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Comment by Dr. Krishna Kumari Challa on November 25, 2015 at 10:14am

A good diet for you may be bad for me
Eating the same foods can lead to different blood sugar spikes in different people
A sweet can give one person a sugar rush while barely affecting another person, a new study finds, indicating that a food’s glycemic index is in the eater.

People’s blood sugar rises or falls differently even when they eat the exact same fruit, bread, deserts, pizza and many other foods, researchers in Israel report November 19 in Cell. That suggests that diets should be tailored to individuals’ personal characteristics.

The researchers made the discovery after fitting 800 people with blood glucose monitors for a week. The people ate standard breakfasts supplied by the researchers. Although the volunteers all ate the same food, their blood glucose levels after eating those foods varied dramatically. Traits and behaviors such as body mass index, sleep, exercise, blood pressure, cholesterol levels and the kinds of microbes living in people’s intestines are associated with blood glucose responses to food, the researchers conclude.

Those findings indicate that blood sugar spikes after eating depend “not only on what you eat, but how your system processes that food,” says Clay Marsh, an epigenetics researcher at West Virginia University in Morgantown.
Similarly, eating bread produced a post-meal blood sugar level rise of 44 milligrams per deciliter on average in other studies. But some people’s blood sugar rose as little as 15 mg/dl, while others had a spike as high as 79 mg/dl after eating the same amount of bread.
A team led by Elinav and Weizmann computational biologist Eran Segal created a computer algorithm that used 137 personal measurements to predict how much a person’s blood sugar would rise or fall after eating a certain food. When tested on a new group of 100 people, the algorithm correctly predicted the response about 70 percent of the time.

A third group of 26 participants were then given personalized meals. The computer algorithm analyzed each person and then picked diets for 12 of them. A nutritionist chose a “good” and “bad” diet for the remaining participants. Good diets were ones that that minimized blood sugar spikes after eating. Bad diets sent blood sugar skyrocketing. The diets contained the same amount of calories.

It turned out that foods on the “good” diet for one person were sometimes on another participant’s “bad” list, Segal says. For instance, one woman’s blood sugar spiked when she ate tomatoes. But tomatoes were on other people’s healthy list.
The data suggest is that relying on population averages is not only inaccurate, but may even be dangerous in some cases.
For 10 of the 12 people, the computer algorithm correctly predicted responses to the good and bad foods. Nutritionists were equally good at predicting how a person would fare on a given diet, the team found. But the computerized approach could reach more people, the researchers say.

Mixes of microbes living in people’s guts, known as the gut microbiome, also changed with the good and bad diets. Bacteria help break down food and have been implicated in causing obesity and diabetes. This study can’t distinguish whether the microbiome is causing differences in blood sugar responses or being influenced by how a person responds to certain foods, says Peter Turnbaugh, a microbiome researcher at the University of California, San Francisco.

While Turnbaugh agrees that personalized diets would be better than blanket recommendations for improving health, he sees some caveats. “The frustrating thing about all this is that we can learn how to optimize the diet for a given person, but ultimately, you have to stick to that diet.”
http://www.cell.com/cell/abstract/S0092-8674%2815%2901481-6?_return...

Comment by Dr. Krishna Kumari Challa on November 25, 2015 at 9:28am

People here argue that herbal medicines are based on wise knowledge originated in ancient times and spread from generation to generation and therefore cannot have any side effects. This is quite contrary to what has been observed several times by medical practitioners. Here is another proof...

Chinese Herb Suspected To Have Caused Severe Heart Disorder : A 45-year-old Chinese woman experienced severe heart arrhythmia after consuming an extract from the Aconitum plant, also known as devil’s helmet or monkshood.

