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Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 10:21am

Five common controversial tests in Instagram and TikTok posts
Full-body MRI scan: Claimed to test for up to 500 conditions, yet no evidence of benefit for healthy people, while real dangers exist of unnecessary diagnoses and overtreatment.

Multi-cancer early detection tests: Claimed to screen for more than 50 cancers, yet clinical trials are still underway. As yet, there is no evidence that the benefits of screening healthy populations will outweigh the harms of unnecessary cancer diagnoses.

AMH or "egg-timer" test: While beneficial for certain women, this test is falsely promoted to healthy women as a test for fertility, with concerns the results can lead to unnecessary, costly fertility treatments.

Gut microbiome test: Test promises "wellness" via early detection of many conditions—from flatulence to depression—without good evidence of benefit, alongside concerns that test results could lead to medical overuse, causing harm and waste.

Testosterone test: No evidence of benefit for testing healthy men, yet the danger of overuse of treatments; long-term safety of testosterone therapy, in relation to adverse cardiovascular events and early death, has not yet been established.

 Social Media Posts about Medical Tests with Potential for Overdiagnosis, JAMA Network Open (2025). DOI: 10.1001/jamanetworkopen.2024.61940

Part 3

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 10:21am

These findings suggest social media is an open sewer of medical misinformation.

This is a public health crisis that exacerbates overdiagnosis and threatens the sustainability of health systems.

A detailed analysis of the results found that posts from medical doctors, posts mentioning scientific evidence, or scientists themselves and posts from influencers with no financial interest in the tests, tended to be more balanced overall. The research group is currently investigating ways to better regulate this type of misleading medical information on social media.

Given that social media platforms like Instagram are moving away from fact-checking their content, the need for stronger regulation to prevent misleading medical information has gained urgency, say the researchers. 

Part 2

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 10:18am

Study finds influencers promote 'overwhelmingly' misleading information about medical tests on social media

Influencers are promoting "overwhelmingly" misleading information about medical tests on Instagram and TikTok, according to a global University of Sydney-led study published in JAMA Network Open.

Researchers analyzed almost 1,000 posts about five controversial medical screening tests that had been promoted by social media influencers to almost 200 million followers. They found most posts had no reference to scientific evidence, were promotional, had explicit financial interests and failed to mention potential harms.

The tests included full-body MRI scans; genetic testing claiming to identify early signs of 50 cancers; blood tests for testosterone levels; the anti-mullerian hormone (AMH) test which surveys a woman's egg count; and the gut microbiome test. Experts say these tests have limited evidence of benefit in healthy people and could lead to overdiagnosis and overuse.

The vast majority of these posts were overwhelmingly misleading, the study concludes. They are being promoted under the guise of early screening, as a way to take control of your own health. The problem is they are unnecessary for most people and, in some cases, the science backing their efficacy is shaky.

One example is the 'egg timer' or AMH test. It is being heavily marketed to women by influencers as a way of measuring fertility, but experts do not consider it to be reliable. There is the concern that a low result discovered outside the context of a specific medical issue may drive some women to unnecessary, costly fertility interventions.

Another example is the testosterone test, often marketed to men using fear-mongering tactics to then promote testosterone supplements which claim to enhance masculinity and sexual performance. This is risky as the long-term safety of testosterone replacement therapy on cardiovascular health and mortality is still unknown.

One of the underlying themes being used by influencers promoting these tests is that knowledge is power, but most information is cherry-picked. When it comes to health, getting the full picture is so important, and half-truths are often lies.

Among the 982 posts on Instagram and TikTok:

• 87% mentioned the benefits of the tests, yet only 15% mentioned potential harms;
• Only 6% mentioned the risk of overdiagnosis or overtreatment;
• Only 6% mentioned scientific evidence, while 34% used personal anecdotes to promote the test;
• 68% of influencers and other account holders had financial interests in promoting the test (e.g. partnership, collaboration, sponsorship or selling for own profit in some way).

