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Comment by Dr. Krishna Kumari Challa on August 12, 2021 at 10:30am

A glucose-COVID-19 hypothesis

In normal conditions, the lungs have the necessary immune defense to contain SARS-CoV-2 and avoid spread of the infection. If elevated, glucose impairs this primary defense system making ideal conditions for the SARS-CoV-2 to invade the pulmonary cells and spread into the rest of the body.

Comment by Dr. Krishna Kumari Challa on August 12, 2021 at 10:23am

Lichens may one day detoxify the air in your home

When smoke from fires darken the skies as they did last summer, hunkering down indoors makes good sense. But on most days throughout the year, the air we breathe indoors carries far more pollutants than outdoor air. Exposure is highest in crowded homes where space is a luxury, leading the EPA to rank indoor air quality as one of the top five public health concerns.

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Skull birth defect detailed in cell-by-cell description

Contrary to the popular song, the neck bone is actually connected to one of 22 separate head bones that make up the human skull. These plate-like bones intersect at specialized joints called sutures, which normally allow the skull to expand as the brain grows, but are absent in children with a birth defect called craniosynostosis. A new study in Nature Communications presents a detailed cellular atlas of the developing coronal suture, the one most commonly fused as a consequence of single gene mutations. 

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Humans will always have oxygen to breathe, but we can't say the sam...

There is nothing more fundamental to humans than the availability of oxygen. We give little thought to the oxygen we need, we just breathe, but where does it come from?

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Study says 'blue hydrogen' likely bad for climate

Use of "clean" hydrogen has been seen as a viable and environmentally benign energy alternative, but a study released Thursday said it could lead to higher greenhouse gas emissions than coal.

Touted as clean, 'blue' hydrogen may be worse than gas, coal

"Blue" hydrogen—an energy source that involves a process for making hydrogen by using methane in natural gas—is being lauded as a clean, green energy to help reduce global warming. But Cornell and Stanford University researchers believe it may harm the climate more than burning fossil fuel.

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Is your mobile provider tracking your location? This new technology...

Right now, there is a good chance your phone is tracking your location—even with GPS services turned off. That's because, to receive service, our phones reveal personal identifiers to cell towers owned by major network operators. This has led to vast and largely unregulated data-harvesting industries based around selling users' location data to third parties without consent.

Comment by Dr. Krishna Kumari Challa on August 12, 2021 at 10:19am

Chameleon robot: 

Soft robot chameleon changes color in real-time to match background

Hyeonseok Kim et al, Biomimetic chameleon soft robot with artificial crypsis and disruptive coloration skin, Nature Communications (2021). DOI: 10.1038/s41467-021-24916-w

https://techxplore.com/news/2021-08-soft-robot-chameleon-real-time-...

Comment by Dr. Krishna Kumari Challa on August 11, 2021 at 12:31pm

Innovative coating for blood vessels reduces rejection of transplanted organs
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted.

The polymer, developed by UBC medicine professor Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute, substantially diminished rejection of transplants in mice when tested by collaborators at SFU and Northwestern University.
The findings were published in Nature Biomedical Engineering.

The discovery has the potential to eliminate the need for drugs—typically with serious side effects—on which transplant recipients rely to prevent their immune systems from attacking a new organ as a foreign object.

Blood vessels in our organs are protected with a coating of special types of sugars that suppress the immune system’s reaction, but in the process of procuring organs for transplantation, these sugars are damaged and no longer able to transmit their message.

Researchers now  synthesized a polymer to mimic these sugars and developed a chemical process for applying it to the blood vessels. This new technology  prevented rejection in the studies.

The procedure has been applied only to blood vessels and kidneys in mice so far. Clinical trials in humans could still be several years away. Still, the researchers are optimistic it could work equally well on lungs, hearts and other organs, which would be great news for prospective recipients of donated organs.

1. Erika M. J. Siren, Haiming D. Luo, Franklin Tam, Ashani Montgomery, Winnie Enns, Haisle Moon, Lyann Sim, Kevin Rey, Qiunong Guan, Jiao-Jing Wang, Christine M. Wardell, Mahdis Monajemi, Majid Mojibian, Megan K. Levings, Zheng J. Zhang, Caigan Du, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu. Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers. Nature Biomedical Engineering, 2021; DOI: 10.1038/s41551-021-00777-y

https://researchnews.cc/news/8271/Innovative-coating-for-blood-vess...

