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Comment by Dr. Krishna Kumari Challa on December 11, 2014 at 8:38am

Cilia and Diseases
In recent decades, cilia have moved from relative obscurity to a position of importance for understanding multiple complex human diseases. Now termed the ciliopathies, these diseases inflict devastating effects on millions of people worldwide. In this review, written primarily for teachers and students who may not yet be aware of the recent exciting developments in this field, we provide a general overview of our current understanding of cilia and human disease. We start with an introduction to cilia structure and assembly and indicate where they are found in the human body. We then discuss the clinical features of selected ciliopathies, with an emphasis on primary ciliary dyskinesia, polycystic kidney disease, and retinal degeneration. The history of ciliopathy research involves a fascinating interplay between basic and clinical sciences, highlighted in a timeline. Finally, we summarize the relative strengths of individual model organisms for ciliopathy research; many of these are suitable for classroom use.
http://bioscience.oxfordjournals.org/content/64/12/1126
http://www.scientificamerican.com/article/why-scientists-are-blamin...

Comment by Dr. Krishna Kumari Challa on December 11, 2014 at 6:57am

Cancer biology reproducibility effort
eLife has published the first papers from the Reproducibility Project: Cancer Biology.

First announced in October 2013 with $1.3 million in funding from the Laura and John Arnold Foundation, The Reproducibility Project: Cancer Biology (RP:CB) aims to replicate key experimental findings in 50 high-profile cancer biology papers published between 2010 and 2012. The project is a partnership between the Center for Open Science, Science Exchange, and eLife.
Following an earlier effort by the Center for Open Science, in psychology research, the outputs of the cancer biology project are being published in two distinct phases. The first phase involves the production of a Registered Report – a novel publishing format that sets out how the replications will be performed, the reagents and protocols, the sample sizes, and the planned analyses. The replications will be performed by laboratories that are part of the Science Exchange network. The second phase is the publication of these results in a Replication Study. Both the Registered Report and the Replication Study are subject to eLife’s rigorous and consultative peer review process.

An open investigation of the reproducibility of cancer biology rese...

The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.

Find out more details here: http://elifesciences.org/collections/reproducibility-project-cancer...

Comment by Dr. Krishna Kumari Challa on December 10, 2014 at 9:20am

In 1911, Albert Einstein Told Marie Curie To Ignore The Trolls!
A letter addressed from Einstein to famed physicist, chemist, and two-time Nobel-Laureate, Marie Curie tells her to ignore the trolls.
Read it here:
http://einsteinpapers.press.princeton.edu/vol8-trans/34

And his reply to a female fan:

Albert Einstein's Reply to a Female Fan's Confession Should Be in Every Science Textbook

when she said: "I hope you will not think any the less of me for being a girl!"

"I hope you will not think any the less of me for being a girl!"

This plea was sent to Albert Einstein by a young South African in the 1940s, and was recently unearthed as part of Alice Caprice's Dear Professor Einstein: Albert Einstein's Letters to and from Chil.... Although brief, Tyfanny's words capture the self-consciousness and self-doubt that have for so long plagued women who aspire to careers in science and technology.

In the letter, dated Sept. 19, 1946, a seemingly agonized Tyfanny admits to Einstein that she has left out a potentially damaging detail about herself. "I forgot to tell you, in my last letter, that I was a girl. I mean I am a girl," the young scientist writes. "I have always regretted this a great deal, but by now I have become more or less resigned to the fact."

The physicist's pithy response is a timeless lesson that bears repeating, all these decades later. "I do not mind that you are a girl, but the main thing is that you yourself do not mind," the Nobel Prize winner replied. "There is no reason for it."

Comment by Dr. Krishna Kumari Challa on December 10, 2014 at 9:07am

New drug eliminates the malaria parasite within 48 hours in mice

A promising new compound tricks the immune system into destroying red blood cells infected with the malaria parasite in just two days. Trials are now planned in humans.
An international team of scientists has developed an anti-malarial compound that triggers the immune system to destroy red blood cells infected by malaria, but leaves healthy cells unharmed.