Part 1

The study found 85% of the posts did not mention any test downsides or risks. These tests carry the potential for healthy people to receive unnecessary diagnoses, which could lead to unnecessary medical treatments or impact mental health.

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 9:54am

A protein from tiny tardigrades may help cancer patients tolerate radiation therapy

Radiation can have severe side effects that often end up being too difficult for cancer  patients to tolerate.

Drawing inspiration from a tiny organism that can withstand huge amounts of radiation, researchers  have developed a new strategy that may protect patients from this kind of damage. Their approach makes use of a protein from tardigrades, often also called "water bears," which are usually less than a millimeter in length.

When the researchers injected messenger RNA encoding this protein into mice, they found that it generated enough protein to protect cells' DNA from radiation-induced damage. If developed for use in humans, this approach could benefit many cancer patients, the researchers say.

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades, Nature Biomedical Engineering (2025). DOI: 10.1038/s41551-025-01360-5

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 9:50am

Schizophrenia is reflected in the brain structure, study shows

The symptoms of schizophrenia vary greatly from person to person. A new study appearing in the American Journal of Psychiatry shows how these differences manifest themselves in the structure of the brain.

Schizophrenia is a complex mental health condition that affects perception, thought and emotions. This complexity is reflected in the individual manifestations of the disease: for some patients, perceptual disturbances are the main problem, while for others, cognitive impairments are more prevalent.

In this sense, there is not one schizophrenia, but many, each with different neurobiological profiles, say the specialists.

To do justice to each of these types of schizophrenia, a precision medicine approach would have to be adopted – for example, with therapies that precisely match the respective neurobiological profile.

This requires approaches that look for both individual differences and similarities at the neurobiological level.

In an international multicenter study, a research team examined the variability of brain structure in patients with schizophrenia: Which brain networks show a high degree of individuality and which a high degree of similarity?

The researchers examined several characteristics, including the thickness and surface area of the cerebral cortex, as well as the folding pattern and volume of deeper brain regions.

The data was taken from the ENIGMA collaboration, an international research project that combined imaging data from more than 6,000 people in 22 countries. By comparing the brain structures of several thousand patients with schizophrenia and healthy individuals, the variability of brain structure could be studied with a high degree of reliability.

While variable brain structures in schizophrenia may reflect differences in symptoms between patients, the uniformity of brain folding in the mid-frontal brain area suggests a developmental trait common to people with schizophrenia. Because brain folding is largely completed in early childhood, brain development during this period appears to be less flexible in schizophrenia patients, particularly in areas responsible for linking thinking and feeling processes.

These findings broaden our understanding of the neurobiological basis of schizophrenia.

While uniform brain folding may indicate possible mechanisms of disease development, regions with high variability in brain structure may be relevant for the development of individualized treatment strategies.

Wolfgang Omlor et al, Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study, American Journal of Psychiatry (2025). DOI: 10.1176/appi.ajp.20230806 , psychiatryonline.org/doi/10.1176/appi.ajp.20230806

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 9:37am

Slowing food spoilage without chemicals: Natural tree sap gum and light extend fruit shelf life

Recent studies  have used a natural tree sap gum and light to extend the shelf life of fresh fruit and vegetables to combat food waste.

Researchers used edible coatings made from gum Arabic or acacia gum enriched with extracts from native Australian plants to stop the growth of spoilage causing microorganisms.

The research team also used light and curcumin, a compound extracted from turmeric, to deactivate fungal spores on food.

 Both methods were found to be effective in keeping food fresh for longer.

This was mostly due to the organic acids and phenolic compounds found in the aqueous extracts of plants like Cape York lilly pilly, boonjee tamarind, and Tasmanian pepper leaves.  These extracts showed promising antimicrobial properties and the sensory analysis also revealed the fruit looked and smelled better.

The curcumin-based photosensitization technique completely deactivated the fungal spores responsible for gray mold in fresh produce.