Comment by Dr. Krishna Kumari Challa on August 11, 2021 at 12:21pm

In the complementary bladder-on-chip model, the researchers looked at the growth dynamics of bacteria within intracellular bacterial communities over time. They grew human umbrella and endothelial cells together under a simulated urine-flow system, and applied mechanical stresses to mimic the natural expansion and contraction of the bladder. This study focused on the role of neutrophil recruitment in response to infection, revealing that neutrophils cannot eliminate intracellular bacterial communities. By tracking intracellular bacterial communities over successive cycles of antibiotic treatment, the researchers found them to be highly dynamic and resistant to antibiotics. “These studies are part of the NCCR-funded “AntiResist” consortium aimed at developing more realistic in vitro models for infectious diseases, and using this knowledge to develop optimal treatment strategies, which could potentially have an enormous impact on human health,” says McKinney. “Microphysiological models bridge the gap between simple cell culture systems and animal models,” says Vivek V. Thacker, a senior author on both studies. “The two models complement each other well and are tailored to study specific aspects of the disease. We hope they will serve as a resource for the wider microbiology community and advance the synergies between the tissue engineering and infectious diseases communities.” https://researchnews.cc/news/8264/Organoid-bladders-reveal-secrets-... part3

Comment by Dr. Krishna Kumari Challa on August 11, 2021 at 12:20pm

To address this, the group of Professor John McKinney at EPFL’s School of Life Sciences developed two complementary bladder models to study UTIs in a more controlled way. The first model consists of bladder organoids that recreate the 3D stratified architecture of the bladder epithelium. Organoids are tiny lab-grown tissues and organs that are anatomically correct and physiologically functional.

The second model is a bladder-on-a-chip that incorporates physiological stimuli, e.g. the mechanical effect of bladder filling and voiding, as well as an interface with the vasculature to study immune cell migration to sites of infection. The advances were published in the journals Cell Reports and eLife.

“By generating organoids from a mouse with a fluorescent label incorporated within cell membranes, we could use live-cell confocal imaging at EPFL’s BioImaging & Optics Core Facility to identify specific bacterial niches within the organoid with a high spatial resolution,” says Sharma. “By imaging multiple organoids, we managed to identify heterogeneity and diverse outcomes of host-pathogen interactions. This proof-of-concept system has shown promising potential for follow up studies on bacterial persistence to antibiotics and the dynamics of immune cell responses to infection.”

In combination with volumetric electron microscopy performed by EPFL’s Biological Electron Microscopy Facility, the researchers found that solitary bacteria rapidly invade into deeper layers of the bladder, independently of the formation of intracellular bacterial communities, where they are protected from antibiotics and host immune cells. These findings could be leveraged to improve UTI treatment strategies.

part 2

Comment by Dr. Krishna Kumari Challa on August 11, 2021 at 12:20pm

Organoid bladders reveal secrets of UTIs

Urinary tract infections (UTIs) are among the most common bacterial infections. They usually require treatment with antibiotics, and almost a quarter of treated cases lead to recurrent infection. The vast majority of UTIs are caused by a subspecies of the bacterium Escherichia coli, which infect cells that line the bladder wall and form what are known as “intracellular bacterial communities”.

The “communities” repeatedly rupture and bacteria re-enter neighboring cells, eventually killing off the so-called “umbrella cells” that line the outermost layer of the bladder’s epithelium. The loss of umbrella cells then allows the bacteria to invade the deeper layers of the bladder, where they can form “quiescent intracellular reservoirs” that are resistant to antibiotics and cause UTI recurrences. The dynamics of these events are hard to capture in vivo in animal models.

“Infection dynamics are difficult to capture from static imaging of tissue explants at serial time points,” says Kunal Sharma, the lead author on the two studies. “Thus far, in vitro models have not recapitulated bladder architecture with sufficient fidelity to study the time course of these events.”

Part 1

Comment by Dr. Krishna Kumari Challa on August 11, 2021 at 10:29am

Middle-age height loss linked to heightened death risk in northern European women

Height loss in middle age is linked to a heightened risk of early death, primarily from heart disease or stroke—at least in Northern European women—suggests research published in the online journal BMJ Open.

But regular physical activity may help to stave off mid-life shrinkage, as well as lowering cardiovascular disease risk, the findings indicate.

People tend to start losing height once they reach their 50s, a process that speeds up during their 70s. Height loss is usually caused by vertebral disc shrinkage, spinal compression fractures, and changes in posture.

While some degree of height loss is associated with natural aging, previous research suggests that it may also be associated with an increased risk of death from heart disease.

In the study, each cm of height loss was associated with 14% and 21% greater odds of death from any cause among the Swedish and Danish women, respectively, after adjusting for potentially influential factors.

Short stature and high leisure time physical activity (including participation in competitive sports) at study entry were associated with less height loss, independent of age.

Major height loss, defined as more than 2 cm, was associated with 74% and 80% greater odds of death, respectively, among two groups of women.

Other unmeasured factors may also have influenced the findings, they add. These include early life physical activity and exposure to tobacco (either through second-hand smoke or smoking themselves], peak bone mass, underlying health conditions and medical treatments.

Nevertheless, the findings prompt the researchers to conclude that mid-life height loss "is a risk marker for earlier mortality in northern European women."

Specifically, the risk of cardiovascular disease is increased in women who lose height, with death from stroke a major contributor to this association, they add.

 Loss of height predicts total and cardiovascular mortality: a cohort study of northern European women, BMJ Open (2021). DOI: 10.1136/bmjopen-2021-049122

https://medicalxpress.com/news/2021-08-middle-age-height-loss-linke...

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Comment by Dr. Krishna Kumari Challa on August 10, 2021 at 11:16am

Comment by Dr. Krishna Kumari Challa on August 10, 2021 at 9:13am

'It's not climate change, it's climate chaos', wars UN | UN Climate report 2021

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