a midbrain region that is traditionally thought to help animals orient themselves toward important locations in space, like directing their eyes and head toward a bright flash of light. New research shows that this part of the brain also plays a role in complex cognitive tasks like visual categorization and decision making.

In the study, published in Nature Neuroscience, scientists measured the information contained in patterns of brain cell activity across multiple brain regions involved in visual category decisions. The researchers monitored activity in the superior colliculus (SC) and part of the posterior parietal cortex (PPC), a region of the cerebral cortex that is important for visual categorical decisions.

The researchers saw that activity in the SC was even more involved than the PPC in guiding the subjects' category decisions, suggesting that it helps coordinate higher-order cognitive processes traditionally thought to take place in the neocortex.

This evolutionarily ancient brain structure that seems to be even more involved in complex cognitive decisions than the cortical areas the researchers studied in their experiments.

All animals, from fish and reptiles to mammals like primates and humans, need to quickly distinguish and categorize objects in their field of vision. Is the object moving toward them an obstacle or a threat? Is that thing darting by a predator or prey?

The SC is a region in the brain that is evolutionarily conserved across all vertebrates, even those without a more sophisticated neocortex. It helps orient movements of the head and eyes toward visual stimuli, and it was traditionally believed to kick off reflexive motor actions by relaying inputs from upstream brain regions.

However, recent research has shown that it is also involved in complex tasks like selecting an orientation point and paying attention to stimuli at different spatial locations.

Part 1

• ‹ Previous
• 1
• …
• 57
• 58
• 59
• 60
• 61
• …
• 998
• Next ›
• Page