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Science Simplified!

                       JAI VIGNAN

All about Science - to remove misconceptions and encourage scientific temper

Communicating science to the common people

'To make  them see the world differently through the beautiful lense of  science'

Members: 22
Latest Activity: 5 hours ago

         WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING

     THIS  IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS                                               

“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”             

                    "Being a scientist is a state of mind, not a profession!"

                  "Science, when it's done right, can yield amazing things".

         The Reach of Scientific Research From Labs to Laymen

The aim of science is not only to open a door to infinite knowledge and                                     wisdom but to set a limit to infinite error.

"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.

Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.

If you are scientifically literate the world looks very different to you.

We do science and science communication not because they are easy but because they are difficult!

“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"

 Links to some important articles :

1. Interactive science series...

a. how-to-do-research-and-write-research-papers-part 13

b. Some Qs people asked me on science and my replies to them...

Part 6part-10part-11part-12, part 14  ,  part- 8

part- 1part-2part-4part-5part-16part-17part-18 , part-19 , part-20

part-21 , part-22part-23part-24part-25part-26part-27 , part-28

part-29part-30part-31part-32part-33part-34part-35part-36part-37,

 part-38part-40part-41part-42part-43part-44part-45part-46part-47

Part 48 part49Critical thinking -part 50 , part -51part-52part-53

part-54part-55part-57part-58part-59part-60part-61part-62part-63

part 64, part-65part-66part-67part-68part 69part-70 part-71part-73 ...

.......306

BP variations during pregnancy part-72

who is responsible for the gender of  their children - a man or a woman -part-56

c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7

d. science-s-rules-are-unyielding-they-will-not-be-bent-for-anybody-part-3-

e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9

f. why astrology is pseudo-science part 15

g. How Science is demolishing patriarchal ideas - part-39

2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes

3. Science communication series:

a. science-communication - part 1

b. how-scienitsts-should-communicate-with-laymen - part 2

c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3

d. the-importance-of-science-communication-through-art- part 4

e. why-science-communication-is-geting worse - part  5

f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6

g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7

h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8

i. science-writers-and-communicators-where-are-you - part 9

j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10

k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11

l.  golden-rules-of-science-communication- Part 12

m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13

n. an-informed-patient-is-the-most-cooperative-one -part 14

o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15

p. the-most-difficult-part-of-science-communication - part 16

q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17

r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18

s. is-post-truth-another-name-for-science-communication-failure?

t. why-is-it-difficult-for-scientists-to-have-high-eqs

u. art-and-literature-as-effective-aids-in-science-communication-and teaching

v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them

 ** qs-people-asked-me-on-science-and-my-replies-to-them-part-173

w. why-motivated-perception-influences-your-understanding-of-science

x. science-communication-in-uncertain-times

y. sci-com: why-keep-a-dog-and-bark-yourself

z. How to deal with sci com dilemmas?

 A+. sci-com-what-makes-a-story-news-worthy-in-science

 B+. is-a-perfect-language-important-in-writing-science-stories

C+. sci-com-how-much-entertainment-is-too-much-while-communicating-sc

D+. sci-com-why-can-t-everybody-understand-science-in-the-same-way

E+. how-to-successfully-negotiate-the-science-communication-maze

4. Health related topics:

a. why-antibiotic-resistance-is-increasing-and-how-scientists-are-tr

b. what-might-happen-when-you-take-lots-of-medicines

c. know-your-cesarean-facts-ladies

d. right-facts-about-menstruation

e. answer-to-the-question-why-on-big-c

f. how-scientists-are-identifying-new-preventive-measures-and-cures-

g. what-if-little-creatures-high-jack-your-brain-and-try-to-control-

h. who-knows-better?

i. mycotoxicoses

j. immunotherapy

k. can-rust-from-old-drinking-water-pipes-cause-health-problems

l. pvc-and-cpvc-pipes-should-not-be-used-for-drinking-water-supply

m. melioidosis

n.vaccine-woes

o. desensitization-and-transplant-success-story

p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!