The compound, known as (+)-SJ733, has already been tested in mice, and a single dose has been shown to kill 80 percent of malaria parasites in the bloodstream within 24 hours. Within 48 hours the parasite was completely undetectable.
http://www.sciencedaily.com/releases/2014/12/141205175027.htm

Comment by Dr. Krishna Kumari Challa on December 10, 2014 at 8:12am

Magnet Design by Integration of Layer and Chain Magnetic Systems in a π-Stacked Pillared Layer Framework

http://onlinelibrary.wiley.com/doi/10.1002/anie.201410057/abstract;...

Magnets Without Metals A three-dimensional organic framework could help researchers make magnetic materials without metals or metal oxides.

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Comment by Dr. Krishna Kumari Challa on December 8, 2014 at 7:35am

Vaccine myths - busted:

16 Years Ago, A Doctor Published A Study. It Was Completely Made Up, And It Made Us All Sicker.

Once upon a time, a scientist named Dr. Andrew Wakefield published in the medical journal The Lancet that he had discovered a link between autism and vaccines.

After years of controversy and making parents mistrust vaccines, along with collecting $674,000 from lawyers who would benefit from suing vaccine makers, it was discovered he had made the whole thing up. The Lancet publicly apologized and reported that further investigation led to the discovery that he had fabricated everything.

In the intervening years, millions have been spent on studying this further to see if there was anything that could connect autism and vaccines.

Read scientific facts about vaccines here:

http://www.upworthy.com/16-years-ago-a-doctor-published-a-study-it-...

Comment by Dr. Krishna Kumari Challa on December 8, 2014 at 7:11am

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Comment by Dr. Krishna Kumari Challa on December 7, 2014 at 7:29am

Comment by Dr. Krishna Kumari Challa on December 7, 2014 at 6:54am

Comment by Dr. Krishna Kumari Challa on December 7, 2014 at 6:44am

Physicists achieve superconductivity at room temperature

German researchers have figured out how to put a piece of ceramic in a superconducting state at room temperature - no cooling required.
Physicists from the Max Planck Institute for the Structure and Dynamics of Matter have kept a piece of ceramic in a superconducting state, disproving the widely-held assumption that materials need to be cooled to temperatures of at least -140 degrees Celsius to achieve superconductivity.

Superconducting materials have the potential to change everything that relies on electrical power, such as power grids, transportation, and renewable energy sources. This is because they’re able to transport electric currents without any resistance, which means they’re incredibly efficient and cost-effective to run. Except right now, they’re not, because in order to get a material to a superconducting state, it needs to be cooled to near absolute zero temperatures, which has really hampered the potential of this technology up to this point.
Over the past few decades, scientists have come to realise that metals cooled to temperatures of around -273 degrees Celsius using liquid nitrogen or helium aren’t the only materials capable of reaching a superconducting state. During the 1980s, it was discovered that ceramic materials can reach this state at significantly higher (and yet still extremely cold) temperatures of around -200 degrees Celsius. This is why they’re called high-temperature superconductors.
One such ceramic material, called yttrium barium copper oxide (YBCO), has since been singled out, thanks to its great potential for use in a range of technical applications such as superconducting cables, electrical motors, and generators. Made from super-thin double layers of a copper oxide material stacked in-between layers made from barium, copper and oxygen, this material is designed to allow the bonding of electrons into what’s known as Cooper pairs.
These Cooper pairs of electrons are able to ‘tunnel’ between the alternating layers "like ghosts can pass through walls, figuratively speaking - a typical quantum effect,” they report, but it was thought this could only occur at super-cooled temperatures.

But then the physicists from Max Planck decided to see what would happen if they irradiated the YBCO ceramic material with infrared laser pulses. They found that for a fraction of a second, the ceramic becomes superconducting at room temperature. And when we say “a fraction of a second”, they mean a fraction. “It was only a few millionths of a millisecond” . "That's a very, very brief lifespan for our amazing new room temperature superconductor. However, the successful experiment is proof that such a thing is possible."
http://phys.org/news/2014-12-superconductivity-cooling.html

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