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Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 10:56am

How brain processes contribute to different types of delusions

Delusions—fixed false beliefs—can be tricky to study. And it's not yet clear how the brain gives rise to these departures from reality. Further, there are many types of delusions. Those with persecutory delusions or paranoia, for example, believe others have harmful intentions toward them, while individuals with delusions of control believe others have command over their thoughts.

In a study published in the journal Brain,  researchers began to tease apart how brain processes contribute to different types of delusions.

For the study, volunteers with either paranoid or non-paranoid delusion-like beliefs performed two computer tasks. In one, the rules for winning changed over time, requiring participants to update their beliefs. The second task evaluated to what extent established information blocked participants' learning of new information.

Essentially, the tasks were aimed at observing how people formed beliefs and how they changed them. 

The researchers found that people with delusion-like beliefs performed differently than healthy individuals. But they also found that people with paranoid and non-paranoid beliefs performed differently than each other, which hasn't been observed before.

The findings suggest that learning dynamics have a significant role in how different types of delusions arise, which could inform how to predict risk of psychosis across individuals. 

Rosa Rossi-Goldthorpe et al, Different learning aberrations relate to delusion-like beliefs with different contents, Brain (2024). DOI: 10.1093/brain/awae122

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Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 9:45am

Protein in mosquito saliva shown to inhibit host immune response

Mosquito saliva is known to play a significant role in the transmission of viruses such as yellow fever, Zika, dengue, and chikungunya, yet many of its functions have yet to be understood. In a new study, researchers revealed that a mosquito salivary protein binds to an immune molecule in humans, facilitating infection in human skin caused by the transmitted virus.

The findings are published in Science Immunology.

Ticks and mosquitoes don't just inject pathogens. Their saliva serves many purposes when it interacts with the human host. 

For the study, the team probed a curated yeast display library of human proteins with Nest1, a  protein in the Aedes aegypti mosquito saliva that they had identified as important in previous research.

The researchers demonstrated that Nest1 interacts with human CD47, an immune receptor found on the surface of many cells in the body. CD47 controls several immune processes, including those that protect certain cells and destroy others.

This interaction shows that the mosquito is trying to change the biological functions governed by CD47.  Nest1 is inhibiting some of these functions, like phagocytosis, the migration of immune cells, and the inflammatory response." These alterations help to enhance virus replication in the skin.

This discovery increases our knowledge of how disease vectors—like mosquitoes—and hosts—like humans—interact.

Alejandro Marin-Lopez et al, The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity, Science Immunology (2024). DOI: 10.1126/sciimmunol.adk9872

Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 9:35am

Scientists achieve more than 98% efficiency in removing nanoplastics from water

 Scientists are battling against an emerging enemy of human health: nanoplastics. Much smaller in size than the diameter of an average human hair, nanoplastics are invisible to the naked eye.

Linked to cardiovascular and respiratory diseases in people, nanoplastics continue to build up, largely unnoticed, in the world's bodies of water. The challenge remains to develop a cost-effective solution to get rid of nanoplastics while leaving clean water behind.

 Recently, researchers created a new liquid-based solution that eliminates more than 98% of these microscopic plastic particles from water.

The innovative method—using water-repelling solvents made from natural ingredients—not only offers a practical solution to the pressing issue of nanoplastic pollution but also paves the way for further research and development in advanced water purification technologies.

The strategy uses a small amount of designer solvent to absorb plastic particles from a large volume of water.

Initially, the solvent sits on the water's surface the way oil floats on water. Once mixed with water and allowed to separate again, the solvent floats back to the surface, carrying the nanoplastics within its molecular structure.

In the lab, the researchers simply use a pipette to remove the nanoplastic-laden solvent, leaving behind clean, plastic-free water. The researchers  say future studies will work to scale up the entire process so that it can be applied to larger bodies of water like lakes and, eventually, oceans.

The solvents used are made from safe, non-toxic components, and their ability to repel water prevents additional contamination of water sources, making them a highly sustainable solution.

Piyuni Ishtaweera et al, Nanoplastics Extraction from Water by Hydrophobic Deep Eutectic Solvents, ACS Applied Engineering Materials (2024). DOI: 10.1021/acsaenm.4c00159

Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 9:09am

Scientists never like uncertainty. In fact, much of their research tries to place bounds on certain parameters, like the rotational speed of galaxies or the distances between them. Unfortunately, despite their proximity, there are many uncertainties surrounding the four galaxies used in the study, and those uncertainties make precise calculations of the effects of their gravitational and rotational pull difficult.

Developing estimates rather than concrete numbers is one way scientists often deal with uncertainty, and in this case, that estimate fell right at the 50% mark in terms of whether or not the two galaxies would collide. However, there is still a lot of uncertainty in that estimate, and plenty more confounding factors, including the other galaxies in the local group, will influence the final outcome.

Ultimately, time will help solve the mystery, but that is a very long time on the scale of galaxy mergers. If it happens at all, a merger between the Milky Way and Andromeda will happen long after our own sun has burned out, and humans will either die out with it or find a way to expand to new stars. And if, at that point, we get easy access to an additional galaxy's worth of resources, it would be all the better for us.

