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Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 9:07am

Sugar-coated gold nanoparticles can quickly eliminate bacterial infections, no antibiotics required

If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. Oral biofilms, also known as plaques, formed by bacteria such as Streptococcus mutans can cause significant tooth decay. Wound infections, which are commonly caused by Staphylococcus bacteria, can greatly delay the healing process. In either case, the densely packed network of proteins and carbohydrates within biofilms can prevent antibiotics from reaching microbes throughout the affected area.

But that isn't the extent of the issue posed by biofilms. Not only are they difficult to remove, but they are troublesome to discern in the first place.

These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slime, are difficult to dislodge. A new strategy may offer a simple way to break up the muck and destroy the bacteria.

This new research identified a solution to knock out both problems with one stone: gold.

Researchers have developed sugar-coated gold nanoparticles that they used to both image and destroy biofilms.

Gold is nontoxic and readily converts energy from light sources into heat, making it a prime candidate for photothermal therapy, a strategy that utilizes the heat from nanoparticles to kill nearby pathogens. In addition to generating heat, the nanoparticles emit detectable ultrasound waves in response to light, meaning that gold particles can be visualized using a technique called photoacoustic imaging.

In the new study, the authors encapsulated gold spheres within larger golden cage-shaped nanoparticles to optimize their response to light for both therapeutic and imaging purposes. To make the particles appealing to bacteria, they coated them in dextran, a carbohydrate that is a common building block of biofilms.

In a study published in the Journal of Clinical Investigation, the authors demonstrated the diagnostic and therapeutic potential of the nanoparticles on the teeth and wounded skin of rats and mice, eliminating the biofilms in as little as one minute and outperforming common antimicrobials. 

Part 1

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:21am

Study finds no persistent cough in four out of five individuals with tuberculosis in Africa and Asia

More than 80% of patients with tuberculosis, the world's most deadly infection, do not have a persistent cough, despite this being seen as a key symptom of the disease. The infection is predominantly transmitted by coughing, but probably also through simply breathing.

Researchers analyzed data on more than 600,000 individuals in Africa and Asia and found that 82.8% of those with tuberculosis had no persistent cough and 62.5% had no cough at all. These results are published today in The Lancet Infectious Diseases.

The  results indicate the probable reason why, despite huge efforts to diagnose and treat the disease, the tuberculosis (TB) burden across Africa and Asia is hardly declining.

A persistent cough is often the entry point for a diagnosis, but if 80% of those with TB don't have one, then it means that a diagnosis will happen later, possibly after the infection has already been transmitted to many others, or not at all.

 Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual participant data meta-analysis, The Lancet Infectious Diseases (2024). DOI: 10.1016/S1473-3099(24)00011-2

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:15am

Progesterone protects babies from preterm birth in women with a short cervix, research shows

Preterm birth, defined as birth prior to 37 weeks, remains a serious problem with far-reaching consequences. Approximately 13.5 million children worldwide are born preterm each year. Children who are born preterm are at higher risk for, both physical and developmental, lifelong complications. Preventing preterm birth is therefore a major priority.

At around 20 weeks of pregnancy women with a short cervix have an increased risk of preterm birth. Preventing preterm birth in pregnant women with a short cervix is a crucial step in protecting the health of the child. Research now shows that, in pregnant women with a short cervix around 20 weeks, progesterone is better than a cervical pessary at reducing the risk of severe preterm birth. This study was published in the BMJ.

This is an important improvement that can contribute to the reduction of preterm births and the associated complications, such as an increased risk of infant mortality and long-term health problems for the child.

Researchers investigated the best treatment for women with a cervical length shorter than 25 mm at the 20-week ultrasound scan. A total of 25 centers across the Netherlands participated in this study.

The results of this study show that progesterone is more effective than a pessary in reducing extreme preterm birth. This study underlines the importance of measuring the length of the cervix during the 20-week ultrasound scan and informing women with a cervix shorter than 25 mm about the possibility of treatment with progesterone. For women with a cervical length between 25 mm and 35 mm, there was no significant difference in the number of complications due to preterm birth between the group taking progesterone and the group using a pessary.

Cervical pessary versus vaginal progesterone in women with a singleton pregnancy, a short cervix, and no history of spontaneous preterm birth at less than 34 weeks' gestation: open label, multicentre, randomised, controlled trial, The BMJ (2024). DOI: 10.1136/bmj-2023-077033

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 7:04am

Study finds rerouting of airplanes to reduce contrails not as expensive as thought

A small team of environmental scientists has found via simulations that rerouting commercial airplanes to reduce contrails would be less expensive than previously thought. In their study, published in the journal Environmental Research: Infrastructure and Sustainability, the group used data from prior studies to create simulations of airplanes routed to prevent the development of contrails.

Prior research has shown that high-altitude airplanes are disproportionate contributors to climate change due to the multiple ways they impact the environment. In addition to the greenhouse gases they emit, jets that fly at high altitudes can also create contrails, white vapor trails of ice, water vapour and particulate matter.

