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Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 11:00am

World's first blood test for real-time monitoring of cancer treatme...

Cancer patients who are undergoing targeted therapy can look forward to a new blood test that could tell their doctors whether the treatment is working, within one day after the start of the treatment. This will significantly speed up the evaluation process and enable doctors to make adjustments to the treatment plan, if necessary, to improve patients' chances of recovery.

Sijun Pan et al, Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy, Nature Nanotechnology (2021). DOI: 10.1038/s41565-021-00872-w

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How coronavirus aerosols travel through lungs

More than 65% of inhaled coronavirus particles reach the deepest region of our lungs where damage to cells can lead to low blood oxygen levels, new research has discovered, and more of these aerosols reach the right lung than the left.

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Infrared imaging leaves invasive pythons nowhere to hide

For more than 25 years, Burmese pythons have been living and breeding in the Florida Everglades, where they prey on native wildlife and disrupt the region's delicate ecosystems. A new study shows that infrared cameras could make it easier to spot these invasive snakes in the Florida foliage, providing a new tool in the effort to remove them.

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 10:47am

Bacteriophages  prove to be more effective at fighting antibiotic resistance when trained

The threat of antibiotic resistance rises as bacteria continue to evolve to foil even the most powerful modern drug treatments. By 2050, antibiotic resistant-bacteria threaten to claim more than 10 million lives as existing therapies prove ineffective.

Bacteriophage, or "phage," have become a new source of hope against growing antibiotic resistance. Ignored for decades by western science, phages have become the subject of increasing research attention due to their capability to infect and kill bacterial threats.

A new project  has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria. Like a boxer in training ahead of a title bout, pre-trained phages demonstrated they could delay the onset of bacterial resistance.

The trained phage had already experienced ways that the bacteria would try to dodge it. It had 'learned' in a genetic sense. It had already evolved mutations to help it counteract those moves that the bacteria were taking. Scientists are using phage's own improvement algorithm, evolution by natural selection, to regain its therapeutic potential and solve the problem of bacteria evolving resistance to yet another therapy.

The researchers are now extending their findings to research how pre-trained phages perform on bacteria important in clinical settings, such as E. coli. They are also working to evaluate how well training methods work in animal models.

Joshua M. Borin et al, Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance, Proceedings of the National Academy of Sciences (2021). DOI: 10.1073/pnas.2104592118

https://phys.org/news/2021-06-viruses-effective-antibiotic-resistan...

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 10:28am

Turning off lights can save migrating birds from crashing into buildings

Every night during the spring and fall migration seasons, thousands of birds are killed when they crash into illuminated windows, disoriented by the light. But a new study in PNAS shows that darkening just half of a building's windows can make a big difference for birds. Using decades' worth of data and birds collected by Field Museum scientists at Chicago's McCormick Place convention center, the researchers found that on nights when half the windows were darkened, there were 11 times fewer bird collisions during spring migration and 6 times fewer collisions during fall migration than when all the windows were lit.

This  research provides the best evidence yet that migrating birds are attracted to building lights, often causing them to collide with windows and die. And that turning off the lights can save the birds.

Benjamin M. Van Doren el al., "Drivers of fatal bird collisions in an urban center," PNAS (2021). www.pnas.org/cgi/doi/10.1073/pnas.2101666118

https://phys.org/news/2021-06-migrating-birds.html?utm_source=nwlet...

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 10:20am

part 2:

Scientists have known that energized particles that emanate from the sun—such as electrons racing at approximately 45 million miles per hour—precipitate along the Earth's magnetic field lines into the upper atmosphere, where they collide with oxygen and nitrogen molecules, kicking them into an excited state. These excited molecules relax by emitting light, producing the colorful hues of the aurora.

The theory was supported by spacecraft missions that frequently found Alfven waves traveling Earthward above auroras, presumably accelerating electrons along the way. Although space-based measurements had supported the theory, limitations inherent to spacecraft and rocket measurements had prevented a definitive test.

The physicists were able to find confirmatory evidence in a series of experiments conducted at the Large Plasma Device (LPD) in UCLA's Basic Plasma Science Facility, a national collaborative research facility supported jointly by the U.S. Department of Energy and National Science Foundation.

https://phys.org/news/2021-06-physicists-definitive-evidence-aurora...

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 10:20am

Physicists report definitive evidence how auroras are created

The aurora borealis, or northern lights, that fill the sky in high-latitude regions have fascinated people for thousands of years. But how they're created, while theorized, had not been conclusively proven till recently.

In a new study, a team of physicists  reports definitive evidence that the most brilliant auroras are produced by powerful electromagnetic waves during geomagnetic storms. The phenomena, known as Alfven waves, accelerate electrons toward Earth, causing the particles to produce the familiar atmospheric light show.

The study, published online June 7 in the journal Nature Communications, concludes a decades-long quest to demonstrate experimentally the physical mechanisms for the acceleration of electrons by Alfven waves under conditions corresponding to Earth's auroral magnetosphere.

Measurements revealed this small population of electrons undergoes 'resonant acceleration' by the Alfven wave's electric field, similar to a surfer catching a wave and being continually accelerated as the surfer moves along with the wave.

