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Comment by Dr. Krishna Kumari Challa on September 3, 2014 at 6:53am

Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3622.html
A quick method detects by-products of the parasite's growth in the blood and is more portable and less error-prone than conventional tests
Jongyoon Han, a bioengineer at the Singapore-MIT Alliance for Research and Technology Centre, and his colleagues, have devised a diagnostic test that avoids many of the problems faced by today's anlysts. Their method, described in a paper published on 31 August in Nature Medicine, works with a tiny droplet — as little as 10 microlitres — of blood, and can provide a diagnosis in just a few minutes. In addition, it does not rely on the expertise of a technician.

When P. falciparum invades red blood cells and feeds on their contents, it breaks down haemoglobin into amino acids and haem, a chemical compound that contains iron. Free haem is toxic, so the parasite quickly converts it into an insoluble crystal known as haemozoin.

“Haemozoin crystals behave like little magnets,” explains Han. He and his team used a technique called magnetic resonance relaxometry (MRR) to detect the magnetic signal of haemozoin in human blood samples that they infected with P. falciparum, and in samples from mice infected withPlasmodium berghei, a mouse model of the disease.

MRR is a type of nuclear magnetic resonance (NMR) spectroscopy, a workhorse of chemical analysis. Although NMR machines are notoriously bulky, in recent years researchers have scaled them down to sizes small enough to fit on a benchtop. Another important step towards bringing the technique to the field, Han says, was that his team was able to detect haemozoin directly in the blood sample without first processing it in the lab.

Comment by Dr. Krishna Kumari Challa on August 30, 2014 at 8:17am

First Global Conference on Science Advice to Governments
Responding to the increasingly global nature of societal challenges, practitioners of science advice to governments formed a global network to share practice and strengthen their ties, at the first global conference on science advice to governments, which was held in Auckland, New Zealand on 28-29 August, 2014.
This Science Advice to Governments meeting had its origin in an editorial in Nature two years ago by James Wilsdon and Robert Doubleday
Summary of Panel 3: Science advice in the context of opposing political/ideological positions
Posted on August 28, 2014

One of the most difficult situations for science advisors to government is when evidence contradicts entrenched political (ideological) positions, whether these are within national, regional or local governments. Well established examples are seen in debates around controlled substances and public health.

Panellists discussed what models of science advice giving (ex: individual experts; commissioned reports; representative committees) have worked best in participating countries.
For more details please visit:
http://www.globalscienceadvice.org/

Comment by Dr. Krishna Kumari Challa on August 27, 2014 at 7:27am

Forces driving epithelial wound healing
Abstract of the research paper:
A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and ‘purse-string’ contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate.
http://www.nature.com/nphys/journal/vaop/ncurrent/full/nphys3040.html

Comment by Dr. Krishna Kumari Challa on August 26, 2014 at 6:05am

Comment by Dr. Krishna Kumari Challa on August 21, 2014 at 11:31am

Mapping the Mind: An Interview with Eric Kandel from Imaginal Disc on Vimeo.

Comment by Dr. Krishna Kumari Challa on August 21, 2014 at 11:21am

At higher levels, fluoride in drinking water can lead to pitted teeth and discoloration. It also makes bones brittle and more prone to fractures. And recent studies have also linked high levels of fluoride exposure with IQ deficits.

Comment by Dr. Krishna Kumari Challa on August 20, 2014 at 11:35am

http://www.researchgate.net/publication/264545425_Low-Intensity_Rep...

Comment by Dr. Krishna Kumari Challa on August 20, 2014 at 11:31am

A new study shows that weak electromagnetic stimulation could reorganize the brain with few side effects.
Researchers have shown that electromagnetic stimulation can alter brain organization which may make your brain work better.

In results from a study published in the Journal of Neuroscience, researchers from The University of Western Australia and the Université Pierre et Marie Curie in France demonstrated that weak sequential electromagnetic pulses (repetitive transcranial magnetic stimulation, or rTMS) on mice can shift abnormal neural connections to more normal locations.

The discovery has important implications for treatment of many nervous system disorders related to abnormal brain organisation such as depression, epilepsy and tinnitus.

Comment by Dr. Krishna Kumari Challa on August 20, 2014 at 11:28am

How You Meditate Matters
Research shows that Vajrayana meditation can enhance cognitive performance, while Theravada meditation is relaxing.
not all meditation techniques produce similar effects of body and mind. Indeed, a study published in PLoS One demonstrates that different types of Buddhist meditation—namely the Vajrayana and Theravada styles of meditation—elicit qualitatively different influences on human physiology and behaviour, producing arousal and relaxation responses respectively.
The researchers had also observed an immediate dramatic increase in performance on cognitive tasks following only Vajrayana styles of meditation. They noted that such dramatic boost in attentional capacity is impossible during a state of relaxation. Their results show that Vajrayana and Theravada styles of meditation are based on different neurophysiological mechanisms, which give rise to either an arousal or relaxation response.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone....

Comment by Dr. Krishna Kumari Challa on August 20, 2014 at 11:22am

Bypassing The Brain To Walk Again
Bypassing the spinal cord with an artificial neural connection enables subjects to control their legs by swinging their arms.
A Japanese research group has successfully made an artificial connection from the brain to the locomotion center, bypassing the spinal cord with a computer interface. This research, published in the Journal of Neuroscience, allowed subjects to perform a walking-like behavior in their legs by swinging their arms.
Neural networks in the locomotion center of the spinal cord are capable of producing rhythmic movements, such as swimming and walking, even when isolated from the brain. The brain controls the spinal locomotion center by sending commands to the spinal locomotion center to start, stop and change waking speed. In most cases of spinal cord injury, the loss of this link from the brain to the locomotion center causes problems with walking.
Although gait disturbance in individuals with spinal cord injury is attributed to the interruption of neural pathways from brain to the spinal locomotor center, neural circuits located above and below the lesion maintain most of their functions. An artificial connection that bridges the lost pathway and connects brain to spinal circuits has potential to ameliorate the functional loss.
http://www.ncbi.nlm.nih.gov/pubmed/25122909

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