q. swine-flu-the-difficlulties-we-still-face-while-tackling-the-outb

r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine

s. don-t-ignore-these-head-injuries

t. the-detoxification-scam

u. allergic- agony-caused-by-caterpillars-and-moths

General science: 

a.why-do-water-bodies-suddenly-change-colour

b. don-t-knock-down-your-own-life-line

c. the-most-menacing-animal-in-the-world

d. how-exo-planets-are-detected

e. the-importance-of-earth-s-magnetic-field

f. saving-tigers-from-extinction-is-still-a-travail

g. the-importance-of-snakes-in-our-eco-systems

h. understanding-reverse-osmosis

i. the-importance-of-microbiomes

j. crispr-cas9-gene-editing-technique-a-boon-to-fixing-defective-gen

k. biomimicry-a-solution-to-some-of-our-problems

5. the-dilemmas-scientists-face

6. why-we-get-contradictory-reports-in-science

7. be-alert-pseudo-science-and-anti-science-are-on-prowl

8. science-will-answer-your-questions-and-solve-your-problems

9. how-science-debunks-baseless-beliefs

10. climate-science-and-its-relevance

11. the-road-to-a-healthy-life

12. relative-truth-about-gm-crops-and-foods

13. intuition-based-work-is-bad-science

14. how-science-explains-near-death-experiences

15. just-studies-are-different-from-thorough-scientific-research

16. lab-scientists-versus-internet-scientists

17. can-you-challenge-science?

18. the-myth-of-ritual-working

19.science-and-superstitions-how-rational-thinking-can-make-you-work-better

20. comets-are-not-harmful-or-bad-omens-so-enjoy-the-clestial-shows

21. explanation-of-mysterious-lights-during-earthquakes

22. science-can-tell-what-constitutes-the-beauty-of-a-rose

23. what-lessons-can-science-learn-from-tragedies-like-these

24. the-specific-traits-of-a-scientific-mind

25. science-and-the-paranormal

26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?

27. how-the-brain-of-a-polymath-copes-with-all-the-things-it-does

28. how-to-make-scientific-research-in-india-a-success-story

29. getting-rid-of-plastic-the-natural-way

30. why-some-interesting-things-happen-in-nature

31. real-life-stories-that-proves-how-science-helps-you

32. Science and trust series:

a. how-to-trust-science-stories-a-guide-for-common-man

b. trust-in-science-what-makes-people-waver

c. standing-up-for-science-showing-reasons-why-science-should-be-trusted

You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum

( Please go through the comments section below to find scientific research  reports posted on a daily basis and watch videos based on science)

Get interactive...

Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.

Our mail ID: kkartlabin@gmail.com

Discussion Forum

You can see mentally challenged animals if you observe them carefully

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 9 hours ago. 1 Reply

Q: Why don't we see mentally challenged animals?Krishna:Cognitive specialization makes cross-species comparisons more complex, while potentially identifying human cognitive uniqueness that is…Continue

What might happen when you take lots of medicines...

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 15 Replies

What might happen when you take lots of medicines...One of our uncles died of liver cirrhosis ten years back. He never touched alcohol in his life. He didn't have any viral infection to cause this.…Continue

What comes next after death is just recycling of matter and energy, as directed by science. Period!

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa yesterday. 1 Reply

Q: The fact that I was born because I never existed in the first place suggests that, if I never existed after death, I may eventually exist again in the future. But what about the uncertainty of…Continue

Possessing Intelligence and having sensors to detect things around are different things

Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Wednesday. 1 Reply

Q: Humans are thousands times more intelligent and prudent than animals and birds. But why do animals and birds sense natural disasters, earthquakes and storms before they occur? Why don't humans…Continue

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Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 11:19am

To validate their findings further, the researchers used computer simulations to create different virtual tumors, some with surface growth and others with volume growth. The researchers compared the patterns of mutations from the simulations to the patterns found in the real tumor data.

They found that mutation patterns in the real tumors matched the patterns from the volume growth simulations but not the surface growth simulations.

