Science, Art, Litt, Science based Art & Science Communication
JAI VIGNAN
All about Science - to remove misconceptions and encourage scientific temper
Communicating science to the common people
'To make them see the world differently through the beautiful lense of science'
Members: 22
Latest Activity: 3 hours ago
WE LOVE SCIENCE HERE BECAUSE IT IS A MANY SPLENDOURED THING
THIS IS A WAR ZONE WHERE SCIENCE FIGHTS WITH NONSENSE AND WINS
“The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge.”
"Being a scientist is a state of mind, not a profession!"
"Science, when it's done right, can yield amazing things".
The Reach of Scientific Research From Labs to Laymen
The aim of science is not only to open a door to infinite knowledge and wisdom but to set a limit to infinite error.
"Knowledge is a Superpower but the irony is you cannot get enough of it with ever increasing data base unless you try to keep up with it constantly and in the right way!" The best education comes from learning from people who know what they are exactly talking about.
Science is this glorious adventure into the unknown, the opportunity to discover things that nobody knew before. And that’s just an experience that’s not to be missed. But it’s also a motivated effort to try to help humankind. And maybe that’s just by increasing human knowledge—because that’s a way to make us a nobler species.
If you are scientifically literate the world looks very different to you.
We do science and science communication not because they are easy but because they are difficult!
“Science is not a subject you studied in school. It’s life. We 're brought into existence by it!"
Links to some important articles :
1. Interactive science series...
a. how-to-do-research-and-write-research-papers-part 13
b. Some Qs people asked me on science and my replies to them...
Part 6, part-10, part-11, part-12, part 14 , part- 8,
part- 1, part-2, part-4, part-5, part-16, part-17, part-18 , part-19 , part-20
part-21 , part-22, part-23, part-24, part-25, part-26, part-27 , part-28
part-29, part-30, part-31, part-32, part-33, part-34, part-35, part-36, part-37,
part-38, part-40, part-41, part-42, part-43, part-44, part-45, part-46, part-47
Part 48, part49, Critical thinking -part 50 , part -51, part-52, part-53
part-54, part-55, part-57, part-58, part-59, part-60, part-61, part-62, part-63
part 64, part-65, part-66, part-67, part-68, part 69, part-70 part-71, part-73 ...
.......306
BP variations during pregnancy part-72
who is responsible for the gender of their children - a man or a woman -part-56
c. some-questions-people-asked-me-on-science-based-on-my-art-and-poems -part-7
d. science-s-rules-are-unyielding-they-will-not-be-bent-for-anybody-part-3-
e. debate-between-scientists-and-people-who-practice-and-propagate-pseudo-science - part -9
f. why astrology is pseudo-science part 15
g. How Science is demolishing patriarchal ideas - part-39
2. in-defence-of-mangalyaan-why-even-developing-countries-like-india need space research programmes
3. Science communication series:
a. science-communication - part 1
b. how-scienitsts-should-communicate-with-laymen - part 2
c. main-challenges-of-science-communication-and-how-to-overcome-them - part 3
d. the-importance-of-science-communication-through-art- part 4
e. why-science-communication-is-geting worse - part 5
f. why-science-journalism-is-not-taken-seriously-in-this-part-of-the-world - part 6
g. blogs-the-best-bet-to-communicate-science-by-scientists- part 7
h. why-it-is-difficult-for-scientists-to-debate-controversial-issues - part 8
i. science-writers-and-communicators-where-are-you - part 9
j. shooting-the-messengers-for-a-different-reason-for-conveying-the- part 10
k. why-is-science-journalism-different-from-other-forms-of-journalism - part 11
l. golden-rules-of-science-communication- Part 12
m. science-writers-should-develop-a-broader-view-to-put-things-in-th - part 13
n. an-informed-patient-is-the-most-cooperative-one -part 14
o. the-risks-scientists-will-have-to-face-while-communicating-science - part 15
p. the-most-difficult-part-of-science-communication - part 16
q. clarity-on-who-you-are-writing-for-is-important-before-sitting-to write a science story - part 17
r. science-communicators-get-thick-skinned-to-communicate-science-without-any-bias - part 18
s. is-post-truth-another-name-for-science-communication-failure?
t. why-is-it-difficult-for-scientists-to-have-high-eqs
u. art-and-literature-as-effective-aids-in-science-communication-and teaching
v.* some-qs-people-asked-me-on-science communication-and-my-replies-to-them
** qs-people-asked-me-on-science-and-my-replies-to-them-part-173
w. why-motivated-perception-influences-your-understanding-of-science
x. science-communication-in-uncertain-times
y. sci-com: why-keep-a-dog-and-bark-yourself
z. How to deal with sci com dilemmas?