When several planes fly in the same general area over the same period of time, the contrails can combine, leading to the formation of cirrus clouds, which can act like a blanket, holding in heat. Prior research has shown that this accounts for approximately 35% of the total aviation contribution to global warming.

Prior research has also shown that just 2%–10% of flights create approximately 80% of contrails. And because rerouting of jet planes can prevent the creation of contrails, researchers have suggested that the commercial aviation industry could greatly reduce its environmental footprint by doing so. But some argue that doing so would be too expensive to justify its cost.

To find out if that might be the case, American Airlines, working with another team of researchers last summer, used weather and satellite data to create software models and AI prediction tools to determine whether it was feasible to divert planes from airspace that would lead to contrail formation. They found that it appeared possible to reduce contrail formation by approximately 54%.

In this new effort, the research team used the same data to create simulations of 85,000 high-altitude flights and found that reducing contrails by 73% would raise fuel costs by just 0.11% and overall operating costs by just 0.08%. They also noted that rerouting aircraft under such a scenario would only involve 14% of all flights.

 Alejandra Martin Frias et al, Feasibility of contrail avoidance in a commercial flight planning system: an operational analysis, Environmental Research: Infrastructure and Sustainability (2024). DOI: 10.1088/2634-4505/ad310c

Comment by Dr. Krishna Kumari Challa on March 14, 2024 at 6:58am

Jets release heat, water vapour, and particulate matter that can produce thin clouds in the sky, known as “contrails”. When numerous flights pass through some areas, these contrails can form clouds that absorb radiation escaping from the surface, acting as blankets floating above the Earth.

Comment by Dr. Krishna Kumari Challa on March 13, 2024 at 11:31am

There exists a fundamental limit to what can be predicted with turbulence," according to researchers. "You see this with weather forecasts; there is always a fundamental source of randomness. The precise sense in which this unpredictability was inevitable wasn't fully understood before this work."

It's that randomness that makes it so hard to accurately predict the weather more than a few hours in advance. Meteorological stations sample weather in select locations, and computer simulations stitch them together, but without knowing the exact weather everywhere right now, it's hard to predict the exact weather everywhere in the future. This paper hints at the possibility that fundamental limits will always exist because randomness will always show up.

There may also be implications in astrophysics research. Scientists already understand that computer simulations of how galaxies are formed and how our universe evolved are sensitive to noise. Often, the behaviours of stars, planets, and galaxies cannot be easily explained and may be attributed to the kinds of microscopic noise that researchers have uncovered now.

Dmytro Bandak et al, Spontaneous Stochasticity Amplifies Even Thermal Noise to the Largest Scales of Turbulence in a Few Eddy Turnover Times, Physical Review Letters (2024). DOI: 10.1103/PhysRevLett.132.104002. On arXiv: DOI: 10.48550/arxiv.2401.13881

Part 2

Comment by Dr. Krishna Kumari Challa on March 13, 2024 at 11:28am

New research shows turbulent flows can be caused by minute triggers

We experience turbulence every day: a gust of wind, water gushing down a river, or mid-flight bumps on an airplane.

Although it may be easy to understand what causes some kinds of turbulence—a felled tree in a river or a bear splashing around for salmon—there is now evidence that a very small disturbance at the start can have dramatic effects later. Instead of a tree, think of a twig—or even the swerving motion of a molecule.

The butterfly effect

A butterfly flaps its wings in Brazil, which later causes a tornado in Texas. Although we may commonly use the phrase to denote the seeming interconnectedness of our own lives, the term "butterfly effect" is sometimes associated with chaos theory. Researchers said their work represents a more extreme version of the butterfly effect, first described by mathematician and meteorologist Edward Lorenz in 1969.

What researchers have learned is that in turbulent systems, a very small disturbance at one point will have an amplified effect at a finite point in the future, but through a mechanism that is faster than chaos.

Although the mathematical mechanism for this amplification, known as spontaneous stochasticity, was discovered about 25 years ago. The fact that the random motion of molecules, responsible for the everyday phenomenon of temperature, could generate spontaneous stochasticity was not known before this work.

Thinking back on the twig in the river, while you might notice a small disturbance where the water flows over the twig, you wouldn't expect it to create a great deal of turbulence (via eddies and swirls) downstream. Yet that is precisely what this new paper shows. The mechanism is known as spontaneous stochasticity, because the randomness arises even though the fluid motion was expected to be predictable.

Furthermore, it would be impossible to pinpoint the twig that had originally set the eddies and swirls in motion. In fact, there may be no disturbance in the water flow where the twig is located at all.

The research team's findings also showed that spontaneous stochasticity happens regardless of the initial disturbance. Whether it's a twig, a pebble, or a clod of dirt, the randomness you get on a large scale is the same. In other words, the randomness is intrinsic to the process.

Part 1

Comment by Dr. Krishna Kumari Challa on March 13, 2024 at 11:18am

A coral superhighway in the Indian Ocean

New research has revealed that, despite being scattered across more than a million square kilometers, remote coral reefs across the Seychelles are closely related. Using genetic analyses and oceanographic modeling, researchers have demonstrated for the first time that a network of ocean currents scatter significant numbers of larvae between these distant islands, acting as a "coral superhighway."