When applied to strawberries, it reduced decay incidence and severity by 20% without compromising the fruit's color or firmness.

 Maral Seididamyeh et al, Gum Arabic edible coating embedded aqueous plant extracts: Interactive effects of partaking components and its effectiveness on cold storage of fresh-cut capsicum, Food Control (2024). DOI: 10.1016/j.foodcont.2023.110267

Maral Seididamyeh et al, Curcumin‐mediated photodynamic treatment to extend the postharvest shelf‐life of strawberries, Journal of Food Science (2024). DOI: 10.1111/1750-3841.17341

Maral Seididamyeh et al, Effect of gum Arabic on antifungal photodynamic activity of curcumin against Botrytis cinerea spores, International Journal of Biological Macromolecules (2024). DOI: 10.1016/j.ijbiomac.2024.137019

Comment by Dr. Krishna Kumari Challa on February 27, 2025 at 9:18am

Hidden risks from plastic-coated fertilizers in soil

Farmers are always looking for smarter ways to boost crop health, and one of the industry's latest game-changers is polymer-coated, controlled-release fertilizers (PC-CRFs). These high-tech soil enhancers deliver nutrients gradually, ensuring plants get exactly what they need when they need it without the waste of traditional methods.

While PC-CRFs can boost crop efficiency, a new study by researchers uncovers a downside—microplastic pollution. As the polymer coatings break down in the soil, they release tiny plastic particles into the environment.

In PC-CRFs, the plant nutrients are enclosed within a microcapsule. This microcapsule is designed to slowly release the fertilizers into the farmland over time. The non-biodegradable coatings left over after this process is complete can be considered microplastics.

This raises concerns about the long-term impact of this microplastic pollution to the health of people and animals.

Since previous studies have detected microplastics in farmland, we are left with big questions like how much is being released, and what kinds of plastics are involved.

 But if PC-CRFs must be used, scientists urge farmers to implement effective storm water management to prevent these microplastics from running off into nearby water sources.

Various soil environments, moisture conditions and soil organisms can impact the disintegration of the microcapsule differently. Also, PC-CRFs may use different types of plastics, so further research is needed to determine the variations between them.

Linkon Bhattacharjee et al, Mechanisms of microplastic generation from polymer-coated controlled-release fertilizers (PC-CRFs), Journal of Hazardous Materials (2025). DOI: 10.1016/j.jhazmat.2024.137082

Comment by Dr. Krishna Kumari Challa on February 26, 2025 at 11:57am

Magnetic microrobots remove blood clots from sheep iliac artery

Researchers  have removed blood clots with wireless magnetic robots. This innovation promises to transform treatment for life-threatening vascular conditions like thrombosis.

Cardiovascular diseases such as thrombosis are a major global health challenge. Each year worldwide, 1 in 4 people die from conditions caused by blood clots. A blood clot blocks a blood vessel, preventing the blood from delivering oxygen to certain areas of the body.

Traditional treatments struggle with clots in hard-to-reach areas. But magnetic microrobots bring hope to patients with otherwise inoperable clots. The screw-shaped robots can navigate through intricate vascular networks since they are operated wirelessly.

In a new study, researchers 

showcase the potential of these microrobots for precise and minimally invasive clot removal. In their experiments, the microrobots removed enough material of a blood clot inside an iliac artery to resume blood flow. The iliac artery, obtained from sheep, was chosen due to its straight and accessible structure.

Their article, titled "Wireless mechanical and hybrid thrombus fragmentation of ex vivo endovascular thrombosis model in the iliac artery," is published in the journal Applied Physics Reviews.

The research highlights three methods for removing blood clots: mechanical fragmentation, chemical dissolution, and a combination of both. The combined approach is the most consistent and safest, as it breaks up clots and dissolves the fragments.

With X-ray guidance, the tiny robot accurately targets clots in complex blood vessels.