A+. sci-com-what-makes-a-story-news-worthy-in-science
B+. is-a-perfect-language-important-in-writing-science-stories
C+. sci-com-how-much-entertainment-is-too-much-while-communicating-sc
D+. sci-com-why-can-t-everybody-understand-science-in-the-same-way
E+. how-to-successfully-negotiate-the-science-communication-maze
4. Health related topics:
a. why-antibiotic-resistance-is-increasing-and-how-scientists-are-tr
b. what-might-happen-when-you-take-lots-of-medicines
c. know-your-cesarean-facts-ladies
d. right-facts-about-menstruation
e. answer-to-the-question-why-on-big-c
f. how-scientists-are-identifying-new-preventive-measures-and-cures-
g. what-if-little-creatures-high-jack-your-brain-and-try-to-control-
h. who-knows-better?
k. can-rust-from-old-drinking-water-pipes-cause-health-problems
l. pvc-and-cpvc-pipes-should-not-be-used-for-drinking-water-supply
m. melioidosis
o. desensitization-and-transplant-success-story
p. do-you-think-the-medicines-you-are-taking-are-perfectly-alright-then revisit your position!
q. swine-flu-the-difficlulties-we-still-face-while-tackling-the-outb
r. dump-this-useless-information-into-a-garbage-bin-if-you-really-care about evidence based medicine
s. don-t-ignore-these-head-injuries
u. allergic- agony-caused-by-caterpillars-and-moths
General science:
a.why-do-water-bodies-suddenly-change-colour
b. don-t-knock-down-your-own-life-line
c. the-most-menacing-animal-in-the-world
d. how-exo-planets-are-detected
e. the-importance-of-earth-s-magnetic-field
f. saving-tigers-from-extinction-is-still-a-travail
g. the-importance-of-snakes-in-our-eco-systems
h. understanding-reverse-osmosis
i. the-importance-of-microbiomes
j. crispr-cas9-gene-editing-technique-a-boon-to-fixing-defective-gen
k. biomimicry-a-solution-to-some-of-our-problems
5. the-dilemmas-scientists-face
6. why-we-get-contradictory-reports-in-science
7. be-alert-pseudo-science-and-anti-science-are-on-prowl
8. science-will-answer-your-questions-and-solve-your-problems
9. how-science-debunks-baseless-beliefs
10. climate-science-and-its-relevance
11. the-road-to-a-healthy-life
12. relative-truth-about-gm-crops-and-foods
13. intuition-based-work-is-bad-science
14. how-science-explains-near-death-experiences
15. just-studies-are-different-from-thorough-scientific-research
16. lab-scientists-versus-internet-scientists
17. can-you-challenge-science?
18. the-myth-of-ritual-working
19.science-and-superstitions-how-rational-thinking-can-make-you-work-better
20. comets-are-not-harmful-or-bad-omens-so-enjoy-the-clestial-shows
21. explanation-of-mysterious-lights-during-earthquakes
22. science-can-tell-what-constitutes-the-beauty-of-a-rose
23. what-lessons-can-science-learn-from-tragedies-like-these
24. the-specific-traits-of-a-scientific-mind
25. science-and-the-paranormal
26. are-these-inventions-and-discoveries-really-accidental-and-intuitive like the journalists say?
