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Comment by Dr. Krishna Kumari Challa on May 31, 2015 at 7:30am

How Bacteria Talk and how we can use this knowledge to control diseases

Comment by Dr. Krishna Kumari Challa on May 30, 2015 at 7:30am

Vials of bioterror bacteria have gone missing. Lab mice infected with deadly viruses have escaped, and wild rodents have been found making nests with research waste. Cattle infected in a university's vaccine experiments were repeatedly sent to slaughter and their meat sold for human consumption. Gear meant to protect lab workers from lethal viruses such as Ebola and bird flu has failed, repeatedly.

A USA TODAY Network investigation reveals that hundreds of lab mistakes, safety violations and near-miss incidents have occurred in biological laboratories coast to coast in recent years, putting scientists, their colleagues and sometimes even the public at risk.

Oversight of biological research labs is fragmented, often secretive and largely self-policing, the investigation found. And even when research facilities commit the most egregious safety or security breaches — as more than 100 labs have — federal regulators keep their names secret.

Of particular concern are mishaps occurring at institutions working with the world's most dangerous pathogens in biosafety level 3 and 4 labs — the two highest levels of containment that have proliferated since the 9/11 terror attacks in 2001. Yet there is no publicly available list of these labs, and the scope of their research and safety records are largely unknown to most state health departments charged with responding to disease outbreaks. Even the federal government doesn't know where they all are, the Government Accountability Office has warned for years.
http://www.usatoday.com/longform/news/2015/05/28/biolabs-pathogens-...

Comment by Dr. Krishna Kumari Challa on May 30, 2015 at 7:06am

The link between typhoid bacterium and gallbladder cancer...

Controlling bacterial infections responsible for typhoid fever could dramatically reduce the risk of gallbladder cancer in India and Pakistan, according to a study published by Cell Press May 28th in Cell Host & Microbe. The findings establish for the first time the causal link between bacterial infection and gallbladder cancer, explaining why this type of cancer is rare in the West but common in India and Pakistan, where typhoid fever is endemic. Public policy changes inspired by this research could have an immediate impact on preventing a type of cancer that currently has a very poor prognosis.

S. typhi,   typhoid-causing bacterium is endemic in India and has been associated with gallbladder cancer in epidemiological studies. Moreover, proteins that Salmonella injects into host cells activate cancer-related signaling pathways called AKT and MAPK, which support not only bacterial infection and survival, but also the growth and proliferation of cancer cells.

To explore the role of S. typhi in cancer in the new study, the researchers compared tumor samples from Indian and Dutch patients with gallbladder cancer. While both groups showed signs of AKT and MAPK activation and an inactive, mutant TP53 cancer gene, only Indian patients showed strong evidence of S. typhi infection and over-activating mutations in a cancer gene called c-Myc. To mimic the features of the tumor samples from India, the researchers transplanted Salmonella-infected cells with mutations affecting TP53 and c-Myc activity into mice. These mice later developed tumors, demonstrating that Salmonella causes cancer in genetically at-risk hosts as a result of the collateral damage induced by its normal infection cycle.

Additional experiments suggested that Salmonella infection sets genetically predisposed host cells on the cancerous path by secreting proteins that increase AKT and MAPK activity, which remains elevated and perpetuates the cancer trajectory long after the bacteria have disappeared. These same two host signaling pathways are activated by bacterial pathogens implicated in cervical and lung cancer, suggesting that a direct contribution of bacteria to tumor formation could be more common than previously anticipated. "The findings also suggest that the use of antibiotic treatment to control these bacterial infections may come too late for individuals who have already developed cancer," the researchers say. "Instead, the main goal should be prevention through proper treatment with antibiotics, vaccination programs, or better sanitary conditions."

"If typhoid fever is controlled, gallbladder carcinoma in India and Pakistan could be prevented and become as rare as in the Western world."

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

http://www.sciencedirect.com/science/article/pii/S1931312815002061

Comment by Dr. Krishna Kumari Challa on May 30, 2015 at 6:58am

Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data
http://www.thelancet.com/journals/landia/article/PIIS2213-8587%2815...
Kidney function tests help in measuring over all health
If health care providers have data on kidney damage and kidney function - which they often do - they should be using those data to better understand a patient's risk of cardiovascular disease. Cholesterol levels and blood pressure tests are good indicators of cardiovascular risk, but they are not perfect. This study tells us we could do even better with information that often times we are already collecting.
The most common assessment of kidney function checks the blood for creatinine, a waste product of the muscles, and reflects how well the kidneys are filtering it out (called an estimated glomerular filtration rate, or eGFR). Another key test measures albuminuria, or how much of the protein albumin leaks out of the kidney and into the urine. Higher amounts indicate the presence of kidney damage. It is also a fairly common test, particularly in patients with diabetes, hypertension and kidney disease.
The researchers now  found that both eGFR levels and albuminuria independently improved prediction of cardiovascular disease in general and particularly heart failure and death from heart attack and stroke, but albuminuria was the stronger predictor. It outperformed cholesterol levels and systolic blood pressure - and even whether someone is a smoker - as a risk factor for heart failure and death from heart attack or stroke.
Poorly functioning kidneys can lead to a fluid overload that may result in heart failure. People with kidney disease tend to not receive certain medications that can reduce heart ailments, such as statins, likely because patients with kidney disease frequently are excluded from clinical trials performed to prove the efficacy of these medicines.

