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Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:37am

Quantum researchers cause controlled 'wobble' in the nucleus of a single atom

Researchers have been able to initiate a controlled movement in the very heart of an atom. They caused the atomic nucleus to interact with one of the electrons in the outermost shells of the atom. This electron could be manipulated and read out through the needle of a scanning tunneling microscope.

The research, published in Nature Communications, offers prospects for storing quantum information inside the nucleus, where it is safe from external disturbances.

Lukas M. Veldman et al, Coherent spin dynamics between electron and nucleus within a single atom, Nature Communications (2024). DOI: 10.1038/s41467-024-52270-0

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:33am

Fluorescent nanomaterial could transform how we visualize fingerprints

Researchers created a fluorescent nanoparticle using a combination of materials (MCM-41, chitosan and dansylglycine) to examine latent fingerprints. These nanoparticles have special properties that make them adhere well to fingerprint residues, even old ones.

The nanoparticles work on various surfaces, including metal, plastic, glass and complex objects such as polymer banknotes. They have the potential to be used directly at crime scenes without lab facilities, which is a significant advantage over some previous reagents. They produce high-quality fingerprint images for successful identification. 

This new method captures the finer details of a fingerprint, making it easier to identify individuals and is expected greatly to aid in forensic investigations. The research was published in a RSC Advances paper, highlighting that the new nanomaterial has proven to be a versatile and effective tool for visualizing fingerprint evidence. Small angle X-ray scattering (SAXS) techniques at Diamond provided useful data to validate these results.

Lais F. A. M. Oliveira et al, Dansyl fluorophore functionalized hierarchically structured mesoporous silica nanoparticles as novel latent fingerprint development agents, RSC Advances (2024). DOI: 10.1039/D4RA03074E

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:30am

 Printing 3D photonic crystals that completely block light

Photonic crystals are materials with repeating internal structures that interact with light in unique ways. We can find natural examples in opals and the vibrant colored shells of some insects. Even though these crystals are made of transparent materials, they exhibit a "photonic bandgap" that blocks light at certain wavelengths and directions.

A special type of this effect is a "complete photonic bandgap," which blocks light from all directions. This complete bandgap allows for precise control of light, opening up possibilities for advancements in telecommunications, sensing, and quantum technologies. As a result, scientists have been working on different methods to create these advanced photonic crystals.

While 1D and 2D photonic crystals have been used in various applications, unlocking the secret to producing 3D photonic crystals with a complete photonic bandgap in the visible range has been fraught with challenges due to the need to achieve nanoscale precise control of all three dimensions in the fabrication process.

This is all set to change. In a study, "Printing of 3D photonic crystals in titania with complete bandgap across the visible spectrum" published in Nature Nanotechnology, researchers across institutions in Singapore and China have achieved an unprecedented feat. Led by Professor Joel Yang from the Singapore University of Technology and Design (SUTD), the team has developed a revolutionary method to print 3D photonic crystals using a customized titanium resin.

Unlike in previous attempts, this new method has resulted in crystals that are of high resolution, possess a high refractive index, and feature a complete bandgap across the range of visible light. The innovation holds immense potential for transforming industries.

Wang Zhang et al, Printing of 3D photonic crystals in titania with complete bandgap across the visible spectrum, Nature Nanotechnology (2024). DOI: 10.1038/s41565-024-01780-5

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:21am

The five factors identified are tumor mutational burden; effective T cell infiltration; the activity of transforming growth factor beta (TGF-β) in the tumor microenvironment; previous treatment received by the patient; and tumor proliferative potential. These factors in different types of cancer are associated with the response to CPIs and have been validated by the authors in six independent cohorts, covering a total of 1,491 patients.

Tumor mutational burden (TMB): Tumors with a high number of mutations tend to produce more neoantigens, making it easier for the immune system to recognize and attack them. TMB has been one of the most studied biomarkers for predicting response to CPIs.
Effective T-cell infiltration: The presence of cytotoxic T-cells in the tumor is essential for the effectiveness of CPIs. This study has confirmed that a higher infiltration of these cells is directly related to a better response to the therapy.
TGF-β activity in the tumor microenvironment: This factor influences the behavior of some cells in the tumor microenvironment. High TGF-β activity can suppress the immune response, which is reflected in a tendency for patients to have poorer survival after immunotherapy treatment.
Previous treatment: Patients who have received previous treatments tend to show a poorer response to immunotherapy.
Tumor proliferative potential: Patients with tumors that have a high proliferative index, which tend to be more aggressive, generally show poorer survival after treatment.
These five factors provide a framework for organizing the vast current knowledge about biomarkers of immunotherapy response.
Furthermore, the researchers demonstrated that a multivariate model combining these five factors allows for more accurate patient classification than using tumor mutational burden alone ( as is frequently done in clinical practice), predicting the probability of patients to respond to immunotherapy.