Chinese physicians have reported a case of potentially lethal cardiovascular symptoms induced by a traditional Chinese medicine component, aconitine, in the Canadian Journal of Cardiology. Based on the case of a woman who presented with aconitine-induced cardiovascular symptoms, the report warns that the use of the natural ingredient may lead to severe poisoning. A 45-year-old Chinese woman was diagnosed with a severe heart-rhythm disorder, bidirectional ventricular tachycardia (BVT), associated with aconitine poisoning. BVT is a rare form of tachycardia (characterized by a resting heart rate over 100 beats per minute) and a distinct pattern of ECG waves on presentation. The patient’s husband reported that she had drunk about 50 milliliters of a medicinal liquid about 30 minutes before she developed a sudden drop in blood pressure and then lost consciousness. The woman had no history of previous heart-rhythm problems and there was no family history of unexpected sudden death or fatal accidents. On examination she had a heart rate of 150 beats per minute and her blood pressure was 50/30. Her skin was cool, moist, and cyanotic. Treatment with the anti-arrhythmic agents amiodarone, metoprolol, lidocaine, and potassium chloride was ineffective. An abdominal ultrasound showed marked gastric retention. A gastric tube was used to suction out the contents of her stomach. After two hours, the patient’s BVT ceased and her circulation improved. Investigation revealed that the patient’s blood was positive for aconitine, a substance produced by the Aconitum plant, also known as devil’s helmet or monkshood. Although well-known for its highly toxic properties, aconitine is the primary ingredient of the traditional Chinese medicine known as Fuzi, a remedy made from the processed lateral roots of Aconitum carmichaeli Debx. It is widely distributed in the southwest provinces of China and is used in small doses for its anti-inflammatory and pain-relieving effects.

http://www.onlinecjc.ca/article/S0828-282X%2815%2900480-8/abstract

Comment by Dr. Krishna Kumari Challa on November 20, 2015 at 7:10am

Horror.. .. of horrors E. coli has developed resistance to last-line of antibiotics, warn scientists.
Bacteria like E. Coli have mutated to be resistant to our last-line of antibiotics and untreateable bugs may already be circulating in several parts of the world, scientists have warned.

Health experts have warned for years that antibiotic resistance could send medicine back to the dark ages, with even the smallest infections proving lethal.

Currently, when all other drugs fail, doctors use polymyxins – such as colistin - as a last resort to treat bacterial infections like E. coli and those which cause pneumonia.
But British scientists have discovered that pigs and meat sold in China are infected with bacteria carrying a new gene which makes them resistant to these rearguard antibiotics.

The MCR-1 gene is in a part of the DNA which can be easily copied and transferred between bacteria leading experts to conclude that ‘pandemic resistance is inevitable.’ The mutated forms were also found in 1322 hospitalised patients in China and is thought to have already spread to Laos and Malaysia.

British scientists and health experts described the discovery as ‘worrying,’ ‘disturbing’ and ‘alarming.’

The emergence of the MCR-1 gene in China heralds a disturbing breach of the last group of antibiotics and an end to our last line of defence against infection, according to Microbiologists.

The effect on human health posed by this new gene cannot be underestimated. The rapid spread of similar antibiotic-resistant genes suggests that all antibiotics will soon be futile in the face of previously treatable gram-negative bacterial infections such as E. coli and salmonella.

“Our investigations in China found that MCR-1 is already prevalent in E. coli samples found in live animals and meat products, and in a small number of human cases.

“MCR-1 is likely to spread to the rest of the world at an alarming rate unless we take a globally coordinated approach to combat it.
The team from Cardiff University and the South China Agricultural University in Guangzhou, China, were first alerted to a possible new deadly strain of  E. coli after a pig at a farm in Shanghai showed resistance to colistin in 2011.

Over the next four years the team took samples from pigs at slaughter across four provinces, and meat sold in markets in Guangzhou. They found a high prevalence of the MCR-1 gene in E coli, with the proportion of positive samples increasing each year.

The researchers also found that the MCR-1 gene has the potential to spread into other epidemic strains such as K. pneumoniae and P. aeruginosa which can cause a variety of diseases from pneumonia to serious blood infections. K pneumonia strains found in hospital patients also carried the mutation.
“The emergence of MCR-1 heralds the breach of the last group of antibiotics. The polymyxins were the last class of antibiotics in which resistance was incapable of spreading from cell to cell.

“Our results reveal the emergence of the first resistance gene that is readily passed between common bacteria, suggesting that the progression from extensive drug resistance to pandemic resistance is inevitable.”

China is one of the world’s largest users and producers of colistin for agriculture and veterinary use. The Chinese Government has already banned vets from using colistin and the researchers are hoping the same prohibition will be applied globally.

Prof Nigel Brown, President of the Microbiology Society, said: “This discovery that resistance to colistin can be transferred between bacteria is alarming.
The new research was published in The Lancet Infectious Diseases.