Till Sawala et al, Apocalypse When? No Certainty of a Milky Way -- Andromeda Collision, arXiv (2024). DOI: 10.48550/arxiv.2408.00064

Part 2

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Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 9:07am

Are Andromeda and the Milky Way doomed to collide? Maybe not

Scientists discovered the Andromeda galaxy, known as M31, hundreds of years ago, and around a century ago, we realized that it had negative radial velocity toward the Milky Way. In other words, eventually, the two galaxies would merge spectacularly. That has been common knowledge for astronomers since then, but is it really true?

A new paper from researchers at the University of Helsinki posted to the arXiv preprint server looks at several confounding factors, including the gravitational influence of other galaxies in our local group, and finds only a 50% chance that the Milky Way will merge with the Andromeda galaxy in the next 10 billion years.

That seems like a pretty big thing to get the physics wrong on. So, how did the authors come to that conclusion? They accounted for a problem that has been popularized in media as of late—the three-body—or in this case, four-body—problem. And with that problem comes a lot of uncertainty, which is why there's still a 50% chance that this huge event might still happen.

Thinking of Andromeda and the Milky Way in isolation doesn't account for the other galaxies in what we know as the "Local Group." This comprises approximately 100 smaller galaxies at various orientations, distances, and speeds.

The largest of the remaining galaxies is the Triangulum galaxy, M33, which is about 2.7 million light-years away and consists of upwards of a mere 40 billion stars. That's about 40% of the approximately 100 billion stars in the Milky Way but a mere 4% of the nearly 1 trillion stars estimated to exist in Andromeda. Still, they would have their own gravitational pull, contorting the simplistic dynamic between Andromeda and the Milky Way.

Part 1

Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 8:26am

Algorithm achieves 98% accuracy in disease prediction via tongue colour

A computer algorithm has achieved 98% accuracy in predicting different diseases by analyzing the colour of the human tongue.

The proposed imaging system developed by Iraqi and Australian researchers can diagnose diabetes, stroke, anemia, asthma, liver and gallbladder conditions, COVID-19, and a range of vascular and gastrointestinal issues.

The artificial intelligence (AI) model was able to match the tongue color with the disease in almost all cases.

A paper published in Technologies outlines how the proposed system analyzes tongue color to provide on-the-spot diagnosis, confirming that AI holds the key to many advances in medicine.

The color, shape and thickness of the tongue can reveal a litany of health conditions.

Typically, people with diabetes have a yellow tongue; cancer patients a purple tongue with a thick greasy coating; and acute stroke patients present with an unusually shaped red tongue. A white tongue can indicate anemia; people with severe cases of COVID-19 are likely to have a deep red tongue; and an indigo or violet colored tongue indicates vascular and gastrointestinal issues or asthma.

In the study, cameras placed 20 centimeters from a patient captured their tongue color and the imaging system predicted their health condition in real time.

 Ali Raad Hassoon et al, Tongue Disease Prediction Based on Machine Learning Algorithms, Technologies (2024). DOI: 10.3390/technologies12070097

Comment by Dr. Krishna Kumari Challa on August 14, 2024 at 8:17am

Significant link found between heme iron, found in red meat and other animal products, and type 2 diabetes risk

Higher intake of heme iron, the type found in red meat and other animal products—as opposed to non-heme iron, found mostly in plant-based foods—was associated with a higher risk of developing type 2 diabetes (T2D) in a new study  by researchers. While the link between heme iron and T2D has been reported previously, the study's findings more clearly establish and explain the link.

The researchers assessed the link between iron and T2D using 36 years of dietary reports from 206,615 adults enrolled in the Nurses' Health Studies I and II and the Health Professionals Follow-up Study. They examined participants' intake of various forms of iron—total, heme, non-heme, dietary (from foods), and supplemental (from supplements)—and their T2D status, controlling for other health and lifestyle factors.

The researchers also analyzed the biological mechanisms underpinning heme iron's relationship to T2D among smaller subsets of the participants. They looked at 37,544 participants' plasma metabolic biomarkers, including those related to insulin levels, blood sugar, blood lipids, inflammation, and two biomarkers of iron metabolism. They then looked at 9,024 participants' metabolomic profiles—plasma levels of small-molecule metabolites, which are substances derived from bodily processes such as breaking down food or chemicals.

The study found a significant association between higher heme iron intake and T2D risk. Participants in the highest intake group had a 26% higher risk of developing T2D than those in the lowest intake group. In addition, the researchers found that heme iron accounted for more than half of the T2D risk associated with unprocessed red meat and a moderate proportion of the risk for several T2D-related dietary patterns. In line with previous studies, the researchers found no significant associations between intakes of non-heme iron from diet or supplements and risk of T2D.

The study also found that higher heme iron intake was associated with blood metabolic biomarkers associated with T2D. A higher heme iron intake was associated with higher levels of biomarkers such as C-peptide, triglycerides, C-reactive protein, leptin, and markers of iron overload, as well as lower levels of beneficial biomarkers like HDL cholesterol and adiponectin.