27. how-the-brain-of-a-polymath-copes-with-all-the-things-it-does
28. how-to-make-scientific-research-in-india-a-success-story
29. getting-rid-of-plastic-the-natural-way
30. why-some-interesting-things-happen-in-nature
31. real-life-stories-that-proves-how-science-helps-you
32. Science and trust series:
a. how-to-trust-science-stories-a-guide-for-common-man
b. trust-in-science-what-makes-people-waver
c. standing-up-for-science-showing-reasons-why-science-should-be-trusted
You will find the entire list of discussions here: http://kkartlab.in/group/some-science/forum
( Please go through the comments section below to find scientific research reports posted on a daily basis and watch videos based on science)
Get interactive...
Please contact us if you want us to add any information or scientific explanation on any topic that interests you. We will try our level best to give you the right information.
Our mail ID: kkartlabin@gmail.com
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa 5 hours ago. 1 Reply 0 Likes
Perceiving something—anything—in your surroundings is to become aware of what your senses are detecting. Now, neuroscientists have identified, for the first time, brain-cell circuitry in fruit flies…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Thursday. 1 Reply 0 Likes
Q: Is there any company trying to make antidote to get rid of corona vaccine side effects?Krishna: Till date, no.However, let me explain to you why we can manage vaccine side effects in majority of…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Thursday. 1 Reply 0 Likes
Q: Is it scientific to try and alter the result of an experiment to better meet your belief of what the result should be?Krishna: NO!Genuine Scientists never do such things. Because they think that…Continue
Started by Dr. Krishna Kumari Challa. Last reply by Dr. Krishna Kumari Challa on Thursday. 1 Reply 0 Likes
Bats, as the main predator of night-flying insects, create a selective pressure that has led many of their prey to evolve an early warning system of sorts: ears uniquely tuned to high-frequency bat…Continue
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As the world continues to struggle with the rapid spread of the omicron variant of the coronavirus and the still-lingering delta variant, scientists in France say they have discovered a new variant that contains multiple mutations.
Experts at the IHU Mediterranee Infection in Marseille said they had discovered the new variant in December in 12 patients living near Marseille, with the first patient testing positive after traveling to the central African nation of Cameroon.
The French scientists said they had identified 46 mutations in the new variant, dubbed B.1.640.2, that could make it more resistant to vaccines and more infectious than the original virus.
The results were posted on the online health sciences outlet MedRxiv, which publishes studies that have not been peer-reviewed or published in an academic journal. B.1.640.2 has neither been detected in other countries nor been labeled a "variant of concern" by the World Health Organization.
https://www.voanews.com/a/french-scientists-discover-new-coronaviru...
Designing war planes
Plastic packaging in grocery stores protects fruits and vegetables from spoilage, but also creates significant amounts of waste. Researchers have now developed a protective cover for fruit and vegetables based on renewable raw materials. For this project, they used cellulose. They spent more than a year developing a special protective cellulose coating that can be applied to fruits and vegetables. The result: Coated fruits and vegetables stay fresh significantly longer. In tests, the shelf life of, for instance, bananas was extended by more than a week. This significantly reduces food waste.
https://www.youtube.com/watch?v=JT77fj1eF3E&t=62s
https://www.youtube.com/watch?v=9-5YZ2cNSEo
Luana Amoroso et al, Sustainable Cellulose Nanofiber Films from Carrot Pomace as Sprayable Coatings for Food Packaging Applications, ACS Sustainable Chemistry & Engineering (2021). DOI: 10.1021/acssuschemeng.1c06345
https://phys.org/news/2022-01-ecological-coating-bananas.html?utm_s...
When we eat, energy-rich fats and glucose enter the bloodstream. Insulin normally shuttles these nutrients to cells in muscles and fat tissue, where they are either used immediately or stored for later use. In people with insulin resistance, glucose is not efficiently removed from the blood, and higher lipolysis increases the fatty acid levels. These extra fatty acids accelerate glucose production from the liver, compounding the already high glucose levels. Moreover, fatty acids accumulate in organs, exacerbating the insulin resistance—characteristics of diabetes and obesity.
Previously, the lab showed that injecting FGF1 dramatically lowered blood glucose in mice and that chronic FGF1 treatment relieved insulin resistance. But how it worked remained a mystery.
In the current work, the team investigated the mechanisms behind these phenomena and how they were linked. First, they showed that FGF1 suppresses lipolysis, as insulin does. Then they showed that FGF1 regulates the production of glucose in the liver, as insulin does. These similarities led the group to wonder if FGF1 and insulin use the same signaling (communication) pathways to regulate blood glucose.
