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Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 8:05am

Quantum collaboration gives new gravity to the mysteries of the universe

Scientists have used cutting-edge research in quantum computation and quantum technology to pioneer a radical new approach to determining how our Universe works at its most fundamental level.

An international team of experts have demonstrated that only quantum and not classical gravity could be used to create a certain informatic ingredient that is needed for quantum computation. Their research "Non-Gaussianity as a signature of a quantum theory of gravity" has been published recently in PRX Quantum.

For more than a hundred years, physicists have struggled to determine how the two foundational theories of science, quantum theoryand general relativity, which respectively describe microscopic and macroscopic phenomena, are unified into a single overarching theory of nature.

During this time, they have come up with two fundamentally contrasting approaches, called 'quantum gravity' and 'classical gravity'. However, a complete lack of experimental evidence means that physicists do not know which approach the overarching theory actually takes, our research provides an experimental approach to solving this.

This new research, which is a collaboration between experts in quantum computing, quantum gravity, and quantum experiments finds an unexpected connection between the fields of quantum computing and quantum gravity and uses this to propose a way to test experimentally that there is quantum not classical gravity. The suggested experiment would involve cooling billions of atoms in a millimeter-sized spherical trap to extremely low temperatures such that they enter a new phase of matter, called a Bose-Einstein condensate, and start to behave like a single large, quantum atom. A magnetic field is then applied to this "atom" so that it feels only its own gravitational pull. With this all in place, if the single gravitating atom demonstrates the key ingredient needed for quantum computation, which is curiously associated with "negative probability," nature must take the quantum gravity approach.

This proposed experiment uses current technology, involves just a single quantum system, the gravitating "atom," and does not rely on assumptions concerning the locality of the interaction, making it simpler than previous approaches and potentially expediating the delivery of the first experimental test of quantum gravity. Physicists would then, after more than a hundred years of research, finally have information on the true overarching, fundamental theory of nature.

Richard Howl et al, Non-Gaussianity as a Signature of a Quantum Theory of Gravity, PRX Quantum 2, 010325 – Published 17 February 2021, DOI: 10.1103/PRXQuantum.2.010325

https://phys.org/news/2021-02-quantum-collaboration-gravity-mysteri...

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Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 7:24am

An mRNA vaccine for cancer immunotherapy

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Now, researchers reporting in ACS' Nano Letters have developed a hydrogel that, when injected into mice with melanoma, slowly released RNA nanovaccines that shrank tumors and kept them from metastasizing.

Cancer immunotherapy vaccines work similarly to mRNA vaccines for COVID-19, except they activate the immune system to attack tumors instead of a virus. These vaccines contain mRNA that encodes proteins made specifically by tumor cells. When the mRNA enters antigen-presenting cells, they begin making the tumor protein and displaying it on their surfaces, triggering other immune cells to seek and destroy tumors that also make this protein. However, mRNA is an unstable molecule that is quickly degraded by enzymes in the body. For cancer immunotherapy, researchers have tried using nanoparticles to protect and deliver mRNA, but they are typically cleared from the body within 1-2 days after injection. Researchers wanted to develop a hydrogel that, when injected under the skin, would slowly release mRNA nanoparticles, along with an adjuvant—a molecule that helps activate the immune system.

To develop their system, the researchers used ovalbumin (a protein found in chicken egg whites) as a model antigen. The team mixed ovalbumin mRNA and an adjuvant with other compounds to form a hydrogel. When injected under the skin of mice with melanoma tumors engineered to express ovalbumin, the hydrogel slowly released mRNA and adjuvant nanoparticles over a 30-day period. The mRNA vaccine activated T cells and stimulated antibody production, causing tumors to shrink in the treated mice. Also, in contrast to untreated mice, the vaccinated mice did not show any metastasis to the lung.

These results demonstrate that the hydrogel has great potential for achieving long-lasting and efficient cancer immunotherapy with only a single treatment, the researchers say.

"In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy" Nano Letters (2021). pubs.acs.org/doi/abs/10.1021/acs.nanolett.0c05039

https://phys.org/news/2021-02-mrna-vaccine-cancer-immunotherapy.htm...

Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 7:20am

Researchers report switching material between semiconductor and met...

A group of researchers from the Fritz Haber Institute of the Max Planck Society and the Humboldt-Universität zu Berlin have found out that a semiconductor can be converted to a metal and back by light more easily and more quickly than previously thought. This discovery may increase the processing speed and simplify the design of many common technological devices.

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Making swimming pools safer by reducing chlorine disinfection bypro...

Swimming in indoor or outdoor pools is a healthy form of exercise and recreation for many people. However, studies have linked compounds that arise from chlorine disinfection of the pools to respiratory problems, including asthma, in avid swimmers. Now, researchers reporting in ACS' Environmental Science & Technology have found that using a complementary form of disinfection, known as copper-silver ionization (CSI), can decrease disinfection byproducts and cell toxicity of chlorinated swimming pool water.