One of the limitations of the study is that it focused on liver cancer, so the findings might not apply universally to all types of cancer. Another limitation is that the study mainly provides insights into the early stages of tumor growth, which might not fully capture the behavior of larger or metastatic types of cancer.

Arman Angaji et al, High-density sampling reveals volume growth in human tumours, eLife (2024). DOI: 10.7554/eLife.95338.2

Part 2

Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 11:18am

Spatial genomics approach shows cancers grow uniformly, challenging the idea of 'two-speed' entities

Researchers have discovered that cancer grows uniformly throughout its mass, rather than at the outer edges. The work, published in the journal eLife, challenges decades-old assumptions about how the disease grows and spreads.

The researchers challenge the old idea  that a tumour is a 'two-speed' entity with rapidly dividing cells on the surface and slower activity in the core. For the last 50 years, researchers have hypothesized that tumors grow faster at their outer edges. Cancer cells on the surface are thought to have natural advantages compared to cells deep within. For example, peripheral cells have better access to nutrients and oxygen from surrounding healthy tissues. They can also get rid of their waste more easily. As a tumor grows, its center gets further and further away from the blood vessels in the area where it is growing. The cells in a tumor's core get less and less oxygen and nutrients. The cells are also under more mechanical pressure, with compression limiting their ability to divide.

Instead, this work shows they are uniformly growing masses, where every region is equally active and has the potential to harbour aggressive mutations.

These  findings have implications for tumor evolution. The constant churn of cells dying and being replaced by new ones throughout the tumour volume gives cancer many opportunities for evolutionary innovations, such as escaping from immune surveillance.

The researchers made the discovery thanks to spatial genomics, a technique used to study the genetic information of cells in their exact locations within a tissue.

The team obtained data from previous studies where hundreds of small samples were taken from different parts of liver tumors, both in two- and three-dimensional space. This provided a detailed map of the mutations throughout the tumor.
They looked at the mutations in each of the samples, and developed a method to measure the direction and spread of these mutations, allowing them to calculate the angles between the positions of parent cells and their mutated offspring.

In the surface growth model, these angles would point outwards. Instead, the researchers found the angles were spread evenly in all directions, showing uniform growth throughout the tumor.

The study also looked at how mutations were spread within the tumor. If cancer cells grew mostly at the edges, mutations would be more clustered. They found that mutations were spread out, suggesting that cells were dividing all over the tumor.
Part 1
Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 11:06am

Tumor cell death can backfire, strengthening cancer's defenses and limiting immunotherapy success

A new study has uncovered an unexpected way cancer cells can escape the immune system, making it harder for treatments to work. The study, published in Cancer Cell, explains how a type of cancer cell death can actually make tumors grow faster by turning off the immune system's ability to fight the cancer.

Researchers  focused on a form of cell death called necroptosis. Previously thought to help the immune system fight cancer, researchers found that when cancer cells die in this way, they can release a molecule called interleukin-1α.

This molecule helps create an environment in the tumor that weakens the immune response, preventing T cells from attacking the cancer.

People thought necroptosis would help the immune system fight cancer, but instead, it seems to make things worse by helping tumors grow. This study shows that interleukin-1α is key to this process, and by blocking it, we might be able to help the immune system do its job.

The study also found that interleukin-1α is released by cancer cells responding to chemotherapy, which could explain why some treatments don't work as well as expected. But there's good news: By blocking interleukin-1α, researchers were able to improve the immune response and make cancer treatments like chemotherapy and immunotherapy more effective in animal models.

By blocking the actions of interleukin-1α, we could make current cancer treatments more successful. Additionally, targeting interleukin-1α can reduce the toxicity associated with chemotherapy, meaning this approach could help patients respond to and better tolerate therapy.

Researchers also discovered that lower levels of interleukin-1α are linked to better outcomes, especially in patients treated with chemotherapy. This suggests that interleukin-1α could be used as a marker to predict how well cancer treatments might work for different patients.