People with chronic kidney disease are twice as likely to develop cardiovascular disease as those with healthy kidneys and roughly half of them die from it before they reach kidney failure.

Comment by Dr. Krishna Kumari Challa on May 30, 2015 at 6:43am

A vaccine to lower blood pressure? Scientists have devised one for rats, at least.
Scientists jabbed hypertensive rats with three doses of the formulation. It's a DNA vaccine—containing DNA fragments from angiotensin II—a hormone that boosts blood pressure, as well as fragments from hepatitis B, to guarantee the immune system’s attention. Cells suck up the vaccine's DNA, and start pumping out the proteins the DNA codes for. When the host’s defenses gets a whiff of the proteins, it reacts. It really revs up against the hepatitis B fragments. And while it’s at it, it starts taking out some angiotensin II as well.

The result is a reduction in angiotensin II's usual blood pressure raising effects—similar to what blood pressure meds like Benicar do. Less angiotensin II means more relaxed blood vessels, and a drop in pressure. That effect lasted six months in the vaccinated rats, and lengthened their lifespan by eight weeks. Necropsies on the vaccinated rats revealed healthier heart tissue than normally found with high blood pressure, and no damage to their kidneys or livers. The results are in the journal Hypertension
"Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats"
http://hyper.ahajournals.org/content/early/2015/05/26/HYPERTENSIONA...

Comment by Dr. Krishna Kumari Challa on May 28, 2015 at 8:10am

Why ovarian cancer treatments fail ...

Ovarian cancer cells can lock into survival mode and avoid being destroyed by chemotherapy, an international study reports.

Professor Sean Grimmond, from The University of Queensland's Institute for Molecular Bioscience, said ovarian cancer cells had at least four different ways to avoid being destroyed by platinum-based chemotherapy treatments.

"One way involves breaking and rearranging big groups of genes - the chromosomes," Professor Grimmond said.

"This is fundamentally different to other cancers where the disease is driven by smaller but more gradual changes to individual genes.

"It is essentially shattering big chunks of the cell's hard drive and moving them around, rather than just changing bits in the files."

The research used whole genome sequencing to analyse tumour DNA samples from 91 patients with high-grade serous ovarian cancer (HGSC).

The study's results are published recently in Nature.

Comment by Dr. Krishna Kumari Challa on May 26, 2015 at 9:50am

Comment by Dr. Krishna Kumari Challa on May 23, 2015 at 9:29am

‘Plastic Rice’. 'Synthetic rice'. Have you heard these terms before? One more rice contaminant!
Several Indonesian regions are on alert after lab tests confirmed rice found in the West Java city of Bekasi, on the outskirts of Jakarta, contained plastic compounds.

Lab results from state-controlled inspection firm Superintending Company of Indonesia, or Sucofindo, revealed that two rice samples collected from Mutiara Gading market in Bekasi contained contained benzyl butyl phthalate, 2-ethylhexyl phthalate and diisononyl phthalate, also known as plasticizer.

“The two samples of rice look the same; results of our tests show that both contain plastic compounds,” Adisam Z.N., Sucofindo’s laboratory examinations head, said in Jakarta on Thursday.

“Plasticizers are usually used in the production of cables and plastic pipes. In Europe, these substances have been banned for use in children’s toys, let alone as food substances,” he added.

Long-term consumption of the synthetic rice, dubbed “plastic rice” by local media, can cause abdominal pain and even cancer.

Fears of the so-called synthetic rice have spread across the country after a police raid at Mutiara Gading found evidence of it mixed with real grains of rice.
Synthetic rice had slightly different physical attributes compared to natural grains, such as sharper tips.

Rice traders in Jakarta have admitted to not knowing the difference before they were informed by authorities.
http://thejakartaglobe.beritasatu.com/news/authorities-alert-plasti...

Comment by Dr. Krishna Kumari Challa on May 23, 2015 at 9:03am

“Young Blood” Anti-Aging Mechanism Called into Question

A protein in the blood of young mice that seemed to rejuvenate older animals may do the opposite
http://www.nature.com/news/young-blood-anti-ageing-mechanism-called...

Comment by Dr. Krishna Kumari Challa on May 19, 2015 at 8:56am

Scientists want contracts to guarantee they won't be muzzled
Canada’s muzzled federal scientists claim they are now being barred from meeting with their union at work to discuss its bargaining proposals to restore “scientific integrity” in government, says the union.

Debi Daviau, president of the Professional Institute of the Public Service of Canada, is leading scientists Tuesday in a string of outdoor protests at labs and science-based departments across the country largely because the union can no longer get inside to meet with their members as it once did.
Federal scientists were a thorn in the Conservatives’ side during the government’s downsizing, accusing them of using federal policies to muzzle them, change or suppress their findings and undermine their ability to do their jobs.
The policy would touch on a range of issues and existing policies, but the key proposal is the “right to speak.” The union wants a clause guaranteeing scientists the right to express their personal views while making clear they don’t speak for government.

The other big demand is professional development, allowing scientists to attend meetings, conferences and courses to maintain their professional standards.

They also want contract changes so half of the revenues generated by their inventions and other intellectual property will be plowed back into government research to shore up budgets hit by spending cuts and to attract top talent.

PIPSC argues the changes would ensure science is done in the public interest, information and data are shared, and that scientists can collaborate and be protected from political interference, coercion or pressure to alter data. The policy would touch on a range of issues and existing policies, but the key proposal is the “right to speak.”
http://ottawacitizen.com/news/national/scientists-want-contracts-to...

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