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Evidence of Planet Nine diminishing as researchers find no evidence...

An international team of researchers has found no evidence of trans-Neptunian object clustering as part of an effort to refute the idea of the existence of Planet Nine. The group has written a paper describing their findings and have uploaded it to the arXiv preprint server.

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This is what happens to spacecraft when they re-enter the Earth's a...

When one of the Russian Progress resupply ships undocks from the International Space Station, timing is everything. The Progress needs to fire its engines at just the right time to instigate the deorbit burn in order for the ship to enter the atmosphere at just the right place so that its destructive re-entry occurs over the Pacific Ocean. That way, any potential surviving bits and pieces that might reach Earth will hit far away from any land masses—which are home to people, buildings, and other things we don't want to get bonked.

Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 7:17am

Protein linked to Alzheimer's, strokes cleared from brain blood vessels

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer's dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes.

Several antibodies that target amyloid plaques have been studied as experimental treatments for Alzheimer's disease. Such antibodies also may have the potential to treat cerebral amyloid angiopathy, although they haven't yet been evaluated in clinical trials. But all of the anti-amyloid antibodies that have successfully reduced amyloid plaques in Alzheimer's clinical trials also can cause a worrisome side effect: an increased risk of brain swelling and bleeds.

Now, researchers at Washington University School of Medicine in St. Louis have identified an antibody that, in mice, removes amyloid plaques from brain tissue and blood vessels without increasing risk of brain bleeds. The antibody targets a minor component of amyloid plaques known as apolipoprotein E (APOE).

The findings, published Feb. 17 in Science Translational Medicine, suggest a potentially safer approach to removing harmful amyloid plaques as a way of treating Alzheimer's disease and cerebral amyloid angiopathy.

 "APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function" Science Translational Medicine (2021). stm.sciencemag.org/lookup/doi/ … scitranslmed.abd7522

https://medicalxpress.com/news/2021-02-protein-linked-alzheimer-bra...

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Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 7:09am

New skin patch brings us closer to wearable, all-in-one health monitor

Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 7:07am

A disease-sniffing device that rivals a dog's nose

Numerous studies have shown that trained dogs can detect many kinds of disease—including lung, breast, ovarian, bladder, and prostate cancers, and possibly COVID-19—simply through smell. In some cases, involving prostate cancer for example, the dogs had a 99 percent success rate in detecting the disease by sniffing patients' urine samples.

But it takes time to train such dogs, and their availability and time is limited. Scientists have been hunting for ways of automating the amazing olfactory capabilities of the canine nose and brain, in a compact device. Now, a team of researchers at MIT and other institutions has come up with a system that can detect the chemical and microbial content of an air sample with even greater sensitivity than a dog's nose. They coupled this to a machine-learning process that can identify the distinctive characteristics of the disease-bearing samples.

The findings, which the researchers say could someday lead to an automated odor-detection system small enough to be incorporated into a cellphone, are being published recently in the journal PLoS ONE.

Guest C, Harris R, Sfanos KS, Shrestha E, Partin AW, Trock B, et al. (2021) Feasibility of integrating canine olfaction with chemical and microbial profiling of urine to detect lethal prostate cancer. PLoS ONE 16(2): e0245530. doi.org/10.1371/journal.pone.0245530

https://phys.org/news/2021-02-disease-sniffing-device-rivals-dog-no...

Comment by Dr. Krishna Kumari Challa on February 18, 2021 at 6:55am

A 'twisted elevator' could be key to understanding neurological diseases

A University of Sydney-led international team of scientists has revealed the shape of one of the most important molecular machines in our cellsthe glutamate transporter, helping to explain how our brain cells communicate with one another.

Glutamate transporters are tiny proteins on the surface of all our cells that shut on and off the chemical signals that have a big role in making sure all cell-to-cell talk runs smoothly. They are also involved in nerve signalling, metabolism and learning and memory.

The researchers captured the transporters in exquisite detail using cryogenic electron microscopy (cryo-EM), showing they look like a 'twisted elevator' embedded in the cell membrane.

This world-first discovery opens a whole new field of possibility, studying if defects in the transporters could be the reason behind neurological diseases such as Alzheimer's disease.

The results of the research have been published in Nature.

Using Cryo-EM,researchers have uncovered for the first time just how these transporters can multitask—carrying out the dual functions of moving chemicals (like glutamate) across the cell membrane while also allowing water and chloride ions to move through at the same time. These molecular machines use a really cool twisting, elevator-like mechanism to move their cargo across the cell membrane. But they also have an additional function where they can allow water and chloride ions to move across the cell membrane.

Understanding how the molecular machines in our cells work enables us to interpret defects in these machines in disease states and also gives us clues as to how we might target these machines with therapeutics.

Mapping out in detail the structure of the glutamate transporter could be a crucial tool for researchers in understanding how our bodies work ,and the mechanism behind some diseases.