Kay Hänggi et al, Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity, Cancer Cell (2024). DOI: 10.1016/j.ccell.2024.10.014

Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 10:48am

Using a mouse model, this study used global metabolic analysis to investigate changes in metabolites during an enteric infection. The mice were infected with one of two pathogens, L. monocytogenes, which replicates in the intestine, liver and gall bladder, or C. rodentium, which replicates in the caecum and colon.

The different infection groups led to both shared and specific changes in bile metabolites. Moreover, hundreds of new metabolites that are in the bile metabolome were described. More specifically, the researchers found that enteric infection dynamically changes the composition of bile in order to provide intestinal defense.
While these findings bridge a large gap in knowledge regarding bile composition, the researchers note that the 812 bile metabolites identified in this study likely only represent a subset of all bile metabolites.

Ting Zhang et al, Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis, Nature Microbiology (2024). DOI: 10.1038/s41564-024-01862-z

Part 2

Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 10:47am

Intestinal infections can change bile composition, leading to changes in immune function

Intestinal infections can change the composition of liver bile, leading to changes in immune function and gut bacteria, potentially helping fight off harmful bacteria.

Researchers have identified a new axis of host defense by studying what happens during enteric infection—a term that encompasses all types of intestinal infections including so-called "stomach flu."

A new study from infectious disease investigators 

uncovers how bile, a solution produced by the liver and responsible for the absorption of fat, plays a role in the fight against infections.

While the study was conducted in mice, the researchers anticipate that the findings likely apply to humans as well. Results are published in Nature Microbiology.

The changes the researchers  detected in the composition of bile with infection are beneficial for the intestine to clear infection. 

These findings findings reveal the intricate and dynamic nature of bile composition, shedding new light on the liver's critical role in defending the intestine from infection. These insights enhance our understanding of the liver's broader functions in regulating physiological stability and metabolic processes.

Part 1

Comment by Dr. Krishna Kumari Challa on November 27, 2024 at 9:32am

How cancer cells fend off starvation and death from chemotherapy

Laboratory experiments with cancer cells have revealed two ways in which tumors evade drugs designed to starve and kill them.

While chemotherapies successfully treat cancers and extend patients' lives, they are known not to work for everyone for long, as cancer cells rewire the process by which they convert fuel into energy (metabolism) to outmaneuver the drugs' effects. Many of these drugs are so-called antimetabolics, disrupting cell processes needed for tumor growth and survival.

Three such drugs used in the study—raltitrexed, N-(phosphonacetyl)-l-aspartate (PALA), and brequinar—work to prevent cancer cells from making pyrimidines, molecules that are an essential component to genetic letter codes, or nucleotides, that make up RNA and DNA.

Cancer cells must have access to pyrimidine supplies to produce more cancer cells and to produce uridine nucleotides, a primary fuel source for cancer cells as they rapidly reproduce, grow, and die. Disrupting the fast-paced but fragile pyrimidine synthesis pathways, as some chemotherapies are designed to do, can rapidly starve cancer cells and spontaneously lead to them dying (apoptosis).

This new  study shows how cancer cells survive in an environment made hostile by the persistent shortage of the energy from glucose (the chemical term for blood sugar) needed to drive tumor growth.

This better understanding of how cancer cells evade the drugs' attempts to kill them in a low-glucose environment, the researchers say, could lead to the design of better or more effective combination therapies.

Publishing in the journal Nature Metabolism online Nov. 26, study results showed that the low-glucose environment inhabited by cancer cells, or tumor microenvironment, stalls cancer cell consumption of existing uridine nucleotide stores, making the chemotherapies less effective.

Normally, uridine nucleotides would be made and consumed to help make the genetic letter codes and fuel cell metabolism. But when DNA and RNA construction is blocked by these chemotherapies, so too is the consumption of uridine nucleotide pools, the researchers found, as glucose is needed to change one form of uridine, UTP, into another usable form, UDP-glucose.

The irony, researchers say, is that a low-glucose tumor microenvironment is in turn slowing down cellular consumption of uridine nucleotides and presumably slowing down rates of cell death. Researchers say cancer cells need to run out of pyrimidine building blocks, including uridine nucleotides, before the cells will self-destruct.

