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Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:47am

New optical method paves way to breath test for cancer biomarker

Researchers have developed an extremely sensitive, yet simple optical method for detecting formaldehyde in a person's breath. Because formaldehyde is being studied as a potential biomarker for lung and breast cancer, the new method could one day lead to an inexpensive and fast way to screen for cancer.

Measuring biomarkers in exhaled breath is noninvasive, painless and fast and could be used to screen for cancer even at very early disease stages, which is crucial for successful treatment.

This new optical sensing method based on multipass spectroscopy can detect the presence of 1 molecule of formaldehyde in a million air particles, or 1 part per million, even in the presence of gasses that can interfere with optical measurement.

Mateusz Winkowski et al, Optical detection of formaldehyde in air in the 36 µm range, Biomedical Optics Express (2020). DOI: 10.1364/BOE.405384

https://phys.org/news/2020-11-optical-method-paves-cancer-biomarker...

Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:36am

 Math shows diverse thinkers equal better results

The exchange of information is key in making everyday decisions. But new  research shows that the group decision-making process may work best when members process information a bit differently.

Researchers published a new study today that tackles how groups make decisions and the dynamics that make for fast and accurate decision making. They found that networks that consisted of both impulsive and deliberate individuals made, on average, quicker and better decisions than a group with homogenous thinkers.

Bhargav Karamched et al. Heterogeneity Improves Speed and Accuracy in Social Networks, Physical Review Letters (2020). DOI: 10.1103/PhysRevLett.125.218302

https://phys.org/news/2020-11-decision-math-diverse-thinkers-equal....

Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:30am

Excess consumption of eggs linked to diabetes

The health benefits of the humble egg might not be all they're cracked up to be as new research from the University of South Australia shows that excess egg consumption can increase your risk of diabetes. It found that people who regularly consumed one or more eggs per day (equivalent to 50 grams) increased their risk of diabetes by 60 percent.

It was discovered  that higher long-term egg consumption (greater than 38 grams per day) increased the risk of diabetes among Chinese adults by approximately 25 percent.

The effect was also more pronounced in women than in men.

Yue Wang et al, Higher egg consumption associated with increased risk of diabetes in Chinese adults – China Health and Nutrition Survey, British Journal of Nutrition (2020). DOI: 10.1017/S0007114520003955

https://medicalxpress.com/news/2020-11-easy-eggs-egg-cess-consumpti...

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Baking Soda Boosts T Cells’ Ability to Fight Leukemia

Infusions of donor T cells to fight the cancer often fail, but sodium bicarbonate can counter lactic acid produced by leukemia cells, potentially improving remission rates in mice and humans.

https://www.the-scientist.com/news-opinion/baking-soda-boosts-t-cel...

Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:25am

New technology allows more precise view of the smallest nanoparticles

Current state-of-the-art techniques have clear limitations when it comes to imaging the smallest nanoparticles, making it difficult for researchers to study viruses and other structures at the molecular level.

Scientists from the University of Houston and the University of Texas M.D. Anderson Cancer Center have reported in Nature Communications a new optical imaging technology for nanoscale objects, relying upon unscattered light to detect nanoparticles as small as 25 nanometers in diameter. The technology, known as PANORAMA, uses a glass slide covered with gold nanodiscs, allowing scientists to monitor changes in the transmission of light and determine the target's characteristics.

PANORAMA takes its name from Plasmonic Nano-aperture Label-free Imaging (PlAsmonic NanO-apeRture lAbel-free iMAging), signifying the key characteristics of the technology. PANORAMA can be used to detect, count and determine the size of individual dielectric nanoparticles.

Nareg Ohannesian et al. Plasmonic nano-aperture label-free imaging (PANORAMA), Nature Communications (2020). DOI: 10.1038/s41467-020-19678-w

https://phys.org/news/2020-11-technology-precise-view-smallest-nano...

Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:20am

Fish carcasses deliver toxic mercury pollution to the deepest ocean trenches

The sinking carcasses of fish from near-surface waters deliver toxic mercury pollution to the most remote and inaccessible parts of the world's oceans, including the deepest spot of them all: the 36,000-foot-deep Mariana Trench in the northwest Pacific.

And most of that mercury began its long journey to the deep-sea trenches as atmospheric emissions from coal-fired power plants, mining operations, cement factories, incinerators and other human activities.

Joel D. Blum el al., "Mercury isotopes identify near-surface marine mercury in deep-sea trench biota," PNAS (2020). www.pnas.org/cgi/doi/10.1073/pnas.2012773117

https://phys.org/news/2020-11-fish-carcasses-toxic-mercury-pollutio...

Comment by Dr. Krishna Kumari Challa on November 17, 2020 at 7:14am

Building blocks of life can form long before stars

An international team of scientists have shown that glycine, the simplest amino acid and an important building block of life, can form under the harsh conditions that govern chemistry in space.

The results, published in Nature Astronomy, suggest that glycine, and very likely other amino acids, form in dense interstellar clouds well before they transform into new stars and planets.

Comets are the most pristine material in our Solar System and reflect the molecular composition present at the time our Sun and planets were just about to form. The detection of glycine in the coma of comet 67P/Churyumov-Gerasimenko and in samples returned to Earth from the Stardust mission suggests that amino acids, such as glycine, form long before stars. However until recently, it was thought that glycine formation required energy, setting clear constraints to the environment in which it can be formed.

In the new study the international team of astrophysicists and astrochemical modelers have shown that it is possible for glycine to form on the surface of icy dust grains, in the absence of energy, through 'dark chemistry'. The findings contradict previous studies that have suggested UV radiation was required to produce this molecule.