Comment by Dr. Krishna Kumari Challa on November 20, 2015 at 7:05am

Truffles are not dangerously radioactive now after Chernobyl disaster.

After analyzing 82 specimens of Burgundy truffle (Tuber aestivum) from across Europe, researchers report online November 10 in Biogeosciences Discussions that all of the sought-after delicacies contained insignificant concentrations of radioactive cesium-137.

Some fungi species, including certain mushrooms, sop up radioactive elements from dirt. The 1986 Chernobyl disaster contaminated large swaths of European soils with cesium-137 and prompted concerns that truffles could become radioactive.

The work provides an all clear for Burgundy truffle hunters and connoisseurs around the world, the researchers write. While not radioactive, at more than $400 per kilogram, Burgundy truffles still may not be safe.

Comment by Dr. Krishna Kumari Challa on November 20, 2015 at 7:01am

What makes life impossible on exoplanets?

A team of scientists has suggested that vast amounts of radiation may be making life impossible on some of them like Kepler-438b planet.

As per the University of Warwick research, the atmosphere of the planet, Kepler-438b, is thought to have been stripped away as a result of radiation emitted from a superflaring Red Dwarf star, Kepler-438.

Regularly occurring every few hundred days, the superflares are approximately ten times more powerful than those ever recorded on the Sun and equivalent to the same energy as 100 billion megatons of TNT.

While superflares themselves are unlikely to have a significant impact on Kepler-438b’s atmosphere, a dangerous phenomenon associated with powerful flares, known as a coronal mass ejection (CME), has the potential to strip away any atmosphere and render it uninhabitable.

The planet Kepler-438b, to date the exoplanet with the highest recorded Earth Similarity Index, is both similar in size and temperature to the Earth but is in closer proximity to the Red Dwarf than the Earth is to the Sun.

Lead researcher David Armstrong explained that if the planet, Kepler-438b, has a magnetic field like the Earth, it may be shielded from some of the effects, but if it does not, or the flares are strong enough, it could have lost its atmosphere, be irradiated by extra dangerous radiation and be a much harsher place for life to exist.

The study appears in Monthly Notices of the Royal Astronomical Society.

Comment by Dr. Krishna Kumari Challa on November 18, 2015 at 9:48am

Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have determined how the body responds during times of emergency when it needs more blood cells. In a study published in Nature, researchers report that when tissue damage occurs, in times of excessive bleeding, or during pregnancy, a secondary, emergency blood-formation system is activated in the spleen.

“Hematopoietic, or blood-forming, stem cells reside mainly in the bone marrow, and most newblood cell formation occurs within the bone marrow under normal circumstances. But when there is hematopoietic stress, blood cell formation expands to thespleen,” said Dr. Sean Morrison, CRI Director and Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern Medical Center. “Blood-forming stem cells migrate from the bone marrow to the spleen, which becomes a hematopoietic organ where blood formation then occurs.”

Normally, there are very few blood-forming stem cells in the spleen. But the cells that create the supporting environment for these stem cells are present in the spleen, ready to respond during times of hematopoietic stress and to receive an influx of blood-forming stem cells from the bone marrow.

In characterizing the microenvironment, or niche, which supports blood formation in the spleen, the CRI research team used mouse models to examine the expression patterns of two known niche cell factors, stem cell factor (SCF) and CXCL12. The researchers found that the blood-forming microenvironment in the spleen is found near sinusoidal blood vessels and is created by endothelialcells and perivascular stromal cells – just like the microenvironment in the bone marrow.

“Under emergency conditions, the endothelial cells and perivascular stromal cells that reside in the spleen are induced to proliferate, so they can sustain all the new blood-forming stem cells that migrate into the spleen,” said Dr. Morrison, who is also a CPRIT Scholar in Cancer Research and a Howard Hughes Medical Institute Investigator. “We determined that this process in the spleen is physiologically important for responding to hematopoietic stress; without it, the mice we studied could not maintain normal blood cell counts during pregnancy or quickly regenerate blood cell counts after bleeding or chemotherapy.”

Based on this new information about the spleen’s emergency backup role for blood cell formation, therapeutic interventions could be developed in the future to enhance blood formation following chemotherapy or bone marrow transplantation and thus accelerate the recovery of blood cell counts.