In other experiments, low-glucose tumor microenvironments were also unable to activate two proteins, BAX and BAK, sitting on the surface of mitochondria, a cell's fuel generator. Activation of these trigger proteins disintegrates the mitochondria, and instantly sets off a series of caspase enzymes that help initiate apoptosis (cell death).

Conclusion of the study:  low glucose slows down the consumption and exhaustion of uridine nucleotides needed to fuel cancer cell growth and hinders resulting apoptosis, or death, in cancer cells.

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition, Nature Metabolism (2024). DOI: 10.1038/s42255-024-01166-w

Comment by Dr. Krishna Kumari Challa on November 26, 2024 at 7:26am

The study identified a quadratic relationship between rainfall and divorce rates, with the highest rates of divorce occurring in years with either extremely low or high rainfall during the breeding season.

An extreme rainfall event in 1997 was a significant outlier in the data, with exceptionally high rainfall correlating with a sharp increase in divorce rates. When this event was excluded from the analysis, a clearer negative relationship between rainfall and divorce emerged.

Despite rainfall impacting divorce rates, the study found no direct link between reproductive success (i.e., the number of offspring produced) and the likelihood of divorce, suggesting that other, as yet unidentified, factors may be influencing partnership stability.

This study adds to the growing body of evidence showing how environmental factors, particularly those linked to climate change, can directly influence the social dynamics and reproductive strategies of wildlife.

As climate change intensifies, it is critical to understand how fluctuations in environmental conditions, such as rainfall, affect the stability of socially monogamous species.

This research not only enhances our understanding of animal behavior in the face of climate variability but also provides valuable insights that could inform conservation efforts for species vulnerable to the effects of climate change.

 A. A. Bentlage et al, Rainfall is associated with divorce in the socially monogamous Seychelles warbler, Journal of Animal Ecology (2024). DOI: 10.1111/1365-2656.14216

Part 2

Comment by Dr. Krishna Kumari Challa on November 26, 2024 at 7:25am

Did you know that birds are separating and divorcing too?

Bird divorce rates may be linked to fluctuations in rainfall

A 16-year study on a closed population of Seychelles warblers (Acrocephalus sechellensis) on Cousin Island, Seychelles, has uncovered significant findings about how environmental factors—specifically rainfall—affect the stability of pair bonds in birds.

An international team of researchers  found that fluctuations in rainfall prior to and during the breeding season significantly influence the likelihood of "divorce" between mates, highlighting the broader implications of climate cahnge for animal reproduction and conservation. The study is published in the Journal of Animal Ecology.

Divorce, in the context of socially monogamous species, refers to the termination of a pair bond while both individuals are still alive. This mating strategy is often associated with poor reproductive success and has been observed in various bird species. However, the relationship between environmental factors, particularly climate fluctuations, and divorce is the new way of studying the problem.

Social monogamy implies that two birds have formed a pair bond and associate with the same partner, usually over many years and even lifetimes. Pair-bonded birds usually live and raise young together.

Researchers analyzed 16 years of data and found a complex, non-linear relationship between  rainfall patterns and divorce rates, with divorce being more likely during years of both low and high rainfall.

This relationship was notably influenced by an extreme climatic event—the 1997 El Niño-induced rainfall spike.

Part 1

Comment by Dr. Krishna Kumari Challa on November 26, 2024 at 7:16am

Scientists create a 'minimal cell membrane' with just two lipids

Lipids, or fats, are essential to life. They form the membranes around cells, protecting them from the outside. In nature, there is an enormous diversity of lipids, with each organism having its own unique combination. But what are the minimum lipid requirements for a cell to survive?

A research team   showed that cells can function with just two lipids. They created a cell with a minimal, adaptable membrane, offering a unique platform to study how lipid complexity evolved and how it can be engineered for synthetic life. Their findings are published in Nature Communications.

Membranes are like bubbles that encapsulate cells and separate them from their surroundings. Membranes also serve as platforms where molecules interact, coordinating processes essential to life.