It was already known that insulin suppresses lipolysis through PDE3B, an enzyme that initiates a signaling pathway, so the team tested a full array of similar enzymes, with PDE3B at the top of their list. They were surprised to find that FGF1 uses a different pathway—PDE4.
"This mechanism is basically a second loop, with all the advantages of a parallel pathway. In insulin resistance, insulin signaling is impaired. However, with a different signaling cascade, if one is not working, the other can. That way you still have the control of lipolysis and blood glucose regulation.
Finding the PDE4 pathway opens new opportunities for drug discovery and basic research focused on high blood glucose (hyperglycemia) and insulin resistance. The scientists are eager to investigate the possibility of modifying FGF1 to improve PDE4 activity. Another route is targeting multiple points in the signaling pathway before PDE4 is activated.
The unique ability of FGF1 to induce sustained glucose lowering in insulin-resistant diabetic mice is a promising therapeutic route for diabetic patients.
Ronald M Evans, FGF1 and insulin control lipolysis by convergent pathways, Cell Metabolism (2022). DOI: 10.1016/j.cmet.2021.12.004. www.cell.com/cell-metabolism/f … 1550-4131(21)00623-9
https://medicalxpress.com/news/2022-01-route-blood-sugar-independen...
The discovery of insulin 100 years ago opened a door that would lead to life and hope for millions of people with diabetes. Ever since then, insulin, produced in the pancreas, has been considered the primary means of treating conditions characterized by high blood sugar (glucose), such as diabetes. Now, scientists have discovered a second molecule, produced in fat tissue, that, like insulin, also potently and rapidly regulates blood glucose. Their finding could lead to the development of new therapies for treating diabetes, and also lays the foundation for promising new avenues in metabolism research.
The study, which was published in Cell Metabolism on January 4, 2022, shows that a hormone called FGF1 regulates blood glucose by inhibiting fat breakdown (lipolysis). Like insulin, FGF1 controls blood glucose by inhibiting lipolysis, but the two hormones do so in different ways. Importantly, this difference could enable FGF1 to be used to safely and successfully lower blood glucose in people who suffer from insulin resistance.
Finding a second hormone that suppresses lipolysis and lowers glucose is a scientific breakthrough. Scientists have identified a new player in regulating fat lipolysis that will help us understand how energy stores are managed in the body.
Part 1
Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood.
Wenlu Fan et al, FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism, Nucleic Acids Research (2021). DOI: 10.1093/nar/gkab1187
https://phys.org/news/2022-01-scientists-reveal-genetic-basis-mitoc...
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The microbes that live inside our mouths, collectively known as the oral microbiome, impact our overall health in many ways that are not yet fully understood. Some bacteria cause inflammation, leading to periodontitis and other systemic diseases, such as cardiovascular disease and diabetes. Other oral organisms have been associated with certain types of cancer. Scientists are working to understand how these microbes interact with one another and our bodies to tease out their individual roles in health and disease.
Among the diverse bacterial species living within our mouths is a group belonging to the Candidate Phyla Radiation (CPR). These bugs are especially mysterious because they are ultra-small, adopt a unique symbiotic lifestyle with their host bacteria, and most have yet to be cultured by scientists and studied in the lab. The only bacteria within the CPR to be examined in-depth are a group called TM7, which were cultivated for the first time in 2014.
Now scientists have developed a new model system using the first isolated human oral TM7 strain, TM7x, and its host bacterium, Actinomyces odontolyticus. Researchers used the model system to experimentally study these tiny bacteria, testing a hypothesis for how TM7 adapted to live inside humans, and providing empirical data to confirm previous genomic studies. Their findings were published today in the journal Proceedings of the National Academy of Sciences (PNAS).
Scientists have found TM7 in many different environments, including soil, groundwater, and the bodies of other mammals. Studies have shown that while maintaining a remarkably similar genome overall, the TM7 found in human mouths are unique from those in other environments because they have acquired a gene cluster encoding the arginine deiminase system, or ADS.