The robots are 3D-printed and shaped like tiny screws, each containing a small permanent magnet.

"This tiny magnet, just one millimeter long and one millimeter in diameter, is positioned to rotate the 'screw' in both directions

This allows the robot to swim against the flow and then turn around to swim back. The screw-like design allows them to drill through blood clots effectively.

In addition to breaking up blood clots and restoring blood flow in arteries, the technology has the potential for other targeted treatments. The robots can deliver drugs directly to specific areas in the body where they are needed most.

Marcus C. J. de Boer et al, Wireless mechanical and hybrid thrombus fragmentation of ex vivo endovascular thrombosis model in the iliac artery, Applied Physics Reviews (2025). DOI: 10.1063/5.0233677

Comment by Dr. Krishna Kumari Challa on February 26, 2025 at 11:50am

How and why the same mutations give rise to very different types of leukemia

Myeloid leukemias are among the most aggressive blood cancers and have low survival rates. Today, leukemia patients undergo genetic analysis to identify mutations and select the most appropriate treatment. However, even among patients with the same mutation, disease progression and response to therapy can vary significantly.

A new study has revealed these differences can be explained by the fact that not all blood stem cells respond in the same way when they acquire a mutation, and the previous "state" of the cell influences the development of cancer.

In this regard,  researchers have identified two cell types—one "stronger" and the other more "sensitive" to inflammatory stimuli. This previous feature affects how the disease develops after the acquisition of oncogenic mutations.

By gaining the mutations, both cell states can give rise to leukemia, but with distinct biological properties that respond in a different way to treatment. 

Published in the journal Cell Stem Cell, the findings represent a step forward in understanding the vast diversity of these types of cancers and highlight the importance of analyzing the cellular "state" prior to mutation.

To perform this study, the researchers developed the STRACK technique (Simultaneous Tracking of Recombinase Activation and Clonal Kinetics). STRACK uses genetic bar codes to track each cell and monitor its behavior before and after acquisition of the mutation.

This approach has allowed them for the first time to link the initial state of each cell with later cancerous features.

Furthermore, the use of mouse models has made it possible to study the process in a fully physiological environment, and with controlled genetic features, which reinforces the significance of the findings.

The conclusions drawn by this study suggest that, for leukemia, identifying the genetic mutation alone is not enough to determine the most appropriate treatment. The "previous state" of the cells, which can include their response to repeated inflammation or epigenetic changes, is crucial when predicting the tumor type and its response to treatment.

These findings could apply to other types of cancer as cells in distinct tissues also accumulate "memories" of inflammation or other damage, which would affect their behavior.

Understanding these factors, as well as the mutation, would facilitate the development of even more personalized treatments and preventive strategies focused on the avoidance of habits that predispose to the development of the most aggressive forms of the disease.

Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations, Cell Stem Cell (2025). DOI: 10.1016/j.stem.2025.01.012. www.cell.com/cell-stem-cell/fu … 1934-5909(25)00012-8

Comment by Dr. Krishna Kumari Challa on February 26, 2025 at 11:29am

In the second experiment, the researchers gave the dogs a choice between an empty yellow bowl and food-filled gray bowls. Most of the dogs still went for the yellow bowl, 41 out of 52 times. The team repeated the experiment with even more desirable food, and found the results much the same.

In the third and final experiment, the researchers covered the bowls to prevent the dogs from being able to tell their color and found they then picked randomly, ruling out the possibility of the dogs choosing the yellow bowls in earlier experiments due to scent.
The research team suggests there are potential explanations for the dogs' preference for yellow, such as the ecological valence theory and species-confidence hypothesis, but they acknowledge that these do not fully explain the observed behavior. The authors suggest that further research is needed to understand the ecological advantages or reasons behind this preference.

Anamitra Roy et al, Ready, set, yellow! color preference of Indian free-ranging dogs, Animal Cognition (2025). DOI: 10.1007/s10071-024-01928-9

Part 2

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