Comment by Dr. Krishna Kumari Challa on November 17, 2015 at 11:41am

Special eye drops raise the hopes for nearsightedness cure
In a five-year clinical trial conducted in Singapore, drops of a drug called atropine seemed to slow the progression of nearsightedness in children. Intriguingly, researchers found that a lower dose of the drug was more effective than higher dosages, in addition to risking fewer side effects. The research was presented Nov. 16, 2015 at the annual meeting of the American Academy of Ophthalmology in Las Vegas and will appear in the February 2016 edition of the journal Ophthalmology.
In high myopia — where the eyeball stretches and becomes too long — isn’t just an inconvenience: It raises the raises the risk of other, more serious eye conditions, such as retinal detachment, macular degeneration, premature cataracts and glaucoma. So the scientists have been trying to find out if there’s any way to reduce the progression of myopia.
tropine drops are approved for use in the United States at a higher concentration than that used in the study. The drops (which are currently used to treat lazy eye in children) can cause light sensitivity and blurry vision up close at higher doses, so researchers set out to determine whether a smaller dose could still be effective without producing side effects. And it did!

Comment by Dr. Krishna Kumari Challa on November 17, 2015 at 6:07am

For the first time scientists correctly predicted the trajectory of space junk
WT1190F, which burned up in Earth's atmosphere Friday, November 13 off the coast of Sri Lanka, as imaged by scientists measuring the re-entry from an airplane. Measuring 3 to 6 feet, the junk was believed to be man-made spacecraft that could have gone off course and turned into space junk orbiting the earth before it entered the atmosphere. In 2013, WT1190F was initially observed by the University of Arizona's Catalina Sky Survey. This event is also an ideal opportunity to test the readiness of space agencies for a possible atmospheric entry and even strong impacts in the future that involve the asteroids and comets which is the highly similar to this WT1190F event. This is the first time that experts have calculated the exact time and location a piece of space junk will collide with Earth. The object's mass was not substantial enough to present a risk to the area, especially given its trajectory into the Indian Ocean. "A piece of a solar panel, for instance, would behave differently than a booster tank", Lowell Observatory planetary astronomer Nick Moskovitz said in a statement before the object's re-entry. The scientists who orchestrated a rapid response to the recently discovered object declared their effort to be a smashing success. NASA scientists were able to forecast the accurate date and time for the re-entry of the space debris. A team from the worldwide Astronomy Center and the UAE Space Agency may be the only people to have seen its final moments in real time. Astronomers had speculated it could be a spent Apollo rocket stage from 1960's or part of a more recent lunar mission. According to EarthSky.org, it was the "first-ever precisely predicted fall of space debris".

Comment by Dr. Krishna Kumari Challa on November 16, 2015 at 8:21am

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Comment by Dr. Krishna Kumari Challa on November 14, 2015 at 9:28am

The human brain facts:
The human brain has 86 billion neurons in all: 69 billion in the cerebellum, a dense lump at the back of the brain that helps orchestrate basic bodily functions and movement; 16 billion in the cerebral cortex, the brain’s thick corona and the seat of our most sophisticated mental talents, such as self-awareness, language, problem solving and abstract thought; and 1 billion in the brain stem and its extensions into the core of the brain.
The human brain is also unique in its unsurpassed gluttony. Although it makes up only 2 percent of body weight, the human brain consumes a whopping 20 percent of the body’s total energy at rest.

Human brain evolution likely required a metabolic trade-off. In order for the brain to grow, other organs, namely the gut, had to shrink, and energy that would typically have gone to the latter was redirected to the former. For evidence, they pointed to data showing that primates with larger brains have smaller intestines. The invention of cooking was crucial to human brain evolution. Soft, cooked foods are much easier to digest than tough raw ones, yielding more calories for less gastrointestinal work. Perhaps, then, learning to cook permitted a bloating of the human brain at the expense of the gut. Other researchers have proposed that similar trade-offs might have occurred between brain and muscle, given how much stronger chimps are than humans.

Again and again, researchers have cited the evolutionary surge in human brain size as the key reason for our exceptionally high degree of intelligence compared to other animals. Yes, a large brain packed with neurons is essential to what we consider high intelligence.

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