Five latent factors underlie response to immunotherapy, Nature Genetics (2024). DOI: 10.1038/s41588-024-01899-0

Part 2

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:19am

Five key factors that predict response of cancer patients to immunotherapy

A team of researchers  has identified five independent factors that predict cancer patients' response to checkpoint inhibitors (CPIs). The study, which has been published in Nature Genetics, validates these factors in more than 1,400 patients and diverse types of cancer. These findings provide a framework to interpret biomarkers of response to CPIs and suggest a future pathway to improve personalized cancer medicine.

Immunotherapy has transformed cancer treatment in recent years by enabling the immune system to attack tumor cells. However, only 20–40% of patients respond positively to immunotherapy, and these rates vary across different types of cancer.

Predicting which patients will respond to immunotherapy and which will not is currently a highly active area of research. Numerous studies conducted so far have focused on the specific characteristics of tumors, their microenvironment, or the patient's immune system. As a result, which of the proposed biomarkers represent the same underlying factors or how many independent factors influence the effectiveness of this therapy remains unclear.
Researchers have identified five key, independent factors that determine patients' response and survival after receiving checkpoint inhibitors (CPIs), a type of immunotherapy widely used in cancer treatment. These findings provide a reference framework for current and future biomarkers of immunotherapy response.

They could also, in the future, entail a pathway to a significant advancement in the personalization of cancer treatments, helping to more accurately identify those patients who are likely to benefit from immunotherapy. The results suggest that patients with certain types of tumors who are currently not considered candidates for immunotherapy (such as those with liver or kidney carcinomas) might benefit from this type of treatment.

Part 1

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:16am

Personal carbon footprint of the rich is vastly underestimated by rich and poor alike, study finds

The personal carbon footprint of the richest people in society is grossly underestimated, both by the rich themselves and by those on middle and lower incomes, no matter which country they come from. At the same time, both the rich and the poor drastically overestimate the carbon footprint of the poorest people.

An international group of researchers surveyed 4,000 people from Denmark, India, Nigeria and the United States about inequality in personal carbon footprints—the total amount of greenhouse gases produced by a person's activities—within their own country.

Although it is well-known that there is a large gap between the carbon footprint of the richest and poorest in society, it's been unclear whether individuals were aware of this inequality. The four countries chosen for the survey are all different in terms of wealth, lifestyle and culture. Survey participants also differed in their personal income, with half of participants belonging to the top 10% of income in their country.

The vast majority of participants across the four countries overestimated the average personal carbon footprint of the poorest 50% and underestimated those of the richest 10% and 1%.

However, participants from the top 10% were more likely to support certain climate policies, such as increasing the price of electricity during peak periods, taxing red meat consumption or subsidizing carbon dioxide removal technologies such as carbon capture and storage.

The researchers say that this may reflect generally higher education levels among high earners, a greater ability to absorb price-based policies or a stronger preference for technological solutions to the climate crisis. The results are reported in the journal Nature Climate Change.

Due to their greater financial and political influence, most climate policies reflect the interests of the richest in society and rarely involve fundamental changes to their lifestyles or social status.

Greater awareness and discussion of existing inequality in personal carbon footprints can help build political pressure to address these inequalities and develop climate solutions that work for all, say the researchers. 

Underestimation of personal carbon footprint inequality in four diverse countries, Nature Climate Change (2024). DOI: 10.1038/s41558-024-02130-y

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 9:10am

Ozone pollution reduces yearly tropical forest growth by 5.1%, study finds

Ozone gas is reducing the growth of tropical forests—leaving an estimated 290 million tonnes of carbon uncaptured each year, new research shows.

The ozone layer in the stratosphere shields our planet from harmful ultraviolet radiation—and protecting it is one of the major successes of environmental action.

But ozone at ground level—formed by the combination of pollutants from human activities in the presence of sunlight—interferes with plants' ability to absorb carbon dioxide. Ozone is also harmful to human health.

The new study, published in the journal Nature Geoscience, calculates that ground-level ozone reduces new yearly growth in tropical forests by 5.1% on average.

The effect is stronger in some regions—with Asia's tropical forests losing 10.9% of new growth.