"There is an enormous diversity of lipids in nature, and almost every organism has its own set of lipids, known as lipidome. Human cells, for example, employ hundreds of different types of lipids. Yet, these different mixtures of lipids, all provide solutions to the same key evolutionary challenges: creating a stable barrier and organizing biomolecules in space and time.

For their study, the group started with mycoplasma mycoides, a naturally simple pathogenic bacterium. Unlike most cells, mycoplasma cannot make its own lipids and must instead use those provided by its host. By systematically supplementing cells with different lipid combinations, the researchers narrowed down the essential combination needed for survival and division.

They found that the cells can survive on a "diet" of just two lipids: cholesterol and another so-called bilayer-forming lipid, phosphatidylcholine.

These two lipids are not necessarily the only ones that could support life but having both a bilayer-forming lipid, which provides the basic structure for the cell membrane, and a non-bilayer-forming lipid, such as cholesterol, which adds stability, seems to be a fundamental requirement.

The team observed the cells with a minimal lipid diet under an electron microscope and saw dramatic effects on cell shape and size. Some cells grew up to ten times their usual size, while others formed unusual shapes and deformations.

The researchers observed that  about half of the cells with only two lipids appeared completely normal. They were round and divided well. Despite the drastic reduction in lipid complexity, they continued to function surprisingly well.

Reverse engineering the complexity of life

Having identified the minimal lipid diet, the researchers applied it to a "minimal cell" called JVCI-Syn3A, which was engineered at the J. Craig Venter Institute to contain only the genes essential for survival. Now, with both a minimal genome and lipidome, this cell provides a powerful new tool for synthetic biology.

This minimal cell system provides a unique platform to study how lipids support life. Using the principles of bottom-up synthetic biology, researchers can now reintroduce different parts of the lipidome in a directed way and explore the corresponding changes in cell function.

This knowledge could one day help us design synthetic cells with bespoke membranes for special applications in biotechnology and medicine.

Isaac Justice et al, A tuneable minimal cell membrane reveals that two lipid species suffice for life, Nature Communications (2024). DOI: 10.1038/s41467-024-53975-y

Comment by Dr. Krishna Kumari Challa on November 26, 2024 at 6:47am

UTIs are extraordinarily common but kidney infections are not—now we know know why

Infections in the lower urinary tract rarely migrate to the kidneys, but the precise mechanism that the human body employs to keep the twin organs disease-free has remained a medical mystery—until now.

A multidisciplinary team solved the conundrum in an elegant series of experiments. Researchers found that highly specialized biological structures called neutrophil extracellular traps—NETs—are pivotal in protecting the kidneys from infection.

NETs are sticky webs of wispy strands that quite literally serve as traps. They ensnare bacteria that attempt to migrate northward to the kidneys from the lower urinary tract. NETs add to an array of antimicrobial activities mounted by the body to beat back infection.

Writing in Science Translational Medicine, the researchers presented compelling evidence that sticky mesh-like immune NETs serve as a crucial antibacterial defense against infection. The team's study not only revealed the presence of NETs in the urinary tract but also answered a longstanding question in UTI research: What spares the kidneys from pathogens?

"These findings highlight the role of NETosis in preventing ascending infections in the urinary tract.

NETosis refers to the formation of NETs, which prevent any of the various species of bacteria—E. coli, Enterococcal faecalis, Proteus mirabilis, among others—from migrating upward from the bladder to the kidneys. The study focused on E. coli, the most common bacterial cause of UTIs.

The process of NETosis is another wonder of human biology. It reveals how the body, and more specifically, the immune system, creates structures to ensnare pathogens. The key entity in NETosis is the neutrophil, an immune cell, which is signaled to undergo a unique form of cell death. As it succumbs, the neutrophil releases its DNA, histones, and granule proteins, leaving behind a mesh-like structure, a net. E. coli and other bacteria become entrapped just as insects are snared by a spider's web. The process of NETosis isn't rare because NETs are found in the urine of healthy people, the researchers confirmed.

Andrew P. Stewart et al, Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test, Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adh5090

 

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