Researchers hypothesized that TM7 acquired ADS as an evolutionary advantage to help them adapt and survive in the human oral cavity. They tested this and found found that ADS helped TM7x break down arginine, a process that produces the compounds Adenosine triphosphate (ATP) and ammonia. The increased abundance of ATP and ammonia benefitted TM7x by increasing its infectivity, or ability to multiply. It also protected TM7x and its host bacterium from acid stress, a condition that microbes frequently encounter in the human oral cavity due to the acid created when bacteria feed on and metabolize dietary carbohydrates. Ultimately, the experiments showed TM7x were able to survive in the experimental environment for longer than they could without the addition of arginine, thanks to ADS.
Earlier study: Otari Chipashvili et al, Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation, Cell Host & Microbe (2021). DOI: 10.1016/j.chom.2021.09.009
Acquisition of the arginine deiminase system benefits epiparasitic Saccharibacteria and their host bacteria in a mammalian niche environment, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2114909119.
https://phys.org/news/2022-01-gain-insights-ultrasmall-bacteria-env...
One of the reasons why a clearer understanding of the channel protein's natural structure is important is to advance the development of treatments for genetic disorders for which there is no known cure, such as retinitis pigmentosa. With this disease, photoreceptors gradually die off, leaving people blind. One possible cause is that the body is unable to correctly produce the CNG channel protein due to a genetic defect. As a result, the ion channel does not close completely when light hits the eye, disrupting the cell's electrochemical balance and causing the cells to die.
If we could find molecules that affect the protein in such a way that the channel would completely close, we could prevent the cells from dying—and thus stop people going blind.
Now that researchers have identified the precise structure of the protein they are able to search specifically for such molecules.
The protein comprises four parts: three lots of subunit A, and one lot of subunit B. A correctly functioning ion channel is only possible in this combination. In their study, PSI scientists show why the B subunit seems to play such an important role: a side arm of the protein—a single amino acid—protrudes from the rest of the protein, like a barrier across a gateway. This narrows the passage in the channel to the point where no ions can pass through.
It is interesting to note that the additional barrier is found not only in the protein from the cow's eye, but seems to apply to all types of animal, as the scientists showed. Whether crocodiles, eagles or humans—all living creatures with an ion channel in their eye have the same protruding amino acid at this position in the protein. As it has been preserved so consistently during evolution, it must be essential for the functioning of the channel.
Diane C. A. Barret et al, The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods, Nature Structural & Molecular Biology (2021). DOI: 10.1038/s41594-021-00700-8
https://phys.org/news/2022-01-newly-discovered-protein-rod-cells-re...
**
scientists have shed light on an important component of the eye: a protein in the rod cells of the retina which helps us see in dim light. Acting as an ion channel in the cell membrane, the protein is responsible for relaying the optical signal from the eye to the brain. If a genetic disorder disrupts the molecular function in a person, they will go blind. Scientists have deciphered the protein's three-dimensional structure, preparing the way for innovative medical treatments. The study is published in the scientific journal Nature Structural & Molecular Biology.
It's thanks to the rod cells in our eye that we can observe the stars in the night sky.
These photo cells are so sensitive to light that they can detect even a single photon reaching us from a very remote part of the universe—a truly incredible feat." The ability of our brain to eventually translate these light beams into a visual impression is partly down to the cyclic nucleotide-gated (CNG) ion channels whose three-dimensional structure has now been illuminated by a research group.
The ion channel acts as a gatekeeper controlling whether specific particles are allowed through to the interior of the receptor cell. It is embedded in the protein-rich shell—the cell membrane—of the rod cells. In darkness, the ion channel, and thus the gate to the cell, is completely open. But when light hits the eye, it triggers a cascade of processes in the rod cells. This ultimately causes the gate to close, with the result that positively charged particles, such as calcium ions, can no longer enter into the cell.
This electrochemical signal continues via the nerve cells into the brain's visual cortex, where a visual impression—such as a flash of light—is created. The scientists used cryo-electron microscopy to reveal the three-dimensional structure of the ion channel.
Part 1
The Baseline #10 - How To Kick A Pulsar Out Of The Galaxy from NRAO Outreach on Vimeo.
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