Defects in the glutamate transporter have been linked to many neurological diseases such as Alzheimer's disease and stroke.

This includes rare diseases such as episodic ataxia, a disease that impacts movement and causes periodic paralysis, caused by an uncontrolled leak of chloride through the glutamate transporter in brain cells.

Glutamate transporters have a chloride channel with two hydrophobic gates, Nature (2021). DOI: 10.1038/s41586-021-03240-9 , dx.doi.org/10.1038/s41586-021-03240-9

https://phys.org/news/2021-02-elevator-key-neurological-diseases.ht...

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Comment by Dr. Krishna Kumari Challa on February 17, 2021 at 9:49am

Lunar Pioneers Will Use Lasers to Phone Home

NASA’s Orion and Gateway will try out optical communications gear for a high-speed connection to Earth

To meet the demands of high-definition video and data-intensive scientific research, NASA and other space agencies are pushing the radio bands traditionally allocated for space research to their limits. For example, the Orion spacecraft, which will carry astronauts around the moon during NASA’s Artemis 2 mission in 2022, will transmit mission-critical information to Earth via an S-band radio at 2 megabits per second. “It’s the most complex flight-management system ever flown on a spacecraft.

To boost data rates even higher means moving beyond radio and developing optical communications systems that use lasers to beam data across space. In addition to its S-band radio, Orion will carry a laser communications system for sending ultrahigh-definition 4K video back to Earth. And further out, NASA’s Gateway will create a long-term laser communications hub linking our planet and its satellite.

Laser communications are a tricky proposition. The slightest jolt to a spacecraft could send a laser beam wildly off course, while a passing cloud could interrupt it. But if they work, robust optical communications will allow future missions to receive software updates in minutes, not days. Astronauts will be sheltered from the loneliness of working in space. And the scientific community will have access to an unprecedented flow of data between Earth and the moon.

https://spectrum.ieee.org/telecom/wireless/lunar-pioneers-will-use-...

Comment by Dr. Krishna Kumari Challa on February 17, 2021 at 9:28am

The Colossal Weight of Cities Is Making Them Sink, Even as Sea Levels Are Rising

Cities don't just have sea level rises to worry about – they're also slowly sinking under the weight of their own development, according to new research, which emphasises the importance of factoring subsidence into models of climate change risk.

As global populations move disproportionately toward the coasts, this additional subsidence in combination with expected sea level rise may exacerbate risk associated with inundation.

Anthropogenic loading effects at tectonically active continental margins are likely greater than more stable continental interiors where the lithosphere tends to be thicker and more rigid.

There are plenty of other causes of subsidence to think about too, including tectonic plate shifting and the groundwater pumping necessary to support a growing population – something we've seen cause significant city sinking in other parts of the world. The findings are notable enough to make city weight another consideration when scientists are figuring out how geography might change over time, and which areas are under threat as the sea level gets higher.

https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2020AV000277

https://www.sciencealert.com/the-weight-of-cities-is-sinking-urban-...

Comment by Dr. Krishna Kumari Challa on February 17, 2021 at 9:21am

'New Car Smell' Is The Scent of Carcinogens, And Even Short Trips May Overexpose Us

A new study found commutes of more than 20 minutes put people at risk of unacceptably high levels of two carcinogens used in car manufacturing.

The distinct smell of a new car gives you a whiff of what's happening here. Materials used to fit out cars, from hard and soft plastics to adhesives, textiles and foam, contain some chemicals that can slowly seep into the air (the technical term is 'off-gas') or catch a ride on dust.

These chemicals are very volatile, moving easily from plastics and textiles to the air that you breathe. Volatile compounds can build up in small spaces, such as inside a car (unless you open a window for fresh air).

The researchers predicted that commuters' daily exposure to two out of five chemicals studied - benzene and formaldehyde - would probably exceed levels considered safe . The likelihood continued to rise the longer a person's commute. 

The two chemicals of concern are not huge unknowns, but certainly warrant attention. Benzene is found in rubber and dyes, and formaldehyde is used in carpets and paints. There is a range of exposure that depends on how long you're in the car, and how much of the compounds your car is emitting which can depend on the vehicle's age and surrounding temperatures.

 just because something is listed as a carcinogen doesn't mean it's guaranteed to cause health problems – it depends on the dose that people are exposed to, and how often.

Even known carcinogens are not likely to cause cancer under certain thresholds, and limiting your exposure to harmful substances goes a long way to reducing any associated risk.

Plus, the poor health outcomes observed among commuters – which does include higher rates of cancer – may stem from a combination of inactivity, obesity and shorter sleep that often come with lengthy commutes. These factors were not considered in this study.  

https://www.sciencedirect.com/science/article/pii/S016041202100026X...

https://www.sciencealert.com/a-20-minute-commute-puts-you-at-risk-o...

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