The researchers also identified a dozen blood metabolites—including L-valine, L-lysine, uric acid, and several lipid metabolites—that may play a role in the link between heme iron intake and TD2 risk. These metabolites have been previously associated with risk of T2D.

But  the findings—based on a study population that was mostly white—must be replicated in other racial and ethnic groups to get established.

Integration of epidemiological and blood biomarker analysis links heme iron intake to increased type 2 diabetes risk, Nature Metabolism (2024). DOI: 10.1038/s42255-024-01109-5

On a population level, the study findings carry important implications for dietary guidelines and public health strategies to reduce rates of diabetes, according to the researchers. In particular, the findings raise concerns about the addition of heme to plant-based meat alternatives to enhance their meaty flavor and appearance. These products are gaining in popularity, but health effects warrant further investigation.

Comment by Dr. Krishna Kumari Challa on August 13, 2024 at 11:14am

Excessive heat can affect your mental health

While extreme heat can cause physical harm, it can also wreak havoc with your mental health.

Sizzling temperatures can make anyone irritable, but it can be far worse for some, especially those with mental health conditions. Excessive heat can trigger feelings of anger, irritability, aggression, discomfort, stress and fatigue because of its impact on serotonin, the neurotransmitter that regulates your sleep, mood and behaviours.

The most vulnerable groups include people with preexisting mental health conditions and people who abuse alcohol or other drugs.

All mental illnesses increase with heat because it results in more fatigue, irritability and anxiety, and it can exacerbate depressive episodes.

What are the signs of impending trouble? They tend to start with irritability, decreased motivation, aggressive behavior and sometimes mental fogging. In worse cases, confusion and disorientation occur.

If you take medications, consult with your provider because some medications for mental health, such as lithium for bipolar patients, don't pair well with heat. Lithium goes through the kidney, so sweating can have an impact on the levels of the medication in your body.

Droughts and extreme changes in temperature can also increase levels of pollutants and allergens as air quality worsens. That can exacerbate mental health issues like depression, anxiety or PTSD. Some studies show that exposure to any natural climate disaster can raise the risk of depression by more than 30%, anxiety by 70% and both by over 87%.

If you feel affected by severe heat, call your doctor or mental health specialist.

https://www.apa.org/monitor/2024/06/heat-affects-mental-health

Comment by Dr. Krishna Kumari Challa on August 13, 2024 at 11:08am

Brain biomarker in blood sample predicts stroke, researchers demonstrate

Researchers  have demonstrated that a simple blood test that reflects brain health can predict which people are most at risk of suffering a stroke. The discovery could contribute to more individualized treatment of patients with atrial fibrillation. The study has been published in the journal Circulation.

Atrial fibrillation is the most frequent cardiac arrhythmia, affecting around a third of all people at some point in their life. Atrial fibrillation is a common cause of stroke, since the cardiac arrhythmia increases the risk of blood clots forming in the heart's atria. Many people with atrial fibrillation therefore receive anticoagulation treatment with a view to preventing stroke.

However, since anticoagulation treatment leads to an increased risk of serious hemorrhages, only people with a moderate or high risk of experiencing a stroke receive this treatment, instead of all people with atrial fibrillation. This makes it important to be able to identify, with as high a degree of precision as possible, the individuals who will benefit from anticoagulation treatment.

The researchers have now analyzed the substance neurofilament, a protein that is released from the brain in cases of injurious strain and hypoxia, in blood samples from more than 3,000 people with atrial fibrillation. The researchers then followed these people for an average of one and a half years. The individuals with the highest neurofilament levels in their blood had the highest risk of suffering a stroke. The risk of stroke among the quarter with the highest neurofilament levels was more than three times as high as for those with the lowest levels.

As the risk of suffering a stroke determines which type of treatment is appropriate, this can help to increase the precision in the selection of treatment.

When the researchers then combined neurofilament with ordinary cardiac blood samples from the same individuals, this further increased the ability to predict stroke.

Julia Aulin et al, Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation, Circulation (2024). DOI: 10.1161/CIRCULATIONAHA.124.069440

Comment by Dr. Krishna Kumari Challa on August 13, 2024 at 10:39am

Pre-surgical antibody treatment might prevent heart transplant rejection

A new study from scientists  suggests there may be a way to further protect transplanted hearts from rejection by preparing the donor organ and the recipient with an anti-inflammatory antibody treatment before surgery occurs.

The findings, published online in the Proceedings of the National Academy of Sciences , focus on blocking an innate immune response that normally occurs in response to microbial infections. The same response has been shown to drive dangerous inflammation in transplanted hearts.

In the new study—in mice—transplanted hearts functioned for longer periods when the organ recipients also received the novel antibody treatment. Now the first of a complex series of steps has begun to determine whether a similar approach can be safely performed for human heart transplants.

The anti-rejection regimens currently in use are broad immunosuppressive agents that make the patients susceptible to infections. By using specific antibodies, scientists think they can just block the inflammation that leads to rejection but leave anti-microbial immunity intact.

 Pasare, Chandrashekhar, Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2401658121

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