This discovery is very important because a key factor in coral reef recovery is larval supply. Although corals have declined alarmingly across the world due to climate change and a number of other factors, actions can be taken at local and national scale to improve reef health and resilience.

These actions can be more effective when we better understand the connectivity between coral reefs, by—for instance—prioritizing conservation efforts around coral reefs that act as major larval sources to support regional reef resilience.

The researchers collaborated with a wide range of coral reef management organizations and the Seychelles government to collect coral samples from 19 different reef sites. A comprehensive genetic analysis revealed recent gene flow between all sample sites—possibly within just a few generations—suggesting that coral larvae may be frequently transferred between different populations. The results also hinted at the existence of a new cryptic species of the common bouldering coral, Porites lutea.

The genetic analyses were then coupled with oceanographic modeling, simulating the process of larval dispersal. These simulations allowed researchers to visualize the pathways coral larvae take to travel between reefs across the wider region, and determine the relative importance of physical larval dispersal versus other biological processes in setting coral connectivity.

This revealed that dispersal of coral larvae directly between reefs across the Seychelles is highly plausible. For example, coral larvae spawned at the remote Aldabra atoll could disperse westwards towards the east coast of Africa via the East African Coastal Current. From here, they would then travel north along the coast, with some potentially even reaching the South Equatorial Counter Current, which could bring them eastwards again back towards the Inner Islands of Seychelles.

While these long-distance dispersal events are possible, it is likely that much of the connectivity between remote islands across the Seychelles may be established through "stepping-stone" dispersal. This suggests that centrally located coral reefs in Seychelles, and possibly East Africa, may play an important role in linking the most remote islands.

Integration of population genetics with oceanographic models reveals strong connectivity among coral reefs across Seychelles, Scientific Reports (2024). DOI: 10.1038/s41598-024-55459-x

Comment by Dr. Krishna Kumari Challa on March 13, 2024 at 10:50am

Rainforest's next generation of trees threatened 30 years after logging

Rainforest seedlings are more likely to survive in natural forests than in places where logging has happened—even if tree restoration projects have taken place, new research shows. The work appears in Global Change Biology.

Scientists monitored over 5,000 seedlings for a year and a half in North Borneo.

They studied a landscape containing both natural forest and areas logged 30 years ago—some of which were recovering naturally, while some had been restored by methods including tree planting.

A drought had triggered "mast fruiting" across the region, with trees simultaneously dropping fruit en masse and new seedlings emerging.

At first, both natural forest and restored forest had similarly high numbers of seedlings, compared to naturally recovering forest—suggesting restoration activities enhanced fruit production.

But these benefits did not last: low seedling survival in the restored forest meant that by the end of the study, similarly low numbers of seedlings remained in restored and naturally recovering forest. Seedling populations remained higher in natural forest.

Together, these results show that regeneration may be challenged by different factors depending on the restoration approach—seed availability in naturally recovering sites and seedling survival in sites where planted trees have matured. These differences may have longer-term implications for how forests can deliver key ecosystem services such as carbon sequestration.

Bornean tropical forests recovering from logging at risk of regeneration failure Running Title: Seedling responses to logging and restoration., Global Change Biology (2024).

Comment by Dr. Krishna Kumari Challa on March 13, 2024 at 10:00am

How invisible presences hijack the social counting brain in Parkinson's disease

If you had to estimate the number of people in a room, without counting them one by one, by nature you would overcount them. That's because—simply put from a Darwinian perspective of how we have evolved—it's better to overcount potentially harmful agents and predators than to underestimate them. This overcounting social behavior is shown to be true in humans as well as animals. It's certainly better to detect too many tigers (even if absent) during a jungle excursion than to miss a hungry one.

Now,  neuroscientists show that if you experience hallucinations, especially when related to an illness like Parkinson's disease, then you will overestimate the number of people in a room to a greater degree. They also show that if you have hallucinations but are asked to estimate the number of boxes in a room, which are inanimate control objects, then no extra overestimation occurs, shedding light on the social nature of this overcounting.

The results are published in Nature Communications.

The fact that patients of Parkinson's disease have a much higher over-estimation in counting people is mind-blowing because Parkinson's disease is classically viewed as a movement disorder.

This new work shows that Parkinson's may also be a perceptual disorder, especially of social stimuli, and that invisible presences in Parkinson's disease may impair even more the counting social brain.

The category of hallucinations investigated by the neuroscientists is called presence hallucinations, for which people report an invisible presence next to them, even though no one is there. Such hallucinations are considered to be minor compared to visual hallucinations, for instance. They may be experienced early on in patients with Parkinson's disease, sometimes even before diagnosis. Presence hallucinations are also a known early marker of cognitive decline in Parkinson's disease.

The results of the study support the idea that the invisible presence (and related brain mechanisms) are responsible for this overcounting of people. When presence hallucinations are experienced—either due to disease or induced artificially—this extra presence gets subconsciously translated into an over-estimation of the number of people we think we see. In essence, the invisible presence gets added in the counting process, but only in counting people.

Nature Communications (2024).

https://www.nature.com/articles/s41467-024-45912-w

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