Dark chemistry refers to chemistry without the need of energetic radiation. In the laboratory researchers were able to simulate the conditions in dark interstellar clouds where cold dust particles are covered by thin layers of ice and subsequently processed by impacting atoms causing precursor species to fragment and reactive intermediates to recombine.

The scientists first showed methylamine, the precursor species of glycine that was detected in the coma of the comet 67P, could form. Then, using a unique ultra-high vacuum setup, equipped with a series of atomic beam lines and accurate diagnostic tools, they were able to confirm glycine could also be formed, and that the presence of water ice was essential in this process.

Further investigation using astrochemical models confirmed the experimental results and allowed the researchers to extrapolate data obtained on a typical laboratory timescale of just one day to interstellar conditions, bridging millions of years.

Once formed, glycine can also become a precursor to other complex organic molecules . Following the same mechanism, in principle, other functional groups can be added to the glycine backbone, resulting in the formation of other amino acids, such as alanine and serine in dark clouds in space. In the end, this enriched organic molecular inventory is included in celestial bodies, like comets, and delivered to young planets, as happened to our Earth and many other planets.

A non-energetic mechanism for glycine formation in the interstellar medium, Nature Astronomy (2020). DOI: 10.1038/s41550-020-01249-0 , www.nature.com/articles/s41550-020-01249-0

https://phys.org/news/2020-11-blocks-life-stars.html?utm_source=nwl...

Comment by Dr. Krishna Kumari Challa on November 16, 2020 at 6:55am

Diagnostic imaging may increase risk of testicular cancer

Early and repeated exposures to diagnostic imaging, such as X-rays and CT scans, may increase the risk of testicular cancer, suggests a new study from Penn Medicine researchers published online in PLOS ONE. “The steady rise in testicular germ cell tumor (TGCT) cases over the past three or four decades suggests there is an environmental exposure risk at play, but no definitive risk factor has ever been identified.

The data suggests that the increased use of diagnostic radiation below the waist in men over that same time may contribute to the increase in incidence.

In this latest research, the authors conducted an observational study of 1,246 men between the ages of 18 and 55 with and without testicular cancer at Penn Medicine. The participants were invited to complete a questionnaire that elicited information on known and presumptive risk factors for testicular cancer and diagnostic imaging during their lifetime, including location on the body and number of exposures, prior to their diagnosis. Tumor samples were also collected.

After adjusting for known risks of testicular cancer, including cryptorchidism and family history, race, age, and other factors, the researchers found that there was a statistically significant increased risk of testicular cancer among those reporting at least three exposures to X-ray, including a colon X-ray, and CT below the waist, compared to men with no such exposure.

Individuals with three or more exposures to diagnostic radiation had a 59 percent increased risk of having TGCT compared to individuals with no exposures to diagnostic radiation. The risk was also elevated for those exposed to diagnostic radiation during the first decade of their life, compared to those first exposed at age 18 years or later.

https://www.pennmedicine.org/news/news-releases/2020/november/diagn....

https://researchnews.cc/news/3586/Diagnostic-imaging-may-increase-r...

Comment by Dr. Krishna Kumari Challa on November 16, 2020 at 6:48am

Compounds block stress-enhanced nicotine intake in rats
Stress is a major cause of relapse after people quit smoking. Worrying situations, such as money or relationship problems, can affect neurotransmitter levels in the brain, leading former smokers to reach for a cigarette. Now, researchers reporting in ACS Pharmacology & Translational Science have discovered that compounds that activate γ-aminobutyric acid (GABA) receptors in the brain can keep rats from self-administering increased levels of nicotine during stressful conditions in an animal model for relapse.

GABA is an inhibitory neurotransmitter that decreases nerve signaling in the brain. When a person experiences stress, their GABA levels can decrease, causing some neurons to become hyperactive. Using an animal model, Burt Sharp and colleagues wanted to find out if giving rats compounds that stimulate GABAA, a specific type of GABA receptor, on certain neurons, called basolateral amygdala principal output neurons, could lessen the rats’ relapse to nicotine during stressful conditions.

In the animal model, rats were taught to press a lever to self-administer nicotine. After a week, the animals were withdrawn from nicotine for 8 days. To cause stress, the researchers confined the rats in a small space. After releasing the rodents, the team injected one of three compounds, called positive allosteric modulators of GABAA, or PAMs, into a specific region of the stressed rats’ brains, and then gave them access to the nicotine-administering levers. Untreated stressed rats pressed the levers about 1.5 times more frequently than they had before the abstinence period, while rats treated with any of the PAMs reduced nicotine intake to levels seen in unstressed rats before the abstinence period. If similar effects are confirmed in humans, novel, selective PAMs could be helpful in alleviating the stress-induced relapse to smoked tobacco, with potentially fewer side effects than GABA administration, the researchers say.
https://www.acs.org/content/acs/en/pressroom/presspacs/2020/acs-pre...
https://researchnews.cc/news/3588/Compounds-block-stress-enhanced-n...

Comment by Dr. Krishna Kumari Challa on November 16, 2020 at 6:36am

How to make a fake supernova

Powerful, mysterious stellar explosions are difficult to understand from afar, so researchers have figured out how to re-create supernovas' extreme physics in the lab and study how outbursts seed the cosmos with elements and energetic particles.

Comment by Dr. Krishna Kumari Challa on November 15, 2020 at 11:50am

Rosetta Comet Mission 

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