Tropical forests are vital "carbon sinks"—capturing and storing carbon dioxide that would otherwise stay in the atmosphere and contribute to global warming.

Tropical forests play a crucial role in mopping up our carbon dioxide emissions.

This study shows that air pollution can jeopardize this critical ecosystem service.

Urbanization, industrialization, burning fossil fuels and fires have led to an increase in "precursor" molecules—such as nitrogen oxides—that form ozone.

Reduced productivity and carbon drawdown of tropical forests from ground-level ozone exposure, Nature Geoscience (2024). DOI: 10.1038/s41561-024-01530-1

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 8:59am

The global community of Earth scientists started buzzing with online discussion of what could be causing the strange seismic waves. The discussion turned up reports of a huge landslide in a remote Greenland fjord that occurred on Sept. 16, around the time the seismic signal was first detected.

To figure out if and how these two phenomena might be connected, scientists combined seismic recordings from around the world, field measurements, satellite imagery and computer simulations to reconstruct the extraordinary events.

The team, comprised of 68 scientists from 41 research institutions, analyzed satellite and on-the-ground imagery to document the enormous volume of rock and ice in the landslide that triggered the tsunami. They also analyzed the seismic waves to model the dynamics and trajectory of the rock-ice avalanche as it moved down the glacial gully and into the fjord.

To understand the tsunami and resulting seiche, the researchers used supercomputers to create high-resolution simulations of the events.
Ultimately, these simulations were able to closely match the real-world tsunami's height as well as the long-lasting seiche's slow oscillations.

By integrating these diverse data sources, the researchers determined that the nine-day seismic signal was caused by the massive landslide and resulting seiche within Greenland's Dickson Fjord.
The study's findings demonstrate the complex, cascading hazards posed by climate change on Earth.

The essence of science is trying to answer a question we don't know the answer to—that's why this was so exciting to work on, say the scientists who found this.

Kristian Svennevig, A rockslide-generated tsunami in a Greenland fjord rang the Earth for 9 days, Science (2024). DOI: 10.1126/science.adm9247. www.science.org/doi/10.1126/science.adm9247

Part 2

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 8:55am

Climate change-triggered landslide unleashes a 650-foot mega-tsunami

In September 2023, scientists around the world detected a mysterious seismic signal that lasted for nine straight days. An international team of scientists, including seismologists Alice Gabriel and Carl Ebeling of UC San Diego's Scripps Institution of Oceanography came together to solve the mystery.

A study published in Science provides the stunning solution: In an East Greenland fjord, a mountaintop collapsed into the sea and triggered a mega-tsunami about 200 meters (650 feet) tall. The giant wave rocked back and forth inside the narrow fjord for nine days, generating the seismic waves that reverberated through Earth's crust, baffling scientists around the world.

This rhythmic sloshing is a phenomenon known as a seiche. Fortunately, no people were hurt, but the waves destroyed some $200,000 in infrastructure at an unoccupied research station on Ella Island.

Climate change set the stage for the landslide by melting the glacier at the base of the mountain, destabilizing the more than 25 million cubic meters (33 million cubic yards) of rock and ice—enough to fill 10,000 Olympic-sized swimming pools—that ultimately crashed into the sea. As climate change continues to melt Earth's polar regions it could lead to an increase in large, destructive landslides such as this one.

Climate change is shifting what is typical on Earth, and it can set unusual events like this into motion.

When seismic monitoring networks first detected this signal in September 2023, it was puzzling for two main reasons. First, the signal looked nothing like the busy squiggle that earthquakes produce on seismographs. Instead, it oscillated with a 92-second-interval between its peaks, too slow for humans to perceive. Second, the signal stayed strong for days on end, where more common seismic events weaken more rapidly.

Part 1

Comment by Dr. Krishna Kumari Challa on September 13, 2024 at 8:50am

Smart mouthguard allows users to control devices with their tongue and teeth

Recent technological advances have enabled the development of a wide range of electronic devices designed to improve people's quality of life and assist them in completing their everyday activities. Most existing devices are operated via touch screens, keyboards, mouse pads and other hand-based interfaces.

Researchers at the National University of Singapore have developed a smart mouthguard that could allow people to operate their devices using their mouth, instead of their fingers. This new device, introduced in a paper in Nature Electronics, could also allow dentists to collect medical data from inside their patients' mouths and help to monitor the recovery of athletes or enhance their performance.

Bo Hou et al, A tactile oral pad based on carbon nanotubes for multimodal haptic interaction, Nature Electronics (2024). DOI: 10.1038/s41928-024-01234-9.

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