 Laboratory measurements of the physics of auroral electron acceleration by Alfvén waves, Nature Communications (2021). DOI: 10.1038/s41467-021-23377-5 , www.nature.com/articles/s41467-021-23377-5

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 10:13am

A new material made from carbon nanotubes can generate electricity by scavenging energy from its environment

Engineers have discovered a new way of generating electricity using tiny carbon particles that can create a current simply by interacting with liquid surrounding them.

The liquid, an organic solvent, draws electrons out of the particles, generating a current that could be used to drive chemical reactions or to power micro- or nanoscale robots, the researchers say.

"This mechanism is new, and this way of generating energy is completely new.

When a carbon nanotube is coated with layer of fuel, moving pulses of heat, or thermopower waves, travel along the tube, creating an electrical current.

This technology is intriguing because all you have to do is flow a solvent through a bed of these particles. This allows you to do electrochemistry, but with no wires.

In a new study describing this phenomenon, the researchers showed that they could use this electric current to drive a reaction known as alcohol oxidation—an organic chemical reaction that is important in the chemical industry.

Albert Tianxiang Liu et al, Solvent-induced electrochemistry at an electrically asymmetric carbon Janus particle, Nature Communications (2021). DOI: 10.1038/s41467-021-23038-7

https://phys.org/news/2021-06-material-carbon-nanotubes-electricity...

Comment by Dr. Krishna Kumari Challa on June 8, 2021 at 9:56am

A framework to simulate the same physics using two different Hamiltonians

Researchers  have recently been investigating situations in which two distinct Hamiltonians could be used to simulate the same physical phenomena. A Hamiltonian is a function or model used to describe a dynamic system, such as the motion of particles.

In a paper published in Physical Review Letters,  researchers introduced a framework that could prove useful for simulating the same physics with two distinct Hamiltonians. In addition, they provide an example of an analog simulation and show how one could build an alternative version of a digital quantum simulator.

Their result indicates that using the same Hamiltonian is not always a necessary condition. As an example, they showed that the physics of one-axis twisting can be simulated by a spin chain with an external field, even though the one-axis twisting model has infinite range interactions and this spin chain model has only nearest-neighboring interactions. The Hamiltonian of these two models are physically different, i.e. having different energy spectra, but still one can simulate the one with the other if the dynamics starts with special states.

 Simulating the same physics with two distinct Hamiltonians. Physical Review Letters(2021). DOI: 10.1103/PhysRevLett.126.160402.

https://phys.org/news/2021-06-framework-simulate-physics-hamiltonia...

Comment by Dr. Krishna Kumari Challa on June 7, 2021 at 7:02am

Part 4:

Despite that, the Indian recommendation still works out to a wide range across moderate and severe categories — from a low of about 35 mg to a high of 140 mg (for a 70kg person). This is in sharp contrast to the 32mg (total daily dose) recommendation in the US.

Indian government spokespersons have attributed the rise in fungal infections to the fact doctors in the country may have irrationally used steroids.

But given the government’s own guidelines for steroid use are so much higher than in other countries, there should be analysis into whether this may be contributing to the significant rise in fungal infections (3).

Those findings would have profound implications on India’s pandemic management.

Footnotes: 

1. Now we have white and yellow fungi to deal with
2. Potentially fatal 'black fungus' infections in COVID-19 patients
3. Doctors have been blamed for the rise in black fungus in India, but...

Comment by Dr. Krishna Kumari Challa on June 7, 2021 at 6:59am

Part 3: 

A study of ten Indian hospitals found 74% of patients with secondary infections during the first wave were given antibiotics the WHO has said should be used sparingly, and another 9% received antibiotics that were not recommended.

The guidelines should advise the same procedure for moderate and severe cases, that is, to conduct blood cultures before starting patients on antimicrobial therapy to ensure the antibiotics will work, and that they won’t lead to a secondary fungal infection.

One of the recommended COVID treatments of the National Institute of Health in the US is 32mg a day of the steroid methylprednisolone.

In March 2020, Indian guidelines for treatment recommended 1-2mg methyprednisolone per kilo of body weight for patients with severe symptoms (so 70-140mg for a 70kg person).

This was updated in June 2020 with a lower dose of methylprednisolone (35–70mg per day for a 70kg person) for three days for moderate cases and the original recommended dose (70–140mg per day for a 70kg person) for five to seven days for severe cases.

The most recent guideline of April 2021 does not alter the dosage per day but recommended an increased duration of therapy, five to ten days, for both moderate and severe cases.

Comment by Dr. Krishna Kumari Challa on June 7, 2021 at 6:58am

Part 2:

The two most recent versions of COVID treatment guidelines in India (June 27, 2020 and May 24, 2021) rightly state antibiotics should not be prescribed routinely.

Instead, they urge doctors to consider “empiric” antibiotic therapy as per a “local antibiogram” when COVID patients have moderate secondary infections. Empiric antibiotic therapy implies making a diagnosis based on what the literature says is the most likely pathogen (or bug) causing the infection. Antibiograms are sent out to hospitals periodically and they describe the current infections circulating in the area and which antiobiotics work against them.

For severe secondary infections, the guidelines suggest conducting blood cultures to check which antibiotic might work, ideally before the medication is started.

An empirical approach can work effectively only if a majority of COVID facilities treating moderate cases have access to local antibiograms. If they don’t, doctors will usually end up prescribing broad-spectrum antibiotics. Broad-spectrum antiobiotics kill a range of bugs, rather than a specific one, which is risky because they can also kill the good bugs we use to fight off things like fungal infections

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